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MRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSLLVHDQLDAHYPDRGAPALALV AAPRPDASYQDIDNAVALLRQIASELPGVTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRI GVKGDQSGQTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGSLAAAAIPLALAV CTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDYSLFILMRYREELRCGRRPPDAVDAAMATSGLA VVLSGMTVIASLTGIYLINTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRRPA STQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQFDSSHEIRTGAAAAAQALGPGA LGPVQVLVRFDAGGASAPEHSQTIAAIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDT ITWMRTQLPRVAGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLLISIRSVFLAFKGVLMTL LSVAAAYGSLVMVFQWGWARGLGFPALHSIDSTVPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDA VAYGVRTSARTITSAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAMFDRWNWW LPRWLAHILPSVDFDRPLPKVDLGDVVVIPDDFAAAIPPSADVRMVLKSAAKLKRLAPDAICVTDPLAFT GCGCDGKALDQVQLAYRNGIARAISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRR SPVETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAPETAAAVLAGMDRYYSCQ APGRQWMATQLVGRLADPQPSDLGDQSPGADAQAKWEEVRRRCLSVAVAMLEEAR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0202c | mmpL11 | - | 100% (966) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11 |
M. tuberculosis H37Rv | Rv0206c | mmpL3 | 1e-49 | 24.88% (816) | transmembrane transport protein MmpL3 |
M. tuberculosis H37Rv | Rv1146 | mmpL13b | 2e-38 | 30.96% (436) | transmembrane transport protein MmpL13B |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0208c | mmpL11 | 0.0 | 100.00% (966) | transmembrane transport protein MmpL11 |
M. gilvum PYR-GCK | Mflv_0464 | - | 0.0 | 68.39% (984) | MmpL11 |
M. leprae Br4923 | MLBr_02617 | - | 0.0 | 72.57% (1017) | hypothetical protein MLBr_02617 |
M. abscessus ATCC 19977 | MAB_4529 | - | 0.0 | 54.47% (973) | putative membrane protein, MmpL |
M. marinum M | MMAR_0442 | mmpL11 | 0.0 | 78.54% (1011) | transmembrane transport protein MmpL11 |
M. avium 104 | MAV_4973 | - | 0.0 | 75.57% (1015) | MmpL11 protein |
M. smegmatis MC2 155 | MSMEG_0241 | - | 0.0 | 69.04% (969) | MmpL11 protein |
M. thermoresistible (build 8) | TH_3087 | - | 0.0 | 67.79% (981) | PUTATIVE MmpL11 |
M. ulcerans Agy99 | MUL_1092 | mmpL11 | 0.0 | 78.14% (1011) | transmembrane transport protein MmpL11 |
