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M. thermoresistible (build 8) TH_2203 (mmpL8)

annotation: PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN MMPL8
coordinates: 4309766 - 4312768
length: 1001

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2203mmpL8-100% (1001)PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN MMPL8
M. thermoresistible (build 8)TH_3450-0.042.02% (978) PUTATIVE MMPL domain protein
M. thermoresistible (build 8)TH_3260-e-12930.43% (989) PUTATIVE MmpL4 protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3853cmmpL80.055.79% (1011) integral membrane transport protein
M. gilvum PYR-GCKMflv_0403-0.054.20% (987) transport protein
M. tuberculosis H37RvRv3823cmmpL80.055.69% (1011) integral membrane transport protein
M. leprae Br4923MLBr_01231mmpL100.054.03% (979) hypothetical protein MLBr_01231
M. abscessus ATCC 19977MAB_0855-0.055.59% (984) MmpL family protein
M. marinum MMMAR_2342-0.056.51% (1014) MmpL family transport protein
M. avium 104MAV_1761-0.054.80% (989) MmpL10 protein
M. smegmatis MC2 155MSMEG_4741-0.054.26% (986) MmpL protein
M. ulcerans Agy99MUL_0757mmpL51e-11528.46% (1005) transmembrane transport protein, MmpL5
M. vanbaalenii PYR-1Mvan_0271-0.053.56% (982) transport protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_2203|M.thermoresistible__bu      -------------------MGGTETPTGRGFFGRLGDFVIRFPLIVIGLW
MMAR_2342|M.marinum_M               -------------------MSDSEAARAGGFFDKLSRFVIQKPFVVIAIW
MAB_0855|M.abscessus_ATCC_1997      -----------------------MAENTGGIYGLIAQIVRRAPVIVIGLW
MSMEG_4741|M.smegmatis_MC2_155      -------------------------MSRVGFSGLGRFIVR-HPLVVIASW
Mb3853c|M.bovis_AF2122/97           MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFW
Rv3823c|M.tuberculosis_H37Rv        MCDVLMQPVRTPRPSTNLRSKPLRPTGDGGVFPRLGRLIVRRPWVVIAFW
MLBr_01231|M.leprae_Br4923          --------------------------------------------MVIGCW
Mflv_0403|M.gilvum_PYR-GCK          -------------------------------MRRLADVVVRWPWAVIGVW
Mvan_0271|M.vanbaalenii_PYR-1       -------------------------------MRRLADLVVRWPWAVIAVW
MAV_1761|M.avium_104                -------------------MSPTAPAGDEVEMRRIADFVVRWPWLVIGFW
MUL_0757|M.ulcerans_Agy99           -----------MTATTTDTPTDVVPPAEHPPRPFIPRMIRTFAVPLILGW
                                                                                 :*  *

TH_2203|M.thermoresistible__bu      VGLAVVLVATVPPLAEVAAR-NPVSVLPEDAPVMVTSREMSEAFD-----
MMAR_2342|M.marinum_M               ISLAAIPALMFPPLMEAAAGKNNSAALPDDAPTMVASKEMAKTFEGKSNK
MAB_0855|M.abscessus_ATCC_1997      IGLAAVLALTAPSLQKAIED-HPVDLLPKDAPVMETTRQMVESFQ-----
MSMEG_4741|M.smegmatis_MC2_155      LAVAGVLLAAVPSLPAVAER-NPPGFLPADSEVFAAGNAMQEAFN-----
Mb3853c|M.bovis_AF2122/97           VALAGLLAPTVPSLDAISQR-HPVAILPSDAPVLVSTRQMTAAFR-----
Rv3823c|M.tuberculosis_H37Rv        VALAGLLAPTVPSLDAISQR-HPVAILPSDAPVLVSTRQMTAAFR-----
MLBr_01231|M.leprae_Br4923          TLLALMLPMTVPSLTELTQR-HPVVILPVDAPSSVAAKKISQAFH-----
Mflv_0403|M.gilvum_PYR-GCK          IALAVALPLSFPSLGQMAAK-NPLQILPADAPSSVTAQKMAEAFD-----
Mvan_0271|M.vanbaalenii_PYR-1       VAMAVALPLSFPSLGEMAQK-HPLVILPSDAPSSVTAAKMAEAFQ-----
MAV_1761|M.avium_104                AALAVALPLAFPSLAEMAQK-HPLAILPGNAPSNVAARQMTEAFH-----
MUL_0757|M.ulcerans_Agy99           VLLIAVLNSVVPQLEVVGQM-QAVSMSPDAAPSMISMKHIGKVFR-----
                                      :        * *       :     *  :    :   :   *      

