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M. thermoresistible (build 8) TH_3258 (-)

annotation: putative aminoglycoside phosphotransferase
coordinates: 3030046 - 3031062
length: 339

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3258--100% (339)putative aminoglycoside phosphotransferase
M. thermoresistible (build 8)TH_2427-9e-3032.90% (310) PUTATIVE putative phosphotransferase enzyme family protein,
M. thermoresistible (build 8)TH_1657fadE367e-2130.20% (298) POSSIBLE ACYL-CoA DEHYDROGENASE FADE36

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3787cfadE362e-1529.07% (258) acyl-CoA dehydrogenase
M. gilvum PYR-GCKMflv_1204-1e-2128.93% (318) aminoglycoside phosphotransferase
M. tuberculosis H37RvRv3761cfadE362e-1529.07% (258) acyl-CoA dehydrogenase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4589c-2e-2128.25% (315) putative phosphotransferase
M. marinum MMMAR_5304fadE368e-1729.50% (261) acyl-CoA dehydrogenase FadE36
M. avium 104MAV_3946-2e-2730.43% (276) phosphotransferase enzyme family protein, putative
M. smegmatis MC2 155MSMEG_6337-4e-1829.39% (296) phosphotransferase enzyme family protein
M. ulcerans Agy99MUL_2450-6e-1528.63% (262) hypothetical protein MUL_2450
M. vanbaalenii PYR-1Mvan_5603-2e-2129.73% (296) aminoglycoside phosphotransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3787c|M.bovis_AF2122/97           ---------MTSVDRLDGLDLGALDRYLRSLGIGRDGE-LRG---ELISG
Rv3761c|M.tuberculosis_H37Rv        ---------MTSVDRLDGLDLGALDRYLRSLGIGRDGE-LRG---ELISG
MMAR_5304|M.marinum_M               ---------MTSVDRLDGLDLAALDGYLRSLGLGREGE-LRG---ELISG
Mflv_1204|M.gilvum_PYR-GCK          ---------MT---ELEGLDLAALDRHLREVGVPRSGE-LRA---ELIAG
Mvan_5603|M.vanbaalenii_PYR-1       ---------MT---ELEGLDLAALDRHLCDVGVPRSGE-LRA---EFISG
MSMEG_6337|M.smegmatis_MC2_155      ---------MT---SLEGLDLDALDRHLRAEGIARAGD-LRA---ELIAG
MAB_4589c|M.abscessus_ATCC_199      MHKDVSSDSDGPTGDAASLDADAIPTSLSEYLNRELGEQVSV---RRLSA
MAV_3946|M.avium_104                -------------MSSAEPDLDVLRGRLAGAGITALTP---------LSG
TH_3258|M.thermoresistible__bu      -----------VSITATIESRDELHEQVGAWARHHYGPRVRAG-RPVTPE
MUL_2450|M.ulcerans_Agy99           --------------------MTELADRLATVLRPMLGTEVAIDKLRALTG
                                                           :   :                    . 

Mb3787c|M.bovis_AF2122/97           GRSNLTFRVY------DDASSWLVRRPPLHGLTPSAHDMAREYRVVAALG
Rv3761c|M.tuberculosis_H37Rv        GRSNLTFRVY------DDASSWLVRRPPLHGLTPSAHDMAREYRVVAALG
MMAR_5304|M.marinum_M               GRSNLTFRVY------DDATSWLVRRPPLHGLTPSAHDMAREYRVVAALQ
Mflv_1204|M.gilvum_PYR-GCK          GRSNLTFLVG------DDASEWVLRRPPLHGLTPSAHDMAREYKVVAALA
Mvan_5603|M.vanbaalenii_PYR-1       GRSNLTFLVF------DDASKWVLRRPPLHGLTPSAHDMAREYRVVAALA
MSMEG_6337|M.smegmatis_MC2_155      GRSNLTFLVF------DDASKWVLRRPPLHGLTPSAHDMAREYRVVAALA
MAB_4589c|M.abscessus_ATCC_199      GHSNLTYVVTG-----SSGTQWILRRPPFGRLQAGAHDVMREYRVLDALS
MAV_3946|M.avium_104                GASGLTFAGI------RDGRPVVIKVAPPGVAPVGHRDVLRQARIIKALA
TH_3258|M.thermoresistible__bu      GHSGLTVMVPVVLESGQVVDEVVIRLPPKGVKPKRNTDVLRQIPVLRHLA
MUL_2450|M.ulcerans_Agy99           GASRTTWAFDAVTG--HRRRSLILRTGPPDDVHAG---MELEARVQAAAA
                                    * *  *                :::  *          :  :  :     