M. vanbaalenii PYR-1 | Mvan_0188 | - | 0.0 | 69.33% (978) | MmpL11 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0464|M.gilvum_PYR-GCK MMRVSSNLRRFRWAVFAVWLLLLLPSVYLAMNQAGNLTGGGFEVEGSQSL Mvan_0188|M.vanbaalenii_PYR-1 MLRVSSNLRRFRWAVFAVWLLLLVPSIYLALNQSSHLTGGGFEVEGSQSL MSMEG_0241|M.smegmatis_MC2_155 MMRLSSTLRRFRWAVFATWLLLLVPSIYLALNQSSNLTGGGFEVEGSQSL TH_3087|M.thermoresistible__bu MMRLSNALRRYRWAVFSGWVLLLLPSIWLALSGTGQLTGGGFEVAGSQSL Rv0202c|M.tuberculosis_H37Rv MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSL Mb0208c|M.bovis_AF2122/97 MMRLSRNLRRCRWLVFTGWLLALVPAVYLAMTQSGNLTGGGFEVAGSQSL MMAR_0442|M.marinum_M MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAGSQSL MUL_1092|M.ulcerans_Agy99 MMRLSRNLRRFRWLVFTGWMLALVPAIYLALTQSGNLTGGGFEVAGSQSL MAV_4973|M.avium_104 MMRLSRSLRKYRWLVFAGWLLALVPAVYLALTQSGNLTGGGFDVAGSQSL MLBr_02617|M.leprae_Br4923 -MRLSSYLRRFRWLVFTGWLLALVPAIYLAMTQSGKLTGGGFEVAGSQSL MAB_4529|M.abscessus_ATCC_1997 MMRTSDYLRRYRWLTVAVWLILIVAAVGLVAGRGEKLTGGGFEVAGSQSL :* * **: ** ..: *:: ::.:: *. :******:* ***** Mflv_0464|M.gilvum_PYR-GCK YVQRQLEAQFPDQGASPLALVAAPRPDASFEDMNNAVAQLESLAAEIP-S Mvan_0188|M.vanbaalenii_PYR-1 YVQRQLEAQFPDQGASPLALVAAPRSDASYDDMTSAVSHLERLAAEVP-S MSMEG_0241|M.smegmatis_MC2_155 HVQRQLEEHFPDQGASPLALVAAPRADASYEDMNAAVVHLEKLAAEVP-S TH_3087|M.thermoresistible__bu RVQHELEDHFPDEGASPLALVAAPRADATFEDMNAAVAFLEQVAAEVSDD Rv0202c|M.tuberculosis_H37Rv LVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELP-G Mb0208c|M.bovis_AF2122/97 LVHDQLDAHYPDRGAPALALVAAPRPDASYQDIDNAVALLRQIASELP-G MMAR_0442|M.marinum_M QVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGEFP-G MUL_1092|M.ulcerans_Agy99 RVHDVLEAQYPDQGASSLALVATPRPDASYQDITDAVAQLRRIAGEFP-G MAV_4973|M.avium_104 AVHDQLEDLYHDQGGSSLALVAAPRADASYQDMNDAVAQLRRIAAEVP-G MLBr_02617|M.leprae_Br4923 LVHDQLQEQYPDQGAVSLALVAAPRSDASYQDMNDAVALLRRIVSEFP-G MAB_4529|M.abscessus_ATCC_1997 KVHDAMETGFREQGASPLALVAAPRPDATVSDMAAAVDYLKQVAAQIP-Q *: :: : :.*. .*****:**.**: .*: ** *. :..:.. Mflv_0464|M.gilvum_PYR-GCK ITVVPSPQQPPPQPDRPYVVTLAMDFENTGAVDIAKQLREKVGVDGEDAG Mvan_0188|M.vanbaalenii_PYR-1 VTVVPTPQQPPPRPDRPYVITLQLDFENTGAVDVAKQLREKVGVDGEEPG MSMEG_0241|M.smegmatis_MC2_155 VKIVPNPQQPAPQPDRPYVITLQLDFNNTGAVDVAKQLRQKVGIHGEEPG TH_3087|M.thermoresistible__bu VRIKPNPQQPPPRPDRPYVLTLQLDFDNTGAVDVSNQLREKVGIDGDRPG Rv0202c|M.tuberculosis_H37Rv VTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSG Mb0208c|M.bovis_AF2122/97 VTEAPNPTQRPPQPDRPYVVSLRLDARNAGTSDVAKKLRDRIGVKGDQSG MMAR_0442|M.marinum_M VSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVGVEGDKPG MUL_1092|M.ulcerans_Agy99 VSEVPDPTQRPPQPDRPYVVSLRLDARNAGTSDLAKKLRARVGVEGDKPG MAV_4973|M.avium_104 TTEIPNPTQRPPQPDRPYVLSVRLDSRN--TSDVAKQLRTKVGIKGDQPG MLBr_02617|M.leprae_Br4923 VSEVPNPTQLPPRPDRPYGVSLRLDDRNSVTSDVAKQLRTKVGIKGDQAG MAB_4529|M.abscessus_ATCC_1997 VSVEPIPPQLTPQPDRPFVVTLRIGFDNTGATDIAKSLRKKIGVHGGQPG * * * .*:****: ::: :. * : *:::.** ::*:.* .