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ISTKLTVAGLQSAGSPANPEANLAELDQAAKRLAGQADLLITPELFVTGYDVGDRLPELVSAHHLDAVRA IAEQNKIAIIVGMAESVAAGELYNNAVFVDERGVVRGRHHKTHLFGEIDRAYFTPGSHAVTMVPYRGVNI AMMICYDVEFPENARMSALAGAHLLAVPTAQMTPFEFVADVVIRTRAWENQIYLAYINHDGVENATTYVG RSSIVGPDGGVLDRIESGTGTIIAEIDTDVVRSAQRANPYLTDTRPELNSALTAGGGCVTWSNNG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2922c | - | - | 100% (276) | carbon-nitrogen hydrolase family protein/ nitrilase/cyanide hydratase |
| M. abscessus ATCC 19977 | MAB_4348c | - | 5e-86 | 62.12% (264) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0819 | - | 9e-47 | 38.04% (255) | carbon-nitrogen hydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0490c | - | 2e-11 | 27.17% (265) | hypothetical protein Mb0490c |
| M. gilvum PYR-GCK | Mflv_0095 | - | 2e-08 | 24.81% (258) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv0480c | - | 3e-11 | 27.60% (250) | amidohydrolase |
| M. leprae Br4923 | MLBr_02449 | - | 6e-09 | 24.80% (250) | putative hydrolase |
| M. marinum M | MMAR_0805 | - | 3e-10 | 25.88% (255) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 7e-15 | 27.71% (249) | carbon-nitrogen hydrolase |
| M. smegmatis MC2 155 | MSMEG_6733 | - | 5e-26 | 33.46% (257) | hydrolase, carbon-nitrogen family protein |
| M. thermoresistible (build 8) | TH_0873 | - | 1e-11 | 27.57% (243) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4548 | - | 8e-10 | 25.49% (255) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_1219 | - | 5e-18 | 29.39% (262) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0805|M.marinum_M -------------------------------MRIALAQILSG---TDPTA
MUL_4548|M.ulcerans_Agy99 -------------------------------MRIALAQILSG---TDPTA
MLBr_02449|M.leprae_Br4923 -------------------------------MRIALAQILSG---TDPVA
Mb0490c|M.bovis_AF2122/97 MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSG---TDPAA
Rv0480c|M.tuberculosis_H37Rv -------------------------------MRIALAQIRSG---TDPAA
MAV_4670|M.avium_104 -------------------------------MRIALAQILSG---TDPAA
Mflv_0095|M.gilvum_PYR-GCK ---------------------------MRSGMRIALAQIQSS---TDPAA
TH_0873|M.thermoresistible__bu -------------------------------MRIALAQIRSG---TDPSA
MSMEG_6733|M.smegmatis_MC2_155 -------------------------------MRTVDVAVVQEPA-VAGDV
Mvan_1219|M.vanbaalenii_PYR-1 -------------------------------MKVGAVAAHFG---RDVDR
MAB_2922c|M.abscessus_ATCC_199 ----------------------------MISTKLTVAGLQSAGSPANPEA
: .
MMAR_0805|M.marinum_M NLELVRDYAERAADAGARLVVFPEATMC--RFGVPLGPVAQP---LDGPW
MUL_4548|M.ulcerans_Agy99 NLELVRDYAERAADAGARLVVFPEATMC--RFGVPLGPVAQP---LDGPW
MLBr_02449|M.leprae_Br4923 NLRLVREYTGQATDAGATLVVFPEATMC--RFGVPLGPVAEP---IDGPW
Mb0490c|M.bovis_AF2122/97 NLQLVGKYAGEAATAGAQLVVFPEATMC--RLGVPLRQVAEP---VDGPW
Rv0480c|M.tuberculosis_H37Rv NLQLVGKYAGEAATAGAQLVVFPEATMC--RLGVPLRQVAEP---VDGPW
MAV_4670|M.avium_104 NLALVGEYTRRAAGAGARLVVFPEATMC--RFGVPLAPIAEP---VDGPW
Mflv_0095|M.gilvum_PYR-GCK NLTLVEEYTRRAVDAGASLVLFPEATMV--RFGVPLGGVAEP---FDGPW
TH_0873|M.thermoresistible__bu NLNLVEEYTRRAAATGAGLVLFPEATMC--RFGVSLKPVAEP---LDGPW
MSMEG_6733|M.smegmatis_MC2_155 AANVRRAVAALAKHPGADLVVFPELFLCGYRLDVVADAAIEM---IPEPG
Mvan_1219|M.vanbaalenii_PYR-1 GVAKVVGIVEAAARDGVQLLVFPDACLGGYIGDLRRPDPSDPPPALDPDG
MAB_2922c|M.abscessus_ATCC_199 NLAELDQAAKRLAGQ-ADLLITPELFVTGYDVGDRLPELVSA------HH
. . *:: *: : . .
