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M. thermoresistible (build 8) TH_4039 (-)

annotation: conserved hypothetical membrane protein
coordinates: 2658267 - 2660048
length: 594

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4039--100% (594)conserved hypothetical membrane protein
M. thermoresistible (build 8)TH_0493-e-11540.65% (583) conserved membrane protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1466-1e-12041.92% (594) hypothetical protein Mb1466
M. gilvum PYR-GCKMflv_2113-1e-11440.57% (594) hypothetical protein Mflv_2113
M. tuberculosis H37RvRv1431-1e-11941.75% (594) hypothetical protein Rv1431
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4552-1e-10940.48% (583) hypothetical protein MAB_4552
M. marinum MMMAR_1581-0.069.23% (598) hypothetical protein MMAR_1581
M. avium 104MAV_3343-1e-12543.30% (582) hypothetical protein MAV_3343
M. smegmatis MC2 155MSMEG_5202-1e-10838.49% (582) hypothetical protein MSMEG_5202
M. ulcerans Agy99MUL_3453-0.069.23% (598) hypothetical protein MUL_3453
M. vanbaalenii PYR-1Mvan_4591-1e-11541.58% (594) hypothetical protein Mvan_4591

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2113|M.gilvum_PYR-GCK          MGFLKQDAPVVDYAEWSKGTRAERIVPMARHWAEVGFGTPVVIHLFYVVK
Mvan_4591|M.vanbaalenii_PYR-1       MGFLKQDAPVVDYAEWSKGTRAERIVPMARHWAEVGFGTPVVLHLFYVVK
MSMEG_5202|M.smegmatis_MC2_155      MGFLKQTAPQVDFEEWSKGTRAEKIRPMARHWAEVGFGTPVALHLFYVVK
MAB_4552|M.abscessus_ATCC_1997      MGFLKPTLPVVDVADWGKGTRAEKIRPMARHWAEVGFGTPVALHLFYVLK
Mb1466|M.bovis_AF2122/97            MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVYLLYLTK
Rv1431|M.tuberculosis_H37Rv         MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVYLLYLTK
MAV_3343|M.avium_104                MGFMTPEFPDVDPQTWTGLPRSTRRQIMTRHWVEHGFGSPYAVYLFYVFK
MMAR_1581|M.marinum_M               MGFFKPRFPDVDPDTFLRKPLMERGRILAQSWVEYGFPSPRMVHAIYILK
MUL_3453|M.ulcerans_Agy99           MGFFKPRFPDVDPDTFLRKPLMERGRILAQSWVEYGFPSPRMVHAIYILK
TH_4039|M.thermoresistible__bu      MSFTQHDYPDVEPKEFLRRPLLERIRILSTHWVEHGFGTPFMVPLVYVAK
                                    *.*     * *:   :   .   :   ::  *.* ** :*  :  .*: *

Mflv_2113|M.gilvum_PYR-GCK          ILLYVLVAWLIVLS-TSGIDGFTDVAAWYHEPIVYQKVVFYTMLFEVVGL
Mvan_4591|M.vanbaalenii_PYR-1       ILLYILVAWLIVLT-TSGIDGFTNVAAWYHEPIVYQKVVFYTMLFEVVGL
MSMEG_5202|M.smegmatis_MC2_155      ICLYVLGAWLVVLS-TRGIDGFTAVADWWTEPIVFEKVVLYTMLYEVVGL
MAB_4552|M.abscessus_ATCC_1997      IALYILGGWLFAMVTTEGIDRWTDFS----LPIVFQKVVLYTMLFEVVGL
Mb1466|M.bovis_AF2122/97            IAVYVAAGAAIISL-TPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGF
Rv1431|M.tuberculosis_H37Rv         IAVYVAAGAAIISL-NPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGF
MAV_3343|M.avium_104                IAGYVAGAAAVISL-TPGLGGLGRIADWWTQPIVYQKLVVFTLLFEILGL
MMAR_1581|M.marinum_M               LIFGYALGGVIVATLTSGLPAFWHVAAWWNQPIVYQKVILWTVLLESIGV
MUL_3453|M.ulcerans_Agy99           LIFGYALGVVIVATLTSGLPAFWHVAAWWNQPIVYQKVILWTVLLESIGV
TH_4039|M.thermoresistible__bu      VTLLYILGGVVIATVTSGLPAFWHVSQWWDQPIVYQKFILWTVLLEAIGL
                                    :      .  .    . *:     ..     ***::*.:.:*:* * :*.

