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M. thermoresistible (build 8) TH_2122 (ponA)

annotation: PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE)
coordinates: 4171248 - 4173884
length: 879

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2122ponA-100% (879)PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE)
M. thermoresistible (build 8)TH_3201-7e-4627.15% (652) PUTATIVE glycosyl transferase, family 51
M. thermoresistible (build 8)TH_1396-2e-0725.89% (336) POSSIBLE PENICILLIN-BINDING LIPOPROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3707ponA20.078.97% (756) bifunctional membrane-associated penicillin-binding protein
M. gilvum PYR-GCKMflv_1365-0.080.50% (764) glycosyl transferase family protein
M. tuberculosis H37RvRv3682ponA20.078.97% (756) bifunctional membrane-associated penicillin-binding protein
M. leprae Br4923MLBr_02308pon10.077.63% (742) penicillin binding protein (class A)
M. abscessus ATCC 19977MAB_0408c-0.069.34% (786) bifunctional membrane-associated penicillin-binding protein
M. marinum MMMAR_5171ponA20.078.00% (759) bifunctional membrane-associated penicillin- binding
M. avium 104MAV_0446-0.079.42% (729) transglycosylase
M. smegmatis MC2 155MSMEG_6201-0.087.12% (730) transglycosylase
M. ulcerans Agy99MUL_4257ponA20.077.60% (759) bifunctional membrane-associated penicillin- binding
M. vanbaalenii PYR-1Mvan_5442-0.080.90% (759) glycosyl transferase family protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_2122|M.thermoresistible__bu      MPEDPPTAPTESTRAATVIKLAWCCLLAAVIAAALMFPVVGGIGLLSNRA
MSMEG_6201|M.smegmatis_MC2_155      -----------------------------MLAAALMFPVVGGFGLMSNRA
Mflv_1365|M.gilvum_PYR-GCK          MPEQPPTQP---PRAVTVIKLAWCVVLASVIVAGLLFPVVGGFGLVSNRA
Mvan_5442|M.vanbaalenii_PYR-1       MPEHPSGPP---PRAVTVIKLAWCVLLASVVAAGLMFPVVGGFGLMPNRA
Mb3707|M.bovis_AF2122/97            MPERL-------PAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRA
Rv3682|M.tuberculosis_H37Rv         MPERL-------PAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRA
MMAR_5171|M.marinum_M               MSERP-------PAALTLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRA
MUL_4257|M.ulcerans_Agy99           MSERP-------PAALSLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRA
MAV_0446|M.avium_104                ------------------------------MATALLFPVAGGIGLVSNRA
MLBr_02308|M.leprae_Br4923          MSERL-------PAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRA
MAB_0408c|M.abscessus_ATCC_199      MPERLSP---QIPPSVTLAKLAGCGLVAAVILAGLMFPFAGGFGLASNRA
                                                                  : :.: **..**:*: .***

TH_2122|M.thermoresistible__bu      SDVVANGSAQLVEGDVPAVSTMVDAEGNPIAWLYSQRRWEVPSEEIADTM
MSMEG_6201|M.smegmatis_MC2_155      SDVVANGSAALVEGEVPQVSTMVDAKGNTIAWLYSQRRFEVPSEQIANTM
Mflv_1365|M.gilvum_PYR-GCK          SDVVANGSAQLVEGEVPQVSTMTDSKGNIIAWLYSQRRFEVPSDQIANTM
Mvan_5442|M.vanbaalenii_PYR-1       SDVVANGSAQLVEGEVPQVSTMTDAKGNVIAWLYNQRRFEVPSDQIANTM
Mb3707|M.bovis_AF2122/97            SEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
Rv3682|M.tuberculosis_H37Rv         SEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MMAR_5171|M.marinum_M               SEVVANGSAQLLQGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MUL_4257|M.ulcerans_Agy99           SEVVANGSAQLLQGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MAV_0446|M.avium_104                SEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MLBr_02308|M.leprae_Br4923          SEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPTDKIANTM
MAB_0408c|M.abscessus_ATCC_199      SDVVANGSTQLLQGEVPAVTTVEDAKGNKIAYLYTQRRFEVSADEIADTM
                                    *:******: *::*:** *:*: *::** **:**.***:**.:::**:**

