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MAFLRSVSCLAAAVFAVGTGIGLPTAAGEPNAAPAACPYKVSTPPAVDSSEVPAAGEPPLPLVVPPTPVG GNALGGCGIITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAMASINTLTLNKS VAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGNDAAYALARQLGGMPAALEKINLLAAKLGGRDT RVATPSGLDGPGMSTSAYDIGLFYRYAWQNPVFADIVATRTFDFPGHGDHPGYELENDNQLLYNYPGALG GKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQAAHLLDYGFNTPAGTQIGTLIEPDPSLMS TDRNPADRQRVDPQAAARISAADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3330 | dacB1 | - | 100% (405) | PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE CARBOXYPEPTIDASE) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-TRANSPEPTIDASE) (SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE) (D-AMINO ACID HYDROLASE) |
| M. tuberculosis H37Rv | Rv2911 | dacB2 | 2e-58 | 45.07% (284) | D-alanyl-D-alanine carboxypeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3363 | dacB1 | 0.0 | 100.00% (405) | penicillin-binding protein DacB1 |
| M. gilvum PYR-GCK | Mflv_4869 | - | 1e-153 | 67.98% (406) | Serine-type D-Ala-D-Ala carboxypeptidase |
| M. leprae Br4923 | MLBr_00691 | - | 0.0 | 76.39% (415) | putative D-alanyl-D-alanine carboxypeptidase |
| M. abscessus ATCC 19977 | MAB_3681 | - | 1e-141 | 63.59% (390) | penicillin-binding protein DacB1 |
| M. marinum M | MMAR_1192 | dacC | 0.0 | 77.83% (415) | penicillin-binding protein DacC |
| M. avium 104 | MAV_4305 | - | 0.0 | 78.21% (413) | D-alanyl-D-alanine carboxypeptidase |
| M. smegmatis MC2 155 | MSMEG_1661 | - | 1e-151 | 68.66% (402) | D-alanyl-D-alanine carboxypeptidase |
| M. thermoresistible (build 8) | TH_1977 | - | 1e-151 | 67.51% (394) | PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE |
| M. ulcerans Agy99 | MUL_1445 | dacC | 0.0 | 77.83% (415) | penicillin-binding protein DacC |
| M. vanbaalenii PYR-1 | Mvan_1562 | - | 1e-156 | 69.06% (404) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4869|M.gilvum_PYR-GCK ----------------MATLRTTLLRASALVTASMLALAPAAAAQPAPAA
Mvan_1562|M.vanbaalenii_PYR-1 ----------------MATLRTLLTRSSALVTAAMLILAPVAAAQPPAEA
MSMEG_1661|M.smegmatis_MC2_155 ----------------MTRRAVTAVGALALLTAPLMT-----AGVAGAEP
TH_1977|M.thermoresistible__bu ------MA----IFSSVTRRLVAVGAAIAVLAMPAISSLPTAAADPVAEA
Rv3330|M.tuberculosis_H37Rv ------MA----FLRSVSCLAAAVFA------VGTGIGLPTAAGEPNAAP
Mb3363|M.bovis_AF2122/97 ------MA----FLRSVSCLAAAVFA------VGTGIGLPTAAGEPNAAP
MMAR_1192|M.marinum_M ------MY----LLRAASCLAAAVFMAAGPAVVGMPAALPSASAEPNAEA
MUL_1445|M.ulcerans_Agy99 ------MY----LLRAASCLAAAVFMAAGPAVVGMPAALPSASAEPNAEA
MLBr_00691|M.leprae_Br4923 ------MS----FLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEPNAGP
MAV_4305|M.avium_104 ------MSTSGALVRSASCLAAALFLAAAPAVSG--TASPLGRAEPGAEP
MAB_3681|M.abscessus_ATCC_1997 MTTWTPAPDRRPSPRTAVTRLAAATAAGLIVAVLPLCAPPLASAEPGFTP
. . . .
Mflv_4869|M.gilvum_PYR-GCK ----DPCPYRVTTPPAVDASEVPKPGDPTPGPLPVPAKPMGGDALSGCGV
Mvan_1562|M.vanbaalenii_PYR-1 ----NTCPYRVTTPPAVDASEVPKPGDPTPGPLPVPAKPMGGDALSGCGV
MSMEG_1661|M.smegmatis_MC2_155 G---VDCPYRETTPPAVDASEVPKPGEAAPGPLPVPPKAIGGEALSGCGV
TH_1977|M.thermoresistible__bu G---DPCPYRETTPPAISASEVPKPGEDPPAPLPVPATAVGGDALSGCGV
Rv3330|M.tuberculosis_H37Rv ----AACPYKVSTPPAVDSSEVPAAGE-PPLPLVVPPTPVGGNALGGCGI
Mb3363|M.bovis_AF2122/97 ----AACPYKVSTPPAVDSSEVPAAGE-PPLPLVVPPTPVGGNALGGCGI
MMAR_1192|M.marinum_M NSGAQECPYRVTTPPAVDSSEVPQAGE-PPLPLAVPSAPVGGNALGGCGI
MUL_1445|M.ulcerans_Agy99 NSGAQECPYRVTTPPAVDSSEVPQAGE-PPLPLAVPSAPVGGNALGGCGI
MLBr_00691|M.leprae_Br4923 NAGPATCPYQVSTPPAVDSSEVPQTGN-PPMPLAVPPKPVGGAALNSCGI
MAV_4305|M.avium_104 NAAPTNCPYKVNTPPAVDSSEVPTAGD-PPMPLAVPAKPVGGDALGSCGI
MAB_3681|M.abscessus_ATCC_1997 P-DTSGCPYKVVTPPAVDTSEVPKAGGDPPAPLPVPAKPIGGEMLGRCDV
***: ****:.:**** .* .* ** **. .:** *. *.:
Mflv_4869|M.gilvum_PYR-GCK ITAPGTPPVPGDVSAEAWLVADLDSGDVIAARDPHGRHRPASIIKVLTAM
Mvan_1562|M.vanbaalenii_PYR-1 ITAPGTPPVPADVSAEAWLVADLDSGDVIAARDPHGRHRPASIIKVLTAM
MSMEG_1661|M.smegmatis_MC2_155 ITAPNTPPVPEDVSAEAWIVADMDTGDVIAARDPHGRHRPASIIKVLTAT
TH_1977|M.thermoresistible__bu IVAPGTPPLPTEISAEAWLVADLDTGDVIAAKDPHGRHRPASVIKALTAM
Rv3330|M.tuberculosis_H37Rv ITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAM
Mb3363|M.bovis_AF2122/97 ITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAM
MMAR_1192|M.marinum_M IAAPDTPPVPGDVSAEAWLVGDLDSGAIIAARDPHARHRPASIIKVLVAM
MUL_1445|M.ulcerans_Agy99 IAAPDTPPVPGDVSAEAWLVGDLDSGAIIAARDPHGRHRPASIIKVLVVM
MLBr_00691|M.leprae_Br4923 VTAPDTPPVPGDLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVLLAM
MAV_4305|M.avium_104 VAAPNTPPLPGDVSAEAWLVADLDSGAVIAAKDPHGRHRPASIIKVLVAM
MAB_3681|M.abscessus_ATCC_1997 ITPDGAGPVPNDISAESWLIADLNTGNVVAAKDPHARHRPASVIKVLVAM
:.. .: * * ::***:*::.*:::* ::**:***.******:**.* .
Mflv_4869|M.gilvum_PYR-GCK QALRDLPLMKTVPGTPEDAAQEGTKVGVGEGGVYTVNDLLHGLLMYSGND
Mvan_1562|M.vanbaalenii_PYR-1 QAINDLPLHKVIPGTEEDAAQEGTKVGVGPGGFYSINDLLHGLLMYSGND
MSMEG_1661|M.smegmatis_MC2_155 AALNELNLNKRVAGTQDDANAEGTRVGVGPGGQYTINDLLHGLLMYSGND
TH_1977|M.thermoresistible__bu AAINELPLNRQVHGTAQDSAIEGTKVGVGPGGVYTVRDLLHGLMMYSGND
Rv3330|M.tuberculosis_H37Rv ASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGND
Mb3363|M.bovis_AF2122/97 ASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGND
MMAR_1192|M.marinum_M VSIKELNQNKAVPGTNDDSAAEGTKVGVNAGGMYTVNQLLHGLLMHSGND
MUL_1445|M.ulcerans_Agy99 VSIKELNQNKAVPGTNDDSAAEGTKVGVNAGGMYTVNQLLHGLLMHSGND
MLBr_00691|M.leprae_Br4923 ASINTLNLNKSVAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQSGND
MAV_4305|M.avium_104 AAINTLNLNKAVPGTADDAAAEGTKVGVEEGGVFTVNQLLHGLLMHSGND
MAB_3681|M.abscessus_ATCC_1997 EAINNLNLNQAVVGTQEDANSEGTRVGVDVGGTYTVRQLLTGLLMNSGND
::. * : : ** :*: ***:*** ** :::.:** **:* ****
Mflv_4869|M.gilvum_PYR-GCK AAHALAMQMGGMDTALNKINVLAQKLGARDTRVATPSGLDGPGMSTSVYD
Mvan_1562|M.vanbaalenii_PYR-1 AAHALAMQMGGMQTALNKINALAGKLGARDTRVATPSGLDGPGMSTSAYD
MSMEG_1661|M.smegmatis_MC2_155 AAHALAMQLGGWDPALQKLNTLAAKLGGRDTRAATPSGLDGPGMSTSAYD
TH_1977|M.thermoresistible__bu AANALANQMGGVDVALDKLNALAAKLGAQDTRAASPSGLDGPGMSTSAYD
Rv3330|M.tuberculosis_H37Rv AAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYD
Mb3363|M.bovis_AF2122/97 AAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MMAR_1192|M.marinum_M AAHALAIQLGGMQTALEKINMLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MUL_1445|M.ulcerans_Agy99 AAHALAIQLGGMQTALEKINMLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MLBr_00691|M.leprae_Br4923 AAHSLAMQLGGMQQALQKINVLAAKLGGQDTRVATPSGLDGPGMSTSAYD
MAV_4305|M.avium_104 AAHALAMQLGGMQQALEKINVLAAKLGGQDTRVATPSGLDAPGMSTSAYD
MAB_3681|M.abscessus_ATCC_1997 AAHALAVQLGGMDETVAKINDMAQKLGARDTRAATPSGLDGPGMSTSAYD
** :** *:** :: *:* :* ***.:***.*:*****.******.**
Mflv_4869|M.gilvum_PYR-GCK MGLFYRYAWHNPVFADIVATRATQFPGR-------EGAG-YPIENDNKLL
Mvan_1562|M.vanbaalenii_PYR-1 IGLFYRYAWQNPVFTDIVATRSSNFPGR-------DGAG-YPIENDNKLL
MSMEG_1661|M.smegmatis_MC2_155 IALFYRYAWQNPVFADIVHTQSYQFPGR-------DGGS-YPIENDNKLL
TH_1977|M.thermoresistible__bu IALIYRYAWQDPTFSQIVATRSYHFPGR-------EGSPPYEILNDNQLL
Rv3330|M.tuberculosis_H37Rv IGLFYRYAWQNPVFADIVATRTFDFPGH-------GDHPGYELENDNQLL
Mb3363|M.bovis_AF2122/97 IGLFYRYAWQNPVFADIVATRTFDFPGH-------GDHPGYELENDNQLL
MMAR_1192|M.marinum_M IGLFYRYAWQNPIFADIVATRTFDFPGH-------GEHPGYELENDNHLL
MUL_1445|M.ulcerans_Agy99 IGLFYRYAWQNPIFADIVATRTFDFPGH-------GEHPGYELENDNHLL
MLBr_00691|M.leprae_Br4923 IGLFYRYAWQNPSFSNIVATRTFNFPGP-------GDHPGYQLENDNQLL
MAV_4305|M.avium_104 IGLFYRYAWQNPTFADIVATRTFDFPGH-------GDHPGYELENDNQLL
MAB_3681|M.abscessus_ATCC_1997 LGLFYKYAFADPTFADLVSAPKATFPGHPAKPGERDDHPAYEMTNDNKLL
:.*:*:**: :* *:::* : *** * : ***:**
Mflv_4869|M.gilvum_PYR-GCK ANYPGALGGKTGYTDDAGQTFVGAAERDGRRLVAVLMRGTRQPIAPWEQA
Mvan_1562|M.vanbaalenii_PYR-1 ANYPGALGGKTGFTDDAGQTFVGAATRDGRRLVAVLLRGTRQPIAPWEQA
MSMEG_1661|M.smegmatis_MC2_155 ANYPGALGGKTGYTDDAGQTFVGAAERDGRRLIAVLLKGTRVPIAPWEQA
TH_1977|M.thermoresistible__bu MNYPGALGGKTGFTDDAGQTFVGAAERDGRRLVAVLLRGTRQPIPPWQQA
Rv3330|M.tuberculosis_H37Rv YNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQA
Mb3363|M.bovis_AF2122/97 YNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQA
MMAR_1192|M.marinum_M YNYPGALGGKTGYTDDAGQTFVGAANHNGRRLFAVLLHGTRQPIAPWEQA
MUL_1445|M.ulcerans_Agy99 YNYPGALGGKTGYTDDAGQTFVGAANHNGRRLFAVLLHGTRQPIAPWEQA
MLBr_00691|M.leprae_Br4923 YQYPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRQPIAPWEQA
MAV_4305|M.avium_104 YKYPGALGGKTGYTDDAGQTFVGAANHDGRRLVAVLLHGTRQPIAPWEQA
MAB_3681|M.abscessus_ATCC_1997 YNYPGALGGKTGYTDDAQQTFVGAAERDGRRLVVTMLRGTRLPIAPWEQA
:**********:**** ******* ::****...:::*** **.**:**
Mflv_4869|M.gilvum_PYR-GCK ARLLDYGFATAPGTKVGTLIEPDPSLGVDRADPAVAALTKTNANANAVLP
Mvan_1562|M.vanbaalenii_PYR-1 ARLLDYGFATAPGTKVGSLIEPDPSLGVTRADPAAATTTT----ANAVLP
MSMEG_1661|M.smegmatis_MC2_155 ARLLDYGFATPPGTKVGTLVDPDPSLAPKQAEEP--SPAQ----AASVLP
TH_1977|M.thermoresistible__bu AQLLDYGFATAPGTRVGTLVDPDPSVSRQKINTSGEADTA----AAPILL
Rv3330|M.tuberculosis_H37Rv AHLLDYGFNTPAGTQIGTLIEPDPSLMSTDR-NPADRQRVD-PQAAARIS
Mb3363|M.bovis_AF2122/97 AHLLDYGFNTPAGTQIGTLIEPDPSLMSTDR-NPADRQRVD-PQAAARIS
MMAR_1192|M.marinum_M AHLLDYGFSTAQGTQIGSLIEPDPSLVAPKE-TPEARRLAD-AQAAGLVS
MUL_1445|M.ulcerans_Agy99 AHLLDYGFSTAQGTQIGSLIEPDPSLVAPKE-TPEARRLAD-AQAAGLVS
MLBr_00691|M.leprae_Br4923 AHLLDYGFSTAVGTQIGTLIEPDPTVA-----GNADRHGHG-LQAAGIMS
MAV_4305|M.avium_104 AHLLDYGFATPQGTQVGSLIAPDPSLAPAKRDGAADRLAGN-TAAAGMIS
MAB_3681|M.abscessus_ATCC_1997 AHLLDYGFSTPRDASIGKLVDPDPSLLTKPHADDTPSAQA----AGLPAE
*:****** *. .: :*.*: ***:: *
Mflv_4869|M.gilvum_PYR-GCK DVDAMPVRIGVGVIGAVIVLTLIMGARALNSRPAR-
Mvan_1562|M.vanbaalenii_PYR-1 DVDAMPVRIGVGVIGAVIVFSLIMGARALNRRPAR-
MSMEG_1661|M.smegmatis_MC2_155 PADAMPVRVGVAVVGAIIVFMLILGARQLNQRPQH-
TH_1977|M.thermoresistible__bu PADAVPVRVGVAVIGTIIVFGLIMAARSMNRRSHR-
Rv3330|M.tuberculosis_H37Rv AADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH-
Mb3363|M.bovis_AF2122/97 AADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH-
MMAR_1192|M.marinum_M SADALPVRVGVAVIGAIIVFGLMLVARSLNNRPQH-
MUL_1445|M.ulcerans_Agy99 SADALPVRVGVAVIGAIIVFGLMLVARSLNNRPQH-
MLBr_00691|M.leprae_Br4923 SNDTLPVRIGVAVVGTLIVFGLIMITRSLNRRPQH-
MAV_4305|M.avium_104 SADALPVRVGVAVIGTIVVFTLIMMARSMNRRPQHR
MAB_3681|M.abscessus_ATCC_1997 AINSVPVRVGVTIIGAMIVFGLILAARSLNRRQA--
:::***:** ::*:::*: *:: :* :* *