For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTIDATADNTKEARRQRLGDRIRRLFTDDEQFRAAKPDTAVDTAVAQPGLRLAQVVATIMNGYADRPALG HRVQELVADAAGRSTLRPLPEFETVTYGELWGMARALASTWYHDPAAPVRAGDFVAMLGFTSVDYTAVDL ACIHLGAVAVPLQTSASASNWTAILAESEPAVLAVSAELLDTAMESVLATPSLRHITVFDYHPGVDVQRE SLESAQHRIAEAGLPISVDPIPLAIGHGRALPDAPLFTAEEGTDPLALVIYTSGSTGTPKGATYSEKMVA KPWLRADTLSSKAEIPLINLNFMPMSHVMGRGSLVTALACGGLAYFAASSDMSTLFEDITLTRPTVVTLV PRVCDMLFQRYRNEVERRTGLDPAADLATLDADVKTDIRENLFGGRVLTIVCGSAPLSEELAAFIESCLD ARITDGYGSTEAGVIVRNGRIQRPPVIDYKLVDVPELGYFSTDKPHPRGELLVKAESVFGGYFKRPDVTA DVFDPDGYYKTGDIVAELEPDKIQIVDRRNNVIKLSQGEFVAIANLEAEFANSPLVHQICVYGSSERSYL LAVVVPTAEAYEQSGGDEDLLKRLIADSLAQVAREAQLQSYEVPRDFLLETEPFTAANGLLTGIAKLARP KLHEKYGARLEQLYSDIAAAQALELQALHSAGHEDKPVLDTVQRAVTALLGLSAAEVSPDAHFIDLGGDS LSALAFSDLLRDIFTVEVPVGDIVSAANDLTAIARIVERHREADGHSVTPTAESVHGAGHREIRAADLTL DKFIDADTLRAAPALSTFTGTPHTVLLTGANGYLGRFLALEWLERLDKTDGKLIAIVRGKNAEAAYRRLE EAFDTGDTQLLAHFRSLADKHLEVLAGDIGDPNLGLDADTWQRLAETVDVIVHPAALVNHVLPYSQLFGP NVVGTAEIIKLALTTKIKPITYLSTVAVAISVDPKVFDEDSDIRTISAVRPINDGYANGYGNAKWAGEVL LREAHDLCGLPVAVFRSDMILAHSRYTGQLNVPDQFTRLILSLIATGVAPGSFYQAHATGERPLAHYDGL PADFTASAITALGPIEEFHTYDSVNPHADGISLDNFVDWLIEAGYPIARIDNYTEWFTRFDTAIRSLPEK QKQHSLLPLLHAYRHPQHPHNGAFLPAIRFSEGVQAHLNADIPHLTRELIAKYAADLKQLGLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2963 | - | - | 100% (1183) | fatty-acid-CoA ligase FadD |
| M. abscessus ATCC 19977 | MAB_2962 | - | 0.0 | 70.12% (1188) | fatty-acid-CoA ligase FadD |
| M. abscessus ATCC 19977 | MAB_4714c | - | 0.0 | 55.12% (1192) | fatty-acid-coa ligase FadD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2621 | fadD9 | 0.0 | 54.96% (1179) | fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_2962 | - | 2e-34 | 26.75% (572) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2590 | fadD9 | 0.0 | 55.05% (1179) | fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_00484 | fadD9 | 0.0 | 54.39% (1184) | putative acyl-CoA synthetase |
| M. marinum M | MMAR_2117 | fadD9 | 0.0 | 56.26% (1182) | fatty-acid-CoA ligase FadD9 |
| M. avium 104 | MAV_3471 | - | 0.0 | 56.23% (1179) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2956 | - | 0.0 | 56.93% (1184) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_1879 | fadD9 | 1e-143 | 50.09% (565) | PROBABLE FATTY-ACID-CoA LIGASE FADD9 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_1722 | - | 0.0 | 55.92% (1182) | fatty-acid-CoA ligase FadD9 |
| M. vanbaalenii PYR-1 | Mvan_2578 | - | 0.0 | 56.25% (1184) | thioester reductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2956|M.smegmatis_MC2_155 --------------MTIETREDR---FNRRIDHLFETDPQFAAARPDEAI
Mvan_2578|M.vanbaalenii_PYR-1 --------------MSTDTREDR---LARRIADLYATDPQFAAAAPDDAI
Mb2621|M.bovis_AF2122/97 --------------MS--INDQR---LTRRVEDLYASDAQFAAASPNEAI
Rv2590|M.tuberculosis_H37Rv --------------MS--INDQR---LTRRVEDLYASDAQFAAASPNEAI
MMAR_2117|M.marinum_M --------------MSPITREER---LERRIQDLYANDPQFAAAKPATAI
MUL_1722|M.ulcerans_Agy99 --------------MSPITREER---LERRIQDLYANDPQFAAAKPVTAI
