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M. tuberculosis H37Rv Rv0202c (mmpL11)

annotation: PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11
coordinates: 238392 - 241292
length: 966

MRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALV
AAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRI
GVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAV
CTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLA
VVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPA
STQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGA
LGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDT
ITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTL
LSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDA
VAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWW
LPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFT
GCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRR
SPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQ
APGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv0202cmmpL11-100% (966)PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11
M. tuberculosis H37RvRv0206cmmpL31e-4924.88% (816) transmembrane transport protein MmpL3
M. tuberculosis H37RvRv1146mmpL13b2e-3830.96% (436) transmembrane transport protein MmpL13B

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0208cmmpL110.0100.00% (966) transmembrane transport protein MmpL11
M. gilvum PYR-GCKMflv_0464-0.068.39% (984) MmpL11
M. leprae Br4923MLBr_02617-0.072.57% (1017) hypothetical protein MLBr_02617
M. abscessus ATCC 19977MAB_4529-0.054.47% (973) putative membrane protein, MmpL
M. marinum MMMAR_0442mmpL110.078.54% (1011) transmembrane transport protein MmpL11
M. avium 104MAV_4973-0.075.57% (1015) MmpL11 protein
M. smegmatis MC2 155MSMEG_0241-0.069.04% (969) MmpL11 protein
M. thermoresistible (build 8)TH_3087-0.067.79% (981) PUTATIVE MmpL11
M. ulcerans Agy99MUL_1092mmpL110.078.14% (1011) transmembrane transport protein MmpL11
M. vanbaalenii PYR-1Mvan_0188-0.069.33% (978) MmpL11

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0464|M.gilvum_PYR-GCK          MMRVSSNLRRFRWAVFAVWLLLLLPSVYLAMNQAGNLTGGGFEVEGSQSL
Mvan_0188|M.vanbaalenii_PYR-1       MLRVSSNLRRFRWAVFAVWLLLLVPSIYLALNQSSHLTGGGFEVEGSQSL
MSMEG_0241|M.smegmatis_MC2_155      MMRLSSTLRRFRWAVFATWLLLLVPSIYLALNQSSNLTGGGFEVEGSQSL
TH_3087|M.thermoresistible__bu      MMRLSNALRRYRWAVFSGWVLLLLPSIWLALSGTGQLTGGGFEVAGSQSL
Rv0202c|M.tuberculosis_H37Rv        MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSL
Mb0208c|M.bovis_AF2122/97           MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSL
MMAR_0442|M.marinum_M               MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAGSQSL
MUL_1092|M.ulcerans_Agy99           MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAGSQSL
MAV_4973|M.avium_104                MMRLSRSLRKYRWLVFAGWLLALVPAVYLALTQSGNLTGGGFDVAGSQSL
MLBr_02617|M.leprae_Br4923          -MRLSSYLRRFRWLVFTGWLLALVPAIYLAMTQSGKLTGGGFEVAGSQSL
MAB_4529|M.abscessus_ATCC_1997      MMRTSDYLRRYRWLTVAVWLILIVAAVGLVAGRGEKLTGGGFEVAGSQSL
                                     :* *  **: ** ..: *:: ::.:: *.     :******:* *****

Mflv_0464|M.gilvum_PYR-GCK          YVQRQLEAQFPDQGASPLALVAAPRPDASFEDMNNAVAQLESLAAEIP-S
Mvan_0188|M.vanbaalenii_PYR-1       YVQRQLEAQFPDQGASPLALVAAPRSDASYDDMTSAVSHLERLAAEVP-S
MSMEG_0241|M.smegmatis_MC2_155      HVQRQLEEHFPDQGASPLALVAAPRADASYEDMNAAVVHLEKLAAEVP-S
TH_3087|M.thermoresistible__bu      RVQHELEDHFPDEGASPLALVAAPRADATFEDMNAAVAFLEQVAAEVSDD
Rv0202c|M.tuberculosis_H37Rv        LVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELP-G
Mb0208c|M.bovis_AF2122/97           LVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELP-G
MMAR_0442|M.marinum_M               QVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGEFP-G
MUL_1092|M.ulcerans_Agy99           RVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGEFP-G
MAV_4973|M.avium_104                AVHDQLEDLYHDQGGSSLALVAAPRADASYQDMNDAVAQLRRIAAEVP-G
MLBr_02617|M.leprae_Br4923          LVHDQLQEQYPDQGAVSLALVAAPRSDASYQDMNDAVALLRRIVSEFP-G
MAB_4529|M.abscessus_ATCC_1997      KVHDAMETGFREQGASPLALVAAPRPDATVSDMAAAVDYLKQVAAQIP-Q
                                     *:  ::  : :.*. .*****:**.**: .*:  **  *. :..:..  

