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MSERPPAALSLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRASEVVANGSAQLLQGEVPAVSTMVDAKG NTIAWLYSQRRFEVPSDKIANTMKLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQY IKNYQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNLVSFGNNSFGVQDAAQTY FGINASELNWQQSALLAGMVQSTSTLNPYTNPDGALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQ PNELPRGCIAAGDRAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFASPTLPGIS SVMSVIKPGKESHQVLAMASNRAYGLDINAGETMRPQPFSLVGDGAGSIFKIFTTAAALDMGMGISAQLD VPGRFQGKGLGSGGAKGCPKDTWCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGL RSYANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLASGGVWCPPNPVDKLIDRN GNEVAVTTETCDQVVPEGLANTLANAMSKDAVGGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTN RYAAANYIYDDSTNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDPRYVDGAPG SRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEAVGTSPSGQTIPGSIITIQISNGIPPAPPP PPEGEPPPPVGSQVVEIPGLPPITIPLLAPPPP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4257 | ponA2 | - | 100% (803) | bifunctional membrane-associated penicillin- binding protein 1A/1B PonA2 |
M. ulcerans Agy99 | MUL_0068 | ponA1 | 2e-49 | 26.23% (770) | bifunctional penicillin-binding protein 1A/1B PonA1 |
M. ulcerans Agy99 | MUL_3508 | pbpB | 1e-10 | 24.23% (326) | penicillin-binding membrane protein PbpB |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3707 | ponA2 | 0.0 | 90.69% (806) | bifunctional membrane-associated penicillin-binding protein |
M. gilvum PYR-GCK | Mflv_1365 | - | 0.0 | 79.01% (805) | glycosyl transferase family protein |
M. tuberculosis H37Rv | Rv3682 | ponA2 | 0.0 | 90.69% (806) | bifunctional membrane-associated penicillin-binding protein |
M. leprae Br4923 | MLBr_02308 | pon1 | 0.0 | 86.67% (803) | penicillin binding protein (class A) |
M. abscessus ATCC 19977 | MAB_0408c | - | 0.0 | 72.00% (807) | bifunctional membrane-associated penicillin-binding protein |
M. marinum M | MMAR_5171 | ponA2 | 0.0 | 99.50% (803) | bifunctional membrane-associated penicillin- binding |
M. avium 104 | MAV_0446 | - | 0.0 | 91.03% (780) | transglycosylase |
M. smegmatis MC2 155 | MSMEG_6201 | - | 0.0 | 81.63% (784) | transglycosylase |
M. thermoresistible (build 8) | TH_2122 | ponA | 0.0 | 77.60% (759) | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING |
M. vanbaalenii PYR-1 | Mvan_5442 | - | 0.0 | 80.07% (803) | glycosyl transferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1365|M.gilvum_PYR-GCK MPEQPPTQP---PRAVTVIKLAWCVVLASVIVAGLLFPVVGGFGLVSNRA Mvan_5442|M.vanbaalenii_PYR-1 MPEHPSGPP---PRAVTVIKLAWCVLLASVVAAGLMFPVVGGFGLMPNRA MSMEG_6201|M.smegmatis_MC2_155 -----------------------------MLAAALMFPVVGGFGLMSNRA TH_2122|M.thermoresistible__bu MPEDPPTAPTESTRAATVIKLAWCCLLAAVIAAALMFPVVGGIGLLSNRA MUL_4257|M.ulcerans_Agy99 MSERP-------PAALSLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRA MMAR_5171|M.marinum_M MSERP-------PAALTLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRA Mb3707|M.bovis_AF2122/97 MPERL-------PAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRA Rv3682|M.tuberculosis_H37Rv MPERL-------PAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRA MAV_0446|M.avium_104 ------------------------------MATALLFPVAGGIGLVSNRA MLBr_02308|M.leprae_Br4923 MSERL-------PAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRA MAB_0408c|M.abscessus_ATCC_199 MPERLSP---QIPPSVTLAKLAGCGLVAAVILAGLMFPFAGGFGLASNRA : :.: **..**:*: .*** Mflv_1365|M.gilvum_PYR-GCK SDVVANGSAQLVEGEVPQVSTMTDSKGNIIAWLYSQRRFEVPSDQIANTM Mvan_5442|M.vanbaalenii_PYR-1 SDVVANGSAQLVEGEVPQVSTMTDAKGNVIAWLYNQRRFEVPSDQIANTM MSMEG_6201|M.smegmatis_MC2_155 SDVVANGSAALVEGEVPQVSTMVDAKGNTIAWLYSQRRFEVPSEQIANTM TH_2122|M.thermoresistible__bu SDVVANGSAQLVEGDVPAVSTMVDAEGNPIAWLYSQRRWEVPSEEIADTM MUL_4257|M.ulcerans_Agy99 SEVVANGSAQLLQGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM MMAR_5171|M.marinum_M SEVVANGSAQLLQGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM Mb3707|M.bovis_AF2122/97 SEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM Rv3682|M.tuberculosis_H37Rv SEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM MAV_0446|M.avium_104 SEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM MLBr_02308|M.leprae_Br4923 SEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPTDKIANTM MAB_0408c|M.abscessus_ATCC_199 SDVVANGSTQLLQGEVPAVTTVEDAKGNKIAYLYTQRRFEVSADEIADTM *:******: *::*:** *:*: *::** **:**.***:**.:::**:** Mflv_1365|M.gilvum_PYR-GCK KLAIVSIEDKRFADHNGVDWQGTLTGLSGYLSGNLDTRGGSTIEQQYVKN Mvan_5442|M.vanbaalenii_PYR-1 KLAIVSIEDKRFADHNGVDWQGTLTGLSGYLSGNLDTRGGSTIEQQYVKN MSMEG_6201|M.smegmatis_MC2_155 KLAIVSIEDKRFAEHNGVDWQGTLTGLSGYLSGNPDTRGGSTIEQQYVKN TH_2122|M.thermoresistible__bu KLAIVAIEDKRFAEHNGVDWQGTLTGLTGYLRGDSDTRGGSTLEQQYVKN MUL_4257|M.ulcerans_Agy99 KLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQYIKN MMAR_5171|M.marinum_M KLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQYIKN Mb3707|M.bovis_AF2122/97 KLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKN Rv3682|M.tuberculosis_H37Rv KLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKN MAV_0446|M.avium_104 KLAIVSIEDKRFADHNGVDWKGTLTGLAGYARGDVDTRGGSTIEQQYIKN MLBr_02308|M.leprae_Br4923 KLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKN MAB_0408c|M.abscessus_ATCC_199 KLALLSIEDKRFTSHNGVDWKGTLGGLAGYASGDEDTRGGSTIEQQYVKN ***:::******:.*.