MMAR_0805|M.marinum_M ANGVRRIAAQTGITVVAGMFTPADAGRVSNTLFAAGPGAPNQPDDHYHKI
MUL_4548|M.ulcerans_Agy99 ANGVRRIAAQTGITVVAGMFTPADAGRVSNTLFAAGPGAPNQPDDHYHKI
MLBr_02449|M.leprae_Br4923 ANGVRQIATEAGITIIAGIFTPADDGRVMNTLIAAGPGTPNQPDTHYHKI
Mb0490c|M.bovis_AF2122/97 ANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDAHYHKI
Rv0480c|M.tuberculosis_H37Rv ANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDAHYHKI
MAV_4670|M.avium_104 ADGVRRIATEANVTVIAGMFTPSGDGRVKNTLLVAN--SDDQAVTHYDKI
Mflv_0095|M.gilvum_PYR-GCK ANAVRDIAARAGIVVVAGMFVPSDDGRSFNTLLATGPGVEAR----YDKI
TH_0873|M.thermoresistible__bu ATAVREIAAGAGVVVVAGMFTPSGDGRVTNTLLATGPGVAAH----YHKI
MSMEG_6733|M.smegmatis_MC2_155 PVADLCAAAAAHDTAVVTGFAERSGDLVYNSLLCIDRTGAVAG--VYRKT
Mvan_1219|M.vanbaalenii_PYR-1 PEIAAVIAAAGPMTVCVGYAEAAPGGSRYNSAICVSGDGVLG---THRKV
MAB_2922c|M.abscessus_ATCC_199 LDAVRAIAEQNKIAIIVGMAESVAAGELYNNAVFVDERGVVRG--RHHKT
* . . . *. . . : *
MMAR_0805|M.marinum_M HLYDAFGFAESRTVAPGHEPVVITVDD----VQVGLTVCYDIRFPALYTE
MUL_4548|M.ulcerans_Agy99 HLYDAFGFAESRTVAPGHEPVVITVDD----FQVGLTVCYDIRFPALYTE
MLBr_02449|M.leprae_Br4923 HLYDAFGFTESRTVTAGHEPVVITVDD----VQVGLTICYDIRFPALYTE
Mb0490c|M.bovis_AF2122/97 HLYDAFGFTESRTVAPGREPVVVVVDG----VRVGLTVCYDIRFPALYTE
Rv0480c|M.tuberculosis_H37Rv HLYDAFGFTESRTVAPGREPVVVVVDG----VRVGLTVCYDIRFPALYTE
MAV_4670|M.avium_104 HLYDAFGFTESRTVAPGREPVVVGVDG----VRVGLSVCYDIRFPELYTE
Mflv_0095|M.gilvum_PYR-GCK HLYDAFGFLESKTVAPGREPVVISVDTESGPVTVGLTLCYDIRFPELYVE
TH_0873|M.thermoresistible__bu HLYDAYGFTESRTVAPGSEPVTIDVGG----VRVGLTTCYDIRFPELYVE
MSMEG_6733|M.smegmatis_MC2_155 HLFG----AECEAFATGDRLEVIEVDG----LRVGPMICFDVEFPEIART
Mvan_1219|M.vanbaalenii_PYR-1 HQPAG----ESLAYLAGDTFAAFDTPVG----RLGMLIDYDKTFPESARA
MAB_2922c|M.abscessus_ATCC_199 HLFG---EIDRAYFTPGSHAVTMVPYRG---VNIAMMICYDVEFPENARM
* : .* .. :. :* **
MMAR_0805|M.marinum_M LARRGAELIVVSASWGSGPGKLDQWTLLARARALDSASYVAAAGQADPGD
MUL_4548|M.ulcerans_Agy99 LARRGAELIVVSASWGSGPGKLDQWTLLARARALDSASYVAAAGQADPGD
MLBr_02449|M.leprae_Br4923 LARRGAQLIVVCASWGSGAGKLEQWTLLARARALDSMSYVAAVGQADPGG
Mb0490c|M.bovis_AF2122/97 LARRGAQLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGD
Rv0480c|M.tuberculosis_H37Rv LARRGAQLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAAGQADPGD
MAV_4670|M.avium_104 LARRGAQLIAVCASWGAGPGKLDQWTLLARARALDSMSYIAAAGQADPGG
Mflv_0095|M.gilvum_PYR-GCK LADRGAEIITAHASWGTGPGKLEQWTLLARARAIDTSSVVAAVGQAYPGD
TH_0873|M.thermoresistible__bu LARRGAELLTVHASWGSGPGKLEQWTLLARARALDTTCVVAAVGQAYPGD
MSMEG_6733|M.smegmatis_MC2_155 LALSGVDLFVVSSANMFPYHHDHRVACLSRALENRTPLVYSNLIGAEAG-
Mvan_1219|M.vanbaalenii_PYR-1 LALDGAHIIAALSAWPASVTDRASRLPADRQSRLFDLYDCARAAENQVVV
MAB_2922c|M.abscessus_ATCC_199 SALAGAHLLAVPTAQMTPFEFVADVVIRTRAWENQIYLAYINHDGVENAT
* *..::.. :: *
MMAR_0805|M.marinum_M TASDPGGGSGAPRGVGGSLVASPLGEVVASAGSDPQLVVADIDLAKVGA-
MUL_4548|M.ulcerans_Agy99 TASDPGGGSGAPRGVGGSLVTSPLGEVVASAGSDPQLVVADIDLAKVGA-
MLBr_02449|M.leprae_Br4923 ALTDSGPSSAAPTGVGGSLVASPLGEVVASAGTESKLVVADIDVDNVTT-
Mb0490c|M.bovis_AF2122/97 ARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAA-
Rv0480c|M.tuberculosis_H37Rv ARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQPQLLVADIDVDNVAA-
MAV_4670|M.avium_104 SLS----ASGAPTGVGGSLVASPLGEVVASAGAQPQLVLADIDVDRVAQ-
Mflv_0095|M.gilvum_PYR-GCK EIAALG-----PTGVGGSLVASALGEVLASAGDDPELLVCDVDLEAARK-
TH_0873|M.thermoresistible__bu EIAAQG-----PTGVGGSLVASATGEVLAAAGPEPELLVADLDLDAARR-
MSMEG_6733|M.smegmatis_MC2_155 -----------LTFVGGSRVVDAGGELLVECGGEVSVARCRVTPATATS-
Mvan_1219|M.vanbaalenii_PYR-1 VSANQTGIMGSLRFLGQAKVVGPGGDVLATTRSKGGLARVDIDVEAEIAR
MAB_2922c|M.abscessus_ATCC_199 ------------TYVGRSSIVGPDGGVLDRIESGTGTIIAEIDTDVVRS-
:* : :... * :: :
MMAR_0805|M.marinum_M ARDNIGVLRNQSRFTQTDKAQSRR--------
MUL_4548|M.ulcerans_Agy99 ARDNIGMLRNQSRFTQTDKAQSRR--------
MLBr_02449|M.leprae_Br4923 ARENIAVLRNRSHFA-----------------
Mb0490c|M.bovis_AF2122/97 ARDRIAVLRNQTDFVQIDKAQSRG--------
Rv0480c|M.tuberculosis_H37Rv ARDRIAVLRNQTDFVQIDKAQSRG--------
MAV_4670|M.avium_104 ARKTIAALSNRSDFAQVGRAESVG--------
Mflv_0095|M.gilvum_PYR-GCK ARQTVAVMQNRSGFAHRGKAESRG--------
TH_0873|M.thermoresistible__bu ARDTIAVLRNRSDVAQWGKAESVG--------
MSMEG_6733|M.smegmatis_MC2_155 TEDDVDYLRHRRPELYRLK-------------
Mvan_1219|M.vanbaalenii_PYR-1 ARRVLDHLAERRVDTYSTTARS----------
MAB_2922c|M.abscessus_ATCC_199 AQRANPYLTDTRPELNSALTAGGGCVTWSNNG
:. : .