TH_2122|M.thermoresistible__bu      KLAIVAIEDKRFAEHNGVDWQGTLTGLTGYLRGDSDTRGGSTLEQQYVKN
MSMEG_6201|M.smegmatis_MC2_155      KLAIVSIEDKRFAEHNGVDWQGTLTGLSGYLSGNPDTRGGSTIEQQYVKN
Mflv_1365|M.gilvum_PYR-GCK          KLAIVSIEDKRFADHNGVDWQGTLTGLSGYLSGNLDTRGGSTIEQQYVKN
Mvan_5442|M.vanbaalenii_PYR-1       KLAIVSIEDKRFADHNGVDWQGTLTGLSGYLSGNLDTRGGSTIEQQYVKN
Mb3707|M.bovis_AF2122/97            KLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKN
Rv3682|M.tuberculosis_H37Rv         KLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKN
MMAR_5171|M.marinum_M               KLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQYIKN
MUL_4257|M.ulcerans_Agy99           KLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQYIKN
MAV_0446|M.avium_104                KLAIVSIEDKRFADHNGVDWKGTLTGLAGYARGDVDTRGGSTIEQQYIKN
MLBr_02308|M.leprae_Br4923          KLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKN
MAB_0408c|M.abscessus_ATCC_199      KLALLSIEDKRFTSHNGVDWKGTLGGLAGYASGDEDTRGGSTIEQQYVKN
                                    ***:::******:.*.**** *** **:**  *: *******:****:**

TH_2122|M.thermoresistible__bu      YQLLVVAQTDAEKRAAIETTPARKLREIRMALTLDKTLTKPEILTRYLNL
MSMEG_6201|M.smegmatis_MC2_155      YQLLVVAQTDAERRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL
Mflv_1365|M.gilvum_PYR-GCK          YQLLVIAQTDAEKRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL
Mvan_5442|M.vanbaalenii_PYR-1       YQLLVIAQTDAEKRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL
Mb3707|M.bovis_AF2122/97            YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNL
Rv3682|M.tuberculosis_H37Rv         YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNL
MMAR_5171|M.marinum_M               YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MUL_4257|M.ulcerans_Agy99           YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MAV_0446|M.avium_104                YQLLVTAKTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MLBr_02308|M.leprae_Br4923          YQLLVTAQTDAEKRAAVETTPARKLREIRIALTLDKTFTKPEILTRYLNL
MAB_0408c|M.abscessus_ATCC_199      YQLLVVAKTDAERKAAIETTPARKLREIRMALRLDQTFTKQEILTRYLNL
                                    ***** *:****::**:************:** **:*:** *********

TH_2122|M.thermoresistible__bu      VSFGNGAYGIQDAAQTYFGINASELDWHQAALLAGLVQSTTALNPYTNPD
MSMEG_6201|M.smegmatis_MC2_155      VSFGNGAYGIQDAAQTYFGVNASELNWQQAALLAGMVQSTSALNPYTNPD
Mflv_1365|M.gilvum_PYR-GCK          VSFGNNAFGVQDAAQTYFGINATDLNWQQAALLAGMVQSTSTLNPYTNPD
Mvan_5442|M.vanbaalenii_PYR-1       VSFGNNAFGVQDAAQTYFGVNASELNWQQAALLAGMVQSTSTLNPYTNPD
Mb3707|M.bovis_AF2122/97            VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPD
Rv3682|M.tuberculosis_H37Rv         VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPD
MMAR_5171|M.marinum_M               VSFGNNSFGVQDAAQTYFGINASELNWQQSALLAGMVQSTSTLNPYTNPD
MUL_4257|M.ulcerans_Agy99           VSFGNNSFGVQDAAQTYFGINASELNWQQSALLAGMVQSTSTLNPYTNPD
MAV_0446|M.avium_104                VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSALNPYTNPE
MLBr_02308|M.leprae_Br4923          VSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYTNPE
MAB_0408c|M.abscessus_ATCC_199      VSFGNNSFGVQDAAQTYFGVDAKDLNWQQAALLAGMVQSTSGLNPYVNPE
                                    *****.::*:*********::*.:*:*:*:*****:****: ****.**:

TH_2122|M.thermoresistible__bu      GALARRNLVLDTMIDQLPQEAEALRAAKEQPLGILPRPNELPRGCIAAGD
MSMEG_6201|M.smegmatis_MC2_155      GALARRNLVLDTMIQNIPQEAEALRAAKEQPLGILPQPNELPRGCIAAGD
Mflv_1365|M.gilvum_PYR-GCK          GALARRNVVLDTMIENLPEYADELRAARQEPLGVLPQPKELPRGCIAAGD
Mvan_5442|M.vanbaalenii_PYR-1       GALARRNVVLDTMIENLPEHADELRTAKQQPLGILPQPKELPRGCIAAGD
Mb3707|M.bovis_AF2122/97            GALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGD
Rv3682|M.tuberculosis_H37Rv         GALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGD
MMAR_5171|M.marinum_M               GALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQPNELPRGCIAAGD
MUL_4257|M.ulcerans_Agy99           GALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQPNELPRGCIAAGD
MAV_0446|M.avium_104                GALARRNLVLDTMIENIPQEADALRAAKAAPLGILPQPNELPRGCIAAGD
MLBr_02308|M.leprae_Br4923          GALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGD
MAB_0408c|M.abscessus_ATCC_199      RALARRNLVLDTMIANSPDKKGELLAAKAQPLGVLPQPNELPRGCIAAGD
                                     ******:****** : *     * :*:  ***:**:*:***********

TH_2122|M.thermoresistible__bu      RAFFCDYVLEYLARAGISKEQVAKGGYLIKTTLDPEVQRAVKSAIDQYAR
MSMEG_6201|M.smegmatis_MC2_155      RAFFCDYVLEYLARAGISKEQVAKGGYLIKTTLDPDVQSSVKSAIDSIAA
Mflv_1365|M.gilvum_PYR-GCK          RAFFCDYALDYLARAGISKDQVAKGGYMIKTTLDPDVQASVKNAITQYAS
Mvan_5442|M.vanbaalenii_PYR-1       RAFFCDYALDYLARAGISKDQVAKGGYLIKTTLEPDVQASVKNAINEFAS
Mb3707|M.bovis_AF2122/97            RAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYAS
Rv3682|M.tuberculosis_H37Rv         RAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYAS
MMAR_5171|M.marinum_M               RAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFAS
MUL_4257|M.ulcerans_Agy99           RAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFAS
MAV_0446|M.avium_104                RAYFCDYVQEYLSRAGISKEQVARGGYLIKTTLDPDVQIPVKAAIDKFAS
MLBr_02308|M.leprae_Br4923          RAFFCDYVQEYLSHAGISKDRLAKGGYLIRTTLDPNVQAPVKAAIDKFAS
MAB_0408c|M.abscessus_ATCC_199      RAFFCDYVLDYLAKSGISKDQVMKGGYLIRTTLDPDVQNSVKQAVSHVAD
                                    **:****. :**:::****:::  ***:*:***:*:** .** *:   * 

