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VMHSGADIPSLYEWLSPALGPVSPAAVAPCTGPRHWWGGQLDVEGLALGSVQAALTAANIACTGERLSTD SRAVAAAFASLDHLRVDGRQPVGFAELSGFFRAADGWVRLHANYPHHARVLVETFGVDSKDALAEQILRL GADLIAERITASGGLAVALRSPNQWRGGGAGKFVDTQPWIRFELGETLGAPLAPGRRLSGVRVLDLTRVI AGPVATRFLALLGADVLRVDPPSNPELVDQYLDTGFGKRSAISDFADAAQRDRIEALLAEADVVISGYRP AALTRYGLDSAALRERFPALSVVTLDAWGDGGPWGDRRGFDSLVQSAIGVGELYGQTDSTGAWRPGALPV QALDHATGYGVAAAALALLARRSQIGAGSAHLCLARTGHLLLDLARRNGGRQEFTVARESVESSFGTLSF AQPVAFSGGVRLTYRFPPGPYGNDPLSWAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1889 | - | - | 100% (450) | L-carnitine dehydratase |
| M. abscessus ATCC 19977 | MAB_2765 | - | 6e-23 | 28.18% (291) | putative L-carnitine dehydratase |
| M. abscessus ATCC 19977 | MAB_4651c | - | 2e-17 | 29.53% (193) | putative L-carnitine dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 7e-23 | 34.18% (196) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_5186 | - | 2e-20 | 31.77% (192) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 7e-23 | 34.18% (196) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1267 | - | 1e-24 | 35.71% (196) | acyl-CoA transferase |
| M. avium 104 | MAV_4237 | - | 6e-26 | 36.73% (196) | YfdE protein |
| M. smegmatis MC2 155 | MSMEG_6773 | - | 3e-21 | 33.85% (192) | CaiB/BaiF family protein |
| M. thermoresistible (build 8) | TH_4300 | - | 2e-26 | 36.61% (183) | PUTATIVE putative caib/baif family protein |
| M. ulcerans Agy99 | MUL_2621 | - | 7e-25 | 35.71% (196) | acyl-CoA transferase |
| M. vanbaalenii PYR-1 | Mvan_4314 | - | 6e-20 | 31.11% (225) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu MSSSAGTQAAPQSVTPLAGTRVVDLSTTLPGVVCTQFLAD-------SGA
Mvan_4314|M.vanbaalenii_PYR-1 --MSSPAADGSAYDPPLAGVQILDLSSGPMTAVGRLFADLGAHVTALHLR
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu DVLMVEPPGGSPVRSLRGWPAFGRGKRSTVVDLKSGSGADELDALLRDAD
Mvan_4314|M.vanbaalenii_PYR-1 GVTGDEPVGPHVDSVAVGSAINRHGMDTVEIDPGTPTGRQRFAELVAGAD
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu VVVTTFSPAALAELGIDSEALLARHPRLVIAHITGWGRSGPWRDLKGYEG
Mvan_4314|M.vanbaalenii_PYR-1 ILIENTRPGSPAETALSIREIRDQHPALVILSISDFGRDTDYRNWQASG-
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu LVLAKAGLSHAVRRMANPPRPSYVTVPYASFAAGHIAVHGILAALHERDR
Mvan_4314|M.vanbaalenii_PYR-1 -PVFHALTSELSRSGIPGREPLIPPADLPYQVAAAQAAVMTLSLFLDRLR
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu SGLGQIVDADLVRGVHSIDAWNWFGEMVGIRWPDAYENVEAWTEEGTPQS
Mvan_4314|M.vanbaalenii_PYR-1 TGEGDLIDFSVLDGAMQTLDPPFGTAGSASAGVAVSAQQRDWNAE-----
