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MNQPDIKGSCASEFTKVRDAFERNFVLRNEVGAAVAVWVDGDLVVNLWGGSADAGGTRPWQHDTLATVLS GTKALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAIGPRGRLGWEQVADWDFV CEQLAAAEPWWQPGAAQGYHMTTFGFILGEVFRRVTGRTVGQYLRTEIAEPLGADVHIGLHPGEQLRCAD LVDKPHIRQLLADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNGQVSALGLAT FYNGLAQEKLLSREHMELVRVSQGGFDTDLVLGPRVADHGWGLGYMLNQRGVNGPNPRIFGHGGLGGSFG FVDLEHRIGYAYVMNRFDATKANADPRSVVLSNEVYAALGVNRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2463 | lipP | - | 100% (394) | PROBABLE ESTERASE/LIPASE LIPP |
| M. tuberculosis H37Rv | Rv1923 | lipD | 6e-44 | 35.04% (371) | lipase LIPD |
| M. tuberculosis H37Rv | Rv1497 | lipL | 4e-40 | 33.42% (380) | esterase LipL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2490 | lipP | 0.0 | 100.00% (394) | esterase/lipase LipP |
| M. gilvum PYR-GCK | Mflv_3647 | - | 2e-40 | 35.17% (381) | beta-lactamase |
| M. leprae Br4923 | MLBr_00119 | lipE | 4e-17 | 33.82% (136) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0853 | - | 1e-152 | 65.37% (387) | esterase/lipase LipP |
| M. marinum M | MMAR_3810 | lipP | 0.0 | 84.14% (391) | esterase/lipase LipP |
| M. avium 104 | MAV_1709 | lipP | 0.0 | 82.90% (386) | carboxylesterase, putative |
| M. smegmatis MC2 155 | MSMEG_4680 | lipP | 1e-168 | 72.54% (386) | carboxylesterase, putative |
| M. thermoresistible (build 8) | TH_0350 | lipP | 1e-164 | 71.39% (388) | PROBABLE ESTERASE/LIPASE LIPP |
| M. ulcerans Agy99 | MUL_3735 | lipP | 0.0 | 85.91% (362) | esterase/lipase LipP |
| M. vanbaalenii PYR-1 | Mvan_5383 | - | 1e-57 | 35.62% (393) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2463|M.tuberculosis_H37Rv -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
Mb2490|M.bovis_AF2122/97 -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
MMAR_3810|M.marinum_M -------------------MSDVDIYGSCARKFQRVRAAFERNFAQGMEV
MUL_3735|M.ulcerans_Agy99 -----------------------------------------------MEV
MAV_1709|M.avium_104 ---------------MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEV
MSMEG_4680|M.smegmatis_MC2_155 ---------MRPGGSLTGQQLAIPISGTCAPGFERVRTAFEQNFTERNEV
TH_0350|M.thermoresistible__bu ---------MS--ETFQPVRSIPAVHGTCAPGFEGVRTAFVDNFTERGEI
MAB_0853|M.abscessus_ATCC_1997 ----------------MSTSLDVAVNGTNSPDFDNVRRAFALNFLENDEL
Mvan_5383|M.vanbaalenii_PYR-1 -----------------MWSDMSDVAGLCDPRFESVAAALADEIACGEEL
Mflv_3647|M.gilvum_PYR-GCK MTGVNSRERDEALSHGHGGHLPRGVQGAADPNFTCAVRAFAQMFPHRRFG
MLBr_00119|M.leprae_Br4923 -MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHP
Rv2463|M.tuberculosis_H37Rv GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
Mb2490|M.bovis_AF2122/97 GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
MMAR_3810|M.marinum_M GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MUL_3735|M.ulcerans_Agy99 GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MAV_1709|M.avium_104 GAAVAVWVDGSLVVN--LWGGWADA------ARTRPWQQNTLTTVLSGTK
MSMEG_4680|M.smegmatis_MC2_155 GAAVAVWVEGDLVVS--LWGGHADA------ARTRPWREDTLASVYSGSK
TH_0350|M.thermoresistible__bu GAAVAVWVDGELVVD--LWGGSADA------EGRLSWRRDTLASVFSGSK
MAB_0853|M.abscessus_ATCC_1997 GAAVAIWVDGELVVN--LWAGWADE------ARTRPWTEDTLAPVYSGTK
Mvan_5383|M.vanbaalenii_PYR-1 GASIAVDLDGELVVD--IWAGYVDR------AKTIPWQRDTIVNFWSCTK