TH_2122|M.thermoresistible__bu      PDANGVASVMSVIRPGKESHPVLAMASSRHYGLNSEAGETMQPQPFSLVG
MSMEG_6201|M.smegmatis_MC2_155      PDTPGVASVMSVIKPGKESHPVLAMASNRTYGLDTERGETMQPQPFSLVG
Mflv_1365|M.gilvum_PYR-GCK          PDLPGVASVMSVVKPGKDSHPVLAMASNRTYGLNLDAGETMQPQPFSLVG
Mvan_5442|M.vanbaalenii_PYR-1       PDLPGVASVMSVIRPGKDSHPVLAMASNRTYGLNLDAGETMQPQPFSLVG
Mb3707|M.bovis_AF2122/97            PNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVG
Rv3682|M.tuberculosis_H37Rv         PNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVG
MMAR_5171|M.marinum_M               PTLPGISSVMSVIKPGKESHQVLAMASNRKYGLDINAGETMRPQPFSLVG
MUL_4257|M.ulcerans_Agy99           PTLPGISSVMSVIKPGKESHQVLAMASNRAYGLDINAGETMRPQPFSLVG
MAV_0446|M.avium_104                PTLPGISSVMSVIQPGKTSHKVMAMASNRTYGLDVDAGQTMRPQPFSLVG
MLBr_02308|M.leprae_Br4923          PNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVG
MAB_0408c|M.abscessus_ATCC_199      PGLNGIANVMSVIKPGQTSHPILAMASSRTYGLDGNAFQTMQPQPFSLVG
                                    *   *::.****: **: :* ::**.*.* ***: :  :**:**.*****

TH_2122|M.thermoresistible__bu      HGAGSVFKIFTTAAAMEMGMGINTQLEAPAFFQAKGLGSS-DTPGCPAAT
MSMEG_6201|M.smegmatis_MC2_155      NGAGSVFKIFTVAAAMEMGMGINTQLPVPARFEAKGLGSG-GARGCPPAT
Mflv_1365|M.gilvum_PYR-GCK          NGAGSVFKIFTTAAAMEMGMGINAQLDSPSRFEAKGLGSG-GARGCPPAT
Mvan_5442|M.vanbaalenii_PYR-1       NGAGSVFKIFTTAAAMEMGMGINAQLDSPSRFEAKGLGSG-GARGCPPAT
Mb3707|M.bovis_AF2122/97            DGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSG-GAKGCPKET
Rv3682|M.tuberculosis_H37Rv         DGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSG-GAKGCPKET
MMAR_5171|M.marinum_M               DGAGSIFKIFTTAAALDMGMGINAQLDVPGRFQGKGLGSG-GAKGCPKDT
MUL_4257|M.ulcerans_Agy99           DGAGSIFKIFTTAAALDMGMGISAQLDVPGRFQGKGLGSG-GAKGCPKDT
MAV_0446|M.avium_104                DGAGSVFKIFTTAAALDMGMGINATLEVPGRFQAKGMGSG-GAKGCPKDT
MLBr_02308|M.leprae_Br4923          DGAGSVFKIFTTAAALDMGMGINAKLEVPSRFQAKGMGSG-GAKGCPKET
MAB_0408c|M.abscessus_ATCC_199      DGAGSIFKIFTVAAAMDMGMGINTVLDVPPTFAAKGLGSSDGSKGCPKDN
                                    .****:*****.***::*****.: *  *  * .**:**. .: ***  .

TH_2122|M.thermoresistible__bu      WCVRNAGSYRGSMNVTDALATSPNTAFAKLISQIGVPRTVDMAVRLGLRS
MSMEG_6201|M.smegmatis_MC2_155      WCVQNAGGYRGSMSVTDALATSPNTAFAKLISQIGVQRAVDMAVRLGLRS
Mflv_1365|M.gilvum_PYR-GCK          WCVQNAGNYRGTMSVTDALATSPNTAFAKLIAQVGVQRTVDMAVRLGLRS
Mvan_5442|M.vanbaalenii_PYR-1       WCVQNAGNYRGTMNVTDALATSPNTAFAKLIAQVGVQRTVDMAVKLGLRS
Mb3707|M.bovis_AF2122/97            WCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRS
Rv3682|M.tuberculosis_H37Rv         WCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRS
MMAR_5171|M.marinum_M               WCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGLRS
MUL_4257|M.ulcerans_Agy99           WCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGLRS
MAV_0446|M.avium_104                WCVVNAGNYKGSMNVTEALATSPNTAFAKLIQQVGVTRTVDMAIKLGLRS
MLBr_02308|M.leprae_Br4923          WCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVARTVDMAIKLGLRS
MAB_0408c|M.abscessus_ATCC_199      WCVKNVGNYRSPMSVTDALATSPNTAFAKLIQSIGVSKAVDMAVKLGMRS
                                    *** *.*.*:..*.**:************** .:** ::****::**:**

