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TRRAVTAVGALALLTAPLMTAGVAGAEPGVDCPYRETTPPAVDASEVPKPGEAAPGPLPVPPKAIGGEAL SGCGVITAPNTPPVPEDVSAEAWIVADMDTGDVIAARDPHGRHRPASIIKVLTATAALNELNLNKRVAGT QDDANAEGTRVGVGPGGQYTINDLLHGLLMYSGNDAAHALAMQLGGWDPALQKLNTLAAKLGGRDTRAAT PSGLDGPGMSTSAYDIALFYRYAWQNPVFADIVHTQSYQFPGRDGGSYPIENDNKLLANYPGALGGKTGY TDDAGQTFVGAAERDGRRLIAVLLKGTRVPIAPWEQAARLLDYGFATPPGTKVGTLVDPDPSLAPKQAEE PSPAQAASVLPPADAMPVRVGVAVVGAIIVFMLILGARQLNQRPQH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1661 | - | - | 100% (397) | D-alanyl-D-alanine carboxypeptidase |
| M. smegmatis MC2 155 | MSMEG_2433 | - | 1e-59 | 44.41% (286) | D-alanyl-D-alanine carboxypeptidase |
| M. smegmatis MC2 155 | MSMEG_2432 | - | 3e-52 | 45.82% (251) | D-alanyl-D-alanine carboxypeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3363 | dacB1 | 1e-151 | 68.66% (402) | penicillin-binding protein DacB1 |
| M. gilvum PYR-GCK | Mflv_4869 | - | 1e-169 | 72.84% (405) | Serine-type D-Ala-D-Ala carboxypeptidase |
| M. tuberculosis H37Rv | Rv3330 | dacB1 | 1e-151 | 68.66% (402) | penicillin-binding protein DacB1 |
| M. leprae Br4923 | MLBr_00691 | - | 1e-149 | 66.58% (395) | putative D-alanyl-D-alanine carboxypeptidase |
| M. abscessus ATCC 19977 | MAB_3681 | - | 1e-140 | 60.73% (410) | penicillin-binding protein DacB1 |
| M. marinum M | MMAR_1192 | dacC | 1e-152 | 66.26% (412) | penicillin-binding protein DacC |
| M. avium 104 | MAV_4305 | - | 1e-153 | 66.59% (413) | D-alanyl-D-alanine carboxypeptidase |
| M. thermoresistible (build 8) | TH_1977 | - | 1e-161 | 69.65% (402) | PROBABLE PENICILLIN-BINDING PROTEIN DACB1 (D-ALANYL-D-ALANINE |
| M. ulcerans Agy99 | MUL_1445 | dacC | 1e-152 | 66.26% (412) | penicillin-binding protein DacC |
| M. vanbaalenii PYR-1 | Mvan_1562 | - | 1e-170 | 73.43% (399) | Serine-type D-Ala-D-Ala carboxypeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1661|M.smegmatis_MC2_155 ------------MTRRAVTAVGALALLTAPLMT-----AGVAGAEP----
TH_1977|M.thermoresistible__bu ------MAIFSSVTRRLVAVGAAIAVLAMPAISSLPTAAADPVAEA----
Mflv_4869|M.gilvum_PYR-GCK ----------MATLRTTLLRASALVTASMLALAP---AAAAQPAPA----
Mvan_1562|M.vanbaalenii_PYR-1 ----------MATLRTLLTRSSALVTAAMLILAP---VAAAQPPAE----
MLBr_00691|M.leprae_Br4923 ------MS----FLRSTACLAAAVFAIVGPVALDLPTAVPVGHAEPNAGP