Mflv_2113|M.gilvum_PYR-GCK          GCGFGPLNNRFFPPMGSVLYWLRPRTIRLPPWPNRVPLTAGDTRTPVDVV
Mvan_4591|M.vanbaalenii_PYR-1       GCGFGPLNNRFFPPMGSILYWLRPRTIRLPPWPNRVPLTAGDSRTPFDVL
MSMEG_5202|M.smegmatis_MC2_155      GCGFGPLNNRFFPPMGSILYWLRPKTIRLPPWPDRVPLTKGDTRTVFDAV
MAB_4552|M.abscessus_ATCC_1997      GCGFGPLNNRFFPPLGSILYWLRPNTIRLPPWP-RIPLTKGSARTAVDIA
Mb1466|M.bovis_AF2122/97            GCGSGPLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVA
Rv1431|M.tuberculosis_H37Rv         GCGSGPLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVA
MAV_3343|M.avium_104                GCGSGPLTARFWPPFGGFLYWLRPNTIRLPPWPDKVPFTAGDSRTVVDVA
MMAR_1581|M.marinum_M               AGSWGPLAGKIKPMTGGIRFWARPGTIRLRPWK-WVPFTKGDRRTLLDVA
MUL_3453|M.ulcerans_Agy99           AGSWGPLAGKIKPMTGGIRFWTRPGTIRLRPWK-WVPFTKGDRRTLLDVA
TH_4039|M.thermoresistible__bu      GGSWGPLAGKVKPMTGGIQFWLRRGTIRLRPWA-WVPLTAGNRRGWPDVI
                                    . . ***  :. *  *.. :* *  **** .*   :*:* *. *   *  

Mflv_2113|M.gilvum_PYR-GCK          LYAALLAVLVIALFSDGTG----PIPEIGSEVGVLPVWQTATIIGLLVVA
Mvan_4591|M.vanbaalenii_PYR-1       LYAALLVMLLFALFSDGTG----PIPELGSEVGVLPVWQTATIIGLLVVA
MSMEG_5202|M.smegmatis_MC2_155      LYGALLVVLLIAIFSDGTG----PLPALGTEIGVLPMWQIAAVLVLLAVL
MAB_4552|M.abscessus_ATCC_1997      LYAAFLGMVLVALLSQPT------------AAGLLPTWQTAAILGLLVIT
Mb1466|M.bovis_AF2122/97            LYAIVLIGGVWALLSPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVL
Rv1431|M.tuberculosis_H37Rv         LYAIVLIGGVWALLSPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVL
MAV_3343|M.avium_104                LYLVVLGSGVAALLSPGR----GGPVTAAGDVGLIDPVLVVPAIVALALL
MMAR_1581|M.marinum_M               LYVALLVSVAVALFSPGVPSDSLSAALPGNTSGLVSPALLIAPMVLLVLV
MUL_3453|M.ulcerans_Agy99           LYVALLVSVAVALFSPGVPSDSLSAALPGNTSGLVSPALLIAPMVLLVLV
TH_4039|M.thermoresistible__bu      LYASLLISLVVALLSPGVTTASLLERLPDNTSGLVNPLLMVAPIVLLILV
                                    **  .*     *::*                 *::      . :  * : 

Mflv_2113|M.gilvum_PYR-GCK          GLRDKVIFLAARGEVYG--SLAVCFLFS--GADIIIAAKLVCLTIWIGAA
Mvan_4591|M.vanbaalenii_PYR-1       GLRDKVIFLAARGEVYG--SLAVCFLFS--GADIIIAAKLVCLVIWLGAA
MSMEG_5202|M.smegmatis_MC2_155      GLRDKVIFLAARGEVYA--SFTVAFLFAGHGVDAILAAKLVCMVIWLGAA
MAB_4552|M.abscessus_ATCC_1997      GLRDKVIFLAARGEVYG--ALTVAFLFT--GADMIMAAKLIFMVIWIGAA
Mb1466|M.bovis_AF2122/97            GLRDKTIFLAARGEHYW--LKLFVFFFP--FTDQIAAFKIIMLCLWWGAA
Rv1431|M.tuberculosis_H37Rv         GLRDKTIFLAARGEHYW--LKLFVFFFP--FTDQIAAFKIIMLCLWWGAA
MAV_3343|M.avium_104                GLRDKTIFLAARGEHYG--LTLLVFFFG--FTDQIAAFKIIMLALWWGAA
MMAR_1581|M.marinum_M               GLRDKTIFLGARGEQYLPAMFFFAVLGFANFADMIIALKLLIVVVWVGAG
MUL_3453|M.ulcerans_Agy99           GLRDKTIFLGARGEQYLPAMFFFAVLGFANFADMIIALKLLIVVVWVGAG
TH_4039|M.thermoresistible__bu      GLRDKTIFLAARGEQYLPAMVFFAVLGFT---DMIVALKLLIVVVWVCAG
                                    *****.***.**** *      . .:      * * * *:: : :*  *.