* Mflv_0464|M.gilvum_PYR-GCK ETENGKVRLYVIGQGALGAAATEATKDDIAQAEKWNFPIVLVILLAVFGS Mvan_0188|M.vanbaalenii_PYR-1 EMENGKVRLYVIGQGALGAAATLATKHDIAQAEKWNFPIVLVILLAVFGS MSMEG_0241|M.smegmatis_MC2_155 ESQNGKVKFYVIGQGALGAAATQATKHDIAAAEKWNMPIVLIVLLAVFGS TH_3087|M.thermoresistible__bu ETDNGRVRLYVVGQGALGAAASEATKHDIAQAERWNLPIVLIILLAVFGS Rv0202c|M.tuberculosis_H37Rv QTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGS Mb0208c|M.bovis_AF2122/97 QTANGKVRLYVIGQGALSAAAAANTKHDIANAERWNLPIILMVLVAVFGS MMAR_0442|M.marinum_M QTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIVLLAVFGS MUL_1092|M.ulcerans_Agy99 QTADGRVRLYVIGQGALSAAAAANTKHDIAAAERWNLPIILIVLLAVFGS MAV_4973|M.avium_104 QTANGRVRLYVIGQGALSAAAAANTKHDIAAAEKWNLPVILIVLLAVFGS MLBr_02617|M.leprae_Br4923 RTANGKVRLYVIGQGALSAAVAANSKHDIAEAERWNLPIILIVLLAVFGS MAB_4529|M.abscessus_ATCC_1997 QIAGGRVSLYVIGQGALGAAMTEQIAGDIKKAEKWNIPVILIVLIAAFGS . .*:* :**:*****.** : ** **:**:*::*::*:*.*** Mflv_0464|M.gilvum_PYR-GCK LAAAAMPLLLGVCTVVVTMGVVFVLSMYTTMSVFVTSTVSMFGIAVAIDY Mvan_0188|M.vanbaalenii_PYR-1 LAAAAMPLLLGVCTVVVTMGLVFLLSMYTTMSVFVTSTVSMFGIAVAIDY MSMEG_0241|M.smegmatis_MC2_155 LAAAALPLVLGVCTVVVTMGLVYLLSMFTTMSVFVTSTVSMFGIAVAIDY TH_3087|M.thermoresistible__bu LAAAAVPLVLGVCTVVVTMGVVYLLSLVTTMSVFVASTVSMLGIALAIDY Rv0202c|M.tuberculosis_H37Rv LAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDY Mb0208c|M.bovis_AF2122/97 LAAAAIPLALAVCTVVITMGLVFVLSMHTTMSVFVTSTVSMFGIALAVDY MMAR_0442|M.marinum_M LTAAAIPLALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFGIALAVDY MUL_1092|M.ulcerans_Agy99 LTAAAIALALGICTVVVTMGLVYLLSMHTTMSVFVTSTVSMFGIALAVDY MAV_4973|M.avium_104 LAAAAIPLALGICTVVVTMGLVYLLSAYTTMSVFVTSTVSMFGIALAVDY MLBr_02617|M.leprae_Br4923 LAAAAVPLALGVCTVVVTMGLVDLVSMHTIMSVFVTSTVSMFGIALAVDY MAB_4529|M.abscessus_ATCC_1997 LAAASLPLLLGVCTVALSVAIVLALSNITTISVFALPTVTMIGLAVAVDY *:**::.* *.:***.:::.:* :* * :***. .**:*:*:*:*:** Mflv_0464|M.gilvum_PYR-GCK SLFILMRFREELRAGREPEDAADAAMATSGLAVVLSGLTVIASVTGIYLI Mvan_0188|M.vanbaalenii_PYR-1 SLFILMRFREELRAGREPEDAADAAMATSGLAVLLSGLTVIASVTGIYLI MSMEG_0241|M.smegmatis_MC2_155 SLFILMRFREELRAGRDQQDAIDAAMATSGLAVALSGLTVIASVTGIYLI TH_3087|M.thermoresistible__bu SLFILMRFREELRAGRDVDQAADAAMATSGLAVVLSGLTVIASVTGLYLI Rv0202c|M.tuberculosis_H37Rv SLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLI Mb0208c|M.bovis_AF2122/97 SLFILMRYREELRCGRRPPDAVDAAMATSGLAVVLSGMTVIASLTGIYLI MMAR_0442|M.marinum_M SLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVVASLSGIYLI MUL_1092|M.ulcerans_Agy99 SLFILMRFREELRSGRQPQEAADAAMATSGLAVVLSGMTVVASLSGIYLI MAV_4973|M.avium_104 SLFILMRFREELRSGRQPREAVDAAMATSGLAVVLSGMTVIASLTGIYVI MLBr_02617|M.leprae_Br4923 SLFILMRFREELRSGRQPQEAVDAAMATSGLAVVLSGMTVIASLTGIYLI MAB_4529|M.abscessus_ATCC_1997 SLFILMRYREELNSGKNRQEAIAGAMATSGLTVTFSGLTVIAALAGIYLI *******:****..*: :* .