For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSTSLDVAVNGTNSPDFDNVRRAFALNFLENDELGAAVAIWVDGELVVNLWAGWADEARTRPWTEDTLAP VYSGTKGLMSTCVHMLVERGVLDLYAPVARYWPEFGQGGKESITLAMVLGHRSGVIGPRTRLTPEQAANW DEVCEHIARATPWWEPGTAQGYHMATFGFILGEVVRRTTGKTLGQFLRTEIAEPYGLDVHVGLPHSEHHR CAELINKPYLRDVFRGAPGEFDCMSDHPLAGPLISGDFIPDDEIARKDIALWRALEFPGTNAHVSALGMA TFYNAMALGKLLSHEHMDVVRVSQGGFDPDVVLGPRVANHGWGLGYMLNQRCYAGPNQKTFGHGGSGGSY AFVDLEHRIGYSYVMNQFDVTKADADPRSVRLINELYTTLGVSPAGESL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0853 | - | - | 100% (399) | esterase/lipase LipP |
| M. abscessus ATCC 19977 | MAB_4006 | - | 5e-39 | 32.20% (382) | putative lipase/esterase/beta-lactamase |
| M. abscessus ATCC 19977 | MAB_1387 | - | 2e-38 | 31.73% (394) | putative esterase/lipase/beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2490 | lipP | 1e-152 | 65.37% (387) | esterase/lipase LipP |
| M. gilvum PYR-GCK | Mflv_3647 | - | 6e-36 | 31.30% (377) | beta-lactamase |
| M. tuberculosis H37Rv | Rv2463 | lipP | 1e-152 | 65.37% (387) | esterase/lipase LipP |
| M. leprae Br4923 | MLBr_00119 | lipE | 2e-17 | 33.54% (164) | putative hydrolase |
| M. marinum M | MMAR_3810 | lipP | 1e-153 | 65.90% (390) | esterase/lipase LipP |
| M. avium 104 | MAV_1709 | lipP | 1e-159 | 67.35% (389) | carboxylesterase, putative |
| M. smegmatis MC2 155 | MSMEG_4680 | lipP | 1e-155 | 65.38% (390) | carboxylesterase, putative |
| M. thermoresistible (build 8) | TH_0350 | lipP | 1e-155 | 64.69% (388) | PROBABLE ESTERASE/LIPASE LIPP |
| M. ulcerans Agy99 | MUL_3735 | lipP | 1e-146 | 67.49% (363) | esterase/lipase LipP |
| M. vanbaalenii PYR-1 | Mvan_5383 | - | 2e-59 | 36.22% (381) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4680|M.smegmatis_MC2_155 ---------MRPGGSLTGQQLAIPISGTCAPGFERVRTAFEQNFTERNEV
TH_0350|M.thermoresistible__bu ---------MS--ETFQPVRSIPAVHGTCAPGFEGVRTAFVDNFTERGEI
Mb2490|M.bovis_AF2122/97 -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
Rv2463|M.tuberculosis_H37Rv -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
MMAR_3810|M.marinum_M -------------------MSDVDIYGSCARKFQRVRAAFERNFAQGMEV
MUL_3735|M.ulcerans_Agy99 -----------------------------------------------MEV
MAV_1709|M.avium_104 ---------------MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEV
MAB_0853|M.abscessus_ATCC_1997 ----------------MSTSLDVAVNGTNSPDFDNVRRAFALNFLENDEL
Mvan_5383|M.vanbaalenii_PYR-1 -----------------MWSDMSDVAGLCDPRFESVAAALADEIACGEEL
Mflv_3647|M.gilvum_PYR-GCK MTGVNSRERDEALSHGHGGHLPRGVQGAADPNFTCAVRAFAQMFPHRRFG
MLBr_00119|M.leprae_Br4923 -MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHP
MSMEG_4680|M.smegmatis_MC2_155 GAAVAVWVEGDLVVS--LWGGHADA------ARTRPWREDTLASVYSGSK
TH_0350|M.thermoresistible__bu GAAVAVWVDGELVVD--LWGGSADA------EGRLSWRRDTLASVFSGSK
Mb2490|M.bovis_AF2122/97 GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
Rv2463|M.tuberculosis_H37Rv GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
MMAR_3810|M.marinum_M GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MUL_3735|M.ulcerans_Agy99 GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MAV_1709|M.avium_104 GAAVAVWVDGSLVVN--LWGGWADA------ARTRPWQQNTLTTVLSGTK
MAB_0853|M.abscessus_ATCC_1997 GAAVAIWVDGELVVN--LWAGWADE------ARTRPWTEDTLAPVYSGTK
Mvan_5383|M.vanbaalenii_PYR-1 GASIAVDLDGELVVD--IWAGYVDR------AKTIPWQRDTIVNFWSCTK
