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VMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGELLGCVSGALGLRKFFEDGGHELVVT SDKDGPDSEFERELPDADIVISQPFWPAYITKERFAKARNLKLALTAGIGSDHVDLTEAQARGVTVAEET WSNSISVAEHTVMQILALVRNFVPSHQWIRDGGWNIADCVQRSYDVEGMDVGVIAAGRIGRAVLERMKPF GVNLHYFDVHRLSPEYEKQLGVTYHPDVESLARSVDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTA RAEETDHKAIVAALESGQLAGYAGDVWFPQPPPPHHPWRTMPNHAMTPHISGSSLSAQARYCAGTREILE DWFAGRPIRSEYLIVEGGKFAGTGAKSYAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4930 | - | - | 100% (380) | formate dehydrogenase |
| M. avium 104 | MAV_3847 | serA | 1e-29 | 33.33% (273) | D-3-phosphoglycerate dehydrogenase |
| M. avium 104 | MAV_4438 | - | 2e-24 | 30.68% (251) | 2-hydroxyacid dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 5e-27 | 31.87% (273) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4234 | - | 2e-28 | 32.60% (273) | D-3-phosphoglycerate dehydrogenase |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 5e-27 | 31.87% (273) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 3e-27 | 31.87% (273) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0999 | - | 1e-172 | 76.33% (376) | formate dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 1e-30 | 33.33% (273) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. smegmatis MC2 155 | MSMEG_2378 | serA | 1e-30 | 32.60% (273) | D-3-phosphoglycerate dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 4e-30 | 32.60% (273) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 9e-31 | 33.33% (273) | D-3-phosphoglycerate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 4e-29 | 32.97% (273) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4234|M.gilvum_PYR-GCK ----------------------------------MSLPVVLIADKLAQST
Mvan_2128|M.vanbaalenii_PYR-1 ----------------------------------MSLPVVLIADKLAQST
MSMEG_2378|M.smegmatis_MC2_155 ----------------------------------MSLPVVLIADKLAEST
TH_2037|M.thermoresistible__bu ----------------------------------VSLPVVLIADKLAEST
Mb3020c|M.bovis_AF2122/97 ----------------------------------MSLPVVLIADKLAPST
Rv2996c|M.tuberculosis_H37Rv ----------------------------------MSLPVVLIADKLAPST
MLBr_01692|M.leprae_Br4923 ----------------------------------MDLPVVLIADKLAQST
MMAR_1715|M.marinum_M ----------------------------------MNLPVVLIADKLAQST
MUL_1952|M.ulcerans_Agy99 ----------------------------------MNLPVVLIADKLAQST
MAV_4930|M.avium_104 ----MMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGEL
MAB_0999|M.abscessus_ATCC_1997 MAKILCVLYPDPVTGYPPVYARDSLPVIDSYPDGQSLPTPSAIDFTPGEL
.**. * . .
Mflv_4234|M.gilvum_PYR-GCK VEALGDQVEVR--------------WVDGPDREKLLAAVADADALLVR--
Mvan_2128|M.vanbaalenii_PYR-1 VEALGDQVEVR--------------WVDGPDREKLLAAVADADALLVR--
MSMEG_2378|M.smegmatis_MC2_155 VAALGDEVEVR--------------WVDGPDRAKLLAAVPEADALLVR--
TH_2037|M.thermoresistible__bu VAALGDQVEVR--------------WVDGPDREKLLAAVADADALLVR--
Mb3020c|M.bovis_AF2122/97 VAALGDQVEVR--------------WVDGPDRDKLLAAVPEADALLVR--
Rv2996c|M.tuberculosis_H37Rv VAALGDQVEVR--------------WVDGPDRDKLLAAVPEADALLVR--