MLBr_00484|M.leprae_Br4923 MWRQQSISHRKESVMSTITKQEKQ--LARRVDDLTANDPQFAAAKPDPAV
MAV_3471|M.avium_104 --------------MSTATHDER---LDRRVHELIATDPQFAAAQPDPAI
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 ---------MTIDATADNTKEARRQRLGDRIRRLFTDDEQFRAAKPDTAV
Mflv_2962|M.gilvum_PYR-GCK -----------------------------MTAREFTVPAPFTVEERDNIV
MSMEG_2956|M.smegmatis_MC2_155 SAAAADPELRLPAAVKQILAGYADRPALGKRAVEFVTD-EEGRTTAKLLP
Mvan_2578|M.vanbaalenii_PYR-1 SHAIDQPGTHLPVIVQTVLDGYAERPALGQRAVRFVTDPATGRTTTELLP
Mb2621|M.bovis_AF2122/97 TQAIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLP
Rv2590|M.tuberculosis_H37Rv TQAIDQPGVALPQLIRMVMEGYADRPALGQRALRFVTDPDSGRTMVELLP
MMAR_2117|M.marinum_M TAAIERPGLPLPQIIETVMTGYADRPALAQRSVEFVTDAGTGHTTLRLLP
MUL_1722|M.ulcerans_Agy99 TAAIERPGLPLPQIIETVMTGYADRPALAQRSVEFVTDAGTGHTTLRLLP
MLBr_00484|M.leprae_Br4923 AAALAQPGLRLPQIIQTALDGYAERPALGQRVAEFTKDPKTGRTSMELLP
MAV_3471|M.avium_104 TAALEQPGLRLPQIIRTVLDGYADRPALGQRVVEFVTDAKTGRTSAQLLP
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 DTAVAQPGLRLAQVVATIMNGYADRPALGHRVQELVAD-AAGRSTLRPLP
Mflv_2962|M.gilvum_PYR-GCK GAVFTHERDDPDHVIFQRLVDG----------------------------
MSMEG_2956|M.smegmatis_MC2_155 RFDTITYRQLAGRIQAVTNAWHNH---PVNAGDRVAILGFTSVDYTTIDI
Mvan_2578|M.vanbaalenii_PYR-1 RFETITYAELSRRIHAVTAALT-----DVHPGDRVAVLGFTSIDYTTVDM
Mb2621|M.bovis_AF2122/97 RFETITYRELWARAGTLATALSAE--PAIRPGDRVCVLGFNSVDYTTIDI
Rv2590|M.tuberculosis_H37Rv RFETITYRELWARAGTLATALSAE--PAIRPGDRVCVLGFNSVDYTTIDI
MMAR_2117|M.marinum_M HFETISYGELWDRISALADVLSTE--QTVKPGDRVCLLGFNSVDYATIDM
MUL_1722|M.ulcerans_Agy99 HFETISYGELWDRISALADVLSTE--QTVKPSDRVCLLGFNSVDYATIDM
MLBr_00484|M.leprae_Br4923 SFETITYRQLGDRVGALARAWRHD---LLHAGYRVCVLGFNSVDYAIIDM
MAV_3471|M.avium_104 RFETITYGEVAQRVSALGRALSDD---AVHPGDRVCVLGFNSVDYATIDM
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 EFETVTYGELWGMARALASTWYHDPAAPVRAGDFVAMLGFTSVDYTAVDL
Mflv_2962|M.gilvum_PYR-GCK KWIDVTARQAAGQIRSAARGLIAEG---VQAGDRVALLSATRYEWPILDF
MSMEG_2956|M.smegmatis_MC2_155 ALLELGAVSVPLQTSAPVAQLQPIVAETEPKVIASSVDFLADAVALVESG
Mvan_2578|M.vanbaalenii_PYR-1 ALAMLGAVAVPLQTSAPATTVRPIVAETEPVVIASSVDALTDAVGLALDA
Mb2621|M.bovis_AF2122/97 ALIRLGAVSVPLQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEV-LAG
Rv2590|M.tuberculosis_H37Rv ALIRLGAVSVPLQTSAPVTGLRPIVTETEPTMIATSIDNLGDAVEV-LAG
MMAR_2117|M.marinum_M TLARLGAVAVPLQTSAAITQLQPIVAETQPTMIAASVDALADATELALSG
MUL_1722|M.ulcerans_Agy99 TLARLGAVAVPLQTSAAITQLQPIVAETQPTMIAASVDALADATELALSG
MLBr_00484|M.leprae_Br4923 ALGVIGAVAVPLQTSAAITQLQSIVTETEPSMIATSVNQLPDTVELIL-S
MAV_3471|M.avium_104 ALGAIGAVSVPLQTSAAISSLQPIVAETEPTLIASSVNQLSDAVQLITGA
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 ACIHLGAVAVPLQTSASASNWTAILAESEPAVLAVSAELLDTAMESVLAT
Mflv_2962|M.gilvum_PYR-GCK AILSIGAVTVPIYETSSAEQVQFVLADSGAVAAIAETDAHAAHIEAQRDT
MSMEG_2956|M.smegmatis_MC2_155 PAP-SRLVVFD-YSHEVDDQREAFEAAKGKLAGTG--VVVETITDALDRG
Mvan_2578|M.vanbaalenii_PYR-1 PTV-TRLVVFD-HRAGVDDHRDALISASDRLRAANSPIEVETITDIVARG