Mflv_3647|M.gilvum_PYR-GCK GGALAVYLNGEPVVD--VWTGWADR------RGKRRWTADTAPMVFSATK
MLBr_00119|M.leprae_Br4923 AIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAK
. :.: .* *:. : * : :* * :*
MSMEG_4680|M.smegmatis_MC2_155 GLTSTCIHLLADRGEIDLDAPVARYWPEFAQAGKRDITVASVLAHRSGTI
TH_0350|M.thermoresistible__bu GLTATCVHLLADRGEIDLDAPIARYWPEFGQAGKDAITTAMVLGHRSGVI
Mb2490|M.bovis_AF2122/97 ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
Rv2463|M.tuberculosis_H37Rv ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
MMAR_3810|M.marinum_M ALTATCVHQLADRGELDLHAPVARYWPEFGQAGKEAITVAMVLSHRSGVI
MUL_3735|M.ulcerans_Agy99 ALTATCVHQLADRGELNLHAPVARYWPEFRQAGKEAITVAMVLSHRSGVI
MAV_1709|M.avium_104 GLSATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVI
MAB_0853|M.abscessus_ATCC_1997 GLMSTCVHMLVERGVLDLYAPVARYWPEFGQGGKESITLAMVLGHRSGVI
Mvan_5383|M.vanbaalenii_PYR-1 TLTALAALILVDRGELDPFSTVARYWPEFAANGKADIEVRHLLSHTSGVS
Mflv_3647|M.gilvum_PYR-GCK GVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRELMRHRAGLS
MLBr_00119|M.leprae_Br4923 AITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVP
: : *.:** :. :..* : ** :: * :*
MSMEG_4680|M.smegmatis_MC2_155 GPREP-MDWREITDWDAVCTRIAASEPWWPPGTAQGYQVVTFGFILGELV
TH_0350|M.thermoresistible__bu GPRTP-MRPEQTLDWDAVCAALAAAGPWWPPGAAQGYHMVTFGFILGEIV
Mb2490|M.bovis_AF2122/97 GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
Rv2463|M.tuberculosis_H37Rv GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
MMAR_3810|M.marinum_M GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MUL_3735|M.ulcerans_Agy99 GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MAV_1709|M.avium_104 GPRTR-MRWEQVADWDYVCEQLAAAEPWWEPGTAQGYHMTTFGFIMGEVF
MAB_0853|M.abscessus_ATCC_1997 GPRTR-LTPEQAANWDEVCEHIARATPWWEPGTAQGYHMATFGFILGEVV
Mvan_5383|M.vanbaalenii_PYR-1 GWQTP-FGVEDIYDWAKATSHLAGQAPWWQPGTASGYHAMNYGHLVGELV
Mflv_3647|M.gilvum_PYR-GCK QLNG--AAKTDLMDHLVMEERLAAAPASWLVG-RPAYHAFTFGWLLSGLA
MLBr_00119|M.leprae_Br4923 FPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREII
: :: . : * *: .:* :: :
MSMEG_4680|M.smegmatis_MC2_155 RRVTGRTLGQYLRTEIAEPLGAD-IHIGLPRSEHRRCAEMVNKPTVRGVL
TH_0350|M.thermoresistible__bu RRVTGRSPGRFLRTEIAEPLGAD-VHIGLPHTEHHRCAEMVNKPHIRDVL
Mb2490|M.bovis_AF2122/97 RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
Rv2463|M.tuberculosis_H37Rv RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
MMAR_3810|M.marinum_M RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MUL_3735|M.ulcerans_Agy99 RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MAV_1709|M.avium_104 RRVTGRTIGHYLRTEIAGPFGAD-VHIGLPLAEQHRCAERVNKPHARDLL
MAB_0853|M.abscessus_ATCC_1997 RRTTGKTLGQFLRTEIAEPYGLD-VHVGLPHSEHHRCAELINKPYLRDVF
Mvan_5383|M.vanbaalenii_PYR-1 RRITGTPLKDFVAEQIAVPLGAD-VQIGARPEDDHRIAELVPPP-PRDRG
Mflv_3647|M.gilvum_PYR-GCK RSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARIIGPQTRLQN
MLBr_00119|M.leprae_Br4923 WTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVP----------LVALS
** : :: * . :.* :
MSMEG_4680|M.smegmatis_MC2_155 ADFGLP-RPTSLDDHPMAGFAVSMDFVPDDELGVHDLSAWRTAEFPSTNG
TH_0350|M.thermoresistible__bu AAGGAPAHPERLDEHPMAGLAVAMGFIPDDELGSADLTGWRAAEFPATNG
Mb2490|M.bovis_AF2122/97 ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
Rv2463|M.tuberculosis_H37Rv ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
