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VAVMTDAAVGEPFVRILANLADAEPDAPAVTCGTDSVTRAELERRATALAHAYQRLGVRQGDLVTIGLPN SVEFFAAQIAVWKLGATPQPVSWRLPLAERRAIVELADSTLVVGVDPADHPDRVCVSAGFEPGAEDYLAG PVPEVVSPAWKAPTSGGSTGRPKIIVAPTPAVITGTAAGEIMGMQHADAQLVAGPLYHNAPLMFSSYGLL LGHHLVVQPKFDALEALELIGTHKVTWLQVVPTMMSRMLRELRQHPGRFDLSTIRVLWHMAAPCPVWLKQ AWIDLLGPEVIWELYAGTEAIGGTIITGQEWLAHRGSVGKPALGELAILDENGNPLPAGEVGEIFMRPWE GMPTPYKYLGAEIKRFGTWESIGDLGWLDDDGYLYMSDRRTDLIVTGGANVFPAEVESVMNGYPGVIDSV VVGLPDDDLGQSVHAVVHAEPNVTEDQLRDYLLDQIVRYKVPRTIEFVADPLREDSGKVRRSLIREQATA RRAAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2316 | - | - | 100% (496) | acid-CoA ligase |
| M. abscessus ATCC 19977 | MAB_3435 | - | 3e-69 | 34.78% (506) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4340c | - | 9e-49 | 30.52% (498) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0220 | fadD4 | 2e-68 | 34.50% (484) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0419 | - | 1e-124 | 47.06% (493) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0214 | fadD4 | 2e-68 | 34.50% (484) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-47 | 30.32% (498) | acyl-CoA synthetase |
| M. marinum M | MMAR_3983 | - | 9e-76 | 37.83% (497) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_4961 | - | 2e-74 | 36.53% (490) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0318 | - | 1e-128 | 47.81% (502) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3407 | - | 1e-125 | 47.84% (485) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3844 | - | 2e-77 | 38.29% (491) | fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_0252 | - | 1e-125 | 47.24% (489) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0220|M.bovis_AF2122/97 ----MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIAADKPAV
Rv0214|M.tuberculosis_H37Rv ----MPRGELYKRFRLVMGGIAPCGSGRRAATYPRRMQIRPYIGADKPAV
MAV_4961|M.avium_104 ------------------------------------MQIREYLGAGKPAV
Mflv_0419|M.gilvum_PYR-GCK -----------------MTEGQASAVDAPVPPISTQVSALAARSPDAAAI
Mvan_0252|M.vanbaalenii_PYR-1 -----------------MTA-------APVPPIGTQVSALAAQAPDAPAA
MSMEG_0318|M.smegmatis_MC2_155 -----------------MTDK-----GFDVPPIGTQVAHLAAADPDRPAV
TH_3407|M.thermoresistible__bu -----------------MADTT-DVPGTPVPPIGTRFAALAQTDPTAPAV
MAB_2316|M.abscessus_ATCC_1997 -----------------MAVMT---DAAVGEPFVRILANLADAEPDAPAV
MMAR_3983|M.marinum_M ------------MSTQPMGPGATTNPLADGVPFGTRLEELAEQRRDETAV
MUL_3844|M.ulcerans_Agy99 ------------MSTQPMGPGTTTNPLADGVPFGTRLEELAEQRRDETAV
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
*