TH_2203|M.thermoresistible__bu      -------------DSGGDNLLLVVMTDEEGLGPEDEKAYQKLVAALRAEP
MMAR_2342|M.marinum_M               KDAKAKPGSKPKEDPSDGSQLLVILTDENGLGPGDLAAYTKLVEKLRAEK
MAB_0855|M.abscessus_ATCC_1997      -------------ESGAQNILLIVLTNENGLTPADEQTYRILAARMREDT
MSMEG_4741|M.smegmatis_MC2_155      -------------ETGGGNVAIAILSNENGLTPADEETYRALVDKLRADT
Mb3853c|M.bovis_AF2122/97           -------------EAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDT
Rv3823c|M.tuberculosis_H37Rv        -------------EAGLQSVAVVVLSDAKGLGAADERSYKELVDALRRDT
MLBr_01231|M.leprae_Br4923          -------------EVDSENVLIVLLTDDKGLGPADETVYRTLVDRLRNDT
Mflv_0403|M.gilvum_PYR-GCK          -------------EPGSDNLLVVAFINESGLVPEDELTYRNVVDALRDDV
Mvan_0271|M.vanbaalenii_PYR-1       -------------ETSNDNLLLVAFINETGLEPADEATYRKVVDALRDDV
MAV_1761|M.avium_104                -------------ESGSDDLLLVALTDEKGLGPADEAVYRRLVDALRRDT
MUL_0757|M.ulcerans_Agy99           -------------EGDSDSAAMIVLEGQEPLGAAAHKFYDKMITKLRADT
                                                 : .  .  :  : .   * .     *  :   :* : 

TH_2203|M.thermoresistible__bu      NGDIMMMQDFITTPQLREVVASEDGKAWYLPINLAGAWSTPEGGGAFTRV
MMAR_2342|M.marinum_M               YS----VQDFISNPPLREVLASKDNKAWNLPVMFKTSQDDPATQSAYKKI
MAB_0855|M.abscessus_ATCC_1997      RD-VSMVQDFITKPPLREMMSSTDGKAWYLPVGLQGELATPESGKAYVGA
MSMEG_4741|M.smegmatis_MC2_155      EY-VLSTQDFVTIPELRQVMTSEDNKAWQLPISAAGTMGTAEGQNAYRQI
Mb3853c|M.bovis_AF2122/97           RD-VVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARV
Rv3823c|M.tuberculosis_H37Rv        RD-VVMLQDFVTTPPLRELMTSKDNQAWILPVGLPGDLGSTQSKQAYARV
MLBr_01231|M.leprae_Br4923          KD-VVVLQDFLSTPPLHELLVSKDGKAWILPIVLAGELGTSASYQAYAGV
Mflv_0403|M.gilvum_PYR-GCK          AD-VVSVQDFLGTPQLRQFLTSEDKTTWVLPVSLVGELGTPRAYESFNRV
Mvan_0271|M.vanbaalenii_PYR-1       TD-VVSVQDFVSTPQLRQFLTSEDKTTWVLPVSLEGELGTPRAFDSFNRV
MAV_1761|M.avium_104                RD-VVMVQDFISAPPLRSAVTSKDRKAWVLPVGIAGELGTPQSYAAFNRI
MUL_0757|M.ulcerans_Agy99           KH-VQSVQDFWGDPLTATGAQSGDGKAAYVQVKLAGNQGESLANESVEAV
                                           ***   *       * *  :  : :        .    :    

TH_2203|M.thermoresistible__bu      AEIVREATADA-------PMTVHLTGPAATIADVTAVGQRDIHVIEIATV
MMAR_2342|M.marinum_M               KELVKEALAGS-------TLTAHYAGAVATVADLVTIGQEDTHIIEIGTA
MAB_0855|M.abscessus_ATCC_1997      LKIIKDATQGT-------SLKAFTTGPTATVGDLTVVGERDLHKVEITTA
MSMEG_4741|M.smegmatis_MC2_155      VDTVKSSTANT-------SLSAEVIGPAATFEDVVKIGERDQHVIEIATV
Mb3853c|M.bovis_AF2122/97           ADIVEH---QVAGS----TLTANLTGPAATVADLNLTGQRDRSRIEFAIT
Rv3823c|M.tuberculosis_H37Rv        ADIVEH---QVAGS----TLTANLTGPAATVADLNLTGQRDRSRIEFAIT
MLBr_01231|M.leprae_Br4923          AGIVKQTLESTAGS----SLKANLTGPASTVADLTDAGARDRTSIELVIA
Mflv_0403|M.gilvum_PYR-GCK          ADVIRHEVPDAGTG--GSSLTVHVTGPAATVADLTVAGEQDRLPIEIAIA
Mvan_0271|M.vanbaalenii_PYR-1       SDVVKHHLGDG-------PLQVYLTGPAATVADLTVAGEQDRLPIEIAIA
MAV_1761|M.avium_104                AGIVKQTLEKHENGPAATSLTVSLTGPAATVADLTVAGERDRLPIELAIA
MUL_0757|M.ulcerans_Agy99           KTIVDSLQAPP-------GVKVYVTGSAALVADQQLAGDRSLQLIEMVTF
                                       :               : .   *..: . *    * ..   :*:   

