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MKLFSQLRGKTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLPVEYLQVPSAAMNTSIKVQFQNGG AKSVYLLDGLRARDDFSGWDIETTAFEDYYQSGISVVMPVGGQSSWYTDWYQPAKGKDGVFTYKWETFLT QELPAFLANQGLSKTGNAVVGLSMGAASALNLANYHPQQFIYAGALSGFLHPADMKGQIGMAMGDAGGFN PQDMWGPDSDPAWVRNDPFLNIDRTVANGTRLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQY VDAYTAAGGKNAHVEFPPGGLHNWTYWGNQLKAMKSDMVGYLQSH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0177 | - | - | 100% (325) | antigen 85-A/B/C precursor |
| M. abscessus ATCC 19977 | MAB_0176 | - | e-159 | 79.28% (333) | antigen 85-A precursor |
| M. abscessus ATCC 19977 | MAB_1579 | - | e-139 | 71.83% (323) | antigen 85-B precursor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3834c | fbpA | 1e-110 | 60.43% (326) | secreted antigen 85-A FBPA (Mycolyl transferase 85A) |
| M. gilvum PYR-GCK | Mflv_3335 | - | 1e-111 | 60.51% (314) | putative esterase |
| M. tuberculosis H37Rv | Rv3804c | fbpA | 1e-110 | 60.43% (326) | secreted antigen 85-A FBPA (Mycolyl transferase 85A) |
| M. leprae Br4923 | MLBr_00097 | fbpA | 1e-107 | 59.39% (330) | antigen 85A, mycolytransferase |
| M. marinum M | MMAR_0328 | fbpC | 1e-111 | 58.84% (328) | secreted antigen 85-C FbpC |
| M. avium 104 | MAV_0214 | - | 1e-107 | 60.00% (330) | antigen 85-A |
| M. smegmatis MC2 155 | MSMEG_3580 | - | 1e-111 | 61.54% (312) | antigen 85-C |
| M. thermoresistible (build 8) | TH_2078 | fbpA | 1e-109 | 59.76% (328) | SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) |
| M. ulcerans Agy99 | MUL_4793 | fbpC | 1e-111 | 58.84% (328) | secreted antigen 85-C FbpC |
| M. vanbaalenii PYR-1 | Mvan_3061 | - | 1e-110 | 59.88% (324) | putative esterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3335|M.gilvum_PYR-GCK MKWKEKARGTRKSLVRRVAAAALAAAALPGLIGVAGGSATAGAFSRPGLP
Mvan_3061|M.vanbaalenii_PYR-1 MKLKEKWRGTARAAMRRVAAAALAAVALPGLIGFAGGSATAGAFSRPGLP
MSMEG_3580|M.smegmatis_MC2_155 MRGIAAWK-----ALRRFVIGALAALMLPGLIGFAGGSASAGAFSRPGLP
MMAR_0328|M.marinum_M MKFVEKLRGAAAGAPRRLTIAAIGAALLSGLVGAVGGAATAGAFSRPGLP
MUL_4793|M.ulcerans_Agy99 MKFVEKLRGAAAGAPRRLTIAAIGAALLSGLVGAVGGAATAGAFSRPGLP
