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M. bovis AF2122 / 97 Mb3707 (ponA2)

annotation: bifunctional membrane-associated penicillin-binding protein 1A/1B
coordinates: 4059263 - 4061695
length: 810

MPERLPAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRASEVVANGSAQLLEGQVPAVSTMVDAKG
NTIAWLYSQRRFEVPSDKIANTMKLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQY
VKNYQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNLVSFGNNSFGVQDAAQTY
FGINASDLNWQQAALLAGMVQSTSTLNPYTNPDGALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQ
PNELPRGCIAAGDRAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYASPNLAGIS
SVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVGDGAGSIFKIFTTAAALDMGMGINAQLD
VPPRFQAKGLGSGGAKGCPKETWCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGL
RSYANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLASGGVWCPPNPIDQLIDRN
GNEVAVTTETCDQVVPAGLANTLANAMSKDAVGSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTN
RYAAANYIYDDSSSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDPRYVDGAPG
SRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVVGTSPSGQTIPGSIVTIQISNGIPPAPPP
PPLPEDGGPPPPVGSQVVEIPGLPPITIPLLAPPPPAPPP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3707ponA2-100% (810)bifunctional membrane-associated penicillin-binding protein 1A/1B
M. bovis AF2122 / 97Mb0051ponA11e-5126.39% (739) bifunctional penicillin-binding protein 1A/1B
M. bovis AF2122 / 97Mb0016cpbpA1e-0924.06% (320) penicillin-binding protein PbpA

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_1365-0.080.27% (811) glycosyl transferase family protein
M. tuberculosis H37RvRv3682ponA20.0100.00% (810) bifunctional membrane-associated penicillin-binding protein
M. leprae Br4923MLBr_02308pon10.087.59% (806) penicillin binding protein (class A)
M. abscessus ATCC 19977MAB_0408c-0.072.38% (811) bifunctional membrane-associated penicillin-binding protein
M. marinum MMMAR_5171ponA20.091.19% (806) bifunctional membrane-associated penicillin- binding
M. avium 104MAV_0446-0.089.35% (789) transglycosylase
M. smegmatis MC2 155MSMEG_6201-0.080.91% (791) transglycosylase
M. thermoresistible (build 8)TH_2122ponA0.078.97% (756) PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING
M. ulcerans Agy99MUL_4257ponA20.090.69% (806) bifunctional membrane-associated penicillin- binding
M. vanbaalenii PYR-1Mvan_5442-0.080.52% (806) glycosyl transferase family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1365|M.gilvum_PYR-GCK          MPEQPPTQP---PRAVTVIKLAWCVVLASVIVAGLLFPVVGGFGLVSNRA
Mvan_5442|M.vanbaalenii_PYR-1       MPEHPSGPP---PRAVTVIKLAWCVLLASVVAAGLMFPVVGGFGLMPNRA
MSMEG_6201|M.smegmatis_MC2_155      -----------------------------MLAAALMFPVVGGFGLMSNRA
TH_2122|M.thermoresistible__bu      MPEDPPTAPTESTRAATVIKLAWCCLLAAVIAAALMFPVVGGIGLLSNRA
Mb3707|M.bovis_AF2122/97            MPERL-------PAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRA
Rv3682|M.tuberculosis_H37Rv         MPERL-------PAAITVLKLAGCCLLASVVATALTFPFAGGLGLMSNRA
MMAR_5171|M.marinum_M               MSERP-------PAALTLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRA
MUL_4257|M.ulcerans_Agy99           MSERP-------PAALSLLKLSGFCLLASIVAAALMFPFAGGIGLMSNRA
MAV_0446|M.avium_104                ------------------------------MATALLFPVAGGIGLVSNRA
MLBr_02308|M.leprae_Br4923          MSERL-------PAVLAVLKLAGYCLLAGVVTTAMMFPLAGGLGVISNRA
MAB_0408c|M.abscessus_ATCC_199      MPERLSP---QIPPSVTLAKLAGCGLVAAVILAGLMFPFAGGFGLASNRA
                                                                  : :.: **..**:*: .***

