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M. thermoresistible (build 8) TH_0980 (ksgA)

annotation: PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase)
coordinates: 1957158 - 1957931
length: 258

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_0980 ksgA - 100% (258) PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1037 ksgA 1e-109 78.23% (248) dimethyladenosine transferase
M. gilvum PYR-GCK Mflv_1933 ksgA 1e-117 84.68% (248) dimethyladenosine transferase
M. tuberculosis H37Rv Rv1010 ksgA 1e-109 78.23% (248) dimethyladenosine transferase
M. leprae Br4923 MLBr_00241 ksgA 1e-105 75.50% (249) dimethyladenosine transferase
M. abscessus ATCC 19977 MAB_1131 ksgA 1e-104 71.77% (248) dimethyladenosine transferase
M. marinum M MMAR_4478 ksgA 1e-107 76.98% (252) dimethyladenosine transferase KsgA
M. avium 104 MAV_1148 ksgA 1e-110 79.44% (248) dimethyladenosine transferase
M. smegmatis MC2 155 MSMEG_5438 ksgA 1e-120 86.40% (250) dimethyladenosine transferase
M. ulcerans Agy99 MUL_4650 ksgA 1e-106 76.19% (252) dimethyladenosine transferase
M. vanbaalenii PYR-1 Mvan_4800 ksgA 1e-117 84.68% (248) dimethyladenosine transferase

CLUSTAL 2.0.9 multiple sequence alignment


TH_0980|M.thermoresistible__bu      --------------------------------------------------
MSMEG_5438|M.smegmatis_MC2_155      ---------------------------MAKEIDFRPRKAFGQNFVHDANT
Mflv_1933|M.gilvum_PYR-GCK          --------------MTIRLLGRTEIRHLAKSIDFRPRKSFGQNFVHDANT
Mvan_4800|M.vanbaalenii_PYR-1       --------------MTIRLLGRTEIRHLAKSIDFRPRKSFGQNFVHDANT
Mb1037|M.bovis_AF2122/97            ------MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANT
Rv1010|M.tuberculosis_H37Rv         ------MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANT
MLBr_00241|M.leprae_Br4923          ------MQRKSGCTLTIRLLERTEIRWLVKELECRPRKSLGQNFVHDANT
MMAR_4478|M.marinum_M               --------------------------------------------------
MUL_4650|M.ulcerans_Agy99           --------------------------------------------------
MAV_1148|M.avium_104                ---MASVQRKSWCALTIRLLGRTEIRRLAKELEFRPRKSLGQNFVHDANT
MAB_1131|M.abscessus_ATCC_1997      MGRLAGMQRESWCPLTIRLLGRTEIRQLAKDLDFRPTKTLGQNFVHDANT
                                                                                      

TH_0980|M.thermoresistible__bu      VRRIVSASGINKQDHVLEVGPGLGSLTLGLLDRGAHVTAVEIDSVLARQL
MSMEG_5438|M.smegmatis_MC2_155      VRRIVSASGVHRHDHVLEVGPGLGSLTLALLDRGARVTAVEIDPLLARQL
Mflv_1933|M.gilvum_PYR-GCK          VRRIVSASSVNRSDHVLEVGPGLGSLTLALLDRGARVTAVEIDPVLATQL
Mvan_4800|M.vanbaalenii_PYR-1       VRRIVSASSINRSDHVLEVGPGLGSLTLALLDRGAKVTAVEIDPVLANQL
Mb1037|M.bovis_AF2122/97            VRRVVAASGVSRSDLVLEVGPGLGSLTLALLDRGATVTAVEIDPLLASRL
Rv1010|M.tuberculosis_H37Rv         VRRVVAASGVSRSDLVLEVGPGLGSLTLALLDRGATVTAVEIDPLLASRL
MLBr_00241|M.leprae_Br4923          VRRVVSTSRVNRSDFVLEVGPGFGSLTLALLDCGAAVSAIEIDPVLAGRL
MMAR_4478|M.marinum_M               MRKVVTVSGITRSDQVLEVGPGLGSLTLALLERGAAVTAVEIDPVLAARL
MUL_4650|M.ulcerans_Agy99           MRKVVAVSGTTRSDQVLEVGPGLGSLTLALLERGAAVTAVEIDPVLAARL
MAV_1148|M.avium_104                VRRVVSTSGVSRSDHVLEVGPGLGSLTLALLDRGAHVTAVEIDPVLAERL
MAB_1131|M.abscessus_ATCC_1997      IRRIVSASGVGKGDHVIEVGPGLGSLTLGLLDKGAAVTAVEVDPVLARRL
                                    :*::*:.*   : * *:*****:*****.**: ** *:*:*:*.:** :*