Mb0220|M.bovis_AF2122/97 ILYPSG-------------TVISFDELEARANRLAHWFRQAGLREDDVVA
Rv0214|M.tuberculosis_H37Rv ILYPSG-------------TVISFDELEARANRLAHWFRQAGLREDDVVA
MAV_4961|M.avium_104 ILYPSG-------------TVVTFDDLEARANRLAHRFRKAGLREGDTVA
Mflv_0419|M.gilvum_PYR-GCK TCAG---------------RTVTRAELDATSNRIARGFASRGVGIGDYVT
Mvan_0252|M.vanbaalenii_PYR-1 TCDG---------------VTVTRRELDATSNRLARAFASLGVGVGDYVT
MSMEG_0318|M.smegmatis_MC2_155 SCQG---------------RTLSRGELDRSTNRLARAYAELGVRQGDYVT
TH_3407|M.thermoresistible__bu SCAG---------------VTLTRRELDASTNRLARAFAELGVGQGDYVT
MAB_2316|M.abscessus_ATCC_1997 TCGT---------------DSVTRAELERRATALAHAYQRLGVRQGDLVT
MMAR_3983|M.marinum_M TIVAPDGST----------QSMTFGELDCLANQWGRTLAAHGAQTGSLVA
MUL_3844|M.ulcerans_Agy99 TIVAPEGST----------QSMTFGELDRLANQWGRTLAAHGAQTGSLVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
:: :*: : .. * .. ::
Mb0220|M.bovis_AF2122/97 ILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGS
Rv0214|M.tuberculosis_H37Rv ILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDNSGAKAIVGS
MAV_4961|M.avium_104 ILMENNEHIHVVMWAARRSGLYYVPINTHLTAAEAAYIVDNSSARAIVGS
Mflv_0419|M.gilvum_PYR-GCK IVLPNSIDWAYAVLACWKLGAVPQPLSARMPDAELGALLQLRRPALLVGR
Mvan_0252|M.vanbaalenii_PYR-1 IVLPNSLDWAYSVLACWKLGAVPQPLSARLPDAELAALLELRRPALLVGR
MSMEG_0318|M.smegmatis_MC2_155 ICLHNSIEWVQATLATWKLGAVPQPLSPRMPDAEFEAILGLKRRALVVGR
TH_3407|M.thermoresistible__bu ISLFNSIEWLQATLAVWKLGAIPQPLSPRLPDPEFAELLALRRRALLVGR
MAB_2316|M.abscessus_ATCC_1997 IGLPNSVEFFAAQIAVWKLGATPQPVSWRLPLAERRAIVELADSTLVVGV
MMAR_3983|M.marinum_M LAIPNSQHLVLATLGCWKIGAVPIPMHWDLPEWERDRVRAVIDPAVIVDE
MUL_3844|M.ulcerans_Agy99 LAIPNSQHLVLATLGCWKIGAVPIPMHWDLPEWERDRVRAVIDPAVIVDE
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * . : * : :. : : ::
Mb0220|M.bovis_AF2122/97 AALRETCHGLAEHLPGGLPDLLMLAGGGLVG--WMTYPECVADQPDTPIE
Rv0214|M.tuberculosis_H37Rv AALRETCHGLAEHLPGGLPDLLMLAGGGLVG--WMTYPECVADQPDTPIE
MAV_4961|M.avium_104 AALRDTCARLGEHLPGGLPDLLLMADGDLDG--WERYPECVAGEPDTPID
Mflv_0419|M.gilvum_PYR-GCK TDPTGLTAGTTTDLAR--EFADESD---------AALPEAVSPVWKA---
Mvan_0252|M.vanbaalenii_PYR-1 PDPTGVTPDVAVELAA--EFPD------------SPLPEAVSPVWKS---
MSMEG_0318|M.smegmatis_MC2_155 -DPGGDISWVPGDFEPGPGLAD------------DPLPEAVSPTWKS---
TH_3407|M.thermoresistible__bu PAPDGSIPHVPAGFTPDPALSD------------GPLPEAVSPVLKS---
MAB_2316|M.abscessus_ATCC_1997 -DPADHPDRVCVSAGFEPGAEDYLA---------GPVPEVVSPAWKA---
MMAR_3983|M.marinum_M HNRWRLQAHAAGESRD-------------------PLPAAVSPTANG---
MUL_3844|M.ulcerans_Agy99 HNRWRLQAHAAGESRD-------------------PLPTAVSPTANG---
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAP
. :: .