MLBr_01692|M.leprae_Br4923 VAALGDQVEVR--------------WVDGPDRTKLLAAVPEADALLVR--
MMAR_1715|M.marinum_M VAALGDQVEVR--------------WVDGPDREKLLAAVPEADALLVR--
MUL_1952|M.ulcerans_Agy99 VAALGDQVEVR--------------WVDGPDREKLLAAVPEADALLVR--
MAV_4930|M.avium_104 LGCVSGALGLRKFFEDGGHELVVTSDKDGPDSE-FERELPDADIVISQPF
MAB_0999|M.abscessus_ATCC_1997 LGCVSGELGLRRYLEAHGHELVVTSDKDGPDSV-FEKELPDADVVISQPF
: .:.. : :* **** : :.:** :: :
Mflv_4234|M.gilvum_PYR-GCK SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
Mvan_2128|M.vanbaalenii_PYR-1 SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
MSMEG_2378|M.smegmatis_MC2_155 SATTVDAEVIAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
TH_2037|M.thermoresistible__bu SATTVDAEVLAAAPKLKIVARAGVGLDNVDVEAATARGVLVVNAPTSNIH
Mb3020c|M.bovis_AF2122/97 SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
Rv2996c|M.tuberculosis_H37Rv SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
MLBr_01692|M.leprae_Br4923 SATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIH
MMAR_1715|M.marinum_M SATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNIH
MUL_1952|M.ulcerans_Agy99 SATTVDAEVLAAATKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNIH
MAV_4930|M.avium_104 WPAYITKERFAKARNLKLALTAGIGSDHVDLTEAQARGVTVAEETWSNSI
MAB_0999|M.abscessus_ATCC_1997 WPAYLSAERIAKAPKLKLALTAGIGSDHVDLDAAIKAGITVAEVTYCNSI
.: : * :* * :**:. **:* *:**: * *: *.: . .*
Mflv_4234|M.gilvum_PYR-GCK SAAEHALALLLSTARQIPAADATLREHTWKRSAFSG--TEIFGKTVGVVG
Mvan_2128|M.vanbaalenii_PYR-1 SAAEHALALLLAAARQIPAADATLREHSWKRSSFSG--TEIFGKTVGVVG
MSMEG_2378|M.smegmatis_MC2_155 SAAEHAIALLLATARQIPAADATLRERSWKRSSFSG--TEIFGKTVGVVG
TH_2037|M.thermoresistible__bu SAAEHAIALLLAAARQIPAADATLRQRTWKRSEFSG--VEIYDKTVGVVG
Mb3020c|M.bovis_AF2122/97 SAAEHALALLLAASRQIPAADASLREHTWKRSSFSG--TEIFGKTVGVVG
Rv2996c|M.tuberculosis_H37Rv SAAEHALALLLAASRQIPAADASLREHTWKRSSFSG--TEIFGKTVGVVG
MLBr_01692|M.leprae_Br4923 SAAEHALALLLAASRQIAEADASLRAHIWKRSSFSG--TEIFGKTVGVVG
MMAR_1715|M.marinum_M SAAEHAMALLLAAARQIPAADASLREHTWKRSSFSG--AEIFGKTVGVVG
MUL_1952|M.ulcerans_Agy99 SAAEHAMALLLAAARQIPAADASLREHTWKRSSFSG--AEIFGKTVGVVG
MAV_4930|M.avium_104 SVAEHTVMQILALVRNFVPSHQWIRDGGWNIADCVQRSYDVEGMDVGVIA
MAB_0999|M.abscessus_ATCC_1997 SVAEHAVMQILALVRNYLPAHQWVVDGGWNIADSVERAYDLEGFDVGVIA
*.***:: :*: *: :. : *: : :: . ***:.
Mflv_4234|M.gilvum_PYR-GCK LGRIGQLVAQRLAAFGAHITAYDPY-VSHARAAQLGIELLT-LDELLSRA
Mvan_2128|M.vanbaalenii_PYR-1 LGRIGQLVAQRLAAFGAHITAYDPY-VSHARAAQLGIELLT-LDELLGRA
MSMEG_2378|M.smegmatis_MC2_155 LGRIGQLVAQRLAAFGAHIVAYDPY-VSQARAAQLGIELLP-LDDLLARA
TH_2037|M.thermoresistible__bu LGRIGQLVAQRLAAFGTHLIAYDPY-VSPARAAQLGIELVD-LDELLGRA
Mb3020c|M.bovis_AF2122/97 LGRIGQLVAQRIAAFGAYVVAYDPY-VSPARAAQLGIELLS-LDDLLARA
Rv2996c|M.tuberculosis_H37Rv LGRIGQLVAQRIAAFGAYVVAYDPY-VSPARAAQLGIELLS-LDDLLARA
MLBr_01692|M.leprae_Br4923 LGRIGQLVAARIAAFGAHVIAYDPY-VAPARAAQLGIELMS-FDDLLARA
MMAR_1715|M.marinum_M LGRIGQLVAQRVEAFGAHVVAYDPY-VSPARAAQLGIELLP-LDDLLARA
MUL_1952|M.ulcerans_Agy99 LGRIGQLVAQRVEAFGAHVVAYDPY-VSPARAAQLGIELLP-LDDLLARA
MAV_4930|M.avium_104 AGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLGVTYHPDVESLARSV
MAB_0999|M.abscessus_ATCC_1997 AGRIGQAVLRRLKPFDVRLHYFDTRRLPAEVEHELGLTYHPDVQSLVRSV
****: * *: .*.. : :* :. :**: .:.* .
Mflv_4234|M.gilvum_PYR-GCK DFISVHLPKTKETAGLIGTEALAKTKPGVIIVNAARGGLIDEQALADAIT
Mvan_2128|M.vanbaalenii_PYR-1 DFISVHLPKTKETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAIN
MSMEG_2378|M.smegmatis_MC2_155 DFISVHLPKTKETAGLLGKEALAKTKKGVIIVNAARGGLIDEQALADAIT
TH_2037|M.thermoresistible__bu DIISVHLPKTPETAGLIGADALAKVKPGVIIVNAARGGLIDEQALADAII
Mb3020c|M.bovis_AF2122/97 DFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAIT
Rv2996c|M.tuberculosis_H37Rv DFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAIT
MLBr_01692|M.leprae_Br4923 DFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAVR
MMAR_1715|M.marinum_M DFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAIT
MUL_1952|M.ulcerans_Agy99 DFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAIT
MAV_4930|M.avium_104 DVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIVAALE
MAB_0999|M.abscessus_ATCC_1997 DIVDIHAPLHPQTYHLFDANLINSMRRGSYIVNTARAEITVQEDIVKALE
*.:.:* * :* ::. . : . : * ***:**. . :. *:
Mflv_4234|M.gilvum_PYR-GCK SGHVRGAGLDVFSTEP-CTDSPLFELPQVVVTPHLGASTVEAQDRAGTDV
Mvan_2128|M.vanbaalenii_PYR-1 SGHVRGAGLDVFSTEP-CTDSPLFELPQVVVTPHLGASTVEAQDRAGTDV
MSMEG_2378|M.smegmatis_MC2_155 SGHVRGAGLDVYATEP-CTDSPLFDLPQVVVTPHLGASTAEAQDRAGTDV
TH_2037|M.thermoresistible__bu SGRVRAAGIDVFAKEP-CTDSPLFDLPQVVVTPHLGASTVEAQDRAGTDV
Mb3020c|M.bovis_AF2122/97 GGHVRAAGLDVFATEP-CTDSPLFELAQVVVTPHLGASTAEAQDRAGTDV
Rv2996c|M.tuberculosis_H37Rv GGHVRAAGLDVFATEP-CTDSPLFELAQVVVTPHLGASTAEAQDRAGTDV
MLBr_01692|M.leprae_Br4923 SGHVRAAGLDVFATEP-CTDSPLFELSQVVVTPHLGASTAEAQDRAGTDV
MMAR_1715|M.marinum_M SGHVRGAGLDVFATEP-CTDSPLFELPQVVVTPHLGASTAEAQDRAGTDV
MUL_1952|M.ulcerans_Agy99 SGYVRGAGLDVFATEP-CTDSPLFELPQVVVTPHLGASTAEAQDRAGTDV
MAV_4930|M.avium_104 SGQLAGYAGDVWFPQPPPPHHPWRTMPNHAMTPHISGSSLSAQARYCAGT
MAB_0999|M.abscessus_ATCC_1997 SGQLAGYAGDVWYPQPPAPDHPWRTMPHEAMTPHVSGTTLSAQARYAAGT
.* : . . **: :* .. * :.: .:***:..:: .** * :..
Mflv_4234|M.gilvum_PYR-GCK AASVKLALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGALSAELP
Mvan_2128|M.vanbaalenii_PYR-1 AASVKLALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGVLSSEPP
MSMEG_2378|M.smegmatis_MC2_155 AASVKLALAGEFVPDAVNVGGGVVGEEVAPWLELVRKLGLLVGALADAPP
TH_2037|M.thermoresistible__bu AASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLARKLGLLVGTLSGEPT
Mb3020c|M.bovis_AF2122/97 AESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELP
Rv2996c|M.tuberculosis_H37Rv AESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELP
MLBr_01692|M.leprae_Br4923 AESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCKLGVLVAALSDELP
MMAR_1715|M.marinum_M AASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEPP
MUL_1952|M.ulcerans_Agy99 AASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEPP
MAV_4930|M.avium_104 REILEDWFAGRPIRSEY----------------LIVEGGKFAGTGAKSYA
MAB_0999|M.abscessus_ATCC_1997 REILEDFFGGRSIRDEY----------------LIVEGGQLAGTGAKSYT
:. :.*. : . * : * :... : .