MAV_4305|M.avium_104 ------MSTSGALVRSASCLAAALFLAAAPAVSG--TASPLGRAEPGAEP
Mb3363|M.bovis_AF2122/97 ------MA----FLRSVSCLAAAVFA------VGTGIGLPTAAGEPNAAP
Rv3330|M.tuberculosis_H37Rv ------MA----FLRSVSCLAAAVFA------VGTGIGLPTAAGEPNAAP
MMAR_1192|M.marinum_M ------MY----LLRAASCLAAAVFMAAGPAVVGMPAALPSASAEPNAEA
MUL_1445|M.ulcerans_Agy99 ------MY----LLRAASCLAAAVFMAAGPAVVGMPAALPSASAEPNAEA
MAB_3681|M.abscessus_ATCC_1997 MTTWTPAPDRRPSPRTAVTRLAAATAAGLIVAVLPLCAPPLASAEPGFTP
* .*
MSMEG_1661|M.smegmatis_MC2_155 ---GVDCPYRETTPPAVDASEVPKPGEAAPGPLPVPPKAIGGEALSGCGV
TH_1977|M.thermoresistible__bu ---GDPCPYRETTPPAISASEVPKPGEDPPAPLPVPATAVGGDALSGCGV
Mflv_4869|M.gilvum_PYR-GCK ---ADPCPYRVTTPPAVDASEVPKPGDPTPGPLPVPAKPMGGDALSGCGV
Mvan_1562|M.vanbaalenii_PYR-1 ---ANTCPYRVTTPPAVDASEVPKPGDPTPGPLPVPAKPMGGDALSGCGV
MLBr_00691|M.leprae_Br4923 NAGPATCPYQVSTPPAVDSSEVPQTGN-PPMPLAVPPKPVGGAALNSCGI
MAV_4305|M.avium_104 NAAPTNCPYKVNTPPAVDSSEVPTAGD-PPMPLAVPAKPVGGDALGSCGI
Mb3363|M.bovis_AF2122/97 ----AACPYKVSTPPAVDSSEVPAAGE-PPLPLVVPPTPVGGNALGGCGI
Rv3330|M.tuberculosis_H37Rv ----AACPYKVSTPPAVDSSEVPAAGE-PPLPLVVPPTPVGGNALGGCGI
MMAR_1192|M.marinum_M NSGAQECPYRVTTPPAVDSSEVPQAGE-PPLPLAVPSAPVGGNALGGCGI
MUL_1445|M.ulcerans_Agy99 NSGAQECPYRVTTPPAVDSSEVPQAGE-PPLPLAVPSAPVGGNALGGCGI
MAB_3681|M.abscessus_ATCC_1997 -PDTSGCPYKVVTPPAVDTSEVPKAGGDPPAPLPVPAKPIGGEMLGRCDV
***: ****:.:**** .* .* ** **. .:** *. *.:
MSMEG_1661|M.smegmatis_MC2_155 ITAPNTPPVPEDVSAEAWIVADMDTGDVIAARDPHGRHRPASIIKVLTAT
TH_1977|M.thermoresistible__bu IVAPGTPPLPTEISAEAWLVADLDTGDVIAAKDPHGRHRPASVIKALTAM
Mflv_4869|M.gilvum_PYR-GCK ITAPGTPPVPGDVSAEAWLVADLDSGDVIAARDPHGRHRPASIIKVLTAM
Mvan_1562|M.vanbaalenii_PYR-1 ITAPGTPPVPADVSAEAWLVADLDSGDVIAARDPHGRHRPASIIKVLTAM
MLBr_00691|M.leprae_Br4923 VTAPDTPPVPGDLSAEAWLVADLNSGAVIAARDPHGRHRPASIIKVLLAM
MAV_4305|M.avium_104 VAAPNTPPLPGDVSAEAWLVADLDSGAVIAAKDPHGRHRPASIIKVLVAM
Mb3363|M.bovis_AF2122/97 ITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAM
Rv3330|M.tuberculosis_H37Rv ITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAM
MMAR_1192|M.marinum_M IAAPDTPPVPGDVSAEAWLVGDLDSGAIIAARDPHARHRPASIIKVLVAM
MUL_1445|M.ulcerans_Agy99 IAAPDTPPVPGDVSAEAWLVGDLDSGAIIAARDPHGRHRPASIIKVLVVM
MAB_3681|M.abscessus_ATCC_1997 ITPDGAGPVPNDISAESWLIADLNTGNVVAAKDPHARHRPASVIKVLVAM
:.. .: * * ::***:*::.*:::* ::**:***.******:**.* .