Mb0220|M.bovis_AF2122/97 DERE-GDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADS
Rv0214|M.tuberculosis_H37Rv DERE-GDLLQYSSGTTGRPKGIKRELPHVSPDAAPGMMPALLDFWMDADS
MAV_4961|M.avium_104 DELE-GDLLQYSSGTTGRPKGIKRELPHVHPAEAPGMMSALVGFWMTPES
Mflv_0419|M.gilvum_PYR-GCK ---------MASGGSTGRPKLIEAGNDSRVP-PAIGYPLG-----AQEGD
Mvan_0252|M.vanbaalenii_PYR-1 ---------MASGGSTGRPKLIEAGNDSRVP-PAIGYPLG-----AQEGD
MSMEG_0318|M.smegmatis_MC2_155 ---------IASGGSTGRPKLIEAGGDGRVP-ALIGAPLG-----AEPDD
TH_3407|M.thermoresistible__bu ---------MASGGSTGRPKLIESGGDARVP-PVIGTPLG-----AEPGD
MAB_2316|M.abscessus_ATCC_1997 ---------PTSGGSTGRPKIIVAPTPAVITGTAAGEIMG-----MQHAD
MMAR_3983|M.marinum_M ---------ICSSGSTGVPKVILNLAPSLWT-PQHGEPFLSAWTPVAQPQ
MUL_3844|M.ulcerans_Agy99 ---------ICSSGSTGVPKVILNLAPSLWT-PEHGEPFLSAWTPVAQPQ
MLBr_02546|M.leprae_Br4923 KVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVP----FRAHE
:.*:** ** . .
Mb0220|M.bovis_AF2122/97 VYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHA
Rv0214|M.tuberculosis_H37Rv VYLSPAPMYHTAPSVWTMSALAAGVTTVVMEKFDAEGALDAIQRYRVTHA
MAV_4961|M.avium_104 IYLSPAPLYHTAPSVWSMSAQAGGITTVVMEKFDAEGCLDAIQRHRVTHG
Mflv_0419|M.gilvum_PYR-GCK VNLVSVPLSHNTGFTTFAIGLLQGHHLVVMPRFEPREFLRLITEHRVTFL
Mvan_0252|M.vanbaalenii_PYR-1 VTLVSVPLSHNTGFTTFAVGLLQGHHLVVMPRFEPHEFLRLVTEHRVTFL
MSMEG_0318|M.smegmatis_MC2_155 VTLMSVPMSHNTGFTTFAIALLMGQHLVLMPRFEPAEFLRLVTSHRVTFL
TH_3407|M.thermoresistible__bu VNLISVPLSHNTGFTTAVIGLVQGHHLVLMPRFDAAEFLRLVTDFRVTWL
MAB_2316|M.abscessus_ATCC_1997 AQLVAGPLYHNAPLMFSSYGLLLGHHLVVQPKFDALEALELIGTHKVTWL
MMAR_3983|M.marinum_M TIMVPAPMYHTNGFATFLM-LLGGDHLVVLERFDAALVVDVIERFRVTNF
MUL_3844|M.ulcerans_Agy99 TIMVPAPMYHTNGFATFMM-LLGGDHLVVLEKFDAALVVDVIERFRVTNF
MLBr_02546|M.leprae_Br4923 VTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVLEDIEKHQATAM
: . *: * * *: :*.. : : .:.*
Mb0220|M.bovis_AF2122/97 QFVPAMFVRMLKLPE----AVRNSYDMSSLRRVIHAAAPCPVQIKEQMIH
Rv0214|M.tuberculosis_H37Rv QFVPAMFVRMLKLPE----AVRNSYDMSSLRRVIHAAAPCPVQIKEQMIH
MAV_4961|M.avium_104 QFVPAMFTRMLKLPE----AVRHSYDLSSLQRVMHAAAPCPVEIKKQMID
Mflv_0419|M.gilvum_PYR-GCK TTVPTIMQRLLPVYR----ADPDAYDLSSIRRFWHVASACPPAVKRAWID
Mvan_0252|M.vanbaalenii_PYR-1 TTVPTIMQRLLPVYR----ADPDAYDLSSIRRFWHLAAPCPPAVKHAWIE
MSMEG_0318|M.smegmatis_MC2_155 TTVPTIMQRLLPVYR----AEPDAYDLTSIRRFWHVGAPCPPAVKQAWID
TH_3407|M.thermoresistible__bu TTVPTIMQRLLPVYRAAAAADPGRYDLSSLRRFWHVGAPCPPAVKEAWIE
MAB_2316|M.abscessus_ATCC_1997 QVVPTMMSRMLRELR----QHPGRFDLSTIRVLWHMAAPCPVWLKQAWID
MMAR_3983|M.marinum_M TATPTMLARIAAIPG------IRQRDLSSIVFILQGAAVMPPSLLHTWFE
MUL_3844|M.ulcerans_Agy99 TATPTMLARIAAIPG------IRQRDLSSIVFILQGAAVMPPSLLHTWFE
MLBr_02546|M.leprae_Br4923 VVVPVMLSRILDTLEN----LETKSDLSSLRVVFVSGSQLGAELATRALE
.*.:: *: *:::: . .: : :.