Mb3787c|M.bovis_AF2122/97           DTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAELEALGSRSVIE
Rv3761c|M.tuberculosis_H37Rv        DTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAELEALGSRSVIE
MMAR_5304|M.marinum_M               DTPVPVARAIALCEDDTVLGAPFQIVEFVAGQVVRRRAQLEVLGSR-AID
Mflv_1204|M.gilvum_PYR-GCK          GTKVPVARAVTMSDDDSVLGAPFQMVERVAGLVVRHTPQLAALGDETVIS
Mvan_5603|M.vanbaalenii_PYR-1       DTAVPVARAVTMRNDDSVLGAPFQMVEYVAGRVVRHTDQLAALGDRATIE
MSMEG_6337|M.smegmatis_MC2_155      GTPVPVARAVTMRNDDSVLGAPFQMVDHVDGRVVRTAAELAALGDQTVID
MAB_4589c|M.abscessus_ATCC_199      TAQVRVPRVTLASTDAEIFGAPFYLMERQDGEVIRDVSPEWFVGSA--RR
MAV_3946|M.avium_104                PTDVPVPRVCWEDAGRPPYTPPLYVMSRVEGDCGEPLFDGWPAVPG--LA
TH_3258|M.thermoresistible__bu      TTEVPVAPVLDPGTDTRWFGRPFLIVRRMPG-ETRSIDDGPGHAPG---P
MUL_2450|M.ulcerans_Agy99           AAGAPVPHVLVADDSPAALGNPFLICDEVGGETIVRRIQRQLDDAG--RQ
                                     : . *. .     .      *: :     *                   

Mb3787c|M.bovis_AF2122/97           GCVDALIRVLVDLHSIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVRLP
Rv3761c|M.tuberculosis_H37Rv        GCVDALIRVLVDLHSIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVRLP
MMAR_5304|M.marinum_M               GCVDSLIRVLVDLHSIDPGAVGLGDFGKPDGYLQRQVRRWGSQWDLVRLP
Mflv_1204|M.gilvum_PYR-GCK          NVVDSLIQVLADLHEVDPESVGLGDFGKASGYLERQVRRWGSQWDLVKRD
Mvan_5603|M.vanbaalenii_PYR-1       KCVDALIKVLADLHSVDPDAVGLSDFGKPSGYLERQVRRWGSQWDLVRRA
MSMEG_6337|M.smegmatis_MC2_155      NCIDALIKALSDLHAVDPYAVGLGDFGKPDGYLERQVRRWGSQWEHVRLP
MAB_4589c|M.abscessus_ATCC_199      ELVLDLAVALAEIHNADPTRLVEAKLGRESGYLARQLKTWGGQWESIKEL
MAV_3946|M.avium_104                DRYRNACRTMAALHRIPPTELGLG--GEPVIDPVAEVHRWSDTLGTVDPA
TH_3258|M.thermoresistible__bu      EHVREAITVLGMLHKSVPAEALTG--WDTVNTYADELRAWDRALERMPND
MUL_2450|M.ulcerans_Agy99           RLLGECAQALAAIHRADAG--------DAGLVHEDPVAHWRERPDAMGES
                                            .:  :*   .                  :  *      :   

Mb3787c|M.bovis_AF2122/97           DDHRD-ADISRLHLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRA
Rv3761c|M.tuberculosis_H37Rv        DDHRD-ADISRLHLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRA
MMAR_5304|M.marinum_M               DDRRD-GDVARLHSALQQAIPTQSRTSIVHGDYRIDNTILDADDPTRVRA
Mflv_1204|M.gilvum_PYR-GCK          DDPSD-ADVRKLHQRLAESVPEQSRASIVHGDYRIDNTILDADDPTKVAA
Mvan_5603|M.vanbaalenii_PYR-1       DDPCD-ADVRRLHERLSAALPPQSRSSIVHGDYRIDNTILDAEDPTKVVA
MSMEG_6337|M.smegmatis_MC2_155      DDARD-DDVRRLHAALADAVPPQSGTSIVHGDYRIDNTVLDAEDATVVRA
MAB_4589c|M.abscessus_ATCC_199      PTGRDLQDHTTITAWLTENYPGDRPAAVVHGDYKLDNVLVDPAT-ARITA
MAV_3946|M.avium_104                LAPGW----PKVRDALLDCAPRAMPPAVVHGDFRLGNLLADGPR---INA
TH_3258|M.thermoresistible__bu      DWRTA---CGRLRERLADVLPVEAATGLVHGDYQFSNLLYDATR---ITA
MUL_2450|M.ulcerans_Agy99           TATFE-----WAFRWLDAHRPAESAPVLVHGDYRMGNLIVEGSR---LAA
                                                   *    *    . :****:::.* : :      : *