*******:* :**:**:*:::*:*:* Mflv_0464|M.gilvum_PYR-GCK NTPVLQSMATGAILAVAIAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRG Mvan_0188|M.vanbaalenii_PYR-1 NTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRG MSMEG_0241|M.smegmatis_MC2_155 NTPVLVSMATGAILAVAVAVLTSTTLTPAVLATFGKAAAKRSSYLHWSRR TH_3087|M.thermoresistible__bu NTPVLRSMATGAVLAVAVAVLAATTLTPAVLATFGRAAARRSSYLHWSRR Rv0202c|M.tuberculosis_H37Rv NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRR Mb0208c|M.bovis_AF2122/97 NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALVHWSRR MMAR_0442|M.marinum_M NTPALRSMATGAILAVAVAMLTSATLTPAVLATFARAAAKRSALLHWSRR MUL_1092|M.ulcerans_Agy99 NTPALRSMATGAILAVAVAILTSATLTPAVLATFARAAAKRSALLHWSRR MAV_4973|M.avium_104 NTPALKSMATGAILAVAVAMLTSTTLTPAALATFGRAAAKRSALLHWSRR MLBr_02617|M.leprae_Br4923 NTAALKSMATGAILAVAIAMLASITLTPAALATFGRAAVKRSVLMHWSQR MAB_4529|M.abscessus_ATCC_1997 GTPALASMASGAIIVVAIAVLTSTTLMPALLAIFGKAAANQSRFLRVSP- .*..* ***:**::.**:*:*:: ** ** ** *.: *..:* :: . Mflv_0464|M.gilvum_PYR-GCK VEATQSKFWTRWTGWVMRRPWLSAMAAAAVLLTFAAPAFSMMLGNSMQRQ Mvan_0188|M.vanbaalenii_PYR-1 VEATQSKFWSRWTGWVMRRPWVSATAAAAVLLAFAAPAFSMMLGNSMQRQ MSMEG_0241|M.smegmatis_MC2_155 AEAAQSRFWTRWTGAVMRRPWASAIAAAILLLVLAAPAFNMVLGNSMQRQ TH_3087|M.thermoresistible__bu PETTQSPFWTRWTGQVMRRPWVSAAAASAVLLVMAAPTVAMELGNSMQRQ Rv0202c|M.tuberculosis_H37Rv PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ Mb0208c|M.bovis_AF2122/97 PASTQSWFWSRWVGWVMRRPWITALAASTVLLVMAAPATLMVLGNSLLRQ MMAR_0442|M.marinum_M PESTQSRFWTRWVGWVMHRPWITALSASVVLLLMAAPAASMVLGNSLLRQ MUL_1092|M.ulcerans_Agy99 PESTQSRFWTRWVGWVMHRPWITALSASVVLLLMAAPAASMVLGNSLLRQ MAV_4973|M.avium_104 PESTQSKFWNRWIGWVMRRPWMSALAASLVLLVMAAPAASMVLGNSLLRQ MLBr_02617|M.leprae_Br4923 SECTQSLFWTRWVGWVMHRPWISASAASTILIIMATPVTSMMLGNSLLRQ MAB_4529|M.abscessus_ATCC_1997 LRKHSIPFWRKWTQQVMRRPWLSALGASIFLLALAAPSLQMHVSNSMLRQ . ** :* **:*** :* .*: .*: :*:* * :.**: ** Mflv_0464|M.gilvum_PYR-GCK FDTTHEIRGGVSAAAEALGPGALGPIRVLITFPDGD--AASASAKEPLLA Mvan_0188|M.vanbaalenii_PYR-1 FDPTHEIRGGVNAAAEALGPGALGPIRVLVTFPVDD--GAEAAA--PLLE MSMEG_0241|M.smegmatis_MC2_155 FDPTHEIRGGVNAAADALGPGALGPIRVLVTFPGEG--DASSQAATTTIE TH_3087|M.thermoresistible__bu FEPTHEIRGGVNAAAEALGPGALGPVRVMVSFP-DG--AASQPANAGTLD Rv0202c|M.tuberculosis_H37Rv FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---GASAPEHSQTIA Mb0208c|M.bovis_AF2122/97 FDSSHEIRTGAAAAAQALGPGALGPVQVLVRFDAG---GASAPEHSQTIA MMAR_0442|M.marinum_M FDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG---GASTPAHSQTVG MUL_1092|M.ulcerans_Agy99 FDSSHEIRAGVSAAAQALGPGALGPVQVLIKFPDG---GASTPAHSQTVG MAV_4973|M.avium_104 FDSSHEIRAGVGAAAQALGPGALGPIRVLINFPDG---GAASPEHSHTVG MLBr_02617|M.leprae_Br4923 FNSSHEIRAGVAAAAQALGPGALGPVQVLITFPDDPNTQASSPKHRQTIG MAB_4529|M.abscessus_ATCC_1997 FDSSHEIRRGIDAAAVAMGPGALGPVQVLLTFKDSP-----AHAHAQALE *:.:**** * *** *:*******::*:: * : Mflv_0464|M.gilvum_PYR-GCK