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu PMLLALLAAPTKDGHWLQFAQVSPHLFAAMLTEFGMMELLADPKWKGFPA
Mvan_4314|M.vanbaalenii_PYR-1 ---RQRYPIIPCKDGHVRICILSRRQWHGMFALMGSPEEFADPSYDKLG-
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu LESPVLYKEFWSIMLAKVGERTLAEWQQVFDNNPDLCAELFRSGPQVLDH
Mvan_4314|M.vanbaalenii_PYR-1 --KRFRSPHLLEAIERFCADKTRAELEAAGQAHGVPTAALLTLAEALN--
MAB_1889|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1267|M.marinum_M --------------------------------------------------
MUL_2621|M.ulcerans_Agy99 --------------------------------------------------
MAV_4237|M.avium_104 --------------------------------------------------
MSMEG_6773|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5186|M.gilvum_PYR-GCK --------------------------------------------------
TH_4300|M.thermoresistible__bu PQLVHDRRSTVVEDPEVGPVRQPSTLIHTADGPLRQPSPAPRLGEAGAGW
Mvan_4314|M.vanbaalenii_PYR-1 ADHFTARGFFRDVELAPGVVAPVPVGVSEVDGHRASALQSAARSSEIDRL
MAB_1889|M.abscessus_ATCC_1997 -------------MMHSGADIPSLYEWLSPALGPVSPAAVAPCTGPRHWW
Mb3300|M.bovis_AF2122/97 --------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVE
Rv3272|M.tuberculosis_H37Rv --------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVE
MMAR_1267|M.marinum_M --------MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVE
MUL_2621|M.ulcerans_Agy99 --------MPEGNPAKPLDGFRVLDFTQNVAGPLAGQVLADLGAEVIKVE
MAV_4237|M.avium_104 ----MPHETPNGKPPKPLDGFRVLDFTQNIAGPMAGQVLADLGAEVIKIE
MSMEG_6773|M.smegmatis_MC2_155 -----------------MRGLRVLDFTHVVAGPLCTMTLADLGADVVKIE
Mflv_5186|M.gilvum_PYR-GCK -----------MPSAGPLSGVKVVDLTAVVAGPYCTQIMADMGADVVKVE
TH_4300|M.thermoresistible__bu RSEGVAMAGGDASSQPPLAGITIVEFGEMFAAPYATSVLADLGARVIKFE
Mvan_4314|M.vanbaalenii_PYR-1 DTAPLLANRRRAGQGLPLEGIRVLDLGVIVVGADTARLFGDLGADVVKIE
MAB_1889|M.abscessus_ATCC_1997 GGQLDVEGLALGSVQAALTAANIACTGERLSTDSRAVAAAFASLDHLRVD
: . : . . ::.:
Mb3300|M.bovis_AF2122/97 APGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
Rv3272|M.tuberculosis_H37Rv APGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRL
MMAR_1267|M.marinum_M APGGEAARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRL
MUL_2621|M.ulcerans_Agy99 APGGEAARHITAVLPHRPPLATYFLPNNRGKKSVSVDLSTDTARRQILRL
MAV_4237|M.avium_104 APIGEAARHITAVLPGRPPLATLFLPHNRGKKSVLADLRDDEAKQRILRL
MSMEG_6773|M.smegmatis_MC2_155 PPAGEIGRRIG--PPWRDGQSVIWQSVNRNKRSLTLDLKTPAGRRAARRM
Mflv_5186|M.gilvum_PYR-GCK APQGDNARYISVGPEPG--LSGVFTNVNRGKRSVVLDLQTDAGKDALRTL
TH_4300|M.thermoresistible__bu NVNGDNIRNLLQFPEAA--GAKVMQ----GKESIQVDLHTDEGKAVAHRI
Mvan_4314|M.vanbaalenii_PYR-1 HSAHPDGLRVG----KLTSMTQPFAAGHRNKRSIGIDLRSDEGRRLAHRL
