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M. thermoresistible (build 8) TH_3700 (-)

annotation: MMPL domain protein
coordinates: 286129 - 287550
length: 474

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3700--100% (474)MMPL domain protein
M. thermoresistible (build 8)TH_3087-2e-3828.90% (474) PUTATIVE MmpL11
M. thermoresistible (build 8)TH_2203mmpL87e-3731.78% (343) PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0208cmmpL113e-3929.41% (476) transmembrane transport protein MmpL11
M. gilvum PYR-GCKMflv_0224-0.075.69% (469) MMPL domain-containing protein
M. tuberculosis H37RvRv0202cmmpL113e-3929.41% (476) transmembrane transport protein MmpL11
M. leprae Br4923MLBr_02617-2e-3527.00% (474) hypothetical protein MLBr_02617
M. abscessus ATCC 19977MAB_0937c-1e-3535.32% (269) MmpL family protein
M. marinum MMMAR_1673-1e-17468.94% (470) transmembrane transport protein
M. avium 104MAV_3895-1e-17468.67% (466) MmpL family protein
M. smegmatis MC2 155MSMEG_0763-0.074.89% (470) antibiotic transporter
M. ulcerans Agy99MUL_1909-1e-17268.30% (470) transmembrane transport protein
M. vanbaalenii PYR-1Mvan_0683-0.075.85% (468) MMPL domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0224|M.gilvum_PYR-GCK          ------------MSRRFSWVIALLVVLVSGALMGLLGGGDSSSQSPVAVP
Mvan_0683|M.vanbaalenii_PYR-1       ------------MSRRYSWVVALLVVLLSGALMGLLGGGDSGSQSPLIVP
MSMEG_0763|M.smegmatis_MC2_155      ------------MS-----WLAVLVVIISGGLMGVLSGGDSASQSPVAVP
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               ---MVWDRLAAALAAKRSWLISVGVVALATVFMVLVGGNSAAGQAPQSVP
MUL_1909|M.ulcerans_Agy99           ---MVWDRLAAALAAKRSWLISVGVVALATVFMVLVGGNSAAGQAPQSVP
MAV_3895|M.avium_104                ---MVWERVAAAVTGPRSWLLAAVAVLAGVGVMALVGPNTAAGQAPQSLP
MAB_0937c|M.abscessus_ATCC_199      MRRLADLVVRWPWVVIGAWVALAIALPLTFPSLTEMAEKHPLAILPADAP
Mb0208c|M.bovis_AF2122/97           -----MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVA
Rv0202c|M.tuberculosis_H37Rv        -----MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVA
MLBr_02617|M.leprae_Br4923          ------MRLSSYLRRFRWLVFTGWLLALVPAIYLAMTQSGKLTGGGFEVA
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          ADSESARADAARAALPGGDQVPAILVVTRTDSAPLGPADLAAVDGARDRM
Mvan_0683|M.vanbaalenii_PYR-1       PDAESARADAARAALPDGDQVPAILVVTRADAAPLTPADVAAANSARDRM
MSMEG_0763|M.smegmatis_MC2_155      SDAESARADALRADFPGGDQAPAILVVTRADGAELGPDDIDAAAEARHRM
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               ADAESAKVESELGRFPGGDRAPLILVVTRSDGTTLDAADRRAAQQAAQRM
MUL_1909|M.ulcerans_Agy99           ADVESAKVESELGRFPGGDRAPLILVVTRSDGTTLDAADRRAAQQAAQRM
MAV_3895|M.avium_104                QHSPSARITALAGQFPGGDRTPLIVVVSRADGAVLGPADLGAARAARDRA
MAB_0937c|M.abscessus_ATCC_199      SSVTAKKMTEAFHESSNDDLLLVVFINENGLGKDDADSYRKVVDALRHDL
Mb0208c|M.bovis_AF2122/97           GSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDN-AVALLRQIA
Rv0202c|M.tuberculosis_H37Rv        GSQSLLVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDN-AVALLRQIA