Mb2621|M.bovis_AF2122/97 HAP-ARLVVFD-YHGKVDTHREAVEAARARLAGS---VTIDTLAELIER-
Rv2590|M.tuberculosis_H37Rv HAP-ARLVVFD-YHGKVDTHREAVEAARARLAGS---VTIDTLAELIER-
MMAR_2117|M.marinum_M QTA-TRVLVFD-HHRQVDAHRAAVESARERLAGS---AVVETLAEAIARG
MUL_1722|M.ulcerans_Agy99 QTA-TRVLVFD-HHRQVDAHRAAVESARERLAGS---AVVETLAEAIARG
MLBr_00484|M.leprae_Br4923 GQAPAKLVVFD-YHPEVDEQHDAVATARARLADSS--VVVESLTEVLGRG
MAV_3471|M.avium_104 EQAPTRLVVFD-YHPQVDDQREAVQDAAARLSGTG--VAVQTLAELLERG
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 PSL-RHITVFD-YHPGVDVQRESLESAQHRIAEAGLPISVDPIPLAIGHG
Mflv_2962|M.gilvum_PYR-GCK LPALRRIYVIDGSVPALDELAEAGASVDAAAVDER---------------
MSMEG_2956|M.smegmatis_MC2_155 ----RSLADAPLYVPDEADPLTLLIYTSGSTGTPKGAMYPESKTATMWQA
Mvan_2578|M.vanbaalenii_PYR-1 ----SKLPVRAQFS-ADGDALSLLIYTSGSTGAPKGAMYPQHLVANSWRR
Mb2621|M.bovis_AF2122/97 ----GRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRK
Rv2590|M.tuberculosis_H37Rv ----GRALPATPIADSADDALALLIYTSGSTGAPKGAMYRESQVMSFWRK
MMAR_2117|M.marinum_M DVPRGASAGSAPGTDVSDDSLALLIYTSGSTGAPKGAMYPRRNVATFWRK
MUL_1722|M.ulcerans_Agy99 DVPRGASAGSAPGTDVSDDSLALLIYTSGSTGAPKGAMYPRRNVATFWRK
MLBr_00484|M.leprae_Br4923 ---KTLPATPIPVADDSADPLALLIYTSGSTGAPKGAMYLQSNVGKMWRR
MAV_3471|M.avium_104 ---KDLPAVAEPPADE--DSLALLIYTSGSTGAPKGAMYPQSNVGKMWRR
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 ---RALPDAPLFTAEEGTDPLALVIYTSGSTGTPKGATYSEKMVAKPWLR
Mflv_2962|M.gilvum_PYR-GCK ------------VASIRSTDAATLIYTSGTTGRPKGCQLTHSNLLYEIRG
MSMEG_2956|M.smegmatis_MC2_155 GSKARWDETLGVMPSITLNFMPMSHVMGRGILCSTLASGGTAYFAARSDL
Mvan_2578|M.vanbaalenii_PYR-1 LARSFWGD-LGVFPAITLNFMPMSHVMGRGLLYGTLDAGGTAYFAARSDL
Mb2621|M.bovis_AF2122/97 SSGWFEPS---GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYYVAKSDL
Rv2590|M.tuberculosis_H37Rv SSGWFEPS---GYPSITLNFMPMSHVGGRQVLYGTLSNGGTAYFVAKSDL
MMAR_2117|M.marinum_M RT-WFEGG---YEPSITLNFMPMSHVMGRQILYGTLCNGGTAYFVAKSDL
MUL_1722|M.ulcerans_Agy99 RT-WFEGG---YEPSITLNFMPMSHVMGRQILYGTLCNGGTAYFVVKSDL
MLBr_00484|M.leprae_Br4923 SDGNWFGP---TAASITLNFMPMSHVMGRGILYGTLGNGGTAYFAARSDL
MAV_3471|M.avium_104 GSKNWFGE---SAASITLNFMPMSHVMGRSILYGTLGNGGTAYFAARSDL
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 ADTLSSKA---EIPLINLNFMPMSHVMGRGSLVTALACGGLAYFAASSDM
Mflv_2962|M.gilvum_PYR-GCK AKACFPEH--LAKGEKLLVFLPLAHVLARALTIGAFSNG--VTLGFTSDI
MSMEG_2956|M.smegmatis_MC2_155 STFLEDLALVRPTQLNFVPRIWDMLFQEYQSRLDNRRAE----GSEDRAE
Mvan_2578|M.vanbaalenii_PYR-1 STFLEDLALVRPTQLSFVPRIWDTIHAEVSQELERRPSD----ATE----
Mb2621|M.bovis_AF2122/97 STLFEDLALVRPTELCFVPRIWDMVFAEFHSEVDRRLVD---GADRAALE
Rv2590|M.tuberculosis_H37Rv STLFEDLALVRPTELCFVPRIWDMVFAEFHSEVDRRLVD---GADRAALE
MMAR_2117|M.marinum_M STLFEDLALVRPTELTFVPRVWDMVFDEFQSEVDRRLVD---GADRVALE
MUL_1722|M.ulcerans_Agy99 STLFEDLALVRPTELTFVPRVWDMVFDEFQSEVDRRLVD---GADRVALE
MLBr_00484|M.leprae_Br4923 STLLEDLKLVRPTELNFVPRIWETLYDESKRAVDRRLANSGSA-DRAAIK
MAV_3471|M.avium_104 STLLEDLELVRPTELNFVPRIWETLYGEFQRQVERRLSEAGDAGERRAVE
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 STLFEDITLTRPTVVTLVPRVCDMLFQRYRNEVERRTGLDP-AADLATLD
