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TESAPAELAANPLADGIPFGAKLQQLAGQRGDDTAVTVVALDGTATSLTFAELDARANQWGRALAATGAQ TGSLVALAIPNSQHLVLATLGCWKIGAVPVPMHWDLPEWERDRVREVINPAVVVDETNRWGLEARAAGES EAALPVAVSPTANGICSSGSTGVPKVILNLAPSLWIPQHGEPFLSNWTPVAQPQTIMVPAPMYHTNGFAP LLMLLGGDHLVILEKFDAALVLDVIERFRITNFTATPTMLARIAARPDVRQRDLSSIVFILQGAAVMPPS LLHTWFELLSPEQIVMAYGMTENLGLTALRGDEWLEHPGSVGRGFRDTEIRILDSQQRPLGPGEDGDVYL RAPMSAGYRYLGGAPPLPSTEDGFRSAGDIGHLDEDGYLYIVDRRVDMIISGGANVFPAEVESALAGHPA IADVVVIGLADPQWGRRVHAVVQRADGASLTEQQVIDYAKGRLAPYKAPKTVEFVDAIPRTAATKVNRSA MIAARGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1627 | - | - | 100% (498) | feruloyl-CoA synthetase |
| M. avium 104 | MAV_4961 | - | 4e-56 | 31.59% (497) | acyl-CoA synthetase |
| M. avium 104 | MAV_5098 | - | 6e-54 | 31.07% (486) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 4e-50 | 30.21% (480) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_0419 | - | 4e-80 | 37.78% (487) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 4e-50 | 30.21% (480) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-47 | 29.35% (477) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2316 | - | 3e-74 | 38.79% (495) | acid-CoA ligase |
| M. marinum M | MMAR_3983 | - | 0.0 | 85.42% (487) | fatty-acid-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_0318 | - | 1e-70 | 35.86% (488) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3407 | - | 4e-74 | 36.25% (491) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3844 | - | 0.0 | 85.22% (487) | fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_0252 | - | 1e-78 | 38.02% (484) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3983|M.marinum_M ------------MSTQPMGPGATTNPLADGVPFGTRLEELAE--------
MUL_3844|M.ulcerans_Agy99 ------------MSTQPMGPGTTTNPLADGVPFGTRLEELAE--------
MAV_1627|M.avium_104 -------------MTESAPAELAANPLADGIPFGAKLQQLAG--------
MSMEG_0318|M.smegmatis_MC2_155 -----------------MTDK-----GFDVPPIGTQVAHLAA--------
TH_3407|M.thermoresistible__bu -----------------MADTT-DVPGTPVPPIGTRFAALAQ--------
Mflv_0419|M.gilvum_PYR-GCK -----------------MTEGQASAVDAPVPPISTQVSALAA--------
Mvan_0252|M.vanbaalenii_PYR-1 -----------------MTA-------APVPPIGTQVSALAA--------
MAB_2316|M.abscessus_ATCC_1997 -----------------MAVMT---DAAVGEPFVRILANLAD--------
Mb3116|M.bovis_AF2122/97 -----------------------------MKNIGWMLRQRAT--------
Rv3089|M.tuberculosis_H37Rv -----------------------------MKNIGWMLRQRAT--------
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
: *