MLBr_02617|M.leprae_Br4923          GSQSLLVHDQLQEQYPDQGAVSLALVAAPRSDASYQDMND-AVALLRRIV
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          L--AAAQS---GPAGPPVQVSDDGQAAVATVPMSSDLSGFDLTDTVTELR
Mvan_0683|M.vanbaalenii_PYR-1       L--TVAGN---AAGGPPTQVSEDGQAAVATVPLSADLSGFALTDKVKEVR
MSMEG_0763|M.smegmatis_MC2_155      S--DAP--------GPPMVVSDDGKAAISTVPLDATLSGFALTDEVKELR
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               Q--AAAHPGANPRPAAPLIS-ADTKAAISVVPISANLSGLALNDAVKALR
MUL_1909|M.ulcerans_Agy99           Q--ASAHPGANPRPAAPLIS-ADTKAAISVVPISANLSGLALNDAVKALR
MAV_3895|M.avium_104                Q--AAAQPGAAP--AQPLTPSQDGKAALGVVPLSTTLSGLALNDAVSALR
MAB_0937c|M.abscessus_ATCC_199      TNVVSVQDFIGTPELRKFLTSQDNKTWVLPVGLAGELGTPKAFESYNRVT
Mb0208c|M.bovis_AF2122/97           SELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVK
Rv0202c|M.tuberculosis_H37Rv        SELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVK
MLBr_02617|M.leprae_Br4923          SEFPGVSEVPNPTQLPPRPDRPYGVSLRLDDRNSVTSDVAKQLRTKVGIK
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          GAATDGLPEG-LQAQVTGGPAFGADIANSFSGANFTLLAVTAAVVALLLI
Mvan_0683|M.vanbaalenii_PYR-1       TAAADGLPGD-LRAQVTGGPAFGADIADSFSGANVTLLAVTAAVVALLLI
MSMEG_0763|M.smegmatis_MC2_155      ANAAEGLPGD-LRAEVTGGPAFGADIANSFAGANVTLLAVTAIVVALLLI
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               EAAHEGLPAD-LDAHVTGGPAFGADIANAFTNANITLLAVTASVVALLLI
MUL_1909|M.ulcerans_Agy99           EAAHEGLPAD-LDAHVTGGPAFGADIANAFTNANITLLAVTASVVALLLI
MAV_3895|M.avium_104                TAAATGLAAD-LQVHVTGGPAFGADIAGAFTHANVTLLAVTASVVALLLI
MAB_0937c|M.abscessus_ATCC_199      SLIQHSIDGSPTTVHITGPAATVADLTVAGQQDRLPIEIAIAVLVLAVLL
Mb0208c|M.bovis_AF2122/97           GDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLV
Rv0202c|M.tuberculosis_H37Rv        GDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLV
MLBr_02617|M.leprae_Br4923          GDQAGRTANGKVRLYVIGQGALSAAVAANSKHDIAEAERWNLPIILIVLL
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          ITYRSPVLWLVPLLVIGFADRVAAVIGSAVAEALGMSPDGSTSGITSVLV
Mvan_0683|M.vanbaalenii_PYR-1       VTYRSPVLWLVPLLVIGFADRVAAVAGAAVAETLGMSPDGSTAGITSVLV
MSMEG_0763|M.smegmatis_MC2_155      VTYRSPILWLVPLLVIAFADRVGSVVGTAVASGLGMNPDGSTGGITSVLV
TH_3700|M.thermoresistible__bu      ------------------------XVGSHIADAFGLMPDGSTSGITSVLV
MMAR_1673|M.marinum_M               LTYRSPVLWLLPLLVIAFADRVATTVGTAVAALTGLNFDGSTSGITSVLV
MUL_1909|M.ulcerans_Agy99           LTYRSSVLWLLPLLVIAFADRVATTVGTAVAALTGLNFDGSTSGITSVLV
MAV_3895|M.avium_104                ATYRSPVLWLVPLLVVAFADRVAAAVGTAVASLTGLSFDGATSGITSVLV
MAB_0937c|M.abscessus_ATCC_199      LVYRSALTMMLPLVTIGSSLVIAQSVVAAYSQLTGAGVSNQSIVFLSAIL
Mb0208c|M.bovis_AF2122/97           AVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTST--VSMFG
Rv0202c|M.tuberculosis_H37Rv        AVFGSLAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTST--VSMFG
MLBr_02617|M.leprae_Br4923          AVFGSLAAAAVPLALGVCTVVVTMGLVDLVSMHTIMSVFVTST--VSMFG
                                                                  :          :    * : 