Mflv_2962|M.gilvum_PYR-GCK KNLVPMFAVFQPTLVVSVPRVFEKVYN-----------------------
MSMEG_2956|M.smegmatis_MC2_155 AAVLEEVRTQLLGGRFVSALTGSAPISAEMKSWVEDLL-DMHLLEGYGST
Mvan_2578|M.vanbaalenii_PYR-1 --VIADLRRSLLGGRYVTAMTGSAPLSPEMRAFVENLL-DVHLIDGYGST
Mb2621|M.bovis_AF2122/97 AQVKAELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGST
Rv2590|M.tuberculosis_H37Rv AQVKAELRENVLGGRFVMALTGSAPISAEMTAWVESLLADVHLVEGYGST
MMAR_2117|M.marinum_M AQVKAEIRNDVLGGRYTSALTGSAPISDEMKAWVEELL-DMHLVEGYGST
MUL_1722|M.ulcerans_Agy99 AQVKAEIRNDVLGGRYTSALTGSAPISDEMKAWVEELL-DMHLVEGYGST
MLBr_00484|M.leprae_Br4923 AEVMDEQRQSLLGGRYIAAMTGSAPTSPELKHGVESLL-EMHLLEGYGST
MAV_3471|M.avium_104 AEVLAEQRQYLLGGRFTFAMTGSAPISPELRNWVESLL-EMHLMDGYGST
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 ADVKTDIRENLFGGRVLTIVCGSAPLSEELAAFIESCL-DARITDGYGST
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2956|M.smegmatis_MC2_155 EAGAVFIDGQIQRPPVIDYKLVDVPDLGYFATDRPYPRGELLVKSEQMFP
Mvan_2578|M.vanbaalenii_PYR-1 EAGAVFVDGRVQRPPVIDYKLVDVADLGYFSTDRPHPRGELLVKSETLFP
Mb2621|M.bovis_AF2122/97 EAGMVLNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFP
Rv2590|M.tuberculosis_H37Rv EAGMVLNDGMVRRPAVIDYKLVDVPELGYFGTDQPYPRGELLVKTQTMFP
MMAR_2117|M.marinum_M EAGMILIDGAIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVKTDSLFP
MUL_1722|M.ulcerans_Agy99 EAGMILIDGAIRRPAVLDYKLVDVPDLGYFLTDRPHPRGELLVKTDSLFP
MLBr_00484|M.leprae_Br4923 EAGMVLFDGEVQRPPVIDYKLVDVPDLGYFSTDQPYPRGELLLKTQNMFP
MAV_3471|M.avium_104 EAGMVLFDGEIQRPPVVDYKLVDVPDLGYFSTDRPHPRGELLLRTENMFP
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 EAGVIVRNGRIQRPPVIDYKLVDVPELGYFSTDKPHPRGELLVKAESVFG
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2956|M.smegmatis_MC2_155 GYYKRPEITAEMFDEDGYYRTGDIVAELGPDHLEYLDRRNNVLKLSQGEF
Mvan_2578|M.vanbaalenii_PYR-1 GYYKRPDVTAEMFDEDGYYRTGDIVAETGADQLTYLDRRNNVLKLSQGEF
Mb2621|M.bovis_AF2122/97 GYYQRPDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEF
Rv2590|M.tuberculosis_H37Rv GYYQRPDVTAEVFDPDGFYRTGDIMAKVGPDQFVYLDRRNNVLKLSQGEF
MMAR_2117|M.marinum_M GYYQRAEVTADVFDADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEF
MUL_1722|M.ulcerans_Agy99 GYYQRAEVTADVFDADGFYRTGDIMAEVGPEQFVYLDRRNNVLKLSQGEF
MLBr_00484|M.leprae_Br4923 GYYKRPEVTATVFDSDGYYQTGDIVAEVGPDRLVYVDRRNNVLKLAQGQF
MAV_3471|M.avium_104 GYYKRAETTAGVFDEDGYYRTGDVFAEIAPDRLVYVDRRNNVLKLAQGEF
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 GYFKRPDVTADVFDPDGYYKTGDIVAELEPDKIQIVDRRNNVIKLSQGEF
Mflv_2962|M.gilvum_PYR-GCK --------------------TAELNAETGGKGKIFTAAANTAIEYS----
MSMEG_2956|M.smegmatis_MC2_155 VTVSKLEAVFGDSPLVRQIYVYGNSARSYLLAVVVPTEEALSRW--DGDE
Mvan_2578|M.vanbaalenii_PYR-1 VTVSRLEAVFGNSPLVRQIYVYGNSARPYLLAVVVPTEAALA-----GAD
Mb2621|M.bovis_AF2122/97 IAVSKLEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRH--GIEN
Rv2590|M.tuberculosis_H37Rv IAVSKLEAVFGDSPLVRQIFIYGNSARAYPLAVVVPSGDALSRH--GIEN
MMAR_2117|M.marinum_M VTVSKLEAVFGDSPLVRQIYIYGNSARAYLLAVIVPTQEALDAV--PVEE
MUL_1722|M.ulcerans_Agy99 VTVSKLEAVFGDSPLVRQIYIYGNSARAYLLAVIVPTQEALDAV--PVEE