TH_2078|M.thermoresistible__bu MKLVAKLRGAARALPRRLTVAALAAALLPGLVGAFGGSATAGAFSRPGLP
Mb3834c|M.bovis_AF2122/97 MQLVDRVRGAVTGMSRRLVVGAVGAALVSGLVGAVGGTATAGAFSRPGLP
Rv3804c|M.tuberculosis_H37Rv MQLVDRVRGAVTGMSRRLVVGAVGAALVSGLVGAVGGTATAGAFSRPGLP
MLBr_00097|M.leprae_Br4923 MKFVDRFRGAVAGMLRRLVVEAMGVALLSALIGVVG-SAPAEAFSRPGLP
MAV_0214|M.avium_104 MTLVDRLRGAVAGMPRRLVVGAAGAALLSGLIGAVGGSATAGAFSRPGLP
MAB_0177|M.abscessus_ATCC_1997 MKLFSQLRG---KTARRLATVAAAAAVLPGFIGVAGGSAVANAFSRPGLP
* : **.. * .. :..::* * :* * ********
Mflv_3335|M.gilvum_PYR-GCK VEYLDVFSPSMNRDIRIQFQGGG--PHAVYLLDGLRAQEDYNGWDINTPA
Mvan_3061|M.vanbaalenii_PYR-1 VEYLDVFSPSMGRDIRVQFQGGG--PRAVYLLDGLRAQEDYNGWDINTPA
MSMEG_3580|M.smegmatis_MC2_155 VEYLDVFSPSMNRDIRVQFQGGG--PHAVYLLDGLRAQDDYNGWDINTPA
MMAR_0328|M.marinum_M VEYLQIPSAAMGRDIKVQFQGGG--AHSVYLLDGLRAQDDYNGWDINTPA
MUL_4793|M.ulcerans_Agy99 VEYLQIPSAAMGRDIKVQFQGGG--AHSVYLLDGLRAQDDYNGWDINTPA
TH_2078|M.thermoresistible__bu VEYLMVPSAAMGRDIKVQFQSGGEGSPGVYLLDGLRARDDFNGWDIETAA
Mb3834c|M.bovis_AF2122/97 VEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDINTPA
Rv3804c|M.tuberculosis_H37Rv VEYLQVPSPSMGRDIKVQFQSGGANSPALYLLDGLRAQDDFSGWDINTPA
MLBr_00097|M.leprae_Br4923 VEYLQVPSPSMGRDIKVQFQNGGANSPALYLLDGLRAQDDFSGWDINTTA
MAV_0214|M.avium_104 VEYLQVPSAAMGRDIKVQFQSGGANSPALYLLDGMRAQDDFNGWDINTPA
MAB_0177|M.abscessus_ATCC_1997 VEYLQVPSAAMNTSIKVQFQNGG--AKSVYLLDGLRARDDFSGWDIETTA
**** : *.:*. .*::***.** . .:*****:**::*:.****:*.*
Mflv_3335|M.gilvum_PYR-GCK FEWFYQSGLSTIMPVGGQSSFYSDWYQPSRGNGQNYTYKWETFLTQELPA
Mvan_3061|M.vanbaalenii_PYR-1 FEWFYQSGLSTIMPVGGQSSFYTDWYQPSRGNGQNYTYKWETFLSQELPA
MSMEG_3580|M.smegmatis_MC2_155 FEWFYQSGLSTIMPVGGQSSFYTDWYQPSKGNGQDYTYKWETFLTQELPA
MMAR_0328|M.marinum_M FEEYYNSGLSVVMPVGGQSSFYSDWYQPSQGNGQGYTYKWETFLTREMPA
MUL_4793|M.ulcerans_Agy99 FEEYYNSGLSVVMPVGGQSSFYSDWYQPSQGNGQGYTYKWETFLTREMPA
TH_2078|M.thermoresistible__bu FEWYYESGLSVIMPVGGQSSFYSDWYSPACGNNGCQTYKWETFLTQELPA
Mb3834c|M.bovis_AF2122/97 FEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWETFLTSELPG
Rv3804c|M.tuberculosis_H37Rv FEWYDQSGLSVVMPVGGQSSFYSDWYQPACGKAGCQTYKWETFLTSELPG