ELRQTMAGAPNVVSVTPPVFGTDYRIALLSAVLSVDPEDMGARETIDWMR Mvan_0188|M.vanbaalenii_PYR-1 SLRQKMGQAPNTVSVSPPVFGSDGRSALLSAVLSVDPEDMGARDTVDWMR MSMEG_0241|M.smegmatis_MC2_155 AVRQQMTKAPSVVSVQPPVVSDDNDSALLSAVLSVDPEDMAAREAIDWMR TH_3087|M.thermoresistible__bu AVRQEISRAPNVVSVSPPVFADDDSSALLSAVLSVDPEDMRARDTIDWLR Rv0202c|M.tuberculosis_H37Rv AIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMR Mb0208c|M.bovis_AF2122/97 AIRHRIAQAPNVVSVAPPRFADDNGSALLSAVLSVDPEDLGARDTITWMR MMAR_0442|M.marinum_M AVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSVDPEDMGARHTVDWMR MUL_1092|M.ulcerans_Agy99 AVRQRMAQGPNVTTVAPPKFAEDNDSALLSAVLSVDPEDMGARHTVDWMR MAV_4973|M.avium_104 AVRQRMAQAPNIVSVSPPQFAEDNGSALLSAVLSVDPEDMKARETVGWMR MLBr_02617|M.leprae_Br4923 AIRNRMLQAKNVMSVAPPQFADNNCSALLGAVLSVDPEDLGARETVDWMR MAB_4529|M.abscessus_ATCC_1997 TAKETIAQAPNIARVSDVSFSTDGHDALISAVLSVDPEANAARDTVSWLR :. : . . * .. : **:.******** **.:: *:* Mflv_0464|M.gilvum_PYR-GCK EKLPPVA-GDAASIDVGGPTALIKDFDDKVSATQPLVFAFVALIAFVMLL Mvan_0188|M.vanbaalenii_PYR-1 EQLPPVA-GDAARVDVGGPTALIKDFDDRVSQTQPLVFVFVALIAFVMLL MSMEG_0241|M.smegmatis_MC2_155 AELPGVA-GQNATIDVGGPTALIKDFDDRVSATQPLVFVFVALIAFVMLL TH_3087|M.thermoresistible__bu EHLPAAA-GDGARTDVGGPTALIKDFDDEVATTQPLVFVFVAVIAFVMLL Rv0202c|M.tuberculosis_H37Rv TQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLL Mb0208c|M.bovis_AF2122/97 TQLPRV--AGAAQVDVGGPTALIKDFDDRVSATQPLVLVFVAVIAFLMLL MMAR_0442|M.marinum_M SELPQV--AGGAQVDVGGSTALIKDFDDRVSATEPLVLAFVALIAFVMLL MUL_1092|M.ulcerans_Agy99 SELPQV--AGGAQFDVGGSTALIKDFDDRVSATEPLVLAFVALIAFVMLL MAV_4973|M.avium_104 AELPKVSEAGTARVDVGGPTALIKDFDDRVSATEPLVLGFVALIAFVMLL MLBr_02617|M.leprae_Br4923 TELPKV--PGAAHVNVGGPTALINDFDDRVAKTEPLMLVFVALIAFVMLL MAB_4529|M.abscessus_ATCC_1997 ANVPDALENSGADINVGGPTALLFDYDTRVEHSLLGVFAFVCVLAFVMLL .:* . * :***.***: *:* .* : :: **.::**:*** Mflv_0464|M.gilvum_PYR-GCK VSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGWLSSLGFDQLSSLDST Mvan_0188|M.vanbaalenii_PYR-1 VSIRSVFLAFKGVLMTVLSVAAAYGSLVVVFQWGWLADLGFKQISSLDST MSMEG_0241|M.smegmatis_MC2_155 VSIRSVVLAFKGVLMTVLSVAAAYGSLVVVFQWGWLEQLGFPRISSLDST TH_3087|M.thermoresistible__bu IAIRSPVLALKGVLMTVLSVAAAYGSLVAVFQWGWLAPLGFEPISSLDST Rv0202c|M.tuberculosis_H37Rv ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDST Mb0208c|M.bovis_AF2122/97 ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWARGLGFPALHSIDST MMAR_0442|M.marinum_M ISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGWGERLGFPQLTSIDST MUL_1092|M.ulcerans_Agy99 ISIHSVLLALKGVLMTLLSVAAAYGSLVMVFQWGWGERLGFPQLTSIDST MAV_4973|M.avium_104 VSIHSVFLALKGVLMTLLSVAAAYGSLVMVFQWGWLRDLGFAQISSIDST MLBr_02617|M.leprae_Br4923 ISIRSVFLAFKGVLMTLLSVAAAYGSLVMVFQWGWLENLGFTHINSIDST MAB_4529|M.abscessus_ATCC_1997 ATLRSPVLALKGVVMTVLSVAAAYGSLVIVFQWGWLEFLGFHKAN-IDSS :::* .