MLBr_00484|M.leprae_Br4923 VTVAKLEAAFSNSPLVRQIYIYGNSAHPYLLAVVVPTEDALATN--DIEV
MAV_3471|M.avium_104 VTLAKLEAVFGNSPLIRQIYVYGNSAQPYLLAVVVPTEEALASG--DPET
TH_1879|M.thermoresistible__bu --------------------------------------------------
MAB_2963|M.abscessus_ATCC_1997 VAIANLEAEFANSPLVHQICVYGSSERSYLLAVVVPTAEAYEQSGGDEDL
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2956|M.smegmatis_MC2_155 LKSRISDSLQDAARAAG-LQSYEIPRDFLVETTPFTLENGLLTGIRKLAR
Mvan_2578|M.vanbaalenii_PYR-1 AKAAVAESLQDVAKATG-LQSYEIPRDFLLETTPFTLENGLLTGIRKLAR
Mb2621|M.bovis_AF2122/97 LKPVISESLQEVARAAG-LQSYEIPRDFIIETTPFTLENGLLTGIRKLAR
Rv2590|M.tuberculosis_H37Rv LKPVISESLQEVARAAG-LQSYEIPRDFIIETTPFTLENGLLTGIRKLAR
MMAR_2117|M.marinum_M LKARLGDSLQEVAKAAG-LQSYEIPRDFIIETTPWTLENGLLTGIRKLAR
MUL_1722|M.ulcerans_Agy99 LKARLGDSLQEVAKAAG-LQSYEIPRDFIIETTPWTLQNGLLTGIRKLAR
MLBr_00484|M.leprae_Br4923 LKPLIIDSLQKVAKEAD-LQSYEVPRDLIVETTPFSLENGLLTGIRKLAW
MAV_3471|M.avium_104 LKPKIADSLQQVAKEAG-LQSYEVPRDFIIETTPFSLENGLLTGIRKLAW
TH_1879|M.thermoresistible__bu ----VGLSXQARARLADRLPAYMVPAAVVVLDRIPLTVNGKLD-RRALPA
MAB_2963|M.abscessus_ATCC_1997 LKRLIADSLAQVAREAQ-LQSYEVPRDFLLETEPFTAANGLLTGIAKLAR
Mflv_2962|M.gilvum_PYR-GCK ----------KALDSGG----------------PGLVLKLKHALFDKLVY
: *
MSMEG_2956|M.smegmatis_MC2_155 PKLKAHYGERLEQLYTDLAEGQANELRELRRNGA-DRPVVETVSRAAVAL
Mvan_2578|M.vanbaalenii_PYR-1 PRLRERYGEQLEALYTMLSEEQADELRELRRSGG-ERPALETVGRAAGAL
Mb2621|M.bovis_AF2122/97 PQLKKFYGERLERLYTELADSQSNELRELRQSGP-DAPVLPTLCRAAAAL
Rv2590|M.tuberculosis_H37Rv PQLKKFYGERLERLYTELADSQSNELRELRQSGP-DAPVLPTLCRAAAAL
MMAR_2117|M.marinum_M PQLKKHYGELLEQIYTDLAHGQADELRSLRQSGA-DAPVLVTVCRAAAAL
MUL_1722|M.ulcerans_Agy99 PQLKKHYGELLEQIYTDLAHGQADELRSLRQSGA-DAPVLVTVCRAAAAL
MLBr_00484|M.leprae_Br4923 PKLKQHYGARLEQLYADLVEGQANALHVLKQSVA-NAPVLQTVSRAVGTI
MAV_3471|M.avium_104 PKLKQHYGERLEQMYADLAAGQADELAELRRNGA-QAPVLQTVSRAAGAM
TH_1879|M.thermoresistible__bu PEYQRAD----------------------RYRAP-ETAVEKTLTEIFAHV
MAB_2963|M.abscessus_ATCC_1997 PKLHEKYGARLEQLYSDIAAAQALELQALHSAGHEDKPVLDTVQRAVTAL
Mflv_2962|M.gilvum_PYR-GCK GKLRAALG-----------------------------------GRCHAAI
. : . :
MSMEG_2956|M.smegmatis_MC2_155 LGASVTDLRSDAHFTDLGGDSLSALSFSNLLHEIFDVDVPVGVIVSPATD
Mvan_2578|M.vanbaalenii_PYR-1 LGTTAGELEPSAHFTDLGGDSLSALTFANLLRDIFDVDVPVGVIVSPATD
Mb2621|M.bovis_AF2122/97 LGSTAADVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVGVIVSPASD
Rv2590|M.tuberculosis_H37Rv LGSTAADVRPDAHFADLGGDSLSALSLANLLHEIFGVDVPVGVIVSPASD
MMAR_2117|M.marinum_M LGGSASDVQPDAHFTDLGGDSLSALSFTNLLHEIFDIEVPVGVIVSPAND
MUL_1722|M.ulcerans_Agy99 LGGSASDVQPDAHFTDLGGDSLSALSFTNLLHEIFDIDVPVGVIVSPAND
MLBr_00484|M.leprae_Br4923 LGVATTDLPSNAHFTDLGGDSLSALTFGSLLRELFDIDVPVGVIVSPVNN
MAV_3471|M.avium_104 LGSAASDLSPDAHFTDLGGDSLSALTFGNLLREIFDVDVPVGVIVSPAND
TH_1879|M.thermoresistible__bu LG--LERVGVDDSFFDLGGDSISAMRAVAAINTALDTDVAVRTLFEAP-T
MAB_2963|M.abscessus_ATCC_1997 LGLSAAEVSPDAHFIDLGGDSLSALAFSDLLRDIFTVEVPVGDIVSAAND
Mflv_2962|M.gilvum_PYR-GCK SGGAPLGARLGHFYRGVGLSIYEGYGLT---------ETSAAITVNRVGD
* . : .:* . .. :... ..
