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SPRITLNDGNSIPQVGLGVWQTPAEDTERAVAAALQAGYRHIDTAAAYRNETETGRAIANSGVPREDIFL VTKLWNSDQGYDATLAAFDASVQRLGVDYLDLYLIHWPVPENNKFVDTFKAFAHLRDQGRIRSIGVSNFE PEHLTTLIEETGIVPAVNQIELHPLLPQQELRDVHAKLGIATEAWSPLGQGSLLADPVITGIAEQHGKTP AQVLIRWHIQLGNIVIPKSVNPERIASNFDVFDFELSGQDITSIASLETGKRLGPDPRTFNFTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2408 | - | - | 100% (275) | 2,5-diketo-D-gluconic acid reductase A |
| M. smegmatis MC2 155 | MSMEG_2407 | - | 1e-82 | 55.02% (269) | morphine 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6730 | - | 8e-14 | 25.65% (269) | putative oxidoreductase YdbC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2996 | - | 6e-79 | 53.33% (270) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4205 | - | 1e-83 | 55.93% (270) | 2,5-didehydrogluconate reductase |
| M. tuberculosis H37Rv | Rv2971 | - | 4e-78 | 52.96% (270) | oxidoreductase |
| M. leprae Br4923 | MLBr_01669 | - | 5e-77 | 52.04% (269) | putative oxidoreductase of Aldo/keto reductase family |
| M. abscessus ATCC 19977 | MAB_1528c | - | 8e-96 | 61.71% (269) | oxidoreductase |
| M. marinum M | MMAR_1744 | - | 2e-77 | 52.22% (270) | oxidoreductase |
| M. avium 104 | MAV_4483 | - | 2e-79 | 52.42% (269) | 2,5-diketo-D-gluconic acid reductase B |
| M. thermoresistible (build 8) | TH_1364 | - | 3e-84 | 54.68% (267) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1987 | - | 1e-76 | 51.48% (270) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2161 | - | 9e-81 | 54.28% (269) | 2,5-didehydrogluconate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1744|M.marinum_M -MPG----APSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEI
MUL_1987|M.ulcerans_Agy99 MMPG----APSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEI
Mb2996|M.bovis_AF2122/97 MTGE----SGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEI
Rv2971|M.tuberculosis_H37Rv MTGE----SGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEI
MLBr_01669|M.leprae_Br4923 MMPS----TPRTSIPSITLNDENTMPLLGLGVAELSEDETERAVLAALEI
MAV_4483|M.avium_104 MTVIDEIYSSSSAIPTVALNDEAKMPVLGLGVAKLSDEETESSVLAALEA
Mflv_4205|M.gilvum_PYR-GCK MTS-------AAAIPTVTLNDDNTMPVIGLGVGELSDAETEQAVTAALEA
Mvan_2161|M.vanbaalenii_PYR-1 MTS-------AAAIPTVILNDDNTMPVIGLGVGELSDAEAEQSVLAALEA
TH_1364|M.thermoresistible__bu MTSSP---GEAAATPTVTLNDDRSMPVLGLGVGELSDDEAERAVAAALEA
MSMEG_2408|M.smegmatis_MC2_155 ------------MSPRITLNDGNSIPQVGLGVWQTPAEDTERAVAAALQA
MAB_1528c|M.abscessus_ATCC_199 ----------------MTLNSGTTIPQLGYGVWQVPDDQARAAVSAALQV
: **. .:* :* ** . ::. :* ***:
MMAR_1744|M.marinum_M GCRLIDTAAAYGNEAAVGRAIAASGIPRAELFVTTKVATADHGFTASREA