Mb3787c|M.bovis_AF2122/97           VVDWELSTLGDPLSDAALMCVYRDP---ALDLIVHAQAAWTSPLLPAADE
Rv3761c|M.tuberculosis_H37Rv        VVDWELSTLGDPLSDAALMCVYRDP---ALDLIVHAQAAWTSPLLPAADE
MMAR_5304|M.marinum_M               VVDWELSTLGDPLSDAALMCVYRDP---ALDLIVNTQAAWTSPLLPTADE
Mflv_1204|M.gilvum_PYR-GCK          VLDWEMSTLGDPLSDAALMCVYRLP---AFN-EVHDDAAWACDLMPPTDD
Mvan_5603|M.vanbaalenii_PYR-1       VLDWEMSTLGDPLSDAALMCVYRHP---MFN-MVHADAAWASELIPDADA
MSMEG_6337|M.smegmatis_MC2_155      VLDWEMSTLGDPLSDAALMCVYRNP---MFG-HIHTDAAWSSDLVPPADE
MAB_4589c|M.abscessus_ATCC_199      VLDWEMATVGDPLADLGYLLYMTPEPGGEVAMSELTGSVTAQEGCPSHTE
MAV_3946|M.avium_104                VIDWEIWSIGDPRIDVGWFLINCDP-------DTYRRVTPSDGAVPSTAE
TH_3258|M.thermoresistible__bu      VLDWEVATLGPQLLDLGWFVTINDQ--------DSWAHRVATAGIPPTEV
MUL_2450|M.ulcerans_Agy99           VLDWELVHVGAGYEDLAWFCVRAWR--------FGAPASYGAGGLGSIED
                                    *:***:  :*    * . :                               

Mb3787c|M.bovis_AF2122/97           LADRYSLVSGQPLGHWE-----FYMALAYFKLAIIAAGIDYRRRMSEQAE
Rv3761c|M.tuberculosis_H37Rv        LADRYSLVSGQPLGHWE-----FYMALAYFKLAIIAAGIDYRRRMSEQAE
MMAR_5304|M.marinum_M               LADRYSLVSGMSLGHWE-----FYMALAYFKLAIIAAGIDFRRRMSELAD
Mflv_1204|M.gilvum_PYR-GCK          LAQRYALASGKPLDHWD-----FYMALGYFKIAIIAAGIAYRARMGGGV-
Mvan_5603|M.vanbaalenii_PYR-1       LADKYSRAAGQPLDHWD-----FYMALAYFKLAIIGAGIAYRAREAG-V-
MSMEG_6337|M.smegmatis_MC2_155      LADRYSKVSGRDLAHWD-----FYMALAYFKLAIIAAGIDYRRREGA---
MAB_4589c|M.abscessus_ATCC_199      IAQAYREARSGDQSYWTPEDLVYYQVLGGWKLATLLE-VSYQRHLAGTT-
MAV_3946|M.avium_104                LADLYLHELGCDAGDLD-----WFSALACFKSAATWSLIVKHNRRRSSP-
TH_3258|M.thermoresistible__bu      IVDWYESAADRAVDKGE---LAAACALAAYRFAVIAGLNLSLHRTGRRV-
MUL_2450|M.ulcerans_Agy99           FLRAYERAGGTAVDRGAFH---WWLVLATLRWGVICQYQAWRHLSGQAR-
                                    :   *    .               .*.  : .                 

Mb3787c|M.bovis_AF2122/97           GKDTAAESVPDVVAPLIARGLAEIAKKSG
Rv3761c|M.tuberculosis_H37Rv        GKDTAAESVPDVVAPLIARGLAEIAKKSG
MMAR_5304|M.marinum_M               GKTDASDEAPEVVSPLISRGLAEIAKPVS
Mflv_1204|M.gilvum_PYR-GCK          --AEGTDEVDRAVRPFVAAGLHILS----
Mvan_5603|M.vanbaalenii_PYR-1       --VDDTDKVGEAVAPLIAAGLSQLA----
MSMEG_6337|M.smegmatis_MC2_155      ---DGPEQVGEAVAPMIAAGLAALG----
MAB_4589c|M.abscessus_ATCC_199      -DDPFFAELDEGVPRLLSVARSLIPAAG-
MAV_3946|M.avium_104                --RAELESMTTTLPRLLDRAGALLARRR-
TH_3258|M.thermoresistible__bu      --DPHWEKIAPSIPRLVECGLRRLRR---
MUL_2450|M.ulcerans_Agy99           --SVELATTGRRVCENEWDLPDLLEGA--
                                                :          :