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MPLPIGAPAQKNEGVGVKNSNQLQQRALKAVTAQLPIDIDGSNVIVEDGLSYTRSPIKAHDYATGLFSAF GGAVEYLGRMRGLPAQTLTVNRRLSGLSLNSLQLTFSNGRALGFDDYTTGPDNGIYRTRDNRFFGMIGLH PKLRDGITEYLGATSREGLRRAISQRDAQDLEDSFAQRRLPGGIVRTPQEWLDHPQGRACAEHPMVLVDQ LSKGGSHRRLGNATVRPLEGVRVVELANVVAGPTTGRALAEQGAEVIKLACVGGPVTIGIWLDANWGKRQ FRMNIKGPAGQAKLRELLAGADVLLNSMSPGRLTELGLGPEALQQINPNLILADFSFAPKNSPWFDRKGF EQIAQSVSGIVSVNSQDRYVDDPTHISVLINDFCSAYNLATGIVSALAAREEQGGFWYVEHSLLRNATEA VRYVRPMNDERYAPVSIADLRRWAIDQDTPNGVFTRLTPPVTFSHTPSKAWRPTGLPFGGVEGLSWQDKP IGSDDPLATPHYPSRIVAEGRLHDFVECYGIEDRGDGGGDVSFFSPGLAVLSRNQGLEAI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2765 | - | - | 100% (550) | putative L-carnitine dehydratase |
| M. abscessus ATCC 19977 | MAB_1889 | - | 7e-23 | 28.18% (291) | L-carnitine dehydratase |
| M. abscessus ATCC 19977 | MAB_4651c | - | 4e-18 | 29.29% (198) | putative L-carnitine dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 7e-19 | 30.73% (192) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4465 | - | 4e-18 | 27.72% (202) | Formyl-CoA transferase |
| M. tuberculosis H37Rv | Rv3272 | - | 7e-19 | 30.73% (192) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0311 | - | 1e-18 | 29.35% (201) | hypothetical protein MMAR_0311 |
| M. avium 104 | MAV_1892 | - | 8e-22 | 33.65% (208) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_2023 | - | 4e-25 | 37.04% (189) | CAIB/BAIF family protein |
| M. thermoresistible (build 8) | TH_4358 | - | 1e-21 | 29.82% (228) | PUTATIVE caib/baif family protein |
| M. ulcerans Agy99 | MUL_4811 | - | 7e-19 | 30.26% (195) | hypothetical protein MUL_4811 |
| M. vanbaalenii PYR-1 | Mvan_1895 | - | 4e-19 | 28.22% (202) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu MLWRIAEMFFSKELPRMVAISGSHAAPEPSAPLAGIRVVDLSTTLPGAFC
MAB_2765|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu TQFLADSGADVLMVEPPEGSPVRTLRGWPAFGRGKRSRVLDLKAPGGVTE
MAB_2765|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu LDEVLRGADVMVTTFSPAALTALGVDSNALSERHPRLVSAHITGWGRSGP
MAB_2765|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu WRDLKGYEGLVLAKAGFSHAVRRMAQPPRPSYVATPYASYAAGHIAVHGI
MAB_2765|M.abscessus_ATCC_1997 -------------------------------------------------M
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu LAALHEREHSGLGQIVDADLVRGVHAIDAWTWFGELVGIRWPEAYSSVEA
MAB_2765|M.abscessus_ATCC_1997 PLPIGAPAQKNEGVGVKNSNQLQQRALKAVTAQLPIDIDGSNVIVEDGLS
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu WTEQGTPQSPMLLALLAAPTKDGHWLQFAQVQPHLFTAMLTEFGVMELLE
MAB_2765|M.abscessus_ATCC_1997 YTRSPIKAHDYATGLFSAFGGAVEYLGRMRGLPAQTLTVNRRLSGLSLNS
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu DPKWKGFPTLESPDLYREFWSILLSKVGERTLAEWQQRFDENPDLCAEIF
MAB_2765|M.abscessus_ATCC_1997 LQLTFSNGRALGFDDYTTGPDNGIYRTRDNRFFGMIGLHPKLRDGITEYL
