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NNNIALSSRRSCTHLGPKFHDPNTLVGNTPVLWVSEPFSGPGTGFWAKLEAHNPNGMKDRPALYMVERAR ERGDLKPGAMIVESTSGTLGLGLALAGIIYRHPVTLVTDPGLEPIIVQMLTAYGAVVDIVTEPHPIGGWQ QARKDRVAEILAAEPDSWCPDQYQNPDNVDAYRGVAEELIDQLGTVDTLVCSVGTGGHSSGVGRVLREHN PNLRLVGVDTIGSTIFGQPASTRLMRGLGSSIYPGNVDYRAFDEAHWVAPNEAVWAARTLAASYHASGGW SVGAVALVAGWVARTSEPGTRVAAIFPDGPMRYHGTIYDDDYCRSHDLLDRPPAQDPDVIDDPSQRVVDR WTRLTHVIDPLGRTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0451c | - | - | 100% (366) | cysteine synthase |
| M. abscessus ATCC 19977 | MAB_1273 | - | 0.0 | 92.62% (366) | cysteine synthase A CysK2 |
| M. abscessus ATCC 19977 | MAB_1195 | - | 1e-29 | 31.53% (314) | cystathionine beta-synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0871 | cysK2 | 1e-145 | 72.43% (341) | cysteine synthase A CysK2 |
| M. gilvum PYR-GCK | Mflv_0899 | - | 1e-147 | 70.85% (343) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
| M. tuberculosis H37Rv | Rv0848 | cysK2 | 1e-146 | 72.43% (341) | cysteine synthase A CysK2 |
| M. leprae Br4923 | MLBr_02396 | cysM2 | 3e-30 | 32.80% (311) | cystathionine beta-synthase |
| M. marinum M | MMAR_4768 | cysK2 | 1e-147 | 72.81% (342) | cysteine synthase a CysK2 |
| M. avium 104 | MAV_1201 | - | 2e-29 | 31.05% (351) | cystathionine beta-synthase |
| M. smegmatis MC2 155 | MSMEG_5270 | - | 3e-30 | 32.91% (313) | cystathionine beta-synthase |
| M. thermoresistible (build 8) | TH_1449 | cysK | 5e-35 | 34.42% (308) | PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE |
| M. ulcerans Agy99 | MUL_0203 | cbs | 2e-29 | 31.51% (311) | cystathionine beta-synthase CBS |
| M. vanbaalenii PYR-1 | Mvan_5856 | - | 1e-145 | 69.97% (343) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0871|M.bovis_AF2122/97 ---------------------------------MRSRQTRDRYRLLPEGY
Rv0848|M.tuberculosis_H37Rv ---------------------------------MRSRQTRDRYRLLPEGY
MMAR_4768|M.marinum_M MNPNLPLVNAANSAGDNLNISPTTLPGRSHLTSMRPRQTRDRYRVVPEGY
Mflv_0899|M.gilvum_PYR-GCK ---------------------------------MNHALSIHHAQDTDRFE
Mvan_5856|M.vanbaalenii_PYR-1 ---------------------------------MNHVLSIHHAQLS---E
MAB_0451c|M.abscessus_ATCC_199 ---------------------------------MNNNIALSSRRSCT---
MAV_1201|M.avium_104 --------------------------------------------------
MUL_0203|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02396|M.leprae_Br4923 --------------------------------------------------
MSMEG_5270|M.smegmatis_MC2_155 --------------------------------------------------
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mb0871|M.bovis_AF2122/97 QVTPGRNRHPGTMVGNTPVLWIP-ELSGTSDPDRGFWAKLEGFNPGG-MK
Rv0848|M.tuberculosis_H37Rv QVTPGRNRHPGTMVGNTPVLWIP-ELSGTSDPDRGFWAKLEGFNPGG-MK
