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VNSAPDTLTRGLSARHIRFIALGSAIGTGLFYGSAEAIRQAGPSVLVAYLLGGAVIYIVLRSLGEMAVRR PVAGSFGEYATQYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFPGVPRWVWVFSIIFFIGAINL LSVKVFGEVEFWLSLVKVLAIVAMIAGGIAILVWGSSTGREEQRGIANLWNDGGFFPHGLAGFVGSFMIV MFAFGGTEIIGITAGEAKDPARTIPRAVNTVPVRIILFYVLTLAVIMALYPWRSIDSNSSPFVQIFEGLG FTSAATVLNLVVVTAALSAINSDIFAAGRMIYGMAQRGQAPAVMRRVSRNGVPWMTVVVMTVALLVGVVL NYAIEERVFVIIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPVPGWPYLQVFATGFLMFVVLL LGFGADTRVALIVGAAWLLVLVGAFAMSRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2535 | - | - | 100% (451) | amino acid transporter |
| M. abscessus ATCC 19977 | MAB_3866c | - | e-115 | 44.34% (442) | putative amino acid permease |
| M. abscessus ATCC 19977 | MAB_1132c | - | 8e-81 | 35.16% (438) | L-asparagine ABC transporter permease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1730c | cycA | 1e-94 | 40.13% (446) | D-serine/alanine/glycine transporter protein CycA |
| M. gilvum PYR-GCK | Mflv_1998 | - | 8e-66 | 33.33% (450) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv1704c | cycA | 7e-94 | 39.91% (446) | D-serine/alanine/glycine transporter protein CycA |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 1e-77 | 34.42% (459) | putative L-asparagine permease |
| M. marinum M | MMAR_1093 | cycA | 6e-97 | 39.73% (448) | D-serine/D-alanine/glycine transporter, CycA |
| M. avium 104 | MAV_4626 | - | 1e-72 | 34.46% (444) | gaba permease |
| M. smegmatis MC2 155 | MSMEG_3587 | - | 5e-97 | 40.76% (449) | D-serine/D-alanine/glycine transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 1e-19 | 21.70% (447) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_0851 | cycA | 7e-94 | 38.94% (452) | D-serine/D-alanine/glycine transporter, CycA |
| M. vanbaalenii PYR-1 | Mvan_0718 | - | 4e-22 | 25.27% (376) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1730c|M.bovis_AF2122/97 ---------MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFM
Rv1704c|M.tuberculosis_H37Rv ---------MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFM
MMAR_1093|M.marinum_M ---------MPEDVATCQPTESTPHLHRGLSNRHIQLIAIGGAIGTGLFM
MUL_0851|M.ulcerans_Agy99 --------MMPEDVATCQHTESTPHLHRGLSNRHIQLIAIGGAIGTGLFM
MSMEG_3587|M.smegmatis_MC2_155 --------------MSEQTLPEAEHLSRQLSNRHIQLIAIGGAIGTGLFM
MAB_2535|M.abscessus_ATCC_1997 ------------------MNSAPDTLTRGLSARHIRFIALGSAIGTGLFY
Mflv_1998|M.gilvum_PYR-GCK -------------------MSAAPTLKKALNQRQLTMIAIGGVIGAGLFV
MAV_4626|M.avium_104 -------------------MAGTSQLRQGLSQRQLSMIALGGVIGAGLFV
MLBr_01305|M.leprae_Br4923 MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAIGTGLFL
Mvan_0718|M.vanbaalenii_PYR-1 -----------------MSSPGGSTLDRRLGVFDTVTIGLGSMIGAGIFV
TH_0471|M.thermoresistible__bu --MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVIGAGIFT
: * . :.:. **:*:*
Mb1730c|M.bovis_AF2122/97 GSGRTIS-LAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKSFVDFAA
Rv1704c|M.tuberculosis_H37Rv GSGRTIS-LAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKSFVDFAA
MMAR_1093|M.marinum_M GSGRTIS-LAGPAVIVVYAVIGFFVFFVLRAMGELLLSNLNYKSFVDCAA
MUL_0851|M.ulcerans_Agy99 GSGRTIS-LAGPAVIVVYAVIGFFVFFVLRAMGELLLSNLNYKSFVDCAA
MSMEG_3587|M.smegmatis_MC2_155 GSGKTVS-LAGPSVIFVYMIIGFMLFFVMRAMGELLLSNLEYKSFADFAA
MAB_2535|M.abscessus_ATCC_1997 GSAEAIR-QAGPSVLVAYLLGGAVIYIVLRSLGEMAVRRPVAGSFGEYAT
Mflv_1998|M.gilvum_PYR-GCK GSGVVIA-DTGPGAFLTYGMAGVLIIMVMRMLAEMAVANPSTGSFADYSR
MAV_4626|M.avium_104 GSGVVIK-DTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGSFADYAA
MLBr_01305|M.leprae_Br4923 GAGGRLA-KAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGSFVSYAR
Mvan_0718|M.vanbaalenii_PYR-1 ALAPAAA-AAGSGLLIGLAVAAVVAVCNAMSSARLAARYPQSGGTYVYGR
TH_0471|M.thermoresistible__bu VTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGSAYTFSY
. :*.. . : . ..: . .