TH_2203|M.thermoresistible__bu      VMVLTILLIVYRNVVTMLMPLVTIGVAFVTAQGLVGALAPLGLG-VSDQT
MMAR_2342|M.marinum_M               VSVLVILLMVYRNIVTMLVPLATIGLSLATAQGVLSGLSKIGLD-VQMQT
MAB_0855|M.abscessus_ATCC_1997      ALVLLILLIVYRNPVTMMLPLIVVGVSLGIAQAAVGGLAQMGLS-ISNQT
MSMEG_4741|M.smegmatis_MC2_155      LIVLMILIIVYRNLVAMLLPLLMIGMALVVAEQSVAGLGAIHLIGLGPQT
Mb3853c|M.bovis_AF2122/97           ILLLVILLIIYRNPITMVLPLITIGMSVVVAQRLVA-IAGLAGLGIANQS
Rv3823c|M.tuberculosis_H37Rv        ILLLVILLIIYGNPITMVLPLITIGMSVVVAQRLVA-IAGLAGLGIANQS
MLBr_01231|M.leprae_Br4923          VLLLTILMIIYRNPITMLLPLITIGASLMTAQAVVSGVSVLAGLAVSNQM
Mflv_0403|M.gilvum_PYR-GCK          VLVLGVLLLVYRNPVTMLLPLLTIGASVLIAQGVVAGYSELTGAGVSNQS
Mvan_0271|M.vanbaalenii_PYR-1       VLVLGVLLLVYRSAVTMLLPLVTIGSSLVIAQAVVAGYSQLSGSGVSNQS
MAV_1761|M.avium_104                VLVLVVLLVVYRSAVTMLLPLVTILLSLVIAQAAVAGYSQLTGSGVSNQS
MUL_0757|M.ulcerans_Agy99           TVIIVMLLLVYRSIITAAIMLTMVVLGLLATRGGVAFLGYHRIIGLSTFA
                                      :: :*:::* . ::  : *  :  ..  :.  :.  .      :    

TH_2203|M.thermoresistible__bu      IVLMTGIMVGAGVDYAVFLISRYHDFVRRGVEHRA----AIRQAMGSIGK
MMAR_2342|M.marinum_M               IVFMTAVMIGAGTDYAVFLISRYHDYVRKGQDSDL----AVKNAMMSIGK
MAB_0855|M.abscessus_ATCC_1997      LTFMTAMMMGAGVDYAVFLISRYHEYIKQGLASDD----AVAAALESIGK
MSMEG_4741|M.smegmatis_MC2_155      LMLMTAMMMGAGTDYAIFLFSRYHECVRSGLSSDD----AVVEALDSIGK
Mb3853c|M.bovis_AF2122/97           IIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQ----AVKKALTSIGK
Rv3823c|M.tuberculosis_H37Rv        IIFMSGMMVGAGTDYAVFLISRYHDYLRQGADSDQ----AVKKALTSIGK
MLBr_01231|M.leprae_Br4923          IVLLSAMIAGAGTDYAVFLISRYHDYIRMGSGSAQDAGCAVRQALISLGK
Mflv_0403|M.gilvum_PYR-GCK          IVFLSAILAGAGTDYAVFLISRYHDYLRRGAEAGE----AVRAAMASIGK
Mvan_0271|M.vanbaalenii_PYR-1       IVFLSAIMAGAGTDYAVFLISRYHDYLRSGADFDD----AVRAAMISIGK
MAV_1761|M.avium_104                IVFLSAIMAGAGTDYAVFLISRYHDFLRRGDDFDQ----AVRKALISIGK
MUL_0757|M.ulcerans_Agy99           TNLLVVLAIAAATDYAIFLIGRYQEARGLGQDRES----AYYTMFGGTAH
                                      ::  :  .*..***:**:.**::    *         *    : . .:

TH_2203|M.thermoresistible__bu      VIGASAATVAVTFFAMVFTTLSVFQTVGPAMALAIFVCFLAAVTFLPAMI
MMAR_2342|M.marinum_M               VIAASAATVAVTFLAMVFSKLAIFASIGPAISISIIIAFVAAITLLPSIL
MAB_0855|M.abscessus_ATCC_1997      VVAASAATVAVTFLGMGFTKLGILSTVGPALSVSILIAFVASVTFLPAVL
MSMEG_4741|M.smegmatis_MC2_155      VIAGSAGTVAITFMGLAFTDLGVFSTVGPALSVTIGFGFVASVTLLPAMV
Mb3853c|M.bovis_AF2122/97           VIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALM
Rv3823c|M.tuberculosis_H37Rv        VIAASAATVAITFLGMVFTQLGILKTVGPMLGISVAVVFFAAVTLLPALM
MLBr_01231|M.leprae_Br4923          VIAASAATVGITFLGMSFTKIRVFSTVGPALAIGIAVAFLAAVTLMPALL
Mflv_0403|M.gilvum_PYR-GCK          VITASASTVGITFLAMSFAEMGVFRTIGVSAAIGIGVAYLAGVTLLPAIL
Mvan_0271|M.vanbaalenii_PYR-1       VITASAATVGVTFLVMSFAQMGVFRTIGVSSAIGIGVAFLAGMTLLPAIL
MAV_1761|M.avium_104                VITASASTVGITFLLIGFARMGVFKTVGISSAIGIGVAFLAAVTLLPAIM
MUL_0757|M.ulcerans_Agy99           VVLGSGLTIAGATFCLSFTRLPYFQTLGVPLAIGMVIVVATALTLGPALI
                                    *: .*. *:. : : : *: :  : ::*   .: : .   :.:*: *:::

