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MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAGGTRQLSPYML MMPLMMIVMMVGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSI VGTQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGELAAASAAPQPFLEPVSHMWVVKFLRTHGLI HDCPKLLQLRTFPTIAIGGDLAGAAGLMTAMICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQ TETDAAGSTRLIFTRQEGLSDLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPDGRAGVTVITLGNHRGS AYRIRVHEDGTADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQL VGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGTTGSGKSEFLR TLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAELVSRMGEVLTGELDRRQSILR QAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHLL LATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFY ISGPYMPPAAGVETNGEAGGPGQQTTRQAARIHRFTAAPVLEEAPTP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3870 | - | - | 100% (747) | POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN |
M. tuberculosis H37Rv | Rv3447c | - | e-116 | 37.74% (742) | hypothetical protein Rv3447c |
M. tuberculosis H37Rv | Rv0284 | - | 1e-94 | 32.92% (720) | hypothetical protein Rv0284 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3900 | - | 0.0 | 100.00% (747) | hypothetical protein Mb3900 |
M. gilvum PYR-GCK | Mflv_0771 | - | 0.0 | 80.32% (747) | cell divisionFtsK/SpoIIIE |
M. leprae Br4923 | MLBr_00053 | - | 0.0 | 85.39% (746) | hypothetical protein MLBr_00053 |
M. abscessus ATCC 19977 | MAB_3756c | - | 1e-135 | 39.34% (755) | putative FtsK/SpoIIIE family protein |
M. marinum M | MMAR_5445 | - | 0.0 | 89.56% (747) | hypothetical protein MMAR_5445 |
M. avium 104 | MAV_4390 | - | 1e-106 | 36.54% (739) | ftsk/SpoIIIE family protein |
M. smegmatis MC2 155 | MSMEG_0061 | - | 0.0 | 80.91% (744) | ftsk/SpoIIIE family protein |
M. thermoresistible (build 8) | TH_4195 | - | 0.0 | 83.02% (742) | PUTATIVE cell divisionFtsK/SpoIIIE |
M. ulcerans Agy99 | MUL_0860 | - | 1e-106 | 36.66% (731) | hypothetical protein MUL_0860 |
M. vanbaalenii PYR-1 | Mvan_0074 | - | 0.0 | 79.78% (742) | cell divisionFtsK/SpoIIIE |
CLUSTAL 2.0.9 multiple sequence alignment Rv3870|M.tuberculosis_H37Rv MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAM Mb3900|M.bovis_AF2122/97 MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAM MMAR_5445|M.marinum_M MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAM MLBr_00053|M.leprae_Br4923 MTTKKFTPTITRGPRLTPGEINITPPDDLGLEIPPSGIQKILPYVMVGCI MSMEG_0061|M.smegmatis_MC2_155 MTTKKFTPTIKRGPRLTPGEINVAPPDDLGIDIPPSGMQKALPWVMGGCM TH_4195|M.thermoresistible__bu MTTRKFTPTIKRGPRLTPGEINVTPPEDLGVEIPPSGVQKALPWVMGGCM Mflv_0771|M.gilvum_PYR-GCK MTTRKFTPIIKRGPRLTPGEINVAPPEDLGVDIPPSGMQKALPWVMGGCM Mvan_0074|M.vanbaalenii_PYR-1 MTTRKFTPIIKRGPRLTPGEINVTPPEDLGVDIPPSGMQKALPWVMGGCM MAV_4390|M.avium_104 ---------------MTQADIVVEAPPELPAPESTGLPARLLPVALSVAG MUL_0860|M.ulcerans_Agy99 ----------------MTEDLVVAAPPELAQTTSTGPLLRLVPLAMSIAT MAB_3756c|M.abscessus_ATCC_199 ---------------MPGGEVNVQPPPEIPRPVPSPIIAKIMPLVMVVAM :: : .