MMAR_3810|M.marinum_M ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MUL_3735|M.ulcerans_Agy99 ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MAV_1709|M.avium_104 ADANAPTDPRSLAEHPKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNG
MAB_0853|M.abscessus_ATCC_1997 R--GAPGEFDCMSDHPLAGPLISGDFIPDDEIARKDIALWRALEFPGTNA
Mvan_5383|M.vanbaalenii_PYR-1 VDRLPPDHPAVKTFAAFPPGAYGAAHAETEAWRRADIG--GANGHGNARG
Mflv_3647|M.gilvum_PYR-GCK PIFNAVAPHIAALPFSAG---FGAMYFPGVKSFVQGDTPLLDGEIPAANG
MLBr_00119|M.leprae_Br4923 HATGRPLPPIIAAIFRKAIGGTVHEVIPYTNTPPFLTTIVPSSNTVSTAN
:
MSMEG_4680|M.smegmatis_MC2_155 HVSALGMATFYN-ALAQEKLLS--RELMERCRVSQGGFDTDLVLGPRVAD
TH_0350|M.thermoresistible__bu HVSAVGLATVYH-ALAREQLIS--RGHLERCRMSQGGFDPDLVLGPRVAD
Mb2490|M.bovis_AF2122/97 QVSALGLATFYN-GLAQEKLLS--REHMELVRVSQGGFDTDLVLGPRVAD
Rv2463|M.tuberculosis_H37Rv QVSALGLATFYN-GLAQEKLLS--REHMELVRVSQGGFDTDLVLGPRVAD
MMAR_3810|M.marinum_M QVSALGLATFYN-ALAQEKLLS--REHMDLVRVSQGGFDTDLVLGPRVAD
MUL_3735|M.ulcerans_Agy99 QVSALGLATFYN-ALAQEKLLS--REHMDLVRVSQGGFDTDLVLGPRVAD
MAV_1709|M.avium_104 QVSALGLATFYN-ALAQEKLLS--REHMDRVRVCQGGLDTDLVLGPRVAD
MAB_0853|M.abscessus_ATCC_1997 HVSALGMATFYN-AMALGKLLS--HEHMDVVRVSQGGFDPDVVLGPRVAN
Mvan_5383|M.vanbaalenii_PYR-1 LVRALSPISLGG-TANGVQVVD--PRTVELIFAEQSSGMDQVLFVP--LR
Mflv_3647|M.gilvum_PYR-GCK VATARALARMYG-AIANEGRIDGLQYLSRETTAVLAGRRSLRLDHSMVMP
MLBr_00119|M.leprae_Br4923 ELSRFAEIWLRGGELDGIRVLR--SETLLGAVAECRRLRPDFVVGLMPAR
. . : :
MSMEG_4680|M.smegmatis_MC2_155 HGWGLGYMLNQRGVAGPNR-RTFGHGGSGGSFAFVDLEHRIGYAYVMNHF
TH_0350|M.thermoresistible__bu HGWGLGYMLNQRGHAGPNR-RVFGHGGSGGSFGFADLEHRIGYAYVMNNF
Mb2490|M.bovis_AF2122/97 HGWGLGYMLNQRGVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
Rv2463|M.tuberculosis_H37Rv HGWGLGYMLNQRGVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MMAR_3810|M.marinum_M HGWGLGYMLNQRAVNGPNQ-KIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MUL_3735|M.ulcerans_Agy99 HGWGLGYMLNQRAVNGPNQ-KIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MAV_1709|M.avium_104 HGWGLGYMLNQRCVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MAB_0853|M.abscessus_ATCC_1997 HGWGLGYMLNQRCYAGPNQ-KTFGHGGSGGSYAFVDLEHRIGYSYVMNQF
Mvan_5383|M.vanbaalenii_PYR-1 FGIGFGLPTPQSVPAVPDG-KVCWWGGWGGSLVVMDLDRRATFAYVMNKM
Mflv_3647|M.gilvum_PYR-GCK LSFHLGYHGLPIPGLLPG----FGHVGLGGSLGWADPETGLAFGFVHNRL
MLBr_00119|M.leprae_Br4923 WGTGFILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRSMAAGLISSGK
. : . * . * : . : .
MSMEG_4680|M.smegmatis_MC2_155 DATKCNADPRTVALSNQVYSALGVI------------------------
TH_0350|M.thermoresistible__bu DATKAHADPRSVALSDAVYSALGVTAHRSAAPVGAAGRR----------
Mb2490|M.bovis_AF2122/97 DATKANADPRSVVLSNEVYAALGVNRS----------------------
Rv2463|M.tuberculosis_H37Rv DATKANADPRSVVLSNEVYAALGVNRS----------------------
MMAR_3810|M.marinum_M DASKANADPRSVALSNEVYAALDVAAD----------------------
MUL_3735|M.ulcerans_Agy99 DASKANADPRSVALSNEVYAALDVAAD----------------------
MAV_1709|M.avium_104 DATKANADPRSLALSNEVYSVLGVR------------------------
MAB_0853|M.abscessus_ATCC_1997 DVTKADADPRSVRLINELYTTLGVSPAGESL------------------
Mvan_5383|M.vanbaalenii_PYR-1 GG-GTTGTPRTVRYAKLIDAALQDARG----------------------
Mflv_3647|M.gilvum_PYR-GCK LTPMVVSDQAGFVATAALLRRGASQARKNGYRRVREYGSPFSDVAATAV
MLBr_00119|M.leprae_Br4923 PGQDPNAG-RYGALMNTITAEIPVH------------------------
. :