MUL_1987|M.ulcerans_Agy99 GCRLIDTAAAYGNEAAVGRALAASGIPRAELFVTTKVATADHGFTASREA
Mb2996|M.bovis_AF2122/97 GCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEA
Rv2971|M.tuberculosis_H37Rv GCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEA
MLBr_01669|M.leprae_Br4923 GCRLIDTAAAYGNEAAVSRAIAASGIPRAQLFVTTKLATPDQGFTKSQDA
MAV_4483|M.avium_104 GCRLIDTAASYGNEAAVGRAIAASGIPREELFVTTKLGTSRQGFHSAQES
Mflv_4205|M.gilvum_PYR-GCK GYRLIDTAAAYGNEAAVGRAIAASGVPRDELFVTTKLATEDAGFQSSQDA
Mvan_2161|M.vanbaalenii_PYR-1 GYRLIDTAAAYGNEAAVGRAIAKSGVPRGELFVTTKLATDDLGFQSSQDA
TH_1364|M.thermoresistible__bu GYRLIDTAASYGNEAGVGRAIAASGLPREEIFVTTKLATTDQGFQSSQDA
MSMEG_2408|M.smegmatis_MC2_155 GYRHIDTAAAYRNETETGRAIANSGVPREDIFLVTKLWNSDQGYDATLAA
MAB_1528c|M.abscessus_ATCC_199 GYRSIDTAKIYDNEAGTGAAIAESGIPRGDVFLTTKLWNSDQGYDNALRA
* * **** * **: .. *:* **:.* ::*:.**: . *: : :
MMAR_1744|M.marinum_M CKASLDRLGLDYVDLYLIHWPAPAAGKYVDAFGGLIQARGEGFTRSIGVS
MUL_1987|M.ulcerans_Agy99 CKASLDRLGLDYVDLYLIHWPAPAVGKYVDAFGGLIQARGEGFTRSIGVS
Mb2996|M.bovis_AF2122/97 CRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVS
Rv2971|M.tuberculosis_H37Rv CRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVS
MLBr_01669|M.leprae_Br4923 CNASLDRLGMDYVDLYLIHWPAPPVGQYVDAWGGMIQSRGEGHARSIGVC
MAV_4483|M.avium_104 CKESLDRLGLDYLDLYLIHWPAPKLGKYVESFEGMIEARERGHVRSIGVS
Mflv_4205|M.gilvum_PYR-GCK LRASLERLGLDYVDLYLIHWPVSQQGKHVDSWGGLMKSKEVGLTRSIGVA
Mvan_2161|M.vanbaalenii_PYR-1 LRASLERLGLDYVDLYLIHWPAGSQGTYVDSWGGLMKLKELGLTRSIGVS
TH_1364|M.thermoresistible__bu VRASLERLGLEYVDLYLIHWPAGEQGKYVDSWGGFLKIREDGLTRSIGVS
MSMEG_2408|M.smegmatis_MC2_155 FDASVQRLGVDYLDLYLIHWPVPENNKFVDTFKAFAHLRDQGRIRSIGVS
MAB_1528c|M.abscessus_ATCC_199 FDASLERLGTDYVDLYLIHWPVPELDEYVASFKALQRIQADGRAKAIGVS
*::*** :*:********. . .* :: .: . : * ::***.
MMAR_1744|M.marinum_M NFTEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTP
MUL_1987|M.ulcerans_Agy99 NFTEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTP
Mb2996|M.bovis_AF2122/97 NFTAEHIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCP
Rv2971|M.tuberculosis_H37Rv NFTAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCP
MLBr_01669|M.leprae_Br4923 NFTEEHLSAIIDLTFVTPAVNQIELHPLLNQDEMRKSNAQHNVITQSYTP
MAV_4483|M.avium_104 NFTEDLLATVIEETDEVPAVNQVELHPRLNQAELRQVHAQHDVTTQSYSP
Mflv_4205|M.gilvum_PYR-GCK NFHGHHLDDIISLSFFTPAVNQIELHPLLNQAELRAVNAEHGIATEAYGP
Mvan_2161|M.vanbaalenii_PYR-1 NFHAQHLDDIIGLSFFTPAVNQIELHPLLNQAELRAVNAEHGIVTEAYSP
TH_1364|M.thermoresistible__bu NFDEEYLSDIIDLSFVTPAVNQIELHPLLNQADLRKVHAERNVLTQAYSP
MSMEG_2408|M.smegmatis_MC2_155 NFEPEHLTTLIEETGIVPAVNQIELHPLLPQQELRDVHAKLGIATEAWSP
MAB_1528c|M.abscessus_ATCC_199 NFTVDNLKRLIDETGEVPALNQIELHPRFTQPELRAFHAEYGIATEAWSP