Mflv_0464|M.gilvum_PYR-GCK          ITVVPSPQQPPPQPDRPYVVTLAMDFENTGAVDIAKQLREKVGVDGEDAG
Mvan_0188|M.vanbaalenii_PYR-1       VTVVPTPQQPPPRPDRPYVITLQLDFENTGAVDVAKQLREKVGVDGEEPG
MSMEG_0241|M.smegmatis_MC2_155      VKIVPNPQQPAPQPDRPYVITLQLDFNNTGAVDVAKQLRQKVGIHGEEPG
TH_3087|M.thermoresistible__bu      VRIKPNPQQPPPRPDRPYVLTLQLDFDNTGAVDVSNQLREKVGIDGDRPG
Rv0202c|M.tuberculosis_H37Rv        VTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSG
Mb0208c|M.bovis_AF2122/97           VTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSG
MMAR_0442|M.marinum_M               VSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVGVEGDKPG
MUL_1092|M.ulcerans_Agy99           VSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVGVEGDKPG
MAV_4973|M.avium_104                TTEIPNPTQRPPQPDRPYVLSVRLDSRN--TSDVAKQLRTKVGIKGDQPG
MLBr_02617|M.leprae_Br4923          VSEVPNPTQLPPRPDRPYGVSLRLDDRNSVTSDVAKQLRTKVGIKGDQAG
MAB_4529|M.abscessus_ATCC_1997      VSVEPIPPQLTPQPDRPFVVTLRIGFDNTGATDIAKSLRKKIGVHGGQPG
                                        * * * .*:****: ::: :.  *  : *:::.** ::*:.*  .*

Mflv_0464|M.gilvum_PYR-GCK          ETENGKVRLYVIGQGALGAAATEATKDDIAQAEKWNFPIVLVILLAVFGS
Mvan_0188|M.vanbaalenii_PYR-1       EMENGKVRLYVIGQGALGAAATLATKHDIAQAEKWNFPIVLVILLAVFGS
MSMEG_0241|M.smegmatis_MC2_155      ESQNGKVKFYVIGQGALGAAATQATKHDIAAAEKWNMPIVLIVLLAVFGS
TH_3087|M.thermoresistible__bu      ETDNGRVRLYVVGQGALGAAASEATKHDIAQAERWNLPIVLIILLAVFGS
Rv0202c|M.tuberculosis_H37Rv        QTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGS
Mb0208c|M.bovis_AF2122/97           QTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGS
MMAR_0442|M.marinum_M               QTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIVLLAVFGS
MUL_1092|M.ulcerans_Agy99           QTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIVLLAVFGS
MAV_4973|M.avium_104                QTANGRVRLYVIGQGALSAAAAANTKHDIAAAEKWNLPVILIVLLAVFGS
MLBr_02617|M.leprae_Br4923          RTANGKVRLYVIGQGALSAAVAANSKHDIAEAERWNLPIILIVLLAVFGS
MAB_4529|M.abscessus_ATCC_1997      QIAGGRVSLYVIGQGALGAAMTEQIAGDIKKAEKWNIPVILIVLIAAFGS
                                    .  .*:* :**:*****.** :     **  **:**:*::*::*:*.***

