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PDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAIGTGLFMGSGRTISLAGPAVMVVYGIIGFFVFFVLRA MGELLLSNLNYKSFVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFWWPGLPIWVPALVTV ALILAVNLFSVRHFGELEFWFALIKVAAIVCLIAVGAILVATNFVSPHGVHATIENLWNDNGFFPTGFLG VVSGFQIAFFAYIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALLAILAVVPWRQFASGESPF VTMFSLAGLAAAASVVNFVVVTAAASSANSGFFSTGRMLFGLADEGHAPAAFHQLNRGGVPAPALLLTAP LLLTSIPLLYAGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQRHTDSVYKMPGGVVMCWAVL VFFAFVIWTLTTETETATALAWFPLWFVLLAVGWLVTQRRQSRRSFGFHCQVVGVRQQLGRGMARLAMKI HARPKLRSAVVVEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHDGPDR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1704c | cycA | - | 100% (556) | PROBABLE D-SERINE/ALANINE/GLYCINE TRANSPORTER PROTEIN CYCA |
M. tuberculosis H37Rv | Rv2127 | ansP1 | 7e-86 | 38.63% (453) | L-asparagine permease ansP1 |
M. tuberculosis H37Rv | Rv0346c | ansP2 | 1e-81 | 39.91% (431) | L-asparagine ABC transporter permease |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1730c | cycA | 0.0 | 99.82% (556) | D-serine/alanine/glycine transporter protein CycA |
M. gilvum PYR-GCK | Mflv_1998 | - | 6e-77 | 36.30% (449) | amino acid permease-associated region |
M. leprae Br4923 | MLBr_01305 | ansP2 | 4e-81 | 37.47% (451) | putative L-asparagine permease |
M. abscessus ATCC 19977 | MAB_3866c | - | 4e-99 | 41.43% (449) | putative amino acid permease |
M. marinum M | MMAR_1093 | cycA | 0.0 | 80.04% (461) | D-serine/D-alanine/glycine transporter, CycA |
M. avium 104 | MAV_4626 | - | 4e-75 | 37.03% (451) | gaba permease |
M. smegmatis MC2 155 | MSMEG_3587 | - | 1e-173 | 62.31% (451) | D-serine/D-alanine/glycine transporter |
M. thermoresistible (build 8) | TH_0471 | - | 1e-19 | 22.43% (477) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
M. ulcerans Agy99 | MUL_0851 | cycA | 0.0 | 78.49% (465) | D-serine/D-alanine/glycine transporter, CycA |
M. vanbaalenii PYR-1 | Mvan_1740 | - | 2e-23 | 21.34% (492) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment Rv1704c|M.tuberculosis_H37Rv ---------------MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAI Mb1730c|M.bovis_AF2122/97 ---------------MPDDIAAADPTDTQPHLRRDLANRHIQLIAIGGAI MMAR_1093|M.marinum_M ---------------MPEDVATCQPTESTPHLHRGLSNRHIQLIAIGGAI MUL_0851|M.ulcerans_Agy99 --------------MMPEDVATCQHTESTPHLHRGLSNRHIQLIAIGGAI MSMEG_3587|M.smegmatis_MC2_155 --------------------MSEQTLPEAEHLSRQLSNRHIQLIAIGGAI MAB_3866c|M.abscessus_ATCC_199 -----------------MTVANSESETPDAGYSRGLSARTVQMIAIGGAI MLBr_01305|M.leprae_Br4923 ------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAI Mflv_1998|M.gilvum_PYR-GCK -------------------------MSAAPTLKKALNQRQLTMIAIGGVI MAV_4626|M.avium_104 -------------------------MAGTSQLRQGLSQRQLSMIALGGVI TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVI Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDEPSTRLRKELNWWDLTVFGVSVVI : * : ::.:. .