TH_2203|M.thermoresistible__bu      VLAGPRG-WISPRRDLTTRFWRRSGIRIVRAPKAHLAVSLIILLGLAGCA
MMAR_2342|M.marinum_M               VLIGRRG-WIKPRRDLTHRFWRILGTRIVRRPRVHLIGSLIVLAILASST
MAB_0855|M.abscessus_ATCC_1997      VLVGRRG-WITPRKAYANKIWHRSGINIVKRPGAHLAVSLVVLVILATCG
MSMEG_4741|M.smegmatis_MC2_155      VLAGRRG-WVKPRKDLTGRIWRRSGVHIVRKPVIHLVASLTVLLALAGCA
Mb3853c|M.bovis_AF2122/97           VLTGRRG-WIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCA
Rv3823c|M.tuberculosis_H37Rv        VLTGRRG-WIAPRRDLTRRFWRSSGVHIVRRPKTHLLASALVLVILAGCA
MLBr_01231|M.leprae_Br4923          VLAGTRG-WVAPRRDRAGAFWRRTGVRIVRRPVAYLSASMVILIVLALCA
Mflv_0403|M.gilvum_PYR-GCK          VLAGPRG-WIKPRRELTAQFWRRSGIRIVRRPVPHLVASALVLALLAGFA
Mvan_0271|M.vanbaalenii_PYR-1       VLAGPRG-WVKPRRELTARFWRRSGIRIVRRPVPHLVASVLVLILLAGCA
MAV_1761|M.avium_104                VLAGPRG-WIRPRRELTTGLWRRSGIRIVRRPRAHLVASVLVLIILASCA
MUL_0757|M.ulcerans_Agy99           AVMSRFGKLLEPKRMARVRGWRKIGAAIVRWPGPILIGAVALALVGLLTL
                                    .: .  *  : *::      *:  *  **: *   *  :  :        

TH_2203|M.thermoresistible__bu      LTVQFNYDDRKTLPQSVESAAGYAAMERHYPVNSNLPQYLFINSPRDLRS
MMAR_2342|M.marinum_M               LLVRFNYDDLKALPEDVDSVAGYNAMDRHFPQNMMTPMMLFIKSPHDLRS
MAB_0855|M.abscessus_ATCC_1997      AMVKFGYDDRKNLPPWADSNQGYAAIEKHFPVNSTLPQYLYIKSPHDLRT
MSMEG_4741|M.smegmatis_MC2_155      MLVNFNYDDRKNLPDDAHSNMGYAALDKHFPVSSTVQQFILIQSPHDLRS
Mb3853c|M.bovis_AF2122/97           GLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRT
Rv3823c|M.tuberculosis_H37Rv        GLARYNYDDRKTLPASVESSIGYAALDKHFPSNLIIPEYLFIQSSTDLRT
MLBr_01231|M.leprae_Br4923          SLVRFNYDDRKQIPASDESSVGYAALESHFPVGQAIPEYLLIQSPHDLRT
Mflv_0403|M.gilvum_PYR-GCK          IVADFNYDDRKAVDAAAPSSVGYAALERHFPISQSIPQYILIQSPKDLRN
Mvan_0271|M.vanbaalenii_PYR-1       AFATFNYDDRKAVAASAPSSVGYAALERHFPISQSIPQYILVQSPRDLRS
MAV_1761|M.avium_104                GLVRYNYDDRKALRPSAPSSVGYAALERHFPVNQSIPEYILIRSPHDLRT
MUL_0757|M.ulcerans_Agy99           PGYKTNYNDRNYLPADLPANEGYSAAERHFSQARMNPEVLMVESDHDMRN
                                         .*:* : :     :  ** * : *:.        : :.*  *:*.

TH_2203|M.thermoresistible__bu      PEALADLEEMARRVSQLPEVDTVRGITRPTGEPLEQAALSYQAGEVGIRL
MMAR_2342|M.marinum_M               PTALADLELMVSRVSQLPNIIAIRGLTRPNGEPLEQTKVSYQAGEVGSKL
MAB_0855|M.abscessus_ATCC_1997      PRGLADLEQMAARVSQVPGVDKVRGITRPTGEPLEEAKLSYQAGEVGGKL
MSMEG_4741|M.smegmatis_MC2_155      PKALADMEQMAQRVSQLPDIEMVRGVTRPTGEMLQEARATWQAGEVGGKL
Mb3853c|M.bovis_AF2122/97           PKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKL
Rv3823c|M.tuberculosis_H37Rv        PKALADLEQMVQRVSQVPGVAMVRGITRPAGRSLEQARTSWQAGEVGSKL
MLBr_01231|M.leprae_Br4923          PRALADMAELAQRVSQIPGIALVRGVTRPTGKPLEETSATYQAGMVGKQL
Mflv_0403|M.gilvum_PYR-GCK          PQALADLEQMASRIAQLPDVSLVSGVTRPLGEVPAEFRATFQAGIVGDRL
Mvan_0271|M.vanbaalenii_PYR-1       PQALADLEQMASRIAQLPDISLVSGVTRPLGEVPREFRATFQAGLVGDRL
MAV_1761|M.avium_104                PQALADLEQLADRVSQLPNVSVVSGITRPTGNVPEQFRATYQAGAIGSML
MUL_0757|M.ulcerans_Agy99           SSDFLVINKIAKAIFGVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQ
                                    .  :  :  :.  :  :  :  : .:*** *.   .   .:  .  *   

