For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTDVAPSLTNMRGGRHTWLSCVGLLLTLVVSVAYLLIGVLHVRPLASNYALTVELGQSGGLLPNQDVALH GVQIGKVESLEISRTGVTAILRINAGVRIPVASTVRVSALSPAGEQYVDFNATSGEGPFLKNGDAISQDR TTTPVTPAELLQHADGVLAQIDPAKLAGIRRELNLSKAAPEKLTAIVDGGVFLISTLDSVLPQTVSLLRN SRVVLSAAIDVNDGIDATARNVHQLLTGISSMDDGYRRMVDQTPGVLKAADNLFSDNSDTMVQLLGNLTT VAKLSYLRVPALKALFPDYRGSALEAFMSTMHDGGLWATADLYPRYTCDYGTPSHPPSAADYPEPFLYTY CRDDDPAVLIRGARNAPRPPGDDTAGPPPGADLGATTGPTPQGRFTIPTPYGGPRLPIEPPH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0182 | mce6F | - | 100% (412) | MCE-family protein Mce6F |
| M. marinum M | MMAR_3869 | mce5F | e-150 | 64.57% (398) | Mce family protein Mce5F |
| M. marinum M | MMAR_4056 | mce3F_1 | 1e-29 | 26.98% (378) | MCE-family protein Mce3F_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 8e-25 | 25.85% (414) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0005 | - | 1e-149 | 62.44% (394) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 6e-24 | 25.56% (360) | MCE-family protein MCE1F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 2e-23 | 24.88% (406) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1700 | - | 1e-169 | 71.57% (394) | putative Mce family protein |
| M. avium 104 | MAV_2383 | - | 1e-154 | 65.08% (398) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1148 | - | 1e-143 | 62.41% (399) | mce related protein |
| M. thermoresistible (build 8) | TH_2636 | - | 2e-94 | 56.97% (323) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_4914 | mce6F | 0.0 | 99.51% (412) | MCE-family protein Mce6F |
| M. vanbaalenii PYR-1 | Mvan_0964 | - | 1e-148 | 62.47% (397) | hypothetical protein Mvan_0964 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0182|M.marinum_M MTDVAP-------SLTNMRGGRHTWLSCVGLLLTLVVSVAYLLIGVLHVR
MUL_4914|M.ulcerans_Agy99 MTDVAP-------SLTNMRGGRHTWLSCVGLLLTLVVSVAYLLIGVLHVR
MAB_1700|M.abscessus_ATCC_1997 -----------------MS---RAWASGLSLVFLLVVSVTYLLVGVLHVR
Mflv_0005|M.gilvum_PYR-GCK MINALA---DSVVRVVRTVHRGRAWLSAGALVFILVVAAAYLFVGALQVN
Mvan_0964|M.vanbaalenii_PYR-1 MIGSVA---DAVVGVARFGYRRRAWLSTAALIMTLVVASAYLFFGALQVN
MSMEG_1148|M.smegmatis_MC2_155 MINAVA---DRIVGLVRFGYRKRSWLSALGLVMTLVVATAYLFFGALQVN
TH_2636|M.thermoresistible__bu MIGAVA---DRIVALVRFGHRRRATLSTIGLILTLVVATAYLLFGALQVN
MAV_2383|M.avium_104 MIRAVAGFANLVVRAVRTGHRQQVWLSVAGLVLILVVATAYLLIGALRVT
Mb0180|M.bovis_AF2122/97 -------------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVG-
Rv0174|M.tuberculosis_H37Rv -------------MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVG-
MLBr_02594|M.leprae_Br4923 -------------MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVG-
: :: *:. ** . *
MMAR_0182|M.marinum_M PLASNYALTVELGQSGGLLPNQDVALHGVQIGKVESLEISRTGVTAILRI
