For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VSFVVTVPEAVAAAAGDLAAIGSTLREATAAAAGPTTGLAAAAADDVSIAVSQLFGRYGQEFQTVSNQLA AFHTEFVRTLNRGAAAYLNTESANGGQLFGQIEAGQRAVSAAAAAAPGGAYGQLVANTATNLESLYGAWS ANPFPFLRQIIANQQVYWQQIAAALANAVQNFPALVANLPAAIDAAVQQFLAFNAAYYIQQIISSQIGFA QLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGDYNAAVANLGKAMTNLLVTGFDTSDVTIGTMGTTI SVTAKPKLLGPLGDLFTIMTIPAQEAQYFTNLMPPSILRDMSQNFTNVLTTLSNPNIQAVASFDIATTAG TLSTFFGVPLVLTYATLGAPFASLNAIATSAETIEQALLAGNYLGAVGALIDAPAHALDGFLNSATVLDT PILVPTGLPSPLPPTVGITLHLPFDGILVPPHPVTATISFPGAPVPIPGFPTTVTVFGTPFMGMAPLLIN YIPQQLALAIKPAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3812 | PE_PGRS62 | - | 100% (504) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1651c | PE_PGRS30 | 6e-44 | 33.17% (416) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv2162c | PE_PGRS38 | 2e-26 | 48.91% (137) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3842 | PE_PGRS62 | 0.0 | 100.00% (504) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_0292 | - | 2e-06 | 28.87% (97) | hypothetical protein Mflv_0292 |
| M. leprae Br4923 | MLBr_01183 | - | 4e-12 | 36.46% (96) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3494 | - | 2e-81 | 34.78% (575) | PE-PGRS family protein |
| M. avium 104 | MAV_2915 | - | 2e-15 | 45.65% (92) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_6033 | - | 1e-06 | 25.00% (268) | hypothetical protein MSMEG_6033 |
| M. thermoresistible (build 8) | TH_2519 | - | 2e-09 | 29.67% (209) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1640 | - | 2e-78 | 40.82% (392) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3812|M.tuberculosis_H37Rv -MSFVVTVPEAVAAAAG-----DLAAIGSTLREATAAAAGPTTGLAA--A
Mb3842|M.bovis_AF2122/97 -MSFVVTVPEAVAAAAG-----DLAAIGSTLREATAAAAGPTTGLAA--A
MUL_1640|M.ulcerans_Agy99 -MSFVIADPEMVTAAAA-----DLAGIRSTLGAAAEAAAGPTTGVAA--A
MAV_2915|M.avium_104 -MMYVTAQPEAMNAAAD-----RLQQIGTALAAQTGANSAPMTGVVP--A
MMAR_3494|M.marinum_M -MSLVVAEPDALSNAAG-----HLAGIGSKIEDATAAGAGPTTTVAA--A
MLBr_01183|M.leprae_Br4923 MPLFLNAEPQALTAAAN-----TLEGLSAATVASNAAAAQLTTEIAP--P
TH_2519|M.thermoresistible__bu ----MYARLRSFTTAGV-----ALVGAGIITVAPTIAPPVPDITVEAKYS
Mflv_0292|M.gilvum_PYR-GCK -MHSAPAMETGLYAAPSKPRVSKFLAAGVAVVGAGAVAITPVSPIVADDV
MSMEG_6033|M.smegmatis_MC2_155 -MHHPALASSGDAPAVS--RKDKFLLGGVAVVAASAMAVTPVVHDSPVVH
* : .