MAB_1889|M.abscessus_ATCC_1997 GRQPVGFAELSGFFRAADGWVRLHANYPHHARVLVETFGVDSKDALAEQI
: . : : :
Mb3300|M.bovis_AF2122/97 ADT-ADVVLEAFRPGTMEKLGLGPDD---------LRSRNPNLIYARLTA
Rv3272|M.tuberculosis_H37Rv ADT-ADVVLEAFRPGTMEKLGLGPDD---------LRSRNPNLIYARLTA
MMAR_1267|M.marinum_M ADT-ADVVLEGFRPGVMERMGLGPED---------LRARNPKLIYARLSA
MUL_2621|M.ulcerans_Agy99 ADT-ADVVLEGFRPGVMERMGLGPED---------LRARNPKLIYARLSA
MAV_4237|M.avium_104 VDT-ADVVLEGFRPGVMERMGLGPEE---------LQGRNPRLVYARLSA
MSMEG_6773|M.smegmatis_MC2_155 ARQ-ADVVVESFRPGVMTDLDLGYDT---------LASANPALVYCSISA
Mflv_5186|M.gilvum_PYR-GCK VAR-ADVFIHSMRAAAIAKLGFDYAA---------VADLNPSIVYTNCYG
TH_4300|M.thermoresistible__bu VAS-ADVVLQSMRAGAAERLGIDAAT---------LRAVKPDLIYVSAPG
Mvan_4314|M.vanbaalenii_PYR-1 VEQ-SDVVLTNFKPGVADALGMDYAT---------LRQVNPNIVVVDSSA
MAB_1889|M.abscessus_ATCC_1997 LRLGADLIAERITASGGLAVALRSPNQWRGGGAGKFVDTQPWIRFELGET
:*:. : .. : : . :* :
Mb3300|M.bovis_AF2122/97 YGGNGPHGSRPGIDLVVAAEAGMTTG-----------------MPTPEGK
Rv3272|M.tuberculosis_H37Rv YGGNGPHGSRPGIDLVVAAEAGMTTG-----------------MPTPEGK
MMAR_1267|M.marinum_M FGGNGPHGTRPGVDLMVAAEAGMTTG-----------------MPTPDGK
MUL_2621|M.ulcerans_Agy99 FGGNGPHGTRPGVDLMVAAEAGMTTG-----------------MPTPDGK
MAV_4237|M.avium_104 YGGNGPEGSRPGVDLMVAAESGMTTG-----------------MPTPTGK
MSMEG_6773|M.smegmatis_MC2_155 FGQAGPASDRPGVDGIMQAVTGLMST-----------------LGEPESG
Mflv_5186|M.gilvum_PYR-GCK YGRTGPYAARPAYDDTIQAECGLAAV-----------------QEELTGT
TH_4300|M.thermoresistible__bu YGVDGPYGARPSYAPSIGAAGGVALTNTPDAACATSCLDEVMHQAPRVTS
Mvan_4314|M.vanbaalenii_PYR-1 FGPTGPWAKRLGYGPLVRAAVGFTDL---------------WVYPGEAET
MAB_1889|M.abscessus_ATCC_1997 LGAPLAPGRRLSGVRVLDLTRVIAGP-----------------VATRFLA
* . . * . : .
Mb3300|M.bovis_AF2122/97 PQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQA
Rv3272|M.tuberculosis_H37Rv PQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQA
MMAR_1267|M.marinum_M PQIIPFQLVDNASGHVLAQAVLAALLNRERHGVADTVRVAMYDVAVGLQA
MUL_2621|M.ulcerans_Agy99 PQIIPFQLVDNASGHVLAQAVLAALLNRERHGVADTVRVAMYDVAVGLQA
MAV_4237|M.avium_104 PQIIPFQLVDAASGHVLAQAVLAALLNRERHGVADVVRVAMYDVAVSLQA
MSMEG_6773|M.smegmatis_MC2_155 PAKVQVPAADMVTGYLASIAVLAALHEVRDGGRGQHLDVSLYNATILLQQ
Mflv_5186|M.gilvum_PYR-GCK AGYVGSIMADKICGLTAVNATMMALFHRERTGEGQEVEVPMFETMAAFML
TH_4300|M.thermoresistible__bu AGTAPELQSDGLAALAVASAILTALIGRDRGNPVNDVRTSMLGTVTHVLT
Mvan_4314|M.vanbaalenii_PYR-1 YCDTVTVYPDHVAARIGALAAMALLLRRERTGAGGSASISQAEVMLSHLA
MAB_1889|M.abscessus_ATCC_1997 LLGADVLRVDPPSNPELVDQYLDTGFGK-RSAISDFADAAQRDRIEALLA
* : .
