For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3085 | - | - | 100% (509) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3338 | - | e-163 | 57.43% (491) | PUTATIVE acyl-CoA synthase |
| M. thermoresistible (build 8) | TH_4613 | - | e-137 | 51.57% (508) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0220 | fadD4 | 1e-125 | 48.50% (501) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0449 | - | 1e-131 | 48.74% (517) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0214 | fadD4 | 1e-125 | 48.50% (501) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-55 | 30.44% (519) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3435 | - | 0.0 | 63.41% (511) | acyl-CoA synthetase |
| M. marinum M | MMAR_0452 | fadD4 | 1e-123 | 47.71% (503) | fatty-acid-CoA ligase FadD4 |
| M. avium 104 | MAV_5098 | - | 1e-160 | 59.09% (484) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0257 | - | 1e-128 | 49.20% (500) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 2e-55 | 31.32% (514) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0015 | - | 1e-179 | 59.84% (508) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0220|M.bovis_AF2122/97 --------------------------MPRGELYKRFRLVMGGIAPCGSGR
Rv0214|M.tuberculosis_H37Rv --------------------------MPRGELYKRFRLVMGGIAPCGSGR
MMAR_0452|M.marinum_M --------------------------------------------------
MSMEG_0257|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0449|M.gilvum_PYR-GCK --------------------------------------------------
TH_3085|M.thermoresistible__bu --------------------------------------------------
MAB_3435|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_5098|M.avium_104 --------------------------------------------------
Mvan_0015|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
Mb0220|M.bovis_AF2122/97 RAATYPRRMQIRPYIAA--DKPAVILYPSGTVISFDELEARANRLAHWFR
Rv0214|M.tuberculosis_H37Rv RAATYPRRMQIRPYIGA--DKPAVILYPSGTVISFDELEARANRLAHWFR
MMAR_0452|M.marinum_M --------MQIRQHVGA--DKPAVILHPSGTVVSFDELEARANRLAHRFR
MSMEG_0257|M.smegmatis_MC2_155 --------MQIREHVGA--NKPAIILYPSGTVVTFDELEARANRLAHHFR
Mflv_0449|M.gilvum_PYR-GCK --------MQIRDTAVATPDKPAVIMYPAGTVVTFGELEARANRLAHLFR
TH_3085|M.thermoresistible__bu --------MYPGTHALKTPDKPAIIMPETGETVTYGQLDTRSLRFARHLH
MAB_3435|M.abscessus_ATCC_1997 --------MYPGAHAAQFPDKPAVVMAGSGATLTYGELDRQSRRLARHWY
MAV_5098|M.avium_104 --------------------------------MTYRELDENSARLASALH
Mvan_0015|M.vanbaalenii_PYR-1 --------MYPGTHARTAPERAAVVVAETGETLSYRRLDEQSAALARVLH
MLBr_02546|M.leprae_Br4923 MRKWGDLAMLPAMPARRSPHRAALIDEEG--TLTYKELDRAAHALANGLI
MUL_1191|M.ulcerans_Agy99 IAKWGEFGMLPSFNARRHPHRAACIDEEG--EFTYQQLDEAGHAVANALL
.:: .*: . .*
Mb0220|M.bovis_AF2122/97 QAGLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIV
Rv0214|M.tuberculosis_H37Rv QAGLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIV
MMAR_0452|M.marinum_M RAGLREGDAVAILMENNEHIHAVMWAARRSGLYYVPINTHLTAAEAAYII