MSMEG_2956|M.smegmatis_MC2_155 LAGVAAYIE-----GELR-GSKRPTYASVHG---RDATEVRARDLALGKF
Mvan_2578|M.vanbaalenii_PYR-1 LQALADYVE-----SARRHGSVRPTFESVHGHSGRPGTEVHARDLTLDEF
Mb2621|M.bovis_AF2122/97 LRALADHIE-----AAR-TGVRRPSFASIHGRS---ATEVHASDLTLDKF
Rv2590|M.tuberculosis_H37Rv LRALADHIE-----AAR-TGVRRPSFASIHGRS---ATEVHASDLTLDKF
MMAR_2117|M.marinum_M LQALADYVE-----AARKPGSSRPTFASVHGASNGQVTEVHAGDLSLDKF
MUL_1722|M.ulcerans_Agy99 LQALADYVE-----AARKPGSSRPTFASVHGASNEQVTEVHAGDLSLDKF
MLBr_00484|M.leprae_Br4923 LVAIADYIE-----RER-QGTKRPTFIAIHGRD---AGKVHASDLTLDKF
MAV_3471|M.avium_104 LAAIASYIE-----AER-QGSKRPTFASVHGRD---ATVVRAADLTLDKF
TH_1879|M.thermoresistible__bu VRRLSRQLEGGADTAPQGADLGAVTYESVHGAT---ATEVRAADLTLDRF
MAB_2963|M.abscessus_ATCC_1997 LTAIARIVER---HREADGHSVTPTAESVHGAG---HREIRAADLTLDKF
Mflv_2962|M.gilvum_PYR-GCK LRVGS-----------------------------------------VGKL
: : :..:
MSMEG_2956|M.smegmatis_MC2_155 IDAKTLSAAPGLPRSGTEIRTVLLTGATGFLGRYLALEWLERMDLVDGKV
Mvan_2578|M.vanbaalenii_PYR-1 VDAATLAHAPTLPGPRAEVRTVLLTGATGFLGRYLALEWLERMALVGGKL
Mb2621|M.bovis_AF2122/97 IDAATLAAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKL
Rv2590|M.tuberculosis_H37Rv IDAATLAAAPNLPAPSAQVRTVLLTGATGFLGRYLALEWLDRMDLVNGKL
MMAR_2117|M.marinum_M IDAATLAEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKL
MUL_1722|M.ulcerans_Agy99 IDAATLAEAPRLPAANTQVRTVLLTGATGFLGRYLALEWLERMDLVDGKL
MLBr_00484|M.leprae_Br4923 IDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGRYLALKWLERMDLVEGKV
MAV_3471|M.avium_104 LDADTLASAPNLPKPATEVRTVLLTGATGFLGRYLALEWLERMDMVDGKV
TH_1879|M.thermoresistible__bu IDAATLRTAADLPRPTGQVQTVLLTGATGFLGRYLLLEWLRRLRRVDDTV
MAB_2963|M.abscessus_ATCC_1997 IDADTLRAAPALSTFTGTPHTVLLTGANGYLGRFLALEWLERLDKTDGKL
Mflv_2962|M.gilvum_PYR-GCK VPGNSMRLG--------EDGELLVRGGVVFNG-YWGNEEETRAVFTDGWF
: :: . :*: *. : * : : * . . .
MSMEG_2956|M.smegmatis_MC2_155 ICLVRARSDDEARARLDATFDTGDATLLEHYRALAADHLEVIAGDKGEAD
Mvan_2578|M.vanbaalenii_PYR-1 ICLVRAKDDAAARVRLDSTFDSGDPELLRHYRRLAADHLEVIAGDKADAD
Mb2621|M.bovis_AF2122/97 ICLVRARSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEAD
Rv2590|M.tuberculosis_H37Rv ICLVRARSDEEAQARLDATFDSGDPYLVRHYRELGAGRLEVLAGDKGEAD
MMAR_2117|M.marinum_M ICLVRAKSDTEARARLDKTFDSGDPELLAHYRALAGDHLEVLAGDKGEAD
MUL_1722|M.ulcerans_Agy99 ICLVRAKSDTEARARLEKTFDSGAPELLAHYRALAGDHLEVLAGDKGEAD
MLBr_00484|M.leprae_Br4923 IALVRAKSNEDARARLDKTFDSGDPKLLAHYQELATDHLEVIAGDKGEVD
MAV_3471|M.avium_104 IALVRARSDEEARARLDKTFDSGDPKLLAHYQQLAADHLEVIAGDKGEAN
TH_1879|M.thermoresistible__bu ICLVRGRSDADARQRLEAVFDT-DPALRRHFRELAAERLQVIAGDKGQPN
MAB_2963|M.abscessus_ATCC_1997 IAIVRGKNAEAAYRRLEEAFDTGDTQLLAHFRSLADKHLEVLAGDIGDPN
Mflv_2962|M.gilvum_PYR-GCK HTGDLGAIDDDG------------------FLTIVGRKKEIIVTAGGKN-
. . : : : :::. ..