Mb1730c|M.bovis_AF2122/97 DLLGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFWWP---------GL
Rv1704c|M.tuberculosis_H37Rv DLRGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFWWP---------GL
MMAR_1093|M.marinum_M DLLGPAAGYFMGWSYWFAWIVAGIADLVAITGYSKFWWP---------DV
MUL_0851|M.ulcerans_Agy99 DLLGPAAGYFMGWSYWFAWIVAGIADLVAITGYSKFWWP---------DV
MSMEG_3587|M.smegmatis_MC2_155 DLLGPWAGFFTGWTYWFCWIVTGVAEVVAIAGYVAFWWP---------DL
MAB_2535|M.abscessus_ATCC_1997 QYLGPLAGFLTGWTYALEMVVVCLADVTAFGVYMGFWFP---------GV
Mflv_1998|M.gilvum_PYR-GCK NALGHWAGFSVGWLYWYFWVIVVGFEAIAGAKIVQYW---M-------DV
MAV_4626|M.avium_104 AALGRWAGFSVAWLYWYFWVIVVGFEAVAGGKVLNYW---F-------HA
MLBr_01305|M.leprae_Br4923 EFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFT-------AL
Mvan_0718|M.vanbaalenii_PYR-1 ERLGPFWGHAAGWSFIVGKTASCAAMALTVG------------------F
TH_0471|M.thermoresistible__bu ATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLGEVFEFAGATTRLGPI
* . .*
Mb1730c|M.bovis_AF2122/97 PIWVPALVTVALILAVNLFSVRHFGELEFWFALIKVAAIVCLIAVGAILV
Rv1704c|M.tuberculosis_H37Rv PIWVPALVTVALILAVNLFSVRHFGELEFWFALIKVAAIVCLIAVGAILV
MMAR_1093|M.marinum_M PTWAPALVTIAVMLSINMFGVSKFGETEFWFALIKVAAILCLITVGAILV
MUL_0851|M.ulcerans_Agy99 PTWAPALVTIAVMLSINMFGVSKFGGTEFWFALIKVAAILCLITVGAILV
MSMEG_3587|M.smegmatis_MC2_155 PLWIPALVTVAVLITLNLATVRAFGETEFWFAMIKIVAILALIVVGLVMV
MAB_2535|M.abscessus_ATCC_1997 PRWVWVFSIIFFIGAINLLSVKVFGEVEFWLSLVKVLAIVAMIAGGIAIL
Mflv_1998|M.gilvum_PYR-GCK PLWLSALIFMVLMTATNLFSVASYGEFEFWFAGIKVAAIIAFIAVGAAFV
MAV_4626|M.avium_104 PLWVLSLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLVVGAAYV
MLBr_01305|M.leprae_Br4923 PQWTLALLALAVVLVMNLISVEWFGELEFWAALIKVCALMAFLVVGTIFL
Mvan_0718|M.vanbaalenii_PYR-1 YAWPEYANAVAVASVVALTAVGYAGVQRSAALTRIIVALVLAVLAMVVVV
TH_0471|M.thermoresistible__bu TLDWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVIVGAFFI
: . . . : .:: : :
Mb1730c|M.bovis_AF2122/97 ATN------------FVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIA
Rv1704c|M.tuberculosis_H37Rv ATN------------FVSPHGVHATIENLWNDNGFFPTGFLGVVSGFQIA
MMAR_1093|M.marinum_M ITG------------FTSPDGDRAALANLWNDGGFFPTGFVGLASGFQIA
MUL_0851|M.ulcerans_Agy99 ITG------------FTSPDGDRAALANLWNDGGFFPTGFVGLASGFQIA
MSMEG_3587|M.smegmatis_MC2_155 LSH------------FRAPGGAVASLSNLWDDGGFFPTGPMGFVAGFQIA
MAB_2535|M.abscessus_ATCC_1997 VWG------------SSTGREEQRGIANLWNDGGFFPHGLAGFVGSFMIV
