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MSRAWASGLSLVFLLVVSVTYLLVGVLHVRPLASSYPLTIQLAESGGLLPNQDVTLHGVRIGSVDSLTFT GTGVNAVVNVDGGVRVPASAVVRVSGLSPAGEQYLDFSAGSDTGPFLTAGDVITRDRTDIPVTPAQLLSH ADGVLAQVDPSKIERIKKELSLSAAGPRKLTDIVDGGVFLLATLDSVLPETVSAIKDSRTVLSAAVDVNG GIAATARNLRGTLTGINAMDGGYRTLIGQAPQVLHAADKLFDDNSDTMVQLLANLAVNARLSYVRVPALN ALFPNYRGSALEAFISTMHDYGLWVTADLYPRYACDYGTPRHPPSAADYPEPFLYTYCRDDDPAILVRGA KNAPRPAGDDTAGPPPGADLGARSDPTPPGRYTIPTPYGGPALPIEPPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1700 | - | - | 100% (399) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4511c | - | e-145 | 63.57% (398) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1005c | - | e-145 | 63.36% (393) | putative MCE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 4e-21 | 25.00% (364) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0005 | - | 1e-150 | 64.48% (397) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-21 | 26.80% (362) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 2e-23 | 25.71% (354) | putative secreted protein |
| M. marinum M | MMAR_0182 | mce6F | 1e-169 | 71.57% (394) | MCE-family protein Mce6F |
| M. avium 104 | MAV_2383 | - | 1e-153 | 66.67% (396) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1148 | - | 1e-141 | 62.66% (399) | mce related protein |
| M. thermoresistible (build 8) | TH_2636 | - | 8e-91 | 55.28% (322) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_4914 | mce6F | 1e-170 | 71.32% (394) | MCE-family protein Mce6F |
| M. vanbaalenii PYR-1 | Mvan_0964 | - | 1e-146 | 63.22% (397) | hypothetical protein Mvan_0964 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0182|M.marinum_M MTDVAP-------SLTNMRGGRHTWLSCVGLLLTLVVSVAYLLIGVLHVR
MUL_4914|M.ulcerans_Agy99 MTDVAP-------SLTNMRGGRHTWLSCVGLLLTLVVSVAYLLIGVLHVR
MAB_1700|M.abscessus_ATCC_1997 -----------------MS---RAWASGLSLVFLLVVSVTYLLVGVLHVR
MSMEG_1148|M.smegmatis_MC2_155 MINAVA---DRIVGLVRFGYRKRSWLSALGLVMTLVVATAYLFFGALQVN
TH_2636|M.thermoresistible__bu MIGAVA---DRIVALVRFGHRRRATLSTIGLILTLVVATAYLLFGALQVN
Mflv_0005|M.gilvum_PYR-GCK MINALA---DSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFVGALQVN
Mvan_0964|M.vanbaalenii_PYR-1 MIGSVA---DAVVGVARFGYRRRAWLSTAALIMTLVVASAYLFFGALQVN
MAV_2383|M.avium_104 MIRAVAGFANLVVRAVRTGHRQQVWLSVAGLVLILVVATAYLLIGALRVT
Mb0180|M.bovis_AF2122/97 -------------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP----S
MLBr_02594|M.leprae_Br4923 -------------MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP----S
Rv1971|M.tuberculosis_H37Rv --------------MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAM
: :: *:. :* .
MMAR_0182|M.marinum_M PLAS-NYALTVELGQSGGLLPNQDVALHGVQIGKVESLEISRTGVTAILR
MUL_4914|M.ulcerans_Agy99 PLAS-NYALTVELGQSGGLLPNQDVALHGVQIGKVESLEISRTGVTAILR
MAB_1700|M.abscessus_ATCC_1997 PLAS-SYPLTIQLAESGGLLPNQDVTLHGVRIGSVDSLTFTGTGVNAVVN
MSMEG_1148|M.smegmatis_MC2_155 PLDS-DYGLTVQLPESAGLLPDQDVTLRGVPIGRVERLDITPSGVNAIVK
TH_2636|M.thermoresistible__bu PFAS-SYQVTVALPESGGLLPNQAVTLRGVPVGRVERLDITPEGVNAVVD
Mflv_0005|M.gilvum_PYR-GCK PLAK-SYRVTVQLPESAGLLPNQNVTLRGVPIGRVERLDITPAGVDAVVS
Mvan_0964|M.vanbaalenii_PYR-1 PLAS-SYRVTVELPESAGLLPNQNVTMRGVPIGRVERLDITPAGVNAVVS
MAV_2383|M.avium_104 PFAS-SYRVTVQLPESGGLLPNQDVALRGVRIGRIESLQITDNGVNAVAA
Mb0180|M.bovis_AF2122/97 LVGIGQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMS
MLBr_02594|M.leprae_Br4923 LVGIGRYSLKAELSATGGLYPTANVTYRGIAIGKVTDVEPTATGAEATMS
Rv1971|M.tuberculosis_H37Rv LFGVGRYTVTMELVEAGGLYRTGNVTYRGFEVGRVAAVRLTDTGVQAVLA
. * :. * :.** *: :*. :* : : : *. .