MMAR_4768|M.marinum_M HPIPGRNRHPGTMVGNTPVLWVSGDASPVGSADRGFWAKLEGFNPGG-MK
Mflv_0899|M.gilvum_PYR-GCK QLRLGRYERPATMVGQTPVLRIG---APFTAAEHGFWAKLEGFNPGG-MK
Mvan_5856|M.vanbaalenii_PYR-1 QRQLGRYERPATMVGQTPVLRIT---VPFTDADRGFWAKLEGFNPGG-MK
MAB_0451c|M.abscessus_ATCC_199 HLGP-KFHDPNTLVGNTPVLWVS---EPFSGPGTGFWAKLEAHNPNG-MK
MAV_1201|M.avium_104 --MR-IAQHISDLIGGTPLVRLN---SVVPDGAGIVAAKVEYLNPGGSSK
MUL_0203|M.ulcerans_Agy99 --MR-IAQHISDLIGGTPLVRLN---AVVPAGIGTVAAKVEYLNPGGSSK
MLBr_02396|M.leprae_Br4923 --MR-IAQHISDLIGGTPLVRLN---SVVPAGTGVVAAKVEYFNSGGSSK
MSMEG_5270|M.smegmatis_MC2_155 --MR-IARHISELIGNTPLVQLN---SVVPEGAGLVAAKIEYLNPGGSSK
TH_1449|M.thermoresistible__bu --MGNIYNDVTEIVGRTPLVRLN---RLTEGLDAQVLAKLEFYNPANSVK
. ::* **:: : . **:* *. . *
Mb0871|M.bovis_AF2122/97 DRPALYMVECARARGDIAPGAAIVESTSGTLGLGLALAGKVYRHPVTLVT
Rv0848|M.tuberculosis_H37Rv DRPALYMVECARARGDIAPGAAIVESTGGTLGLGLALAGKVYRHPVTLVT
MMAR_4768|M.marinum_M DRPAMHMVERARARGELAPGAAIVESTSGTLGLGLALAGSVYGHPVTLVT
Mflv_0899|M.gilvum_PYR-GCK DRPALHMVERARSRGKLVPGARIVESTSGTLGLGLALAGTVYGHPVTLVT
Mvan_5856|M.vanbaalenii_PYR-1 DRPALHMVQRARAAGALKPGARIVESTSGTLGLGLALAGTGYGHPVTLVT
MAB_0451c|M.abscessus_ATCC_199 DRPALYMVERARERGDLKPGAMIVESTSGTLGLGLALAGIIYRHPVTLVT
MAV_1201|M.avium_104 DRIAVRMIDAAEASGALKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVC
MUL_0203|M.ulcerans_Agy99 DRIAIKMIDAAEASGALRPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVC
MLBr_02396|M.leprae_Br4923 DRIAAKMIDAAEASGQLKPGGTIVEPTSGNTGVGLALVAQHRGYKCVFVC
MSMEG_5270|M.smegmatis_MC2_155 DRIALKMIEAAEVSGELKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVC
TH_1449|M.thermoresistible__bu DRIGVAIVDAAEASGALKPGGTIVEATSGNTGIALAMVGAARGYRVILTM
** . ::: *. * : **. ***.*.*. *:.**:.. : :.
Mb0871|M.bovis_AF2122/97 DPGLEPIIARMLTAYGAGVDMGTQPHPVGGWQQARKDRVAQLMAEYPGAW
Rv0848|M.tuberculosis_H37Rv DPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARKDRVAQLMAEYPGAW
MMAR_4768|M.marinum_M DPGLEPIIARMLTAYGARVDMVTEPHPVGGWQQARKDRVAQLLAADPSAW
Mflv_0899|M.gilvum_PYR-GCK DPGMEPMIQHMLAAFGAHIELVTEPHPRGGWQQARTERVHEILGTDPQAW
Mvan_5856|M.vanbaalenii_PYR-1 DPGLEPIVARMLTAFGAHIELVVEPHQHGGWQQARRERVQQILSSDPHAW
MAB_0451c|M.abscessus_ATCC_199 DPGLEPIIVQMLTAYGAVVDIVTEPHPIGGWQQARKDRVAEILAAEPDSW
MAV_1201|M.avium_104 PDKVGEDKRNVLMAYGAEVVVCPTAVPPEHPDSYYS-VSDRLVTEIEGAW
MUL_0203|M.ulcerans_Agy99 PDKVSEDKRNVLRAYGAEVVVCPTAVPPEDPDSYYS-VSDRLVREIDGAW
MLBr_02396|M.leprae_Br4923 PDKVSEDKRNVLLAYGAEVVVCPTAVPPDDPDSYYS-VSDRLVAKIDGAW
MSMEG_5270|M.smegmatis_MC2_155 PDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYS-VSNRLVTEIEGAW
TH_1449|M.thermoresistible__bu PDTMSVERRVMLRAFGAEIVLTPGAEG---MAGAVA-RAEQILAETENAV
: :* *:** : : . .:: :
Mb0871|M.bovis_AF2122/97 NPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCSVGTGGHSAGVARVL
Rv0848|M.tuberculosis_H37Rv NPNQYGNPDNVGAYRSLA--LELVAQLGRIDVLVCSVGTGGHSAGVARVL
MMAR_4768|M.marinum_M NPDQYSNPDNVDAYRPLA--LEMAAQLGRVDVLVCSVGTGGHSSGVARVL
Mflv_0899|M.gilvum_PYR-GCK HPDQYNNPDNVEAYRGLA--MELIEQLGSVDVLVCSVGTGGHSAGVARVL
Mvan_5856|M.vanbaalenii_PYR-1 HPDQYNNPDNVEAYRGLA--HELIDQLGSVDVLVCSVGTGGHSAGVARVL
MAB_0451c|M.abscessus_ATCC_199 CPDQYQNPDNVDAYRGVA--EELIDQLGTVDTLVCSVGTGGHSSGVGRVL
MAV_1201|M.avium_104 KPDQYANPEGPASHYATTGPEIWADTDGKVTHFVAGIGTGGTITGAGRYL
MUL_0203|M.ulcerans_Agy99 KPDQYANPEGPASHYATTGPEIWADTDGKITHFVAGIGTGGTITGAGCYL
MLBr_02396|M.leprae_Br4923 KPDQYANPAGPASHYETTGPEIWADTDGRVTHFVAGIGTGGTITGVGRYL
MSMEG_5270|M.smegmatis_MC2_155 KPDQYSNQMGPESHYETTGPEIWADTEGKITHFVAGVGTGGTITGTGRYL
TH_1449|M.thermoresistible__bu AAKQFANPANPDIHERTTGEEVWADTDGTVDIFVAGIGTGGTLTGVGRLL
..*: * . : : * : :*..:**** :*.. *
Mb0871|M.bovis_AF2122/97 REFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGSSIYPRNVDYRAFDE
Rv0848|M.tuberculosis_H37Rv REFNPD-MRLIGVDTIGS-TIFGQPASNRLMRGLGSSIYPRNVDYRAFDE
MMAR_4768|M.marinum_M REFNPA-MRLIGVDTIGS-TIFGQPASSRLMRGLGSSIFPRNVDYSAFNE
Mflv_0899|M.gilvum_PYR-GCK REYNPG-LRLIGVDTVGS-TIFGQPATTRLMRGLGSSIYPGNVDYAAFNE
Mvan_5856|M.vanbaalenii_PYR-1 RETDPQ-LRLIGVDTVGS-TIFGQPAGARLMRGLGSSIYPGNVDYAAFDE
MAB_0451c|M.abscessus_ATCC_199 REHNPN-LRLVGVDTIGS-TIFGQPASTRLMRGLGSSIYPGNVDYRAFDE
MAV_1201|M.avium_104 KEVSGGRVRVIGADPEGS-VYSGGTGRPYLVEGVGEDFWPQAYDRTVPDE
MUL_0203|M.ulcerans_Agy99 KEVSGGKVRVIGADPEGS-VYSGGTGRPYLVEGVGEDFWPATYDHAVPDE
MLBr_02396|M.leprae_Br4923 KEVSGGLVRIIGADPEGS-VYSGGTGRPYLVEGVGEDFWPAAYDPMVPDQ
MSMEG_5270|M.smegmatis_MC2_155 KEVSGGKVKVIGADPEGS-VYSGGTGRPYLVEGVGEDFWPTAYDPSVPDE
TH_1449|M.thermoresistible__bu KSRKPG-VKIVGVEPLDSPILNGGQPGPHKIQGIGANFIPEVLDRDVYDE
:. . ::::*.:. .* * :.*:* .: * * . ::
Mb0871|M.bovis_AF2122/97 VHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAGWAARNLP-ADTTIA
Rv0848|M.tuberculosis_H37Rv VHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAGWAARNLP-ADTTIA
MMAR_4768|M.marinum_M VHWVAPAEAVWACRSMAATHYASGGWSVGAVALVAGWAARTLP-SDITIA
Mflv_0899|M.gilvum_PYR-GCK VHWVAPADAVWACRTLAATHYASGGWSVGAVAVVAGWAARGSD-PGTTVA
Mvan_5856|M.vanbaalenii_PYR-1 VHWVAPAEAVWACRTLAATHYASGGWSVGAVALVAGWAARNSP-PATTVA
MAB_0451c|M.abscessus_ATCC_199 AHWVAPNEAVWAARTLAASYHASGGWSVGAVALVAGWVARTSE-PGTRVA
MAV_1201|M.avium_104 IIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALRVAEQAG-PDALVV
MUL_0203|M.ulcerans_Agy99 IIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALRVAEQAG-PDALVV
MLBr_02396|M.leprae_Br4923 IIAVSDSDSFNMTRRLAREEAMLVGGSCGMAVVAALQVAEEAG-PAALVV
MSMEG_5270|M.smegmatis_MC2_155 IIAVSDADSFEMTRRLAREEALLVGGSCGMAVVAAIEVARKAG-PDAVVV
TH_1449|M.thermoresistible__bu IIDAGFEDAISVSRALATQEGILGGISAGANVWAALEVAKRPENAGKVIV
.. ::. * :* * * * . .* .*. . :.