Mb0220|M.bovis_AF2122/97 WWGP-IIDEYYASSEASGSTLITAEDWLTHPGSVG-KPIQGGVHIVGADG
Rv0214|M.tuberculosis_H37Rv WWGP-IIDEYYASSEASGSTLITAEDWLTHPGSVG-KPIQGGVHIVGADG
MAV_4961|M.avium_104 WWGP-IIDEYYASSEAIGSTLISAEEWLAHPGSVG-KPMACEIHILDENG
Mflv_0419|M.gilvum_PYR-GCK IVGPDALWELYGGTELQALTFISGTQWLTHPGSVG-VVVAGEMKVLDDDG
Mvan_0252|M.vanbaalenii_PYR-1 LLGPDAVWELYGGTELQALTFISGDQWLTHPGSVG-VVVAGEMKVLDDDG
MSMEG_0318|M.smegmatis_MC2_155 LLGPQVVWELYGGTELQALTFISGEQWLTHPGSVG-VVVAGEMKVLDDDG
TH_3407|M.thermoresistible__bu ILGPQVLWELYGGTELQALTFISGEQWLSHRGSVG-VVVSGEMKVLDDDG
MAB_2316|M.abscessus_ATCC_1997 LLGPEVIWELYAGTEAIGGTIITGQEWLAHRGSVG-KPALGELAILDENG
MMAR_3983|M.marinum_M LLGPEKIVTAYGMTENLGLTALRGDEWVSHPGSVGRGFRETEIQILDSQQ
MUL_3844|M.ulcerans_Agy99 LLGPEKIVTAYGMTENLGLTALRGDEWVSHPGSVGRGFRETEIQILDSQQ
MLBr_02546|M.leprae_Br4923 ELGP-VIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKGVKVKILDDSG
** : *. :* * : : .:** : ::. .
Mb0220|M.bovis_AF2122/97 SELPPNQPGEIYFEGG--YPFEYLNDPAKTAASRNKHGWVTVGDVGYLDD
Rv0214|M.tuberculosis_H37Rv SELPPNQPGEIYFEGG--YPFEYLNDPAKTAASRNKHGWVTVGDVGYLDD
MAV_4961|M.avium_104 NELPPGQAGEIYFSGG--YSFEYLNDEAKTAASRDKHGWVTVGDVGYVDE
Mflv_0419|M.gilvum_PYR-GCK NECPPGVPGEIYMRPAPGARPTYRYIG---STAKSRDGWDSLGDLGYFDE
Mvan_0252|M.vanbaalenii_PYR-1 DECPPGVAGEIYMRSAPGGPPTYRYVG---STAKSRDGWESLGDLGYFDE
MSMEG_0318|M.smegmatis_MC2_155 NECPPGVTGEVYMRPSPGSTPTYRYVG---TTAKSRDGWDSLGDLGYFDT
TH_3407|M.thermoresistible__bu NECPPVVVGEIYMRPSPGSGPTYRYVG---ATAKSRDGWDSLGDLGYFDE
MAB_2316|M.abscessus_ATCC_1997 NPLPAGEVGEIFMRPWEGMPTPYKYLG---AEIKRFGTWESIGDLGWLDD
MMAR_3983|M.marinum_M QPVGPGEHGDVYLRAP--MSAGYRYLGGAPPLPSTGEGYRCAGDIGYLDE
MUL_3844|M.ulcerans_Agy99 QPVGPGEHGDVYLRAP--MSAGYRYLGGAPPLPSTGEGYRCAGDIGYLDE
MLBr_02546|M.leprae_Br4923 KEVPRGQVGRIFVGNAFPFEGYTGGGG-----KQIIDGLLSSGDVGYFDE
. * ::. **:*:.*
Mb0220|M.bovis_AF2122/97 DGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMG
Rv0214|M.tuberculosis_H37Rv DGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPKVLDAAVFGVPDDEMG
MAV_4961|M.avium_104 EGYLYLTDRRHHMIISGGVNIYPQEAENLLVTHPKVLDAAVFGVPDDEMG
Mflv_0419|M.gilvum_PYR-GCK DGFLYLNDRRVDMFTVGGRNVYPAEIESALAEHPGVLSSLVVGLPDDDLG