Mflv_0464|M.gilvum_PYR-GCK          LAAAAMPLLLGVCTVVVTMGVVFVLSMYTTMSVFVTSTVSMFGIAVAIDY
Mvan_0188|M.vanbaalenii_PYR-1       LAAAAMPLLLGVCTVVVTMGLVFLLSMYTTMSVFVTSTVSMFGIAVAIDY
MSMEG_0241|M.smegmatis_MC2_155      LAAAALPLVLGVCTVVVTMGLVYLLSMFTTMSVFVTSTVSMFGIAVAIDY
TH_3087|M.thermoresistible__bu      LAAAAVPLVLGVCTVVVTMGVVYLLSLVTTMSVFVASTVSMLGIALAIDY
Rv0202c|M.tuberculosis_H37Rv        LAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDY
Mb0208c|M.bovis_AF2122/97           LAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDY
MMAR_0442|M.marinum_M               LTAAAIPLALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFGIALAVDY
MUL_1092|M.ulcerans_Agy99           LTAAAIALALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFGIALAVDY
MAV_4973|M.avium_104                LAAAAIPLALGICTVVVTMGLVYLLSAYTTMSVFVTSTVSMFGIALAVDY
MLBr_02617|M.leprae_Br4923          LAAAAVPLALGVCTVVVTMGLVDLVSMHTIMSVFVTSTVSMFGIALAVDY
MAB_4529|M.abscessus_ATCC_1997      LAAASLPLLLGVCTVALSVAIVLALSNITTISVFALPTVTMIGLAVAVDY
                                    *:**::.* *.:***.:::.:*  :*  * :***. .**:*:*:*:*:**

Mflv_0464|M.gilvum_PYR-GCK          SLFILMRFREELRAGREPEDAADAAMATSGLAVVLSGLTVIASVTGIYLI
Mvan_0188|M.vanbaalenii_PYR-1       SLFILMRFREELRAGREPEDAADAAMATSGLAVLLSGLTVIASVTGIYLI
MSMEG_0241|M.smegmatis_MC2_155      SLFILMRFREELRAGRDQQDAIDAAMATSGLAVALSGLTVIASVTGIYLI
TH_3087|M.thermoresistible__bu      SLFILMRFREELRAGRDVDQAADAAMATSGLAVVLSGLTVIASVTGLYLI
Rv0202c|M.tuberculosis_H37Rv        SLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLI
Mb0208c|M.bovis_AF2122/97           SLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLI
MMAR_0442|M.marinum_M               SLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVVASLSGIYLI
MUL_1092|M.ulcerans_Agy99           SLFILMRFREELRSGRQPQEAADAAMATSGLAVVLSGMTVVASLSGIYLI
MAV_4973|M.avium_104                SLFILMRFREELRSGRQPREAVDAAMATSGLAVVLSGMTVIASLTGIYVI
MLBr_02617|M.leprae_Br4923          SLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVIASLTGIYLI
MAB_4529|M.abscessus_ATCC_1997      SLFILMRYREELNSGKNRQEAIAGAMATSGLTVTFSGLTVIAALAGIYLI
                                    *******:****..*:   :*  .*******:* :**:**:*:::*:*:*

Mflv_0464|M.gilvum_PYR-GCK          NTPVLQSMATGAILAVAIAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRG
Mvan_0188|M.vanbaalenii_PYR-1       NTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRG
MSMEG_0241|M.smegmatis_MC2_155      NTPVLVSMATGAILAVAVAVLTSTTLTPAVLATFGKAAAKRSSYLHWSRR
TH_3087|M.thermoresistible__bu      NTPVLRSMATGAVLAVAVAVLAATTLTPAVLATFGRAAARRSSYLHWSRR
Rv0202c|M.tuberculosis_H37Rv        NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRR
Mb0208c|M.bovis_AF2122/97           NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRR
MMAR_0442|M.marinum_M               NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALLHWSRR
MUL_1092|M.ulcerans_Agy99           NTPALRSMATGAILAVAVAILTSATLTPAVLATFARAAAKRSALLHWSRR
MAV_4973|M.avium_104                NTPALKSMATGAILAVAVAMLTSTTLTPAALATFGRAAAKRSALLHWSRR
MLBr_02617|M.leprae_Br4923          NTAALKSMATGAILAVAIAMLASITLTPAALATFGRAAVKRSVLMHWSQR
MAB_4529|M.abscessus_ATCC_1997      GTPALASMASGAIIVVAIAVLTSTTLMPALLAIFGKAAANQSRFLRVSP-
                                    .*..* ***:**::.**:*:*:: ** ** ** *.: *..:*  :: .  