Rv3812|M.tuberculosis_H37Rv AADDVSIAVSQLFG---------RYGQEFQTVSNQLAAFHTEFVRTLNRG
Mb3842|M.bovis_AF2122/97 AADDVSIAVSQLFG---------RYGQEFQTVSNQLAAFHTEFVRTLNRG
MUL_1640|M.ulcerans_Agy99 AADEVSAAIAHLFG---------AYGQEFQALNGRAAAFHAELVRLLNGG
MAV_2915|M.avium_104 AADPVSLLAAARFA---------QHGQAFQAVSAEAAAVHEMFVTTLQTS
MMAR_3494|M.marinum_M ASDDVSIAISEFFG---------TYGKQFQTFSARAAAFHDEFVSLLRGG
MLBr_01183|M.leprae_Br4923 AADDVSILLAHFFS---------GHGRQYQAHASQGATNHQDLIQSLLTS
TH_2519|M.thermoresistible__bu SASVQPTAFANPLD---------AYGQLFQNTAENLQGLFSVLSANPAPI
Mflv_0292|M.gilvum_PYR-GCK RSQTHAVALTAAANPTYGSDTSAVYGNLFSQSSANFQNLFQAFASDPFPI
MSMEG_6033|M.smegmatis_MC2_155 RAQTIAYDLTATMDATASP--LSVYGSLISTTIDNLSLLGSAVAANPAPL
:. . : :* . . .
Rv3812|M.tuberculosis_H37Rv AAAYLNTESANGGQLFGQIEAGQRAVSAAAAA------------------
Mb3842|M.bovis_AF2122/97 AAAYLNTESANGGQLFGQIEAGQRAVSAAAAA------------------
MUL_1640|M.ulcerans_Agy99 AASYLSAEVVNVEALLGQSLNGGAAAAADPLSGLLGSILGTSSGGSGSVG
MAV_2915|M.avium_104 AGSYAGTEAAN-------------AAAAR---------------------
MMAR_3494|M.marinum_M AAAYLDTEFANARLGQANPANSPAPAAAAPGG------------------
MLBr_01183|M.leprae_Br4923 SSAYAGTETANHDSL-----------------------------------
TH_2519|M.thermoresistible__bu LQQIVANQVENVEAFFPELVSTLQSLAYAFSP------------------
Mflv_0292|M.gilvum_PYR-GCK LSQVAANQWAYGTKFLSGFSGVSESFNSWWTG------------------
MSMEG_6033|M.smegmatis_MC2_155 LRQVVENQLGYAAQFGATFEAIPTSLQNWYNG------------------
:
Rv3812|M.tuberculosis_H37Rv --------------------------------------------------
Mb3842|M.bovis_AF2122/97 --------------------------------------------------
MUL_1640|M.ulcerans_Agy99 GILGGSGGLLDPILFGGTGGLLGPLVGGNGVLTSLVGSGPLGPFFNGVGG
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M -------------------AFLAELSAGNTELGPITGAISVGELLPGAPP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu --------------------------------------------------
Mflv_0292|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6033|M.smegmatis_MC2_155 --------------------------------------------------
Rv3812|M.tuberculosis_H37Rv --------------------------------------------------
Mb3842|M.bovis_AF2122/97 --------------------------------------------------
MUL_1640|M.ulcerans_Agy99 EIGVVTSALIGGDGAVLLSDQIGGITGTLTSLPGLSGLQTLLPGLFPSSG
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M EIGAAISVLGGGS------------------------LLPGLFGFGPFAP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu --------------------------------------------------
Mflv_0292|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6033|M.smegmatis_MC2_155 --------------------------------------------------
Rv3812|M.tuberculosis_H37Rv ------APGGAYGQLVANTATNLESLYGAWSANPFPFLRQIIANQQVYWQ