Mflv_2113|M.gilvum_PYR-GCK          TSKLNKHFPFVISTMMSNNPVIRPR---SIKRKFFEHFPDDLRPGRASRV
Mvan_4591|M.vanbaalenii_PYR-1       TSKLNKHFPFVISTMMSNNPVMRPR---WIKRKFFEHFPDDLRPGRASRF
MSMEG_5202|M.smegmatis_MC2_155      TSKLNKHFPFVISTMMSNNPVLRPR---FIKRKFFEHFPDDLRPGRPSRW
MAB_4552|M.abscessus_ATCC_1997      TSKLNRHFPFVISTMMSNNPLIRAR---RLKRAFFEKFPDDLRPGRLSRV
Mb1466|M.bovis_AF2122/97            TSKLNHHFPYVVAVMTSNNALLRSRVFNPIKHLLYRDHANDLRPSWLPKL
Rv1431|M.tuberculosis_H37Rv         TSKLNHHFPYVVAVMTSNNALLRSRVFNPIKHLLYRDHANDLRPSWLPKL
MAV_3343|M.avium_104                TSKLNHHFPYVVAVMMSNSPLLRARAFNWFKRRLYLDPVDDLRPSWIPKV
MMAR_1581|M.marinum_M               ASKFGKHFANVIPPMVSNSPAIAFR---WLKRAHYRNFPRDLRPSRLAEV
MUL_3453|M.ulcerans_Agy99           ASKFGKHFANVIPPMVSNSPAIAFR---WLKRAHYRNFPRDLRPSRLAEV
TH_4039|M.thermoresistible__bu      VSKFGRHFARVIPPMTSNSPTVATLP--AFKRAMYRDPRNDLRPSRLAEF
                                    .**:.:**. *:. * **.. :       :*:  : .   ****.  .. 

Mflv_2113|M.gilvum_PYR-GCK          LAHFS-TAIEMLVPLVLFFSHGG--WPTAIAAFVMLVFHFGILSAIPMGV
Mvan_4591|M.vanbaalenii_PYR-1       LAHFS-TAIEGLVPLVLFFSHGG--WATAIAAFVMLVFHFGILSAIPMGV
MSMEG_5202|M.smegmatis_MC2_155      LAHVS-TAIEMLVPLALFFSHGG--WPTALAATVMICFHFGILSAIPMGV
MAB_4552|M.abscessus_ATCC_1997      VAHVS-TAVEGLVPFALFFSHGG--WVTTVAAGVMVCFHLGILTAIPMGV
Mb1466|M.bovis_AF2122/97            MAHGGGTTAEFLVPGILVLVADGHPWRWFLIG-FMVLFHLNILSNLPMGV
Rv1431|M.tuberculosis_H37Rv         MAHGGGTTAEFLVPGILVLVADGHPWRWFLIG-FMVLFHLNILSNLPMGV
MAV_3343|M.avium_104                MAHVGGTTAEFLVPLVLVFVADGHRWAWFLIA-FMVLFHLNIASTIPMGV
MMAR_1581|M.marinum_M               MAHAAGTTVEILAPLTLLFSTNK--WLTLAAAALMVSFHLFIISTFPLAV
MUL_3453|M.ulcerans_Agy99           MAHAAGTTVEVLAPLTLLFSTNK--WLTLAAAALMVSFHLFIISTFPLAV
TH_4039|M.thermoresistible__bu      MAHVLGTVVEVVAPLVLLFSHNK--TLTVAAVVLMLGLHLYIISAFPLAV
                                    :**   *. * :.*  *.:  .           .*: :*: * : :*:.*