**** *** **:** *: *******:****:** Mflv_1365|M.gilvum_PYR-GCK YQLLVIAQTDAEKRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL Mvan_5442|M.vanbaalenii_PYR-1 YQLLVIAQTDAEKRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL MSMEG_6201|M.smegmatis_MC2_155 YQLLVVAQTDAERRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL TH_2122|M.thermoresistible__bu YQLLVVAQTDAEKRAAIETTPARKLREIRMALTLDKTLTKPEILTRYLNL MUL_4257|M.ulcerans_Agy99 YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL MMAR_5171|M.marinum_M YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL Mb3707|M.bovis_AF2122/97 YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNL Rv3682|M.tuberculosis_H37Rv YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNL MAV_0446|M.avium_104 YQLLVTAKTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL MLBr_02308|M.leprae_Br4923 YQLLVTAQTDAEKRAAVETTPARKLREIRIALTLDKTFTKPEILTRYLNL MAB_0408c|M.abscessus_ATCC_199 YQLLVVAKTDAERKAAIETTPARKLREIRMALRLDQTFTKQEILTRYLNL ***** *:****::**:************:** **:*:** ********* Mflv_1365|M.gilvum_PYR-GCK VSFGNNAFGVQDAAQTYFGINATDLNWQQAALLAGMVQSTSTLNPYTNPD Mvan_5442|M.vanbaalenii_PYR-1 VSFGNNAFGVQDAAQTYFGVNASELNWQQAALLAGMVQSTSTLNPYTNPD MSMEG_6201|M.smegmatis_MC2_155 VSFGNGAYGIQDAAQTYFGVNASELNWQQAALLAGMVQSTSALNPYTNPD TH_2122|M.thermoresistible__bu VSFGNGAYGIQDAAQTYFGINASELDWHQAALLAGLVQSTTALNPYTNPD MUL_4257|M.ulcerans_Agy99 VSFGNNSFGVQDAAQTYFGINASELNWQQSALLAGMVQSTSTLNPYTNPD MMAR_5171|M.marinum_M VSFGNNSFGVQDAAQTYFGINASELNWQQSALLAGMVQSTSTLNPYTNPD Mb3707|M.bovis_AF2122/97 VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPD Rv3682|M.tuberculosis_H37Rv VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPD MAV_0446|M.avium_104 VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSALNPYTNPE MLBr_02308|M.leprae_Br4923 VSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYTNPE MAB_0408c|M.abscessus_ATCC_199 VSFGNNSFGVQDAAQTYFGVDAKDLNWQQAALLAGMVQSTSGLNPYVNPE *****.::*:*********::*.:*:*:*:*****:****: ****.**: Mflv_1365|M.gilvum_PYR-GCK GALARRNVVLDTMIENLPEYADELRAARQEPLGVLPQPKELPRGCIAAGD Mvan_5442|M.vanbaalenii_PYR-1 GALARRNVVLDTMIENLPEHADELRTAKQQPLGILPQPKELPRGCIAAGD MSMEG_6201|M.smegmatis_MC2_155 GALARRNLVLDTMIQNIPQEAEALRAAKEQPLGILPQPNELPRGCIAAGD TH_2122|M.thermoresistible__bu GALARRNLVLDTMIDQLPQEAEALRAAKEQPLGILPRPNELPRGCIAAGD MUL_4257|M.ulcerans_Agy99 GALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQPNELPRGCIAAGD MMAR_5171|M.marinum_M GALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQPNELPRGCIAAGD Mb3707|M.bovis_AF2122/97 GALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGD Rv3682|M.tuberculosis_H37Rv GALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGD MAV_0446|M.avium_104 GALARRNLVLDTMIENIPQEADALRAAKAAPLGILPQPNELPRGCIAAGD MLBr_02308|M.leprae_Br4923 GALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGD MAB_0408c|M.abscessus_ATCC_199 RALARRNLVLDTMIANSPDKKGELLAAKAQPLGVLPQPNELPRGCIAAGD ******:****** : * * :*: ***:**:*:*********** Mflv_1365|M.gilvum_PYR-GCK RAFFCDYALDYLARAGISKDQVAKGGYMIKTTLDPDVQASVKNAITQYAS Mvan_5442|M.vanbaalenii_PYR-1 RAFFCDYALDYLARAGISKDQVAKGGYLIKTTLEPDVQASVKNAINEFAS MSMEG_6201|M.smegmatis_MC2_155 RAFFCDYVLEYLARAGISKEQVAKGGYLIKTTLDPDVQSSVKSAIDSIAA TH_2122|M.thermoresistible__bu RAFFCDYVLEYLARAGISKEQVAKGGYLIKTTLDPEVQRAVKSAIDQYAR MUL_4257|M.ulcerans_Agy99 RAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFAS MMAR_5171|M.marinum_M RAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFAS Mb3707|M.bovis_AF2122/97 RAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYAS Rv3682|M.tuberculosis_H37Rv RAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYAS MAV_0446|M.avium_104 RAYFCDYVQEYLSRAGISKEQVARGGYLIKTTLDPDVQIPVKAAIDKFAS MLBr_02308|M.leprae_Br4923 RAFFCDYVQEYLSHAGISKDRLAKGGYLIRTTLDPNVQAPVKAAIDKFAS MAB_0408c|M.abscessus_ATCC_199 RAFFCDYVLDYLAKSGISKDQVMKGGYLIRTTLDPDVQNSVKQAVSHVAD **:****. :**:::****::: ***:*:***:*:** .** *: * Mflv_1365|M.gilvum_PYR-GCK PDLPGVASVMSVVKPGKDSHPVLAMASNRTYGLNLDAGETMQPQPFSLVG Mvan_5442|M.vanbaalenii_PYR-1 PDLPGVASVMSVIRPGKDSHPVLAMASNRTYGLNLDAGETMQPQPFSLVG MSMEG_6201|M.smegmatis_MC2_155 PDTPGVASVMSVIKPGKESHPVLAMASNRTYGLDTERGETMQPQPFSLVG TH_2122|M.thermoresistible__bu PDANGVASVMSVIRPGKESHPVLAMASSRHYGLNSEAGETMQPQPFSLVG MUL_4257|M.ulcerans_Agy99 PTLPGISSVMSVIKPGKESHQVLAMASNRAYGLDINAGETMRPQPFSLVG MMAR_5171|M.marinum_M PTLPGISSVMSVIKPGKESHQVLAMASNRKYGLDINAGETMRPQPFSLVG Mb3707|M.bovis_AF2122/97 PNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVG Rv3682|M.tuberculosis_H37Rv PNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVG MAV_0446|M.avium_104 PTLPGISSVMSVIQPGKTSHKVMAMASNRTYGLDVDAGQTMRPQPFSLVG MLBr_02308|M.leprae_Br4923 PNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVG MAB_0408c|M.abscessus_ATCC_199 PGLNGIANVMSVIKPGQTSHPILAMASSRTYGLDGNAFQTMQPQPFSLVG * *::.****: **: :* ::**.*.* ***: : :**:**.***** Mflv_1365|M.gilvum_PYR-GCK NGAGSVFKIFTTAAAMEMGMGINAQLDSPSRFEAKGLGSG-GARGCPPAT Mvan_5442|M.vanbaalenii_PYR-1 NGAGSVFKIFTTAAAMEMGMGINAQLDSPSRFEAKGLGSG-GARGCPPAT MSMEG_6201|M.smegmatis_MC2_155 NGAGSVFKIFTVAAAMEMGMGINTQLPVPARFEAKGLGSG-GARGCPPAT TH_2122|M.thermoresistible__bu HGAGSVFKIFTTAAAMEMGMGINTQLEAPAFFQAKGLGSS-DTPGCPAAT MUL_4257|M.ulcerans_Agy99 DGAGSIFKIFTTAAALDMGMGISAQLDVPGRFQGKGLGSG-GAKGCPKDT MMAR_5171|M.marinum_M DGAGSIFKIFTTAAALDMGMGINAQLDVPGRFQGKGLGSG-GAKGCPKDT Mb3707|M.bovis_AF2122/97 DGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSG-GAKGCPKET Rv3682|M.tuberculosis_H37Rv DGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSG-GAKGCPKET MAV_0446|M.avium_104 DGAGSVFKIFTTAAALDMGMGINATLEVPGRFQAKGMGSG-GAKGCPKDT MLBr_02308|M.leprae_Br4923 DGAGSVFKIFTTAAALDMGMGINAKLEVPSRFQAKGMGSG-GAKGCPKET MAB_0408c|M.abscessus_ATCC_199 DGAGSIFKIFTVAAAMDMGMGINTVLDVPPTFAAKGLGSSDGSKGCPKDN .