Mb0871|M.bovis_AF2122/97 AVFPDGPQRYFDTIYNDAYCNEHELLGGQ---------------------
Rv0848|M.tuberculosis_H37Rv AVFPDGPQRYFDTIYNDAYCNEHELLGGQ---------------------
MMAR_4768|M.marinum_M AVFPDGPQRYFDTVYNDDYCNEHGLLGQR---------------------
Mflv_0899|M.gilvum_PYR-GCK AIFPDGPQRYFDTIYNDEYCRTHGLLDKA---------------------
Mvan_5856|M.vanbaalenii_PYR-1 AIFPDGPQRYFDTVYNDDYCRAHHLLGGA---------------------
MAB_0451c|M.abscessus_ATCC_199 AIFPDGPMRYHGTIYDDDYCRSHDLLDRP---------------------
MAV_1201|M.avium_104 VLLPDGGRGYMAKIFNDAWMSSYGFLRTRLDGSTDQSRVGDVLRRKSGEL
MUL_0203|M.ulcerans_Agy99 VLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGRTDTSTVGDVLRRKSGAL
MLBr_02396|M.leprae_Br4923 VLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQPIVGDVLRRKSGAL
MSMEG_5270|M.smegmatis_MC2_155 VLLPDGGRGYLSKIFNDAWMSSYGFLRTRLDGSVEKT-VGDVLRGKSGAL
TH_1449|M.thermoresistible__bu VVIPDFGERYVS--------------------------------------
.::** *
Mb0871|M.bovis_AF2122/97 ----PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVVS-------------
Rv0848|M.tuberculosis_H37Rv ----PPTEPDEIASPLDAVVTRWTRSTTVIDPTQVVS-------------
MMAR_4768|M.marinum_M ----PATEPEVIASPSAAVVQRWTRSATVIDPTQVAA-------------
Mflv_0899|M.gilvum_PYR-GCK ----PPNEPATIDHPLRHAVKAWTRCPVVVDPTQVVPR------------
Mvan_5856|M.vanbaalenii_PYR-1 ----PPSHPATIADPLAQVATAWSRCTRIVDPTRVMPR------------
MAB_0451c|M.abscessus_ATCC_199 ----PAQDPDVIDDPSQRVVDRWTRLTHVIDPLGRTA-------------
MAV_1201|M.avium_104 PDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSEREL
MUL_0203|M.ulcerans_Agy99 PALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSEREL
MLBr_02396|M.leprae_Br4923 PDLVHTHPSETVRDAIGILREYAVSQIPVVGAEPPVMAGEVVGSVSEREL
MSMEG_5270|M.smegmatis_MC2_155 PDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSEREL
TH_1449|M.thermoresistible__bu -----TALFEHIRD------------------------------------
. :
Mb0871|M.bovis_AF2122/97 --------------------------------------------------
Rv0848|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4768|M.marinum_M --------------------------------------------------
Mflv_0899|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5856|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0451c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1201|M.avium_104 LSAVFEGRAKLADAVSLHMSPPLPMIGAGESVSAAGKALRDWDALMVVEE
MUL_0203|M.ulcerans_Agy99 LSAVFSGKAKLADAVSQHMSPPLKLIGAGELVGVAGKALRDWDALMVVEE
MLBr_02396|M.leprae_Br4923 LSAVFEGRASLADAVSEHMGPPLRLIGDGELVSVAGEALRDSDALMVVEK
MSMEG_5270|M.smegmatis_MC2_155 LSAVFEGRAKLADAVAEHMSPPLPLIGAGELVSTAAKTLRESDAVMVVED
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mb0871|M.bovis_AF2122/97 ---------------------------
Rv0848|M.tuberculosis_H37Rv ---------------------------
MMAR_4768|M.marinum_M ---------------------------
Mflv_0899|M.gilvum_PYR-GCK ---------------------------
Mvan_5856|M.vanbaalenii_PYR-1 ---------------------------
MAB_0451c|M.abscessus_ATCC_199 ---------------------------
MAV_1201|M.avium_104 GKPVGVITRYDLLGFLSEGPRGSGGRR
MUL_0203|M.ulcerans_Agy99 GKPVGVITRYDLLGFLSEG----ALRR
MLBr_02396|M.leprae_Br4923 GKLVGVITRYDLLGFLSEG----APLR
MSMEG_5270|M.smegmatis_MC2_155 GKPVGVLTRHDLLGFLSEG----GYRH
TH_1449|M.thermoresistible__bu ---------------------------