Mflv_1998|M.gilvum_PYR-GCK LG--------------LWPGK-GADFSNLTSHGGFMPLGFGAITVGIVTV
MAV_4626|M.avium_104 IG--------------LVPGH-HDGLTNLVSHGGFFPRGVGAVFAAIVVV
MLBr_01305|M.leprae_Br4923 GGR------------YPVDGH-NTGLSLWTSHGGLFPTGVAPLIVVSSGV
Mvan_0718|M.vanbaalenii_PYR-1 LLG------------FGGADTSRLALGDDVT--------VYGVLQAAGLL
TH_0471|M.thermoresistible__bu KAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLLAGASIV
: .
Mb1730c|M.bovis_AF2122/97 FFAYIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALLAILAVV
Rv1704c|M.tuberculosis_H37Rv FFAYIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALLAILAVV
MMAR_1093|M.marinum_M FFAYIGVELVGAAAAEAADPSHTLPRAINAVPLRVAIFYIGALLAILSVV
MUL_0851|M.ulcerans_Agy99 FFAYIGVELVGAAAAEAADPSHTLPRAINAVPLRVAIFYIGALLAILSVV
MSMEG_3587|M.smegmatis_MC2_155 TFAFVGIELVGTTAAEARDPERNLPRAVNSIPVRVMLFYVAALVIIIAVT
MAB_2535|M.abscessus_ATCC_1997 MFAFGGTEIIGITAGEAKDPARTIPRAVNTVPVRIILFYVLTLAVIMALY
Mflv_1998|M.gilvum_PYR-GCK IFSMVGAEIATIAAAESQDPERAVAKAANSVILRILIFYVGAVLLLVLIV
MAV_4626|M.avium_104 IFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVFLLVAIL
MLBr_01305|M.leprae_Br4923 MFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVILLALLL
Mvan_0718|M.vanbaalenii_PYR-1 FFAFAGYARIATLGEEVRDPARTIPRAVALALVIALMVYAVVAVAVVSEL
TH_0471|M.thermoresistible__bu FFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSLVLTGMV
*: . . * :* : : :. :.: :
Mb1730c|M.bovis_AF2122/97 PWRQFASG--ESPFVTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTG
Rv1704c|M.tuberculosis_H37Rv PWRQFASG--ESPFVTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTG
MMAR_1093|M.marinum_M PWRRFASG--ESPFVTMFALAGLAAAASVVNFVVITSAASSANSGVFSTG
MUL_0851|M.ulcerans_Agy99 PWRRFASG--ESPFVTMFALAGLAAAASVVNFVVITSAASSANSGVFSTG
MSMEG_3587|M.smegmatis_MC2_155 PWREISPD--RSPFVAMFSLAGLGIAASVVNFVVLTSAASSANSGIYSTS
MAB_2535|M.abscessus_ATCC_1997 PWRSIDSN--SSPFVQIFEGLGFTSAATVLNLVVVTAALSAINSDIFAAG
Mflv_1998|M.gilvum_PYR-GCK PWNDESVS--ASPFVAAFNAMGIPYADHVMNAVVLTAVLSCLNSGMYTAS
MAV_4626|M.avium_104 PWDSVELG--ASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNSGLYTAS
MLBr_01305|M.leprae_Br4923 PYSAFKAS--ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNAGLYATG
Mvan_0718|M.vanbaalenii_PYR-1 GVAGLASA--TAPLSDAVRAAGFPGLTPVVNVGAAIAALGALLALLLGVS
TH_0471|M.thermoresistible__bu HYTELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIVLVLGQT
: . *: ::. . . .