****:*****.***::*****.: * * * .**:**. .: *** . Mflv_1365|M.gilvum_PYR-GCK WCVQNAGNYRGTMSVTDALATSPNTAFAKLIAQVGVQRTVDMAVRLGLRS Mvan_5442|M.vanbaalenii_PYR-1 WCVQNAGNYRGTMNVTDALATSPNTAFAKLIAQVGVQRTVDMAVKLGLRS MSMEG_6201|M.smegmatis_MC2_155 WCVQNAGGYRGSMSVTDALATSPNTAFAKLISQIGVQRAVDMAVRLGLRS TH_2122|M.thermoresistible__bu WCVRNAGSYRGSMNVTDALATSPNTAFAKLISQIGVPRTVDMAVRLGLRS MUL_4257|M.ulcerans_Agy99 WCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGLRS MMAR_5171|M.marinum_M WCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGLRS Mb3707|M.bovis_AF2122/97 WCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRS Rv3682|M.tuberculosis_H37Rv WCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRS MAV_0446|M.avium_104 WCVVNAGNYKGSMNVTEALATSPNTAFAKLIQQVGVTRTVDMAIKLGLRS MLBr_02308|M.leprae_Br4923 WCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVARTVDMAIKLGLRS MAB_0408c|M.abscessus_ATCC_199 WCVKNVGNYRSPMSVTDALATSPNTAFAKLIQSIGVSKAVDMAVKLGMRS *** *.*.*:..*.**:************** .:** ::****::**:** Mflv_1365|M.gilvum_PYR-GCK YALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA Mvan_5442|M.vanbaalenii_PYR-1 YALPGTARDYDPESNESLADFVKRQNLGSFTLGPIEVNALELSNVAATLA MSMEG_6201|M.smegmatis_MC2_155 YAQPGTARDYDPESSESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA TH_2122|M.thermoresistible__bu YAQPGTARDYDPNSDESIADWVKRQNIGSFTLGPIEVNALELSNVAATLA MUL_4257|M.ulcerans_Agy99 YANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA MMAR_5171|M.marinum_M YANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA Mb3707|M.bovis_AF2122/97 YANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLA Rv3682|M.tuberculosis_H37Rv YANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLA MAV_0446|M.avium_104 YADPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA MLBr_02308|M.leprae_Br4923 YTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLA MAB_0408c|M.abscessus_ATCC_199 YAEPGTAKPYDPEGDESLAEYIKKYNLGSFTLGPIQINPLELSNVAATLA *: ****: *:*:..**:*:::*: *:********::*.*********** Mflv_1365|M.gilvum_PYR-GCK SGGMWCPPNPIAEVYDRYGEPVSVTTETCEQAVPEGLANTLANAMSKDDT Mvan_5442|M.vanbaalenii_PYR-1 SGGMWCPPNPIAEVRDRYGELVSVTTETCEQVVPEGLANTLAVAMSKDDT MSMEG_6201|M.smegmatis_MC2_155 SGGTWCPPNPIAQVVDRNGNEVAVTTETCEQVVPEGLANTLANAMSKDDT TH_2122|M.thermoresistible__bu SGGVWCPPNPIDKVYDRHGNEVSVTTETCEQVVPEGLANTLANAMSEDDR MUL_4257|M.ulcerans_Agy99 SGGVWCPPNPVDKLIDRNGNEVAVTTETCDQVVPEGLANTLANAMSKDAV MMAR_5171|M.marinum_M SGGVWCPPNPVDKLIDRNGNEVAVTTETCDQVVPEGLANTLANAMSKDAV Mb3707|M.bovis_AF2122/97 SGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAV Rv3682|M.tuberculosis_H37Rv SGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAV MAV_0446|M.avium_104 SGGTWCPPNPIDKLIDRKGNEVAVTTETCDQVVPEGLANTMANAMSKDAV MLBr_02308|M.leprae_Br4923 SGGMWCPPNPIDKLFDRNGNEVAVTVETCDRVVPEGLANTLANAMSKDTK MAB_0408c|M.abscessus_ATCC_199 SGGKWCPPNPIDKVFDRHGKEVPTTVEACEQVVPTGLANTLANALSKDDQ *** ******: :: ** *: *..*.*:*::.** *****:* *:*:* Mflv_1365|M.gilvum_PYR-GCK GAGTAAGAAGSVGWNLPMSGKTGTTEANRSSAFLGFTNRYAAASYIYDDS Mvan_5442|M.vanbaalenii_PYR-1 GAGTAAGAAGSTGWSLPMSGKTGTTESNRSSAFLGFTNQYAAASYIYDDS MSMEG_6201|M.smegmatis_MC2_155 GSGTAAASAGSVGWNLPMSGKTGTTEDNRSSAFLGFTNQYAAANYIYDDS TH_2122|M.thermoresistible__bu GAGTAAGAAASVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYDDS MUL_4257|M.ulcerans_Agy99 GGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS MMAR_5171|M.marinum_M GGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS Mb3707|M.bovis_AF2122/97 GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS Rv3682|M.tuberculosis_H37Rv GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS MAV_0446|M.avium_104 GGGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDS MLBr_02308|M.leprae_Br4923 GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDS MAB_0408c|M.abscessus_ATCC_199 PGGTAAGSAGSVGWNLPLSSKTGTTEAHRSSAFLGYTNNLAGASYIYDDS .***:.:*.:.**.**:*.****** :**:.*:*:**. *.*.****** Mflv_1365|M.gilvum_PYR-GCK TAPTELCSFPLRQCGSGNLFGGNEPARTWFSAMQPIATAFGDVTLPPTDP Mvan_5442|M.vanbaalenii_PYR-1 TAPTELCSFPLRQCGSGNLFGGNEPARTWFTAMTPIATAFGDVTLPPTDP MSMEG_6201|M.smegmatis_MC2_155 PNPSELCSFPLRQCGSGNLFGGNEPARTWFTAMKPIAESFGPVALPPTDP TH_2122|M.thermoresistible__bu NSPGELCSFPLRRCGSGDLFGGNEPARTWFAAMKPIAEKFGPVALPPTDP MUL_4257|M.ulcerans_Agy99 TNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDP MMAR_5171|M.marinum_M TNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDP Mb3707|M.bovis_AF2122/97 SSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDP Rv3682|M.tuberculosis_H37Rv SSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDP MAV_0446|M.avium_104 PNPTDLCSAPLRHCGEGDLYGGNEPARTWFTAMKPIATNFGPVQLPPTDP MLBr_02308|M.leprae_Br4923 TSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDP MAB_0408c|M.abscessus_ATCC_199 TTPGDLCSFPLRKCGDGNLYGGNEPARAWFEAMKPIADNYGPTVLPPTEP * :*** ***:*..*:*:*****:*:** *: *** :* . ****:* Mflv_1365|M.gilvum_PYR-GCK RYVEGAPGSKVPSVAGMDQDTARARLREAGFQVADQATPVNSSSRYGTVV Mvan_5442|M.vanbaalenii_PYR-1 RYVDGAPGSKVPSVAGMNQDTARQRLREAGFQVADQPTPVNSTAPYGAVV MSMEG_6201|M.smegmatis_MC2_155 RYVDGGPGSRVPSVSGLTEEAARQRLKEAGFQVADQASYVNSGARSGTVV TH_2122|M.thermoresistible__bu RYVDGGPGSRVPSVSGLSEEAARQRLRDAGFQVADGVATVNSSARRGTVV MUL_4257|M.ulcerans_Agy99 RYVDGAPGSRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEAV MMAR_5171|M.marinum_M RYVDGAPGSRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEVV Mb3707|M.bovis_AF2122/97 RYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVV Rv3682|M.tuberculosis_H37Rv RYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVV MAV_0446|M.avium_104 RYVDGAPGSRVPSVAGLDIDAARQRIKEAGFQVADQNNFVNSSAKQGEVV MLBr_02308|M.leprae_Br4923 RYVDGSPGSQVPSVTGLDLDAARQRLKGAGFQVADQPTLINSTAKLGAVV MAB_0408c|M.abscessus_ATCC_199 RYVEGGPGSKVPSINGLREPEARDVLKKAGFRVADQASSVNSTAPFNEVV ***:*.