MMAR_3983|M.marinum_M --QRRDETAVTIVAPDGSTQSMTFGELDCLANQWGRTLAAHGAQTGSLVA
MUL_3844|M.ulcerans_Agy99 --QRRDETAVTIVAPEGSTQSMTFGELDRLANQWGRTLAAHGAQTGSLVA
MAV_1627|M.avium_104 --QRGDDTAVTVVALDGTATSLTFAELDARANQWGRALAATGAQTGSLVA
MSMEG_0318|M.smegmatis_MC2_155 --ADPDRPAVSCQG-----RTLSRGELDRSTNRLARAYAELGVRQGDYVT
TH_3407|M.thermoresistible__bu --TDPTAPAVSCAG-----VTLTRRELDASTNRLARAFAELGVGQGDYVT
Mflv_0419|M.gilvum_PYR-GCK --RSPDAAAITCAG-----RTVTRAELDATSNRIARGFASRGVGIGDYVT
Mvan_0252|M.vanbaalenii_PYR-1 --QAPDAPAATCDG-----VTVTRRELDATSNRLARAFASLGVGVGDYVT
MAB_2316|M.abscessus_ATCC_1997 --AEPDAPAVTCGT-----DSVTRAELERRATALAHAYQRLGVRQGDLVT
Mb3116|M.bovis_AF2122/97 --VSPRLQAYVEPS---TDVRMTYAQMNALANRCADVLTALGIAKGDRVA
Rv3089|M.tuberculosis_H37Rv --VSPRLQAYVEPS---TDVRMTYAQMNALANRCADVLTALGIAKGDRVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
: :: ::: : . * *. ::
MMAR_3983|M.marinum_M LAIPNSQHLVLATLGCWKIGAVPIPMHWDLPEWERDRVRAVIDPAVIVDE
MUL_3844|M.ulcerans_Agy99 LAIPNSQHLVLATLGCWKIGAVPIPMHWDLPEWERDRVRAVIDPAVIVDE
MAV_1627|M.avium_104 LAIPNSQHLVLATLGCWKIGAVPVPMHWDLPEWERDRVREVINPAVVVDE
MSMEG_0318|M.smegmatis_MC2_155 ICLHNSIEWVQATLATWKLGAVPQPLSPRMPDAEFEAILGLKRRALVVGR
TH_3407|M.thermoresistible__bu ISLFNSIEWLQATLAVWKLGAIPQPLSPRLPDPEFAELLALRRRALLVGR
Mflv_0419|M.gilvum_PYR-GCK IVLPNSIDWAYAVLACWKLGAVPQPLSARMPDAELGALLQLRRPALLVGR
Mvan_0252|M.vanbaalenii_PYR-1 IVLPNSLDWAYSVLACWKLGAVPQPLSARLPDAELAALLELRRPALLVGR
MAB_2316|M.abscessus_ATCC_1997 IGLPNSVEFFAAQIAVWKLGATPQPVSWRLPLAERRAIVELADSTLVVGV
Mb3116|M.bovis_AF2122/97 LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
Rv3089|M.tuberculosis_H37Rv LLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYG
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * . ::** : :. : : :::
MMAR_3983|M.marinum_M HNRWRL-------------------------------QAHAAGESRDPLP
MUL_3844|M.ulcerans_Agy99 HNRWRL-------------------------------QAHAAGESRDPLP
MAV_1627|M.avium_104 TNRWGL-------------------------------EARAAGESEAALP
MSMEG_0318|M.smegmatis_MC2_155 -DPGGD-----------------------ISWVPGDFE-PGPGLADDPLP
TH_3407|M.thermoresistible__bu PAPDGS-----------------------IPHVPAGFT-PDPALSDGPLP
Mflv_0419|M.gilvum_PYR-GCK TDPTGL-----------------------TAGTTTDLAREFADESDAALP
Mvan_0252|M.vanbaalenii_PYR-1 PDPTGV-----------------------TPDVAVELAAEFPD---SPLP
MAB_2316|M.abscessus_ATCC_1997 DPADHPD----------------------RVCVSAGFEPGAEDYLAGPVP
Mb3116|M.bovis_AF2122/97 APSAPVIDAIRAQADPPGTV------TDWIGADSLAERLRSAAADEPAVE
Rv3089|M.tuberculosis_H37Rv APSAPVIDAIRAQADPPGTV------TDWIGADSLAERLRSAAADEPAVE
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAP
.