* Rv1704c|M.tuberculosis_H37Rv GTGLFMGSGRTIS-LAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKS Mb1730c|M.bovis_AF2122/97 GTGLFMGSGRTIS-LAGPAVMVVYGIIGFFVFFVLRAMGELLLSNLNYKS MMAR_1093|M.marinum_M GTGLFMGSGRTIS-LAGPAVIVVYAVIGFFVFFVLRAMGELLLSNLNYKS MUL_0851|M.ulcerans_Agy99 GTGLFMGSGRTIS-LAGPAVIVVYAVIGFFVFFVLRAMGELLLSNLNYKS MSMEG_3587|M.smegmatis_MC2_155 GTGLFMGSGKTVS-LAGPSVIFVYMIIGFMLFFVMRAMGELLLSNLEYKS MAB_3866c|M.abscessus_ATCC_199 GTGLFYGAGGAIE-KAGPGLILTYLVAGLAIFVIMRALGELLVYRPVSGS MLBr_01305|M.leprae_Br4923 GTGLFLGAGGRLA-KAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGS Mflv_1998|M.gilvum_PYR-GCK GAGLFVGSGVVIA-DTGPGAFLTYGMAGVLIIMVMRMLAEMAVANPSTGS MAV_4626|M.avium_104 GAGLFVGSGVVIK-DTGPAAFLTYALCGLLIVLVMRMLGEMAAANPSTGS TH_0471|M.thermoresistible__bu GAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGS Mvan_1740|M.vanbaalenii_PYR-1 GAGIFTITASTAANITGPAISLSFIIAAIACGLAALCYAEFASTVPVAGS *:*:* :. :**. . : : .. . .*: * Rv1704c|M.tuberculosis_H37Rv FVDFAADLRGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFW--WPGLP Mb1730c|M.bovis_AF2122/97 FVDFAADLLGPAAGFFVGWSYWFAWVVTGIADLVAITGYARFW--WPGLP MMAR_1093|M.marinum_M FVDCAADLLGPAAGYFMGWSYWFAWIVAGIADLVAITGYSKFW--WPDVP MUL_0851|M.ulcerans_Agy99 FVDCAADLLGPAAGYFMGWSYWFAWIVAGIADLVAITGYSKFW--WPDVP MSMEG_3587|M.smegmatis_MC2_155 FADFAADLLGPWAGFFTGWTYWFCWIVTGVAEVVAIAGYVAFW--WPDLP MAB_3866c|M.abscessus_ATCC_199 ISEYAEEFMGRFAGFANGWTYWAVWATTCMAEITVAGVYIQRW--WPGIP MLBr_01305|M.leprae_Br4923 FVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHRWTIFTALP Mflv_1998|M.gilvum_PYR-GCK FADYSRNALGHWAGFSVGWLYWYFWVIVVGFEAIAGAKIVQYW---MDVP MAV_4626|M.avium_104 FADYAAAALGRWAGFSVAWLYWYFWVIVVGFEAVAGGKVLNYW---FHAP TH_0471|M.thermoresistible__bu AYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLGEVFEFAGAT Mvan_1740|M.vanbaalenii_PYR-1 AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLGTVFGFAGGT : * ..: .* : . . Rv1704c|M.tuberculosis_H37Rv IWVP-------ALVTVALILAVNLFSVRHFGELEFWFALIKVAAIVCLIA Mb1730c|M.bovis_AF2122/97 IWVP-------ALVTVALILAVNLFSVRHFGELEFWFALIKVAAIVCLIA MMAR_1093|M.marinum_M TWAP-------ALVTIAVMLSINMFGVSKFGETEFWFALIKVAAILCLIT MUL_0851|M.ulcerans_Agy99 TWAP-------ALVTIAVMLSINMFGVSKFGGTEFWFALIKVAAILCLIT MSMEG_3587|M.smegmatis_MC2_155 LWIP-------ALVTVAVLITLNLATVRAFGETEFWFAMIKIVAILALIV MAB_3866c|M.abscessus_ATCC_199 QWVT-------ALVVLLILFGANLISVKIFGEAEFWFSMIKVTAILGMII MLBr_01305|M.leprae_Br4923 QWTL-------ALLALAVVLVMNLISVEWFGELEFWAALIKVCALMAFLV Mflv_1998|M.gilvum_PYR-GCK LWLS-------ALIFMVLMTATNLFSVASYGEFEFWFAGIKVAAIIAFIA MAV_4626|M.avium_104 LWVL-------SLGLMLLMTATNLFSVSSFGEFEFWFAGIKVATIVIFLV TH_0471|M.thermoresistible__bu TRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITVIKVGVVLLVVI Mvan_1740|M.vanbaalenii_PYR-1 TEVAGFQLDWGALVIIALVTLILVMGTKLSAGVSLAITAVKVSVVLLVVI :* : .: . . .: : :*: .:: .: Rv1704c|M.tuberculosis_H37Rv VGA------------ILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVV Mb1730c|M.bovis_AF2122/97 VGA------------ILVATNFVSPHGVHATIENLWNDNGFFPTGFLGVV MMAR_1093|M.marinum_M VGA------------ILVITGFTSPDGDRAALANLWNDGGFFPTGFVGLA MUL_0851|M.ulcerans_Agy99 VGA------------ILVITGFTSPDGDRAALANLWNDGGFFPTGFVGLA MSMEG_3587|M.smegmatis_MC2_155 VGL------------VMVLSHFRAPGGAVASLSNLWDDGGFFPTGPMGFV MAB_3866c|M.abscessus_ATCC_199 IGVG----------VLLPISGLGPETG--PSVANLWNDGGVFPTGFSQAL MLBr_01305|M.leprae_Br4923 VGT-------------IFLGGRYPVDGHNTGLSLWTSHGGLFPTGVAPLI Mflv_1998|M.gilvum_PYR-GCK VGA---------------AFVLGLWPGKGADFSNLTSHGGFMPLGFGAIT MAV_4626|M.avium_104 VGA---------------AYVIGLVPGHHDGLTNLVSHGGFFPRGVGAVF TH_0471|M.thermoresistible__bu VGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGWYGLL Mvan_1740|M.vanbaalenii_PYR-1 VGAFYIKAENFSPFVPAPEEGGSGGTGTEQSLFSLLTGAEGSHYGWYGVL :* . . * Rv1704c|M.tuberculosis_H37Rv SGFQIAFFAYIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALL Mb1730c|M.bovis_AF2122/97 SGFQIAFFAYIGVELVGTAAAETADPRRTLPRAINAVPLRVAVFYIGALL MMAR_1093|M.marinum_M SGFQIAFFAYIGVELVGAAAAEAADPSHTLPRAINAVPLRVAIFYIGALL MUL_0851|M.ulcerans_Agy99 SGFQIAFFAYIGVELVGAAAAEAADPSHTLPRAINAVPLRVAIFYIGALL MSMEG_3587|M.smegmatis_MC2_155 AGFQIATFAFVGIELVGTTAAEARDPERNLPRAVNSIPVRVMLFYVAALV MAB_3866c|M.abscessus_ATCC_199 LSLQIVVFAYVGVELVGVTAGEAENPKVTLRKAINTLPFRIGLFYVGALI MLBr_01305|M.leprae_Br4923 VVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAINSVIARIAIFYVGSVI Mflv_1998|M.gilvum_PYR-GCK VGIVTVIFSMVGAEIATIAAAESQDPERAVAKAANSVILRILIFYVGAVL MAV_4626|M.avium_104 AAIVVVIFSMVGAEIVTVAAAESRDPRRAVQKATRSVVTRIGIFFVGSVF TH_0471|M.thermoresistible__bu AGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYVAVSL Mvan_1740|M.vanbaalenii_PYR-1 AGASIVFFAFIGFDIVATTAEETRNPQRDVPRGILASLAIVTVLYVAVAV . *: . :: :* *: :* : :. : : ::::. . Rv1704c|M.tuberculosis_H37Rv AILAVVPWRQFASG--ESPFVTMFSLAGLAAAASVVNFVVVTAAASSANS Mb1730c|M.bovis_AF2122/97 AILAVVPWRQFASG--ESPFVTMFSLAGLAAAASVVNFVVVTAAASSANS MMAR_1093|M.marinum_M AILSVVPWRRFASG--ESPFVTMFALAGLAAAASVVNFVVITSAASSANS MUL_0851|M.ulcerans_Agy99 AILSVVPWRRFASG--ESPFVTMFALAGLAAAASVVNFVVITSAASSANS MSMEG_3587|M.smegmatis_MC2_155 IIIAVTPWREISPD--RSPFVAMFSLAGLGIAASVVNFVVLTSAASSANS MAB_3866c|M.abscessus_ATCC_199 VILSIQGWRNYHKG--ESPFVAVFEYLNIPQAANIVNFILLTAALSSCNS MLBr_01305|M.leprae_Br4923 LLALLLPYSAFKAS--ESPFVTFFSKVGFYGAGDLMNIVVLTAALSSLNA Mflv_1998|M.gilvum_PYR-GCK LLVLIVPWNDESVS--ASPFVAAFNAMGIPYADHVMNAVVLTAVLSCLNS MAV_4626|M.avium_104 LLVAILPWDSVELG--ASPYVAALKHLGLAGADQVMNAVVLTAVLSCLNS TH_0471|M.thermoresistible__bu VLTGMVHYTELRAAGENANLATAFAANGIDWAAKVISIGALAGLTTVVIV Mvan_1740|M.vanbaalenii_PYR-1 VLTGMVSYTELRDA-ETQNLATAFSLNGVDWAAKVISIGALAGLTTVVIV : : : .: : .. * ::. ::. : Rv1704c|M.tuberculosis_H37Rv GFFSTGRMLFGLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLLY Mb1730c|M.bovis_AF2122/97 GFFSTGRMLFGLADEGHAPAAFHQLNRGGVPAPALLLTAPLLLTSIPLLY MMAR_1093|M.marinum_M GVFSTGRMLYGLADEGSAPGIFGRLNRRGVPAPALILTAALLLSAIPLLY MUL_0851|M.ulcerans_Agy99 GVFSTGRMLYGLADEGSAPGIFGRLNSRGVPAPALILTAALLLSAIPLLY MSMEG_3587|M.smegmatis_MC2_155 GIYSTSRMVYGLSCGGDAPASFGRLTSRRVPANALFLSGVVLLSSVVMVA MAB_3866c|M.abscessus_ATCC_199 GIYSTGRMVRSLAQRGDAPAGLQALSSRHVPMLAICFSALAMG--IGVFV MLBr_01305|M.leprae_Br4923 GLYATGRVMHSIAINGSGPKFTARMSKNGVPYGGILLAAVICLCGVALNA Mflv_1998|M.gilvum_PYR-GCK GMYTASRMLFVLAARREAPAALVKVTNRGVPANAILASSVVGFLCVIAAA MAV_4626|M.avium_104 GLYTASRMLFVLAERGEAPARLVRLSGRGVPHIAILCSSAVGFLCVVMAR TH_0471|M.thermoresistible__bu LVLGQTRVLFAMSRDGLLPRPLSKTGPRGTPVRITVLVGALVAIAASVFP Mvan_1740|M.vanbaalenii_PYR-1 LVLGQTRVLFAMSRDGLLPRQLAKTGEHGTPVRITLIVGAVVAVTATVFP . *:: :: * .* . Rv1704c|M.tuberculosis_H37Rv AGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQ-RHTDSVYKM Mb1730c|M.bovis_AF2122/97 AGRSVIGAFTLVTTVSSLLFMFVWAMIIISYLVYRRRHPQ-RHTDSVYKM MMAR_1093|M.marinum_M AGGSVIGAFTLITTISSLLFMFVWTMIVISYLVYRRRHAQ-RHADSAYKM MUL_0851|M.ulcerans_Agy99 AGGSVTGAFTLITTISSLLFMFVWTMIVISYLVYRRRHAQ-RHADSAYKM MSMEG_3587|M.smegmatis_MC2_155 AGDSIIAAFTLVTTISSLCFMFIWTIILSSYLVYRRRRPQ-QHSASPFKM MAB_3866c|M.abscessus_ATCC_199 NWLSPDKAFAYITSVSTIGIIFVWGSILVSHMIYRKRVADGLLPASDYKL MLBr_01305|M.leprae_Br4923 FNPG--QAFEIVLSVAALGIIAGWGTIVLCQLRLHKMAKAGIMRRPRFRM Mflv_1998|M.gilvum_PYR-GCK VSPD--TIFAFLLNSSGAIILFVYLLIAISQIVLRYRTPDSKLRVKMWLF MAV_4626|M.avium_104 VAPN--TVFLFLLNSSGAIILFVYWLIALSQIVLRRRTPAERLSVKMWFF TH_0471|M.thermoresistible__bu --------VGNLEEMVNIGTLFAFALVSAGVIVLRRTRPDLKRGFRVPFV Mvan_1740|M.vanbaalenii_PYR-1 --------IGKLEEMVNIGTLFAFVLVSAGVLVLRRTRPDLKRGFRTPWV . : : : : : : . Rv1704c|M.tuberculosis_H37Rv PGGVVMCWAVLVFFAFVIWTLT----TETETATALAWFPLWFVLLAVGWL Mb1730c|M.bovis_AF2122/97 PGGVVMCWAVLVFFAFVIWTLT----TETETATALAWFPLWFVLLAVGWL MMAR_1093|M.marinum_M PGGVVMCWAILGFFVFVIWTLT----TETETATALVWFPLWFVILGIGWA MUL_0851|M.ulcerans_Agy99 PGGVVMCWAILGFFVFVIWTLTTETETETETATALVWFPLWFVILGIGWA MSMEG_3587|M.smegmatis_MC2_155 PGGVVMCWVVLAFFVFLVWAFT----QKSDTLQALLVTPAWFVVLGIAWA MAB_3866c|M.abscessus_ATCC_199 PGAPVTNILALGFLALVVLLLF----FTEDGRTAILVGVVWFIIVVLGYF MLBr_01305|M.leprae_Br4923 PLAPYSGYLTLAFLFAVLVVMA---FDKPIGTWTVASLIVIVPALIAGWY Mflv_1998|M.gilvum_PYR-GCK P--VLSGLTALGILAILVQMFIDTALRSQLVLSLLSWAVVIALFAANKWF MAV_4626|M.avium_104 P--VLSVLTLAGITAVLVQMAFDATARSQLWLSLLSWAVVVALY-----F TH_0471|M.thermoresistible__bu PWLPLAAIAACLWLMLNLTGLT-----WVRFLGWMALGLVLYFFYGRHHS Mvan_1740|M.vanbaalenii_PYR-1 PLLPILAIAACVWLMLNLTGLT-----WIRFLIWMAIGVVVYFLYGRRHS * : : Rv1704c|M.tuberculosis_H37Rv VTQRRQSRRSFGFH----CQVVGVRQQLGRGMARLAMKIHARPKLRSAVV Mb1730c|M.bovis_AF2122/97 VTQRRQSRRSFGFH----CQVVGVRQQLGRGMARLAMKIHARPKLRSAVV