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M. thermoresistible (build 8) TH_3407 (-)

annotation: AMP-dependent synthetase and ligase
coordinates: 2501622 - 2503130
length: 503

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_3407 - - 100% (503) AMP-dependent synthetase and ligase
M. thermoresistible (build 8) TH_4613 - 2e-64 33.40% (500) PUTATIVE AMP-dependent synthetase and ligase
M. thermoresistible (build 8) TH_3085 - 4e-57 32.60% (503) PUTATIVE AMP-dependent synthetase and ligase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0220 fadD4 5e-61 31.94% (501) acyl-CoA synthetase
M. gilvum PYR-GCK Mflv_0419 - 0.0 73.43% (493) AMP-dependent synthetase and ligase
M. tuberculosis H37Rv Rv0214 fadD4 5e-61 31.94% (501) acyl-CoA synthetase
M. leprae Br4923 MLBr_02546 fadD2 5e-47 30.26% (499) acyl-CoA synthetase
M. abscessus ATCC 19977 MAB_2316 - 1e-124 47.84% (485) acid-CoA ligase
M. marinum M MMAR_3983 - 8e-72 37.32% (493) fatty-acid-CoA ligase
M. avium 104 MAV_1627 - 5e-74 36.25% (491) feruloyl-CoA synthetase
M. smegmatis MC2 155 MSMEG_0318 - 0.0 75.41% (488) AMP-dependent synthetase and ligase
M. ulcerans Agy99 MUL_3844 - 9e-72 36.98% (503) fatty-acid-CoA ligase
M. vanbaalenii PYR-1 Mvan_0252 - 0.0 74.64% (489) AMP-dependent synthetase and ligase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0220|M.bovis_AF2122/97            ----MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPY--------
Rv0214|M.tuberculosis_H37Rv         ----MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPY--------
TH_3407|M.thermoresistible__bu      -----------------MADTT-DVPGTPVPPIGTRFAALAQ--------
MSMEG_0318|M.smegmatis_MC2_155      -----------------MTDK-----GFDVPPIGTQVAHLAA--------
Mflv_0419|M.gilvum_PYR-GCK          -----------------MTEGQASAVDAPVPPISTQVSALAA--------
Mvan_0252|M.vanbaalenii_PYR-1       -----------------MTA-------APVPPIGTQVSALAA--------
MAB_2316|M.abscessus_ATCC_1997      -----------------MAVMT---DAAVGEPFVRILANLAD--------
MMAR_3983|M.marinum_M               ------------MSTQPMGPGATTNPLADGVPFGTRLEELAE--------
MUL_3844|M.ulcerans_Agy99           ------------MSTQPMGPGTTTNPLADGVPFGTRLEELAE--------
MAV_1627|M.avium_104                -------------MTESAPAELAANPLADGIPFGAKLQQLAG--------
MLBr_02546|M.leprae_Br4923          MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
                                                                   .        .         

Mb0220|M.bovis_AF2122/97            --IAADKPAVILYPSG---TVISFDELEARANRLAHWFRQAGLREDDVVA
Rv0214|M.tuberculosis_H37Rv         --IGADKPAVILYPSG---TVISFDELEARANRLAHWFRQAGLREDDVVA
TH_3407|M.thermoresistible__bu      --TDPTAPAVSCAG-----VTLTRRELDASTNRLARAFAELGVGQGDYVT
MSMEG_0318|M.smegmatis_MC2_155      --ADPDRPAVSCQG-----RTLSRGELDRSTNRLARAYAELGVRQGDYVT
Mflv_0419|M.gilvum_PYR-GCK          --RSPDAAAITCAG-----RTVTRAELDATSNRIARGFASRGVGIGDYVT
Mvan_0252|M.vanbaalenii_PYR-1       --QAPDAPAATCDG-----VTVTRRELDATSNRLARAFASLGVGVGDYVT
MAB_2316|M.abscessus_ATCC_1997      --AEPDAPAVTCGT-----DSVTRAELERRATALAHAYQRLGVRQGDLVT
MMAR_3983|M.marinum_M               --QRRDETAVTIVAPDGSTQSMTFGELDCLANQWGRTLAAHGAQTGSLVA
MUL_3844|M.ulcerans_Agy99           --QRRDETAVTIVAPEGSTQSMTFGELDRLANQWGRTLAAHGAQTGSLVA
MAV_1627|M.avium_104                --QRGDDTAVTVVALDGTATSLTFAELDARANQWGRALAATGAQTGSLVA
MLBr_02546|M.leprae_Br4923          LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
                                            :            ::  **:  :   ..     *   .. ::