MLBr_00097|M.leprae_Br4923 FEWYYQSGISVVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQ
MAV_0214|M.avium_104 FEWYNQSGISVAMPVGGQSSFYSDWYKPACGKAGCTTYKWETFLTSELPQ
MAB_0177|M.abscessus_ATCC_1997 FEDYYQSGISVVMPVGGQSSWYTDWYQPAKGKDGVFTYKWETFLTQELPA
** : :**:*. ********:*:***.*: *: ********: *:*
Mflv_3335|M.gilvum_PYR-GCK WLEANRGVSRTGNAVVGLSMAGSASLTYAIHHPQQFIYAASLSGFLNPSE
Mvan_3061|M.vanbaalenii_PYR-1 WLEANRGVSRTGNAVVGLSMAGSAALTYAIYHPQQFIYAASLSGFLNPSE
MSMEG_3580|M.smegmatis_MC2_155 WLEANRGVSRTGNAVVGLSMAGSAALTYAIYHPEQFIYASTLSGFLNPSE
MMAR_0328|M.marinum_M WLQANKGVSPTGNAAVGLSMSGGSALVLAAYYPQQFPYAASLSGFLNPSE
MUL_4793|M.ulcerans_Agy99 WLQANKGVSPTGNAAVGLSMSGGSALVLAAYYPQQFPYAASLSGFLNPSE
TH_2078|M.thermoresistible__bu YLASNYGVDRNRNAAVGLSMAGSAALVLAIYYPQQFQYAASLSGFLNLSE
Mb3834c|M.bovis_AF2122/97 WLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLLDPSQ
Rv3804c|M.tuberculosis_H37Rv WLQANRHVKPTGSAVVGLSMAASSALTLAIYHPQQFVYAGAMSGLLDPSQ
MLBr_00097|M.leprae_Br4923 YLQSNKQIKPTGSAAVGLSMAGLSALTLAIYHPDQFIYVGSMSGLLDPSN
MAV_0214|M.avium_104 YLSAQKQVKPTGSGVVGLSMAGSSALILAAYHPDQFVYAGSLSALLDPSQ
MAB_0177|M.abscessus_ATCC_1997 FL-ANQGLSKTGNAVVGLSMGAASALNLANYHPQQFIYAGALSGFLHPAD
:* :: :. . ...*****.. ::* * ::*:** *..::*.:*. ::
Mflv_3335|M.gilvum_PYR-GCK GWWPMLIGLAMNDAGGFNAESMWGPSSDP--AWKRNDPMVNINQLVANNT
Mvan_3061|M.vanbaalenii_PYR-1 GWWPMLIGLAMNDAGGFNAESMWGPSSDP--AWKRNDPMVNINQLVANNT
MSMEG_3580|M.smegmatis_MC2_155 GWWPMLIGLAMNDAGGYNAESMWGPSTDP--AWKRNDPMVNINQLVANNT
MMAR_0328|M.marinum_M GWWPTLIGLAMNDSGGYNANSMWGPSTDP--AWKRNDPMVQIPRLVANNT
MUL_4793|M.ulcerans_Agy99 GWWPTLIGLAMNDSGGYNANSMWGPSTDP--AWKRNDPMVQIPRLVANNT
TH_2078|M.thermoresistible__bu GWWPMLVGLAMGDAGGYDPNDMWGRTEDPNSAWKRNDPMVNIDKLVANNT
Mb3834c|M.bovis_AF2122/97 AMGPTLIGLAMGDAGGYKASDMWGPKEDP--AWQRNDPLLNVGKLIANNT
Rv3804c|M.tuberculosis_H37Rv AMGPTLIGLAMGDAGGYKASDMWGPKEDP--AWQRNDPLLNVGKLIANNT
MLBr_00097|M.leprae_Br4923 AMGPSLIGLAMGDAGGYKAADMWGPSTDP--AWKRNDPTVNVGTLIANNT
MAV_0214|M.avium_104 GMGPSLIGLAMGDAGGYKAADMWGPKEDP--AWARNDPSLQVGKLVANNT
MAB_0177|M.abscessus_ATCC_1997 MKG--QIGMAMGDAGGFNPQDMWGPDSDP--AWVRNDPFLNIDRTVANGT
:*:**.*:**:.. .*** ** ** **** ::: :**.*
Mflv_3335|M.gilvum_PYR-GCK RIWIYCGTGTPSDLDSGTPGQNLMAAQFLEGFTLRTNVAFRDNYIAAGGN