Mb3842|M.bovis_AF2122/97 ------APGGAYGQLVANTATNLESLYGAWSANPFPFLRQIIANQQVYWQ
MUL_1640|M.ulcerans_Agy99 DTTTTPAPGGAWQQLFENTSSNLNALGTAWSEDPFPLLRQVIANQQGYAY
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M TTGSPAVAEGPWQTLFANTGANLQTIYSDWAAHPFPVAQQVIANQAEYAR
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu ---------ENPQGVFFMIETAVDLLRAGEIQQAFDVLAMGPVIVIGLPL
Mflv_0292|M.gilvum_PYR-GCK ----------------ANGKAMIEAGFEHFSNGEFADGWDRLNRSFVYAL
MSMEG_6033|M.smegmatis_MC2_155 ----------------TNGKVLLDRAQAELEAGNVGEAYRWFNHSMLYAF
Rv3812|M.tuberculosis_H37Rv Q--IAAALANAVQNFPALVANLPAAIDAAVQQFLAFN-AAYYIQQIISSQ
Mb3842|M.bovis_AF2122/97 Q--IAAALANAVQNFPALVANLPAAIDAAVQQFLAFN-AAYYIQQIISSQ
MUL_1640|M.ulcerans_Agy99 T--LGQDLSLAIQNLPTELAHLPENIETGIQGFLAFN-PGLYAQQFVAST
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M T--IGGGLAAAAQDLPATVANLPANIGLAVADAVNFP-AEL--QGYLGKQ
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu L--MGNLVPAAIDLIGKPLQNLTNVITSFATDPGTLLGLVLAPLNPVMAL
Mflv_0292|M.gilvum_PYR-GCK N--IGSPLYSAFWSQAPSQRNPEGNMGIPEQMAINFQ--------QVVSL
MSMEG_6033|M.smegmatis_MC2_155 QGAFGPLIAPGFILSGIPRGGTEYLVGIPEQIAQNVT--------NLVAA
Rv3812|M.tuberculosis_H37Rv IGFAQLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGDYNAAVANLGK
Mb3842|M.bovis_AF2122/97 IGFAQLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGDYNAAVANLGK
MUL_1640|M.ulcerans_Agy99 MNDFHTIGTSLSEAGQDLQIGLAGFPADMQPAYEAFAAGNYNLAVNDATK
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M VGYGQVVVDALQNAGAELPQTLPNFFGDVDKANQAVMAGDYNDAVDYVPR
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu VGGTGLALQNIVEAAGDPAQLVSALIAAPATILDAALNG----YTPDGGL
Mflv_0292|M.gilvum_PYR-GCK VFDRNSIVNEMTKTVLGPFLGLGFEVALLADAVTLAMKEGDGEGLVRALV
MSMEG_6033|M.smegmatis_MC2_155 TFTSSVVVSALFQGAFATVSGPAFELARIAESLVTSVSSGEALNVVNILA
Rv3812|M.tuberculosis_H37Rv AMT----NLLVTGFDTSDVTIGTMGTTISVTAKPKLLGPLGDLFTIMTIP
Mb3842|M.bovis_AF2122/97 AMT----NLLVTGFDTSDVTIGTMGTTISVTAKPKLLGPLGDLFTIMTIP
MUL_1640|M.ulcerans_Agy99 ALL----NVFITGFDTSNLN------------DIRLLGPVADLFPILALP
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M AAV----DLFLSGVNINNLS------------QITVEGPAGELLPLMSLP
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu LLG----GLLGSGVDG------------------NTGGTIALLHGVRVAI
Mflv_0292|M.gilvum_PYR-GCK NAP----GVMLN--------------------------TFLNGYVNPECE
MSMEG_6033|M.smegmatis_MC2_155 NTPGILVNAALNGFDYADPDPETGQGGFSEWPALLTFAEPGEQGGVRVVA
Rv3812|M.tuberculosis_H37Rv AQEAQYFTNLMPP-SILRDMSQNFTNVLTTLSNPNIQAVASFDIATTAGT
Mb3842|M.bovis_AF2122/97 AQEAQYFTNLMPP-SILRDMSQNFTNVLTTLSNPNIQAVASFDIATTAGT
MUL_1640|M.ulcerans_Agy99 GQDVQGFSNLLPAGSIPAQMTHNLANVLNALTDTSISTTISGTLDPPALV