**:***:**:*********** ****** *** :**: Mflv_0464|M.gilvum_PYR-GCK IPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTIT Mvan_0188|M.vanbaalenii_PYR-1 IPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTIT MSMEG_0241|M.smegmatis_MC2_155 IPPLVLAMTFGLSMDYEIFLLTRIRERFLQTNSTRDAVAYGVSTSARTIT TH_3087|M.thermoresistible__bu IPPLVLALTFGLSMDYEIFLLTRIRERFLQTQDTRDAVAYGVSTSARTIT Rv0202c|M.tuberculosis_H37Rv VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT Mb0208c|M.bovis_AF2122/97 VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGQTRDAVAYGVRTSARTIT MMAR_0442|M.marinum_M VPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGRTRDAVAYGVSTSARTIT MUL_1092|M.ulcerans_Agy99 VPPLVLAMTFGLSMDYEIFLLTRIRERFLHTGRTRDAVAYGVSTSARTIT MAV_4973|M.avium_104 VPPLVLAMTFGLSMDYEIFLLTRIRERFLHSGNTRDAVAYGVSTSARTIT MLBr_02617|M.leprae_Br4923 VPPLVLAMTFGLSMDYEIFLLTRIRERFLQTGHTRDAVAYGVSTSARTIT MAB_4529|M.abscessus_ATCC_1997 IPPLALALTFGLTMDYEIFLLARVRERYLRTGDCGDAVSYGVRTSARTIT :***.**:****:********:*:***:*:: ***:*** ******* Mflv_0464|M.gilvum_PYR-GCK SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAM Mvan_0188|M.vanbaalenii_PYR-1 SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATIVRLVLVPALMAM MSMEG_0241|M.smegmatis_MC2_155 SAALIMIAVFIGFAFAGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM TH_3087|M.thermoresistible__bu SAALIMIAVFTGFAFAGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM Rv0202c|M.tuberculosis_H37Rv SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM Mb0208c|M.bovis_AF2122/97 SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATVVRLVLVPALMAM MMAR_0442|M.marinum_M SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATIVRLIMVPALMAM MUL_1092|M.ulcerans_Agy99 SAALIMIAVFCGFAFAGMPLVAEIGVACAVAIAVDATIVRLIMVPALMAM MAV_4973|M.avium_104 SAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDATVVRLVMVPALMAM MLBr_02617|M.leprae_Br4923 SAALIMIAVFVGFAFAGMPLVAEIGVACAVAIAVDVTAVRLVLVPTLMAM MAB_4529|M.abscessus_ATCC_1997 SAALIMIAVFIGFAFVGMPLVAQLGVACAVAIAVDATVVRLVLVPALMAM ********** ****.******::***********.* ***::**:**** Mflv_0464|M.gilvum_PYR-GCK FDEWNWWLPRWLDRLLPSVDFEKPLPKADIG--DLVIIPDDISALAPSGS Mvan_0188|M.vanbaalenii_PYR-1 FDEWNWWLPRWLDRILPSVDFEKPLPKADIG--DLVIIPDDISALAPSGS MSMEG_0241|M.smegmatis_MC2_155 FDQWNWWLPRWLDKILPEVDFEKPLPKIEVT--DLVIIPDNIAALGPSGS TH_3087|M.thermoresistible__bu FDKWNWWLPPWLDRLLPSVDFEKPLPHTDIG--DLVIIPDDISALMPPGS Rv0202c|M.tuberculosis_H37Rv FDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--DVVVIPDDFAAAIPPSA Mb0208c|M.bovis_AF2122/97 FDRWNWWLPRWLAHILPSVDFDRPLPKVDLG--DVVVIPDDFAAAIPPSA MMAR_0442|M.marinum_M FSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--DVVVIPEDIAATIPPGA MUL_1092|M.ulcerans_Agy99 