Mvan_3061|M.vanbaalenii_PYR-1 RIWIYCGTGTPSDLDNGTPGNNLMAAQFLEGFTLRTNIAFRDNYIAAGGT
MSMEG_3580|M.smegmatis_MC2_155 RLWVYCGTGTPSELDAGVSGGNLLAAQFLEGLTLRTNLTFRDQYIAAGGT
MMAR_0328|M.marinum_M RIWVYCGNGTPSDL-----GGDNMPAKFLEGLTLRTNQTFRDTYLASGGR
MUL_4793|M.ulcerans_Agy99 RIWVYCGNGTPSDL-----GGDNMPAKFLEGLTLRTNQTFRDTYLASGGR
TH_2078|M.thermoresistible__bu RIWVFCGDGTPADIGAGVPEGDNFNAKFLESFTLRTNKTFQQEYIAAGGK
Mb3834c|M.bovis_AF2122/97 RVWVYCGNGKPSDL-----GGNNLPAKFLEGFVRTSNIKFQDAYNAGGGH
Rv3804c|M.tuberculosis_H37Rv RVWVYCGNGKPSDL-----GGNNLPAKFLEGFVRTSNIKFQDAYNAGGGH
MLBr_00097|M.leprae_Br4923 RIWMYCGNGKPTEL-----GGNNLPAKLLEGLVRTSNIKFQDGYNAGGGH
MAV_0214|M.avium_104 RIWVYCGNGKPSDL-----GGDNLPAKFLEGFVRTSNLKFQDAYNGAGGH
MAB_0177|M.abscessus_ATCC_1997 RLWIYCGSGDATDLDATRNGFENFTGGFLEGMAIGSNKQYVDAYTAAGGK
*:*::** * .::: : : . :**.:. :* : : * ..**
Mflv_3335|M.gilvum_PYR-GCK NGVFNFPTSGTHSWGYWGQQLQQMKPDIQRVLGAQATA------------
Mvan_3061|M.vanbaalenii_PYR-1 NGVFNFPTSGTHSWGYWGQQLQQMKPDIQRVLGAQATV------------
MSMEG_3580|M.smegmatis_MC2_155 NAVFNFPPNGTHTWNYWGQQLLEMKPDIQRVLGAQSAT------------
MMAR_0328|M.marinum_M NGVFNFPTNGTHSWPYWNQQLVAMKGDILKVLNGPAVPAAPAAPEAPAAP
MUL_4793|M.ulcerans_Agy99 NGVFNFPTNGTHSWPYWNQQLVAMKGDILKVLNGPAVPAAPAAPEAPAAP
TH_2078|M.thermoresistible__bu NGVFNFPDAGTHSWGYWGQQLQQMKPDIQRVLGVSAA-------------
Mb3834c|M.bovis_AF2122/97 NGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPNTGPAPQGA-----
Rv3804c|M.tuberculosis_H37Rv NGVFDFPDSGTHSWEYWGAQLNAMKPDLQRALGATPNTGPAPQGA-----
MLBr_00097|M.leprae_Br4923 NAVFNFPDSGTHSWEYWGEQLNDMKPDLQQYLGATP-------GA-----
MAV_0214|M.avium_104 NAVWNFDANGTHDWPYWGAQLQAMKPDLQSVLGATPGAGPATAAATNAGN
MAB_0177|M.abscessus_ATCC_1997 NAHVEFPPGGLHNWTYWGNQLKAMKSDMVGYLQSH---------------
*. :* * * * **. ** ** *: *
Mflv_3335|M.gilvum_PYR-GCK -----
Mvan_3061|M.vanbaalenii_PYR-1 -----
MSMEG_3580|M.smegmatis_MC2_155 -----
MMAR_0328|M.marinum_M VAPAA
MUL_4793|M.ulcerans_Agy99 VAPAA
TH_2078|M.thermoresistible__bu -----
Mb3834c|M.bovis_AF2122/97 -----
Rv3804c|M.tuberculosis_H37Rv -----
MLBr_00097|M.leprae_Br4923 -----
MAV_0214|M.avium_104 GQGT-
MAB_0177|M.abscessus_ATCC_1997 -----