Mflv_0224|M.gilvum_PYR-GCK          FGAGTNYALLLISRYREELGR-----TDSHNDAIDTAVRRAGPAIIASNA
Mvan_0683|M.vanbaalenii_PYR-1       FGAGTNYALLLISRYREELGR-----SESHRDALGTAVRRAGPAIIASNA
MSMEG_0763|M.smegmatis_MC2_155      FGAGTNYALLLISRYREELGR-----TENHRDALQASVRAAAPAIIASNA
TH_3700|M.thermoresistible__bu      FGAGTNYSLLLISRYREELGRGGEQAHPDHHAALRVAVRNAGPAILASNA
MMAR_1673|M.marinum_M               FGAGTNYALLLISRYRQELPV-----HRDHRDALARAVRMAGPAIAASNA
MUL_1909|M.ulcerans_Agy99           FGAGTNYALLLISRYRQELPV-----HRDHRDALARAVRMAGPPIAASNA
MAV_3895|M.avium_104                FGAGTNYALLLISRYRQELRR-----HAGHRDALRRAVHRAGPAIVASNA
MAB_0937c|M.abscessus_ATCC_199      AGAGTDYAVFLISRYHDYLRS-----GKNYDQAVRAAMMSIGKVITASAT
Mb0208c|M.bovis_AF2122/97           IALAVDYSLFILMRYREELRC-----GRRPPDAVDAAMATSGLAVVLSGM
Rv0202c|M.tuberculosis_H37Rv        IALAVDYSLFILMRYREELRC-----GRRPPDAVDAAMATSGLAVVLSGM
MLBr_02617|M.leprae_Br4923          IALAVDYSLFILMRFREELRS-----GRQPQEAVDAAMATSGLAVVLSGM
                                     . ..:*::::: *::: *             *:  ::   .  :  *  

Mflv_0224|M.gilvum_PYR-GCK          TVVLALLTLLFASSPSTRSLGVQAAAGLVVAAVFVLLVLPPALAVFGRKL
Mvan_0683|M.vanbaalenii_PYR-1       TVVLALLTLLLASSPSTRSLGVQAASGLVIAAVFVLLVLPPALGVFGRKL
MSMEG_0763|M.smegmatis_MC2_155      TVVLALLTLLFATAPSNRSLGVQAASGLVVAAVFVLIVLPPLLALCGKRL
TH_3700|M.thermoresistible__bu      TVVLALLTLLFGVVPSTRSLGLQAASGLVVAAVFVLLVLPPLLALFGRRL
MMAR_1673|M.marinum_M               TVVLALLTLVFAATPSTRSLGALAACGLVVAAVSVLVVLPPLLALCGRRL
MUL_1909|M.ulcerans_Agy99           TVVLALLTLVFAATPSNRSLGALAACGVVVAAVSVLVVLPPLLALCGRRL
MAV_3895|M.avium_104                TVVLALLTLLLAATPSTRSLGALAACGLVIAAVSVLVVLPPLLAVCGRRL
MAB_0937c|M.abscessus_ATCC_199      TVGITFLLLSFAKMGVFQTVGVSSAIGIGVAYLSGMTLLPAILVLAGPR-
Mb0208c|M.bovis_AF2122/97           TVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAA
Rv0202c|M.tuberculosis_H37Rv        TVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAA
MLBr_02617|M.leprae_Br4923          TVIASLTGIYLINTAALKSMATGAILAVAIAMLASITLTPAALATFGRAA
                                    **  ::  : :      :::.  :  .: :* :    : *. *   .   

Mflv_0224|M.gilvum_PYR-GCK          FW--PFIPAVGDQPLTDSGVWHRIAAAVARRPARVAIVSIGGLALLCTGI
Mvan_0683|M.vanbaalenii_PYR-1       FW--PFIPQVGAKPLTDSGVWHRVAAAVARRPARVAIVSIGGLALLCTGL
MSMEG_0763|M.smegmatis_MC2_155      FW--PFIPKVGATALTESGVWHRIADTVARRPARVVVVSVAGLALLCTAL
TH_3700|M.thermoresistible__bu      FW--PFVPQPGAEPLTDSGLWRRIADWVADRPGPVAAATLAVLAVMCTGL
MMAR_1673|M.marinum_M               FW--PFIPRAEDTTALDSGFWHAVAQRVARRPAPVALVTVALLIGLATGL
MUL_1909|M.ulcerans_Agy99           FW--PFIPRAEDTTALDSGFWHAVAQRVARRPAPVALVTVALLIGLATGL
MAV_3895|M.avium_104                FW--PFIP--VDRPATESGAWRRVAEWVAGRPALVAVAAVAVLAALGGGL
MAB_0937c|M.abscessus_ATCC_199      -------GWVKPRRELTAQFWRRSGIRIVRRPIPHLVASVLVLALLGSCA
Mb0208c|M.bovis_AF2122/97           AKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPA
Rv0202c|M.tuberculosis_H37Rv        AKRSALVHWSRRPASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPA
MLBr_02617|M.leprae_Br4923          VKRSVLMHWSQRSECTQSLFWTRWVGWVMHRPWISASAASTILIIMATPV
                                                     :  *      :  **     .:   *  :    

