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MAKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGELLGCVSGELGLRRYLEAHGHE LVVTSDKDGPDSVFEKELPDADVVISQPFWPAYLSAERIAKAPKLKLALTAGIGSDHVDLDAAIKAGITV AEVTYCNSISVAEHAVMQILALVRNYLPAHQWVVDGGWNIADSVERAYDLEGFDVGVIAAGRIGQAVLRR LKPFDVRLHYFDTRRLPAEVEHELGLTYHPDVQSLVRSVDIVDIHAPLHPQTYHLFDANLINSMRRGSYI VNTARAEITVQEDIVKALESGQLAGYAGDVWYPQPPAPDHPWRTMPHEAMTPHVSGTTLSAQARYAAGTR EILEDFFGGRSIRDEYLIVEGGQLAGTGAKSYTADGSASPGAGT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0999 | - | - | 100% (394) | formate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4334 | - | 5e-29 | 30.07% (286) | 2-hydroxyacid dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 1e-24 | 30.82% (279) | D-3-phosphoglycerate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 2e-27 | 29.86% (288) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0334 | - | 3e-28 | 30.26% (304) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 2e-27 | 29.86% (288) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 3e-28 | 30.46% (302) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 4e-29 | 30.98% (297) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. avium 104 | MAV_4930 | - | 1e-172 | 76.33% (376) | formate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2378 | serA | 4e-30 | 32.97% (273) | D-3-phosphoglycerate dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 2e-30 | 34.42% (276) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 3e-29 | 30.98% (297) | D-3-phosphoglycerate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0404 | - | 1e-27 | 30.77% (286) | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 --------------------------------------MSLPVVLIADKL
Rv2996c|M.tuberculosis_H37Rv --------------------------------------MSLPVVLIADKL
MLBr_01692|M.leprae_Br4923 --------------------------------------MDLPVVLIADKL
MMAR_1715|M.marinum_M --------------------------------------MNLPVVLIADKL
MUL_1952|M.ulcerans_Agy99 --------------------------------------MNLPVVLIADKL
MSMEG_2378|M.smegmatis_MC2_155 --------------------------------------MSLPVVLIADKL
TH_2037|M.thermoresistible__bu --------------------------------------VSLPVVLIADKL
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------MRVLAHFLPG--
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------MRVLAHFVPGGP
MAB_0999|M.abscessus_ATCC_1997 MAKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGEL
MAV_4930|M.avium_104 ----MMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGEL
: ..
Mb3020c|M.bovis_AF2122/97 APSTVAALG---------DQVEVRWVDGPDRDKLLAAVPEADALLVR--S
Rv2996c|M.tuberculosis_H37Rv APSTVAALG---------DQVEVRWVDGPDRDKLLAAVPEADALLVR--S
MLBr_01692|M.leprae_Br4923 AQSTVAALG---------DQVEVRWVDGPDRTKLLAAVPEADALLVR--S
MMAR_1715|M.marinum_M AQSTVAALG---------DQVEVRWVDGPDREKLLAAVPEADALLVR--S
MUL_1952|M.ulcerans_Agy99 AQSTVAALG---------DQVEVRWVDGPDREKLLAAVPEADALLVR--S
MSMEG_2378|M.smegmatis_MC2_155 AESTVAALG---------DEVEVRWVDGPDRAKLLAAVPEADALLVR--S
TH_2037|M.thermoresistible__bu AESTVAALG---------DQVEVRWVDGPDREKLLAAVADADALLVR--S