Mflv_1365|M.gilvum_PYR-GCK          SDVVANGSAQLVEGEVPQVSTMTDSKGNIIAWLYSQRRFEVPSDQIANTM
Mvan_5442|M.vanbaalenii_PYR-1       SDVVANGSAQLVEGEVPQVSTMTDAKGNVIAWLYNQRRFEVPSDQIANTM
MSMEG_6201|M.smegmatis_MC2_155      SDVVANGSAALVEGEVPQVSTMVDAKGNTIAWLYSQRRFEVPSEQIANTM
TH_2122|M.thermoresistible__bu      SDVVANGSAQLVEGDVPAVSTMVDAEGNPIAWLYSQRRWEVPSEEIADTM
Mb3707|M.bovis_AF2122/97            SEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
Rv3682|M.tuberculosis_H37Rv         SEVVANGSAQLLEGQVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MMAR_5171|M.marinum_M               SEVVANGSAQLLQGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MUL_4257|M.ulcerans_Agy99           SEVVANGSAQLLQGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MAV_0446|M.avium_104                SEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPSDKIANTM
MLBr_02308|M.leprae_Br4923          SEVVANGSAQLLEGEVPAVSTMVDAKGNTIAWLYSQRRFEVPTDKIANTM
MAB_0408c|M.abscessus_ATCC_199      SDVVANGSTQLLQGEVPAVTTVEDAKGNKIAYLYTQRRFEVSADEIADTM
                                    *:******: *::*:** *:*: *::** **:**.***:**.:::**:**

Mflv_1365|M.gilvum_PYR-GCK          KLAIVSIEDKRFADHNGVDWQGTLTGLSGYLSGNLDTRGGSTIEQQYVKN
Mvan_5442|M.vanbaalenii_PYR-1       KLAIVSIEDKRFADHNGVDWQGTLTGLSGYLSGNLDTRGGSTIEQQYVKN
MSMEG_6201|M.smegmatis_MC2_155      KLAIVSIEDKRFAEHNGVDWQGTLTGLSGYLSGNPDTRGGSTIEQQYVKN
TH_2122|M.thermoresistible__bu      KLAIVAIEDKRFAEHNGVDWQGTLTGLTGYLRGDSDTRGGSTLEQQYVKN
Mb3707|M.bovis_AF2122/97            KLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKN
Rv3682|M.tuberculosis_H37Rv         KLAIVSIEDKRFADHSGVDWKGTLTGLAGYASGDLDTRGGSTLEQQYVKN
MMAR_5171|M.marinum_M               KLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQYIKN
MUL_4257|M.ulcerans_Agy99           KLAIVSIEDKRFAEHNGVDWKGTLTGLAGYASGDLDTRGGSTIEQQYIKN
MAV_0446|M.avium_104                KLAIVSIEDKRFADHNGVDWKGTLTGLAGYARGDVDTRGGSTIEQQYIKN
MLBr_02308|M.leprae_Br4923          KLAIVSIEDKRFTDHNGVDWPGTLTGLAGYASGDVDTRGGSTIEQQYVKN
MAB_0408c|M.abscessus_ATCC_199      KLALLSIEDKRFTSHNGVDWKGTLGGLAGYASGDEDTRGGSTIEQQYVKN
                                    ***:::******:.*.**** *** **:**  *: *******:****:**

Mflv_1365|M.gilvum_PYR-GCK          YQLLVIAQTDAEKRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL
Mvan_5442|M.vanbaalenii_PYR-1       YQLLVIAQTDAEKRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MSMEG_6201|M.smegmatis_MC2_155      YQLLVVAQTDAERRAAIETTPARKLREIRMALTLDKTFTKPEILTRYLNL
TH_2122|M.thermoresistible__bu      YQLLVVAQTDAEKRAAIETTPARKLREIRMALTLDKTLTKPEILTRYLNL
Mb3707|M.bovis_AF2122/97            YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNL
Rv3682|M.tuberculosis_H37Rv         YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKSEILTRYLNL
MMAR_5171|M.marinum_M               YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MUL_4257|M.ulcerans_Agy99           YQLLVTAQTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MAV_0446|M.avium_104                YQLLVTAKTDAEKRAAVETTPARKLREIRMALTLDKTFTKPEILTRYLNL
MLBr_02308|M.leprae_Br4923          YQLLVTAQTDAEKRAAVETTPARKLREIRIALTLDKTFTKPEILTRYLNL
MAB_0408c|M.abscessus_ATCC_199      YQLLVVAKTDAERKAAIETTPARKLREIRMALRLDQTFTKQEILTRYLNL
                                    ***** *:****::**:************:** **:*:** *********

Mflv_1365|M.gilvum_PYR-GCK          VSFGNNAFGVQDAAQTYFGINATDLNWQQAALLAGMVQSTSTLNPYTNPD
Mvan_5442|M.vanbaalenii_PYR-1       VSFGNNAFGVQDAAQTYFGVNASELNWQQAALLAGMVQSTSTLNPYTNPD
MSMEG_6201|M.smegmatis_MC2_155      VSFGNGAYGIQDAAQTYFGVNASELNWQQAALLAGMVQSTSALNPYTNPD
TH_2122|M.thermoresistible__bu      VSFGNGAYGIQDAAQTYFGINASELDWHQAALLAGLVQSTTALNPYTNPD
Mb3707|M.bovis_AF2122/97            VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPD
Rv3682|M.tuberculosis_H37Rv         VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSTLNPYTNPD
MMAR_5171|M.marinum_M               VSFGNNSFGVQDAAQTYFGINASELNWQQSALLAGMVQSTSTLNPYTNPD
MUL_4257|M.ulcerans_Agy99           VSFGNNSFGVQDAAQTYFGINASELNWQQSALLAGMVQSTSTLNPYTNPD
MAV_0446|M.avium_104                VSFGNNSFGVQDAAQTYFGINASDLNWQQAALLAGMVQSTSALNPYTNPE
MLBr_02308|M.leprae_Br4923          VSFGNNSFGVQDAAQTYFGVNASDLNWQQAALLAGMVQSTSTLNPYTNPE
MAB_0408c|M.abscessus_ATCC_199      VSFGNNSFGVQDAAQTYFGVDAKDLNWQQAALLAGMVQSTSGLNPYVNPE
                                    *****.::*:*********::*.:*:*:*:*****:****: ****.**:

Mflv_1365|M.gilvum_PYR-GCK          GALARRNVVLDTMIENLPEYADELRAARQEPLGVLPQPKELPRGCIAAGD
Mvan_5442|M.vanbaalenii_PYR-1       GALARRNVVLDTMIENLPEHADELRTAKQQPLGILPQPKELPRGCIAAGD
MSMEG_6201|M.smegmatis_MC2_155      GALARRNLVLDTMIQNIPQEAEALRAAKEQPLGILPQPNELPRGCIAAGD
TH_2122|M.thermoresistible__bu      GALARRNLVLDTMIDQLPQEAEALRAAKEQPLGILPRPNELPRGCIAAGD
Mb3707|M.bovis_AF2122/97            GALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGD
Rv3682|M.tuberculosis_H37Rv         GALARRNVVLDTMIENLPGEAEALRAAKAEPLGVLPQPNELPRGCIAAGD
MMAR_5171|M.marinum_M               GALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQPNELPRGCIAAGD
MUL_4257|M.ulcerans_Agy99           GALARRNLVLDTMIQNIPSEADALRAAKAEPLGILPQPNELPRGCIAAGD
MAV_0446|M.avium_104                GALARRNLVLDTMIENIPQEADALRAAKAAPLGILPQPNELPRGCIAAGD
MLBr_02308|M.leprae_Br4923          GALARRNLVLDTMIENLPQDAEALRAAKTEPLGILPRPNELPRGCIAAGD
MAB_0408c|M.abscessus_ATCC_199      RALARRNLVLDTMIANSPDKKGELLAAKAQPLGVLPQPNELPRGCIAAGD
                                     ******:****** : *     * :*:  ***:**:*:***********

Mflv_1365|M.gilvum_PYR-GCK          RAFFCDYALDYLARAGISKDQVAKGGYMIKTTLDPDVQASVKNAITQYAS
Mvan_5442|M.vanbaalenii_PYR-1       RAFFCDYALDYLARAGISKDQVAKGGYLIKTTLEPDVQASVKNAINEFAS
MSMEG_6201|M.smegmatis_MC2_155      RAFFCDYVLEYLARAGISKEQVAKGGYLIKTTLDPDVQSSVKSAIDSIAA
TH_2122|M.thermoresistible__bu      RAFFCDYVLEYLARAGISKEQVAKGGYLIKTTLDPEVQRAVKSAIDQYAR
Mb3707|M.bovis_AF2122/97            RAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYAS
Rv3682|M.tuberculosis_H37Rv         RAFFCDYVQEYLSRAGISKEQVATGGYLIRTTLDPEVQAPVKAAIDKYAS
MMAR_5171|M.marinum_M               RAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFAS
MUL_4257|M.ulcerans_Agy99           RAFFCDYVQEYLSRAGISKEQLARGGYLIRTTLDPDVQVPVKAAIDKFAS
MAV_0446|M.avium_104                RAYFCDYVQEYLSRAGISKEQVARGGYLIKTTLDPDVQIPVKAAIDKFAS
MLBr_02308|M.leprae_Br4923          RAFFCDYVQEYLSHAGISKDRLAKGGYLIRTTLDPNVQAPVKAAIDKFAS
MAB_0408c|M.abscessus_ATCC_199      RAFFCDYVLDYLAKSGISKDQVMKGGYLIRTTLDPDVQNSVKQAVSHVAD
                                    **:****. :**:::****:::  ***:*:***:*:** .** *:   * 

Mflv_1365|M.gilvum_PYR-GCK          PDLPGVASVMSVVKPGKDSHPVLAMASNRTYGLNLDAGETMQPQPFSLVG
Mvan_5442|M.vanbaalenii_PYR-1       PDLPGVASVMSVIRPGKDSHPVLAMASNRTYGLNLDAGETMQPQPFSLVG
MSMEG_6201|M.smegmatis_MC2_155      PDTPGVASVMSVIKPGKESHPVLAMASNRTYGLDTERGETMQPQPFSLVG
TH_2122|M.thermoresistible__bu      PDANGVASVMSVIRPGKESHPVLAMASSRHYGLNSEAGETMQPQPFSLVG
Mb3707|M.bovis_AF2122/97            PNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVG
Rv3682|M.tuberculosis_H37Rv         PNLAGISSVMSVIKPGKDAHKVLAMASNRKYGLDLEAGETMRPQPFSLVG
MMAR_5171|M.marinum_M               PTLPGISSVMSVIKPGKESHQVLAMASNRKYGLDINAGETMRPQPFSLVG
MUL_4257|M.ulcerans_Agy99           PTLPGISSVMSVIKPGKESHQVLAMASNRAYGLDINAGETMRPQPFSLVG
MAV_0446|M.avium_104                PTLPGISSVMSVIQPGKTSHKVMAMASNRTYGLDVDAGQTMRPQPFSLVG
MLBr_02308|M.leprae_Br4923          PNLAGISSVMSVITPGKDAHRVIAMGSNRRYGLDTEAGETMRPQTFSLVG
MAB_0408c|M.abscessus_ATCC_199      PGLNGIANVMSVIKPGQTSHPILAMASSRTYGLDGNAFQTMQPQPFSLVG
                                    *   *::.****: **: :* ::**.*.* ***: :  :**:**.*****

Mflv_1365|M.gilvum_PYR-GCK          NGAGSVFKIFTTAAAMEMGMGINAQLDSPSRFEAKGLGSG-GARGCPPAT
Mvan_5442|M.vanbaalenii_PYR-1       NGAGSVFKIFTTAAAMEMGMGINAQLDSPSRFEAKGLGSG-GARGCPPAT
MSMEG_6201|M.smegmatis_MC2_155      NGAGSVFKIFTVAAAMEMGMGINTQLPVPARFEAKGLGSG-GARGCPPAT
TH_2122|M.thermoresistible__bu      HGAGSVFKIFTTAAAMEMGMGINTQLEAPAFFQAKGLGSS-DTPGCPAAT
Mb3707|M.bovis_AF2122/97            DGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSG-GAKGCPKET
Rv3682|M.tuberculosis_H37Rv         DGAGSIFKIFTTAAALDMGMGINAQLDVPPRFQAKGLGSG-GAKGCPKET
MMAR_5171|M.marinum_M               DGAGSIFKIFTTAAALDMGMGINAQLDVPGRFQGKGLGSG-GAKGCPKDT
MUL_4257|M.ulcerans_Agy99           DGAGSIFKIFTTAAALDMGMGISAQLDVPGRFQGKGLGSG-GAKGCPKDT
MAV_0446|M.avium_104                DGAGSVFKIFTTAAALDMGMGINATLEVPGRFQAKGMGSG-GAKGCPKDT
MLBr_02308|M.leprae_Br4923          DGAGSVFKIFTTAAALDMGMGINAKLEVPSRFQAKGMGSG-GAKGCPKET
MAB_0408c|M.abscessus_ATCC_199      DGAGSIFKIFTVAAAMDMGMGINTVLDVPPTFAAKGLGSSDGSKGCPKDN
                                    .****:*****.***::*****.: *  *  * .**:**. .: ***  .

Mflv_1365|M.gilvum_PYR-GCK          WCVQNAGNYRGTMSVTDALATSPNTAFAKLIAQVGVQRTVDMAVRLGLRS
Mvan_5442|M.vanbaalenii_PYR-1       WCVQNAGNYRGTMNVTDALATSPNTAFAKLIAQVGVQRTVDMAVKLGLRS
MSMEG_6201|M.smegmatis_MC2_155      WCVQNAGGYRGSMSVTDALATSPNTAFAKLISQIGVQRAVDMAVRLGLRS
TH_2122|M.thermoresistible__bu      WCVRNAGSYRGSMNVTDALATSPNTAFAKLISQIGVPRTVDMAVRLGLRS
Mb3707|M.bovis_AF2122/97            WCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRS
Rv3682|M.tuberculosis_H37Rv         WCVVNAGNYRGSMNVTDALATSPNTAFAKLISQVGVGRAVDMAIKLGLRS
MMAR_5171|M.marinum_M               WCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGLRS
MUL_4257|M.ulcerans_Agy99           WCVINAGNYRGSMSVTDALATSPNTAFAKLISQVGVSRTVDMAIKLGLRS
MAV_0446|M.avium_104                WCVVNAGNYKGSMNVTEALATSPNTAFAKLIQQVGVTRTVDMAIKLGLRS
MLBr_02308|M.leprae_Br4923          WCVINAGNYRGSMNVTDALATSPNTAFAKLIQQVGVARTVDMAIKLGLRS
MAB_0408c|M.abscessus_ATCC_199      WCVKNVGNYRSPMSVTDALATSPNTAFAKLIQSIGVSKAVDMAVKLGMRS
                                    *** *.*.*:..*.**:************** .:** ::****::**:**

Mflv_1365|M.gilvum_PYR-GCK          YALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
Mvan_5442|M.vanbaalenii_PYR-1       YALPGTARDYDPESNESLADFVKRQNLGSFTLGPIEVNALELSNVAATLA
MSMEG_6201|M.smegmatis_MC2_155      YAQPGTARDYDPESSESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
TH_2122|M.thermoresistible__bu      YAQPGTARDYDPNSDESIADWVKRQNIGSFTLGPIEVNALELSNVAATLA
Mb3707|M.bovis_AF2122/97            YANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLA
Rv3682|M.tuberculosis_H37Rv         YANPGTARDYNPDSNESLADFVKRQNLGSFTLGPIELNALELSNVAATLA
MMAR_5171|M.marinum_M               YANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
MUL_4257|M.ulcerans_Agy99           YANPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
MAV_0446|M.avium_104                YADPGTARDYNPDSNESLADFVKRQNIGSFTLGPIEVNALELSNVAATLA
MLBr_02308|M.leprae_Br4923          YTTPGTARDYNPDSNESLADFVKRQNIGSFTLGPIKVNALELSNVAATLA
MAB_0408c|M.abscessus_ATCC_199      YAEPGTAKPYDPEGDESLAEYIKKYNLGSFTLGPIQINPLELSNVAATLA
                                    *: ****: *:*:..**:*:::*: *:********::*.***********

Mflv_1365|M.gilvum_PYR-GCK          SGGMWCPPNPIAEVYDRYGEPVSVTTETCEQAVPEGLANTLANAMSKDDT
Mvan_5442|M.vanbaalenii_PYR-1       SGGMWCPPNPIAEVRDRYGELVSVTTETCEQVVPEGLANTLAVAMSKDDT
MSMEG_6201|M.smegmatis_MC2_155      SGGTWCPPNPIAQVVDRNGNEVAVTTETCEQVVPEGLANTLANAMSKDDT
TH_2122|M.thermoresistible__bu      SGGVWCPPNPIDKVYDRHGNEVSVTTETCEQVVPEGLANTLANAMSEDDR
Mb3707|M.bovis_AF2122/97            SGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAV
Rv3682|M.tuberculosis_H37Rv         SGGVWCPPNPIDQLIDRNGNEVAVTTETCDQVVPAGLANTLANAMSKDAV
MMAR_5171|M.marinum_M               SGGVWCPPNPVDKLIDRNGNEVAVTTETCDQVVPEGLANTLANAMSKDAV
MUL_4257|M.ulcerans_Agy99           SGGVWCPPNPVDKLIDRNGNEVAVTTETCDQVVPEGLANTLANAMSKDAV
MAV_0446|M.avium_104                SGGTWCPPNPIDKLIDRKGNEVAVTTETCDQVVPEGLANTMANAMSKDAV
MLBr_02308|M.leprae_Br4923          SGGMWCPPNPIDKLFDRNGNEVAVTVETCDRVVPEGLANTLANAMSKDTK
MAB_0408c|M.abscessus_ATCC_199      SGGKWCPPNPIDKVFDRHGKEVPTTVEACEQVVPTGLANTLANALSKDDQ
                                    *** ******: :: ** *: *..*.*:*::.** *****:* *:*:*  

Mflv_1365|M.gilvum_PYR-GCK          GAGTAAGAAGSVGWNLPMSGKTGTTEANRSSAFLGFTNRYAAASYIYDDS
Mvan_5442|M.vanbaalenii_PYR-1       GAGTAAGAAGSTGWSLPMSGKTGTTESNRSSAFLGFTNQYAAASYIYDDS
MSMEG_6201|M.smegmatis_MC2_155      GSGTAAASAGSVGWNLPMSGKTGTTEDNRSSAFLGFTNQYAAANYIYDDS
TH_2122|M.thermoresistible__bu      GAGTAAGAAASVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYDDS
Mb3707|M.bovis_AF2122/97            GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
Rv3682|M.tuberculosis_H37Rv         GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
MMAR_5171|M.marinum_M               GGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
MUL_4257|M.ulcerans_Agy99           GGGTASGSAGAAGWSLPVSGKTGTTEAHRSAGFVGFTNRYAAANYIYDDS
MAV_0446|M.avium_104                GGGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDS
MLBr_02308|M.leprae_Br4923          GSGTAAGSAGAAGWDLPMSGKTGTTEAHRSSGFVGFTNHYAAANYIYDDS
MAB_0408c|M.abscessus_ATCC_199      PGGTAAGSAGSVGWNLPLSSKTGTTEAHRSSAFLGYTNNLAGASYIYDDS
                                     .***:.:*.:.**.**:*.****** :**:.*:*:**. *.*.******