Mflv_3647|M.gilvum_PYR-GCK GGALAVYLNGEPVVD--VWTGWADR------RGKRRWTADTAPMVFSATK
MLBr_00119|M.leprae_Br4923 AIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAK
. :.: .* *:. : * : :* * :*
Rv2463|M.tuberculosis_H37Rv ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
Mb2490|M.bovis_AF2122/97 ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
MMAR_3810|M.marinum_M ALTATCVHQLADRGELDLHAPVARYWPEFGQAGKEAITVAMVLSHRSGVI
MUL_3735|M.ulcerans_Agy99 ALTATCVHQLADRGELNLHAPVARYWPEFRQAGKEAITVAMVLSHRSGVI
MAV_1709|M.avium_104 GLSATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVI
MSMEG_4680|M.smegmatis_MC2_155 GLTSTCIHLLADRGEIDLDAPVARYWPEFAQAGKRDITVASVLAHRSGTI
TH_0350|M.thermoresistible__bu GLTATCVHLLADRGEIDLDAPIARYWPEFGQAGKDAITTAMVLGHRSGVI
MAB_0853|M.abscessus_ATCC_1997 GLMSTCVHMLVERGVLDLYAPVARYWPEFGQGGKESITLAMVLGHRSGVI
Mvan_5383|M.vanbaalenii_PYR-1 TLTALAALILVDRGELDPFSTVARYWPEFAANGKADIEVRHLLSHTSGVS
Mflv_3647|M.gilvum_PYR-GCK GVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRELMRHRAGLS
MLBr_00119|M.leprae_Br4923 AITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVP
: : *.:** :. :..* : ** :: * :*
Rv2463|M.tuberculosis_H37Rv GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
Mb2490|M.bovis_AF2122/97 GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
MMAR_3810|M.marinum_M GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MUL_3735|M.ulcerans_Agy99 GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MAV_1709|M.avium_104 GPRTR-MRWEQVADWDYVCEQLAAAEPWWEPGTAQGYHMTTFGFIMGEVF
MSMEG_4680|M.smegmatis_MC2_155 GPREP-MDWREITDWDAVCTRIAASEPWWPPGTAQGYQVVTFGFILGELV
TH_0350|M.thermoresistible__bu GPRTP-MRPEQTLDWDAVCAALAAAGPWWPPGAAQGYHMVTFGFILGEIV
MAB_0853|M.abscessus_ATCC_1997 GPRTR-LTPEQAANWDEVCEHIARATPWWEPGTAQGYHMATFGFILGEVV
Mvan_5383|M.vanbaalenii_PYR-1 GWQTP-FGVEDIYDWAKATSHLAGQAPWWQPGTASGYHAMNYGHLVGELV
Mflv_3647|M.gilvum_PYR-GCK QLNG--AAKTDLMDHLVMEERLAAAPASWLVG-RPAYHAFTFGWLLSGLA
MLBr_00119|M.leprae_Br4923 FPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREII
: :: . : * *: .:* :: :
Rv2463|M.tuberculosis_H37Rv RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
Mb2490|M.bovis_AF2122/97 RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
MMAR_3810|M.marinum_M RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MUL_3735|M.ulcerans_Agy99 RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MAV_1709|M.avium_104 RRVTGRTIGHYLRTEIAGPFGAD-VHIGLPLAEQHRCAERVNKPHARDLL
MSMEG_4680|M.smegmatis_MC2_155 RRVTGRTLGQYLRTEIAEPLGAD-IHIGLPRSEHRRCAEMVNKPTVRGVL
TH_0350|M.thermoresistible__bu RRVTGRSPGRFLRTEIAEPLGAD-VHIGLPHTEHHRCAEMVNKPHIRDVL
MAB_0853|M.abscessus_ATCC_1997 RRTTGKTLGQFLRTEIAEPYGLD-VHVGLPHSEHHRCAELINKPYLRDVF
Mvan_5383|M.vanbaalenii_PYR-1 RRITGTPLKDFVAEQIAVPLGAD-VQIGARPEDDHRIAELVPPP-PRDRG
Mflv_3647|M.gilvum_PYR-GCK RSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARIIGPQTRLQN
MLBr_00119|M.leprae_Br4923 WTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVP----------LVALS
** : :: * . :.* :
Rv2463|M.tuberculosis_H37Rv ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
Mb2490|M.bovis_AF2122/97 ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
MMAR_3810|M.marinum_M ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MUL_3735|M.ulcerans_Agy99 ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MAV_1709|M.avium_104 ADANAPTDPRSLAEHPKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNG
MSMEG_4680|M.smegmatis_MC2_155 ADFGLP-RPTSLDDHPMAGFAVSMDFVPDDELGVHDLSAWRTAEFPSTNG
TH_0350|M.thermoresistible__bu AAGGAPAHPERLDEHPMAGLAVAMGFIPDDELGSADLTGWRAAEFPATNG
MAB_0853|M.abscessus_ATCC_1997 R--GAPGEFDCMSDHPLAGPLISGDFIPDDEIARKDIALWRALEFPGTNA
Mvan_5383|M.vanbaalenii_PYR-1 VDRLPPDHPAVKTFAAFPPGAYGAAHAETEAWRRADIG--GANGHGNARG
Mflv_3647|M.gilvum_PYR-GCK PIFNAVAPHIAALPFSAG---FGAMYFPGVKSFVQGDTPLLDGEIPAANG
MLBr_00119|M.leprae_Br4923 HATGRPLPPIIAAIFRKAIGGTVHEVIPYTNTPPFLTTIVPSSNTVSTAN
:
Rv2463|M.tuberculosis_H37Rv QVSALGLATFYN-GLAQEKLLS--REHMELVRVSQGGFDTDLVLGPRVAD
Mb2490|M.bovis_AF2122/97 QVSALGLATFYN-GLAQEKLLS--REHMELVRVSQGGFDTDLVLGPRVAD
MMAR_3810|M.marinum_M QVSALGLATFYN-ALAQEKLLS--REHMDLVRVSQGGFDTDLVLGPRVAD
MUL_3735|M.ulcerans_Agy99 QVSALGLATFYN-ALAQEKLLS--REHMDLVRVSQGGFDTDLVLGPRVAD
MAV_1709|M.avium_104 QVSALGLATFYN-ALAQEKLLS--REHMDRVRVCQGGLDTDLVLGPRVAD
MSMEG_4680|M.smegmatis_MC2_155 HVSALGMATFYN-ALAQEKLLS--RELMERCRVSQGGFDTDLVLGPRVAD
TH_0350|M.thermoresistible__bu HVSAVGLATVYH-ALAREQLIS--RGHLERCRMSQGGFDPDLVLGPRVAD
MAB_0853|M.abscessus_ATCC_1997 HVSALGMATFYN-AMALGKLLS--HEHMDVVRVSQGGFDPDVVLGPRVAN
Mvan_5383|M.vanbaalenii_PYR-1 LVRALSPISLGG-TANGVQVVD--PRTVELIFAEQSSGMDQVLFVP--LR
Mflv_3647|M.gilvum_PYR-GCK VATARALARMYG-AIANEGRIDGLQYLSRETTAVLAGRRSLRLDHSMVMP
MLBr_00119|M.leprae_Br4923 ELSRFAEIWLRGGELDGIRVLR--SETLLGAVAECRRLRPDFVVGLMPAR
. . : :
Rv2463|M.tuberculosis_H37Rv HGWGLGYMLNQRGVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
Mb2490|M.bovis_AF2122/97 HGWGLGYMLNQRGVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MMAR_3810|M.marinum_M HGWGLGYMLNQRAVNGPNQ-KIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MUL_3735|M.ulcerans_Agy99 HGWGLGYMLNQRAVNGPNQ-KIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MAV_1709|M.avium_104 HGWGLGYMLNQRCVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MSMEG_4680|M.smegmatis_MC2_155 HGWGLGYMLNQRGVAGPNR-RTFGHGGSGGSFAFVDLEHRIGYAYVMNHF
TH_0350|M.thermoresistible__bu HGWGLGYMLNQRGHAGPNR-RVFGHGGSGGSFGFADLEHRIGYAYVMNNF
MAB_0853|M.abscessus_ATCC_1997 HGWGLGYMLNQRCYAGPNQ-KTFGHGGSGGSYAFVDLEHRIGYSYVMNQF
Mvan_5383|M.vanbaalenii_PYR-1 FGIGFGLPTPQSVPAVPDG-KVCWWGGWGGSLVVMDLDRRATFAYVMNKM
Mflv_3647|M.gilvum_PYR-GCK LSFHLGYHGLPIPGLLPG----FGHVGLGGSLGWADPETGLAFGFVHNRL
MLBr_00119|M.leprae_Br4923 WGTGFILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRSMAAGLISSGK
. : . * . * : . : .
Rv2463|M.tuberculosis_H37Rv DATKANADPRSVVLSNEVYAALGVNRS----------------------
Mb2490|M.bovis_AF2122/97 DATKANADPRSVVLSNEVYAALGVNRS----------------------
MMAR_3810|M.marinum_M DASKANADPRSVALSNEVYAALDVAAD----------------------
MUL_3735|M.ulcerans_Agy99 DASKANADPRSVALSNEVYAALDVAAD----------------------
MAV_1709|M.avium_104 DATKANADPRSLALSNEVYSVLGVR------------------------
MSMEG_4680|M.smegmatis_MC2_155 DATKCNADPRTVALSNQVYSALGVI------------------------
TH_0350|M.thermoresistible__bu DATKAHADPRSVALSDAVYSALGVTAHRSAAPVGAAGRR----------
MAB_0853|M.abscessus_ATCC_1997 DVTKADADPRSVRLINELYTTLGVSPAGESL------------------
Mvan_5383|M.vanbaalenii_PYR-1 GG-GTTGTPRTVRYAKLIDAALQDARG----------------------
Mflv_3647|M.gilvum_PYR-GCK LTPMVVSDQAGFVATAALLRRGASQARKNGYRRVREYGSPFSDVAATAV
MLBr_00119|M.leprae_Br4923 PGQDPNAG-RYGALMNTITAEIPVH------------------------
. :