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MAGERKVCPPSRLVPANKGSTQMSKAGSTVGPAPLVACSGGTSDVIEPRRGVAIIGHSCRVGTQIDDSRI SQTHLRAVSDDGRWRIVGNIPRGMFVGGRRGSSVTVSDKTLIRFGDPPGGKALTFEVVRPSDSAAQHGRV QPSADLSDDPAHNAAPVAPDPGVVRAGAAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRERTR AKLEEVLQWPAGTIARIRRGEPTEPATNPDASPGLRPADGPASLIAQAVTAAVDGCSLAIAALPATEDPE FTERAAPILADLRQLEAIAVQATRISRITPELIKALGAVRRHHDELMRLGATAPGATLAQRLYAARRRAN LSTLETAQAAGVAEEMIVGAEAEEELPAEATEAIEALIRQIN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3863 | - | - | 100% (392) | HYPOTHETICAL ALANINE RICH PROTEIN |
| M. tuberculosis H37Rv | Rv0023 | - | 4e-07 | 23.36% (244) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1747 | - | 2e-05 | 32.14% (84) | transmembrane ATP-binding protein ABC transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3893 | - | 0.0 | 100.00% (392) | hypothetical protein Mb3893 |
| M. gilvum PYR-GCK | Mflv_0777 | - | 2e-75 | 63.67% (245) | hypothetical protein Mflv_0777 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1298c | - | 1e-26 | 44.52% (146) | hypothetical protein MAB_1298c |
| M. marinum M | MMAR_5438 | - | 1e-141 | 70.92% (392) | putative regulatory protein |
| M. avium 104 | MAV_3010 | - | 2e-07 | 30.77% (117) | ABC transporter, ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_0052 | - | 6e-72 | 63.22% (242) | hypothetical protein MSMEG_0052 |
| M. thermoresistible (build 8) | TH_2085 | - | 3e-72 | 60.00% (260) | HYPOTHETICAL ALANINE RICH PROTEIN |
| M. ulcerans Agy99 | MUL_3149 | - | 2e-06 | 30.77% (104) | transmembrane ATP-binding protein ABC transporter |
| M. vanbaalenii PYR-1 | Mvan_0068 | - | 4e-77 | 65.57% (244) | hypothetical protein Mvan_0068 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3863|M.tuberculosis_H37Rv --------------------------------------------------
Mb3893|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5438|M.marinum_M --------------------------------------------------
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 ------------------MRYDGAERTFAAGNDVVIGRDLRADLRVAHPL
MUL_3149|M.ulcerans_Agy99 MPLQLVPMTQTAAPPVLTVRYNGAERTFAAGHDVVIGRDLRADVRVADPL
Rv3863|M.tuberculosis_H37Rv --------------------------------------------------
Mb3893|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5438|M.marinum_M --------------------------------------------------
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 ISRTHLIVRYEQGRWVAIDNGSLNGLYVNNRRVPMVDINDGTRVNMGNPD
MUL_3149|M.ulcerans_Agy99 ISRVHLLLRFDQGRWIAIDNGSLNGLYINNRRVPVVDIQDGQRVNIGNPD