FSQWNWWLPRWLGRILPSVDFDRPLPEVDLA--DVVVIPEDIAATIPPGA MAV_4973|M.avium_104 FAQWNWWLPPWLSRVLPSVDFDRPLPEVDLG--DVVVIPDDISALTAPSA MLBr_02617|M.leprae_Br4923 FAQWNWWLPRWLSRALPAVDFDKPFPPVDLN--EIVVLPADISATKVPCG MAB_4529|M.abscessus_ATCC_1997 FDKRNWWLPGWLDHVLPTVDFETPCVDELPGPHSESALRLQGSGFEEPRI * . ***** ** : ** ***: * . : : :. . Mflv_0464|M.gilvum_PYR-GCK DLRTVVKSAAKLKTLVP-QAVTVADPLAFSGCLPCNKMTGTRV------- Mvan_0188|M.vanbaalenii_PYR-1 DLRTVVKSAAKLKTLAP-QAITVADPLAFSGCLPCGKISGNRV------- MSMEG_0241|M.smegmatis_MC2_155 DLRTMVRTAARMKTLAP-QTISVADPLAFSGCT----------------- TH_3087|M.thermoresistible__bu QLRSVVRSAAKLKSLAP-ETITVADPLAFSGCVRSGEPLGPRIK------ Rv0202c|M.tuberculosis_H37Rv DVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGCDGK------------- Mb0208c|M.bovis_AF2122/97 DVRMVLKSAAKLKRLAP-DAICVTDPLAFTGCGCDGK------------- MMAR_0442|M.marinum_M DLRMVLKSAAKLKQLAP-DTICVADPLAFTGCERVGKGPERIPELVKDG- MUL_1092|M.ulcerans_Agy99 DLRMVLKSAAKLKQLAP-DTICVADPLAFTGCEGVGKGPERIPELVKDG- MAV_4973|M.avium_104 DLRMVLKSAAKLKHLAP-DAICVTDPLAFTGCGRTTAAGADPARGLGPGQ MLBr_02617|M.leprae_Br4923 DLRMVLKLAAKLKNLAP-DAICVADPLAFTGCGRNNKRSDRVLPGAATQE MAB_4529|M.abscessus_ATCC_1997 DYHAIAVSAARLKRLADGGTITAPDTQAVLADR----------------- : : : **::* *. :: ..*. *. . Mflv_0464|M.gilvum_PYR-GCK --------------------------GRDERITAAVSN----RAHGKTVA Mvan_0188|M.vanbaalenii_PYR-1 --------------------------GRDERITAAVTN----RAHGKTVA MSMEG_0241|M.smegmatis_MC2_155 ------------------------------RPTTRLST----QRAGRPKA TH_3087|M.thermoresistible__bu --------------------------GGDDGTTVPVRTGGGGRRAGTAVA Rv0202c|M.tuberculosis_H37Rv ---------------------------------ALDQVQ-LAYRNGIARA Mb0208c|M.bovis_AF2122/97 ---------------------------------ALDQVQ-LAYRNGIARA MMAR_0442|M.marinum_M ------LNLAGGTDTAGPGGAAEAKNGSNGQSAARKAVG-LAYRSGIARA MUL_1092|M.ulcerans_Agy99 ------LNLAGGTDTAGPGGGAEAKNGSKGQSAARKAVG-LAYRSGIARA MAV_4973|M.avium_104 IPHQVALREEKVGVAAGPGEKTGSNGHTNGSAGAKKPAA-RNGRNGIAKA MLBr_02617|M.leprae_Br4923 SEEDPAMGKASDSTAALTAAQVGPVTRTNGHWTARNLVIGLTHRNSITRV MAB_4529|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_0464|M.gilvum_PYR-GCK VKLP---KHPVTMWRGRLDVALEALATER------AQNEGHPTIERISPL Mvan_0188|M.vanbaalenii_PYR-1 VKLP---KHPVTMWRGRLDVALDALAVEQ------SAGNGEPRIERISPM MSMEG_0241|M.smegmatis_MC2_155 HTPG---LHPVTMWRGRLSVAVDALQTEA------DTEQAP--VERRGPV TH_3087|M.thermoresistible__bu TRPA---VHPVTLWLDRLEVALDALHTAA------DLDGAP--VERRSPM Rv0202c|M.tuberculosis_H37Rv ISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPV Mb0208c|M.bovis_AF2122/97 ISWGQRPVHPVTVWRKRLAVALDALQTTTWECGGVQTHRAGPGYRRRSPV MMAR_0442|M.marinum_M MSWAERPVHPVTVWRGRLSIALDALETNASERRAGPGGGREPSYRRRSPV MUL_1092|M.ulcerans_Agy99 MSWAERPVHPVTVWRGRLSIALDALETNASERRAGPGSGREPNYRRRSPV MAV_4973|M.avium_104 