Mb1730c|M.bovis_AF2122/97 RMLFGLADEGHAPAAFHQLN-RGGVPAPALLLTAPLLLTSIPLLYAGRSV
Rv1704c|M.tuberculosis_H37Rv RMLFGLADEGHAPAAFHQLN-RGGVPAPALLLTAPLLLTSIPLLYAGRSV
MMAR_1093|M.marinum_M RMLYGLADEGSAPGIFGRLN-RRGVPAPALILTAALLLSAIPLLYAGGSV
MUL_0851|M.ulcerans_Agy99 RMLYGLADEGSAPGIFGRLN-SRGVPAPALILTAALLLSAIPLLYAGGSV
MSMEG_3587|M.smegmatis_MC2_155 RMVYGLSCGGDAPASFGRLT-SRRVPANALFLSGVVLLSSVVMVAAGDSI
MAB_2535|M.abscessus_ATCC_1997 RMIYGMAQRGQAPAVMRRVS-RNGVPWMTVVVMTVALLVGVVLNYAIEER
Mflv_1998|M.gilvum_PYR-GCK RMLFVLAARREAPAALVKVT-NRGVPANAILASSVVGFLCVIAAAVS--P
MAV_4626|M.avium_104 RMLFVLAERGEAPARLVRLS-GRGVPHIAILCSSAVGFLCVVMARVA--P
MLBr_01305|M.leprae_Br4923 RVMHSIAINGSGPKFTARMS-KNGVPYGGILLAAVICLCGVALNAFN--P
Mvan_0718|M.vanbaalenii_PYR-1 RTTLAMARDRYLPAGLAAVHPKHGTPHHAEVAVGLVVAVVAAFVDLRG--
TH_0471|M.thermoresistible__bu RVLFAMSRDGLLPRPLSKTG-PRGTPVRITVLVGALVAIAASVFPVGN--
* :: * .* .
Mb1730c|M.bovis_AF2122/97 IGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQ-RHTDSVYKMPGGVV
Rv1704c|M.tuberculosis_H37Rv IGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQ-RHTDSVYKMPGGVV
MMAR_1093|M.marinum_M IGAFTLITTISSLLFMFVWTMIVISYLVYRRRHAQ-RHADSAYKMPGGVV
MUL_0851|M.ulcerans_Agy99 TGAFTLITTISSLLFMFVWTMIVISYLVYRRRHAQ-RHADSAYKMPGGVV
MSMEG_3587|M.smegmatis_MC2_155 IAAFTLVTTISSLCFMFIWTIILSSYLVYRRRRPQ-QHSASPFKMPGGVV
MAB_2535|M.abscessus_ATCC_1997 V--FVIIASVATFATIFVWLMILLAHFRFRAQQHHGEASVADFPVPGWPY
Mflv_1998|M.gilvum_PYR-GCK DTIFAFLLNSSGAIILFVYLLIAISQIVLRYRTPD---SKLRVKMWLFPV
MAV_4626|M.avium_104 NTVFLFLLNSSGAIILFVYWLIALSQIVLRRRTPA---ERLSVKMWFFPV
MLBr_01305|M.leprae_Br4923 GQAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAGIMRRPRFRMPLAPY
Mvan_0718|M.vanbaalenii_PYR-1 ------AIGFSSFGVLLYYAIANASAWTLG-----------ARLIPAIGL
TH_0471|M.thermoresistible__bu ------LEEMVNIGTLFAFALVSAGVIVLRRTRPD---LKRGFRVPFVPW
: : :
Mb1730c|M.bovis_AF2122/97 MCWAVLVFFAFVIWTLT----TETETATALAWFPLWFVLLAVGWLVTQRR
Rv1704c|M.tuberculosis_H37Rv MCWAVLVFFAFVIWTLT----TETETATALAWFPLWFVLLAVGWLVTQRR
MMAR_1093|M.marinum_M MCWAILGFFVFVIWTLT----TETETATALVWFPLWFVILGIGWALVRRR
MUL_0851|M.ulcerans_Agy99 MCWAILGFFVFVIWTLTTETETETETATALVWFPLWFVILGIGWALVRRR
MSMEG_3587|M.smegmatis_MC2_155 MCWVVLAFFVFLVWAFT----QKSDTLQALLVTPAWFVVLGIAWAFLRRR
MAB_2535|M.abscessus_ATCC_1997 LQVFATGFLMFVVLLLG----FGADTRVALIVGAAWLLVLVGAFAMSRRR
Mflv_1998|M.gilvum_PYR-GCK LSGLTALGILAILVQMFIDTALRSQLVLSLLSWAVVIALFAANKWFVKKR
MAV_4626|M.avium_104 LSVLTLAGITAVLVQMAFDATARSQLWLSLLSWAVVVALY-----FVAR-
MLBr_01305|M.leprae_Br4923 SGYLTLAFLFAVLVVMAFDKPIGTWTVASLIVIVPALIAG----WYSIRK