MMAR_0311|M.marinum_M --------------------------------------------------
MUL_4811|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4465|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1895|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2023|M.smegmatis_MC2_155 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1892|M.avium_104 --------------------------------------------------
TH_4358|M.thermoresistible__bu RSGHEVFDHPQLLHEGRSTIVEDPEVGPVRQPSTLVHTKGGPLGQPLPAP
MAB_2765|M.abscessus_ATCC_1997 G--ATSREGLRRAISQRDAQDLEDSFAQRRLPGGIVRTPQEWLDHPQGRA
MMAR_0311|M.marinum_M ------MSNCGSDCDSSLGAGAGKRTGPLSGVRVVDLTAMVMGPYCTQIM
MUL_4811|M.ulcerans_Agy99 -----------------MGAGAGNRTGPLSGVRVVDLTAMVMGPYCTQIM
Mflv_4465|M.gilvum_PYR-GCK --------------MTT---------GPLDGIRVIEVGTLISGPFAGRLL
Mvan_1895|M.vanbaalenii_PYR-1 --------------MTT---------GPLDGIRVIEVGTLISGPFAGRLL
MSMEG_2023|M.smegmatis_MC2_155 --------------MTDNAIRDTPDIRPLAGVRVLELGNYIAAPTAGRML
Mb3300|M.bovis_AF2122/97 -------------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVL
Rv3272|M.tuberculosis_H37Rv -------------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVL
MAV_1892|M.avium_104 -------------------------MGPLSGVTVVSLEQAVAAPYATRQL
TH_4358|M.thermoresistible__bu RLGDASGGWLQNPPVADFSENREMTTPPLSGITILEFGEMFAAPYASSVL
MAB_2765|M.abscessus_ATCC_1997 CAEHPMVLVDQLSKGGSHRRLGNATVRPLEGVRVVELANVVAGPTTGRAL
** *. ::.. . .* :
MMAR_0311|M.marinum_M ADMGADVIKIEPPQG-DDTRYVSVGPAAGMSGVFVNVN-RGKRSAVIDLK
MUL_4811|M.ulcerans_Agy99 ADMGADVIKIEPPQG-DDTRYVSVGPAAGMSGVFVNVN-RGKRSAVIDLK
Mflv_4465|M.gilvum_PYR-GCK GDMGAEVIKVEPPGA-PDPLRTWGQAELDGHHFFWTVHARNKKAVTLNLR
Mvan_1895|M.vanbaalenii_PYR-1 GDMGAEVIKIEPPGA-PDPLRTWGQAELDGHHFFWTVHARNKKAVTLNLR
MSMEG_2023|M.smegmatis_MC2_155 ADFGAEVIKVERPGT-GDELRNWRLYAGSTSMLYRTIN-RNKKSIVLDLK
Mb3300|M.bovis_AF2122/97 VDLGAEVIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLT
Rv3272|M.tuberculosis_H37Rv VDLGAEVIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLT
MAV_1892|M.avium_104 ADLGARVIKVERPDG-GDFARGYDHSVHGDSSYFVWLN-RGKESLTLDLK
TH_4358|M.thermoresistible__bu ADLGARVIKFENIKG--DNIRSLLQFPEAAG----AKVMQGKESIQVDLH
MAB_2765|M.abscessus_ATCC_1997 AEQGAEVIKLACVGG-------------PVTIGIWLDANWGKRQFRMNIK
: ** ***. .*. :::
MMAR_0311|M.marinum_M SDSGQAAVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCY
MUL_4811|M.ulcerans_Agy99 SDSGQAAVRALIEGADVFIHSMRAKAIARLGLSYPEVAAINPAIVYTNCY
Mflv_4465|M.gilvum_PYR-GCK VPEGRDLFLDLVERSDVIVENFRPGTLEKWNLGYDVLRERNRGIILVRVS
Mvan_1895|M.vanbaalenii_PYR-1 VPEGRELFLDLVERSDVIVENFRPGTLEKWGLGYDVLRERNRGIILVRVS
MSMEG_2023|M.smegmatis_MC2_155 SEAGRAVVLDLLRHCDVLLENFRPGTLEKWGLGPERLDEVNPDLVITRIS
Mb3300|M.bovis_AF2122/97 TEQAKQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLT
Rv3272|M.tuberculosis_H37Rv TEQAKQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLT
MAV_1892|M.avium_104 TLEGQRILRQLLANSDVLVQNLGPGATTRLSLDATTLTPEYPRLIVCDIT
TH_4358|M.thermoresistible__bu TDEGRAVAHRLVASADVVLQSMRAGVADRLGIGVEALRAINPDVIYVSAG
MAB_2765|M.abscessus_ATCC_1997 GPAGQAKLRELLAGADVLLNSMSPGRLTELGLGPEALQQINPNLILADFS
.: * .**.:. : . . .:. : ::
MMAR_0311|M.marinum_M GYGRRGPNRDLPAYDDTIQAACGLPSVQEQLTGEPS--------------
MUL_4811|M.ulcerans_Agy99 GYGRRGPNRDLPAYDDTIQAACGLPSVQEQLTGEPS--------------
Mflv_4465|M.gilvum_PYR-GCK GYGQTGPDAHKAGYASVAEAASGLRHMNGFPGGPPP--------------
Mvan_1895|M.vanbaalenii_PYR-1 GYGQTGPDAHKAGYASVAEAASGLRHMNGFPGGPPP--------------
MSMEG_2023|M.smegmatis_MC2_155 AFGQTGPMSERPGFAAVAEAYGGLRELVGDPDRPPV--------------
Mb3300|M.bovis_AF2122/97 AYGGNGPHGSRPGIDLVVAAEAGMTTGMPTPEGKPQ--------------
Rv3272|M.tuberculosis_H37Rv AYGGNGPHGSRPGIDLVVAAEAGMTTGMPTPEGKPQ--------------
MAV_1892|M.avium_104 GYGGTGPWRDRKAYDLLVQAEAGLLSVTGS-GDEVA--------------
TH_4358|M.thermoresistible__bu GYGVDGPYAARPAYAPSISAAGGVALTNTPDAEYATSSLDEVMQHVPRIT
MAB_2765|M.abscessus_ATCC_1997 FAPKNSPWFDRKGFEQIAQSVSGIVSVNSQDRYVDDP-------------
.* . : *:
MMAR_0311|M.marinum_M ---YVGTIMADKVAGLTALYATMMALFHR-------ERTGQGQEVEIGMF
MUL_4811|M.ulcerans_Agy99 ---YVGTIMADKVAGLTALYATMMALFHR-------ERTGQGQEVEIGMF
Mflv_4465|M.gilvum_PYR-GCK ---RLALSLGDSLAGMFAAQGALAALYRR-------SVTGEGQIVDAALT
Mvan_1895|M.vanbaalenii_PYR-1 ---RLALSLGDSLAGMFAAQGALAALYRR-------SVTGDGQVVDAALT
MSMEG_2023|M.smegmatis_MC2_155 ---RTGVSIGDSIAGIHAAFGTVMALFQRERAKAPTEIPLPQRIIDVALN
Mb3300|M.bovis_AF2122/97 ---IIPFQLVDNASGHVLAQAVLAALLHR-------ERNGVADVVQVAMY
Rv3272|M.tuberculosis_H37Rv ---IIPFQLVDNASGHVLAQAVLAALLHR-------ERNGVADVVQVAMY
MAV_1892|M.avium_104 ---RTGVSIADIAAGMFAFSGILTALYVR-------ATTGDVRPVSVSLF
TH_4358|M.thermoresistible__bu TAGTSAELQSDGLAALTVASAILAALVGR-------DRGRPLYDVRTSML
MAB_2765|M.abscessus_ATCC_1997 --THISVLINDFCSAYNLATGIVSALAAR-------EEQGGFWYVEHSLL
* :. . : ** * : .:
MMAR_0311|M.marinum_M EAVASFMLVEHANGAMFDPPLGPAVYPRTVAP----------NRRPYRTS
MUL_4811|M.ulcerans_Agy99 EAVASFMLVEHANGAMFDPPLGPAVYPRTVAP----------NRRPYRTS
Mflv_4465|M.gilvum_PYR-GCK ESCLAVQESTIPDYDVGGVVRGPSGTRLEGIA----------PSNIYPTA
Mvan_1895|M.vanbaalenii_PYR-1 ESCLAVQESTIPDYDVGGVVRGPSGTRLEGIA----------PSNIYPTA
MSMEG_2023|M.smegmatis_MC2_155 ESILSVMESLIPDYLAYGVQRQRVGGRMEGIA----------PSNAYPCA
Mb3300|M.bovis_AF2122/97 DVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTA
Rv3272|M.tuberculosis_H37Rv DVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTA
MAV_1892|M.avium_104 ESLVELVSQPAYYAHYGGTAPPRTGARHATIA----------PYGPFTAG
TH_4358|M.thermoresistible__bu ATVTHVVSDWLVDYADAPAAAVPVHDGNGLSA----------LYRIYGAS
MAB_2765|M.abscessus_ATCC_1997 RNATEAVRYVRPMNDERYAPVSIADLRR----------------------
MMAR_0311|M.marinum_M DGYLAALIYN-DKHWAAFV-DAVRPP--WASEQYATLEGRARQIDTVYAL