TH_0980|M.thermoresistible__bu      PKTIADHSHSEINRLIVLNRDILDLYPQDLETQPTALVANLPYNVAVPAL
MSMEG_5438|M.smegmatis_MC2_155      PTTIADHSHSEINRLTVLNRDILTLMPGDLEEQPTALVANLPYNVAVPAL
Mflv_1933|M.gilvum_PYR-GCK          PTTIAAHSHSEVNRLTVLNRDILTFKQSDMTEMPTALVANLPYNVAVPAL
Mvan_4800|M.vanbaalenii_PYR-1       PTTIAAHSHSEVNRLTVLNRDILTFKQSDMTEMPTALVANLPYNVAVPAL
Mb1037|M.bovis_AF2122/97            QQTVAEHSHSEVHRLTVVNRDVLALRREDLAAAPTAVVANLPYNVAVPAL
Rv1010|M.tuberculosis_H37Rv         QQTVAEHSHSEVHRLTVVNRDVLALRREDLAAAPTAVVANLPYNVAVPAL
MLBr_00241|M.leprae_Br4923          PQTVAEHSNNEIHRLTVCNRDVLSFRRGDLATEPTALVANLPYNVAVPAL
MMAR_4478|M.marinum_M               PQTVAEHSDSEIGRLTVVHHDILTLRRQDVADQPTAVVANLPYNVAVPAL
MUL_4650|M.ulcerans_Agy99           PQTVAEHSDSEIGRLTVVHHDILTLRRQDVADQPTAVVANLPYNVAVPAL
MAV_1148|M.avium_104                PHTVAEHSHSEIQRLTVLNRDVLTLRRDELAEPPTAVVANLPYNVAVPAL
MAB_1131|M.abscessus_ATCC_1997      PTTIKEHSHSEFNRFSVIHQDVLNLTPADIQGEPTAMVANLPYNVAVPAL
                                      *:  **..*. *: * ::*:* :   ::   ***:*************

TH_0980|M.thermoresistible__bu      LHLLAEFPTIRTVMVMVQAEVAERLAAEPGSKEYGVPSAKVRFYGNVRRY
MSMEG_5438|M.smegmatis_MC2_155      LHLLAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFYGNVRRH
Mflv_1933|M.gilvum_PYR-GCK          LHLLAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFFGNVRRY
Mvan_4800|M.vanbaalenii_PYR-1       LHLLAEFPSIRTVMVMVQAEVAERLAAEPGGKDYGVPSAKVRFFGNVRRY
Mb1037|M.bovis_AF2122/97            LHLLVEFPSIRVVTVMVQAEVAERLAAEPGSKEYGVPSVKLRFFGRVRRC
Rv1010|M.tuberculosis_H37Rv         LHLLVEFPSIRVVTVMVQAEVAERLAAEPGSKEYGVPSVKLRFFGRVRRC
MLBr_00241|M.leprae_Br4923          LHLLAEFPSIRTVTVMVQAEVAERLAAEPGGKDYGVPSVKLSFFGRVRRC
MMAR_4478|M.marinum_M               LHLLAEFPSIRVVTVMVQAEVAERLAAEPGGKEYGVPSVKVGFYGRVRRC
MUL_4650|M.ulcerans_Agy99           LHLLAEFPSIRVVTVMVQAEVAERLAAEPGGKEYGVPSVKVGFYGRVRRC
MAV_1148|M.avium_104                LHLLAEFPSIRTVTVMVQAEVAERLAAEPGGKEYGVPSVKVRFFGRVRRC
MAB_1131|M.abscessus_ATCC_1997      LRILTEFDSVKTILVMVQSEVADRLTAEPGSRIYGVPSVKVRYFGKVKRL
                                    *::*.** :::.: ****:***:**:****.: *****.*: ::*.*:* 