Mflv_1365|M.gilvum_PYR-GCK          TAPTELCSFPLRQCGSGNLFGGNEPARTWFSAMQPIATAFGDVTLPPTDP
Mvan_5442|M.vanbaalenii_PYR-1       TAPTELCSFPLRQCGSGNLFGGNEPARTWFTAMTPIATAFGDVTLPPTDP
MSMEG_6201|M.smegmatis_MC2_155      PNPSELCSFPLRQCGSGNLFGGNEPARTWFTAMKPIAESFGPVALPPTDP
TH_2122|M.thermoresistible__bu      NSPGELCSFPLRRCGSGDLFGGNEPARTWFAAMKPIAEKFGPVALPPTDP
Mb3707|M.bovis_AF2122/97            SSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDP
Rv3682|M.tuberculosis_H37Rv         SSPTDLCSGPLRHCGSGDLYGGNEPSRTWFAAMKPIANNFGEVQLPPTDP
MMAR_5171|M.marinum_M               TNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDP
MUL_4257|M.ulcerans_Agy99           TNPTDLCSGPLRHCGNGDLYGGNEPARTWFTALKPIATDFGEVQLPPTDP
MAV_0446|M.avium_104                PNPTDLCSAPLRHCGEGDLYGGNEPARTWFTAMKPIATNFGPVQLPPTDP
MLBr_02308|M.leprae_Br4923          TSPTNLCSGPLRHCSNGDLYGGNEPARTWFTAMKPIATKFGEVRLPPTDP
MAB_0408c|M.abscessus_ATCC_199      TTPGDLCSFPLRKCGDGNLYGGNEPARAWFEAMKPIADNYGPTVLPPTEP
                                      * :*** ***:*..*:*:*****:*:** *: ***  :* . ****:*

Mflv_1365|M.gilvum_PYR-GCK          RYVEGAPGSKVPSVAGMDQDTARARLREAGFQVADQATPVNSSSRYGTVV
Mvan_5442|M.vanbaalenii_PYR-1       RYVDGAPGSKVPSVAGMNQDTARQRLREAGFQVADQPTPVNSTAPYGAVV
MSMEG_6201|M.smegmatis_MC2_155      RYVDGGPGSRVPSVSGLTEEAARQRLKEAGFQVADQASYVNSGARSGTVV
TH_2122|M.thermoresistible__bu      RYVDGGPGSRVPSVSGLSEEAARQRLRDAGFQVADGVATVNSSARRGTVV
Mb3707|M.bovis_AF2122/97            RYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVV
Rv3682|M.tuberculosis_H37Rv         RYVDGAPGSRVPSVAGLDVDAARQRLKDAGFQVADQTNSVNSSAKYGEVV
MMAR_5171|M.marinum_M               RYVDGAPGSRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEVV
MUL_4257|M.ulcerans_Agy99           RYVDGAPGSRVPSVAGLDVDQARQRLKDAGFQVADQPNAVNSSARYGEAV
MAV_0446|M.avium_104                RYVDGAPGSRVPSVAGLDIDAARQRIKEAGFQVADQNNFVNSSAKQGEVV
MLBr_02308|M.leprae_Br4923          RYVDGSPGSQVPSVTGLDLDAARQRLKGAGFQVADQPTLINSTAKLGAVV
MAB_0408c|M.abscessus_ATCC_199      RYVEGGPGSKVPSINGLREPEARDVLKKAGFRVADQASSVNSTAPFNEVV
                                    ***:*.***:***: *:    **  :: ***:***    :** :  . .*