MMAR_0182|M.marinum_M INAGVRIPVASTVRVSALSPAGEQYVDFN--ATSGEGPFLKNGDAISQDR
MUL_4914|M.ulcerans_Agy99 INAGVRIPVASTVRVSALSPAGEQYVDFN--ATSGEGPFLKNGDAISQDR
MAB_1700|M.abscessus_ATCC_1997 VDGGVRVPASAVVRVSGLSPAGEQYLDFS--AGSDTGPFLTAGDVITRDR
MSMEG_1148|M.smegmatis_MC2_155 VKSTVRIPEASDVRVSGLSPAGEQYIDFIDVPAEDSSRFLADGAVIRQGQ
TH_2636|M.thermoresistible__bu IDSAVKIPDSSAVRVSGLSPAGEQYIDFI--PEEDTGRYLADGAHIGQGT
Mflv_0005|M.gilvum_PYR-GCK MDSSVAVPMSSAVRVSGLSPAGEQYIDFV--ADSDAGPYLENGSVIAQDN
Mvan_0964|M.vanbaalenii_PYR-1 VDSSAAVPVASSVRVSGLSPAGEQYIDFV--ADSGDGPYLADGAVVSQDN
MAV_2383|M.avium_104 ITSKVRIPANTVAHVSALSPAGEQFINFE--AASDAGPYLHDGSFITSER
Mb0180|M.bovis_AF2122/97 IASNYKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQTITKG-
MLBr_02594|M.leprae_Br4923 IDSRYKIPIDSAANVHSVSAVGEQYLDLVS--SGNPGKYLAPGQTITKS-
Rv1971|M.tuberculosis_H37Rv LKSGIDIPSDLKAEVHSHTAIGETYVELLP--RNAASPPLKNGDVIALAD
: . :* ..* . :. ** :::: . : * :
MMAR_0182|M.marinum_M TTTPVTPAELLQHADGVLAQIDPAKLAGIRRELNLSKAAP-EKLTAIVDG
MUL_4914|M.ulcerans_Agy99 TTTPVTPAELLQHADGVLAQIDPAKLAGIRRELNLSKAAP-EKLTAIVDG
MAB_1700|M.abscessus_ATCC_1997 TDIPVTPAQLLSHADGVLAQVDPSKIERIKKELSLSAAGP-RKLTDIVDG
MSMEG_1148|M.smegmatis_MC2_155 ATVPVSLADLLADADGALGQVDTAKIELIKRELSLTDAGP-QKLADIVDG
TH_2636|M.thermoresistible__bu ATVPVPLAELLADADGALAQADVEKLEIIRRELSLSPAGP-QKLKDIVDG
Mflv_0005|M.gilvum_PYR-GCK TTVPVSLADLLANADGALSQVDPGKLEVIKHELSMTEAGP-QKLADIIDG
Mvan_0964|M.vanbaalenii_PYR-1 TVVPVSLADLLANADGALAQADPAKLELIKRELSMSEAGP-QKLADIIDG
MAV_2383|M.avium_104 TTVPVSLAQLLGDADGLLAQVDPRKIELIKKELSLSKEGP-AKLTAIVDG
Mb0180|M.bovis_AF2122/97 -TVPSEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDS
MLBr_02594|M.leprae_Br4923 -KIPIEIGPALDSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSS
Rv1971|M.tuberculosis_H37Rv TSVPPDINDLLSAANTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKG
* * : * :: : * : . * ::..
MMAR_0182|M.marinum_M GVFLISTLDSVLPQTVSLLRNSRVVLSAAIDVNDGIDATARNVHQLLTGI
MUL_4914|M.ulcerans_Agy99 GVFLISTLDSVLPQTVSLLRNSRVVLSAAIDVNDGIDATARNVHQLLTGV
MAB_1700|M.abscessus_ATCC_1997 GVFLLATLDSVLPETVSAIKDSRTVLSAAVDVNGGIAATARNLRGTLTGI
MSMEG_1148|M.smegmatis_MC2_155 GTFLLSTLDSVLPETSSLLRTSRVVFTLMADKNPGISVASDNLTETFTGM
TH_2636|M.thermoresistible__bu GTFLLSTLDSVLPETSSLLRTSRVVFTLIDDKNAGIDVAADNLADTFDGV
Mflv_0005|M.gilvum_PYR-GCK GTFLLTTLDSVLPETSSMLRTSRVVFTLAADKNAGIEVASDNLAQTFDGV
Mvan_0964|M.vanbaalenii_PYR-1 GTFLLTTLDSVLPETSSMLRTSRVVLTLAADKNAGIEVASQNLDQVFDGV
MAV_2383|M.avium_104 GLFLLSTLDSVLPETTSIIKTSRVVLNLASDKNNGLGAAATELNHTLTGV
Mb0180|M.bovis_AF2122/97 TQAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQT
MLBr_02594|M.leprae_Br4923 TQAIVDAFKTNITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQS
Rv1971|M.tuberculosis_H37Rv SAELAIDARANLDPLVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQL
: : : : : :: . . : ::
MMAR_0182|M.marinum_M SSMDDGYRRMVDQTPGVLKAADNLFSDNSDTMVQLLGNLTTVAKLSYLRV
MUL_4914|M.ulcerans_Agy99 SSMDDGYRRMVDQTPGVLEAADNLFSDNSDTMVQLLGNLTTVAKLSYLRV
MAB_1700|M.abscessus_ATCC_1997 NAMDGGYRTLIGQAPQVLHAADKLFDDNSDTMVQLLANLAVNARLSYVRV
MSMEG_1148|M.smegmatis_MC2_155 DKMREGYRRLTNQTPETLAAVDNLFVDNSDTMVQLLGNLTTASRLLYLRV
TH_2636|M.thermoresistible__bu NRMREGYRRLTDQTPEVLAHVDNLFADNSDTMVQLLGNLTTTSRLLYLRV
Mflv_0005|M.gilvum_PYR-GCK NRMRDGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLGNLTTTSQLLYLRV
Mvan_0964|M.vanbaalenii_PYR-1 NRMRQGFRTLTEQTPETLAEVDNLFADNSETMVQLLGSLTSTSQLLYLRV
MAV_2383|M.avium_104 ARMQAGYRRLTSQTPQTLSAVDNLFADNSDTMVQLLGSMATMSQLLYLRV
Mb0180|M.bovis_AF2122/97 ATRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYH
MLBr_02594|M.leprae_Br4923 ARQDQHLKSILSQAAPTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYH
Rv1971|M.tuberculosis_H37Rv QTHDSAVGDLIDRGGPALGETRQLLERLQPTVPILLANLVSVGQVALTYH
: : . . :: :: *..: :
MMAR_0182|M.marinum_M PALKALFPDYRGSALEAFMSTMHDGG-----------LWATADLYPRYTC
MUL_4914|M.ulcerans_Agy99 PALKALFPDYRGSALEAFMSTMHDGG-----------LWATADLYPRYTC
MAB_1700|M.abscessus_ATCC_1997 PALNALFPNYRGSALEAFISTMHDYG-----------LWVTADLYPRYAC
MSMEG_1148|M.smegmatis_MC2_155 PALNALFPSYRTSVLDALGTAIHDGG-----------LWGTAEPYPRYTC
TH_2636|M.thermoresistible__bu PALNALFPSHRTSVLDALGAAMHDGG-----------LWGXXXP-PTICC
Mflv_0005|M.gilvum_PYR-GCK PALHALFPDYRTSVLDAIGSAMHDNG-----------LWATGEIYPRYTC
Mvan_0964|M.vanbaalenii_PYR-1 PALNALFPAHRTSVLDAIGSIMHDNG-----------LWATGDIYPRYSC
MAV_2383|M.avium_104 PALNALFPDYRGSVLDAVTSVFHDHG-----------VWATADLYPRYVC
Mb0180|M.bovis_AF2122/97 AGVEQLLVFLPQGAAIAQTVLTPTPG------AAQLPLAPAINYPPPCLT
MLBr_02594|M.leprae_Br4923 HGVEQMLVFLPQGASIAQTASATFPN------MAALDLALSINQPPPCLT
Rv1971|M.tuberculosis_H37Rv NDIEQLLVVFPMAIAAEQAGILANLNTKQAYRGQYLSFNLNLNLPPPCTT
:. :: . . . *
MMAR_0182|M.marinum_M DYGTP---SHPPSAADYPEPFLYTYCRD--DDPAVLIRGARNAPRPPGDD
MUL_4914|M.ulcerans_Agy99 DYGTP---SHPPSAADYPEPFLYTYCRD--DDPAVLIRGARNAPRPPGDD
MAB_1700|M.abscessus_ATCC_1997 DYGTP---RHPPSAADYPEPFLYTYCRD--DDPAILVRGAKNAPRPAGDD