TH_0980|M.thermoresistible__bu      GMVSPTVFWPIPRVYSGLVRLDRYESPKWPMDAEFRERVFELIDIAFAQR
MSMEG_5438|M.smegmatis_MC2_155      GMVSPTVFWPIPRVYSGLVRIDRYETSPWPMDEAFRDEVFNLIDIGFAQR
Mflv_1933|M.gilvum_PYR-GCK          GMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDTEFQEQVFELIDIAFAQR
Mvan_4800|M.vanbaalenii_PYR-1       GMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDPEFRQQVFELIDVAFAQR
Mb1037|M.bovis_AF2122/97            GMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDDAFRRRVFELVDIAFAQR
Rv1010|M.tuberculosis_H37Rv         GMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDDAFRRRVFELVDIAFAQR
MLBr_00241|M.leprae_Br4923          GMVSPTVFWPIPRVYSGLVRVDRYATSPWPTDDAFRRQVFELVDIAFTQR
MMAR_4478|M.marinum_M               GMVSPTVFWPIPRVYSGLVRIDRYETTPWPTDENFRRQVFELVDIAFAQR
MUL_4650|M.ulcerans_Agy99           GMVSPTVFWPIPRVYSGLVRIDRHETTPWPTDENFRRQVFELVDIAFAQR
MAV_1148|M.avium_104                GMVSPTVFWPIPRVYSGLVRIDRYPTSPWPTDPAFRRQVFQLVDIAFGQR
MAB_1131|M.abscessus_ATCC_1997      GTVSPAVFWPIPRVYSGLVRIDRHADAAWPSDAGFRKELFDLIDISFAQR
                                    * ***:**************:**:  . ** *  *: .:*:*:*:.* **

TH_0980|M.thermoresistible__bu      RKTSRNAFAQWAGSGNESARRLLAASIDPARRGETLSIADFVRLLQR---
MSMEG_5438|M.smegmatis_MC2_155      RKTSRNAFAEWAGGGNESAERLLAARIDPARRGETLSINDFVRLLQRTKE
Mflv_1933|M.gilvum_PYR-GCK          RKTSRNAFAEWAGSGNESASRLLAASIDPSRRGETLSINDFVRLLQRSAD
Mvan_4800|M.vanbaalenii_PYR-1       RKTSRNAFAEWAGSGNESASRLLAASIDPSRRGETLSINDFVRLLQRSAD
Mb1037|M.bovis_AF2122/97            RKTSRNAFVQWAGSGSESANRLLAASIDPARRGETLSIDDFVRLLRR---
Rv1010|M.tuberculosis_H37Rv         RKTSRNAFVQWAGSGSESANRLLAASIDPARRGETLSIDDFVRLLRR---
MLBr_00241|M.leprae_Br4923          RKTSRNAFVKWAGSSNESANRLLAASIDPARRGETLSIDDFVRLLRR---
MMAR_4478|M.marinum_M               RKTSRNAFLEWAGSGNESANRLLAASIDPARRGETLSIEDFVRLLTRSAD
MUL_4650|M.ulcerans_Agy99           RKTSRNAFLEWAGSGNESANRLLAASIDPARRGETLSIEDFVRLLTRSAD
MAV_1148|M.avium_104                RKTCRNAFVDWAGSGNESADRLLAASIDPARRGETLSIDDFVRLLQRSAD
MAB_1131|M.abscessus_ATCC_1997      RKTSRNAFAEWAGSGDESARRLLAASIDPARRGETLDVADFARLLER---
                                    ***.**** .***...*** ***** ***:******.: **.*** *   

TH_0980|M.thermoresistible__bu      ------TDEVAAPAEK------------
MSMEG_5438|M.smegmatis_MC2_155      ALGEDYTKQVARPSASAPSVSAEA----
Mflv_1933|M.gilvum_PYR-GCK          WHTVPKADDAGDDADAQAKADGAQVSTL
Mvan_4800|M.vanbaalenii_PYR-1       WHVVPKPESA---ATAVATDEDAQVPTL
Mb1037|M.bovis_AF2122/97            -SGGSDEATSTGRDARAPDISGHASAS-
Rv1010|M.tuberculosis_H37Rv         -SGGSDEATSTGRDARAPDISGHASAS-
MLBr_00241|M.leprae_Br4923          -SDGRDDAAVR-----------SASAS-
MMAR_4478|M.marinum_M               TSGGPPDAGVAGDEGQVP---GPVSAT-
MUL_4650|M.ulcerans_Agy99           TSGGPPDAGVAGDEGQVP---GPVSAT-
MAV_1148|M.avium_104                -RGGSDREGTSPPTAGQG-----APAC-
MAB_1131|M.abscessus_ATCC_1997      -------SAIS-----------------

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_0980	ksgA	-	100% (258)	PROBABLE DIMETHYLADENOSINE TRANSFERASE KSGA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase)