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HSEQSASIEHVDVLIVGAGISGTGAAYYLKTMQPAKTFAIVEARYPAIRSDSDLHTFSYEFKPWQHEKAT ASADAIMVHRGRSLAGGDRTLRHRRTRHHELRMVIIGSGATAVTLVPAMAQTAGAVTMPK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3742c | - | - | 100% (131) | POSSIBLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv3854c | ethA | 1e-15 | 40.57% (106) | monooxygenase ETHA |
| M. tuberculosis H37Rv | Rv3083 | - | 8e-14 | 43.04% (79) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3768c | - | 1e-71 | 100.00% (131) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1123 | - | 3e-17 | 44.90% (98) | FAD dependent oxidoreductase |
| M. leprae Br4923 | MLBr_00065 | - | 8e-14 | 42.17% (83) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_0103 | - | 2e-17 | 43.00% (100) | monooxygenase EthA |
| M. marinum M | MMAR_5279 | - | 5e-28 | 68.48% (92) | monooxygenase-like flavoprotein |
| M. avium 104 | MAV_4576 | - | 9e-12 | 41.03% (78) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_6440 | - | 4e-14 | 39.42% (104) | monooxygenase, flavin-binding family protein |
| M. thermoresistible (build 8) | TH_1149 | - | 5e-16 | 43.43% (99) | MONOOXYGENASE ETHA |
| M. ulcerans Agy99 | MUL_4352 | - | 3e-28 | 68.48% (92) | monooxygenase-like flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_5683 | - | 1e-15 | 42.86% (98) | hypothetical protein Mvan_5683 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6440|M.smegmatis_MC2_155 --------------MTEHFDVVIVGAGISGISTAWHLQDRCPTKSYVILE
TH_1149|M.thermoresistible__bu ------------VVMTEHLDVLIVGAGISGISAAWHLQDRCPSKSYAILE
Mflv_1123|M.gilvum_PYR-GCK --------------MTEEVDVVVVGAGISGISAAWHLQNRCPGKSYVILE
Mvan_5683|M.vanbaalenii_PYR-1 --------------MTEFVDVVIVGAGISGISAAWHLQDRCPGKSYVILE
MLBr_00065|M.leprae_Br4923 ---------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILE
MAB_0103|M.abscessus_ATCC_1997 --------------MSEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLE
MAV_4576|M.avium_104 MTVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILE
Rv3742c|M.tuberculosis_H37Rv -------MHSEQSASIEHVDVLIVGAGISGTGAAYYLKTMQPAKTFAIVE
Mb3768c|M.bovis_AF2122/97 -------MHSEQSASIEHVDVLIVGAGISGTGAAYYLKTMQPAKTFAIVE
MMAR_5279|M.marinum_M -------MNS---SSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVE
MUL_4352|M.ulcerans_Agy99 -------MNS---SSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVE
: .**::******* .:*: : * ::.::*
MSMEG_6440|M.smegmatis_MC2_155 RRANIGGTWDLFKYPGIRSDSDMFTLGFRFKPWTSAKSIADGPSIWNYIN
TH_1149|M.thermoresistible__bu RRDNLGGTWDLFKYPGIRSDSDMFTLGFRFKPWTDPKAIADGPDILAYLK
Mflv_1123|M.gilvum_PYR-GCK GRDDLGGTWDLFRYPGIRSDSDMFTLGFRFKPWTSEKAIADAPSIMAYLR
Mvan_5683|M.vanbaalenii_PYR-1 RRDNLGGTWDLFKYPGIRSDSDMFTLGFRFKPWTSDKAIADGPDIMAYLN