MMAR_3983|M.marinum_M AAVSPTANGICSSGSTGVPKVILNLAPSLWT-PQHGEPFLSAWTPVAQPQ
MUL_3844|M.ulcerans_Agy99 TAVSPTANGICSSGSTGVPKVILNLAPSLWT-PEHGEPFLSAWTPVAQPQ
MAV_1627|M.avium_104 VAVSPTANGICSSGSTGVPKVILNLAPSLWI-PQHGEPFLSNWTPVAQPQ
MSMEG_0318|M.smegmatis_MC2_155 EAVSPTWKSIASGGSTGRPKLIEAGGDGRVP-ALIGAPLG-----AEPDD
TH_3407|M.thermoresistible__bu EAVSPVLKSMASGGSTGRPKLIESGGDARVP-PVIGTPLG-----AEPGD
Mflv_0419|M.gilvum_PYR-GCK EAVSPVWKAMASGGSTGRPKLIEAGNDSRVP-PAIGYPLG-----AQEGD
Mvan_0252|M.vanbaalenii_PYR-1 EAVSPVWKSMASGGSTGRPKLIEAGNDSRVP-PAIGYPLG-----AQEGD
MAB_2316|M.abscessus_ATCC_1997 EVVSPAWKAPTSGGSTGRPKIIVAPTPAVITGTAAGEIMG-----MQHAD
Mb3116|M.bovis_AF2122/97 CGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTID----VRYRD
Rv3089|M.tuberculosis_H37Rv CGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTID----VRYRD
MLBr_02546|M.leprae_Br4923 KVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVP----FRAHE
. :.*:** ** . :
MMAR_3983|M.marinum_M TIMVPAPMYHTNGFATFLM-LLGGDHLVVLERFDAALVVDVIERFRVTNF
MUL_3844|M.ulcerans_Agy99 TIMVPAPMYHTNGFATFMM-LLGGDHLVVLEKFDAALVVDVIERFRVTNF
MAV_1627|M.avium_104 TIMVPAPMYHTNGFAPLLM-LLGGDHLVILEKFDAALVLDVIERFRITNF
MSMEG_0318|M.smegmatis_MC2_155 VTLMSVPMSHNTGFTTFAIALLMGQHLVLMPRFEPAEFLRLVTSHRVTFL
TH_3407|M.thermoresistible__bu VNLISVPLSHNTGFTTAVIGLVQGHHLVLMPRFDAAEFLRLVTDFRVTWL
Mflv_0419|M.gilvum_PYR-GCK VNLVSVPLSHNTGFTTFAIGLLQGHHLVVMPRFEPREFLRLITEHRVTFL
Mvan_0252|M.vanbaalenii_PYR-1 VTLVSVPLSHNTGFTTFAVGLLQGHHLVVMPRFEPHEFLRLVTEHRVTFL
MAB_2316|M.abscessus_ATCC_1997 AQLVAGPLYHNAPLMFSSYGLLLGHHLVVQPKFDALEALELIGTHKVTWL
Mb3116|M.bovis_AF2122/97 RLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIG
Rv3089|M.tuberculosis_H37Rv RLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIG
MLBr_02546|M.leprae_Br4923 VTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQATAM
::. *: * . * *: :*.. : :
MMAR_3983|M.marinum_M TATPTMLARIAAIPG------IRQRDLSSIVFILQGAAVMPPSLLHTWFE
MUL_3844|M.ulcerans_Agy99 TATPTMLARIAAIPG------IRQRDLSSIVFILQGAAVMPPSLLHTWFE
MAV_1627|M.avium_104 TATPTMLARIAARPD------VRQRDLSSIVFILQGAAVMPPSLLHTWFE
MSMEG_0318|M.smegmatis_MC2_155 TTVPTIMQRLLPVYR----AEPDAYDLTSIRRFWHVGAPCPPAVKQAWID
TH_3407|M.thermoresistible__bu TTVPTIMQRLLPVYRAAAAADPGRYDLSSLRRFWHVGAPCPPAVKEAWIE
Mflv_0419|M.gilvum_PYR-GCK TTVPTIMQRLLPVYR----ADPDAYDLSSIRRFWHVASACPPAVKRAWID