MSMEG_0257|M.smegmatis_MC2_155 NQGLQEGDVVAILMENNSHIHTVMWAARRSGLYYVPISTHLTAAEAAYIV
Mflv_0449|M.gilvum_PYR-GCK DAGLVEGDAVALLMENNEHFHAVMWAARRAGLYYVPINTHLTAAEVAYIV
TH_3085|M.thermoresistible__bu DDGVRPGDHIAVLSDNQARALEIYWAAIRSGLYVTFLNSQLSADEVAYIV
MAB_3435|M.abscessus_ATCC_1997 DSGLRKGDHVALLSDNVPEVFVVYWAALRSGLYITSVNHHLAPAEVSYIV
MAV_5098|M.avium_104 SVGLRKGDVIAMLSDNAVEAFEIYWAAIRSGLYITAINWHLAAEEAAYIL
Mvan_0015|M.vanbaalenii_PYR-1 DAGLRPGDVVVLLSDNAPEALVVLWAAQRSGLYVTAINHHLTPAEAGYIV
MLBr_02546|M.leprae_Br4923 AKGVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVS
MUL_1191|M.ulcerans_Agy99 AKGVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFSGPQIKEVS
*: .* :.:* * :.. * * :. .:: : :
Mb0220|M.bovis_AF2122/97 DNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAG----------GGL
Rv0214|M.tuberculosis_H37Rv DNSGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAG----------GGL
MMAR_0452|M.marinum_M ENSGAKAIVGSAALRDTCAGLGEHLRAGPPELLILAGPE--------GCL
MSMEG_0257|M.smegmatis_MC2_155 DNSGAKAIVGSAKMRDVLAGLGDELPNGLPDTLLIAD----------GDL
Mflv_0449|M.gilvum_PYR-GCK DNSGAKAIVGSAKLADTLAGLEAELPNGLPQLLLVAGAELSATSASGGDV
TH_3085|M.thermoresistible__bu NDCEAETFIVAERYAETACAAVKQTP-RVRRRIALG------------LV
MAB_3435|M.abscessus_ATCC_1997 NDSGSSALVVAAGVREQAEAILDDTP-AVTLRLAFGG-----------DV
MAV_5098|M.avium_104 RDSGARVLIASAGVAELAEQLTGLVP-DLKHRYAFGG-----------AV
Mvan_0015|M.vanbaalenii_PYR-1 CDSGARALVASAALRELADGVVAEAG-GPEVRIAFGG-----------RI
MLBr_02546|M.leprae_Br4923 EREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEE--------PPG
MUL_1191|M.ulcerans_Agy99 EREGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEE--------DSG
: ::
Mb0220|M.bovis_AF2122/97 VGWMTYPECVADQPDTPIEDE-REGDLLQYSSGTTGRPKGIKRELPHVSP
Rv0214|M.tuberculosis_H37Rv VGWMTYPECVADQPDTPIEDE-REGDLLQYSSGTTGRPKGIKRELPHVSP
MMAR_0452|M.marinum_M TGWEPYPQCVADQPDTAIDDE-LEGDLLQYSSGTTGRPKGIKRELLHVAP
MSMEG_0257|M.smegmatis_MC2_155 DGWLRYPEAVADLPDTPIDDE-LDGDLLQYSSGTTGRPKGIKRELPHVHP
Mflv_0449|M.gilvum_PYR-GCK DGWQRYPECVADKLETPIADE-IDGDLLQYSSGTTGRPKGIKRELPHLPP
TH_3085|M.thermoresistible__bu DGFSDYEALLAAASSEPLPAQ-PCGVDMLYSSGTTGFPKGIKRPLPDRAV
MAB_3435|M.abscessus_ATCC_1997 RGYDSYEDALDGASDEPLPAQ-PAGSDMLYSSGTTGRPKGIKVPLTDRQV
MAV_5098|M.avium_104 AGYAPYRELLAPA--PRLKEQ-PRGSEMLYSSGTTGRPKGIKPRLLPIQV
Mvan_0015|M.vanbaalenii_PYR-1 DGFADYESTLAAAG-PPLAEQ-PCGAVMLYSSGTTGFPKGIRPDLPERSV
MLBr_02546|M.leprae_Br4923 STDETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTP--AS
MUL_1191|M.ulcerans_Agy99 STDETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTP--PT
: . : :***** *** .
Mb0220|M.bovis_AF2122/97 DAAPGMMPALLD--FWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVV
Rv0214|M.tuberculosis_H37Rv DAAPGMMPALLD--FWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVV
MMAR_0452|M.marinum_M DAAPGMMSALVG--YWMDADSIYLSPAPLYHTAPSVWSMSAQAGGITTVV
MSMEG_0257|M.smegmatis_MC2_155 SENPGMMAALIS--FWMTPDSVYLSPAPLYHTAPSVWSMQVQAAGHTTVV
Mflv_0449|M.gilvum_PYR-GCK AEVPGMMAMLVE--FWMHPDAVYLSPAPLYHTAPSVWSMQVQAGGITTVV