TH_2203|M.thermoresistible__bu      DDASKQITDHTGDLDMLADGADQLADALGDVRGQVFQTVATTKALVDALS
MMAR_2342|M.marinum_M               DEASSAIEDHGGELDQLADGSNQLADALAGVRDEVTESVANAGALVDLLV
MAB_0855|M.abscessus_ATCC_1997      GDASNLIDARTRDLDKLAAGGHTLADKLGQVRDSVKNSLGTARALVEVLA
MSMEG_4741|M.smegmatis_MC2_155      NDASTLIDANDANLSTLSGGAHKLADVLGQISTQVTNALVTVRPLAGALA
Mb3853c|M.bovis_AF2122/97           DEGSKQIAAHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALA
Rv3823c|M.tuberculosis_H37Rv        DEGSKQIAVHTGDIDKLAGGANLMASKLGDVRAQVNRAISTVGGLIDALA
MLBr_01231|M.leprae_Br4923          GSASHLIGESTGDLNRLASGAGLLADKLGDVRIQVGQAVAGISGLLDNLA
Mflv_0403|M.gilvum_PYR-GCK          AAGSAQIGERSGDLTTLADGATTLADSLGDVRSQVNEIAPSLKGIIDTFS
Mvan_0271|M.vanbaalenii_PYR-1       AAGSAQIGARDDDLDELTTGADTLADTLVDVRAQVNKIAPSLQTLLDAVT
MAV_1761|M.avium_104                AGGSTMINDQTDDLNRLARGAGTLADNLGDVRGQVNQLAASVRELENAFS
MUL_0757|M.ulcerans_Agy99           KLTEKYNQDLTTSMLQQVNDIQTNIDQMERMHDLTQQMADVT--------
                                       .        .:     .     . :  :   . .             

TH_2203|M.thermoresistible__bu      TLQERFGGDRTLDDIDNAARLVSGMRELGDAIGVNVANVAGNLEWAVPVL
MMAR_2342|M.marinum_M               TMKKLIGGDKTLNALDQTAKLVGRMRALGDALTSNMVDVSNVVAWVGPIV
MAB_0855|M.abscessus_ATCC_1997      QLRGS-GRTGTLADLDSVDKLVTSMHSLGDAIEANAQGASEVYGWIEPVA
MSMEG_4741|M.smegmatis_MC2_155      DMETKYGGEKTLDQIDQSAELVANMRSLGRAMGVNLARITDVYDWSAPMV
Mb3853c|M.bovis_AF2122/97           YLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVL
Rv3823c|M.tuberculosis_H37Rv        YLQDLLGGNRVLGELEGAEKLIGSMRALGDTIDADASFVANNTEWASPVL
MLBr_01231|M.leprae_Br4923          FAQKMFGDSKTLGEIDTAGKLVSSMRALGNMFGINFSTTMNDINWVGAVV
Mflv_0403|M.gilvum_PYR-GCK          SVRTEYGGDKLVRDVATAAKLVDSVNKLGLSMGINFRAVRDMFAWIGPVL
Mvan_0271|M.vanbaalenii_PYR-1       RVRVEYGGDRLVRDVETAAKLVQSVNELGLSMGISFAAVRDMFGWIGPVL
MAV_1761|M.avium_104                STKNQYSGDALVNQVDIAARLVDHVNSLSNAMGWNFTAAKNMFAWIGPVL
MUL_0757|M.ulcerans_Agy99           ------------------HQMVIQMKGMVVDVEELRNHIADFDDFFRPIR
                                                       .::  :. :   .            :  .: 

TH_2203|M.thermoresistible__bu      TALDTSPVCAADPRCVSAREELRQLTVAGRQGVLDRIAALGRQLEETRGG
MMAR_2342|M.marinum_M               SALNASPQCNADPACAAARSQLQALVAAQTSGSLSSITALGRTLQQTQEF
MAB_0855|M.abscessus_ATCC_1997      RVLVGNPACDMDPGCRSSRDEMNKFLETKQDGTRDKIVELGRELKSVDND
MSMEG_4741|M.smegmatis_MC2_155      RALNVSPECNLDPACAASRSDLQRIVEAKDNGNLDKFAELGRQLESTEGD
Mb3853c|M.bovis_AF2122/97           GALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAV
Rv3823c|M.tuberculosis_H37Rv        GALDSSPMCTADPACASARTELQRLVTARDDGTLAKISELARQLQATRAV
MLBr_01231|M.leprae_Br4923          IALDSSVLCDTNPICADARAQFHKLLTASEDGTLDNIAHLWKQLGSTQSS
Mflv_0403|M.gilvum_PYR-GCK          TALQGNRVCDANPSCVDTRMQFEKLVSAREDGRVDEINQLAGQLQGVDDR
Mvan_0271|M.vanbaalenii_PYR-1       AALHGNAVCDANPSCVNTRMQFERLMDARADGRLERINTLAGELEGLDDT
MAV_1761|M.avium_104                AALQGNPVCDADSSCSATRATFEQLVGPRGQADLDAIDDLSHQLQAYPDK
MUL_0757|M.ulcerans_Agy99           SYFYWEKHCFDIPVCWSLRSVFDTLDGVD---------------LMTEDI
                                      :  .  *   . *   *  :  :                         