MLBr_00065|M.leprae_Br4923 KRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKPILEYIK
MAB_0103|M.abscessus_ATCC_1997 ARDDMGGTWNLFKYPGIRSDSDMYTLGFRFSPWNDSRTLADGPSILDYVH
MAV_4576|M.avium_104 RRARIGGTWDLFRYPGVRSDSSIFTLSFPFEPWTRKEGVADGVHIREYLT
Rv3742c|M.tuberculosis_H37Rv AR-----------YPAIRSDSDLHTFSYEFKPWQHEKATASADAIMVHRG
Mb3768c|M.bovis_AF2122/97 AR-----------YPAIRSDSDLHTFSYEFKPWQHEKATASADAIMVHRG
MMAR_5279|M.marinum_M ARNDIGGTWDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLR
MUL_4352|M.ulcerans_Agy99 ARNDIGGTWDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLR
* **.:****.:.*:.: * .* . *.. * :
MSMEG_6440|M.smegmatis_MC2_155 EAAQENGIDKHIRTNHRVLGADWSDAENRWTITVEA---DGEQKQITASF
TH_1149|M.thermoresistible__bu ETAEEFGIDEHIRYRHRVVSANWSDPDNKWILQVER---DGEQVEMTCSF
Mflv_1123|M.gilvum_PYR-GCK ETVAEFGIDRHIRYGHRMVAADWSDADNRWTVHVER---GGERVEISARY
Mvan_5683|M.vanbaalenii_PYR-1 ETVAEYGIDKHIRYGQNVKSADWSDADNRWTVRVDR---AGEEVEISARY
MLBr_00065|M.leprae_Br4923 STAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVEN---NGTPRMISCSF
MAB_0103|M.abscessus_ATCC_1997 KTAANAGIDGHVRYRQKVVGAAWNTETQQWTVEVDH---DGKTIEYTCSF
MAV_4576|M.avium_104 ATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDGERKLYRARF
Rv3742c|M.tuberculosis_H37Rv RSLAG------------------GDRTLRHRRT-----------------
Mb3768c|M.bovis_AF2122/97 RSLAG------------------GDRTLRHRRT-----------------
MMAR_5279|M.marinum_M ETVAENSLARAIRFGHKVIEAAWSTRDARWRVTIER-LYSGERVTMSCEW
MUL_4352|M.ulcerans_Agy99 ETVAENSLARAIRFGHKVIESAWSTRDARWRVTIER-LCSGERVTMSCEW
: .
MSMEG_6440|M.smegmatis_MC2_155 LSVCSGYYNYDQGYSPEFPGADDFAGQIIHPQHWPEDLDYAGKKIVVIGS
TH_1149|M.thermoresistible__bu LFACSGYYNYDEGYSPEFPGADDFEGTIVHPQHWPEDLDYAGKRIVVIGS
Mflv_1123|M.gilvum_PYR-GCK LMACSGYYDYDRGYSPEFAGAQDFEGPIIHPQHWPEDLDYTGKRVVVIGS
Mvan_5683|M.vanbaalenii_PYR-1 LMACSGYYNYDEGYSPDFPGSEDFEGTLIHPQHWPEDLDYAGKRIVVIGS
MLBr_00065|M.leprae_Br4923 LFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGS
MAB_0103|M.abscessus_ATCC_1997 LFCCSGYYDYDQGYSPEFPGVADFKGTVVHPQHWPEDLDYKGKKVVVIGS
MAV_4576|M.avium_104 LFFGSGYYNYDEGYTPDFPGIEEFTGTVVHPQHWPEDLDYTGKKVVVIGS
Rv3742c|M.tuberculosis_H37Rv --------RHHE------------------------------LRMVIIGS
Mb3768c|M.bovis_AF2122/97 --------RHHE------------------------------LRMVIIGS
MMAR_5279|M.marinum_M FFCASGYYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLIIGS
MUL_4352|M.ulcerans_Agy99 FFCASGYYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLIIGS
:.. .:::***
MSMEG_6440|M.smegmatis_MC2_155 GATAVTLIPSLVNGGAAHVTMLQRSPTYIGSLPLVDPVAEKTNKYLPKNL
TH_1149|M.thermoresistible__bu GATAVTLIPALAETGAGHVTMLQRSPTYIGSLPLVDPIAVKVNKYLPPKM
Mflv_1123|M.gilvum_PYR-GCK GATAVTLVPALADSGAGHVTMLQRSPTYIGALPDVDPFTVRTNKTLPTGA