TH_3085|M.thermoresistible__bu DEPGDPVTALFAPVMGLDADSVYLSPAPVYHAAPLRFMAMAHQIGATVVM
MAB_3435|M.abscessus_ATCC_1997 DEP-NPFAMLFAHLYGFNAETVYLSPAPIYHAAPLRFCGFVQSMGGTAVV
MAV_5098|M.avium_104 DEPGDPLVGLLAHAFKICADDVYLSPAPIYHTAPLKWCAGVQALGGTVVL
Mvan_0015|M.vanbaalenii_PYR-1 DQPGDPVVAIAGGLFGITSSDVYFSSAPIYHAAPLRWCGMVHALGGTVVL
MLBr_02546|M.leprae_Br4923 LAPLGGILSKVP----FRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVL
MUL_1191|M.ulcerans_Agy99 LAPVGGILSHVP----FKANEVTSLPAPMFHALGYLHATIAMFLGSTLVL
. . : . : .**::*: . * * *:
Mb0220|M.bovis_AF2122/97 MEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRV
Rv0214|M.tuberculosis_H37Rv MEKFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRV
MMAR_0452|M.marinum_M LEKFDPEGALEAIQRHRVTHAQFVPAMFTRMLKLPESIRNSYDVSSLKRV
MSMEG_0257|M.smegmatis_MC2_155 MEKFDAEGCLEAIQKHRVTHGQFVPAMFTRMLKLPESVRNSYDVSSLKRV
Mflv_0449|M.gilvum_PYR-GCK MEKFDAEGALDAIQKYKVTHGQFVPVMFARMLKLPEDVRKSYDVSSLQRV
TH_3085|M.thermoresistible__bu MRKFDAEEALRAIDRYRVTHSQWVPTMFIRMLKLDPQVRESYDVSTLRCA
MAB_3435|M.abscessus_ATCC_1997 MERFEAEEALAAIEKYRITHSQWVPTMFVRMLKLPKEIRDRYDVSSLKVA
MAV_5098|M.avium_104 MERFDAEKALAAIEKYKTTVMQVVPTMFVRMLQLSEAVRAGYDVSSLRLA
Mvan_0015|M.vanbaalenii_PYR-1 AKRFDAADTLRYIEKFRITATQMVPTMFVRMLKLNDEVRSRYDLSSLRGV
MLBr_02546|M.leprae_Br4923 RRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVV
MUL_1191|M.ulcerans_Agy99 RRKFKPQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIV
.:*.. * *::.: * **.*: *:*. : *:*:*: .
Mb0220|M.bovis_AF2122/97 IHAAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSV
Rv0214|M.tuberculosis_H37Rv IHAAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSV
MMAR_0452|M.marinum_M MHAAAPCPVEIKKQMMDWWGPIIDEYYASSEAIGSTLITAEDWLEHPGSV
MSMEG_0257|M.smegmatis_MC2_155 MHAAAPCPVDIKKQMIDWWGPIVDEYYASSEAIGATLITAEEWLKHPGSV
Mflv_0449|M.gilvum_PYR-GCK MHAAAPCPVEIKKQMIDWWGPIVDEYYASSEAHGSTLITADQWLERPGSV
TH_3085|M.thermoresistible__bu VHAAAPCPVDVKKAMIDWWGPILLEYYSSTEMNGVTLIDSEEWLQRPGSV
MAB_3435|M.abscessus_ATCC_1997 VHAAAPCPVEVKQSMIDWWGPILYEYYSSTEGNGVTFIDCATWLKRPGSV
MAV_5098|M.avium_104 VHAAAPCAPDVKDAMIDWWGPILVEYYGATEQHGTTVITTAEWQKKRGSV
Mvan_0015|M.vanbaalenii_PYR-1 IHAAAPCPVDVKQAMIDWLGPIIWEYYSSTEVHGMTVIDTGQWLSHQGSV
MLBr_02546|M.leprae_Br4923 FVSGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATV
MUL_1191|M.ulcerans_Agy99 FVSGSQLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATV
. :.: :: :. **:: : *.::* *. . .:*
Mb0220|M.bovis_AF2122/97 GKPIQGG-VHIVGADGSELPPNQPGEIYFEGG-YPFEYLNDPAKTAASRN
Rv0214|M.tuberculosis_H37Rv GKPIQGG-VHIVGADGSELPPNQPGEIYFEGG-YPFEYLNDPAKTAASRN
MMAR_0452|M.marinum_M GKPMQGG-VHILGADGVELPPGQAGEIYFEGG-YSFEYLNDPSKTAASRD
MSMEG_0257|M.smegmatis_MC2_155 GKPLTGI-VHVLDEDGNELPPGQAGEIFFEGG-QDFEYLNDAEKTASSRD
Mflv_0449|M.gilvum_PYR-GCK GKPLTGV-VHIVGEDGNELPAGQAGEIYFEGG-YDFEYLNDPDKTASSRH
TH_3085|M.thermoresistible__bu GRPRLGI-VRICDDDGVEVPVGQTGTVYFERDEAPFEYHNDPERTAETRH
MAB_3435|M.abscessus_ATCC_1997 GSAALGV-LHICDETGAELPAGEAGLVYFEREELPFSYHNDDEKTRSACH