Mb0220|M.bovis_AF2122/97            ILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGS
Rv0214|M.tuberculosis_H37Rv         ILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGS
TH_3407|M.thermoresistible__bu      ISLFNSIEWLQATLAVWKLGAIPQPLSPRLPDPEFAELLALRRRALLVGR
MSMEG_0318|M.smegmatis_MC2_155      ICLHNSIEWVQATLATWKLGAVPQPLSPRMPDAEFEAILGLKRRALVVGR
Mflv_0419|M.gilvum_PYR-GCK          IVLPNSIDWAYAVLACWKLGAVPQPLSARMPDAELGALLQLRRPALLVGR
Mvan_0252|M.vanbaalenii_PYR-1       IVLPNSLDWAYSVLACWKLGAVPQPLSARLPDAELAALLELRRPALLVGR
MAB_2316|M.abscessus_ATCC_1997      IGLPNSVEFFAAQIAVWKLGATPQPVSWRLPLAERRAIVELADSTLVVGV
MMAR_3983|M.marinum_M               LAIPNSQHLVLATLGCWKIGAVPIPMHWDLPEWERDRVRAVIDPAVIVDE
MUL_3844|M.ulcerans_Agy99           LAIPNSQHLVLATLGCWKIGAVPIPMHWDLPEWERDRVRAVIDPAVIVDE
MAV_1627|M.avium_104                LAIPNSQHLVLATLGCWKIGAVPVPMHWDLPEWERDRVREVINPAVVVDE
MLBr_02546|M.leprae_Br4923          ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
                                    :   *         .  : *     :   :.  :   :        ::  

Mb0220|M.bovis_AF2122/97            AALRETCHGLAEHL--PGGLPDLLMLAGGGLVGWMTYPECVADQPDTPIE
Rv0214|M.tuberculosis_H37Rv         AALRETCHGLAEHL--PGGLPDLLMLAGGGLVGWMTYPECVADQPDTPIE
TH_3407|M.thermoresistible__bu      PAPDGS-----------IPHVPAGFT-PDPALSDGPLPEAVSPVLKS---
MSMEG_0318|M.smegmatis_MC2_155      -DPGGD-----------ISWVPGDFE-PGPGLADDPLPEAVSPTWKS---
Mflv_0419|M.gilvum_PYR-GCK          TDPTGL-----------TAGTTTDLAREFADESDAALPEAVSPVWKA---
Mvan_0252|M.vanbaalenii_PYR-1       PDPTGV-----------TPDVAVELAAEFPD---SPLPEAVSPVWKS---
MAB_2316|M.abscessus_ATCC_1997      DPADHPD----------RVCVSAGFEPGAEDYLAGPVPEVVSPAWKA---
MMAR_3983|M.marinum_M               HNRWRL-------------------QAHAAGESRDPLPAAVSPTANG---
MUL_3844|M.ulcerans_Agy99           HNRWRL-------------------QAHAAGESRDPLPTAVSPTANG---
MAV_1627|M.avium_104                TNRWGL-------------------EARAAGESEAALPVAVSPTANG---
MLBr_02546|M.leprae_Br4923          DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAP
                                                                       . .  ::   .    

Mb0220|M.bovis_AF2122/97            DERE-GDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADS
Rv0214|M.tuberculosis_H37Rv         DERE-GDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADS
TH_3407|M.thermoresistible__bu      ---------MASGGSTGRPKLIESGGDARVP-PVIGTPLG-----AEPGD
MSMEG_0318|M.smegmatis_MC2_155      ---------IASGGSTGRPKLIEAGGDGRVP-ALIGAPLG-----AEPDD
Mflv_0419|M.gilvum_PYR-GCK          ---------MASGGSTGRPKLIEAGNDSRVP-PAIGYPLG-----AQEGD
Mvan_0252|M.vanbaalenii_PYR-1       ---------MASGGSTGRPKLIEAGNDSRVP-PAIGYPLG-----AQEGD
MAB_2316|M.abscessus_ATCC_1997      ---------PTSGGSTGRPKIIVAPTPAVITGTAAGEIMG-----MQHAD
MMAR_3983|M.marinum_M               ---------ICSSGSTGVPKVILNLAPSLWT-PQHGEPFLSAWTPVAQPQ
MUL_3844|M.ulcerans_Agy99           ---------ICSSGSTGVPKVILNLAPSLWT-PEHGEPFLSAWTPVAQPQ
MAV_1627|M.avium_104                ---------ICSSGSTGVPKVILNLAPSLWI-PQHGEPFLSNWTPVAQPQ
MLBr_02546|M.leprae_Br4923          KVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVP----FRAHE
                                               :.*:** **                             .