MUL_4914|M.ulcerans_Agy99 PLASNYALTVELGQSGGLLPNQDVALHGVQIGKVESLEISRTGVTAILRI
MAB_1700|M.abscessus_ATCC_1997 PLASSYPLTIQLAESGGLLPNQDVTLHGVRIGSVDSLTFTGTGVNAVVNV
Mflv_0005|M.gilvum_PYR-GCK PLAKSYRVTVQLPESAGLLPNQNVTLRGVPIGRVERLDITPAGVDAVVSM
Mvan_0964|M.vanbaalenii_PYR-1 PLASSYRVTVELPESAGLLPNQNVTMRGVPIGRVERLDITPAGVNAVVSV
MSMEG_1148|M.smegmatis_MC2_155 PLDSDYGLTVQLPESAGLLPDQDVTLRGVPIGRVERLDITPSGVNAIVKV
TH_2636|M.thermoresistible__bu PFASSYQVTVALPESGGLLPNQAVTLRGVPVGRVERLDITPEGVNAVVDI
MAV_2383|M.avium_104 PFASSYRVTVQLPESGGLLPNQDVALRGVRIGRIESLQITDNGVNAVAAI
Mb0180|M.bovis_AF2122/97 --IGQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSI
Rv0174|M.tuberculosis_H37Rv --IGQYTLKADLPASGGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSI
MLBr_02594|M.leprae_Br4923 --IGRYSLKAELSATGGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSI
* :. * :.** * *: :*: :* : : : *. . :
MMAR_0182|M.marinum_M NAGVRIPVASTVRVSALSPAGEQYVDFN--ATSGEGPFLKNGDAISQDRT
MUL_4914|M.ulcerans_Agy99 NAGVRIPVASTVRVSALSPAGEQYVDFN--ATSGEGPFLKNGDAISQDRT
MAB_1700|M.abscessus_ATCC_1997 DGGVRVPASAVVRVSGLSPAGEQYLDFS--AGSDTGPFLTAGDVITRDRT
Mflv_0005|M.gilvum_PYR-GCK DSSVAVPMSSAVRVSGLSPAGEQYIDFV--ADSDAGPYLENGSVIAQDNT
Mvan_0964|M.vanbaalenii_PYR-1 DSSAAVPVASSVRVSGLSPAGEQYIDFV--ADSGDGPYLADGAVVSQDNT
MSMEG_1148|M.smegmatis_MC2_155 KSTVRIPEASDVRVSGLSPAGEQYIDFIDVPAEDSSRFLADGAVIRQGQA
TH_2636|M.thermoresistible__bu DSAVKIPDSSAVRVSGLSPAGEQYIDFI--PEEDTGRYLADGAHIGQGTA
MAV_2383|M.avium_104 TSKVRIPANTVAHVSALSPAGEQFINFE--AASDAGPYLHDGSFITSERT
Mb0180|M.bovis_AF2122/97 ASNYKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQTITKG--
Rv0174|M.tuberculosis_H37Rv ASNYKIPVDASANVHSVSAVGEQYIDLVS--TGAPGKYFSSGQTITKG--
MLBr_02594|M.leprae_Br4923 DSRYKIPIDSAANVHSVSAVGEQYLDLVS--SGNPGKYLAPGQTITKS--
. :* : ..* .:*..***:::: . :: * :
MMAR_0182|M.marinum_M TTPVTPAELLQHADGVLAQIDPAKLAGIRRELNLSKAAP-EKLTAIVDGG
MUL_4914|M.ulcerans_Agy99 TTPVTPAELLQHADGVLAQIDPAKLAGIRRELNLSKAAP-EKLTAIVDGG
MAB_1700|M.abscessus_ATCC_1997 DIPVTPAQLLSHADGVLAQVDPSKIERIKKELSLSAAGP-RKLTDIVDGG
Mflv_0005|M.gilvum_PYR-GCK TVPVSLADLLANADGALSQVDPGKLEVIKHELSMTEAGP-QKLADIIDGG
Mvan_0964|M.vanbaalenii_PYR-1 VVPVSLADLLANADGALAQADPAKLELIKRELSMSEAGP-QKLADIIDGG
MSMEG_1148|M.smegmatis_MC2_155 TVPVSLADLLADADGALGQVDTAKIELIKRELSLTDAGP-QKLADIVDGG
TH_2636|M.thermoresistible__bu TVPVPLAELLADADGALAQADVEKLEIIRRELSLSPAGP-QKLKDIVDGG
MAV_2383|M.avium_104 TVPVSLAQLLGDADGLLAQVDPRKIELIKKELSLSKEGP-AKLTAIVDGG
Mb0180|M.bovis_AF2122/97 TVPSEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDST
Rv0174|M.tuberculosis_H37Rv TVPSEIGPALDNSNRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDST
MLBr_02594|M.leprae_Br4923 KIPIEIGPALDSVNRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSST
* . * : *. *: : * : . * ::..