Mflv_0334|M.gilvum_PYR-GCK -PKVTEFLSP------HTDWLDIRYCAEDDDETFYRELPDAEVIWH---V
Mvan_0404|M.vanbaalenii_PYR-1 DSKVIEFLAP------CRDWLDVRFCAEDDDDTFYRELADAEVIWH---V
MAB_0999|M.abscessus_ATCC_1997 LGCVSGELGLRRYLEAHGHELVVTSDKDGPDSVFEKELPDADVVISQPFW
MAV_4930|M.avium_104 LGCVSGALGLRKFFEDGGHELVVTSDKDGPDSEFERELPDADIVISQPFW
. *. . : : : :.:*: :
Mb3020c|M.bovis_AF2122/97 ATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHS
Rv2996c|M.tuberculosis_H37Rv ATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHS
MLBr_01692|M.leprae_Br4923 ATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHS
MMAR_1715|M.marinum_M ATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNIHS
MUL_1952|M.ulcerans_Agy99 ATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNIHS
MSMEG_2378|M.smegmatis_MC2_155 ATTVDAEVIAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHS
TH_2037|M.thermoresistible__bu ATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAATARGVLVVNAPTSNIHS
Mflv_0334|M.gilvum_PYR-GCK LRPISGDDLSKAPKLRLVHKLGAGVNTVDVDTATARGIAVANMPGANAPS
Mvan_0404|M.vanbaalenii_PYR-1 LRPLSGEDLARAPRLRLVHKLGAGVNTIDVDAATARGVAVANMPGANAES
MAB_0999|M.abscessus_ATCC_1997 PAYLSAERIAKAPKLKLALTAGIGSDHVDLDAAIKAGITVAEVTYCNSIS
MAV_4930|M.avium_104 PAYITKERFAKARNLKLALTAGIGSDHVDLTEAQARGVTVAEETWSNSIS
: : :: * .*::. * * : :*: * *: *.: . .* *
Mb3020c|M.bovis_AF2122/97 AAEHALALLLAASRQIPAADASLREHTWKRSSFSG----TEIFGKTVGVV
Rv2996c|M.tuberculosis_H37Rv AAEHALALLLAASRQIPAADASLREHTWKRSSFSG----TEIFGKTVGVV
MLBr_01692|M.leprae_Br4923 AAEHALALLLAASRQIAEADASLRAHIWKRSSFSG----TEIFGKTVGVV
MMAR_1715|M.marinum_M AAEHAMALLLAAARQIPAADASLREHTWKRSSFSG----AEIFGKTVGVV
MUL_1952|M.ulcerans_Agy99 AAEHAMALLLAAARQIPAADASLREHTWKRSSFSG----AEIFGKTVGVV
MSMEG_2378|M.smegmatis_MC2_155 AAEHAIALLLATARQIPAADATLRERSWKRSSFSG----TEIFGKTVGVV
TH_2037|M.thermoresistible__bu AAEHAIALLLAAARQIPAADATLRQRTWKRSEFSG----VEIYDKTVGVV
Mflv_0334|M.gilvum_PYR-GCK VAEGTLLLMLAALRRLPELDRATRTGNGWPSDPTLGESVRDLGGCTVGLV
Mvan_0404|M.vanbaalenii_PYR-1 VAEGTLLLMLAALRRLPVLDRATREGRGWPSDPTLGETVRDIGGCTVGLV
MAB_0999|M.abscessus_ATCC_1997 VAEHAVMQILALVRNYLPAHQWVVDGGWNIADSVER--AYDLEGFDVGVI
MAV_4930|M.avium_104 VAEHTVMQILALVRNFVPSHQWIRDGGWNIADCVQR--SYDVEGMDVGVI
.** :: :** *. . :. :: . **::
Mb3020c|M.bovis_AF2122/97 GLGRIGQLVAQRIAAFGAYVVAYDPY-VSPARAAQLGIELL-SLDDLLAR
Rv2996c|M.tuberculosis_H37Rv GLGRIGQLVAQRIAAFGAYVVAYDPY-VSPARAAQLGIELL-SLDDLLAR
MLBr_01692|M.leprae_Br4923 GLGRIGQLVAARIAAFGAHVIAYDPY-VAPARAAQLGIELM-SFDDLLAR
MMAR_1715|M.marinum_M GLGRIGQLVAQRVEAFGAHVVAYDPY-VSPARAAQLGIELL-PLDDLLAR
MUL_1952|M.ulcerans_Agy99 GLGRIGQLVAQRVEAFGAHVVAYDPY-VSPARAAQLGIELL-PLDDLLAR
MSMEG_2378|M.smegmatis_MC2_155 GLGRIGQLVAQRLAAFGAHIVAYDPY-VSQARAAQLGIELL-PLDDLLAR
TH_2037|M.thermoresistible__bu GLGRIGQLVAQRLAAFGTHLIAYDPY-VSPARAAQLGIELV-DLDELLGR
Mflv_0334|M.gilvum_PYR-GCK GYGNIAKQVERILLAIGAEVVHTSTR-DDGLPGWRT-------LPDLLSE
Mvan_0404|M.vanbaalenii_PYR-1 GYGNIAKQVERILVAMGADVIHTSTR-DDGSAGWRS-------LPDLLSA
MAB_0999|M.abscessus_ATCC_1997 AAGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHPDVQSLVRS
MAV_4930|M.avium_104 AAGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLGVTYHPDVESLARS
. *.*.: * : .:.. : . . . .*
Mb3020c|M.bovis_AF2122/97 ADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAI
Rv2996c|M.tuberculosis_H37Rv ADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAI
MLBr_01692|M.leprae_Br4923 ADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAV
MMAR_1715|M.marinum_M ADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAI
MUL_1952|M.ulcerans_Agy99 ADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAI
MSMEG_2378|M.smegmatis_MC2_155 ADFISVHLPKTKETAGLLGKEALAKTKKGVIIVNAARGGLIDEQALADAI
TH_2037|M.thermoresistible__bu ADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAARGGLIDEQALADAI
Mflv_0334|M.gilvum_PYR-GCK SDIVSLHLPLTGATEGLLGRKALAQMKTDAVLVNTSRGAIVDEAALVDAL
Mvan_0404|M.vanbaalenii_PYR-1 CDIVSLHLPLTDATAGLLGRDALARMKSDAVLVNTSRGPIVDEEALADAL
MAB_0999|M.abscessus_ATCC_1997 VDIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKAL
MAV_4930|M.avium_104 VDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIVAAL
*.:.:* * * ::. . : : . :**::*. . :. *:
Mb3020c|M.bovis_AF2122/97 TGGHVRAAGLDVFATEPCT-DSPLFELAQVVVTPHLGASTAEAQDRAGTD
Rv2996c|M.tuberculosis_H37Rv TGGHVRAAGLDVFATEPCT-DSPLFELAQVVVTPHLGASTAEAQDRAGTD
MLBr_01692|M.leprae_Br4923 RSGHVRAAGLDVFATEPCT-DSPLFELSQVVVTPHLGASTAEAQDRAGTD
MMAR_1715|M.marinum_M TSGHVRGAGLDVFATEPCT-DSPLFELPQVVVTPHLGASTAEAQDRAGTD
MUL_1952|M.ulcerans_Agy99 TSGYVRGAGLDVFATEPCT-DSPLFELPQVVVTPHLGASTAEAQDRAGTD
MSMEG_2378|M.smegmatis_MC2_155 TSGHVRGAGLDVYATEPCT-DSPLFDLPQVVVTPHLGASTAEAQDRAGTD
TH_2037|M.thermoresistible__bu ISGRVRAAGIDVFAKEPCT-DSPLFDLPQVVVTPHLGASTVEAQDRAGTD
Mflv_0334|M.gilvum_PYR-GCK RAGTLAAAGLDVFAVEPVPSDNPLLGLPNVVLTPHVTWYTADTMRRYLEF
Mvan_0404|M.vanbaalenii_PYR-1 RTGKLAAAGLDVFAVEPVPADNPLLRLPNVVLTPHVTWYTADTMRRYLEF
MAB_0999|M.abscessus_ATCC_1997 ESGQLAGYAGDVWYPQPPAPDHPWRTMPHEAMTPHVSGTTLSAQARYAAG
MAV_4930|M.avium_104 ESGQLAGYAGDVWFPQPPPPHHPWRTMPNHAMTPHISGSSLSAQARYCAG
* : . . **: :* . . * :.: .:***: : .: *
Mb3020c|M.bovis_AF2122/97 VAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDEL
Rv2996c|M.tuberculosis_H37Rv VAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDEL
MLBr_01692|M.leprae_Br4923 VAESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCKLGVLVAALSDEL
MMAR_1715|M.marinum_M VAASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEP
MUL_1952|M.ulcerans_Agy99 VAASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEP
MSMEG_2378|M.smegmatis_MC2_155 VAASVKLALAGEFVPDAVNVGGGVVGEEVAPWLELVRKLGLLVGALADAP
TH_2037|M.thermoresistible__bu VAASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLARKLGLLVGTLSGEP
Mflv_0334|M.gilvum_PYR-GCK ALDNCERLRDGRALAHVVNDPSG---------------------------
Mvan_0404|M.vanbaalenii_PYR-1 AVDNCERLRDGRNLVNVVNDVAG---------------------------
MAB_0999|M.abscessus_ATCC_1997 TREILEDFFGGRSIRDEYLIVEGGQ----------------LAGTGAKSY
MAV_4930|M.avium_104 TREILEDWFAGRPIRSEYLIVEGGK----------------FAGTGAKSY
. . *. : *
Mb3020c|M.bovis_AF2122/97 PVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERG
Rv2996c|M.tuberculosis_H37Rv PVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERG
MLBr_01692|M.leprae_Br4923 PASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVTFVNAPALAAERG
MMAR_1715|M.marinum_M PVSLSVQARGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERG
MUL_1952|M.ulcerans_Agy99 PVSLSVQAGGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERG
MSMEG_2378|M.smegmatis_MC2_155 PVSLQVQVRGELASEDVEILKLSALRGLFSAVVDEQVTFVNAPALAADRG
TH_2037|M.thermoresistible__bu TATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQVTYVNAPTLAAERG
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0999|M.abscessus_ATCC_1997 TADGSASPGAGT--------------------------------------
MAV_4930|M.avium_104 AQ------------------------------------------------
Mb3020c|M.bovis_AF2122/97 VTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQING
Rv2996c|M.tuberculosis_H37Rv VTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQING
MLBr_01692|M.leprae_Br4923 VSAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSGPQLVQKIVQVNG
MMAR_1715|M.marinum_M VSVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQING
MUL_1952|M.ulcerans_Agy99 VSVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQING
MSMEG_2378|M.smegmatis_MC2_155 VTAEISTATESPNHRSVVDVRAVHADGSSINVAGTLSGPQLVEKIVQING
TH_2037|M.thermoresistible__bu MQAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLSGPQQVEKIVQING
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0999|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4930|M.avium_104 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 RHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPG
Rv2996c|M.tuberculosis_H37Rv RHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPG
MLBr_01692|M.leprae_Br4923 RNFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQAAQLSEDTEGPG
MMAR_1715|M.marinum_M RHFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPG
MUL_1952|M.ulcerans_Agy99 RHFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPG
MSMEG_2378|M.smegmatis_MC2_155 RNFDLRAEGHNLIVNYSDKPGALGKIGTLLGGANVNILAAQLSQDASGDH
TH_2037|M.thermoresistible__bu RNFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNILAAQLSQDISGDG
Mflv_0334|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0999|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4930|M.avium_104 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 ATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv ATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923 ATILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
MMAR_1715|M.marinum_M ATVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MUL_1952|M.ulcerans_Agy99 ATVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MSMEG_2378|M.smegmatis_MC2_155 ATVMLRVDTDVPDDVRAAIADAVGASTLEVVDLS
TH_2037|M.thermoresistible__bu ATLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
Mflv_0334|M.gilvum_PYR-GCK ----------------------------------
Mvan_0404|M.vanbaalenii_PYR-1 ----------------------------------
MAB_0999|M.abscessus_ATCC_1997 ----------------------------------
MAV_4930|M.avium_104 ----------------------------------