Mb0220|M.bovis_AF2122/97            VYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHA
Rv0214|M.tuberculosis_H37Rv         VYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHA
TH_3407|M.thermoresistible__bu      VNLISVPLSHNTGFTTAVIGLVQGHHLVLMPRFDAAEFLRLVTDFRVTWL
MSMEG_0318|M.smegmatis_MC2_155      VTLMSVPMSHNTGFTTFAIALLMGQHLVLMPRFEPAEFLRLVTSHRVTFL
Mflv_0419|M.gilvum_PYR-GCK          VNLVSVPLSHNTGFTTFAIGLLQGHHLVVMPRFEPREFLRLITEHRVTFL
Mvan_0252|M.vanbaalenii_PYR-1       VTLVSVPLSHNTGFTTFAVGLLQGHHLVVMPRFEPHEFLRLVTEHRVTFL
MAB_2316|M.abscessus_ATCC_1997      AQLVAGPLYHNAPLMFSSYGLLLGHHLVVQPKFDALEALELIGTHKVTWL
MMAR_3983|M.marinum_M               TIMVPAPMYHTNGFATFLM-LLGGDHLVVLERFDAALVVDVIERFRVTNF
MUL_3844|M.ulcerans_Agy99           TIMVPAPMYHTNGFATFMM-LLGGDHLVVLEKFDAALVVDVIERFRVTNF
MAV_1627|M.avium_104                TIMVPAPMYHTNGFAPLLM-LLGGDHLVILEKFDAALVLDVIERFRITNF
MLBr_02546|M.leprae_Br4923          VTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQATAM
                                    . : . *: *          :  *   *:  :*..   :  :  .: *  

Mb0220|M.bovis_AF2122/97            QFVPAMFVRMLKLPEAVR----NSYDMSSLRRVIHAAAPCPVQIKEQMIH
Rv0214|M.tuberculosis_H37Rv         QFVPAMFVRMLKLPEAVR----NSYDMSSLRRVIHAAAPCPVQIKEQMIH
TH_3407|M.thermoresistible__bu      TTVPTIMQRLLPVYRAAAAADPGRYDLSSLRRFWHVGAPCPPAVKEAWIE
MSMEG_0318|M.smegmatis_MC2_155      TTVPTIMQRLLPVYR----AEPDAYDLTSIRRFWHVGAPCPPAVKQAWID
Mflv_0419|M.gilvum_PYR-GCK          TTVPTIMQRLLPVYR----ADPDAYDLSSIRRFWHVASACPPAVKRAWID
Mvan_0252|M.vanbaalenii_PYR-1       TTVPTIMQRLLPVYR----ADPDAYDLSSIRRFWHLAAPCPPAVKHAWIE
MAB_2316|M.abscessus_ATCC_1997      QVVPTMMSRMLRELR----QHPGRFDLSTIRVLWHMAAPCPVWLKQAWID
MMAR_3983|M.marinum_M               TATPTMLARIAAIPG------IRQRDLSSIVFILQGAAVMPPSLLHTWFE
MUL_3844|M.ulcerans_Agy99           TATPTMLARIAAIPG------IRQRDLSSIVFILQGAAVMPPSLLHTWFE
MAV_1627|M.avium_104                TATPTMLARIAARPD------VRQRDLSSIVFILQGAAVMPPSLLHTWFE
MLBr_02546|M.leprae_Br4923          VVVPVMLSRILDTLEN----LETKSDLSSLRVVFVSGSQLGAELATRALE
                                      .*.:: *:               *::::  .   .:     :    :.