TH_2203|M.thermoresistible__bu      QTIDQTLATLTGTLTDATAALRAAGLDKPGSLQAKIATMQEGADALADAS
MMAR_2342|M.marinum_M               QTVAQTIAKLETNLNQAVKLLRSIDG-----MQNQLNQMQQGASALAQGS
MAB_0855|M.abscessus_ATCC_1997      KQISSTIARLRTALNSIDTNLRRLGLSDSYGIQKRFTEVLTGVNSLADGS
MSMEG_4741|M.smegmatis_MC2_155      ETLDEAVSGLQQSIKEATAAARELGLEDASSVKRQLDQLEQGVNLLADSS
Mb3853c|M.bovis_AF2122/97           QTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGS
Rv3823c|M.tuberculosis_H37Rv        QTLAATVSGLRGALATVIRAMGSLGMSSPGGVRSKINLVNKGVNDLADGS
MLBr_01231|M.leprae_Br4923          QTIGATVSGLEKTLTAVNTSLRSLGLDNPNVMRSKMIGLQNGVNDLASAG
Mflv_0403|M.gilvum_PYR-GCK          QSLTATVNQLNGALAQVTKAISAMGLDTPAGARAGLDDLQDGADRLADGS
Mvan_0271|M.vanbaalenii_PYR-1       QSLNSTVKTLNAAMTNIVKAVDELGLDSPGGAQTSLRDIRQGTDRLASGS
MAV_1761|M.avium_104                RALKASTDRLRNAFAKLNDVLRAMGMDRPGGLQSNLTTLQNGADQFAGGS
MUL_0757|M.ulcerans_Agy99           NNLLPLMERLDTLMPQMTAMMP--------EMIQTMKSMKAQMLSMHSTQ
                                    . :      *   :                     :  :      :    

TH_2203|M.thermoresistible__bu      RKLADGVQLLVNQTKEMGSGLGEASSFLLAMKRDATTPAMAGFYIPPEVL
MMAR_2342|M.marinum_M               RAIAQGVNELVKQTKRMGTGLDEASDFLLQMKHDANKPSMAGFNIPPEAL
MAB_0855|M.abscessus_ATCC_1997      AQLAEGVQMLVDQTKQMGGQLGDASTLLVAAKRDAAPGSMSGFYIPQQVL
MSMEG_4741|M.smegmatis_MC2_155      HQLAQGVQLLVDQTRNMGQGLDQASQFLLAMKRDASDPQMSGFYIPPQIL
Mb3853c|M.bovis_AF2122/97           RQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELL
Rv3823c|M.tuberculosis_H37Rv        RQLAEGVQLLVDQVKKMGFGLGEASAFLLAMKDTATTPAMAGFYIPPELL
MLBr_01231|M.leprae_Br4923          RRIADGVAVLVDQTRTMGTSLARASAFLMEMGQDASQPSMAGFNVPPQLL
Mflv_0403|M.gilvum_PYR-GCK          RQVAGGVDQLVEQIKVMAAGLDQAAAFLLTMRNDASSSNMAGFSIPAEVL
Mvan_0271|M.vanbaalenii_PYR-1       RQVAGGVDQLVEQVRVMADGLNQAAAFLLTMRHDAASANMAGFSIPAEVL
MAV_1761|M.avium_104                RQVADAVAQLVDKVKQLGAGLSESAAFLLSLKHDAAHPAMAGFNIPAQLL
MUL_0757|M.ulcerans_Agy99           QGLQDQMAAMQEDSSAMGEAFDSS-------------RNDDSFYLPPEVF
                                      :   :  : ..   :.  :  :                 .* :* : :

TH_2203|M.thermoresistible__bu      T------------------------QEEFAKAAEIFVSPDGHGVRYLVTT
MMAR_2342|M.marinum_M               A------------------------KDEFKKAAQIFISPDGHGARYLVQS
MAB_0855|M.abscessus_ATCC_1997      T------------------------QDSFKTAAAAFVSADGHAVRYLVQS
MSMEG_4741|M.smegmatis_MC2_155      T------------------------QEEFNKAAALFVSPDGRSVRYLVQT
Mb3853c|M.bovis_AF2122/97           SYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQT
Rv3823c|M.tuberculosis_H37Rv        SYATGESVKAETMPSEYRDLLGGLNVDQLKKVAAAFISPDGHSIRYLIQT
MLBr_01231|M.leprae_Br4923          ------------------------NTEDFKKLVQAFISPDGHSVRYFIQT
Mflv_0403|M.gilvum_PYR-GCK          G------------------------AVEFQKASEAFVSPDGHSVRYLVQT
Mvan_0271|M.vanbaalenii_PYR-1       N------------------------AVEFQKAAEAFISPDGHSVRYLVQT
MAV_1761|M.avium_104                R------------------------LPQFQEAAKVFISPDGHSVRYLVQS
MUL_0757|M.ulcerans_Agy99           N------------------------NPDFKRGLEQFLSPDGHAVRFIISH
                                                               .:      *:*.**:. *:::  