* :: .. : :* .: . Rv3870|M.tuberculosis_H37Rv LGMIAIMVAGG--------TRQLSPYMLMMPLMMIVMMVGGLAGSTGGGG Mb3900|M.bovis_AF2122/97 LGMIAIMVAGG--------TRQLSPYMLMMPLMMIVMMVGGLAGSTGGGG MMAR_5445|M.marinum_M LGMIVIMVAGG--------TRQLSPYMLMMPLMMIVMMVGTLAGGSGGGS MLBr_00053|M.leprae_Br4923 VGMIAIMVLGG--------TKQLSPYMLMMPIMMVMMMAGGSGG--GGGG MSMEG_0061|M.smegmatis_MC2_155 LGMIAIMVFTG--------VRQLSPYMLMMPLMMIMGTVGFMAGG-GSGG TH_4195|M.thermoresistible__bu LGMIAIMVFTG--------IRNLSPYMLMMPLMMVMATVGFMAGG-GPGG Mflv_0771|M.gilvum_PYR-GCK LGMIAILIFGG--------LRNFSPYMLMMPMMVVMGAVGMMASG-GSGG Mvan_0074|M.vanbaalenii_PYR-1 LGMIAILIFGG--------MRNFSPYMLMMPMMVVMGAVGMMAGG-GSGG MAV_4390|M.avium_104 IGVMTVVFASG-------GAAARQPAFLAFPATMLVSTVAAALIG-RSR- MUL_0860|M.ulcerans_Agy99 LIAMAATYVSG-------APSARNPTMLVLPATMSLSLMVMAVSA-RGR- MAB_3756c|M.abscessus_ATCC_199 VGMIAFFVTSGSFGGGAGGGMMRSPMFMLFPIMMMVSMVSMVSNS-GGKG : :. * .* :: :* : : Rv3870|M.tuberculosis_H37Rv KKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVG Mb3900|M.bovis_AF2122/97 KKVPEINADRKEYLRYLAGLRTRVTSSATSQVAFFSYHAPHPEDLLSIVG MMAR_5445|M.marinum_M KKVPEINADRKEYLRYLAGLRGRVTTSATSQVSFFGYHAPHPDDLLSIVG MLBr_00053|M.leprae_Br4923 KKVPEINADRKEYLRYLAGLRARVTSSAASQVAFFSYHAPHPQDLLSIVG MSMEG_0061|M.smegmatis_MC2_155 KKVPEINADRKEYLRYLAGLRTRVTSSASAQVAFFAYHAPHPDDLLSIIG TH_4195|M.thermoresistible__bu KRVPEINADRKEYLRYLAGLRNRVTSSAAAQVTFFAYHAPHPDDLLSIVG Mflv_0771|M.gilvum_PYR-GCK KKVPEINADRKEYLRYLAGLRTRVTSSAAAQVSFFNYHAPHPDDLLSIVG Mvan_0074|M.vanbaalenii_PYR-1 KKVPEINADRKEYLRYLAGLRTRVTSSASAQVTFFNYHGPHPDDLLSIIG MAV_4390|M.avium_104 RGGGGLDADRGRYLEYLNQLGRSVSEIAAAQCASALRDHPDPDTLWTLIG MUL_0860|M.ulcerans_Agy99 RRGAGLDQDRVGYLQYLSELRQRVTEIAAAQRISSNRTHPEPDTVWTLIG MAB_3756c|M.abscessus_ATCC_199 AKTSEINEDRKDYLRYLEVVRKNVTDTGAAQRKALLWNNPDPSALWTLAG :: ** **.** : *: .::* *.*. : :: * Rv3870|M.tuberculosis_H37Rv TQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGELAAASAAPQPFL Mb3900|M.bovis_AF2122/97 TQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGELAAASAAPQPFL MMAR_5445|M.marinum_M TQRQWSRPANSDFYAAARIGIGDQPAVDRLLKPAVGGELAASSAAPQPYL MLBr_00053|M.leprae_Br4923 TQRQWSRPANADFYAATRIGVGDQPAVDRLLKPAVGGELTASGAAPQPFL MSMEG_0061|M.smegmatis_MC2_155 THRQWARQANSEFFAATRIGIGAEIAVDRLLKPNTSGELAGGQAAPAPHL TH_4195|M.thermoresistible__bu THRQWSRQTNADFYAAVRIGIGSEPAVDRLLKPSVGAELVGPQGAPQPHL Mflv_0771|M.gilvum_PYR-GCK THRQWSRAANHDFYAATRIGLGSEPAVDRLLKPAVGAELAGPAGAPQPHL Mvan_0074|M.vanbaalenii_PYR-1 THRQWSRPANHDFYAATRIGLGSEPAVDRLLKPAVGSELAGPAGAPQPHL MAV_4390|M.avium_104 GPRMWRRRPTGPDFCVVRVGMGVLPLARRVVAPPVP---------AEEVR MUL_0860|M.ulcerans_Agy99 GSRMWERRPADADFCRIRIGLGTQPLATRLVAAPLP---------PPHRS MAB_3756c|M.abscessus_ATCC_199 GRRMWERRPGDSDYCHVRVGTGDQRLAAQLVAPEIG---------PVEEL * * * . :. *:* * . ::: . . Rv3870|M.tuberculosis_H37Rv EPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTAMI Mb3900|M.bovis_AF2122/97 EPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTAMI MMAR_5445|M.marinum_M EPVSHMWVVKFLRTHGLIHDCPKLVQLRSFPTIAIGGDRPGADRLLTAMI MLBr_00053|M.leprae_Br4923 EPVSHMWVVKFLRTHGLVHDCPKLLQMRTFPTIAVGGDTAGAGGLLTAMI MSMEG_0061|M.smegmatis_MC2_155 EPVSHMWVTKFLRTHGLIHDCPKLVQLRTFPTVAVGGDPEAAEGLLTSMI TH_4195|M.thermoresistible__bu EPVSHMWVTKFLRTHGLIHDCPKLVQLRTFPTIAIGGDPEGAARLLTAMI Mflv_0771|M.gilvum_PYR-GCK EPVSHMWVTKFLRTHGLIHDCPKLLQLRTFPTIAVGGDTDGAVGLLTAMI Mvan_0074|M.vanbaalenii_PYR-1 EPVSHMWVTKFLRTHGLIHDCPKLVQLKTFPTIAVGGDSAGSAALLAAMI MAV_4390|M.avium_104 DPVTATALRRFLHTHATVPG-PVTVDLGAGSPVTIDGDAGAARAVLRAVV MUL_0860|M.ulcerans_Agy99 DPVTVSALRRFLEAHARVTDVPIAIALHGAGVVTIGGDPARVRALLRAMV MAB_3756c|M.abscessus_ATCC_199 EPVASVALRRFVRTHSLVPELPIALNLRGFAAVTIDGSPEVARGMLRAMI :**: : :*:.:*. : * : : :::.*. :: ::: Rv3870|M.tuberculosis_H37Rv CHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLI Mb3900|M.bovis_AF2122/97 CHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLI MMAR_5445|M.marinum_M CHLAVFHPPDLLQIRVLTEDPEDPDWSWLKWLPHVQHQTETDGAGPVRMI MLBr_00053|M.leprae_Br4923 CHLAVFHPPDLLQIRVLTEKPDDPNWSWLKWLPHIQHPTETDAAGAARMI MSMEG_0061|M.smegmatis_MC2_155 CHLAVFHPPDLVQIRVLTDNPEDPKWSWLKWLPHTQHQTDTDAAGPTRLV TH_4195|M.thermoresistible__bu CHLAVFHPPDLLQIRVLTDNPEDPEWSWIKWLPHVQHPTDTDAAGPTRMV Mflv_0771|M.gilvum_PYR-GCK CHLAVFHPPDMLQMRVLTDNPEDPVWAWLKWLPHLQHQTDTDAAGATRMV Mvan_0074|M.vanbaalenii_PYR-1 CHLAVFHPPDMLQMRVLTDDPEDPAWAWLKWLPHLQHETDTDAAGTTRMV MAV_4390|M.avium_104 CQLAVLHAPDRVGIAAVVGDGDRAHWDWLKWLPHNRHPTHDDALGPMRMV MUL_0860|M.ulcerans_Agy99 CQMAVLHGPDQLLVAAVVSDRNRPGWEWLKWLPHNQHPSHHDEVGAERMV MAB_3756c|M.abscessus_ATCC_199 CQLAMFHGPDQFLVAAVVNRHAAPHWDWLKWLPHSQHPSAFDGVGTSRLV *::*::* ** . : .:. . * *:***** :* : * *. *:: Rv3870|M.tuberculosis_H37Rv FTRQEGLSDLAARGPHAPDSLPGGPYVVVVDLTG-----------GKAGF Mb3900|M.bovis_AF2122/97 FTRQEGLSDLAARGPHAPDSLPGGPYVVVVDLTG-----------GKAGF MMAR_5445|M.marinum_M STRPDGLADLAARGPHAPDTLPTGPYVVVLDLTG-----------GKAGF MLBr_00053|M.leprae_Br4923 FTRSDSLADLMSRGPHAPDSLPGGPYVILVDLTG-----------GKAGF MSMEG_0061|M.smegmatis_MC2_155 