MSMEG_2956|M.smegmatis_MC2_155 LGLDHDTWQRLADTVDLIVDPAALVNHVLPYSQMFGPNALGTAELIRIAL
Mvan_2578|M.vanbaalenii_PYR-1 LGLDARTWQRLADTVDLIVDPAALVNHVLPYRQLFAPNVLGTAELLRIAL
Mb2621|M.bovis_AF2122/97 LGLDRVTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLAL
Rv2590|M.tuberculosis_H37Rv LGLDRVTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNAAGTAELLRLAL
MMAR_2117|M.marinum_M LGLDRQTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLAL
MUL_1722|M.ulcerans_Agy99 LGLDRQTWQRLADTVDLIVDPAALVNHVLPYSQLFGPNALGTAELLRLAL
MLBr_00484|M.leprae_Br4923 LELDRQTWRRLADTVDLIVDPAALVNHVLPYSELFGPNTLGTAELIRIAL
MAV_3471|M.avium_104 LGLRQDVWQRLADTVDVIVDPAALVNHVLPYSELFGPNALGTAELIRLAL
TH_1879|M.thermoresistible__bu LGLDVQTWRRLAERVDLIVDSAAFVNSVLPYRELFGPNVVGTAELIRFAL
MAB_2963|M.abscessus_ATCC_1997 LGLDADTWQRLAETVDVIVHPAALVNHVLPYSQLFGPNVVGTAEIIKLAL
Mflv_2962|M.gilvum_PYR-GCK ------------------VAPAQLEDRLRAHPLISQAMAVGDQQPFIAAL
* .* : : : .: : . . * : : **
MSMEG_2956|M.smegmatis_MC2_155 TTTIKPYVYVSTIGVGQGISPEAFVEDADIREISATRRVDDSYANGYGNS
Mvan_2578|M.vanbaalenii_PYR-1 TTRMKPFVYVSTIGVGAGIEPARFTEDADIRQISATRRIDDSYANGYGNS
Mb2621|M.bovis_AF2122/97 TGKRKPYIYTSTIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANS
Rv2590|M.tuberculosis_H37Rv TGKRKPYIYTSTIAVGEQIPPEAFTEDADIRAISPTRRIDDSYANGYANS
MMAR_2117|M.marinum_M TSKIKPYSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNS
MUL_1722|M.ulcerans_Agy99 TSKIKPYSYTSTIGVADQIPPSAFTEDADIRVISATRAVDDSYANGYSNS
MLBr_00484|M.leprae_Br4923 TSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISPTRNINNNYANGYGNS
MAV_3471|M.avium_104 TSKQKPYTYVSTIGVGDQIEPGKFVENADIRQMSATRAINDSYANGYGNS
TH_1879|M.thermoresistible__bu TAKLKPYNFVSTSDIGRQIEPDLFTEDADIRTISPTRTVDASYANGYGNS
MAB_2963|M.abscessus_ATCC_1997 TTKIKPITYLSTVAVAISVDPKVFDEDSDIRTISAVRPINDGYANGYGNA
Mflv_2962|M.gilvum_PYR-GCK IT----------------VDTEAFPGWKERHHKASDASVADLADD-----
: . * : : :. : :
MSMEG_2956|M.smegmatis_MC2_155 KWAGEVLLREAHDWCGLPVSVFRCDMILADTTYSGQLNLPDMFTRLMLSL
Mvan_2578|M.vanbaalenii_PYR-1 KWAGEVLLREAHDLCGLPVSVFRCDMILADTTYAGQLNLPDMFTRLIFSL
Mb2621|M.bovis_AF2122/97 KWAGEVLLREAHEQCGLPVTVFRCDMILADTSYTGQLNLPDMFTRLMLSL
Rv2590|M.tuberculosis_H37Rv KWAGEVLLREAHEQCGLPVTVFRCDMILADTSYTGQLNLPDMFTRLMLSL
MMAR_2117|M.marinum_M KWAGEVLLREAHDLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSL
MUL_1722|M.ulcerans_Agy99 KWAGEVLLREAHVLCGLPVAVFRCDMILADTTWAGQLNVPDMFTRMILSL
MLBr_00484|M.leprae_Br4923 KWAGEVLLREAHDLCGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSL
MAV_3471|M.avium_104 KWAGEVLLREAHDLCGLPVAVFRCDMILADTTYAGQLNLPDMFTRLMLSL
TH_1879|M.thermoresistible__bu KWAGEVLLREAHDLCGLPVAVFRSGMILVDPTYAGQLNVTDTVSRMVLSI
MAB_2963|M.abscessus_ATCC_1997 KWAGEVLLREAHDLCGLPVAVFRSDMILAHSRYTGQLNVPDQFTRLILSL
Mflv_2962|M.gilvum_PYR-GCK ---------------------------------------PDLLAEIELAV
.* .:.: :::
MSMEG_2956|M.smegmatis_MC2_155 VATGIAPGSFYELDADGNRQRAHYDGLPVEFIAEAISTIGSQ---VTDG-
Mvan_2578|M.vanbaalenii_PYR-1 VATGVAPESFYHLATDGTRQRAHYDGLPVEFIAEAISTLGSD---VASG-
Mb2621|M.bovis_AF2122/97 AATGIAPGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTH---SPDR-