TH_2203|M.thermoresistible__bu      TLNPFSTEAMDLVNEITETARGARANTELAEADISMAGFTTTLRDTRDYY
MMAR_2342|M.marinum_M               ALNPFTTAAMDQVDEILDVAHDAQPNSELSDATISMVGIPTGLSDTRDYY
MAB_0855|M.abscessus_ATCC_1997      NLNPFSPEAMDQVRAIQEAARSAQPNTTLSDASISMAGLSAMYNDIRNYY
MSMEG_4741|M.smegmatis_MC2_155      ALDPFGTAAMDQVKDIVKTAESARPNTSLTDAKISLVGFSSIQNEMRNYY
Mb3853c|M.bovis_AF2122/97           DLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYS
Rv3823c|M.tuberculosis_H37Rv        DLNPFSTAAMDQIDAITAAARGAQPNTALADAKVSVVGLPVVLKDTRDYS
MLBr_01231|M.leprae_Br4923          DLNPFSSAAMDQVNTILNVATGAQPNTTLSDASIYLSGYTVTLRDTRDYY
Mflv_0403|M.gilvum_PYR-GCK          KLNPFSSEAMDQVNTISDIARGAQPNTMLSDASISMGGFPAALRDTRDYY
Mvan_0271|M.vanbaalenii_PYR-1       RLNPFSPEAMDQVNVINDIARGAQPNTSLADASISMGGFPAALRDTRDYY
MAV_1761|M.avium_104                KLSPFSTQAMDQVDAITATARGAQPNTALADAEVSMAGYTVGLKDTRDYY
MUL_0757|M.ulcerans_Agy99           EGDPMSQAGINHIDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGN
                                      .*:   .:: :  *   *  *  .: *  : : : *      :  :  

TH_2203|M.thermoresistible__bu      NNDFRLITTLTVVIVFLILVALLRAIVAPLYLIASVVISYLSALGLGVIL
MMAR_2342|M.marinum_M               NHDIQFIVFATILIVFLILVILLRAIVAPLYLIGSVLVSFLSALGLGVIV
MAB_0855|M.abscessus_ATCC_1997      NHDLRFIIVLTVIVVLLILVALLRAIVAPLYLIGSVIISYASAVGIGVIA
MSMEG_4741|M.smegmatis_MC2_155      DGDLRFIITVTLIVVFLILAALLRSIIAPIYLVLSVVLSYMSALGIGVVF
Mb3853c|M.bovis_AF2122/97           DHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIV
Rv3823c|M.tuberculosis_H37Rv        DHDLRLIIAMTVCIVLLILIVLLRAIVAPLYLIGSVIVSYLAALGIGVIV
MLBr_01231|M.leprae_Br4923          DRDLQLIVIVTMIVVLLILMALLRSIVAPIYLVGSVIVSYLSALGLCVLV
Mflv_0403|M.gilvum_PYR-GCK          ERDIRFIIVVTLVIVMLVLMLLLRSLIAPLYLVGSVVVSYFAAIGIGVLV
Mvan_0271|M.vanbaalenii_PYR-1       ERDIRFIIIAALIVVLVTLSVLLRSLVAPLYLVGSVVVSYFAAIGIGVLT
MAV_1761|M.avium_104                QHDIKFIIAVTLLVVLLTLMALLRAIVAPLYLVATVVISYLSAVGVGVLV
MUL_0757|M.ulcerans_Agy99           TFDLMIAGISALCLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLI
                                      *: :    :: :::: :  : *:::*.  :: :*::*  ::.*: *: 

TH_2203|M.thermoresistible__bu      FQYILGQELSWSVPGLTFIVLVAVGADYNMLLISRIREESPHGIRSGIIR
MMAR_2342|M.marinum_M               FQLILGKDLHWSLPGLSFILLVAVGADYNMLLISRIRDESPHGVRVGVIR
MAB_0855|M.abscessus_ATCC_1997      FQFIGGQPLSWSVPGMAFIVLVAVGADYNLLFISRIRDESPDGIRSGVIK
MSMEG_4741|M.smegmatis_MC2_155      FQFILGKEIVWTVPGMAFLVLVAVGADYNLLLISRIRDEAAHGMRTAVIR
Mb3853c|M.bovis_AF2122/97           FQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIR
Rv3823c|M.tuberculosis_H37Rv        FQFLLGQEMHWSIPGLTFVILVAVGADYNMLLISRLREEAVLGVRSGVIR
MLBr_01231|M.leprae_Br4923          FQVLLRQQLHWSVPGLAFVVLVAVGADYNMLLASRLRDESSHGLRASVIR
Mflv_0403|M.gilvum_PYR-GCK          FQLLLGQQLHWSVPPLAFVVLVAVGADYNMLFVSRMRDESPHSVRFGIIR
Mvan_0271|M.vanbaalenii_PYR-1       FQLLLGQQLHWSVPPLAFVVLVAVGADYNMLFVSRLRDESPHSVRYGVIR
MAV_1761|M.avium_104                FQFLLGQQLHWSVPPLAFVVLVAVGADYNMLLVSRMRDESPHSMRYGIIR
MUL_0757|M.ulcerans_Agy99           WQHVLGIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIR
                                    :* :    : * :  ::.::*:*******:*: :*:::*   .:. .:*:

TH_2203|M.thermoresistible__bu      TVGHTGGVITSAGLIFAASMFGLVFASITTMIQAGFILGVGLLLDTFLVR
MMAR_2342|M.marinum_M               TVGSTGGVITSAGLIFAASMFGLLAASITTMVEAGFIIGSGILIDTFLVR
MAB_0855|M.abscessus_ATCC_1997      TVKSTGGVITSAGVIFAASMFGLLIGNLQSMVEAGFIIGMGLLLDTFLVR
MSMEG_4741|M.smegmatis_MC2_155      TIGATGGVITSAGLIFAASMFGLTFSSLLAAVQIGFIIGVGLLLDTFLVR
Mb3853c|M.bovis_AF2122/97           TVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVR
Rv3823c|M.tuberculosis_H37Rv        TVASTGGVITAAGLIMAASMYGLVFASLGSVVQGAFVLGTGLLLDTFLVR
MLBr_01231|M.leprae_Br4923          TVRSTGGVITAAGLIFAASMFGLLLSSIATVVQAGFVLGSGILLDTFIVR
Mflv_0403|M.gilvum_PYR-GCK          TLGSTGGVITAAGLIFAASMAGLLFSSIGIVVQGGFVIGVGILLDTFVVR
Mvan_0271|M.vanbaalenii_PYR-1       TLGSTGGVITAAGLIFAASMAGLLFSSIGIVVQGGFVIGVGILLDTFVVR
MAV_1761|M.avium_104                TLSSTGGVITAAGLIFAASMSGLLFSSIGTVVQGGVVIGVGILLDTFLVR
MUL_0757|M.ulcerans_Agy99           AMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVR
                                    ::  :*.*:*:**:::* :* .:  ..:    : .  :* *:*:**::**

TH_2203|M.thermoresistible__bu      TITVPATAVLVGRANWWPAKPPHDG-------------------------
MMAR_2342|M.marinum_M               SVTVPAMAAMLGQANWWPSKIGASSTRRRVYQRAGSRKPNLLDRIKSLGP
MAB_0855|M.abscessus_ATCC_1997      TITIPALVVLCGQANWWPSASVESWFR----QRFSRSKPDAQE-----GD
MSMEG_4741|M.smegmatis_MC2_155      TITVPAAAVLIGKLSWWP------------------TKPPAP--------
Mb3853c|M.bovis_AF2122/97           TVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEE
Rv3823c|M.tuberculosis_H37Rv        TVTVPAIAVLVGQANWWLPSSWRPATWWPLGRRRGRAQRTKRKPLLPKEE
MLBr_01231|M.leprae_Br4923          TITVPAVAALLRRASWWPARPWGNNA------------------------
Mflv_0403|M.gilvum_PYR-GCK          TITVPAIATLLGRANWWPSRVA---APARERVSADT--------------
Mvan_0271|M.vanbaalenii_PYR-1       TITVPAIAALVGRANWWPSKVGPQQAAPRAVESAGSG-------------
MAV_1761|M.avium_104                TVTVPAIAALAGRANWWPSRIA----VRRNPVSGQP--------------
MUL_0757|M.ulcerans_Agy99           SFMTPSIAALLGKWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV------
                                    :.  *: ..:  :  **                                 

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               AKQRAAVTAKASTTTTKRPSTAVKKRGELVSKPGTRKRVRKPAWPDIPIT
MAB_0855|M.abscessus_ATCC_1997      CAVSDDPEAASGESSPEEPLISASREVELAGRR-----------------
MSMEG_4741|M.smegmatis_MC2_155      ------------EPAPTEPTVAPAAQA-----------------------
Mb3853c|M.bovis_AF2122/97           EEQSPPDDDDLIGLWLHDGLRL----------------------------
Rv3823c|M.tuberculosis_H37Rv        EEQSPPDDDDLIGLWLHDGLRL----------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               NDDYESLQEHALPLFGSIRLPRELTPIDPALHNGDGATSNGDGTTNGSGA
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               DCKQLQLIGLGDTTEFRVPNGTTNGNGNGNGHTNGNGHTNGNGHTNGNGH
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               TNGTNGHGTNGATNGNGHTNGTNGTNGHGTNGATNGHTNGTNGNGHTNGT
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               NGHGTNGATNGNGHTNGTNGTNGHGTNGATNGHTNGNGNGTNGNGNGTNG
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               HGTNGHTNGNGTNGATNGASNGATNGTNGHTNGNGNGNGTNGHTSGNGNG
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               TNGATNGASNGATNGTNGHTNGNGNGTNGATNGHTNGNGNGTNGHTSGNG
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      --------------------------------------------------
MMAR_2342|M.marinum_M               NGTNGATNGASNGATNGTNGHTNGNGNGNGTNGATNEHGTNGSTNGDIDD
MAB_0855|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_4741|M.smegmatis_MC2_155      --------------------------------------------------
Mb3853c|M.bovis_AF2122/97           --------------------------------------------------
Rv3823c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01231|M.leprae_Br4923          --------------------------------------------------
Mflv_0403|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_0271|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_1761|M.avium_104                --------------------------------------------------
MUL_0757|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

TH_2203|M.thermoresistible__bu      ----------------------
MMAR_2342|M.marinum_M               ADEGHALPLFGPSNQRDLLIKR
MAB_0855|M.abscessus_ATCC_1997      ----------------------
MSMEG_4741|M.smegmatis_MC2_155      ----------------------
Mb3853c|M.bovis_AF2122/97           ----------------------
Rv3823c|M.tuberculosis_H37Rv        ----------------------
MLBr_01231|M.leprae_Br4923          ----------------------
Mflv_0403|M.gilvum_PYR-GCK          ----------------------
Mvan_0271|M.vanbaalenii_PYR-1       ----------------------
MAV_1761|M.avium_104                ----------------------
MUL_0757|M.ulcerans_Agy99           ----------------------