Mvan_0252|M.vanbaalenii_PYR-1 TTVPTIMQRLLPVYR----ADPDAYDLSSIRRFWHLAAPCPPAVKHAWIE
MAB_2316|M.abscessus_ATCC_1997 QVVPTMMSRMLRELR----QHPGRFDLSTIRVLWHMAAPCPVWLKQAWID
Mb3116|M.bovis_AF2122/97 GAVPAILNFMRQVPE------FAELDAPDFRYFITGGAPMPEALIKIYAA
Rv3089|M.tuberculosis_H37Rv GAVPAILNFMRQVPE------FAELDAPDFRYFITGGAPMPEALIKIYAA
MLBr_02546|M.leprae_Br4923 VVVPVMLSRILDTLEN----LETKSDLSSLRVVFVSGSQLGAELATRALE
..*.:: : * . : . .: :
MMAR_3983|M.marinum_M LLGPEKIVTAYGMTENLG-LTALRGDEWVSHPGSVGRGFRETEIQILDSQ
MUL_3844|M.ulcerans_Agy99 LLGPEKIVTAYGMTENLG-LTALRGDEWVSHPGSVGRGFRETEIQILDSQ
MAV_1627|M.avium_104 LLSPEQIVMAYGMTENLG-LTALRGDEWLEHPGSVGRGFRDTEIRILDSQ
MSMEG_0318|M.smegmatis_MC2_155 LLGPQVVWELYGGTELQA-LTFISGEQWLTHPGSVGVVVAG-EMKVLDDD
TH_3407|M.thermoresistible__bu ILGPQVLWELYGGTELQA-LTFISGEQWLSHRGSVGVVVSG-EMKVLDDD
Mflv_0419|M.gilvum_PYR-GCK IVGPDALWELYGGTELQA-LTFISGTQWLTHPGSVGVVVAG-EMKVLDDD
Mvan_0252|M.vanbaalenii_PYR-1 LLGPDAVWELYGGTELQA-LTFISGDQWLTHPGSVGVVVAG-EMKVLDDD
MAB_2316|M.abscessus_ATCC_1997 LLGPEVIWELYAGTEAIG-GTIITGQEWLAHRGSVGKPALG-ELAILDEN
Mb3116|M.bovis_AF2122/97 KN--IEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDD
Rv3089|M.tuberculosis_H37Rv KN--IEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDD
MLBr_02546|M.leprae_Br4923 ELG-PVIYNMYGSTEIAF-ATIAGPKDLQINSATVGPVVKGVKVKILDDS
: *. ** * : : .:.* .: : ...
MMAR_3983|M.marinum_M QQPVGPGEHGDVYLRAP--MSAGYRYLGGAPPLPSTGEGYRCAGDIGYLD
MUL_3844|M.ulcerans_Agy99 QQPVGPGEHGDVYLRAP--MSAGYRYLGGAPPLPSTGEGYRCAGDIGYLD
MAV_1627|M.avium_104 QRPLGPGEDGDVYLRAP--MSAGYRYLGGAPPLPSTEDGFRSAGDIGHLD
MSMEG_0318|M.smegmatis_MC2_155 GNECPPGVTGEVYMRPSPGSTPTYRYVG---TTAKSRDGWDSLGDLGYFD
TH_3407|M.thermoresistible__bu GNECPPVVVGEIYMRPSPGSGPTYRYVG---ATAKSRDGWDSLGDLGYFD
Mflv_0419|M.gilvum_PYR-GCK GNECPPGVPGEIYMRPAPGARPTYRYIG---STAKSRDGWDSLGDLGYFD
Mvan_0252|M.vanbaalenii_PYR-1 GDECPPGVAGEIYMRSAPGGPPTYRYVG---STAKSRDGWESLGDLGYFD
MAB_2316|M.abscessus_ATCC_1997 GNPLPAGEVGEIFMRPWEGMPTPYKYLG---AEIKRFGTWESIGDLGWLD
Mb3116|M.bovis_AF2122/97 GVIREHGE-GEVVIKSDILLKEYWNRPE--ATRDAFDNGWFRTGDIGEID
Rv3089|M.tuberculosis_H37Rv GVIREHGE-GEVVIKSDILLKEYWNRPE--ATRDAFDNGWFRTGDIGEID
MLBr_02546|M.leprae_Br4923 GKEVPRGQVGRIFVGNAFPFEGYTGGGG-----KQIIDGLLSSGDVGYFD
* : : **:* :*
MMAR_3983|M.marinum_M EDGYLYIVDRRVDMIVTGGANVFPAEVESALAGHPGIADVVVIGIADARW
MUL_3844|M.ulcerans_Agy99 EDGYLYIVDRRVDMIITGGANVFPAEVESALAGHPGIADVVVIGIADARW