Mvan_5683|M.vanbaalenii_PYR-1 GATAVTLIPALANSGAGHVTMLQRSPTFIAALPDVDPFTVATNKRLPAKV
MLBr_00065|M.leprae_Br4923 GATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKY
MAB_0103|M.abscessus_ATCC_1997 GATAVTLVPAMAP-DTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKV
MAV_4576|M.avium_104 GATAVTLLPSLSD-RAAKVTMLQRSPTYLISASKYGKVAAVARKVLPRKP
Rv3742c|M.tuberculosis_H37Rv GATAVTLVPAMAQ-TAGAVTMPK---------------------------
Mb3768c|M.bovis_AF2122/97 GATAVTLVPAMAQ-TAGAVTMPK---------------------------
MMAR_5279|M.marinum_M GATAVTLVPAMAE-TAGHVTMLQRSPTYIIPVPSKDRIANTLPKLVGRKR
MUL_4352|M.ulcerans_Agy99 GATAVTLVPAMAE-TAGHVTMLQRSPTYIIPVPSKDRIANTLPKLVGRKR
*******:*:: : :** :
MSMEG_6440|M.smegmatis_MC2_155 AHFVNRWKAIAFSTAQYQLARKFPNYMRKTLMTMAQRRLPEGFDVQKHFG
TH_1149|M.thermoresistible__bu ASVVNRWKAIIFSTFQYQLSRKFPNYMRRTLMRMAERRLPPGYDVEKHFG
Mflv_1123|M.gilvum_PYR-GCK AYVVNRWKSILFQSVQYQLSRRFPRFMRRTLMTMAQRRLPEGYDIARHFG
Mvan_5683|M.vanbaalenii_PYR-1 AYVLNRWKSILQQSVQYQVARKFPDFFRKQLLTMAKHRLPEGYDVNKHFN
MLBr_00065|M.leprae_Br4923 AYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFG
MAB_0103|M.abscessus_ATCC_1997 AYPIARWINIGQLIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFG
MAV_4576|M.avium_104 AHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVDIHFK
Rv3742c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3768c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M AYALTRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGYPVDEHFR
MUL_4352|M.ulcerans_Agy99 AYALTRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGYPVDEHFR
MSMEG_6440|M.smegmatis_MC2_155 PRYNPWDERLCLAPNGDLFKTIRAGKADVVTDTIAKFTETGIKLTSGEEL
TH_1149|M.thermoresistible__bu PRYNPWDERLCLAPNGDLFRAIRHGKADVVTDTIDTFTKTGIRLTSGTEL
Mflv_1123|M.gilvum_PYR-GCK PSYNPWDQRLCLAPNGDLFETIRTGRADVVTDTIERFDRTGITLSSGQHL
Mvan_5683|M.vanbaalenii_PYR-1 PRYNPWDERVCLAPNGDLFKTIRAGKADVVTDTIERFTKTGIQLASGRHL
MLBr_00065|M.leprae_Br4923 PHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNEL
MAB_0103|M.abscessus_ATCC_1997 PKYNPWDERLCVVPNGDLYKAIRKGKADIVTDHIETFDETGIKLKSGKHL
MAV_4576|M.avium_104 PRYNPWDQRMCLIPDADLYNAITAGRADVVTDHIDHFDATGIALRSGAHL
Rv3742c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3768c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M PDYNPWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQSGREL
MUL_4352|M.ulcerans_Agy99 PDYNPWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQSGREL
MSMEG_6440|M.smegmatis_MC2_155 TADIIITATGLNMQLFGGASLTRNGQEVDLTETMTYKGLMLSGVPNMAIT
TH_1149|M.thermoresistible__bu EADIIITATGLNLQLFGGAEIKRNGQPVELTETMAYKGMMLSGMPNMAFT
Mflv_1123|M.gilvum_PYR-GCK DADIIVTATGLNLRLFGGAVISRNGEVIELSETMAYKGMLLTGMPNLAFT
Mvan_5683|M.vanbaalenii_PYR-1 DADIIVTATGLNLQLFGGATISRNGEAIELNDTMAYKGMLLTDMPNLAFT