Mvan_0252|M.vanbaalenii_PYR-1 DGFLYLNDRRVDMFTVGGRNVYPAEIESALAEHPRVLSSLAMGLPDDDLG
MSMEG_0318|M.smegmatis_MC2_155 DGFLYLNDRRVDMFTVGGRNVYPAEIEAALSAHPEVLSCLAVGIPHTDLG
TH_3407|M.thermoresistible__bu DGFLYLSDRRVDMFTVGGRNVYPAEVESALAEHPEVLSALVVGIPDDDLG
MAB_2316|M.abscessus_ATCC_1997 DGYLYMSDRRTDLIVTGGANVFPAEVESVMNGYPGVIDSVVVGLPDDDLG
MMAR_3983|M.marinum_M DGYLYIVDRRVDMIVTGGANVFPAEVESALAGHPGIADVVVIGIADARWG
MUL_3844|M.ulcerans_Agy99 DGYLYIVDRRVDMIITGGANVFPAEVESALAGHPGIADVVVIGIADARWG
MLBr_02546|M.leprae_Br4923 HDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEWG
.. *:: .* .:: ** *::* * * : :* : . ..*: . *
Mb0220|M.bovis_AF2122/97 QRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTD
Rv0214|M.tuberculosis_H37Rv QRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFKCPRSIAFEPQLPRTD
MAV_4961|M.avium_104 QRVMAAVQTVDPGDATDEFGAELLSWLRDRLAHYKCPRAIAFEEQLPRTD
Mflv_0419|M.gilvum_PYR-GCK HVPHAIVQAD-------LSEADVLAFLGERIASYKLPRTVEFTDRPLRDD
Mvan_0252|M.vanbaalenii_PYR-1 QVPHAIVQAHG------LDEAEVIAFLAERIASHKLPRSVEFTDRPLRDD
MSMEG_0318|M.smegmatis_MC2_155 QVPHALVQTAPGS---TLDAAGLRDFLRDAVSSYKVPHTIEFVDEPLRDD
TH_3407|M.thermoresistible__bu QVPYAIVHTADGS---DLDEAAVIGFLRERIAGYKVPRHVEFSATPVRDD
MAB_2316|M.abscessus_ATCC_1997 QSVHAVVHAEPN-----VTEDQLRDYLLDQIVRYKVPRTIEFVADPLRED
MMAR_3983|M.marinum_M RRVHAVVQVAAP-----LTEQQVIEYAKNRLAPYKVPKTVEFVDRIPRTA
MUL_3844|M.ulcerans_Agy99 RRVHAVVQVAAP-----LTEQQVIEYAKNRLAPYKVPKTVEFVDQIPRTA
MLBr_02546|M.leprae_Br4923 ARLRAFVVKKQDAT---IDEDAIKAYVRDHLARYKVPREVIFLEELPRNP
* * : : : : .* *: : * *
Mb0220|M.bovis_AF2122/97 TGKLYKSGLVEKYSV---------
Rv0214|M.tuberculosis_H37Rv TGKLYKSGLVEKYSV---------
MAV_4961|M.avium_104 TGKLFKNGLIEKYSV---------
Mflv_0419|M.gilvum_PYR-GCK AGKARRSAVRDEVLARRA------
Mvan_0252|M.vanbaalenii_PYR-1 AGKARRSAVRDEVIARRSS-----
MSMEG_0318|M.smegmatis_MC2_155 AGKARRTAVRDAVIARLGRAPAAR
TH_3407|M.thermoresistible__bu AGKARRSAVRDEVIARSASRRS--
MAB_2316|M.abscessus_ATCC_1997 SGKVRRSLIREQATARRAAAG---
MMAR_3983|M.marinum_M ATKVNRSAM---IAARGG------
MUL_3844|M.ulcerans_Agy99 ATKVNRSAM---IAARGG------
MLBr_02546|M.leprae_Br4923 TGKVLKRELRDFEVH---------
: * : :