MAV_1627|M.avium_104 EDGYLYIVDRRVDMIISGGANVFPAEVESALAGHPAIADVVVIGLADPQW
MSMEG_0318|M.smegmatis_MC2_155 TDGFLYLNDRRVDMFTVGGRNVYPAEIEAALSAHPEVLSCLAVGIPHTDL
TH_3407|M.thermoresistible__bu EDGFLYLSDRRVDMFTVGGRNVYPAEVESALAEHPEVLSALVVGIPDDDL
Mflv_0419|M.gilvum_PYR-GCK EDGFLYLNDRRVDMFTVGGRNVYPAEIESALAEHPGVLSSLVVGLPDDDL
Mvan_0252|M.vanbaalenii_PYR-1 EDGFLYLNDRRVDMFTVGGRNVYPAEIESALAEHPRVLSSLAMGLPDDDL
MAB_2316|M.abscessus_ATCC_1997 DDGYLYMSDRRTDLIVTGGANVFPAEVESVMNGYPGVIDSVVVGLPDDDL
Mb3116|M.bovis_AF2122/97 DEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKW
Rv3089|M.tuberculosis_H37Rv DEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKW
MLBr_02546|M.leprae_Br4923 EHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEW
.. **: .* ::: ** **:***:* : * : . .:*: .
MMAR_3983|M.marinum_M GRRVHAVVQVA--APLTEQQVIEYAKNRLAPYKVPKTVEFVDRIPRTAAT
MUL_3844|M.ulcerans_Agy99 GRRVHAVVQVA--APLTEQQVIEYAKNRLAPYKVPKTVEFVDQIPRTAAT
MAV_1627|M.avium_104 GRRVHAVVQRADGASLTEQQVIDYAKGRLAPYKAPKTVEFVDAIPRTAAT
MSMEG_0318|M.smegmatis_MC2_155 GQVPHALVQTAPGSTLDAAGLRDFLRDAVSSYKVPHTIEFVDEPLRDDAG
TH_3407|M.thermoresistible__bu GQVPYAIVHTADGSDLDEAAVIGFLRERIAGYKVPRHVEFSATPVRDDAG
Mflv_0419|M.gilvum_PYR-GCK GHVPHAIVQAD----LSEADVLAFLGERIASYKLPRTVEFTDRPLRDDAG
Mvan_0252|M.vanbaalenii_PYR-1 GQVPHAIVQAHG---LDEAEVIAFLAERIASHKLPRSVEFTDRPLRDDAG
MAB_2316|M.abscessus_ATCC_1997 GQSVHAVVHAEPN--VTEDQLRDYLLDQIVRYKVPRTIEFVADPLREDSG
Mb3116|M.bovis_AF2122/97 GEIAAAIVVADQ-NEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTG
Rv3089|M.tuberculosis_H37Rv GEIAAAIVVADQ-NEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTG
MLBr_02546|M.leprae_Br4923 GARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREVIFLEELPRNPTG
* *.* : : : : :* *: : * * :
MMAR_3983|M.marinum_M KVNRSAM---IAARGG------
MUL_3844|M.ulcerans_Agy99 KVNRSAM---IAARGG------
MAV_1627|M.avium_104 KVNRSAM---IAARGG------
MSMEG_0318|M.smegmatis_MC2_155 KARRTAVRDAVIARLGRAPAAR
TH_3407|M.thermoresistible__bu KARRSAVRDEVIARSASRRS--
Mflv_0419|M.gilvum_PYR-GCK KARRSAVRDEVLARRA------
Mvan_0252|M.vanbaalenii_PYR-1 KARRSAVRDEVIARRSS-----
MAB_2316|M.abscessus_ATCC_1997 KVRRSLIREQATARRAAAG---
Mb3116|M.bovis_AF2122/97 KILKTVLREQYSATVPK-----
Rv3089|M.tuberculosis_H37Rv KILKTVLREQYSATVPK-----
MLBr_02546|M.leprae_Br4923 KVLKRELRDFEVH---------
* : :