MLBr_00065|M.leprae_Br4923 RADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYT
MAB_0103|M.abscessus_ATCC_1997 DADIIITATGLNLKFFSGVIPTVDGVPVDLPAQTVYKGAMLTGIPNMAFT
MAV_4576|M.avium_104 DADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPNLFWC
Rv3742c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3768c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M EADIIVTATGLNLLAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPNFAYV
MUL_4352|M.ulcerans_Agy99 EADIIVTATGLNLLAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPNFAYV
MSMEG_6440|M.smegmatis_MC2_155 FGYTNASWTLKADLVSEFICRVLNYMDDNGFDRVEPQHPGDAVDALPFMD
TH_1149|M.thermoresistible__bu IGYTNASWTLKADLVSEFVCRVLNHMDEHGYDVVEPQHPGDSVEERPLLD
Mflv_1123|M.gilvum_PYR-GCK IGYTNASWTLKADLVSEFFCRIINYMDEHSYTRMEPRHPGGGVDERPLLD
Mvan_5683|M.vanbaalenii_PYR-1 IGYTNASWTLKADLVSEFFCRIINYMDANSYDRVEPRHPGSSVDERPLMD
MLBr_00065|M.leprae_Br4923 VGYTNASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMD
MAB_0103|M.abscessus_ATCC_1997 IGYTNASWTLKADLVSEYVSRLLNYMDENGYVTAVPELADETLEKQPFMD
MAV_4576|M.avium_104 VGYTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNEPMTEKPSWD
Rv3742c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3768c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M FGYTNSSWTLKVGLVCEHFCRLLAHMDANGHNICRPHAP-ASMPTRPLLE
MUL_4352|M.ulcerans_Agy99 FGYTNSSWTLKVGLVCEHFCRLLAHMDANGHNICRPHAP-ASMPTRPLLE
MSMEG_6440|M.smegmatis_MC2_155 FNPGYFRRAMDSLPKSGS-RAPWRLKQNYFFDLRMIRYDKVDEESLHFTK
TH_1149|M.thermoresistible__bu FTPGYVLRALDRLPPPXXXRMWWTRCRRSRFAAGPPAWRSTTRRRSSRPR
Mflv_1123|M.gilvum_PYR-GCK FTPGYVLRALDHLPKAGS-RAPWRLKQNYLLDLQLIRRGRVDDEALEFGQ
Mvan_5683|M.vanbaalenii_PYR-1 FTPGYVLRALDYLPKAGS-RAPWRLKQNYLMDLQLIRRGKVDDEALAFSR
MLBr_00065|M.leprae_Br4923 FTPGYVLRSLDALPKQGS-RTPWRLNQNYLRDIRLIRRGKVADEGLLFAK
MAB_0103|M.abscessus_ATCC_1997 FTPGYVLRALDELPKQGN-KHPWRLKQNYAYDIGMMRRSRVT-EGMRFGR
MAV_4576|M.avium_104 INAGYVLRSVHALPKSGT-KRPWNVRQNYLADAIDYRFDRIE-EAMVFGR
Rv3742c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3768c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M ITAGYVKRAAAAFPHQGT-EGPWRTCMDYRADRATLREGPVDDDHLQFSA
MUL_4352|M.ulcerans_Agy99 ITAGYVKRAAAAFPHQGT-EGPWRTCMDYRADRATLREGPVDDDHLQFSA
MSMEG_6440|M.smegmatis_MC2_155 HRAAVSASSS------
TH_1149|M.thermoresistible__bu PGRWGSTGCG------
Mflv_1123|M.gilvum_PYR-GCK SAVTTTIPSSSL----
Mvan_5683|M.vanbaalenii_PYR-1 HPAQVTASA-------
MLBr_00065|M.leprae_Br4923 KTTPVTV---------
MAB_0103|M.abscessus_ATCC_1997 KKTAAAPASESVAVNS
MAV_4576|M.avium_104 AADRAALAG-------
Rv3742c|M.tuberculosis_H37Rv ----------------
Mb3768c|M.bovis_AF2122/97 ----------------
MMAR_5279|M.marinum_M SAAADTPPLALTG---
MUL_4352|M.ulcerans_Agy99 SAAADTPPLALTG---