Mflv_0224|M.gilvum_PYR-GCK          LGTPVGLSQTEQFRVEAESVRGFDTLAAHFPSGLTDPTRVIATSDRS---
Mvan_0683|M.vanbaalenii_PYR-1       LGTPVGLSQTEQFRVQAESVSGFETLAAHFPSGLTAPARVIASTDRA---
MSMEG_0763|M.smegmatis_MC2_155      LTTPIGLTQTEQFRVQAESVSGFETVSAHFPSGLTDPTRVIASTDKA---
TH_3700|M.thermoresistible__bu      LGTPIGLSQTEQFRVQAESVTGYETLAAHFPRGITDPTQVLASTERA---
MMAR_1673|M.marinum_M               LGTRIGLSQTEQFRVKADSVSGYDVVAQHFPAGLVNPTLVVAPSAQA---
MUL_1909|M.ulcerans_Agy99           LGTRIGLSQTEQFRVKADSVSGYDVVAQHFPAGLVNPTLVVAPSAQA---
MAV_3895|M.avium_104                WGTRIGLSQTEQFRVRADSVAGYHVLAQHFPAGLANPTLVVADTGHA---
MAB_0937c|M.abscessus_ATCC_199      LLARYNYDDRKAVSPSAPSSVGYAALERHFPLSQSIPEYILIQSPRD---
Mb0208c|M.bovis_AF2122/97           TLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---
Rv0202c|M.tuberculosis_H37Rv        TLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---
MLBr_02617|M.leprae_Br4923          TSMMLGNSLLRQFNSSHEIRAGVAAAAQALGPGALGPVQVLITFPDDPNT
                                         .    . .        *  .    :  .   *  ::         

Mflv_0224|M.gilvum_PYR-GCK          -AEVQRAITATPGVVSAFPAGAE---ADGRS-------------------
Mvan_0683|M.vanbaalenii_PYR-1       -AEVQRAITATPGVVSAIPAGSG---PGGVS-------------------
MSMEG_0763|M.smegmatis_MC2_155      -AAVQRAITDTEGVVSASPAGES---PTGLT-------------------
TH_3700|M.thermoresistible__bu      -NEVELAITETPGVVSAAESGRS---GTGLT-------------------
MMAR_1673|M.marinum_M               -TQVRQAIGATPGVVSVTESGRSGKFGAGLT-------------------
MUL_1909|M.ulcerans_Agy99           -TQVRQAIGATPGVVSVTESGRSGKFGAGLT-------------------
MAV_3895|M.avium_104                -AAVHQAMAATPGVVSATESGRS---ASGLT-------------------
MAB_0937c|M.abscessus_ATCC_199      -LRTPQALADLEQMASRIAQLPDVGLVSGVTRPLGEVPPEFRATYQAGLV
Mb0208c|M.bovis_AF2122/97           GASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFAD----------------
Rv0202c|M.tuberculosis_H37Rv        GASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFAD----------------
MLBr_02617|M.leprae_Br4923          QASSPKHRQTIGAIRNRMLQAKNVMSVAPPQFAD----------------
                                                 :                                    