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M AQMQQDLIDLLPPGAILTQMVQNSFNATNTVVN-----------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu AQVLGYTPNPVSTMMSTHTVSTETPVEIDSLDEGDLVENQSAGSQATAET
Mflv_0292|M.gilvum_PYR-GCK GSNCEVFPGLINAGGTLISLFSELPKAIAEALKPDPVPGAP---------
MSMEG_6033|M.smegmatis_MC2_155 GLLQNLLVNLPKTFADAIDNTPEVVPAAVTVQRIAEDVTVAPVAELTESV
Rv3812|M.tuberculosis_H37Rv LSTFFGVPLVLTYATLGAPFASLNAIATSAETIEQALLAGNYLGAVGALI
Mb3842|M.bovis_AF2122/97 LSTFFGVPLVLTYATLGAPFASLNAIATSAETIEQALLAGNYLGAVGALI
MUL_1640|M.ulcerans_Agy99 LDANFGLPLSILFGVAGAPVAGLDGLATAGTTIGTGVASGNPFMVVGGLI
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M ---------SIALAAIGPPIATLDGFATGLTVLGGAVATGNGVGAVGALL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu NDGPAIREAGVQRLAAPTEPTVESGLEADSKSAEDGDTS---VSAAEETT
Mflv_0292|M.gilvum_PYR-GCK ----WTPPAPSLAAVDSTTMLAARTVTLEIESAAPATETEQAETAPVADE
MSMEG_6033|M.smegmatis_MC2_155 TEAPAVAGPAVETAKLVSTVGTVESEAPAAEVEAVKAEVEPAKAESVPAK
Rv3812|M.tuberculosis_H37Rv DAPAHALDGFLNSATVLDTPILVPTGLPSPLP---------PTVGITLHL
Mb3842|M.bovis_AF2122/97 DAPAHALDGFLNSATVLDTPILVPTGLPSPLP---------PTVGITLHL
MUL_1640|M.ulcerans_Agy99 DAPAVVLDGFLNGETIVDMSLPVTFDVPVLGP---------LNIPVVIHL
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M DMPAYVLDGFLNGETVVELRVPVSETVTIPLTPLTPPIVVGANTPVLVRM
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu GAKEASLTAVESRASLVRDSLRAVPGETVADG----------AKPREQSG
Mflv_0292|M.gilvum_PYR-GCK AAPVEDVVAPVEETEEADETAPVTEEAETEAG------------TEEAAT
MSMEG_6033|M.smegmatis_MC2_155 AETAPAEASPAETEQAVVDSTPAASTGADAEG-AVKSKTKVKVTDRIKAK
Rv3812|M.tuberculosis_H37Rv PFDGILVPPHPVTATISFPGAPVPIPGFPTTVTVFGTPFMGMAPLLINYI
Mb3842|M.bovis_AF2122/97 PFDGILVPPHPVTATISFPGAPVPIPGFPTTVTVFGTPFMGMAPLLINYI
MUL_1640|M.ulcerans_Agy99 PFQGLLVPPHPITATVPLEILGVDIP---INLTLGGTQFGGLVPTLVNYT
MAV_2915|M.avium_104 --------------------------------------------------
MMAR_3494|M.marinum_M PFGGVLAQPQPITATIELPGTGSPAP---LDITIPDMQVAGVVPTLLNVI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
TH_2519|M.thermoresistible__bu PVRGVRGQLRTTAPSVQNGVAATSAVG--ERVSTNAKDASGSSTSTATGS
Mflv_0292|M.gilvum_PYR-GCK EEDGDAEAPAADESDSDSKDSDDSGDARKSGKPAQAERSSGSSDSSDSGS
MSMEG_6033|M.smegmatis_MC2_155 ISEAKEARQAKLKAAKEAKKAKAAAKAEAKAAKAAAKDTKSNTGSESKGS
Rv3812|M.tuberculosis_H37Rv PQQLALAIKPAA
Mb3842|M.bovis_AF2122/97 PQQLALAIKPAA
MUL_1640|M.ulcerans_Agy99 SRHLANAITPAA
MAV_2915|M.avium_104 ------------
MMAR_3494|M.marinum_M PQRVAEAIAPE-
MLBr_01183|M.leprae_Br4923 ------------
TH_2519|M.thermoresistible__bu NDRGPGDADE--
Mflv_0292|M.gilvum_PYR-GCK SSSDSGSSGSDD
MSMEG_6033|M.smegmatis_MC2_155 GESKGGSDSSE-