MAV_5098|M.avium_104 GRAALGV-LHICDDDGRELSAGEVGTVYFERDVAPFEYHNDPEKTASSRH
Mvan_0015|M.vanbaalenii_PYR-1 GRSVLGT-LHICDDDGHDLPAGEVGTVYFERDALPFSYHNAPEKTAEAQH
MLBr_02546|M.leprae_Br4923 GPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDG-
MUL_1191|M.ulcerans_Agy99 GPVVKGVKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGGGHKQIIDG-
* * ::: . * ::. .: * ::. * . :
Mb0220|M.bovis_AF2122/97 KHG--WVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAH
Rv0214|M.tuberculosis_H37Rv KHG--WVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAH
MMAR_0452|M.marinum_M KHG--WVTVGDVGYLDDQGYLFLTDRRHHMIISGGVNIYPQEAENILVTH
MSMEG_0257|M.smegmatis_MC2_155 ARG--WKTVGDIGYLDEEGYLYLTDRRHHMIISGGVNIYPQEAENMLVTH
Mflv_0449|M.gilvum_PYR-GCK PQG--WKTVGDIGYVDEEGFLFLTDRRHHMIISGGVNIYPQEAENLLVTH
TH_3085|M.thermoresistible__bu PDHPTWTTTGDIGYVDEDGYLYLTDRKSFTIISGGVNIYPQEIENALALH
MAB_3435|M.abscessus_ATCC_1997 PAHDTWTTTGDIGYVDEDGFLYLTDRKAFMIISGGVNIYPQEIENALALH
MAV_5098|M.avium_104 PVFDNWSTVGDIGYVDEDGYLFLTDRKAFVIISGGVNIYPQEVENVLTLH
Mvan_0015|M.vanbaalenii_PYR-1 PAHPFWTTVGDLGYVDDEGYLYLADRKAFMIISGGVNIYPQEVENALTLH
MLBr_02546|M.leprae_Br4923 -----LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGH
MUL_1191|M.ulcerans_Agy99 -----LMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGH
: **:**.*:.. *:::.* *:*** *::* * * : *
Mb0220|M.bovis_AF2122/97 PKVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSH
Rv0214|M.tuberculosis_H37Rv PKVLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSH
MMAR_0452|M.marinum_M PKVMDAAVFGVPDDEMGQRVMAVVQTVDPADATSQFGDELMEWLRDRLSH
MSMEG_0257|M.smegmatis_MC2_155 PKVMDAAVFGVPDDEMGQSVKGVVQTVDPADATPEFGEELLAWLRDRLAH
Mflv_0449|M.gilvum_PYR-GCK PKVMDAAVFGIPDEEMGQRVKAVVQLVDQADATEEFADELIGWLRDRLAH
TH_3085|M.thermoresistible__bu PGVYDVAVIGVPDPEMGESVLAVVHPSEQ-AGP-DLAGELDRFLRERIAH
MAB_3435|M.abscessus_ATCC_1997 PAVLDVAVIGVPDAEMGESVKAVVQPADSSAAPRELAAELTDFLRERIAR
MAV_5098|M.avium_104 PKVFDVAVIGVPDPEMGEQVKAVIQLRSGTTPSDQLADEIIAYVRERIAH
Mvan_0015|M.vanbaalenii_PYR-1 PAVHDVAVIGVPDPEMGEQVKAVVHLTAGVDPSEELARELIDYTRARIAH
MLBr_02546|M.leprae_Br4923 PEVVEATAIGVDDKEWGARLRAFVVKKQDATID---EDAIKAYVRDHLAR
MUL_1191|M.ulcerans_Agy99 PDVVEATALGVDDKEWGARLRAFVVKKPDTDLD---EETVKHYVRDHLAR
* * :.:.:*: * * * : . : : : * ::::
Mb0220|M.bovis_AF2122/97 FKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV---
Rv0214|M.tuberculosis_H37Rv FKCPRSIAFEPQLPRTDTGKLYKSGLVEKYSV---
MMAR_0452|M.marinum_M FKCPRSVAFEAQLPRTDTGKLYKNGLIEKYSG---
MSMEG_0257|M.smegmatis_MC2_155 YKCPRSISFELQLPRTDTGKLYKQELIAKYS----
Mflv_0449|M.gilvum_PYR-GCK YKCPRSLSFEEQLPRTDTGKLYKQELIKKYS----
TH_3085|M.thermoresistible__bu YKLPRRYEFSTDLPRTPTGKLVKGRLRERYSSG--
MAB_3435|M.abscessus_ATCC_1997 YKVPRSFDFTDTLPRTPTGKLAKGLLRQKYWEGAQ
MAV_5098|M.avium_104 YKAPRSVDFVDDLPRTATGKLMKRTLKARYMEATA
Mvan_0015|M.vanbaalenii_PYR-1 YKAPRSVDFVDDLPRTPTGKLVKGKLRERYLVDV-
MLBr_02546|M.leprae_Br4923 YKVPREVIFLEELPRNPTGKVLKRELRDFEVH---
MUL_1191|M.ulcerans_Agy99 YKVPREVIFLEELPRNPTGKILKRELREMEIE---
:* ** * ***. ***: * *