For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VSGQRSRRQWGWYPLTDDWAARIVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVELHPGRARHLR SRFAEEDVRIAEADLLAFRWPRRPFRVVASPPYQVTSALIRSLLTPESRLLAADLVLQRGAVHKHAKRAP VRHWTLRAGITLPRSAFHHPPQVDSSVLVIRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2297 | - | - | 100% (173) | methyltransferase |
| M. abscessus ATCC 19977 | MAB_1131 | ksgA | 4e-07 | 32.41% (108) | dimethyladenosine transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2010 | - | 3e-50 | 59.76% (169) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_1933 | ksgA | 3e-07 | 31.67% (120) | dimethyladenosine transferase |
| M. tuberculosis H37Rv | Rv1988 | - | 3e-50 | 59.76% (169) | methyltransferase |
| M. leprae Br4923 | MLBr_00241 | ksgA | 3e-08 | 30.17% (116) | dimethyladenosine transferase |
| M. marinum M | MMAR_4513 | - | 6e-07 | 33.01% (103) | hypothetical protein MMAR_4513 |
| M. avium 104 | MAV_1148 | ksgA | 3e-07 | 31.03% (116) | dimethyladenosine transferase |
| M. smegmatis MC2 155 | MSMEG_1646 | - | 4e-10 | 30.22% (182) | ribosomal RNA adenine dimethylase family protein |
| M. thermoresistible (build 8) | TH_0980 | ksgA | 8e-06 | 32.04% (103) | PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA |
| M. ulcerans Agy99 | MUL_4684 | - | 5e-07 | 34.57% (81) | hypothetical protein MUL_4684 |
| M. vanbaalenii PYR-1 | Mvan_4800 | ksgA | 8e-07 | 30.00% (120) | dimethyladenosine transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2010|M.bovis_AF2122/97 --------------------------MSALGRSRRAWGWHRLHDEWAAR-
Rv1988|M.tuberculosis_H37Rv --------------------------MSALGRSRRAWGWHRLHDEWAAR-
MAB_2297|M.abscessus_ATCC_1997 --------------------------MSGQ-RSRRQWGWYPLTDDWAAR-
MLBr_00241|M.leprae_Br4923 ---MQRKSGCTLTIRLLERTEIRWLVKELECRPRKSLGQNFVHDANTVRR
MAV_1148|M.avium_104 MASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRR
Mflv_1933|M.gilvum_PYR-GCK -----------MTIRLLGRTEIRHLAKSIDFRPRKSFGQNFVHDANTVRR
Mvan_4800|M.vanbaalenii_PYR-1 -----------MTIRLLGRTEIRHLAKSIDFRPRKSFGQNFVHDANTVRR
TH_0980|M.thermoresistible__bu -----------------------------------------------VRR
MMAR_4513|M.marinum_M ---------------------MGRVALTESDEYARQYFDEQAESNKEYWR
MUL_4684|M.ulcerans_Agy99 ---------------------MGRVALTESEEYARQYFDEQAESNNEYWR
MSMEG_1646|M.smegmatis_MC2_155 --------------------------MSTPHHGRHELGQNFLSDRRVIAD
Mb2010|M.bovis_AF2122/97 VVSAAAVRPGELVFDIGAGEGALTAHLVRAGARVVAVELHPRRVGVLRER
Rv1988|M.tuberculosis_H37Rv VVSAAAVRPGELVFDIGAGEGALTAHLVRAGARVVAVELHPRRVGVLRER
MAB_2297|M.abscessus_ATCC_1997 IVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSR
MLBr_00241|M.leprae_Br4923 VVSTSRVNRSDFVLEVGPGFGSLTLALLDCGAAVSAIEIDPVLAGRLPQT
MAV_1148|M.avium_104 VVSTSGVSRSDHVLEVGPGLGSLTLALLDRGAHVTAVEIDPVLAERLPHT
Mflv_1933|M.gilvum_PYR-GCK IVSASSVNRSDHVLEVGPGLGSLTLALLDRGARVTAVEIDPVLATQLPTT
Mvan_4800|M.vanbaalenii_PYR-1 IVSASSINRSDHVLEVGPGLGSLTLALLDRGAKVTAVEIDPVLANQLPTT
TH_0980|M.thermoresistible__bu IVSASGINKQDHVLEVGPGLGSLTLGLLDRGAHVTAVEIDSVLARQLPKT
MMAR_4513|M.marinum_M RFGVVPDWAGKRVLDVGCGHGALSIDIAQAGASVLGVDLDEGRVAFANRN
MUL_4684|M.ulcerans_Agy99 RFGVVPDWAGKRVLDVGCGHGALSIDIAQAGASVLGVDLDEGRVAFANRN
MSMEG_1646|M.smegmatis_MC2_155 IVEIVSRTNG-PIIEIGAGDGALTIPLQRLARPLTAVEVDARRARRLAQR
. :.::* * *:*: : . : .:::. .
Mb2010|M.bovis_AF2122/97 FP---------GITVVHADAASIR---LPGRPFRVVANPPYGISSRLLRT
Rv1988|M.tuberculosis_H37Rv FP---------GITVVHADAASIR---LPGRPFRVVANPPYGISSRLLRT
MAB_2297|M.abscessus_ATCC_1997 FAEE-------DVRIAEADLLAFR---WPRRPFRVVASPPYQVTSALIRS
MLBr_00241|M.leprae_Br4923 VAEHSN-NEIHRLTVCNRDVLSFRRGDLATEPTALVANLPYNVAVPALLH
MAV_1148|M.avium_104 VAEHSH-SEIQRLTVLNRDVLTLRRDELAEPPTAVVANLPYNVAVPALLH
Mflv_1933|M.gilvum_PYR-GCK IAAHSH-SEVNRLTVLNRDILTFKQSDMTEMPTALVANLPYNVAVPALLH
Mvan_4800|M.vanbaalenii_PYR-1 IAAHSH-SEVNRLTVLNRDILTFKQSDMTEMPTALVANLPYNVAVPALLH
TH_0980|M.thermoresistible__bu IADHSH-SEINRLIVLNRDILDLYPQDLETQPTALVANLPYNVAVPALLH
MMAR_4513|M.marinum_M LAQRFP-ELADRVRFRAVDVRSLP----VDEPFDVIVSKDTFEHVADVAT
MUL_4684|M.ulcerans_Agy99 LAQRFP-EQADRVRFRAVDVRSLP----VDEPFDVIVSKDTFEHVADVAS
MSMEG_1646|M.smegmatis_MC2_155 TARSAPGPASRPTEVVAADFLRYP---LPRSPHVVVGNLPFHLTTAILRR
. . * * :: . :
Mb2010|M.bovis_AF2122/97 LLAPNSGLVAADLVLQRALVCKFASRN-ARRFTLTVG-----------LM
Rv1988|M.tuberculosis_H37Rv LLAPNSGLVAADLVLQRALVCKFASRN-ARRFTLTVG-----------LM
MAB_2297|M.abscessus_ATCC_1997 LLTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAG-----------IT
MLBr_00241|M.leprae_Br4923 LLAEFPSIRTVTVMVQAEVAERLAAEPGGKDYGVPSVKLSFFGRVRRCGM
MAV_1148|M.avium_104 LLAEFPSIRTVTVMVQAEVAERLAAEPGGKEYGVPSVKVRFFGRVRRCGM
Mflv_1933|M.gilvum_PYR-GCK LLAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFFGNVRRYGM
Mvan_4800|M.vanbaalenii_PYR-1 LLAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFFGNVRRYGM
TH_0980|M.thermoresistible__bu LLAEFPTIRTVMVMVQAEVAERLAAEPGSKEYGVPSAKVRFYGNVRRYGM
MMAR_4513|M.marinum_M LLRALGERLTRPGGRIYAGFSPLYYSP-FGDHGRTGLKVPWAHAILPKRL
MUL_4684|M.ulcerans_Agy99 LLLALGERLTRPGGRIYAGFSPLYYSP-FGDHGRTGLKVPWTHAILPKRL
MSMEG_1646|M.smegmatis_MC2_155 LLHG-PGWTTAVLLMQWEVARRRAAVGGATMMTAQWWPWFEFG---LARK
** :
Mb2010|M.bovis_AF2122/97 LPRRAFLPPPHVDSAVLVVRRR-----KCGDWQGR---------------
Rv1988|M.tuberculosis_H37Rv LPRRAFLPPPHVDSAVLVVRRR-----KCGDWQGR---------------
MAB_2297|M.abscessus_ATCC_1997 LPRSAFHHPPQVDSSVLVIRRR----------------------------
MLBr_00241|M.leprae_Br4923 VSPTVFWPIPRVYSGLVRVDRY-----ATSPWPTDDAFRRQVFELVDIAF
MAV_1148|M.avium_104 VSPTVFWPIPRVYSGLVRIDRY-----PTSPWPTDPAFRRQVFQLVDIAF
Mflv_1933|M.gilvum_PYR-GCK VSPTVFWPIPRVYSGLVRIDRY-----ETSPWPTDTEFQEQVFELIDIAF
Mvan_4800|M.vanbaalenii_PYR-1 VSPTVFWPIPRVYSGLVRIDRY-----ETSPWPTDPEFRQQVFELIDVAF
TH_0980|M.thermoresistible__bu VSPTVFWPIPRVYSGLVRLDRY-----ESPKWPMDAEFRERVFELIDIAF
MMAR_4513|M.marinum_M VFAAAARKYGHPVGSLLDIGLN-----GNTPDQFRAAFDNSGLRQLDIGY
MUL_4684|M.ulcerans_Agy99 VFAVAARKYGHPVGSLLDIGLN-----GNTPDQFRAAFDNSGLRQLDIGY
MSMEG_1646|M.smegmatis_MC2_155 VSAASFTPRPAVDAGLLTITRRSRPLVDVADRARYQALVHRVFTGRGHGM
: ..:: :
Mb2010|M.bovis_AF2122/97 --------------------------------------------------
Rv1988|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2297|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00241|M.leprae_Br4923 TQRRKTSRNAFVKWAGSSNESANRLLAASIDPARRGETLSIDDFVRLLRR
MAV_1148|M.avium_104 GQRRKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQR
Mflv_1933|M.gilvum_PYR-GCK AQRRKTSRNAFAEWAGSGNESASRLLAASIDPSRRGETLSINDFVRLLQR
Mvan_4800|M.vanbaalenii_PYR-1 AQRRKTSRNAFAEWAGSGNESASRLLAASIDPSRRGETLSINDFVRLLQR
TH_0980|M.thermoresistible__bu AQRRKTSRNAFAQWAGSGNESARRLLAASIDPARRGETLSIADFVRLLQR
MMAR_4513|M.marinum_M NRG------------------AKRLLPALERARRHWRRFDRFTTVSIYAV
MUL_4684|M.ulcerans_Agy99 NRG------------------AKRLLPALERARRHWRRFDRFTTVSIYAV
MSMEG_1646|M.smegmatis_MC2_155 AQIRQRLPTPVPRTWLRANGIAPNSLPRQLSAAQWAALFEQTRLTGAQRV
Mb2010|M.bovis_AF2122/97 --------------------------------------------------
Rv1988|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2297|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00241|M.leprae_Br4923 SDGR---DDAAVRSASAS--------------------------------
MAV_1148|M.avium_104 SADRGGSDREGTSPPTAGQGAPAC--------------------------
Mflv_1933|M.gilvum_PYR-GCK SADWHTVPKADDAGDDADAQAKADGAQVSTL-------------------
Mvan_4800|M.vanbaalenii_PYR-1 SADWHVVPKPESA---ATAVATDEDAQVPTL-------------------
TH_0980|M.thermoresistible__bu TDEVAAPAEK----------------------------------------
MMAR_4513|M.marinum_M FGV-----------------------------------------------
MUL_4684|M.ulcerans_Agy99 FGV-----------------------------------------------
MSMEG_1646|M.smegmatis_MC2_155 DRPRDVQHGRAHRRRGGEVDRPATHHKQTGPVVGQRQPQRGRDADADPDD
Mb2010|M.bovis_AF2122/97 --------------------------------------------------
Rv1988|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2297|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00241|M.leprae_Br4923 --------------------------------------------------
MAV_1148|M.avium_104 --------------------------------------------------
Mflv_1933|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4800|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0980|M.thermoresistible__bu --------------------------------------------------
MMAR_4513|M.marinum_M --------------------------------------------------
MUL_4684|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_1646|M.smegmatis_MC2_155 QRTAPPVTRHHQGERRDEDQADHQDRPLTGEHLAGEFLWRHASFDSSAST
Mb2010|M.bovis_AF2122/97 --------------------
Rv1988|M.tuberculosis_H37Rv --------------------
MAB_2297|M.abscessus_ATCC_1997 --------------------
MLBr_00241|M.leprae_Br4923 --------------------
MAV_1148|M.avium_104 --------------------
Mflv_1933|M.gilvum_PYR-GCK --------------------
Mvan_4800|M.vanbaalenii_PYR-1 --------------------
TH_0980|M.thermoresistible__bu --------------------
MMAR_4513|M.marinum_M --------------------
MUL_4684|M.ulcerans_Agy99 --------------------
MSMEG_1646|M.smegmatis_MC2_155 TLVSRKARVNGPTPPGLGDT