Rv3863|M.tuberculosis_H37Rv --------------------------------------------------
Mb3893|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5438|M.marinum_M --------------------------------------------------
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 GPALSFEVG-RHQGSAGRPPLTTSIPIVS-TPSGPMTGAAQGQPPGTQRI
MUL_3149|M.ulcerans_Agy99 GPALDFGVGRRQQGSVGRPPPTAVMQVPPPMPSGPWPSQAPPQT-GSHRP
Rv3863|M.tuberculosis_H37Rv --------------------------------------------------
Mb3893|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5438|M.marinum_M --------------------------------------------------
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 SQPQQPASSSFRQPVQSPTGAQPSHPPSGPTRYPS--------SGLQHAP
MUL_3149|M.ulcerans_Agy99 VPPQ-PAPPTTRMPAQPPSGPQHVQPSDQQPQYPSGPQTSRSQTGAQPAP
Rv3863|M.tuberculosis_H37Rv ----------------------------------MAGERKVCPPSRLVPA
Mb3893|M.bovis_AF2122/97 ----------------------------------MAGERKVCPPSRLVPA
MMAR_5438|M.marinum_M --------------------------------MLVSGTRALPPAS--VAA
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 QIYRAPSGHAAPPTTAQPAPAQTGRIGGDSSNLATSMMKILRPGRAGLES
MUL_3149|M.ulcerans_Agy99 QIYRPPAASPAP-----PAPLVVGRAPGETGNIATSMMKILRPGRAAGEL
Rv3863|M.tuberculosis_H37Rv NKGSTQMSKAGSTVGPAPLVACSGGTSDVIEPRRGVAIIGHSCRVGTQID
Mb3893|M.bovis_AF2122/97 NKGSTQMSKAGSTVGPAPLVACSGGTSDVIEPRRGVAIIGHSCRVGTQID
MMAR_5438|M.marinum_M SEESTYMPDAESTARPALRVARGGDSPGLVTP--GHRPVGRGALTNARLD
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 TPGAVKIGRANDNDIVIPEVLASRHHATLIPTPAGTEIHDNRSINGTFVN
MUL_3149|M.ulcerans_Agy99 PPGAVTIGRADDNDIVIPEVLASRHHATLIPTPQGTEIRDNRSINGTFVN
Rv3863|M.tuberculosis_H37Rv DSRISQTHLRAVSDDGRWRIVGNIPRGMFVGGRRGSSVTVS---DKTLIR
Mb3893|M.bovis_AF2122/97 DSRISQTHLRAVSDDGRWRIVGNIPRGMFVGGRRGSSVTVS---DKTLIR
MMAR_5438|M.marinum_M DPVLSQTHVRAVSDGGQRRIVTNSPNGMFVDGTRKSSVAVS---DKTIVR
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 GVRVDSAVLRDGDVVTIGNIDLVFHGGTLARRDQTAAATRTGGLDVRGVT
MUL_3149|M.ulcerans_Agy99 GARVEAALLHDGDVVTIGNIDLIFANGALARREESLLETRTGGLDVHGVT
Rv3863|M.tuberculosis_H37Rv FGDPPGGKALTFEVVRPSDSAAQHGRVQPSADLSDDPAHNAAPVAPDPGV
Mb3893|M.bovis_AF2122/97 FGDPPGGKALTFEVVRPSDSAAQHGRVQPSADLSDDPAHNAAPVAPDPGV
MMAR_5438|M.marinum_M FGDPTGGKALTFEVVRPSNSPEEDSREQRPAEQSDSQTN-----EADPGV
Mflv_0777|M.gilvum_PYR-GCK ---------------------------MTNAEPIDESIG-----APDPGM
Mvan_0068|M.vanbaalenii_PYR-1 ---------------------------MTNAEPVDQSTG-----APDPGM
TH_2085|M.thermoresistible__bu ---------------------------MTDVDLTASPVS-----EVDPGL
MSMEG_0052|M.smegmatis_MC2_155 ---------------------------MTDAE-FDLATG-----EFDVGL
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 WTIENNKTLLDNISLTALPGTLTAIIGPSGAGKSTFARLVAGYTHPTTGT
MUL_3149|M.ulcerans_Agy99 WTIEGNKTLLDNISLAARPGMLTAVIGPSGAGKSTFARLVAGYTHPTNGT
Rv3863|M.tuberculosis_H37Rv VRAG-----AAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRER
Mb3893|M.bovis_AF2122/97 VRAG-----AAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRER
MMAR_5438|M.marinum_M VRAG-----AAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRER
Mflv_0777|M.gilvum_PYR-GCK ARAG-----AAAAARRRELNISQRSLAAGGIINAGALIAFEKGRSWPRER
Mvan_0068|M.vanbaalenii_PYR-1 VRAG-----AAAAARRRELDISQRSLAAEGIINAGALIAFEKGRSWPRER
TH_2085|M.thermoresistible__bu ARAG-----AAAAARRRELNISQRRLAAEGIINAGALIAFEKGRSWPRER
MSMEG_0052|M.smegmatis_MC2_155 VRAG-----AAAAARRRELDISQRSLAADGIINAGALIAFEKGRSWPRER
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 VAFEGHNVHAEYASLRSRIGMVPQDDVVHGQLTVQQALMYAAELRLPPDT
MUL_3149|M.ulcerans_Agy99 VTFEGHNIHAEYASLRSRIGMVPQDDVVHGQLTVRQALMYAAELRLPPDT
Rv3863|M.tuberculosis_H37Rv TR-------AKLEEVLQWPAGTIARIRRGEPTEPATNP------------
Mb3893|M.bovis_AF2122/97 TR-------AKLEEVLQWPAGTIARIRRGEPTEPATNP------------
MMAR_5438|M.marinum_M TR-------AKLEEVLQWPAGTIARIRQGESVAPEPAP------------
Mflv_0777|M.gilvum_PYR-GCK TR-------ARLEEILQWPPGTIAALRRGEPVHPAPTP------------
Mvan_0068|M.vanbaalenii_PYR-1 TR-------ARLEEILQWPPGTIARLRRGEPLRAAPPPP-----------
TH_2085|M.thermoresistible__bu TR-------AKLEQVLRWPPGTIARLRAGEDVGPAGGPATGAQEPSATRT
MSMEG_0052|M.smegmatis_MC2_155 TR-------LKLEEVLRWPPGTIARLRQGGSVPTTSAPVAPPPPP-----
MAB_1298c|M.abscessus_ATCC_199 --------------------------------MPEVVP------------
MAV_3010|M.avium_104 TKEDRAQVVARVLEELEMTQHLHTRVDKLSGGQRKRASVALELLTGPSLL
MUL_3149|M.ulcerans_Agy99 TKEDREHVVARVLEELEMSKHLETRVDKLSGGQRKRASVALELLTGPSLL
.
Rv3863|M.tuberculosis_H37Rv ---DASPGLRPA--------------DGPASLIAQAVTAAVDGCSLAIAA
Mb3893|M.bovis_AF2122/97 ---DASPGLRPA--------------DGPASLIAQAVTAAVDGCSLAIAA
MMAR_5438|M.marinum_M ---EASVEAPTS--------------DGPASLIAQAVAAAVDTCSLAIAA
Mflv_0777|M.gilvum_PYR-GCK ---EARPPASG----------------DEVSLIAQAVITAVHAFGSTISS
Mvan_0068|M.vanbaalenii_PYR-1 ---ESRAPASN----------------DEVSLIAQAVTTAVSAFGSTVAA
TH_2085|M.thermoresistible__bu DQADYRPNAPGSDH--------GG-SDDEVPLVAQAVLAAVNTLDDASEA
MSMEG_0052|M.smegmatis_MC2_155 ---EPPAAAPAPVT--------SVPAADEVPLIAQAVLTAVHTLETTINA
MAB_1298c|M.abscessus_ATCC_199 -D------------------------DGEAPVIVSLVDAAVHMYSSAIDT
MAV_3010|M.avium_104 ILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLL
MUL_3149|M.ulcerans_Agy99 ILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLL
. . ::. : : .