Mflv_4234|M.gilvum_PYR-GCK TNLCVQVRGELASEEVEVLRLSALRGLFSAVIEDQVTFVNAPALATERGV
Mvan_2128|M.vanbaalenii_PYR-1 VSLQVQVQGELASEEVEVLKLSALRGLFSAVIEHPVTFVNAPALASERGV
MSMEG_2378|M.smegmatis_MC2_155 VSLQVQVRGELASEDVEILKLSALRGLFSAVVDEQVTFVNAPALAADRGV
TH_2037|M.thermoresistible__bu ATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQVTYVNAPTLAAERGM
Mb3020c|M.bovis_AF2122/97 VSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGV
Rv2996c|M.tuberculosis_H37Rv VSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGV
MLBr_01692|M.leprae_Br4923 ASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVTFVNAPALAAERGV
MMAR_1715|M.marinum_M VSLSVQARGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERGV
MUL_1952|M.ulcerans_Agy99 VSLSVQAGGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERGV
MAV_4930|M.avium_104 Q-------------------------------------------------
MAB_0999|M.abscessus_ATCC_1997 ADGSASPGAGT---------------------------------------
Mflv_4234|M.gilvum_PYR-GCK EASIDTESESPNHRSVVDVRAVAADGSTVNVSGTLTGPQLVEKIVQINGR
Mvan_2128|M.vanbaalenii_PYR-1 EASITTATESANHRSVVDVRAVAADGSTVNVAGTLTGPQLVEKIVQINGR
MSMEG_2378|M.smegmatis_MC2_155 TAEISTATESPNHRSVVDVRAVHADGSSINVAGTLSGPQLVEKIVQINGR
TH_2037|M.thermoresistible__bu QAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLSGPQQVEKIVQINGR
Mb3020c|M.bovis_AF2122/97 TAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGR
Rv2996c|M.tuberculosis_H37Rv TAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGR
MLBr_01692|M.leprae_Br4923 SAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSGPQLVQKIVQVNGR
MMAR_1715|M.marinum_M SVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQINGR
MUL_1952|M.ulcerans_Agy99 SVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQINGR
MAV_4930|M.avium_104 --------------------------------------------------
MAB_0999|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4234|M.gilvum_PYR-GCK NLDLRAEGVNVIINYHDQPGALGKIGTLLGGANVNILAAQLSQDADGEGA
Mvan_2128|M.vanbaalenii_PYR-1 NLELRAEGVNLIINYDDQPGALGKIGTLLGGAAVNILAAQLSQDADGIGA
MSMEG_2378|M.smegmatis_MC2_155 NFDLRAEGHNLIVNYSDKPGALGKIGTLLGGANVNILAAQLSQDASGDHA
TH_2037|M.thermoresistible__bu NFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNILAAQLSQDISGDGA
Mb3020c|M.bovis_AF2122/97 HFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGA
Rv2996c|M.tuberculosis_H37Rv HFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGA
MLBr_01692|M.leprae_Br4923 NFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQAAQLSEDTEGPGA
MMAR_1715|M.marinum_M HFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPGA
MUL_1952|M.ulcerans_Agy99 HFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPGA
MAV_4930|M.avium_104 --------------------------------------------------
MAB_0999|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4234|M.gilvum_PYR-GCK TIMLRVDREVPADVLAGIGRDVNALTLEVVDLT
Mvan_2128|M.vanbaalenii_PYR-1 TVMLRLDREVPGEVLAAIGRDVNAVTLEVVDLT
MSMEG_2378|M.smegmatis_MC2_155 TVMLRVDTDVPDDVRAAIADAVGASTLEVVDLS
TH_2037|M.thermoresistible__bu TLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
Mb3020c|M.bovis_AF2122/97 TILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv TILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923 TILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
MMAR_1715|M.marinum_M TVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MUL_1952|M.ulcerans_Agy99 TVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MAV_4930|M.avium_104 ---------------------------------
MAB_0999|M.abscessus_ATCC_1997 ---------------------------------