Mflv_0464|M.gilvum_PYR-GCK          VEATQSKFWTRWTGWVMRRPWLSAMAAAAVLLTFAAPAFSMMLGNSMQRQ
Mvan_0188|M.vanbaalenii_PYR-1       VEATQSKFWSRWTGWVMRRPWVSATAAAAVLLAFAAPAFSMMLGNSMQRQ
MSMEG_0241|M.smegmatis_MC2_155      AEAAQSRFWTRWTGAVMRRPWASAIAAAILLLVLAAPAFNMVLGNSMQRQ
TH_3087|M.thermoresistible__bu      PETTQSPFWTRWTGQVMRRPWVSAAAASAVLLVMAAPTVAMELGNSMQRQ
Rv0202c|M.tuberculosis_H37Rv        PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ
Mb0208c|M.bovis_AF2122/97           PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ
MMAR_0442|M.marinum_M               PESTQSRFWTRWVGWVMHRPWITALSASVVLLLMAAPAASMVLGNSLLRQ
MUL_1092|M.ulcerans_Agy99           PESTQSRFWTRWVGWVMHRPWITALSASVVLLLMAAPAASMVLGNSLLRQ
MAV_4973|M.avium_104                PESTQSKFWNRWIGWVMRRPWMSALAASLVLLVMAAPAASMVLGNSLLRQ
MLBr_02617|M.leprae_Br4923          SECTQSLFWTRWVGWVMHRPWISASAASTILIIMATPVTSMMLGNSLLRQ
MAB_4529|M.abscessus_ATCC_1997      LRKHSIPFWRKWTQQVMRRPWLSALGASIFLLALAAPSLQMHVSNSMLRQ
                                        .  ** :*   **:*** :* .*: .*: :*:*   * :.**: **

Mflv_0464|M.gilvum_PYR-GCK          FDTTHEIRGGVSAAAEALGPGALGPIRVLITFPDGD--AASASAKEPLLA
Mvan_0188|M.vanbaalenii_PYR-1       FDPTHEIRGGVNAAAEALGPGALGPIRVLVTFPVDD--GAEAAA--PLLE
MSMEG_0241|M.smegmatis_MC2_155      FDPTHEIRGGVNAAADALGPGALGPIRVLVTFPGEG--DASSQAATTTIE
TH_3087|M.thermoresistible__bu      FEPTHEIRGGVNAAAEALGPGALGPVRVMVSFP-DG--AASQPANAGTLD
Rv0202c|M.tuberculosis_H37Rv        FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---GASAPEHSQTIA
Mb0208c|M.bovis_AF2122/97           FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---GASAPEHSQTIA
MMAR_0442|M.marinum_M               FDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG---GASTPAHSQTVG
MUL_1092|M.ulcerans_Agy99           FDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG---GASTPAHSQTVG
MAV_4973|M.avium_104                FDSSHEIRAGVGAAAQALGPGALGPIRVLINFPDG---GAASPEHSHTVG
MLBr_02617|M.leprae_Br4923          FNSSHEIRAGVAAAAQALGPGALGPVQVLITFPDDPNTQASSPKHRQTIG
MAB_4529|M.abscessus_ATCC_1997      FDSSHEIRRGIDAAAVAMGPGALGPVQVLLTFKDSP-----AHAHAQALE
                                    *:.:**** *  *** *:*******::*:: *                : 

Mflv_0464|M.gilvum_PYR-GCK          ELRQTMAGAPNVVSVTPPVFGTDYRIALLSAVLSVDPEDMGARETIDWMR
Mvan_0188|M.vanbaalenii_PYR-1       SLRQKMGQAPNTVSVSPPVFGSDGRSALLSAVLSVDPEDMGARDTVDWMR
MSMEG_0241|M.smegmatis_MC2_155      AVRQQMTKAPSVVSVQPPVVSDDNDSALLSAVLSVDPEDMAAREAIDWMR
TH_3087|M.thermoresistible__bu      AVRQEISRAPNVVSVSPPVFADDDSSALLSAVLSVDPEDMRARDTIDWLR
Rv0202c|M.tuberculosis_H37Rv        AIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMR
Mb0208c|M.bovis_AF2122/97           AIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMR
MMAR_0442|M.marinum_M               AVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSVDPEDMGARHTVDWMR
MUL_1092|M.ulcerans_Agy99           AVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSVDPEDMGARHTVDWMR
MAV_4973|M.avium_104                AVRQRMAQAPNIVSVSPPQFAEDNGSALLSAVLSVDPEDMKARETVGWMR
MLBr_02617|M.leprae_Br4923          AIRNRMLQAKNVMSVAPPQFADNNCSALLGAVLSVDPEDLGARETVDWMR
MAB_4529|M.abscessus_ATCC_1997      TAKETIAQAPNIARVSDVSFSTDGHDALISAVLSVDPEANAARDTVSWLR
                                      :. :  . .   *    .. :   **:.********   **.:: *:*