Mflv_2113|M.gilvum_PYR-GCK          PLEWNVFMMFSVLALFVGN---AGIGLGDLQSPWP-IVLFAVVAGTVVIG
Mvan_4591|M.vanbaalenii_PYR-1       PLEWNVFMMFSVLALFVGN---AGIGLADLQSPWP-ILLFAAVAGTVVIG
MSMEG_5202|M.smegmatis_MC2_155      PLEWNVFMIFCVATLFVGH---ADVGITDLSTPLP-LLLLAVLVTTVTLG
MAB_4552|M.abscessus_ATCC_1997      PLEWNVFMIFGVLALFVSH---ANVGLSDMQHPAPVLLLLAVSAGVVATG
Mb1466|M.bovis_AF2122/97            PLEWNVFFIFSLCYLFGHY---GAITATDLRSPLLLAIVIAVVAVV-IMG
Rv1431|M.tuberculosis_H37Rv         PLEWNVFFIFSLCYLFGHY---GAITATDLRSPLLLAIVIAVVAVV-IMG
MAV_3343|M.avium_104                PLEWNVFFIFSLFYLFGHY---AGVTATGLSSPLLLVILIAALAVVPILG
MMAR_1581|M.marinum_M               PLEWNVLFAYATIFLFLGFPAWQGYGVTSMSSPWLLAAIVAALLFFPILG
MUL_3453|M.ulcerans_Agy99           PLEWNVLFAYATIFLFLGFPAWQGYGVTSMSSPWLLAAIVAALLFFPILG
TH_4039|M.thermoresistible__bu      PLEWNVLFSFATVFLFLGFPSWEGYAVGDMSSPWLTVVIVAALLFFPILG
                                    ******:: :    **            .:  *     :.*.       *

Mflv_2113|M.gilvum_PYR-GCK          NLFPRKVSFLPGMRYYAGNWDTTLWCVKPSASEKITSGIVAIASMPAAQM
Mvan_4591|M.vanbaalenii_PYR-1       NLFPRKVSFLPGMRYYAGNWDTTLWCVKPSAAEKIANGIVAIASMPAAQM
MSMEG_5202|M.smegmatis_MC2_155      NLFPRKISFLPGMRYYAGNWDTSLWCVKPSAAEKIEKNIVAIASMPAAQM
MAB_4552|M.abscessus_ATCC_1997      NLLPRKVSFLPGMRYYAGNWDTTLWCIKPSASAKIEKGIVAIASMPQAQM
Mb1466|M.bovis_AF2122/97            NLLPEKISFLPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQL
Rv1431|M.tuberculosis_H37Rv         NLLPEKISFLPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQL
MAV_3343|M.avium_104                NLFPQQISFLPAMRYYAGNWATSTWCFRRGAEDKIEANITKASALVPNQL
MMAR_1581|M.marinum_M               NFRPDKVSFLPSMRQYAGNWASAVWAFAPGTEHKLNK-VTRSSKNQLDQF
MUL_3453|M.ulcerans_Agy99           NFRPDKVSFLPSMRQYAGNWASAVWAFAPGTEHKLNK-VTRSSKNQLDQF
TH_4039|M.thermoresistible__bu      NVRPDKVSFLPSMRQYSGNWACSVWAFAPGAEAKLDR-VKRPAINQIDQF
                                    *. * ::****.** *:***  : *..  .:  .:   :   :     *:

Mflv_2113|M.gilvum_PYR-GCK          EKFYGSKETAEMYQYMGYAFRSFNTHGRAMFTLAHRAMAGQ-DEGEYVLT
Mvan_4591|M.vanbaalenii_PYR-1       EKFYGSKETAEVYQYMGYAFRSFNTHGRAMFTLAHRAMADG-SEDDYVLT
MSMEG_5202|M.smegmatis_MC2_155      ERYYGSPETAQMYLYMGYAFRGFNSHGRALFTLAHRAMAGH-DEGEYVLT
MAB_4552|M.abscessus_ATCC_1997      ERYYGSKDAAQIYMYIGYAFRAMNTHGRAMFTLAHRAMAGQ-DESEYVIT
Mb1466|M.bovis_AF2122/97            AKLYDG-ATAEIMTDQVAAFRAMHTHGRALNGLLPRALD---DEAHYRIR
Rv1431|M.tuberculosis_H37Rv         AKLYDG-ATAEIMTDKVAAFRAMHTHGRALNGLLPRALD---DEAHYRIR
MAV_3343|M.avium_104                ARLYDP-QSAELMIDKLMGWRSMHTHGRALGGLVPRALPGGADEADYLLR
MMAR_1581|M.marinum_M               IDFGYEPQWAEITMQHSIAWRSMHSQGRGLFSVLLKNLP---DIDTRTVR
MUL_3453|M.ulcerans_Agy99           IDFGYEPQWAEITMQRSIAWRSMHSQGRGLFSVLLKNLP---DIDTRTVR
TH_4039|M.thermoresistible__bu      IAYGYEPEWAAVIMNLPATFRAMHTQGRGLLSVLVKNLP---DIDTRTVR
                                             * :       :*.::::**.:  :  : :    .     : 