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      GTRLADGSNQINQRSSDLNRLTSGANTLAGSLTDLRNQLNKITPGLQSLL
Mb0208c|M.bovis_AF2122/97           --------------------------------------------------
Rv0202c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02617|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      EASNSLKTKSGGDELVRNVDNAAKLVDEINALANDMGWNFSAAKDMFGWI
Mb0208c|M.bovis_AF2122/97           --------------------------------------------------
Rv0202c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02617|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      NPVLAALQGNPICDADTSCSNTRGQFERLVGERNSGRLDEIERLAHQLGN
Mb0208c|M.bovis_AF2122/97           --------------------------------------------------
Rv0202c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02617|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      SPGNKATLSTTVTKLNASLLSVVNGLHAMGLDKPGGPQAGLNQLRQGADR
Mb0208c|M.bovis_AF2122/97           --------------------------------------------------
Rv0202c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02617|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      LAGGSQQVAGGVDQLVGQIKVIVNGLNQASNFLLTMKTNAADPSQAGFNI
Mb0208c|M.bovis_AF2122/97           --------------------------------------------------
Rv0202c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_02617|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          -------------------------QWSVVLDAEPASDEAFDTIDALRES
Mvan_0683|M.vanbaalenii_PYR-1       -------------------------QWSVVLEAAPASDAAFEAVDALRDS
MSMEG_0763|M.smegmatis_MC2_155      -------------------------QWSVVLGADPASDEAFETIDALRGS
TH_3700|M.thermoresistible__bu      -------------------------QWSVVLDAEPASAEAFETVDALRDS
MMAR_1673|M.marinum_M               -------------------------KWSVVIDAPPSSERAFTTIAALRHS
MUL_1909|M.ulcerans_Agy99           -------------------------KWSVVIDAPPSSERAFTTIAALRHS
MAV_3895|M.avium_104                -------------------------QWSVVIDAPPSSVRAFDIVAALRDS
MAB_0937c|M.abscessus_ATCC_199      PAEVLNNPDFQRAAKAFISPDGHSVRYLVQTKLNPFSPEAMDQVNQISDV
Mb0208c|M.bovis_AF2122/97           --------------------DNGSALLSAVLSVDPEDLGARDTITWMRTQ
Rv0202c|M.tuberculosis_H37Rv        --------------------DNGSALLSAVLSVDPEDLGARDTITWMRTQ
MLBr_02617|M.leprae_Br4923          --------------------NNCSALLGAVLSVDPEDLGARETVDWMRTE
                                                                .     * .  *   :  :   

Mflv_0224|M.gilvum_PYR-GCK          VH-------RADPDALVGGSDATARDAAAAAGHDRAVVIPAILVVVLIVL
Mvan_0683|M.vanbaalenii_PYR-1       VH-------RVDPDALVGGSDATARDAASAAAHDRAVVIPAILVVVLLVL
MSMEG_0763|M.smegmatis_MC2_155      VQ-------HADADAVVGGSDAQARDAAAAAQRDRAVVIPAILVVVLAVL
TH_3700|M.thermoresistible__bu      VR-------KADQSALVGGSDAQARDASAASTRDRLVLIPAILVVVLAVL
MMAR_1673|M.marinum_M               AS-------QASPSALVGGPDAQALDVRDAAEHDRALLIPAILAVILVVL
MUL_1909|M.ulcerans_Agy99           AS-------QASPSALVGGPDAQALDVRDAAEHDRALLIPAILAVILVVL
MAV_3895|M.avium_104                TR-------AADSGALVGGADAAALDVRDAATHDRVLLIPAILAVILIVL
MAB_0937c|M.abscessus_ATCC_199      AKGAQPNTTLADATISMGGFPTALRDTRDYYQHDIQFIIAATLIVVLLTL
Mb0208c|M.bovis_AF2122/97           LP-----RVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLML
Rv0202c|M.tuberculosis_H37Rv        LP-----RVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLML
MLBr_02617|M.leprae_Br4923          LP-----KVPGAAHVNVGGPTALINDFDDRVAKTEPLMLVFVALIAFVML
                                                    :**  :   *          .::     : :  *