MMAR_1093|M.marinum_M LVRRRP----------------GHLEQYHR----FQAEMNG--------T MUL_0851|M.ulcerans_Agy99 LVRRRP----------------GHLEQYHR----FQAEMNG--------T MSMEG_3587|M.smegmatis_MC2_155 FLRRRL----------------GHKAR--------EAAFRA--------A MAB_3866c|M.abscessus_ATCC_199 VH-------------------------------------HG--------- MLBr_01305|M.leprae_Br4923 SIRKRVMT--------------------------IARERMGYTGPFPAIA Mflv_1998|M.gilvum_PYR-GCK VKKRPAEGDSGAPTGPPHRVLVLANRTVDSDELLAELSRIGADQTAEYLV MAV_4626|M.avium_104 VAR--SRGRVAAR------------------------------------- TH_0471|M.thermoresistible__bu MLGRGMTD------------------------------------------ Mvan_1740|M.vanbaalenii_PYR-1 LVGRRMG------------------------------------------- Rv1704c|M.tuberculosis_H37Rv VEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHD Mb1730c|M.bovis_AF2122/97 VEPVSAGEPGARRSAKSVRKLASDDSQSAHCPVAVVGLADGGRDPQYHHD MMAR_1093|M.marinum_M TEGILPPDASART------------------------------------- MUL_0851|M.ulcerans_Agy99 AEGVLPPDASART------------------------------------- MSMEG_3587|M.smegmatis_MC2_155 LEAESADSAD---------------------------------------- MAB_3866c|M.abscessus_ATCC_199 -EPAHRETQDA--------------------------------------- MLBr_01305|M.leprae_Br4923 NPPVQPSERSHSQNP----------------------------------- Mflv_1998|M.gilvum_PYR-GCK VVPASAVDTGAAATHGPRDVTEATQEAATARLESTLAALRGKNLTVQGEL MAV_4626|M.avium_104 -------------------------------------------------- TH_0471|M.thermoresistible__bu ---ISARRTG---------------------------------------- Mvan_1740|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1704c|M.tuberculosis_H37Rv GPDR---------------------------------------------- Mb1730c|M.bovis_AF2122/97 GPDR---------------------------------------------- MMAR_1093|M.marinum_M -------------------------------------------------- MUL_0851|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3587|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3866c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01305|M.leprae_Br4923 -------------------------------------------------- Mflv_1998|M.gilvum_PYR-GCK GDYRPLRALDHAVAEFGPDQIVIATLPPEFSMWHRFDVVDRARAQFTVPV MAV_4626|M.avium_104 -------------------------------------------------- TH_0471|M.thermoresistible__bu -------------------------------------------------- Mvan_1740|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1704c|M.tuberculosis_H37Rv --------------- Mb1730c|M.bovis_AF2122/97 --------------- MMAR_1093|M.marinum_M --------------- MUL_0851|M.ulcerans_Agy99 --------------- MSMEG_3587|M.smegmatis_MC2_155 --------------- MAB_3866c|M.abscessus_ATCC_199 --------------- MLBr_01305|M.leprae_Br4923 --------------- Mflv_1998|M.gilvum_PYR-GCK THVVATSAVGNQVPR MAV_4626|M.avium_104 --------------- TH_0471|M.thermoresistible__bu --------------- Mvan_1740|M.vanbaalenii_PYR-1 ---------------