IAGADRPVHPVTLWRGRLSVALDALQTDP------DSGADRPRFRRRSPV MLBr_02617|M.leprae_Br4923 MPWSDRPVHPFTLWRSRFSVAIDALEAHIAVQ---ADAPDQPNYQRCSPV MAB_4529|M.abscessus_ATCC_1997 -------------WRDNLTVALEALQTSK-NGTDTDIVEMPGPLSRVTPV * .: :*::** . * *: Mflv_0464|M.gilvum_PYR-GCK ETTNVLLPTGDRLQIPTGAETLRLKSYLILERNSTRDFSEFSELVDSMDT Mvan_0188|M.vanbaalenii_PYR-1 ETTNVLLPTGDRLQIPTGAETLRLKGFLIMSRNTARDYRDFTELVDSMDV MSMEG_0241|M.smegmatis_MC2_155 ETTNVQLPTGDRLQIPTGAETLRLAGYLIMCRNTTKDFEDFARLVDLMDS TH_3087|M.thermoresistible__bu ETTTVQLPTGDRLQIPTGAETVRLMGYLIMCRNSARDYAEFADLVECMDA Rv0202c|M.tuberculosis_H37Rv ETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAP Mb0208c|M.bovis_AF2122/97 ETTNVALPTGDRLQIPTGAETLRFKGYLIMSRNSSHDYADFADLVDTMAP MMAR_0442|M.marinum_M ETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNSSRDYAELADMVEAMEP MUL_1092|M.ulcerans_Agy99 ETTNVQLPTGDRLLIPTGAETLRLKGYLIMSRNSSRDYAELADMVEAMEP MAV_4973|M.avium_104 ETTNVQLPTGDRLLVPTGAEALRLKGYLLMCRNSRRDYADFADMVDALEP MLBr_02617|M.leprae_Br4923 ETAHVQLPTGDRLLIPTGAETLRLVSYLIMCRNSIRDYAELADMVDAIEP MAB_4529|M.abscessus_ATCC_1997 EITQVKLPTGQKCVVPTDAEALRMQGLLLMRRNAERDYTEFARLASAMEP * : * ****:: :**.**::*: . *:: **: :*: ::: :.. : Mflv_0464|M.gilvum_PYR-GCK STAAEVLASMDRYYSGQSARDQQAGARTRHWVATQLVRRLAEPAPADGPD Mvan_0188|M.vanbaalenii_PYR-1 DTAADVLAGMDRYYAGQPAR--------AHWVATQLVRRLAEPLPSDGPD MSMEG_0241|M.smegmatis_MC2_155 HTAALVLASMDRYYCGRDPS--------NRWVATQLVRRLADPQPSDEHD TH_3087|M.thermoresistible__bu ETAAAVLARMDRYYCGQYPR--------QHWVATQLVRRLADPHPSDVDD Rv0202c|M.tuberculosis_H37Rv ETAAAVLAGMDRYYSCQAPG--------RQWMATQLVGRLADPQPSD-LG Mb0208c|M.bovis_AF2122/97 ETAAAVLAGMDRYYSCQAPG--------RQWMATQLVGRLADPQPSD-LG MMAR_0442|M.marinum_M ETAAVVLAGMDRYYCCQPPR--------RQWIATQLVRRLADPHPSD-VD MUL_1092|M.ulcerans_Agy99 ETAAVVLAGMDRYYCCQPPR--------RQWIATQLVRRLADPHPSD-VD MAV_4973|M.avium_104 ETAAVVLAGMDRYYCCESSR--------RQWIATQLVRRLADPDPCDYPD MLBr_02617|M.leprae_Br4923 ETAAVVLTELDRYYSCQLPM--------RQWMATQLVRRLSDPHPVDLTE MAB_4529|M.abscessus_ATCC_1997 RMAAKVLAGIDQHYCVQSNQ---------RWVSSQLVRRLADPKPGD--- ** **: :*::*. . :*:::*** **::* * * Mflv_0464|M.gilvum_PYR-GCK IAAAGADGEAEWATVRQRCLSVAVAMLEETR Mvan_0188|M.vanbaalenii_PYR-1 IAAAGADEETEWAKVRQRCLSVAVAMLEETR MSMEG_0241|M.smegmatis_MC2_155 VRMSGPDAAEDWEKVRQRCLSVAVAMLEEAK TH_3087|M.thermoresistible__bu DGETESSAVADWDEVRKRCLSVAVAMLEEAR Rv0202c|M.tuberculosis_H37Rv DQSPGADAQAKWEEVRRRCLSVAVAMLEEAR Mb0208c|M.bovis_AF2122/97 DQSPGADAQAKWEEVRRRCLSVAVAMLEEAR MMAR_0442|M.marinum_M VEWPQPDDKADWEEVRQRCLAVAVAMLEEAR MUL_1092|M.ulcerans_Agy99 VEWPQPDDKADWEEVRQRCLAVAVAMLEEAR MAV_4973|M.avium_104 DQGPDADAPADWEQIRQRCLAVAVAMLEEAR MLBr_02617|M.leprae_Br4923 DQWSDPDNKAEWQDVRQRCLSVAVAMLEEAR MAB_4529|M.abscessus_ATCC_1997 -------GAMECPTVRRQCLSVAVAMLEDAR . :*::**:*******:::