Mflv_0224|M.gilvum_PYR-GCK          YVLLRSALAPLVLVGVTVLSSVAALG-------LGGWASVHLFGFPALDN
Mvan_0683|M.vanbaalenii_PYR-1       YLLLRSALAPLVLVGVTVLSALAALG-------LGGWASVHVFGFPALDY
MSMEG_0763|M.smegmatis_MC2_155      YILLRSAFAPLLLVGVTVLSSLAALG-------LGGWASVHIFGFPALDN
TH_3700|M.thermoresistible__bu      YVLLRAALAPLVLVAVSLLSSLAALG-------LGGWISVHVFGFPALDF
MMAR_1673|M.marinum_M               YALLRSALAPLILLAATILGALAALG-------LGGWASIHVFGFPALDN
MUL_1909|M.ulcerans_Agy99           YALLRSALAPLILLAATILGALAALG-------LGGWASIHVFGFPALDN
MAV_3895|M.avium_104                AVLLRSVMAPPVLLVATMLGALGALG-------LGGWVSLHLFGFPALDY
MAB_0937c|M.abscessus_ATCC_199      MVLLRAIVAPLYLVGSVVLSYFAAIG-------IGVLTFQYLLG-EQLHW
Mb0208c|M.bovis_AF2122/97           LISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDS
Rv0202c|M.tuberculosis_H37Rv        LISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDS
MLBr_02617|M.leprae_Br4923          LISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWLENLGFTHINSIDS
                                       :*: . .   :   :*.  .* *        *      .     :. 

Mflv_0224|M.gilvum_PYR-GCK          TAPLFAFLFLVALGVDYTIFLVTRAREETPGHG-TRDGIVRAVSATGAVI
Mvan_0683|M.vanbaalenii_PYR-1       TAPLFAFLFLVALGVDYTIFLVTRAREETPEHG-TRDGIVRAVSATGAVI
MSMEG_0763|M.smegmatis_MC2_155      GTPLFAFLFLVALGVDYTIFLVTRAREETPQYG-NREGIVRAVSATGAVI
TH_3700|M.thermoresistible__bu      ATPLFALLFLVALGVDYTIFLVTRAREETVGHG-TRGGIVRAVSATGAVI
MMAR_1673|M.marinum_M               STPLFAFLFLAALGVDYTIFLVTRAREESARNG-ARAGMVRAVSATGGVI
MUL_1909|M.ulcerans_Agy99           STPLFAFLFLAALGVDYTIFLVTRAREESARNG-ARAGMVRAVSATGGVI
MAV_3895|M.avium_104                TTPLFAFLFLAALGVDYTIFLVARAREEAARHG-TRQGMVEAVAATGGVI
MAB_0937c|M.abscessus_ATCC_199      TVPPLAFVVLVAVGADYNMLFVSRMRDESASS--VRYGIIRALNSTGGVI
Mb0208c|M.bovis_AF2122/97           TVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTI
Rv0202c|M.tuberculosis_H37Rv        TVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTI
MLBr_02617|M.leprae_Br4923          TVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGHTRDAVAYGVSTSARTI
                                     .* :.: .  .:. ** :::::* *:.       * .:  .: ::. .*

Mflv_0224|M.gilvum_PYR-GCK          SSAGIVLAAVFCVLGVLPLIVLTQVGIIVGLGILLDTFLVRTVIIPALFT
Mvan_0683|M.vanbaalenii_PYR-1       TSAGIVLAAVFCVLGVLPLIVLTQVGIIVGLGILLDTFVVRTVIIPALFT
MSMEG_0763|M.smegmatis_MC2_155      TSAGVVLAAVFCVLGVLPLIVLTQLGIIVGLGILLDTFLVRTVIIPALFT
TH_3700|M.thermoresistible__bu      TSAGIVLAAVFCVLGVLPLIVLTQLGIIVGLGILLDTFVVRTVVVPALFT
MMAR_1673|M.marinum_M               TSAGIVLAAVFCVLAVLPLIVLTQLGIIVGLGILLDTFVVRTLVIPALFT
MUL_1909|M.ulcerans_Agy99           TSAGIVLAAVFCVLAVLPLIVLTQLGIIVGLGILLDTFVVRTLVIPALFT
MAV_3895|M.avium_104                TSAGIVLAAVFCVLAVLPLMVLTQLGIIVGLGILLDTFVVRTLVIPALFT
MAB_0937c|M.abscessus_ATCC_199      TAAGLIFAASVGGLLFSSIGIVVQGGFVIGVGILLDTFVVRTITVPAIAA
Mb0208c|M.bovis_AF2122/97           TSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMA
Rv0202c|M.tuberculosis_H37Rv        TSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMA
MLBr_02617|M.leprae_Br4923          TSAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDVTAVRLVLVPTLMA
                                    ::*.::: * .  : .  : ::.: *.  .:.* :*.  ** : :*:: :