YTRPDGLSDLTARGPHTADAAPGGPYVVVVDLTG-----------GKAGF TH_4195|M.thermoresistible__bu FTRPDGLSDLAARGPHTADSAPSGPYVVVVDLTG-----------GKAGF Mflv_0771|M.gilvum_PYR-GCK FTRTDGLSDLAARGPHTADATPSGPYVVVIDLTG-----------GRAGF Mvan_0074|M.vanbaalenii_PYR-1 FTRPDALSDLAARGPHTADAAPSGPYVVVIDLTG-----------GRAGF MAV_4390|M.avium_104 YSTAAQAQQALAG--LPVARLVLVAERAVAPI------------------ MUL_0860|M.ulcerans_Agy99 YPNITQASAAFDAVALPVMVIVDTDEHGKQLP------------------ MAB_3756c|M.abscessus_ATCC_199 YHSLGEVEESLASLITERERFSRTAQPSPDRPQILIVVDSGTLIGSERLI Rv3870|M.tuberculosis_H37Rv PPDGRAGVTVITLGNHRGSAYRIRVHE-DGTADDRLP-NQSFRQVTSVTD Mb3900|M.bovis_AF2122/97 PPDGRAGVTVITLGNHRGSAYRIRVHE-DGTADDRLP-NQSFRQVTSVTD MMAR_5445|M.marinum_M PPDGRAGVTVITLGNHRGSAYRIRVAE-NGTADDRLP-GQQFRLVTAAAD MLBr_00053|M.leprae_Br4923 PPDGRAGVTVITLGNHRSSTYRIRVNK-NGTADDRLP-GQSFRQVTSTVD MSMEG_0061|M.smegmatis_MC2_155 PPDGRAGVTVITLGAQRQAAYKLKVEK-DGKAEDRLP-NQPWREVTRVAD TH_4195|M.thermoresistible__bu PVDGRAGVTVLTLGNHRGSNYRIRVAA-DGTADDRLP-GQSFRLVTSVAD Mflv_0771|M.gilvum_PYR-GCK PMDGRSGVTVLTLGNHR-STYRIRVDAGDGTADDKLP-GASFRLVASEVD Mvan_0074|M.vanbaalenii_PYR-1 PMDGRSGVTVITLGNHR-SAYRIRVDA-DGTADDKLP-GASFRLVASQVD MAV_4390|M.avium_104 -----AGATVIAIGAGDD------GAPVTIRT-------AAGTVSPSRPD MUL_0860|M.ulcerans_Agy99 -----AGVTVLEVGRGPD------GTQVVVKR-------AGETTTLTRPD MAB_3756c|M.abscessus_ATCC_199 VDHGIDSVTLVEIGTRVDPLAARRGMQLELTERGLGAKGNVGSEVFAHPD ..*:: :* * Rv3870|M.tuberculosis_H37Rv RMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQLVGAQSVEEI Mb3900|M.bovis_AF2122/97 RMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQLVGAQSVEEI MMAR_5445|M.marinum_M SMTPQEATRLARKLAGWSITGTILDKTQRIQKKVATEFHQLVNAKSVEDI MLBr_00053|M.leprae_Br4923 HLSKAEATRIARKLAGWSITGTILDKTSRVQKKVATEWHQLVGANTVEEV MSMEG_0061|M.smegmatis_MC2_155 RMTPGQAGRIARKLAGWSITGTIIDKNVRVQKKVSNEWHHLVGAQSVEEV TH_4195|M.thermoresistible__bu RMTPEQAGHVARKLAGWSITGTIIDKNVRVQKKVATEWHQLVGAQSVEEV Mflv_0771|M.gilvum_PYR-GCK RMSPAQAERLARKLAGWSITGTIIDKGTRVQKKVATEWHEIVGAQSVEEV Mvan_0074|M.vanbaalenii_PYR-1 GMTPRQAERVARKLAGWSITGTIIDKGTRVQKKVATEWHEIVGAQSVEEV MAV_4390|M.avium_104 RMTAADALTCARRLAGQRV--TAGDG--------DGGWPGLVGLADVSGF MUL_0860|M.ulcerans_Agy99 ELDQVSALVCARLLAPHRCGDRAGGH--------PGDWARMLGIGEIATY MAB_3756c|M.abscessus_ATCC_199 HLTITEAMACARRLAPYRVLTGSGDEVQ-IQTEVSTRWSDIVGIGDPGLL : .* ** ** . : ::. Rv3870|M.tuberculosis_H37Rv TPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIG Mb3900|M.bovis_AF2122/97 TPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIG MMAR_5445|M.marinum_M TPGRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGGGPHGMLIG MLBr_00053|M.leprae_Br4923 LPSRWRMYTDNDRDRLKIPFGHEFKTGNIMYLDIKEGAEFGGGPHGMLIG MSMEG_0061|M.smegmatis_MC2_155 TPARWRMYADTDRDRLKIPFGHELKTGEIMYLDIKEGAEFGAGPHGMLIG TH_4195|M.thermoresistible__bu TPARWRMFADTDRDRLRIPFGHELKTGEIMYLDIKEGAEFGAGPHGMLIG Mflv_0771|M.gilvum_PYR-GCK TPARWRMFTDTDRDRLRIPFGHELKTGDVMYLDIKEGAEFGAGPHGMLIG Mvan_0074|M.vanbaalenii_PYR-1 TPARWRMFTDTDRDRLRIPFGHELKTGDVMYLDIKEGAEFGAGPHGMLIG MAV_4390|M.avium_104 DPATLWGRQ-TGRDRLRAPLGVAAD-GTPVELDIKEPAEHGMGPHGLCVG MUL_0860|M.ulcerans_Agy99 HPVSHWHKR-NQRERLCVPIGATAD-GSPVLLDIKEPAARGMGPHGLCIG MAB_3756c|M.abscessus_ATCC_199 NPEVVWRNR-VGRDRLRVPIGIAVD-GTPMELDIKEAAENGMGPHGLCIG * *:** *:* . * : ***** * * ****: :* Rv3870|M.tuberculosis_H37Rv TTGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAA Mb3900|M.bovis_AF2122/97 TTGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAA MMAR_5445|M.marinum_M TTGSGKSEFLRTMILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAA MLBr_00053|M.leprae_Br4923 TTGSGKSEFLRTLILSLVAMTHPNQVNLLLTDFKGGSTFLGMEKLPHTAA MSMEG_0061|M.smegmatis_MC2_155 TTGSGKSEFLRTLILSLVATHHPDQINLLLTDFKGGSTFLGMEKLPHTAA TH_4195|M.thermoresistible__bu TTGSGKSEFLRTLILSLAATHHPDQVNLLLTDFKGGSTFLGMEKLPHTAA Mflv_0771|M.gilvum_PYR-GCK TTGSGKSEFLRTLILSLAATHHPDQINLLLTDFKGGSTFLGMEKLPHTAA Mvan_0074|M.vanbaalenii_PYR-1 TTGSGKSEFLRTLILSLAATHHPDQINLLLTDFKGGSTFLGMEKLPHTAA MAV_4390|M.avium_104 ATGSGKSELLRTIALGMMARNSPDVLNLLLVDFKGGATFLDYANAPHVAA MUL_0860|M.ulcerans_Agy99 ATGSGKSELLRTVALGMMVGNSPEVLNLLLIDFKGGATFLDLEKAPHVAA MAB_3756c|M.abscessus_ATCC_199 ATGSGKSEFLRTLTLGMIATHSPDALNLVLVDFKGGATFLGLDRAQHVAA :*******:***: *.: . *: :**:* *****:***. . *.** Rv3870|M.tuberculosis_H37Rv VVTNMAEEAELVSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYE Mb3900|M.bovis_AF2122/97 VVTNMAEEAELVSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYE MMAR_5445|M.marinum_M VITNMAEEAELVSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYE MLBr_00053|M.leprae_Br4923 VVTNMAEEAELVSRMGEVLTGELDRRQNILRQAGTLVGAAGALSGVAEYE MSMEG_0061|M.smegmatis_MC2_155 VVTNMEEEAELVSRMGEVLTGELDRRQSILRQAGMQVGAAGALSGVAEYE TH_4195|M.thermoresistible__bu VVTNMEEEAELVSRMGEVLTGELDRRQSILRQAGMQVGAAGALSGVAEYE Mflv_0771|M.gilvum_PYR-GCK VVTNMEEEAELVSRMGEVLTGELDRRQSILRQAGIQVGAAGALSGVAEYE Mvan_0074|M.vanbaalenii_PYR-1 VVTNMEEEAELVSRMGEVLTGELDRRQSILRQAGMQVGAAGALSGVAEYE MAV_4390|M.avium_104 VITNLADDAPLVARMRAALAGEMNRRQEALR-------TAG-CDSVAAYQ MUL_0860|M.ulcerans_Agy99 VITNLADQAPLVARMGEALAGEMNRRQHLLR-------TAGNFVSVAAYE MAB_3756c|M.abscessus_ATCC_199 IITNLAEEANLVSRMKDALAGEMNRRQELLR-------AAGNFANVTEYE ::**: ::* **:** .*:**::*** ** :** .