TH_2122|M.thermoresistible__bu      YAQPGTARDYDPNSDESIADWVKRQNIGSFTLGPIEVNALELSNVAATLA
MSMEG_6201|M.smegmatis_MC2_155      YAQPGTARDYDPESSESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
Mflv_1365|M.gilvum_PYR-GCK          YALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
Mvan_5442|M.vanbaalenii_PYR-1       YALPGTARDYDPESNESLADFVKRQNLGSFTLGPIEVNALELSNVAATLA
Mb3707|M.bovis_AF2122/97            YANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLA
Rv3682|M.tuberculosis_H37Rv         YANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLA
MMAR_5171|M.marinum_M               YANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
MUL_4257|M.ulcerans_Agy99           YANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
MAV_0446|M.avium_104                YADPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
MLBr_02308|M.leprae_Br4923          YTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLA
MAB_0408c|M.abscessus_ATCC_199      YAEPGTAKPYDPEGDESLAEYIKKYNLGSFTLGPIQINPLELSNVAATLA
                                    *: ****: *:*:..**:*:::*: *:********::*.***********

TH_2122|M.thermoresistible__bu      SGGVWCPPNPIDKVYDRHGNEVSVTTETCEQVVPEGLANTLANAMSEDDR
MSMEG_6201|M.smegmatis_MC2_155      SGGTWCPPNPIAQVVDRNGNEVAVTTETCEQVVPEGLANTLANAMSKDDT
Mflv_1365|M.gilvum_PYR-GCK          SGGMWCPPNPIAEVYDRYGEPVSVTTETCEQAVPEGLANTLANAMSKDDT
Mvan_5442|M.vanbaalenii_PYR-1       SGGMWCPPNPIAEVRDRYGELVSVTTETCEQVVPEGLANTLAVAMSKDDT
Mb3707|M.bovis_AF2122/97            SGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAV
Rv3682|M.tuberculosis_H37Rv         SGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAV
MMAR_5171|M.marinum_M               SGGVWCPPNPVDKLIDRNGNEVAVTTETCDQVVPEGLANTLANAMSKDAV
MUL_4257|M.ulcerans_Agy99           SGGVWCPPNPVDKLIDRNGNEVAVTTETCDQVVPEGLANTLANAMSKDAV
MAV_0446|M.avium_104                SGGTWCPPNPIDKLIDRKGNEVAVTTETCDQVVPEGLANTMANAMSKDAV
MLBr_02308|M.leprae_Br4923          SGGMWCPPNPIDKLFDRNGNEVAVTVETCDRVVPEGLANTLANAMSKDTK
MAB_0408c|M.abscessus_ATCC_199      SGGKWCPPNPIDKVFDRHGKEVPTTVEACEQVVPTGLANTLANALSKDDQ
                                    *** ******: :: ** *: *..*.*:*::.** *****:* *:*:*  