Rv3863|M.tuberculosis_H37Rv LP---------------ATEDPEFTERAAPILAD----------------
Mb3893|M.bovis_AF2122/97 LP---------------ATEDPEFTERAAPILAD----------------
MMAR_5438|M.marinum_M LP---------------APEEPDFTERAAPILAD----------------
Mflv_0777|M.gilvum_PYR-GCK LP---------------PADDAAFIPRVTAILAD----------------
Mvan_0068|M.vanbaalenii_PYR-1 LP---------------PVDDAAFVPRVTAILAD----------------
TH_2085|M.thermoresistible__bu LP---------------DVDHPEFTPRLTKILAD----------------
MSMEG_0052|M.smegmatis_MC2_155 MP---------------PESDPDFVPRVTAILGD----------------
MAB_1298c|M.abscessus_ATCC_199 LP---------------DPSDPEYGERVAVVLSG----------------
MAV_3010|M.avium_104 APGGKTAFCGPPGQIGPAMGTTNWADIFSTVAGDPDGSRARYLARTGPQP
MUL_3149|M.ulcerans_Agy99 APGGKTAFCGPPSQIGPAMGTTNWADIFSTVADDPEGAQARYLAQTGPPP
* . : : : .
Rv3863|M.tuberculosis_H37Rv --------------------LRQLEAIAVQATRISR----------ITPE
Mb3893|M.bovis_AF2122/97 --------------------LRQLEAIAVQATRISR----------ITPE
MMAR_5438|M.marinum_M --------------------LRQLEGIAVQATRISR----------ITPE
Mflv_0777|M.gilvum_PYR-GCK --------------------LRQLEAVAARAARIGR----------VTPA
Mvan_0068|M.vanbaalenii_PYR-1 --------------------LRQLDAVASRAARIGR----------VTPA
TH_2085|M.thermoresistible__bu --------------------LRQLEAVAARAARISR----------VSPR
MSMEG_0052|M.smegmatis_MC2_155 --------------------LRQLEAVASRAARISM----------VTPP
MAB_1298c|M.abscessus_ATCC_199 --------------------LRKLESAISKAAGRSR----------VTPS
MAV_3010|M.avium_104 PPPPAEQPAELG-DPAHTSLVRQFSTIARRQMRLIVSDRGYFVFLALLPF
MUL_3149|M.ulcerans_Agy99 PAPPVERPGELGGDPSHTSLFRQFSTIARRQMRLIISDRGYFIFLAILPF
.*::. : : *
Rv3863|M.tuberculosis_H37Rv LIKALGAVRR-----HHDELMRLGATAPG---------------------
Mb3893|M.bovis_AF2122/97 LIKALGAVRR-----HHDELMRLGATAPG---------------------
MMAR_5438|M.marinum_M LIKALGAVRR-----YHDKLMTLSATAPG---------------------
Mflv_0777|M.gilvum_PYR-GCK LIKALSTVRG-----LYDDLMLRAAGAPQ---------------------
Mvan_0068|M.vanbaalenii_PYR-1 LIKALSAVRG-----LYDDLMVRAARAPH---------------------
TH_2085|M.thermoresistible__bu VIKALSAVRR-----SIDELTLRGARAPQ---------------------
MSMEG_0052|M.smegmatis_MC2_155 LIKALSAVRR-----QIDELTMRAANAPG---------------------
MAB_1298c|M.abscessus_ATCC_199 VIVALSGVRH-----RYDDLMKAAANSPS---------------------
MAV_3010|M.avium_104 IMGSLSMSVPGDVGFGIPNPMGAAPNEPGQILVLLNVGAVFMGTALTIRD
MUL_3149|M.ulcerans_Agy99 VMGSLSMSVPGDVGFGMPNPMGNAPNEPGQILVLLNVGAVFMGTALTIRD
:: :*. . .. *
Rv3863|M.tuberculosis_H37Rv -------------ATLAQRLYAARRRANLSTLETAQAAGVAEEMIVGAE-
Mb3893|M.bovis_AF2122/97 -------------ATLAQRLYAARRRANLSTLETAQAAGVAEEMIVGAE-
MMAR_5438|M.marinum_M -------------ATLAQRLYAARRRANLSTSETAQAAGVTEELIVRAE-