*: *: Rv3870|M.tuberculosis_H37Rv KYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHL Mb3900|M.bovis_AF2122/97 KYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHL MMAR_5445|M.marinum_M KYRERGADLPPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHL MLBr_00053|M.leprae_Br4923 KYRERGANLAPLPTLFVVVDEFAELLQSHPDFIGLFDRICRVGRSLRVHL MSMEG_0061|M.smegmatis_MC2_155 KHRERGADLPPLPTLFVVVDEFAELLQNHPDFINLFDRICRVGRSLRVHL TH_4195|M.thermoresistible__bu KYRERGADLPPLPTLFVVVDEFAELLQNHPDFINLFDRICRVGRSLRVHL Mflv_0771|M.gilvum_PYR-GCK KHRERGADLPPLPTLFVVVDEFAELLQNHPDFIGLFDRICRVGRSLRVHL Mvan_0074|M.vanbaalenii_PYR-1 KHRERGADLAPLPTLFVVVDEFAELLQNHPDFIQLFDRICRVGRSLRVHL MAV_4390|M.avium_104 HARRSAAALPALPTLFVIVDEFSELLSQQPDFADTFVAIGRLGRSLGIHL MUL_0860|M.ulcerans_Agy99 DARRRGAGLAALPTLFIIVDEFAELLSQHPDFAEVFVAIGRLGRSLGMHL MAB_3756c|M.abscessus_ATCC_199 RARAAGASLSPLPALFIIVDEFSELLSQHPDFAELFVAIGRLGRSLHVHL * .* *..**:**::****:***..:*** * * *:**** :** Rv3870|M.tuberculosis_H37Rv LLATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNK Mb3900|M.bovis_AF2122/97 LLATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNK MMAR_5445|M.marinum_M LLATQSLQTGGVRIDKLEPNLTYRIALRTTSSHESKAVIGTPEAQYITNK MLBr_00053|M.leprae_Br4923 LLATQSLQTGGVRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNK MSMEG_0061|M.smegmatis_MC2_155 LLATQSLNTGGVRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNK TH_4195|M.thermoresistible__bu LLATQSLNTGGVRIDKLEPNLTYRIALRTTSSTESKAVIGTPEAQYITNK Mflv_0771|M.gilvum_PYR-GCK LLATQSLNTGGTRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNK Mvan_0074|M.vanbaalenii_PYR-1 LLATQSLNTGGTRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNK MAV_4390|M.avium_104 LLASQRLDEG--RLRGLDAHLSYRLCLKTLSEAESRAVLGNLDAYHLPT- MUL_0860|M.ulcerans_Agy99 LLASQRLEEG--RLRGLEAHLSYRVCLKTLSAIESRTALGTLDAFELPN- MAB_3756c|M.abscessus_ATCC_199 LLASQRLDEG--RLRGLESHLSYRLCLKTFSANESRAAIGVPDAYHLPN- ***:* *: * *: *:.:*:**:.*:* * **::.:* :* :.. Rv3870|M.tuberculosis_H37Rv ESGVGFLRVGMEDPVKFSTFYISGPYMP---------------------- Mb3900|M.bovis_AF2122/97 ESGVGFLRVGMEDPVKFSTFYISGPYMP---------------------- MMAR_5445|M.marinum_M ESGVGFLRVGMEDPIKFSTLYISGPYVP---------------------- MLBr_00053|M.leprae_Br4923 ESGVGFLRIGMEDPVKFSSLYTGIPFVP---------------------- MSMEG_0061|M.smegmatis_MC2_155 ESGVGFLRVGMEDPVKFRSVYTGNNYVP---------------------- TH_4195|M.thermoresistible__bu ESGVGFLRVGMEDPVKFRTVYTGNPYVP---------------------- Mflv_0771|M.gilvum_PYR-GCK ESGVGFLRVGMEDPVKFQSVYTGTPYVP---------------------- Mvan_0074|M.vanbaalenii_PYR-1 ESGVGFLRVGMEDPVKFQSVYTGNPYVP---------------------- MAV_4390|M.avium_104 DPGAGYLRVGAGAPIRFQAALVSGPLRPDTAPRP-------PAMVRVFGT MUL_0860|M.ulcerans_Agy99 TPGSGLLSSPTAELTRFETAFVSGPVPAGPPDADSVAL---PAAVRPFTS MAB_3756c|M.abscessus_ATCC_199 TPGSCYLKDDSGELTRFQTSYVSGPYVPYGPARRTVSSGGGGAAPRLFTA .* * :* : . . Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 RVVG------PVSR--PVEAAHPSGRSISAAVLDRLAGHGPAAHRVWLPP MUL_0860|M.ulcerans_Agy99 EATG------DVRTGGADGADTATGPTVLQTVLDRIAGHGPRAHQVWLPP MAB_3756c|M.abscessus_ATCC_199 APVALQMRPAEVVEDDSPAVSEATGRSVIDTILDRVEGHGNPAHEVWLPP Rv3870|M.tuberculosis_H37Rv -------------------------------------------PAAGVET Mb3900|M.bovis_AF2122/97 -------------------------------------------PAAGVET MMAR_5445|M.marinum_M -------------------------------------------PAT-AET MLBr_00053|M.leprae_Br4923 -------------------------------------------AIA-TET MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------AAP---E TH_4195|M.thermoresistible__bu -------------------------------------------HSS---A Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------VTV---G Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------TVG---N MAV_4390|M.avium_104 LGRPPELRTLLGG--------AADLTVPVGLVDRPFEQCRTPLIVDLSGA MUL_0860|M.ulcerans_Agy99 LDRAPALASLLSDGAAE----HAELAVPIGVVDRPFDQSRTPLTIDLTAA MAB_3756c|M.abscessus_ATCC_199 LDDSPTLGDLIPRHGRAGFDAVGSLTVPIGIVDRPYEQRRDPYIVDLSAA Rv3870|M.tuberculosis_H37Rv NGEAGGPGQQTTRQAARIHRFTAAPVLEEAPTP----------------- Mb3900|M.bovis_AF2122/97 NGEAGGPGQQTTRQAARIHRFTAAPVLEEAPTP----------------- MMAR_5445|M.marinum_M NGDGSGPSTQFAKRALQIREFTAAPVLEEALTP----------------- MLBr_00053|M.leprae_Br4923 NGDSSPSSPWASRKKVHIYEFTAAPILESTTTS----------------- MSMEG_0061|M.smegmatis_MC2_155 SSDREAKPKAQRQSQVRIHQFTTTPIFDTAVS------------------ TH_4195|M.thermoresistible__bu SENGEARPRVPERQRVRIREFTCAPIPEAMVN------------------ Mflv_0771|M.gilvum_PYR-GCK AGD-DDTPRAHADSGIRIHRFTTAPIADTRVTV----------------- Mvan_0074|M.vanbaalenii_PYR-1 AGD-DEAPKAHADKNIRIHRFTTAPIMDARLG------------------ MAV_4390|M.avium_104 AGNVAVVGAPRSGKSTALRTLITALAATHDPARVQFYCLDFGGGALSSLH MUL_0860|M.ulcerans_Agy99 AGNVAVVGAPQSGKSTTLSTLITALAATHDPDLVQFYCLDFGGGALAAVR MAB_3756c|M.abscessus_ATCC_199 AGNVAIVGAPQSGKSMAVRTLVTSLAVTHSPAQVQFYCLDFGGGTLTSLA : : : : Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 TLPHVGAVAGRAEPRRVGRIVAECEAVVGRREAFFGEHAIASIADYRQRR MUL_0860|M.ulcerans_Agy99 DLPHVGAVAGRGEPDLIRGIVAELESCLRTRESLFGEQGIDSIAAYRRLR MAB_3756c|M.abscessus_ATCC_199 QLPHVGSVASRLESDLIRRTFAEMLTIVRSRENAFRAYGIDSMAEYRRRK Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 ----PGS--DPFGDVFLVIDGWAVLRRDFETLEASIIALAGQGLSFGVHL MUL_0860|M.ulcerans_Agy99 ----ADSGAQRLADLFVVIDGWATLCHEFEELQEPITALAGQGLSYGLHV MAB_3756c|M.abscessus_ATCC_199 GAGDPQLANDPFGDVFFIIDGWSTVRQEFEALEPQVTALAAQGLGFGVHT Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 VLSASRWADIRPALRDQIGTRIELRLGDPADSEIDRRAAAHVPRDSPGRG MUL_0860|M.ulcerans_Agy99 VVSATRWAHLRGSLKDQLGTRIELRLGDPADSEVDRRGARQVPRDRPGRG MAB_3756c|M.abscessus_ATCC_199 