Mb0220|M.bovis_AF2122/97            WWGP-IIDEYYASSEASGSTLITAEDWLTHPGSVGKPIQG-GVHIVGADG
Rv0214|M.tuberculosis_H37Rv         WWGP-IIDEYYASSEASGSTLITAEDWLTHPGSVGKPIQG-GVHIVGADG
TH_3407|M.thermoresistible__bu      ILGPQVLWELYGGTELQALTFISGEQWLSHRGSVGVVVSG-EMKVLDDDG
MSMEG_0318|M.smegmatis_MC2_155      LLGPQVVWELYGGTELQALTFISGEQWLTHPGSVGVVVAG-EMKVLDDDG
Mflv_0419|M.gilvum_PYR-GCK          IVGPDALWELYGGTELQALTFISGTQWLTHPGSVGVVVAG-EMKVLDDDG
Mvan_0252|M.vanbaalenii_PYR-1       LLGPDAVWELYGGTELQALTFISGDQWLTHPGSVGVVVAG-EMKVLDDDG
MAB_2316|M.abscessus_ATCC_1997      LLGPEVIWELYAGTEAIGGTIITGQEWLAHRGSVGKPALG-ELAILDENG
MMAR_3983|M.marinum_M               LLGPEKIVTAYGMTENLGLTALRGDEWVSHPGSVGRGFRETEIQILDSQQ
MUL_3844|M.ulcerans_Agy99           LLGPEKIVTAYGMTENLGLTALRGDEWVSHPGSVGRGFRETEIQILDSQQ
MAV_1627|M.avium_104                LLSPEQIVMAYGMTENLGLTALRGDEWLEHPGSVGRGFRDTEIRILDSQQ
MLBr_02546|M.leprae_Br4923          ELGP-VIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKGVKVKILDDSG
                                      .*  :   *. :*    *     :   : .:**       : ::. . 

Mb0220|M.bovis_AF2122/97            SELPPNQPGEIYFEGG--YPFEYLNDPAKTAASRNKHGWVTVGDVGYLDD
Rv0214|M.tuberculosis_H37Rv         SELPPNQPGEIYFEGG--YPFEYLNDPAKTAASRNKHGWVTVGDVGYLDD
TH_3407|M.thermoresistible__bu      NECPPVVVGEIYMRPSPGSGPTYRYVG---ATAKSRDGWDSLGDLGYFDE
MSMEG_0318|M.smegmatis_MC2_155      NECPPGVTGEVYMRPSPGSTPTYRYVG---TTAKSRDGWDSLGDLGYFDT
Mflv_0419|M.gilvum_PYR-GCK          NECPPGVPGEIYMRPAPGARPTYRYIG---STAKSRDGWDSLGDLGYFDE
Mvan_0252|M.vanbaalenii_PYR-1       DECPPGVAGEIYMRSAPGGPPTYRYVG---STAKSRDGWESLGDLGYFDE
MAB_2316|M.abscessus_ATCC_1997      NPLPAGEVGEIFMRPWEGMPTPYKYLG---AEIKRFGTWESIGDLGWLDD
MMAR_3983|M.marinum_M               QPVGPGEHGDVYLRAP--MSAGYRYLGGAPPLPSTGEGYRCAGDIGYLDE
MUL_3844|M.ulcerans_Agy99           QPVGPGEHGDVYLRAP--MSAGYRYLGGAPPLPSTGEGYRCAGDIGYLDE
MAV_1627|M.avium_104                RPLGPGEDGDVYLRAP--MSAGYRYLGGAPPLPSTEDGFRSAGDIGHLDE
MLBr_02546|M.leprae_Br4923          KEVPRGQVGRIFVGNAFPFEGYTGGGG-----KQIIDGLLSSGDVGYFDE
                                            * ::.                             **:* :* 