MUL_4811|M.ulcerans_Agy99 DGYLAALIYN-DKHWAAFV-DAVRPP--WASEQYATLEGRARQIDTVYAL
Mflv_4465|M.gilvum_PYR-GCK DGSWVVIAANQDTVFRRLC-AAMGQPELATDERFADHVARGRNQDEIDKI
Mvan_1895|M.vanbaalenii_PYR-1 DGSWVVIAANQDTVFRRLC-AAMGQPELATDERFANHVARGRNQDELDKI
MSMEG_2023|M.smegmatis_MC2_155 DGTSIIVAGNGDAIYQRYM-RTIGRPDLATDPDLQTNAGRWARRDELDEA
Mb3300|M.bovis_AF2122/97 DG-YIVISAYVPKHWQKLC-YLIGRPDLVEDQRFAEQRSRSINYAELTAE
Rv3272|M.tuberculosis_H37Rv DG-YIVISAYVPKHWQKLC-YLIGRPDLVEDQRFAEQRSRSINYAELTAE
MAV_1892|M.avium_104 DGGTVLLAVQNQREWRRLCDEVLATPGLCEDPRFVTNPDRVTHRDELEAI
TH_4358|M.thermoresistible__bu EG-RIFLAAPQPKEWPALV-DALRDFTDLDEERFATPDARAANDDALSAR
MAB_2765|M.abscessus_ATCC_1997 ---WAIDQDTPNGVFTRLT----------PPVTFSHTPSKAWRPTGLPFG
: : . :
MMAR_0311|M.marinum_M LAETFAARTTQEWLDLLEELEIPASALSS---PAELFDNQHLNAVGFFET
MUL_4811|M.ulcerans_Agy99 LAETFAARTTQEWLDLLEELEIPASALSS---PAELFDNQHLNAVGFFET
Mflv_4465|M.gilvum_PYR-GCK IGGWAAQRQPDEIISTLSEAGVISGPINT---VAEVVEDPQLQARGMIAD
Mvan_1895|M.vanbaalenii_PYR-1 IGAWAAERQPADIIATLSEAGVISGPINT---VAEVVKDPQLQARGMIAD
MSMEG_2023|M.smegmatis_MC2_155 ISAWTIRHTRDEALKLLDEAGVPSGPIYT---AADICDDQQYEARNMIQH
Mb3300|M.bovis_AF2122/97 LELALASKTATEWVQLLQANGLMACLAHT---WKQVVDTPLFAESDLTLE
Rv3272|M.tuberculosis_H37Rv LELALASKTATEWVQLLQANGLMACLAHT---WKQVVDTPLFAENDLTLE
MAV_1892|M.avium_104 IHAAIASMTADELAHRLEAAGIANARMND---VETLWSHPVLAGRDRWRE
TH_4358|M.thermoresistible__bu LEAVFSKEPAAFWEKRFGAAGVGCVELYEGAPARLIQTDPQLAAEYAVSA
MAB_2765|M.abscessus_ATCC_1997 GVEGLSWQD-----KPIGSDDPLATPHYP----------SRIVAEGRLHD
:
MMAR_0311|M.marinum_M IDTAHGPVR-----FPGVPTWFSRTPG--RVSGPAPQLGADTSAVLEELG
MUL_4811|M.ulcerans_Agy99 IDTAHGPVR-----FPGVPTWFSRTPG--RVLGPAPQLGADTSAVLEELG
Mflv_4465|M.gilvum_PYR-GCK HWDERIGRN---VKGPGVVPVLSETPGTIRSAGSARPGQHNDEIYRDLLG
Mvan_1895|M.vanbaalenii_PYR-1 HWDERIGRN---VKGPGVVPVLSETPGTIRSAGSSRPGEHNDEIYRGLLG
MSMEG_2023|M.smegmatis_MC2_155 FAVDTGGAEPQPVGFPGIVPVIGGASLPIRNVG-PDLGEHTHEVLSGILG
Mb3300|M.bovis_AF2122/97 VGRGADTIT-------VIRTPARYASFRAVVTDPPPTAGEHNAVFLARP-
Rv3272|M.tuberculosis_H37Rv VGRGADTIT-------VIRTPARYASFRAVVTDPPPTAGEHNAVFLARP-
MAV_1892|M.avium_104 VRAPGGAIE-------ALLPPATLRDVEPQLGDVPGLAAHSRMILRELGY
TH_4358|M.thermoresistible__bu VSPIFDEHLR-------LAPLVGLSRSKTTARAGCLAGQHTSAVLREFGY
MAB_2765|M.abscessus_ATCC_1997 FVECYGIED------------RGDGGGDVSFFSPGLAVLSRNQGLEAI--
MMAR_0311|M.marinum_M INAADAQPAGPA--------
MUL_4811|M.ulcerans_Agy99 INAADAQPAGPA--------
Mflv_4465|M.gilvum_PYR-GCK RSAAELDKLQEEGVL-----
Mvan_1895|M.vanbaalenii_PYR-1 KTDAELERLRAGGVL-----
MSMEG_2023|M.smegmatis_MC2_155 LTDAEIEALS----------
Mb3300|M.bovis_AF2122/97 --------------------
Rv3272|M.tuberculosis_H37Rv --------------------
MAV_1892|M.avium_104 TNEAIADLVRSGVTTVASDH
TH_4358|M.thermoresistible__bu DDATIAEWQDAGVINCG---
MAB_2765|M.abscessus_ATCC_1997 --------------------