MSMEG_1148|M.smegmatis_MC2_155 DYGTP---KLPPSSADFPEPFMYTYCRD--VHPGVLVRGAKNAPRPADDD
TH_2636|M.thermoresistible__bu NARRT---RPPPI-------------------------------------
Mflv_0005|M.gilvum_PYR-GCK DYGTP---RRPPSSADFPEPFMYNYCRD--DHPGVLVRGAKNAPRPAGDD
Mvan_0964|M.vanbaalenii_PYR-1 DYGTP---RLPPSSADYPEAFMYTYCRD--DHPGVLVRGAKNAPRPAGDD
MAV_2383|M.avium_104 DYGTP---AHASSAADYYEPFMYTYCRD--DDPAVSIRGAKNAPRPGGDD
Mb0180|M.bovis_AF2122/97 GFLPASEWRSPADTSPRPLPSG-TYCKIPQDAQLQ-VRGARNIPCVDVPG
MLBr_02594|M.leprae_Br4923 GFIPAAEWRSPADTSLQPLPVG-TYCKIPMDTPANSVRGSRNIPCVDVPG
Rv1971|M.tuberculosis_H37Rv GFLPAQQRRIPTFEDYPDRPAGDLYCRVPQDSPFN-VRGARNIPCETVPG
. . ..
MMAR_0182|M.marinum_M TAGPPPG-ADLGATTGPTPQGRFTIPTPYGGPRLPIEPPH----------
MUL_4914|M.ulcerans_Agy99 TAGPPPG-ADLGATTGPTPQGRFTIPTPYGGPRLPIEPPH----------
MAB_1700|M.abscessus_ATCC_1997 TAGPPPG-ADLGARSDPTPPGRYTIPTPYGGPALPIEPPR----------
MSMEG_1148|M.smegmatis_MC2_155 TAGPPPG-ADLGRQTDPTPRGRYTIPTPYGGPTLPIEPPR----------
TH_2636|M.thermoresistible__bu --------------------------------------------------
Mflv_0005|M.gilvum_PYR-GCK TAGPPPG-ADLGRQTDPTPRGRYTIPTPYGGPTLPIEPPR----------
Mvan_0964|M.vanbaalenii_PYR-1 TAGPPAG-ADLGRTTDPTPKGRYTIPTPYGGPTLPIEPPR----------
MAV_2383|M.avium_104 TAGPPPG-ADLGRRTDPTPRGRYTIPTPYGGPQLPIEPPH----------
Mb0180|M.bovis_AF2122/97 KRAATPKECRSKDPYVPLGTNP-WFGDPNQILTCPAPGARCDQPVKPGLV
MLBr_02594|M.leprae_Br4923 KRAASPRECRDSKPYVPLGTNP-WFGDPNQLLTCPAPGARCDQPVKPGLV
Rv1971|M.tuberculosis_H37Rv KRAPTVKLCESDAPYLPLNDGYNWKGDPN--ATVPGLGS--------GQD
MMAR_0182|M.marinum_M --------------------------------------------------
MUL_4914|M.ulcerans_Agy99 --------------------------------------------------
MAB_1700|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1148|M.smegmatis_MC2_155 --------------------------------------------------
TH_2636|M.thermoresistible__bu --------------------------------------------------
Mflv_0005|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2383|M.avium_104 --------------------------------------------------
Mb0180|M.bovis_AF2122/97 IPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYT
MLBr_02594|M.leprae_Br4923 IPAPTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYT
Rv1971|M.tuberculosis_H37Rv IPQT----------------------------------------------
MMAR_0182|M.marinum_M ----------------------------------------------
MUL_4914|M.ulcerans_Agy99 ----------------------------------------------
MAB_1700|M.abscessus_ATCC_1997 ----------------------------------------------
MSMEG_1148|M.smegmatis_MC2_155 ----------------------------------------------
TH_2636|M.thermoresistible__bu ----------------------------------------------
Mflv_0005|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 ----------------------------------------------
MAV_2383|M.avium_104 ----------------------------------------------
Mb0180|M.bovis_AF2122/97 PTSGPSAVYSPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS-
MLBr_02594|M.leprae_Br4923 PSGPPSAVYSPQSGELVGPDGVAYAVENSTKTGDDGWKEMLAPAG-
Rv1971|M.tuberculosis_H37Rv ------------------------------------WQTMLLPPGS