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VSALGRSRRAWGWHRLHDEWAARVVSAAAVRPGELVFDIGAGEGALTAHLVRAGARVVAVELHPRRVGVL RERFPGITVVHADAASIRLPGRPFRVVANPPYGISSRLLRTLLAPNSGLVAADLVLQRALVCKFASRNAR RFTLTVGLMLPRRAFLPPPHVDSAVLVVRRRKCGDWQGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1988 | - | - | 100% (179) | PROBABLE METHYLTRANSFERASE |
| M. tuberculosis H37Rv | Rv1010 | ksgA | 1e-10 | 28.57% (196) | dimethyladenosine transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2010 | - | 1e-100 | 100.00% (179) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_1933 | ksgA | 4e-10 | 26.96% (204) | dimethyladenosine transferase |
| M. leprae Br4923 | MLBr_00241 | ksgA | 1e-09 | 30.07% (143) | dimethyladenosine transferase |
| M. abscessus ATCC 19977 | MAB_2297 | - | 4e-50 | 59.76% (169) | methyltransferase |
| M. marinum M | MMAR_4478 | ksgA | 7e-09 | 27.07% (181) | dimethyladenosine transferase KsgA |
| M. avium 104 | MAV_1148 | ksgA | 4e-10 | 29.50% (200) | dimethyladenosine transferase |
| M. smegmatis MC2 155 | MSMEG_5438 | ksgA | 5e-10 | 27.86% (201) | dimethyladenosine transferase |
| M. thermoresistible (build 8) | TH_1247 | - | 2e-06 | 36.25% (80) | SAM-dependent methyltransferase |
| M. ulcerans Agy99 | MUL_4650 | ksgA | 6e-09 | 27.07% (181) | dimethyladenosine transferase |
| M. vanbaalenii PYR-1 | Mvan_4800 | ksgA | 1e-09 | 25.98% (204) | dimethyladenosine transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1988|M.tuberculosis_H37Rv --------------------------MSALGRSRRAWGWHRLHDEWAAR-
Mb2010|M.bovis_AF2122/97 --------------------------MSALGRSRRAWGWHRLHDEWAAR-
MAB_2297|M.abscessus_ATCC_1997 --------------------------MSGQ-RSRRQWGWYPLTDDWAAR-
Mflv_1933|M.gilvum_PYR-GCK -----------MTIRLLGRTEIRHLAKSIDFRPRKSFGQNFVHDANTVRR
Mvan_4800|M.vanbaalenii_PYR-1 -----------MTIRLLGRTEIRHLAKSIDFRPRKSFGQNFVHDANTVRR
MSMEG_5438|M.smegmatis_MC2_155 ------------------------MAKEIDFRPRKAFGQNFVHDANTVRR
MLBr_00241|M.leprae_Br4923 ---MQRKSGCTLTIRLLERTEIRWLVKELECRPRKSLGQNFVHDANTVRR
MAV_1148|M.avium_104 MASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANTVRR
MMAR_4478|M.marinum_M -----------------------------------------------MRK
MUL_4650|M.ulcerans_Agy99 -----------------------------------------------MRK
TH_1247|M.thermoresistible__bu -----------MVEKSLWMRKVEADPGHSQWYIERFRAMARAGEDLVGEA
.
Rv1988|M.tuberculosis_H37Rv VVSAAAVRPGELVFDIGAGEGALTAHLVRAGARVVAVELHPRRVGVLRER
Mb2010|M.bovis_AF2122/97 VVSAAAVRPGELVFDIGAGEGALTAHLVRAGARVVAVELHPRRVGVLRER
MAB_2297|M.abscessus_ATCC_1997 IVAESGVRSGEFVVDLGAGHGALTAHLVAAGARVLAVELHPGRARHLRSR
Mflv_1933|M.gilvum_PYR-GCK IVSASSVNRSDHVLEVGPGLGSLTLALLDRGARVTAVEIDPVLATQLPTT
Mvan_4800|M.vanbaalenii_PYR-1 IVSASSINRSDHVLEVGPGLGSLTLALLDRGAKVTAVEIDPVLANQLPTT
MSMEG_5438|M.smegmatis_MC2_155 IVSASGVHRHDHVLEVGPGLGSLTLALLDRGARVTAVEIDPLLARQLPTT
MLBr_00241|M.leprae_Br4923 VVSTSRVNRSDFVLEVGPGFGSLTLALLDCGAAVSAIEIDPVLAGRLPQT
MAV_1148|M.avium_104 VVSTSGVSRSDHVLEVGPGLGSLTLALLDRGAHVTAVEIDPVLAERLPHT
MMAR_4478|M.marinum_M VVTVSGITRSDQVLEVGPGLGSLTLALLERGAAVTAVEIDPVLAARLPQT
MUL_4650|M.ulcerans_Agy99 VVAVSGTTRSDQVLEVGPGLGSLTLALLERGAAVTAVEIDPVLAARLPQT
TH_1247|M.thermoresistible__bu RLVDAMAPRNAHILDAGCGPGRLGGYLSAAGHRVVGVDVDPALIEAAEQD
: : :.: * * * * * * * .:::.*
Rv1988|M.tuberculosis_H37Rv FP--------GITVVHADAASIR---LPGRPFRVVANPPYGISSRLLRTL
Mb2010|M.bovis_AF2122/97 FP--------GITVVHADAASIR---LPGRPFRVVANPPYGISSRLLRTL
MAB_2297|M.abscessus_ATCC_1997 FAEE------DVRIAEADLLAFR---WPRRPFRVVASPPYQVTSALIRSL
Mflv_1933|M.gilvum_PYR-GCK IAAHSHSEVNRLTVLNRDILTFKQSDMTEMPTALVANLPYNVAVPALLHL
Mvan_4800|M.vanbaalenii_PYR-1 IAAHSHSEVNRLTVLNRDILTFKQSDMTEMPTALVANLPYNVAVPALLHL
MSMEG_5438|M.smegmatis_MC2_155 IADHSHSEINRLTVLNRDILTLMPGDLEEQPTALVANLPYNVAVPALLHL
MLBr_00241|M.leprae_Br4923 VAEHSNNEIHRLTVCNRDVLSFRRGDLATEPTALVANLPYNVAVPALLHL
MAV_1148|M.avium_104 VAEHSHSEIQRLTVLNRDVLTLRRDELAEPPTAVVANLPYNVAVPALLHL
MMAR_4478|M.marinum_M VAEHSDSEIGRLTVVHHDILTLRRQDVADQPTAVVANLPYNVAVPALLHL
MUL_4650|M.ulcerans_Agy99 VAEHSDSEIGRLTVVHHDILTLRRQDVADQPTAVVANLPYNVAVPALLHL
TH_1247|M.thermoresistible__bu YPGP------QYLVGDLAELDLPARGIPDP-FDVIVMAGNVMAFLAPSTR
. : . : ::. ::
Rv1988|M.tuberculosis_H37Rv LAPNSGLVAADLVLQRALVCKFASRN-ARRFTLTVG-----------LML
Mb2010|M.bovis_AF2122/97 LAPNSGLVAADLVLQRALVCKFASRN-ARRFTLTVG-----------LML
MAB_2297|M.abscessus_ATCC_1997 LTPESRLLAADLVLQRGAVHKHAKRAPVRHWTLRAG-----------ITL
Mflv_1933|M.gilvum_PYR-GCK LAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFFGNVRRYGMV
Mvan_4800|M.vanbaalenii_PYR-1 LAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFFGNVRRYGMV
MSMEG_5438|M.smegmatis_MC2_155 LAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFYGNVRRHGMV
MLBr_00241|M.leprae_Br4923 LAEFPSIRTVTVMVQAEVAERLAAEPGGKDYGVPSVKLSFFGRVRRCGMV
MAV_1148|M.avium_104 LAEFPSIRTVTVMVQAEVAERLAAEPGGKEYGVPSVKVRFFGRVRRCGMV
MMAR_4478|M.marinum_M LAEFPSIRVVTVMVQAEVAERLAAEPGGKEYGVPSVKVGFYGRVRRCGMV
MUL_4650|M.ulcerans_Agy99 LAEFPSIRVVTVMVQAEVAERLAAEPGGKEYGVPSVKVGFYGRVRRCGMV
TH_1247|M.thermoresistible__bu TTVLSRLRAHLAEDGRAAIGFGAGRDYDFDEFLADAATAG---LTPDLLL
: . : . * . : :
Rv1988|M.tuberculosis_H37Rv PRRAFLPPPHVDSAVLVVRRRKCGDWQGR---------------------
Mb2010|M.bovis_AF2122/97 PRRAFLPPPHVDSAVLVVRRRKCGDWQGR---------------------
MAB_2297|M.abscessus_ATCC_1997 PRSAFHHPPQVDSSVLVIRRR-----------------------------
Mflv_1933|M.gilvum_PYR-GCK SPTVFWPIPRVYSGLVRIDRYETSPWPTDTEFQEQVFELIDIAFAQRRKT
Mvan_4800|M.vanbaalenii_PYR-1 SPTVFWPIPRVYSGLVRIDRYETSPWPTDPEFRQQVFELIDVAFAQRRKT
MSMEG_5438|M.smegmatis_MC2_155 SPTVFWPIPRVYSGLVRIDRYETSPWPMDEAFRDEVFNLIDIGFAQRRKT
MLBr_00241|M.leprae_Br4923 SPTVFWPIPRVYSGLVRVDRYATSPWPTDDAFRRQVFELVDIAFTQRRKT
MAV_1148|M.avium_104 SPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFQLVDIAFGQRRKT
MMAR_4478|M.marinum_M SPTVFWPIPRVYSGLVRIDRYETTPWPTDENFRRQVFELVDIAFAQRRKT
MUL_4650|M.ulcerans_Agy99 SPTVFWPIPRVYSGLVRIDRHETTPWPTDENFRRQVFELVDIAFAQRRKT
TH_1247|M.thermoresistible__bu STWDLRPFTEDSEFLVALLRRA----------------------------
. : .. . :: : *
Rv1988|M.tuberculosis_H37Rv --------------------------------------------------
Mb2010|M.bovis_AF2122/97 --------------------------------------------------
MAB_2297|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1933|M.gilvum_PYR-GCK SRNAFAEWAGSGNESASRLLAASIDPSRRGETLSINDFVRLLQRSADWHT
Mvan_4800|M.vanbaalenii_PYR-1 SRNAFAEWAGSGNESASRLLAASIDPSRRGETLSINDFVRLLQRSADWHV
MSMEG_5438|M.smegmatis_MC2_155 SRNAFAEWAGGGNESAERLLAARIDPARRGETLSINDFVRLLQRTKEALG
MLBr_00241|M.leprae_Br4923 SRNAFVKWAGSSNESANRLLAASIDPARRGETLSIDDFVRLLRRSDGR--
MAV_1148|M.avium_104 CRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSADRGG
MMAR_4478|M.marinum_M SRNAFLEWAGSGNESANRLLAASIDPARRGETLSIEDFVRLLTRSADTSG
MUL_4650|M.ulcerans_Agy99 SRNAFLEWAGSGNESANRLLAASIDPARRGETLSIEDFVRLLTRSADTSG
TH_1247|M.thermoresistible__bu --------------------------------------------------
Rv1988|M.tuberculosis_H37Rv -------------------------
Mb2010|M.bovis_AF2122/97 -------------------------
MAB_2297|M.abscessus_ATCC_1997 -------------------------
Mflv_1933|M.gilvum_PYR-GCK VPKADDAGDDADAQAKADGAQVSTL
Mvan_4800|M.vanbaalenii_PYR-1 VPKPESA---ATAVATDEDAQVPTL
MSMEG_5438|M.smegmatis_MC2_155 EDYTKQV---ARPSASAPSVSAEA-
MLBr_00241|M.leprae_Br4923 --DDAAV---RSASAS---------
MAV_1148|M.avium_104 -SDREGT---SPPTAGQGAPAC---
MMAR_4478|M.marinum_M GPPDAGV---AGDEGQVPGPVSAT-
MUL_4650|M.ulcerans_Agy99 GPPDAGV---AGDEGQVPGPVSAT-
TH_1247|M.thermoresistible__bu -------------------------