MMAR_0182|M.marinum_M VFLISTLDSVLPQTVSLLRNSRVVLSAAIDVNDGIDATARNVHQLLTGIS
MUL_4914|M.ulcerans_Agy99 VFLISTLDSVLPQTVSLLRNSRVVLSAAIDVNDGIDATARNVHQLLTGVS
MAB_1700|M.abscessus_ATCC_1997 VFLLATLDSVLPETVSAIKDSRTVLSAAVDVNGGIAATARNLRGTLTGIN
Mflv_0005|M.gilvum_PYR-GCK TFLLTTLDSVLPETSSMLRTSRVVFTLAADKNAGIEVASDNLAQTFDGVN
Mvan_0964|M.vanbaalenii_PYR-1 TFLLTTLDSVLPETSSMLRTSRVVLTLAADKNAGIEVASQNLDQVFDGVN
MSMEG_1148|M.smegmatis_MC2_155 TFLLSTLDSVLPETSSLLRTSRVVFTLMADKNPGISVASDNLTETFTGMD
TH_2636|M.thermoresistible__bu TFLLSTLDSVLPETSSLLRTSRVVFTLIDDKNAGIDVAADNLADTFDGVN
MAV_2383|M.avium_104 LFLLSTLDSVLPETTSIIKTSRVVLNLASDKNNGLGAAATELNHTLTGVA
Mb0180|M.bovis_AF2122/97 QAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTA
Rv0174|M.tuberculosis_H37Rv QAIVGDFKTNIGDVNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTA
MLBr_02594|M.leprae_Br4923 QAIVDAFKTNITDVNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSA
:: :.: : :. . :. * :: . . : ::
MMAR_0182|M.marinum_M SMDDGYRRMVDQTPGVLKAADNLFSDNSDTMVQLLGNLTTVAKLSY----
MUL_4914|M.ulcerans_Agy99 SMDDGYRRMVDQTPGVLEAADNLFSDNSDTMVQLLGNLTTVAKLSY----
MAB_1700|M.abscessus_ATCC_1997 AMDGGYRTLIGQAPQVLHAADKLFDDNSDTMVQLLANLAVNARLSY----
Mflv_0005|M.gilvum_PYR-GCK RMRDGFRRLTDRAPGTLNSVDNLFADNSDTMVQLLGNLTTTSQLLY----
Mvan_0964|M.vanbaalenii_PYR-1 RMRQGFRTLTEQTPETLAEVDNLFADNSETMVQLLGSLTSTSQLLY----
MSMEG_1148|M.smegmatis_MC2_155 KMREGYRRLTNQTPETLAAVDNLFVDNSDTMVQLLGNLTTASRLLY----
TH_2636|M.thermoresistible__bu RMREGYRRLTDQTPEVLAHVDNLFADNSDTMVQLLGNLTTTSRLLY----
MAV_2383|M.avium_104 RMQAGYRRLTSQTPQTLSAVDNLFADNSDTMVQLLGSMATMSQLLY----
Mb0180|M.bovis_AF2122/97 TRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHA
Rv0174|M.tuberculosis_H37Rv TRDQNVRSILSQAAPTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHA
MLBr_02594|M.leprae_Br4923 RQDQHLKSILSQAAPTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHH
: : ::. . .: :* . ::: * *..: :
MMAR_0182|M.marinum_M ------------------------------------LRVPALKALFPDYR
MUL_4914|M.ulcerans_Agy99 ------------------------------------LRVPALKALFPDYR
MAB_1700|M.abscessus_ATCC_1997 ------------------------------------VRVPALNALFPNYR
Mflv_0005|M.gilvum_PYR-GCK ------------------------------------LRVPALHALFPDYR
Mvan_0964|M.vanbaalenii_PYR-1 ------------------------------------LRVPALNALFPAHR
MSMEG_1148|M.smegmatis_MC2_155 ------------------------------------LRVPALNALFPSYR
TH_2636|M.thermoresistible__bu ------------------------------------LRVPALNALFPSHR
MAV_2383|M.avium_104 ------------------------------------LRVPALNALFPDYR
Mb0180|M.bovis_AF2122/97 GVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASE
Rv0174|M.tuberculosis_H37Rv GVEQLLVFLPQGAAIAQTVLTPTPGAAQLPLAPAINYPPPCLTGFLPASE
MLBr_02594|M.leprae_Br4923 GVEQMLVFLPQGASIAQTASATFPNMAALDLALSINQPPPCLTGFIPAAE
*.* .::* .