Mb3300|M.bovis_AF2122/97 NQLMMHLNRAASDQ-PKPEPAPKAKRRKGVGFATQPSDAFRTADG--YIV
Rv3272|M.tuberculosis_H37Rv NQLMMHLNRAASDQ-PKPEPAPKAKRRKGVGFATQPSDAFRTADG--YIV
MMAR_1267|M.marinum_M NQLTMHLNRPSSDAPKRPEQTPAGARRKRVAFATQPSDAFRAADG--YLL
MUL_2621|M.ulcerans_Agy99 NQLTMHLNRPSSDAPKRPEQTPAGARRKRVAFATQPSDAFRAADG--YLL
MAV_4237|M.avium_104 SQLTIHLNKPNADH-KPSDSASKPKRRKGVGFATQPSDAFKAADG--YLV
MSMEG_6773|M.smegmatis_MC2_155 IGFTSYLASG-----------AEPQRLGSAAPYAAPNEALPTADG--WIM
Mflv_5186|M.gilvum_PYR-GCK VEHANGAMFD-----------PPLGPALYPRTVARNRRPYQTSDG--HIA
TH_4300|M.thermoresistible__bu DWLVDYPDAP-----------TAPAPVHDGNGLSALYRIYAAGDG--HIF
Mvan_4314|M.vanbaalenii_PYR-1 ADIAADALLR------------SGHTHTGASRPDAPWGLFPAQGDDRWVA
MAB_1889|M.abscessus_ATCC_1997 EADVVISGYR------------PAALTRYGLDSAALRERFPALSVVTLDA
: .
Mb3300|M.bovis_AF2122/97 ISAYVPKHWQKLCYLIGRPDLVEDQRFAEQRSRSINYAELTAELELALAS
Rv3272|M.tuberculosis_H37Rv ISAYVPKHWQKLCYLIGRPDLVEDQRFAEQRSRSINYAELTAELELALAS
MMAR_1267|M.marinum_M ISAYVPKHWQRLCEIIGRPDLLDDERFIDQRARAINYAELTEELESALAA
MUL_2621|M.ulcerans_Agy99 ISAYVPKHWQRLCEIIGQPDLLDDERFIDQRARAINYAELTEELESALAA
MAV_4237|M.avium_104 ISAYVPKHWDKLCEVIGRPDLRDDERFADQRSRALNYPELTEELEKALAA
MSMEG_6773|M.smegmatis_MC2_155 IAAYDPARWNALCDALGAPDLSSDARFATNDDRVRNRPALRTELGRLLRA
Mflv_5186|M.gilvum_PYR-GCK ALIYNDKQWQAFIDAVK--PAWATDRYATMAGRAADIDTVYGLIGDALRE
TH_4300|M.thermoresistible__bu LAAPQPKEWQPLVDALRDFADLADDRFATPEGRAANDDELARRLEAVFGK
Mvan_4314|M.vanbaalenii_PYR-1 ITVRDDADRRALGEVVGFTGADRQLFDDAVRAWTTQRSHLEAMEQLQAAG
MAB_1889|M.abscessus_ATCC_1997 WGDGGPWGDRRGFDSLVQSAIGVGELYGQTDSTGAWRPGALPVQALDHAT
:
Mb3300|M.bovis_AF2122/97 KTATEWVQLLQANGLMACLAHT---WKQVVDTPLFAESDLTLEVG-----
Rv3272|M.tuberculosis_H37Rv KTATEWVQLLQANGLMACLAHT---WKQVVDTPLFAENDLTLEVG-----
MMAR_1267|M.marinum_M KTAAQWVELLHEGGLMACLAYT---WKQVVTTPLFAENELALQVG-----