Mflv_1365|M.gilvum_PYR-GCK          GTAPSGQTVPGSIVTIQISNGIAPAPPPPPAG--APPPGGPP--------
Mvan_5442|M.vanbaalenii_PYR-1       GTSPTGQTVPGSIITIQISNGIAPPPPPPPPG--APP-GLPP--------
MSMEG_6201|M.smegmatis_MC2_155      GTTPSGQTIPGSIITIQLSNGIPPPPPPPVN--IPLPGGP----------
TH_2122|M.thermoresistible__bu      GTNPSGQTIPXXYPTQFLRADLDALGVIPADKLLEVPDGTRILIAGAVTH
Mb3707|M.bovis_AF2122/97            GTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPP----------
Rv3682|M.tuberculosis_H37Rv         GTSPSGQTIPGSIVTIQISNGIPPAPPPPPLPEDGGPPPP----------
MMAR_5171|M.marinum_M               GTSPSGQTIPGSIITIQISNGIPPAPPPPP---EGEPPPP----------
MUL_4257|M.ulcerans_Agy99           GTSPSGQTIPGSIITIQISNGIPPAPPPPP---EGEPPPP----------
MAV_0446|M.avium_104                GTTPSGATIPGSIITIQVSNGIPPAPPPPP----EGAPPP----------
MLBr_02308|M.leprae_Br4923          GTTPSGQTIPGSIITIQTSSGIPPAPPPPP---EGGPPMPPS--------
MAB_0408c|M.abscessus_ATCC_199      GTSPSGTTIPGSVITILMSNGIPPAPPPLVIPGIPGAPPG----------
                                    ** *:* *:*    *     .: .            .             

Mflv_1365|M.gilvum_PYR-GCK          ---PPAGETVIQIPGLPPIT--VPVLGPPP--------PPPPPPG-----
Mvan_5442|M.vanbaalenii_PYR-1       ---PPVGQTVIQIPGLPPIT--VPVLGPPP--------PPPPPPG-----
MSMEG_6201|M.smegmatis_MC2_155      ---PEIGQTVVEIPGLPPIT--VPVLGPP---------PPPPPP------
TH_2122|M.thermoresistible__bu      RQRPATAQGVTFLN-LEDETGMVNVLCSPGVWARHRRLAQTAPALLVRGI
Mb3707|M.bovis_AF2122/97            -----VGSQVVEIPGLPPIT--IPLLAPPP-------PAP--PP------
Rv3682|M.tuberculosis_H37Rv         -----VGSQVVEIPGLPPIT--IPLLAPPP-------PAP--PP------
MMAR_5171|M.marinum_M               -----VGSQVVEIPGLPPIT--IPLLAPPP-------P------------
MUL_4257|M.ulcerans_Agy99           -----VGSQVVEIPGLPPIT--IPLLAPPP-------P------------
MAV_0446|M.avium_104                -----VGSQVVEIPGLPPIT--IPLLAPPP-------PAPGQPPP-----
MLBr_02308|M.leprae_Br4923          -----VGSQVIEIPGLPPIT--IPLLAPP---------------------
MAB_0408c|M.abscessus_ATCC_199      ----EMTTTIVNIPGLPPIT--VPVLAPPP--------------------
                                             :  :  *   *  : :* .*                     

Mflv_1365|M.gilvum_PYR-GCK          ------------------------------
Mvan_5442|M.vanbaalenii_PYR-1       ------------------------------
MSMEG_6201|M.smegmatis_MC2_155      ------------------------------
TH_2122|M.thermoresistible__bu      VQNATGAVTVVADRMRRLELRVGSRSRDFR
Mb3707|M.bovis_AF2122/97            ------------------------------
Rv3682|M.tuberculosis_H37Rv         ------------------------------
MMAR_5171|M.marinum_M               ------------------------------
MUL_4257|M.ulcerans_Agy99           ------------------------------
MAV_0446|M.avium_104                ------------------------------
MLBr_02308|M.leprae_Br4923          ------------------------------
MAB_0408c|M.abscessus_ATCC_199      ------------------------------