Mvan_0718|M.vanbaalenii_PYR-1 VGCLVLAFTLPLTSVLAG----AAVVLVGMIAYTIGGTR-----------
TH_0471|M.thermoresistible__bu LPLAAIAACLWLMLNLTG---LTWVRFLGWMALGLVLYFFYGRHHSMLGR
: : .
Mb1730c|M.bovis_AF2122/97 QSRRSFGFHCQVVGVRQQLGRGMARLAMKIHARPKLRSAVVVEPVSAGEP
Rv1704c|M.tuberculosis_H37Rv QSRRSFGFHCQVVGVRQQLGRGMARLAMKIHARPKLRSAVVVEPVSAGEP
MMAR_1093|M.marinum_M P------------GHLEQYHR----FQAEMNG--------TTEGILPPDA
MUL_0851|M.ulcerans_Agy99 P------------GHLEQYHR----FQAEMNG--------TAEGVLPPDA
MSMEG_3587|M.smegmatis_MC2_155 L------------GHKAREAA----FRAALEA----------ESADSAD-
MAB_2535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK PAEGDSGAPTGPPHRVLVLANRTVDSDELLAELSRIGADQTAEYLVVVPA
MAV_4626|M.avium_104 -SRGRVAAR-----------------------------------------
MLBr_01305|M.leprae_Br4923 RVMTIARERMGYTGPFPAIANPPVQPSERSHSQNP---------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0471|M.thermoresistible__bu GMTDISARRTG---------------------------------------
Mb1730c|M.bovis_AF2122/97 GARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR-----
Rv1704c|M.tuberculosis_H37Rv GARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR-----
MMAR_1093|M.marinum_M SART----------------------------------------------
MUL_0851|M.ulcerans_Agy99 SART----------------------------------------------
MSMEG_3587|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK SAVDTGAAATHGPRDVTEATQEAATARLESTLAALRGKNLTVQGELGDYR
MAV_4626|M.avium_104 --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mb1730c|M.bovis_AF2122/97 --------------------------------------------------
Rv1704c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1093|M.marinum_M --------------------------------------------------
MUL_0851|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3587|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1998|M.gilvum_PYR-GCK PLRALDHAVAEFGPDQIVIATLPPEFSMWHRFDVVDRARAQFTVPVTHVV
MAV_4626|M.avium_104 --------------------------------------------------
MLBr_01305|M.leprae_Br4923 --------------------------------------------------
Mvan_0718|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mb1730c|M.bovis_AF2122/97 -----------
Rv1704c|M.tuberculosis_H37Rv -----------
MMAR_1093|M.marinum_M -----------
MUL_0851|M.ulcerans_Agy99 -----------
MSMEG_3587|M.smegmatis_MC2_155 -----------
MAB_2535|M.abscessus_ATCC_1997 -----------
Mflv_1998|M.gilvum_PYR-GCK ATSAVGNQVPR
MAV_4626|M.avium_104 -----------
MLBr_01305|M.leprae_Br4923 -----------
Mvan_0718|M.vanbaalenii_PYR-1 -----------
TH_0471|M.thermoresistible__bu -----------