Rv2590|M.tuberculosis_H37Rv AATGIAPGSFYELDAHGNRQRAHYDGLPVEFVAEAICTLGTH---SPDR-
MMAR_2117|M.marinum_M AATGIAPGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ---SQDG-
MUL_1722|M.ulcerans_Agy99 AATGIAPGSFYELAADGARQRAHYDGLPVEFIAEAISTLGAQ---SQDG-
MLBr_00484|M.leprae_Br4923 AATGIAPGSFYELDAESNRQRAHYDGLPVEFIAEAISTLGDQSLHDRDG-
MAV_3471|M.avium_104 VATGIAPGSFYELDADGNRQRAHYDGLPVEFIAAAISTLGSQITDSDTG-
TH_1879|M.thermoresistible__bu VATGVAPKSFYRLGDDGSRQRAHFDGLPVDFVAEAVATLGWQIARTATGS
MAB_2963|M.abscessus_ATCC_1997 IATGVAPGSFYQAHATGERPLAHYDGLPADFTASAITALGPIEE------
Mflv_2962|M.gilvum_PYR-GCK KDANQAVSKAEAIR--------KFRILPVDFTED----------------
:. * . :: **.:*
MSMEG_2956|M.smegmatis_MC2_155 ----FETFHVMNPYDDGIGLDEYVDWLIE----AGYPVHRVDDYATWLSR
Mvan_2578|M.vanbaalenii_PYR-1 ----FRTYHVMNPHDDGIGLDEYVDWLID----AGHPIRRVGDYPTWLQR
Mb2621|M.bovis_AF2122/97 ----FVTYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQR
Rv2590|M.tuberculosis_H37Rv ----FVTYHVMNPYDDGIGLDEFVDWLNSPTSGSGCTIQRIADYGEWLQR
MMAR_2117|M.marinum_M ----FHTYHVMNPYDDGIGLDEFVDWLNE----SGCPIQRIADYGDWLQR
MUL_1722|M.ulcerans_Agy99 ----FHTYHVMNPYDDGIGLDEFVDWLNE----SGCPIQRIADYGDWLQR
MLBr_00484|M.leprae_Br4923 ----FTTYHVMNPHDDGIGMDEFVDWLID----AGCPIQRINDYDEWLRR
MAV_3471|M.avium_104 ----FQTYHVMNPYDDGIGLDEYVDWLVD----AGYSIERIADYSEWLRR
TH_1879|M.thermoresistible__bu PAGDFRTYHVMNPHDDGIGIDEYVDWLIE----AGHPIERIDDFGEWLRR
MAB_2963|M.abscessus_ATCC_1997 ----FHTYDSVNPHADGISLDNFVDWLIE----AGYPIARIDNYTEWFTR
Mflv_2962|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2956|M.smegmatis_MC2_155 FETALRALPERQRQASLLPLLHNYQQ------PSPPVCGAMAPTDRFRAA
Mvan_2578|M.vanbaalenii_PYR-1 FTVAITALPERQRQASLLPLLHNYQH------PETPIRGSIAPTDRFREA
Mb2621|M.bovis_AF2122/97 FETSLRALPDRQRHTSLLPLLHNYRE------PAKPICGSIAPTDQFRAA
Rv2590|M.tuberculosis_H37Rv FETSLRALPDRQRHASLLPLLHNYRE------PAKPICGSIAPTDQFRAA
MMAR_2117|M.marinum_M FETALRALPDRQRHSSLLPLLHNYRQ------PERPVRGSIAPTDRFRAA
MUL_1722|M.ulcerans_Agy99 FETALRALPDRQRHSSLLPLLHNYRQ------PERPVRGSIAPTDRFRAA
MLBr_00484|M.leprae_Br4923 FEISLRALPERQRHSSLLPLLHNYQK------PEKPLHGSLAPTIRFRTA
MAV_3471|M.avium_104 FETSLRALPDRQRQYSLLPLLHNYRT------PEKPINGSIAPTDVFRAA
TH_1879|M.thermoresistible__bu FEAGLHALPERQRQHSVLQMLTLLRQQGGEPQPPEPRHGSDAPADRFEAA
MAB_2963|M.abscessus_ATCC_1997 FDTAIRSLPEKQKQHSLLPLLHAYRH------PQHPHNGAFLPAIRFSEG
Mflv_2962|M.gilvum_PYR-GCK -------------------------------------TGELTPTLKVKRK
* *: .
MSMEG_2956|M.smegmatis_MC2_155 VQDAKIGPDKDIPHVTADVIVKYISNLQMLGLL
Mvan_2578|M.vanbaalenii_PYR-1 VQDAKIGPDKDIPHVTPQIVIKYVTDLQRLGLL
Mb2621|M.bovis_AF2122/97 VQEAKIGPDKDIPHLTAAIIAKYISNLRLLGLL
Rv2590|M.tuberculosis_H37Rv VQEAKIGPDKDIPHLTAAIIAKYISNLRLLGLL
MMAR_2117|M.marinum_M VQEAKIGPDKDIPHVGAPIIVKYVSDLRLLGLL
MUL_1722|M.ulcerans_Agy99 VQEAKIGPDKDIPHVGAPIIVKYVSDLRLLGLL
MLBr_00484|M.leprae_Br4923 VQNANIGQDKDIPHISPAIIAKYVSDLQLLGLV
MAV_3471|M.avium_104 VQEAKIGPDKDIPHVSPPVIVKYITDLQLLGLL
TH_1879|M.thermoresistible__bu VKRAGINGGQGIPHVTPEVIVRYVTDLRQLGLL
MAB_2963|M.abscessus_ATCC_1997 VQAHLN---ADIPHLTRELIAKYAADLKQLGLL
Mflv_2962|M.gilvum_PYR-GCK VVAEKFAADIEALYAKG----------------
* :