MSMEG_1661|M.smegmatis_MC2_155 AALNELNLNKRVAGTQDDANAEGTRVGVGPGGQYTINDLLHGLLMYSGND
TH_1977|M.thermoresistible__bu AAINELPLNRQVHGTAQDSAIEGTKVGVGPGGVYTVRDLLHGLMMYSGND
Mflv_4869|M.gilvum_PYR-GCK QALRDLPLMKTVPGTPEDAAQEGTKVGVGEGGVYTVNDLLHGLLMYSGND
Mvan_1562|M.vanbaalenii_PYR-1 QAINDLPLHKVIPGTEEDAAQEGTKVGVGPGGFYSINDLLHGLLMYSGND
MLBr_00691|M.leprae_Br4923 ASINTLNLNKSVAGTAEDAAAEGTKVGVHDGGTYTINQLLHGLLMQSGND
MAV_4305|M.avium_104 AAINTLNLNKAVPGTADDAAAEGTKVGVEEGGVFTVNQLLHGLLMHSGND
Mb3363|M.bovis_AF2122/97 ASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGND
Rv3330|M.tuberculosis_H37Rv ASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGND
MMAR_1192|M.marinum_M VSIKELNQNKAVPGTNDDSAAEGTKVGVNAGGMYTVNQLLHGLLMHSGND
MUL_1445|M.ulcerans_Agy99 VSIKELNQNKAVPGTNDDSAAEGTKVGVNAGGMYTVNQLLHGLLMHSGND
MAB_3681|M.abscessus_ATCC_1997 EAINNLNLNQAVVGTQEDANSEGTRVGVDVGGTYTVRQLLTGLLMNSGND
::. * : : ** :*: ***:*** ** :::.:** **:* ****
MSMEG_1661|M.smegmatis_MC2_155 AAHALAMQLGGWDPALQKLNTLAAKLGGRDTRAATPSGLDGPGMSTSAYD
TH_1977|M.thermoresistible__bu AANALANQMGGVDVALDKLNALAAKLGAQDTRAASPSGLDGPGMSTSAYD
Mflv_4869|M.gilvum_PYR-GCK AAHALAMQMGGMDTALNKINVLAQKLGARDTRVATPSGLDGPGMSTSVYD
Mvan_1562|M.vanbaalenii_PYR-1 AAHALAMQMGGMQTALNKINALAGKLGARDTRVATPSGLDGPGMSTSAYD
MLBr_00691|M.leprae_Br4923 AAHSLAMQLGGMQQALQKINVLAAKLGGQDTRVATPSGLDGPGMSTSAYD
MAV_4305|M.avium_104 AAHALAMQLGGMQQALEKINVLAAKLGGQDTRVATPSGLDAPGMSTSAYD
Mb3363|M.bovis_AF2122/97 AAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYD
Rv3330|M.tuberculosis_H37Rv AAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MMAR_1192|M.marinum_M AAHALAIQLGGMQTALEKINMLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MUL_1445|M.ulcerans_Agy99 AAHALAIQLGGMQTALEKINMLAAKLGGRDTRVATPSGLDGPGMSTSAYD
MAB_3681|M.abscessus_ATCC_1997 AAHALAVQLGGMDETVAKINDMAQKLGARDTRAATPSGLDGPGMSTSAYD
** :** *:** :: *:* :* ***.:***.*:*****.******.**
MSMEG_1661|M.smegmatis_MC2_155 IALFYRYAWQNPVFADIVHTQSYQFPGR-------DGGS-YPIENDNKLL
TH_1977|M.thermoresistible__bu IALIYRYAWQDPTFSQIVATRSYHFPGR-------EGSPPYEILNDNQLL
Mflv_4869|M.gilvum_PYR-GCK MGLFYRYAWHNPVFADIVATRATQFPGR-------EGAG-YPIENDNKLL
Mvan_1562|M.vanbaalenii_PYR-1 IGLFYRYAWQNPVFTDIVATRSSNFPGR-------DGAG-YPIENDNKLL
MLBr_00691|M.leprae_Br4923 IGLFYRYAWQNPSFSNIVATRTFNFPGP-------GDHPGYQLENDNQLL
MAV_4305|M.avium_104 IGLFYRYAWQNPTFADIVATRTFDFPGH-------GDHPGYELENDNQLL
Mb3363|M.bovis_AF2122/97 IGLFYRYAWQNPVFADIVATRTFDFPGH-------GDHPGYELENDNQLL
Rv3330|M.tuberculosis_H37Rv IGLFYRYAWQNPVFADIVATRTFDFPGH-------GDHPGYELENDNQLL
MMAR_1192|M.marinum_M IGLFYRYAWQNPIFADIVATRTFDFPGH-------GEHPGYELENDNHLL
MUL_1445|M.ulcerans_Agy99 IGLFYRYAWQNPIFADIVATRTFDFPGH-------GEHPGYELENDNHLL