MMAR_0182|M.marinum_M GSALEAFMSTMHDGGLWATADLYPRYTCDYGTPSHPPSAADYPEPFLYTY
MUL_4914|M.ulcerans_Agy99 GSALEAFMSTMHDGGLWATADLYPRYTCDYGTPSHPPSAADYPEPFLYTY
MAB_1700|M.abscessus_ATCC_1997 GSALEAFISTMHDYGLWVTADLYPRYACDYGTPRHPPSAADYPEPFLYTY
Mflv_0005|M.gilvum_PYR-GCK TSVLDAIGSAMHDNGLWATGEIYPRYTCDYGTPRRPPSSADFPEPFMYNY
Mvan_0964|M.vanbaalenii_PYR-1 TSVLDAIGSIMHDNGLWATGDIYPRYSCDYGTPRLPPSSADYPEAFMYTY
MSMEG_1148|M.smegmatis_MC2_155 TSVLDALGTAIHDGGLWGTAEPYPRYTCDYGTPKLPPSSADFPEPFMYTY
TH_2636|M.thermoresistible__bu TSVLDALGAAMHDGGLWGXXXP-PTICCNARRTRPPPI------------
MAV_2383|M.avium_104 GSVLDAVTSVFHDHGVWATADLYPRYVCDYGTPAHASSAADYYEPFMYTY
Mb0180|M.bovis_AF2122/97 WRSPADTSPRPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKE
Rv0174|M.tuberculosis_H37Rv WRSPADTSPRPLPSGTYCKIPQDAQLQ-VRGARNIPCVDVLGKRAATPKE
MLBr_02594|M.leprae_Br4923 WRSPADTSLQPLPVGTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRE
* : . .
MMAR_0182|M.marinum_M CRDDDPAVLIRG----------------ARNAPRPPGDDTAGPPPGADLG
MUL_4914|M.ulcerans_Agy99 CRDDDPAVLIRG----------------ARNAPRPPGDDTAGPPPGADLG
MAB_1700|M.abscessus_ATCC_1997 CRDDDPAILVRG----------------AKNAPRPAGDDTAGPPPGADLG
Mflv_0005|M.gilvum_PYR-GCK CRDDHPGVLVRG----------------AKNAPRPAGDDTAGPPPGADLG
Mvan_0964|M.vanbaalenii_PYR-1 CRDDHPGVLVRG----------------AKNAPRPAGDDTAGPPAGADLG
MSMEG_1148|M.smegmatis_MC2_155 CRDVHPGVLVRG----------------AKNAPRPADDDTAGPPPGADLG
TH_2636|M.thermoresistible__bu --------------------------------------------------
MAV_2383|M.avium_104 CRDDDPAVSIRG----------------AKNAPRPGGDDTAGPPPGADLG
Mb0180|M.bovis_AF2122/97 CRSKDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTG
Rv0174|M.tuberculosis_H37Rv CRSKDPYVPLGTNPWFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTG
MLBr_02594|M.leprae_Br4923 CRDSKPYVPLGTNPWFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNG
MMAR_0182|M.marinum_M ATTGPTPQGRFTIP--------------------------TPYGGPRLPI
MUL_4914|M.ulcerans_Agy99 ATTGPTPQGRFTIP--------------------------TPYGGPRLPI
MAB_1700|M.abscessus_ATCC_1997 ARSDPTPPGRYTIP--------------------------TPYGGPALPI
Mflv_0005|M.gilvum_PYR-GCK RQTDPTPRGRYTIP--------------------------TPYGGPTLPI
Mvan_0964|M.vanbaalenii_PYR-1 RTTDPTPKGRYTIP--------------------------TPYGGPTLPI
MSMEG_1148|M.smegmatis_MC2_155 RQTDPTPRGRYTIP--------------------------TPYGGPTLPI
TH_2636|M.thermoresistible__bu --------------------------------------------------
MAV_2383|M.avium_104 RRTDPTPRGRYTIP--------------------------TPYGGPQLPI
Mb0180|M.bovis_AF2122/97 LNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTSGPSAVY
Rv0174|M.tuberculosis_H37Rv LNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTSGPSAVY
MLBr_02594|M.leprae_Br4923 LNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSGPPSAVY
MMAR_0182|M.marinum_M EPPH--------------------------------
MUL_4914|M.ulcerans_Agy99 EPPH--------------------------------
MAB_1700|M.abscessus_ATCC_1997 EPPR--------------------------------
Mflv_0005|M.gilvum_PYR-GCK EPPR--------------------------------
Mvan_0964|M.vanbaalenii_PYR-1 EPPR--------------------------------
MSMEG_1148|M.smegmatis_MC2_155 EPPR--------------------------------
TH_2636|M.thermoresistible__bu ------------------------------------
MAV_2383|M.avium_104 EPPH--------------------------------
Mb0180|M.bovis_AF2122/97 SPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
Rv0174|M.tuberculosis_H37Rv SPASGELVGPDGVKYAVANSSTTGDDGWKEMLAPAS
MLBr_02594|M.leprae_Br4923 SPQSGELVGPDGVAYAVENSTKTGDDGWKEMLAPAG