Mflv_0464|M.gilvum_PYR-GCK          EKLPPVA-GDAASIDVGGPTALIKDFDDKVSATQPLVFAFVALIAFVMLL
Mvan_0188|M.vanbaalenii_PYR-1       EQLPPVA-GDAARVDVGGPTALIKDFDDRVSQTQPLVFVFVALIAFVMLL
MSMEG_0241|M.smegmatis_MC2_155      AELPGVA-GQNATIDVGGPTALIKDFDDRVSATQPLVFVFVALIAFVMLL
TH_3087|M.thermoresistible__bu      EHLPAAA-GDGARTDVGGPTALIKDFDDEVATTQPLVFVFVAVIAFVMLL
Rv0202c|M.tuberculosis_H37Rv        TQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLL
Mb0208c|M.bovis_AF2122/97           TQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLL
MMAR_0442|M.marinum_M               SELPQV--AGGAQVDVGGSTALIKDFDDRVSATEPLVLAFVALIAFVMLL
MUL_1092|M.ulcerans_Agy99           SELPQV--AGGAQFDVGGSTALIKDFDDRVSATEPLVLAFVALIAFVMLL
MAV_4973|M.avium_104                AELPKVSEAGTARVDVGGPTALIKDFDDRVSATEPLVLGFVALIAFVMLL
MLBr_02617|M.leprae_Br4923          TELPKV--PGAAHVNVGGPTALINDFDDRVAKTEPLMLVFVALIAFVMLL
MAB_4529|M.abscessus_ATCC_1997      ANVPDALENSGADINVGGPTALLFDYDTRVEHSLLGVFAFVCVLAFVMLL
                                     .:* .     *  :***.***: *:* .*  :   :: **.::**:***

Mflv_0464|M.gilvum_PYR-GCK          VSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGWLSSLGFDQLSSLDST
Mvan_0188|M.vanbaalenii_PYR-1       VSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGWLADLGFKQISSLDST
MSMEG_0241|M.smegmatis_MC2_155      VSIRSVVLAFKGVLMTVLSVAAAYGSLVVVFQWGWLEQLGFPRISSLDST
TH_3087|M.thermoresistible__bu      IAIRSPVLALKGVLMTVLSVAAAYGSLVAVFQWGWLAPLGFEPISSLDST
Rv0202c|M.tuberculosis_H37Rv        ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDST
Mb0208c|M.bovis_AF2122/97           ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDST
MMAR_0442|M.marinum_M               ISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGWGERLGFPQLTSIDST
MUL_1092|M.ulcerans_Agy99           ISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGWGERLGFPQLTSIDST
MAV_4973|M.avium_104                VSIHSVFLALKGVLMTLLSVAAAYGSLVMVFQWGWLRDLGFAQISSIDST
MLBr_02617|M.leprae_Br4923          ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWLENLGFTHINSIDST
MAB_4529|M.abscessus_ATCC_1997      ATLRSPVLALKGVVMTVLSVAAAYGSLVIVFQWGWLEFLGFHKAN-IDSS
                                     :::* .**:***:**:*********** ******   ***     :**:

Mflv_0464|M.gilvum_PYR-GCK          IPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTIT
Mvan_0188|M.vanbaalenii_PYR-1       IPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTIT
MSMEG_0241|M.smegmatis_MC2_155      IPPLVLAMTFGLSMDYEIFLLTRIRERFLQTNSTRDAVAYGVSTSARTIT
TH_3087|M.thermoresistible__bu      IPPLVLALTFGLSMDYEIFLLTRIRERFLQTQDTRDAVAYGVSTSARTIT
Rv0202c|M.tuberculosis_H37Rv        VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT
Mb0208c|M.bovis_AF2122/97           VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT
MMAR_0442|M.marinum_M               VPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGRTRDAVAYGVSTSARTIT
MUL_1092|M.ulcerans_Agy99           VPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGRTRDAVAYGVSTSARTIT
MAV_4973|M.avium_104                VPPLVLAMTFGLSMDYEIFLLTRIRERFLHSGNTRDAVAYGVSTSARTIT
MLBr_02617|M.leprae_Br4923          VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGHTRDAVAYGVSTSARTIT
MAB_4529|M.abscessus_ATCC_1997      IPPLALALTFGLTMDYEIFLLARVRERYLRTGDCGDAVSYGVRTSARTIT
                                    :***.**:****:********:*:***:*::    ***:*** *******

Mflv_0464|M.gilvum_PYR-GCK          SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAM
Mvan_0188|M.vanbaalenii_PYR-1       SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAM
MSMEG_0241|M.smegmatis_MC2_155      SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM
TH_3087|M.thermoresistible__bu      SAALIMIAVFTGFAFAGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM
Rv0202c|M.tuberculosis_H37Rv        SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM
Mb0208c|M.bovis_AF2122/97           SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM
MMAR_0442|M.marinum_M               SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATIVRLIMVPALMAM
MUL_1092|M.ulcerans_Agy99           SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATIVRLIMVPALMAM
MAV_4973|M.avium_104                SAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDATVVRLVMVPALMAM
MLBr_02617|M.leprae_Br4923          SAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDVTAVRLVLVPTLMAM
MAB_4529|M.abscessus_ATCC_1997      SAALIMIAVFIGFAFVGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM
                                    ********** ****.******::***********.* ***::**:****

Mflv_0464|M.gilvum_PYR-GCK          FDEWNWWLPRWLDRLLPSVDFEKPLPKADIG--DLVIIPDDISALAPSGS
Mvan_0188|M.vanbaalenii_PYR-1       FDEWNWWLPRWLDRILPSVDFEKPLPKADIG--DLVIIPDDISALAPSGS
MSMEG_0241|M.smegmatis_MC2_155      FDQWNWWLPRWLDKILPEVDFEKPLPKIEVT--DLVIIPDNIAALGPSGS
TH_3087|M.thermoresistible__bu      FDKWNWWLPPWLDRLLPSVDFEKPLPHTDIG--DLVIIPDDISALMPPGS
Rv0202c|M.tuberculosis_H37Rv        FDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--DVVVIPDDFAAAIPPSA
Mb0208c|M.bovis_AF2122/97           FDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--DVVVIPDDFAAAIPPSA
MMAR_0442|M.marinum_M               FSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--DVVVIPEDIAATIPPGA
MUL_1092|M.ulcerans_Agy99           FSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--DVVVIPEDIAATIPPGA
MAV_4973|M.avium_104                FAQWNWWLPPWLSRVLPSVDFDRPLPEVDLG--DVVVIPDDISALTAPSA
MLBr_02617|M.leprae_Br4923          FAQWNWWLPRWLSRALPAVDFDKPFPPVDLN--EIVVLPADISATKVPCG
MAB_4529|M.abscessus_ATCC_1997      FDKRNWWLPGWLDHVLPTVDFETPCVDELPGPHSESALRLQGSGFEEPRI
                                    * . ***** ** : ** ***: *         .   :  : :.   .  

Mflv_0464|M.gilvum_PYR-GCK          DLRTVVKSAAKLKTLVP-QAVTVADPLAFSGCLPCNKMTGTRV-------
Mvan_0188|M.vanbaalenii_PYR-1       DLRTVVKSAAKLKTLAP-QAITVADPLAFSGCLPCGKISGNRV-------
MSMEG_0241|M.smegmatis_MC2_155      DLRTMVRTAARMKTLAP-QTISVADPLAFSGCT-----------------
TH_3087|M.thermoresistible__bu      QLRSVVRSAAKLKSLAP-ETITVADPLAFSGCVRSGEPLGPRIK------
Rv0202c|M.tuberculosis_H37Rv        DVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGCDGK-------------
Mb0208c|M.bovis_AF2122/97           DVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGCDGK-------------
MMAR_0442|M.marinum_M               DLRMVLKSAAKLKQLAP-DTICVADPLAFTGCERVGKGPERIPELVKDG-
MUL_1092|M.ulcerans_Agy99           DLRMVLKSAAKLKQLAP-DTICVADPLAFTGCEGVGKGPERIPELVKDG-
MAV_4973|M.avium_104                DLRMVLKSAAKLKHLAP-DAICVTDPLAFTGCGRTTAAGADPARGLGPGQ
MLBr_02617|M.leprae_Br4923          DLRMVLKLAAKLKNLAP-DAICVADPLAFTGCGRNNKRSDRVLPGAATQE
MAB_4529|M.abscessus_ATCC_1997      DYHAIAVSAARLKRLADGGTITAPDTQAVLADR-----------------
                                    : : :   **::* *.   :: ..*. *. .                   