MAB_3681|M.abscessus_ATCC_1997 LGLFYKYAFADPTFADLVSAPKATFPGHPAKPGERDDHPAYEMTNDNKLL
:.*:*:**: :* *:::* : *** * : ***:**
MSMEG_1661|M.smegmatis_MC2_155 ANYPGALGGKTGYTDDAGQTFVGAAERDGRRLIAVLLKGTRVPIAPWEQA
TH_1977|M.thermoresistible__bu MNYPGALGGKTGFTDDAGQTFVGAAERDGRRLVAVLLRGTRQPIPPWQQA
Mflv_4869|M.gilvum_PYR-GCK ANYPGALGGKTGYTDDAGQTFVGAAERDGRRLVAVLMRGTRQPIAPWEQA
Mvan_1562|M.vanbaalenii_PYR-1 ANYPGALGGKTGFTDDAGQTFVGAATRDGRRLVAVLLRGTRQPIAPWEQA
MLBr_00691|M.leprae_Br4923 YQYPGALGGKTGYTDDAGQTFVGAANRNGRRLMAVLLHGTRQPIAPWEQA
MAV_4305|M.avium_104 YKYPGALGGKTGYTDDAGQTFVGAANHDGRRLVAVLLHGTRQPIAPWEQA
Mb3363|M.bovis_AF2122/97 YNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQA
Rv3330|M.tuberculosis_H37Rv YNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQA
MMAR_1192|M.marinum_M YNYPGALGGKTGYTDDAGQTFVGAANHNGRRLFAVLLHGTRQPIAPWEQA
MUL_1445|M.ulcerans_Agy99 YNYPGALGGKTGYTDDAGQTFVGAANHNGRRLFAVLLHGTRQPIAPWEQA
MAB_3681|M.abscessus_ATCC_1997 YNYPGALGGKTGYTDDAQQTFVGAAERDGRRLVVTMLRGTRLPIAPWEQA
:**********:**** ******* ::****...:::*** **.**:**
MSMEG_1661|M.smegmatis_MC2_155 ARLLDYGFATPPGTKVGTLVDPDPSLAPKQAEEP--SPAQA----ASVLP
TH_1977|M.thermoresistible__bu AQLLDYGFATAPGTRVGTLVDPDPSVSRQKINTSGEADTAA----APILL
Mflv_4869|M.gilvum_PYR-GCK ARLLDYGFATAPGTKVGTLIEPDPSLGVDRADPAVAALTKTNANANAVLP
Mvan_1562|M.vanbaalenii_PYR-1 ARLLDYGFATAPGTKVGSLIEPDPSLGVTRADPAAATTTT----ANAVLP
MLBr_00691|M.leprae_Br4923 AHLLDYGFSTAVGTQIGTLIEPDPTVA-----GNADRHGHG-LQAAGIMS
MAV_4305|M.avium_104 AHLLDYGFATPQGTQVGSLIAPDPSLAPAKRDGAADRLAGN-TAAAGMIS
Mb3363|M.bovis_AF2122/97 AHLLDYGFNTPAGTQIGTLIEPDPSLMSTDR-NPADRQRVD-PQAAARIS
Rv3330|M.tuberculosis_H37Rv AHLLDYGFNTPAGTQIGTLIEPDPSLMSTDR-NPADRQRVD-PQAAARIS
MMAR_1192|M.marinum_M AHLLDYGFSTAQGTQIGSLIEPDPSLVAPKE-TPEARRLAD-AQAAGLVS
MUL_1445|M.ulcerans_Agy99 AHLLDYGFSTAQGTQIGSLIEPDPSLVAPKE-TPEARRLAD-AQAAGLVS
MAB_3681|M.abscessus_ATCC_1997 AHLLDYGFSTPRDASIGKLVDPDPSLLTKPHADDTPSAQAA----GLPAE
*:****** *. .: :*.*: ***::
MSMEG_1661|M.smegmatis_MC2_155 PADAMPVRVGVAVVGAIIVFMLILGARQLNQRPQH-
TH_1977|M.thermoresistible__bu PADAVPVRVGVAVIGTIIVFGLIMAARSMNRRSHR-
Mflv_4869|M.gilvum_PYR-GCK DVDAMPVRIGVGVIGAVIVLTLIMGARALNSRPAR-
Mvan_1562|M.vanbaalenii_PYR-1 DVDAMPVRIGVGVIGAVIVFSLIMGARALNRRPAR-
MLBr_00691|M.leprae_Br4923 SNDTLPVRIGVAVVGTLIVFGLIMITRSLNRRPQH-
MAV_4305|M.avium_104 SADALPVRVGVAVIGTIVVFTLIMMARSMNRRPQHR
Mb3363|M.bovis_AF2122/97 AADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH-
Rv3330|M.tuberculosis_H37Rv AADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH-
MMAR_1192|M.marinum_M SADALPVRVGVAVIGAIIVFGLMLVARSLNNRPQH-
MUL_1445|M.ulcerans_Agy99 SADALPVRVGVAVIGAIIVFGLMLVARSLNNRPQH-
MAB_3681|M.abscessus_ATCC_1997 AINSVPVRVGVTIIGAMIVFGLILAARSLNRRQA--
:::***:** ::*:::*: *:: :* :* *