VVTASRWAEIRPALKDQIGTRVELRLGDPLDSDFDRKLAQLVPDGRPGRG Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 LSHDGLHMVIASP-VADVAAG------------------ESVAPPIPLLP MUL_0860|M.ulcerans_Agy99 LCDDGMHMMIALPNVAEVVVSQ--------------QHAGSGAPAVPLLP MAB_3756c|M.abscessus_ATCC_199 ITRDRRHMLIGLPRVDSISSNQDLGEAIAAAAASMRQRSSVEAPQVRMLP Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 ARVDLDAVRRGS--GDEFAGRPLLGLQERQLQPLAIDFARESHLLILGAN MUL_0860|M.ulcerans_Agy99 QRVEHRDVVEAA--GAALSGRILLGLQQRRLQPVAVDFEHHAHLLILGDN MAB_3756c|M.abscessus_ATCC_199 HKIDYAALVPQAPQNDQPNLRILVGINESELAPTFLEFGEQPHMMIFGDS Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 GCGKTAALRTLCRELVRTNTAAQAQLVIVDFRRALLGIVESEQLRGYAMS MUL_0860|M.ulcerans_Agy99 ACGKSSALRTLCREITRTKTAAQARLFLVDFRRELLGLSESEYLGGHAIA MAB_3756c|M.abscessus_ATCC_199 ECGKTALLRTMCREIVRTTTPQQAQLFIVDYRRTLLGVVETEHLAKYAMS Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 PAALTALLPGLLDLLSGRMPPPDASQAQLRAGSWWSGPDVYVVVDDYDLV MUL_0860|M.ulcerans_Agy99 AGGLGAFLPGLVELLRARMPAPHLSQARLRDRSWWSGPGIYLMVDDYDLE MAB_3756c|M.abscessus_ATCC_199 SNTLVDEVPALIELLKSRMPGPDVTQQELRDRSWWSGPEIYILVDDYDLV Rv3870|M.tuberculosis_H37Rv -------------------------------------------------- Mb3900|M.bovis_AF2122/97 -------------------------------------------------- MMAR_5445|M.marinum_M -------------------------------------------------- MLBr_00053|M.leprae_Br4923 -------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 -------------------------------------------------- TH_4195|M.thermoresistible__bu -------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_4390|M.avium_104 ASPSGNLLAPLVEFLPYASELGLHLIIARRSGGAERAMFEPLLAGLRDLG MUL_0860|M.ulcerans_Agy99 CTSASNPLLALLEYLPYATDLGLHLIVASRSGGATRALFEPLLAALRDFG MAB_3756c|M.abscessus_ATCC_199 ALASGNPLLPLAEYLPHSKDIGLHVVIARRTSGASRAMFEPMMARMKDLS Rv3870|M.tuberculosis_H37Rv ------------------------------------------------- Mb3900|M.bovis_AF2122/97 ------------------------------------------------- MMAR_5445|M.marinum_M ------------------------------------------------- MLBr_00053|M.leprae_Br4923 ------------------------------------------------- MSMEG_0061|M.smegmatis_MC2_155 ------------------------------------------------- TH_4195|M.thermoresistible__bu ------------------------------------------------- Mflv_0771|M.gilvum_PYR-GCK ------------------------------------------------- Mvan_0074|M.vanbaalenii_PYR-1 ------------------------------------------------- MAV_4390|M.avium_104 CMSLTMS----EAAPFAAAP--PLPPGRGVLTTRAGADELVQVAWSPP- MUL_0860|M.ulcerans_Agy99 CMALMMSGRCDEGPLFGSGRPMPLPPGRAVLVTWAGDERLVQVAWTEPG MAB_3756c|M.abscessus_ATCC_199 CIGLQMSGNKDEGVLLGTVRPSEQPPGRGTLVMRSGGQQLIQVAWSEPQ