***:***: *: ** :: ***:*** :** : . .* Mflv_1365|M.gilvum_PYR-GCK GTAPSGQTVPGSIVTIQISNGIAPAPPPPPAG--APPPGGPP-------- Mvan_5442|M.vanbaalenii_PYR-1 GTSPTGQTVPGSIITIQISNGIAPPPPPPPPG--APP-GLPP-------- MSMEG_6201|M.smegmatis_MC2_155 GTTPSGQTIPGSIITIQLSNGIPPPPPPPVN--IPLPGGP---------- TH_2122|M.thermoresistible__bu GTNPSGQTIPXXYPTQFLRADLDALGVIPADKLLEVPDGTRILIAGAVTH MUL_4257|M.ulcerans_Agy99 GTSPSGQTIPGSIITIQISNGIPPAPPPPP---EGEPPPP---------- MMAR_5171|M.marinum_M GTSPSGQTIPGSIITIQISNGIPPAPPPPP---EGEPPPP---------- Mb3707|M.bovis_AF2122/97 GTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPP---------- Rv3682|M.tuberculosis_H37Rv GTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPP---------- MAV_0446|M.avium_104 GTTPSGATIPGSIITIQVSNGIPPAPPPPP----EGAPPP---------- MLBr_02308|M.leprae_Br4923 GTTPSGQTIPGSIITIQTSSGIPPAPPPPP---EGGPPMPPS-------- MAB_0408c|M.abscessus_ATCC_199 GTSPSGTTIPGSVITILMSNGIPPAPPPLVIPGIPGAPPG---------- ** *:* *:* * .: . . Mflv_1365|M.gilvum_PYR-GCK ---PPAGETVIQIPGLPPIT--VPVLGPPP--------PPPPPPG----- Mvan_5442|M.vanbaalenii_PYR-1 ---PPVGQTVIQIPGLPPIT--VPVLGPPP--------PPPPPPG----- MSMEG_6201|M.smegmatis_MC2_155 ---PEIGQTVVEIPGLPPIT--VPVLGPP---------PPPPPP------ TH_2122|M.thermoresistible__bu RQRPATAQGVTFLN-LEDETGMVNVLCSPGVWARHRRLAQTAPALLVRGI MUL_4257|M.ulcerans_Agy99 -----VGSQVVEIPGLPPIT--IPLLAPPP-------P------------ MMAR_5171|M.marinum_M -----VGSQVVEIPGLPPIT--IPLLAPPP-------P------------ Mb3707|M.bovis_AF2122/97 -----VGSQVVEIPGLPPIT--IPLLAPPP-------PAP--PP------ Rv3682|M.tuberculosis_H37Rv -----VGSQVVEIPGLPPIT--IPLLAPPP-------PAP--PP------ MAV_0446|M.avium_104 -----VGSQVVEIPGLPPIT--IPLLAPPP-------PAPGQPPP----- MLBr_02308|M.leprae_Br4923 -----VGSQVIEIPGLPPIT--IPLLAPP--------------------- MAB_0408c|M.abscessus_ATCC_199 ----EMTTTIVNIPGLPPIT--VPVLAPPP-------------------- : : * * : :* .* Mflv_1365|M.gilvum_PYR-GCK ------------------------------ Mvan_5442|M.vanbaalenii_PYR-1 ------------------------------ MSMEG_6201|M.smegmatis_MC2_155 ------------------------------ TH_2122|M.thermoresistible__bu VQNATGAVTVVADRMRRLELRVGSRSRDFR MUL_4257|M.ulcerans_Agy99 ------------------------------ MMAR_5171|M.marinum_M ------------------------------ Mb3707|M.bovis_AF2122/97 ------------------------------ Rv3682|M.tuberculosis_H37Rv ------------------------------ MAV_0446|M.avium_104 ------------------------------ MLBr_02308|M.leprae_Br4923 ------------------------------ MAB_0408c|M.abscessus_ATCC_199 ------------------------------