Mflv_0777|M.gilvum_PYR-GCK -------------AGLGHRLYAARRGANLTVLETAQAAGVSERAIEQAE-
Mvan_0068|M.vanbaalenii_PYR-1 -------------ATLGQRLYAARRGANLTVLETAQAAGVSEDAVQQAE-
TH_2085|M.thermoresistible__bu -------------ATLGQRLYAARRGANLTIEETAQAAGVPAEVIIAAE-
MSMEG_0052|M.smegmatis_MC2_155 -------------ATLGQRLYAARRQANLTVAETAQAAGVSEDAIARTE-
MAB_1298c|M.abscessus_ATCC_199 -------------ATLGQRLYTARRRARLTAQETANGAGLKVGFLTAIE-
MAV_3010|M.avium_104 LIGERAIFLREQAVGLSTSAYLLAKVCVYTVFAIVQSAIVTTIAVLGKGA
MUL_3149|M.ulcerans_Agy99 LIGERAIFRREQAVGLSTTAYLLAKICVYTVFAVVQSAIVTIIVLIGKGG
. *. * : . : .:.* : :
Rv3863|M.tuberculosis_H37Rv ----------------AEEELPAEATEAIEALIRQIN-------------
Mb3893|M.bovis_AF2122/97 ----------------AEEELPAEATEAIEALIRQIN-------------
MMAR_5438|M.marinum_M ----------------AEEALHAEAAEAIEALIRQIN-------------
Mflv_0777|M.gilvum_PYR-GCK ----------------AGEPVTASEADAIETLVGQIA-------------
Mvan_0068|M.vanbaalenii_PYR-1 ----------------ADEPLSPADIAAIETLISQIG-------------
TH_2085|M.thermoresistible__bu ----------------ADEPVAATAAGAIETLIAELDQP-----------
MSMEG_0052|M.smegmatis_MC2_155 ----------------AEYPVDAAAVHAIEALIDSLR-------------
MAB_1298c|M.abscessus_ATCC_199 ----------------SEEPVTEDEAAKIKDLIAALGG------------
MAV_3010|M.avium_104 PTQGAVALGKPALELFADVALTCVASAMLGLALSAVAKSNEQIMPLLVVA
MUL_3149|M.ulcerans_Agy99 PTQGAVALGKPGLELFADVAATCVASAMLGLALSAVAKSNEQIMPLLVVA
: : : :
Rv3863|M.tuberculosis_H37Rv --------------------------------------------------
Mb3893|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5438|M.marinum_M --------------------------------------------------
Mflv_0777|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2085|M.thermoresistible__bu --------------------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1298c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3010|M.avium_104 VMSQLVFSGGMIPVTGRVGLDQMAWATPARWGFAASASTADLTKLVPGPL
MUL_3149|M.ulcerans_Agy99 VMSQLVFSGGMIPVTDRLGLDQMSWATPARWGFATSASTVDLIKLVPGPL
Rv3863|M.tuberculosis_H37Rv -----------------------------------------
Mb3893|M.bovis_AF2122/97 -----------------------------------------
MMAR_5438|M.marinum_M -----------------------------------------
Mflv_0777|M.gilvum_PYR-GCK -----------------------------------------
Mvan_0068|M.vanbaalenii_PYR-1 -----------------------------------------
TH_2085|M.thermoresistible__bu -----------------------------------------
MSMEG_0052|M.smegmatis_MC2_155 -----------------------------------------
MAB_1298c|M.abscessus_ATCC_199 -----------------------------------------
MAV_3010|M.avium_104 TPKDSHWRHAPGTWWFDVGMLILISTVYLGFVRWKIRLKGG
MUL_3149|M.ulcerans_Agy99 TPKDSHWHHTASAWWFDMAMLAFISLCYVSFVRWKIRLKGG