MUL_2621|M.ulcerans_Agy99 KTAAQWVELLHEGGLMACLAYT---WKQVVTTPLFAENELALQVD-----
MAV_4237|M.avium_104 KTADEWVRLLQAAGLMACHAYT---WKQVVGTPLFAENELALQVG-----
MSMEG_6773|M.smegmatis_MC2_155 RTTQVWLDVLSARDILCAPVNG---YGQVVASPEYAASGLHRPIGPIDTP
Mflv_5186|M.gilvum_PYR-GCK RTTAEWLALFDELGIPASPLRS---TGDLFTDPHLDAVGFFETVQ-----
TH_4300|M.thermoresistible__bu EPAAFWEKRLSAAGIGCVELYEGAPARLIQTDPALAAEYTVPAVS-----
Mvan_4314|M.vanbaalenii_PYR-1 VPAGAVLHADEIPGWGYYEQRR---AFREELHPYGSAPFMMENVQIHCD-
MAB_1889|M.abscessus_ATCC_1997 GYGVAAAALALLARRSQIGAGS---AHLCLARTGHLLLDLARRNGG----
.
Mb3300|M.bovis_AF2122/97 --------RGADTITVIRTPARYASFRAVVT----DPPPTAGEHNAVFLA
Rv3272|M.tuberculosis_H37Rv --------RGADTITVIRTPARYASFRAVVT----DPPPTAGEHNAVFLA
MMAR_1267|M.marinum_M --------SGDDAVTVIRTPARYSSFSAVLA----EPPAATGEHNETLLG
MUL_2621|M.ulcerans_Agy99 --------SGDDAVTVIRTPARYSSFSAVLA----DPPPATGEHNETLLG
MAV_4237|M.avium_104 --------EGADAVTVIRTPARYSSFEAASAGWATDPPPALGQHTEEYLG
MSMEG_6773|M.smegmatis_MC2_155 GLVLGPSQPAAPPDTAPPAPGQHSAEVLAEYGLSEDEVAALIEHGVVNDV
Mflv_5186|M.gilvum_PYR-GCK --------TGHGPVRFPGVPTGFSRTPGRVRGG----APRLGEHTAEVLA
TH_4300|M.thermoresistible__bu --------PVFDEHLRFSPLAGLSRSATRAPG-----GCLAGQHTAAVLR
Mvan_4314|M.vanbaalenii_PYR-1 --------HVADPPLGQAPLLGEQTVEIAAELLGLDPAQIDDLHRRGVLE
MAB_1889|M.abscessus_ATCC_1997 --------RQEFTVARESVESSFGTLSFAQPVAFSGGVRLTYRFPPGPYG
.
Mb3300|M.bovis_AF2122/97 RP-------------------
Rv3272|M.tuberculosis_H37Rv RP-------------------
MMAR_1267|M.marinum_M ES-------------------
MUL_2621|M.ulcerans_Agy99 ES-------------------
MAV_4237|M.avium_104 APQTAS---------------
MSMEG_6773|M.smegmatis_MC2_155 APSRAAS--------------
Mflv_5186|M.gilvum_PYR-GCK DWGQEPVK-------------
TH_4300|M.thermoresistible__bu EFGYDDATIAKWQDAGVINCG
Mvan_4314|M.vanbaalenii_PYR-1 TPEVETATQS-----------
MAB_1889|M.abscessus_ATCC_1997 NDPLSWAP-------------