Mb0220|M.bovis_AF2122/97            DGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMG
Rv0214|M.tuberculosis_H37Rv         DGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMG
TH_3407|M.thermoresistible__bu      DGFLYLSDRRVDMFTVGGRNVYPAEVESALAEHPEVLSALVVGIPDDDLG
MSMEG_0318|M.smegmatis_MC2_155      DGFLYLNDRRVDMFTVGGRNVYPAEIEAALSAHPEVLSCLAVGIPHTDLG
Mflv_0419|M.gilvum_PYR-GCK          DGFLYLNDRRVDMFTVGGRNVYPAEIESALAEHPGVLSSLVVGLPDDDLG
Mvan_0252|M.vanbaalenii_PYR-1       DGFLYLNDRRVDMFTVGGRNVYPAEIESALAEHPRVLSSLAMGLPDDDLG
MAB_2316|M.abscessus_ATCC_1997      DGYLYMSDRRTDLIVTGGANVFPAEVESVMNGYPGVIDSVVVGLPDDDLG
MMAR_3983|M.marinum_M               DGYLYIVDRRVDMIVTGGANVFPAEVESALAGHPGIADVVVIGIADARWG
MUL_3844|M.ulcerans_Agy99           DGYLYIVDRRVDMIITGGANVFPAEVESALAGHPGIADVVVIGIADARWG
MAV_1627|M.avium_104                DGYLYIVDRRVDMIISGGANVFPAEVESALAGHPAIADVVVIGLADPQWG
MLBr_02546|M.leprae_Br4923          HDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEWG
                                    .. *:: .*  .::  ** *::* * *  :  :* : .  ..*: .   *

Mb0220|M.bovis_AF2122/97            QRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTD
Rv0214|M.tuberculosis_H37Rv         QRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTD
TH_3407|M.thermoresistible__bu      QVPYAIVHTAD---GSDLDEAAVIGFLRERIAGYKVPRHVEFSATPVRDD
MSMEG_0318|M.smegmatis_MC2_155      QVPHALVQTAP---GSTLDAAGLRDFLRDAVSSYKVPHTIEFVDEPLRDD
Mflv_0419|M.gilvum_PYR-GCK          HVPHAIVQAD-------LSEADVLAFLGERIASYKLPRTVEFTDRPLRDD
Mvan_0252|M.vanbaalenii_PYR-1       QVPHAIVQAHG------LDEAEVIAFLAERIASHKLPRSVEFTDRPLRDD
MAB_2316|M.abscessus_ATCC_1997      QSVHAVVHAEP---N--VTEDQLRDYLLDQIVRYKVPRTIEFVADPLRED
MMAR_3983|M.marinum_M               RRVHAVVQVA-----APLTEQQVIEYAKNRLAPYKVPKTVEFVDRIPRTA
MUL_3844|M.ulcerans_Agy99           RRVHAVVQVA-----APLTEQQVIEYAKNRLAPYKVPKTVEFVDQIPRTA
MAV_1627|M.avium_104                RRVHAVVQRAD---GASLTEQQVIDYAKGRLAPYKAPKTVEFVDAIPRTA
MLBr_02546|M.leprae_Br4923          ARLRAFVVKKQ---DATIDEDAIKAYVRDHLARYKVPREVIFLEELPRNP
                                        * *               :  :    :  .* *: : *     *  

Mb0220|M.bovis_AF2122/97            TGKLYKSGLVEKYSV---------
Rv0214|M.tuberculosis_H37Rv         TGKLYKSGLVEKYSV---------
TH_3407|M.thermoresistible__bu      AGKARRSAVRDEVIARSASRRS--
MSMEG_0318|M.smegmatis_MC2_155      AGKARRTAVRDAVIARLGRAPAAR
Mflv_0419|M.gilvum_PYR-GCK          AGKARRSAVRDEVLARRA------
Mvan_0252|M.vanbaalenii_PYR-1       AGKARRSAVRDEVIARRSS-----
MAB_2316|M.abscessus_ATCC_1997      SGKVRRSLIREQATARRAAAG---
MMAR_3983|M.marinum_M               ATKVNRSAM---IAARGG------
MUL_3844|M.ulcerans_Agy99           ATKVNRSAM---IAARGG------
MAV_1627|M.avium_104                ATKVNRSAM---IAARGG------
MLBr_02546|M.leprae_Br4923          TGKVLKRELRDFEVH---------
                                    : *  :  :

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_3407	-	-	100% (503)	AMP-dependent synthetase and ligase
M. thermoresistible (build 8)	TH_4613	-	2e-64	33.40% (500)	PUTATIVE AMP-dependent synthetase and ligase
M. thermoresistible (build 8)	TH_3085	-	4e-57	32.60% (503)	PUTATIVE AMP-dependent synthetase and ligase