TH_2122|M.thermoresistible__bu      GAGTAAGAAASVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYDDS
MSMEG_6201|M.smegmatis_MC2_155      GSGTAAASAGSVGWNLPMSGKTGTTEDNRSSAFLGFTNQYAAANYIYDDS
Mflv_1365|M.gilvum_PYR-GCK          GAGTAAGAAGSVGWNLPMSGKTGTTEANRSSAFLGFTNRYAAASYIYDDS
Mvan_5442|M.vanbaalenii_PYR-1       GAGTAAGAAGSTGWSLPMSGKTGTTESNRSSAFLGFTNQYAAASYIYDDS
Mb3707|M.bovis_AF2122/97            GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
Rv3682|M.tuberculosis_H37Rv         GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
MMAR_5171|M.marinum_M               GGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
MUL_4257|M.ulcerans_Agy99           GGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
MAV_0446|M.avium_104                GGGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDS
MLBr_02308|M.leprae_Br4923          GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDS
MAB_0408c|M.abscessus_ATCC_199      PGGTAAGSAGSVGWNLPLSSKTGTTEAHRSSAFLGYTNNLAGASYIYDDS
                                     .***:.:*.:.**.**:*.****** :**:.*:*:**. *.*.******

TH_2122|M.thermoresistible__bu      NSPGELCSFPLRRCGSGDLFGGNEPARTWFAAMKPIAEKFGPVALPPTDP
MSMEG_6201|M.smegmatis_MC2_155      PNPSELCSFPLRQCGSGNLFGGNEPARTWFTAMKPIAESFGPVALPPTDP
Mflv_1365|M.gilvum_PYR-GCK          TAPTELCSFPLRQCGSGNLFGGNEPARTWFSAMQPIATAFGDVTLPPTDP
Mvan_5442|M.vanbaalenii_PYR-1       TAPTELCSFPLRQCGSGNLFGGNEPARTWFTAMTPIATAFGDVTLPPTDP
Mb3707|M.bovis_AF2122/97            SSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDP
Rv3682|M.tuberculosis_H37Rv         SSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDP
MMAR_5171|M.marinum_M               TNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDP
MUL_4257|M.ulcerans_Agy99           TNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDP
MAV_0446|M.avium_104                PNPTDLCSAPLRHCGEGDLYGGNEPARTWFTAMKPIATNFGPVQLPPTDP
MLBr_02308|M.leprae_Br4923          TSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDP
MAB_0408c|M.abscessus_ATCC_199      TTPGDLCSFPLRKCGDGNLYGGNEPARAWFEAMKPIADNYGPTVLPPTEP
                                      * :*** ***:*..*:*:*****:*:** *: ***  :* . ****:*

TH_2122|M.thermoresistible__bu      RYVDGGPGSRVPSVSGLSEEAARQRLRDAGFQVADGVATVNSSARRGTVV
MSMEG_6201|M.smegmatis_MC2_155      RYVDGGPGSRVPSVSGLTEEAARQRLKEAGFQVADQASYVNSGARSGTVV
Mflv_1365|M.gilvum_PYR-GCK          RYVEGAPGSKVPSVAGMDQDTARARLREAGFQVADQATPVNSSSRYGTVV
Mvan_5442|M.vanbaalenii_PYR-1       RYVDGAPGSKVPSVAGMNQDTARQRLREAGFQVADQPTPVNSTAPYGAVV
Mb3707|M.bovis_AF2122/97            RYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVV
Rv3682|M.tuberculosis_H37Rv         RYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVV
MMAR_5171|M.marinum_M               RYVDGAPGSRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEVV
MUL_4257|M.ulcerans_Agy99           RYVDGAPGSRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEAV
MAV_0446|M.avium_104                RYVDGAPGSRVPSVAGLDIDAARQRIKEAGFQVADQNNFVNSSAKQGEVV
MLBr_02308|M.leprae_Br4923          RYVDGSPGSQVPSVTGLDLDAARQRLKGAGFQVADQPTLINSTAKLGAVV
MAB_0408c|M.abscessus_ATCC_199      RYVEGGPGSKVPSINGLREPEARDVLKKAGFRVADQASSVNSTAPFNEVV
                                    ***:*.***:***: *:    **  :: ***:***    :** :  . .*

TH_2122|M.thermoresistible__bu      GTNPSGQTIPXXYPTQFLRADLDALGVIPADKLLEVPDGTRILIAGAVTH
MSMEG_6201|M.smegmatis_MC2_155      GTTPSGQTIPGSIITIQLSNGIPPPPPPPVN--IPLPGGP----------
Mflv_1365|M.gilvum_PYR-GCK          GTAPSGQTVPGSIVTIQISNGIAPAPPPPPAG-APPPGGPP---------
Mvan_5442|M.vanbaalenii_PYR-1       GTSPTGQTVPGSIITIQISNGIAPPPPPPPPG-APP-GLPP---------
Mb3707|M.bovis_AF2122/97            GTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPP----------
Rv3682|M.tuberculosis_H37Rv         GTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPP----------
MMAR_5171|M.marinum_M               GTSPSGQTIPGSIITIQISNGIPPAPPPPP---EGEPPPP----------
MUL_4257|M.ulcerans_Agy99           GTSPSGQTIPGSIITIQISNGIPPAPPPPP---EGEPPPP----------
MAV_0446|M.avium_104                GTTPSGATIPGSIITIQVSNGIPPAPPPPP----EGAPPP----------
MLBr_02308|M.leprae_Br4923          GTTPSGQTIPGSIITIQTSSGIPPAPPPPP---EGGPPMPP---------
MAB_0408c|M.abscessus_ATCC_199      GTSPSGTTIPGSVITILMSNGIPPAPPPLVIPGIPGAPPGE---------
                                    ** *:* *:*    *     .: .                          

TH_2122|M.thermoresistible__bu      RQRPATAQGVTFLN-LEDETGMVNVLCSPGVWARHRRLAQTAPALLVRGI
MSMEG_6201|M.smegmatis_MC2_155      ---PEIGQTVVEIPGLPPIT--VPVLGPP---------PPPPPP------
Mflv_1365|M.gilvum_PYR-GCK          ---PPAGETVIQIPGLPPIT--VPVLGPP---------PPPPPPPG----
Mvan_5442|M.vanbaalenii_PYR-1       ---PPVGQTVIQIPGLPPIT--VPVLGPP---------PPPPPPPG----
Mb3707|M.bovis_AF2122/97            -----VGSQVVEIPGLPPIT--IPLLAPP----------PPAP--PP---
Rv3682|M.tuberculosis_H37Rv         -----VGSQVVEIPGLPPIT--IPLLAPP----------PPAP--PP---
MMAR_5171|M.marinum_M               -----VGSQVVEIPGLPPIT--IPLLAPP----------PP---------
MUL_4257|M.ulcerans_Agy99           -----VGSQVVEIPGLPPIT--IPLLAPP----------PP---------
MAV_0446|M.avium_104                -----VGSQVVEIPGLPPIT--IPLLAPP----------PPAPGQPPP--
MLBr_02308|M.leprae_Br4923          ----SVGSQVIEIPGLPPIT--IPLLAPP---------------------
MAB_0408c|M.abscessus_ATCC_199      -----MTTTIVNIPGLPPIT--VPVLAPP-------------P-------
                                             :  :  *   *  : :* .*                     

TH_2122|M.thermoresistible__bu      VQNATGAVTVVADRMRRLELRVGSRSRDFR
MSMEG_6201|M.smegmatis_MC2_155      ------------------------------
Mflv_1365|M.gilvum_PYR-GCK          ------------------------------
Mvan_5442|M.vanbaalenii_PYR-1       ------------------------------
Mb3707|M.bovis_AF2122/97            ------------------------------
Rv3682|M.tuberculosis_H37Rv         ------------------------------
MMAR_5171|M.marinum_M               ------------------------------
MUL_4257|M.ulcerans_Agy99           ------------------------------
MAV_0446|M.avium_104                ------------------------------
MLBr_02308|M.leprae_Br4923          ------------------------------
MAB_0408c|M.abscessus_ATCC_199      ------------------------------