** . : :* : .**:**:**** : * ::* :*: : *::: *
MMAR_1744|M.marinum_M LALGQLADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIAT
MUL_1987|M.ulcerans_Agy99 LALGQLADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIVT
Mb2996|M.bovis_AF2122/97 LALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIAS
Rv2971|M.tuberculosis_H37Rv LALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIAS
MLBr_01669|M.leprae_Br4923 LVLGRLMDNSTLTAIAAEYGKTPAQVLLRWNLQLGNAVVFRSAKAEHIAS
MAV_4483|M.avium_104 LGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVSRSSKPERVAE
Mflv_4205|M.gilvum_PYR-GCK LGVGNLLSHSAVNAIAEAHGRTPAQVLIRWSLQLGNIVIPRSSSPERIRS
Mvan_2161|M.vanbaalenii_PYR-1 LGVGSLLSNPAVTAIADAQDRTPAQVLIRWSLQLGNVVISRSSSPERIKS
TH_1364|M.thermoresistible__bu LGVGNLLADPTIGAVAQAHGKSPAQVLLRWNLQLGNAVVVRSSNPDRMRE
MSMEG_2408|M.smegmatis_MC2_155 LGQGSLLADPVITGIAEQHGKTPAQVLIRWHIQLGNIVIPKSVNPERIAS
MAB_1528c|M.abscessus_ATCC_199 LGQGTILEDATIGAIAQAHDVSAAQVILRWHLQLGNVVIPKSVTPARIAA
* * : ...: :* :.:**::** :**.* *: * . ::
MMAR_1744|M.marinum_M NLDVFEFELASQHMDAINGLNDG-TRLREDP-------------MTFAGV
MUL_1987|M.ulcerans_Agy99 NLDVFEFELASQHMDAINGLNDG-TRLREDP-------------MTFAGV
Mb2996|M.bovis_AF2122/97 NFDVFDFELAAEHMDALGGLNDG-TRVREDP-------------LTYAGT
Rv2971|M.tuberculosis_H37Rv NFDVFDFELAAEHMDALGGLNDG-TRVREDP-------------LTYAGT
MLBr_01669|M.leprae_Br4923 NFDVFDFELAVNHMDAMNELHDG-TRLRPDP-------------ETYAGS
MAV_4483|M.avium_104 NLDVFDFTLEPEHMEAIEGLHDG-TRVLHDP-------------MTFMGT
Mflv_4205|M.gilvum_PYR-GCK NIDVFGFELSEEQMSTLNGLDDG-TRFRPDP-------------ETYSGS
Mvan_2161|M.vanbaalenii_PYR-1 NLDVFDFELTADQMAALDGLDEG-TRFRPDP-------------ETYTGS
TH_1364|M.thermoresistible__bu NLAVFDFELTDDEMNTINGMDNG-TRYRPDPXXGEGAAAEHQSADSAAGT
MSMEG_2408|M.smegmatis_MC2_155 NFDVFDFELSGQDITSIASLETG-KRLGPDP-------------RTFNFT
MAB_1528c|M.abscessus_ATCC_199 NFDVFGFELSTDEVERITALDASDGRIGPDP-------------TTFNLH
*: ** * * :.: : :. . * ** :
MMAR_1744|M.marinum_M -------------------------------------------
MUL_1987|M.ulcerans_Agy99 -------------------------------------------
Mb2996|M.bovis_AF2122/97 -------------------------------------------
Rv2971|M.tuberculosis_H37Rv -------------------------------------------
MLBr_01669|M.leprae_Br4923 -------------------------------------------
MAV_4483|M.avium_104 -------------------------------------------
Mflv_4205|M.gilvum_PYR-GCK -------------------------------------------
Mvan_2161|M.vanbaalenii_PYR-1 -------------------------------------------
TH_1364|M.thermoresistible__bu AVPGHPVRRGGCARRQRRPGTAADHLLHRRSDGLSVEQVDHQR
MSMEG_2408|M.smegmatis_MC2_155 G------------------------------------------
MAB_1528c|M.abscessus_ATCC_199 -------------------------------------------