Mflv_2113|M.gilvum_PYR-GCK          DGERICSTAIGWNFGDGHMHNEQLITALQKRCRFEPGEVRVLILDAQPIH
Mvan_4591|M.vanbaalenii_PYR-1       DGERICSTAIGWNFGDGHMHNEQLIAALQKRCQFEPGEVRVLLLDAQPIH
MSMEG_5202|M.smegmatis_MC2_155      DGERIVSTAIGWNFGDGHMSNEQLVDALQKRCHFEPGEVRIVMLDAQPIQ
MAB_4552|M.abscessus_ATCC_1997      DGERICSTAIGWNFGDGHMHNEQLIAAMQERCHFEPGEVRIVLLDAQPIH
Mb1466|M.bovis_AF2122/97            EGEIVAGPLVGWNFGEGHLHNEQLVAAVQRRCNFADGDLRVIILEGQPIH
Rv1431|M.tuberculosis_H37Rv         EGEIVAGPLVGWNFGEGHLHNEQLVAAVQRRCNFADGDLRVIILEGQPIH
MAV_3343|M.avium_104                DGEIVAGPLIGWNFGEGHLHNEQLLAAVQRRCNFDEGEVRVIILEAQPIQ
MMAR_1581|M.marinum_M               EGEFICNSLIGFNFGDGHLHNEDLIAAMQTQAAFEPGELVVVWVESQAWG
MUL_3453|M.ulcerans_Agy99           EGEFICNSLIGFNFGDGHLHNEDLIAAMQTQAAFEPGELVVVWVESQAWG
TH_4039|M.thermoresistible__bu      EGEWVCNSLIGWNFGDGHLHDERMIAAVQEQVGFEPGDLVVAWAESQAWG
                                    :** : .. :*:***:**: :* :: *:* :  *  *:: :   :.*.  

Mflv_2113|M.gilvum_PYR-GCK          KQRQEYRLVDAATGEFERGYVMVADMVTRQPWD---DTVPVHVTWQKSG-
Mvan_4591|M.vanbaalenii_PYR-1       RQRQEYRLVDAATGEFERGYVMVADMVTRQPWD---DTVPVHVTWRR---
MSMEG_5202|M.smegmatis_MC2_155      RQTQNYRLVDAATGEFERGYVKVADMVTRQPWD---DDVPVHGVHSLSGE
MAB_4552|M.abscessus_ATCC_1997      RQTQRYRLVDAATGEFESGYVRVADMVNRQPWD---DELPVQVNS-----
Mb1466|M.bovis_AF2122/97            VQKQWYRIVDAKTGLFEAGYVTVEDMLSRQPWPEPGDEFPVHVTTQRGTP
Rv1431|M.tuberculosis_H37Rv         VQKQWYRIVDAKTGLFEAGYVTVEDMLSRQPWPEPGDEFPVHVTTQRGTP
MAV_3343|M.avium_104                RQTQAYRIVDAKTGLIEAGHVDVASMLSRQPWPEPGDEYPVHVHG-----
MMAR_1581|M.marinum_M               SKVQHYKVIDAALGVLERGTWKVADAVAEQPWLP-NGPIPTQVTWSLGGR
MUL_3453|M.ulcerans_Agy99           SKVQHYKVIDAALGVLERGTWKVADAVAEQPWLP-NGPIPTQVTWSLRGR
TH_4039|M.thermoresistible__bu      SPVQHYKLIDAALGVIETGTWRVDDVAEAQPWLP-NGPVPTTVTWS----
                                       * *:::**  * :* *   * .    ***    .  *.         

Mflv_2113|M.gilvum_PYR-GCK          ----------------
Mvan_4591|M.vanbaalenii_PYR-1       ----------------
MSMEG_5202|M.smegmatis_MC2_155      RREHA-----------
MAB_4552|M.abscessus_ATCC_1997      ----------------
Mb1466|M.bovis_AF2122/97            SKP-------------
Rv1431|M.tuberculosis_H37Rv         SKP-------------
MAV_3343|M.avium_104                ----------------
MMAR_1581|M.marinum_M               RERIRDGQDREHGALA
MUL_3453|M.ulcerans_Agy99           RERIRDGQEREHGALA
TH_4039|M.thermoresistible__bu      --RFRDGR----GAVV