Mflv_0464|M.gilvum_PYR-GCK          --------------------------GRDERITAAVSN----RAHGKTVA
Mvan_0188|M.vanbaalenii_PYR-1       --------------------------GRDERITAAVTN----RAHGKTVA
MSMEG_0241|M.smegmatis_MC2_155      ------------------------------RPTTRLST----QRAGRPKA
TH_3087|M.thermoresistible__bu      --------------------------GGDDGTTVPVRTGGGGRRAGTAVA
Rv0202c|M.tuberculosis_H37Rv        ---------------------------------ALDQVQ-LAYRNGIARA
Mb0208c|M.bovis_AF2122/97           ---------------------------------ALDQVQ-LAYRNGIARA
MMAR_0442|M.marinum_M               ------LNLAGGTDTAGPGGAAEAKNGSNGQSAARKAVG-LAYRSGIARA
MUL_1092|M.ulcerans_Agy99           ------LNLAGGTDTAGPGGGAEAKNGSKGQSAARKAVG-LAYRSGIARA
MAV_4973|M.avium_104                IPHQVALREEKVGVAAGPGEKTGSNGHTNGSAGAKKPAA-RNGRNGIAKA
MLBr_02617|M.leprae_Br4923          SEEDPAMGKASDSTAALTAAQVGPVTRTNGHWTARNLVIGLTHRNSITRV
MAB_4529|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

Mflv_0464|M.gilvum_PYR-GCK          VKLP---KHPVTMWRGRLDVALEALATER------AQNEGHPTIERISPL
Mvan_0188|M.vanbaalenii_PYR-1       VKLP---KHPVTMWRGRLDVALDALAVEQ------SAGNGEPRIERISPM
MSMEG_0241|M.smegmatis_MC2_155      HTPG---LHPVTMWRGRLSVAVDALQTEA------DTEQAP--VERRGPV
TH_3087|M.thermoresistible__bu      TRPA---VHPVTLWLDRLEVALDALHTAA------DLDGAP--VERRSPM
Rv0202c|M.tuberculosis_H37Rv        ISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPV
Mb0208c|M.bovis_AF2122/97           ISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPV
MMAR_0442|M.marinum_M               MSWAERPVHPVTVWRGRLSIALDALETNASERRAGPGGGREPSYRRRSPV
MUL_1092|M.ulcerans_Agy99           MSWAERPVHPVTVWRGRLSIALDALETNASERRAGPGSGREPNYRRRSPV
MAV_4973|M.avium_104                IAGADRPVHPVTLWRGRLSVALDALQTDP------DSGADRPRFRRRSPV
MLBr_02617|M.leprae_Br4923          MPWSDRPVHPFTLWRSRFSVAIDALEAHIAVQ---ADAPDQPNYQRCSPV
MAB_4529|M.abscessus_ATCC_1997      -------------WRDNLTVALEALQTSK-NGTDTDIVEMPGPLSRVTPV
                                                 *  .: :*::** .                  *  *:

Mflv_0464|M.gilvum_PYR-GCK          ETTNVLLPTGDRLQIPTGAETLRLKSYLILERNSTRDFSEFSELVDSMDT
Mvan_0188|M.vanbaalenii_PYR-1       ETTNVLLPTGDRLQIPTGAETLRLKGFLIMSRNTARDYRDFTELVDSMDV
MSMEG_0241|M.smegmatis_MC2_155      ETTNVQLPTGDRLQIPTGAETLRLAGYLIMCRNTTKDFEDFARLVDLMDS
TH_3087|M.thermoresistible__bu      ETTTVQLPTGDRLQIPTGAETVRLMGYLIMCRNSARDYAEFADLVECMDA
Rv0202c|M.tuberculosis_H37Rv        ETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAP
Mb0208c|M.bovis_AF2122/97           ETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAP
MMAR_0442|M.marinum_M               ETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNSSRDYAELADMVEAMEP
MUL_1092|M.ulcerans_Agy99           ETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNSSRDYAELADMVEAMEP
MAV_4973|M.avium_104                ETTNVQLPTGDRLLVPTGAEALRLKGYLLMCRNSRRDYADFADMVDALEP
MLBr_02617|M.leprae_Br4923          ETAHVQLPTGDRLLIPTGAETLRLVSYLIMCRNSIRDYAELADMVDAIEP
MAB_4529|M.abscessus_ATCC_1997      EITQVKLPTGQKCVVPTDAEALRMQGLLLMRRNAERDYTEFARLASAMEP
                                    * : * ****::  :**.**::*: . *:: **: :*: ::: :.. :  

Mflv_0464|M.gilvum_PYR-GCK          STAAEVLASMDRYYSGQSARDQQAGARTRHWVATQLVRRLAEPAPADGPD
Mvan_0188|M.vanbaalenii_PYR-1       DTAADVLAGMDRYYAGQPAR--------AHWVATQLVRRLAEPLPSDGPD
MSMEG_0241|M.smegmatis_MC2_155      HTAALVLASMDRYYCGRDPS--------NRWVATQLVRRLADPQPSDEHD
TH_3087|M.thermoresistible__bu      ETAAAVLARMDRYYCGQYPR--------QHWVATQLVRRLADPHPSDVDD
Rv0202c|M.tuberculosis_H37Rv        ETAAAVLAGMDRYYSCQAPG--------RQWMATQLVGRLADPQPSD-LG
Mb0208c|M.bovis_AF2122/97           ETAAAVLAGMDRYYSCQAPG--------RQWMATQLVGRLADPQPSD-LG
MMAR_0442|M.marinum_M               ETAAVVLAGMDRYYCCQPPR--------RQWIATQLVRRLADPHPSD-VD
MUL_1092|M.ulcerans_Agy99           ETAAVVLAGMDRYYCCQPPR--------RQWIATQLVRRLADPHPSD-VD
MAV_4973|M.avium_104                ETAAVVLAGMDRYYCCESSR--------RQWIATQLVRRLADPDPCDYPD
MLBr_02617|M.leprae_Br4923          ETAAVVLTELDRYYSCQLPM--------RQWMATQLVRRLSDPHPVDLTE
MAB_4529|M.abscessus_ATCC_1997      RMAAKVLAGIDQHYCVQSNQ---------RWVSSQLVRRLADPKPGD---
                                      ** **: :*::*. .            :*:::*** **::* * *   

Mflv_0464|M.gilvum_PYR-GCK          IAAAGADGEAEWATVRQRCLSVAVAMLEETR
Mvan_0188|M.vanbaalenii_PYR-1       IAAAGADEETEWAKVRQRCLSVAVAMLEETR
MSMEG_0241|M.smegmatis_MC2_155      VRMSGPDAAEDWEKVRQRCLSVAVAMLEEAK
TH_3087|M.thermoresistible__bu      DGETESSAVADWDEVRKRCLSVAVAMLEEAR
Rv0202c|M.tuberculosis_H37Rv        DQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
Mb0208c|M.bovis_AF2122/97           DQSPGADAQAKWEEVRRRCLSVAVAMLEEAR
MMAR_0442|M.marinum_M               VEWPQPDDKADWEEVRQRCLAVAVAMLEEAR
MUL_1092|M.ulcerans_Agy99           VEWPQPDDKADWEEVRQRCLAVAVAMLEEAR
MAV_4973|M.avium_104                DQGPDADAPADWEQIRQRCLAVAVAMLEEAR
MLBr_02617|M.leprae_Br4923          DQWSDPDNKAEWQDVRQRCLSVAVAMLEEAR
MAB_4529|M.abscessus_ATCC_1997      -------GAMECPTVRRQCLSVAVAMLEDAR
                                              .   :*::**:*******:::