Mflv_0224|M.gilvum_PYR-GCK          LIGPKIWWPALRQETRSDA-------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       LIGPRIWWPALREDGPSRGR------------------------------
MSMEG_0763|M.smegmatis_MC2_155      WIGPKIWWPGLRAEP-----------------------------------
TH_3700|M.thermoresistible__bu      LIGPRMWWPALRAAE-----------------------------------
MMAR_1673|M.marinum_M               LIGDRIWWPSDPKTTAHQPDLAYSHADGGSE-------------------
MUL_1909|M.ulcerans_Agy99           LIGDRIWWPSDPKTTAHQPDLAYSHADGGSE-------------------
MAV_3895|M.avium_104                LVGDRIWWPNNP--SRHERSTP----------------------------
MAB_0937c|M.abscessus_ATCC_199      LVGKANWWPSQVNARQTSSAKPSAAAPAG---------------------
Mb0208c|M.bovis_AF2122/97           MFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSAD
Rv0202c|M.tuberculosis_H37Rv        MFDRWNWWLPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSAD
MLBr_02617|M.leprae_Br4923          MFAQWNWWLPRWLSRALPAVDFDKPFPPVDLNEIVVLPADISATKVPCGD
                                     .    **                                          

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0208c|M.bovis_AF2122/97           VRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQ---------
Rv0202c|M.tuberculosis_H37Rv        VRMVLKSAAKLKRLAPDAICVTDPLAFTGCGCDGKALDQVQ---------
MLBr_02617|M.leprae_Br4923          LRMVLKLAAKLKNLAPDAICVADPLAFTGCGRNNKRSDRVLPGAATQESE
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0208c|M.bovis_AF2122/97           --------------------------------------LAYRNGIARAIS
Rv0202c|M.tuberculosis_H37Rv        --------------------------------------LAYRNGIARAIS
MLBr_02617|M.leprae_Br4923          EDPAMGKASDSTAALTAAQVGPVTRTNGHWTARNLVIGLTHRNSITRVMP
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0208c|M.bovis_AF2122/97           WGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVET
Rv0202c|M.tuberculosis_H37Rv        WGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPVET
MLBr_02617|M.leprae_Br4923          WSDRPVHPFTLWRSRFSVAIDALEAHIAVQADAPDQ---PNYQRCSPVET
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0208c|M.bovis_AF2122/97           TNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPET
Rv0202c|M.tuberculosis_H37Rv        TNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPET
MLBr_02617|M.leprae_Br4923          AHVQLPTGDRLLIPTGAETLRLVSYLIMCRNSIRDYAELADMVDAIEPET
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0683|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0763|M.smegmatis_MC2_155      --------------------------------------------------
TH_3700|M.thermoresistible__bu      --------------------------------------------------
MMAR_1673|M.marinum_M               --------------------------------------------------
MUL_1909|M.ulcerans_Agy99           --------------------------------------------------
MAV_3895|M.avium_104                --------------------------------------------------
MAB_0937c|M.abscessus_ATCC_199      --------------------------------------------------
Mb0208c|M.bovis_AF2122/97           AAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGD-QSPGADAQA
Rv0202c|M.tuberculosis_H37Rv        AAAVLAGMDRYYSCQAPGRQWMATQLVGRLADPQPSDLGD-QSPGADAQA
MLBr_02617|M.leprae_Br4923          AAVVLTELDRYYSCQLPMRQWMATQLVRRLSDPHPVDLTEDQWSDPDNKA
                                                                                      

Mflv_0224|M.gilvum_PYR-GCK          ---------------------
Mvan_0683|M.vanbaalenii_PYR-1       ---------------------
MSMEG_0763|M.smegmatis_MC2_155      ---------------------
TH_3700|M.thermoresistible__bu      ---------------------
MMAR_1673|M.marinum_M               ---------------------
MUL_1909|M.ulcerans_Agy99           ---------------------
MAV_3895|M.avium_104                ---------------------
MAB_0937c|M.abscessus_ATCC_199      ---------------------
Mb0208c|M.bovis_AF2122/97           KWEEVRRRCLSVAVAMLEEAR
Rv0202c|M.tuberculosis_H37Rv        KWEEVRRRCLSVAVAMLEEAR
MLBr_02617|M.leprae_Br4923          EWQDVRQRCLSVAVAMLEEAR