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TEHFDVVIVGAGISGISTAWHLQDRCPTKSYVILERRANIGGTWDLFKYPGIRSDSDMFTLGFRFKPWTS AKSIADGPSIWNYINEAAQENGIDKHIRTNHRVLGADWSDAENRWTITVEADGEQKQITASFLSVCSGYY NYDQGYSPEFPGADDFAGQIIHPQHWPEDLDYAGKKIVVIGSGATAVTLIPSLVNGGAAHVTMLQRSPTY IGSLPLVDPVAEKTNKYLPKNLAHFVNRWKAIAFSTAQYQLARKFPNYMRKTLMTMAQRRLPEGFDVQKH FGPRYNPWDERLCLAPNGDLFKTIRAGKADVVTDTIAKFTETGIKLTSGEELTADIIITATGLNMQLFGG ASLTRNGQEVDLTETMTYKGLMLSGVPNMAITFGYTNASWTLKADLVSEFICRVLNYMDDNGFDRVEPQH PGDAVDALPFMDFNPGYFRRAMDSLPKSGSRAPWRLKQNYFFDLRMIRYDKVDEESLHFTKHRAAVSASS S*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6440 | - | - | 100% (492) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_2038 | - | e-135 | 46.61% (487) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_2884 | - | 2e-33 | 26.67% (405) | cyclohexanone monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3884c | ethA | 0.0 | 65.71% (487) | monooxygenase ETHA |
| M. gilvum PYR-GCK | Mflv_0962 | - | 0.0 | 87.58% (491) | monooxygenase, flavin-binding family protein |
| M. tuberculosis H37Rv | Rv3854c | ethA | 0.0 | 65.71% (487) | monooxygenase ETHA |
| M. leprae Br4923 | MLBr_00065 | - | 0.0 | 64.68% (487) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_0103 | - | 1e-178 | 58.94% (492) | monooxygenase EthA |
| M. marinum M | MMAR_5404 | ethA | 0.0 | 66.12% (487) | monooxygenase EthA |
| M. avium 104 | MAV_0175 | - | 0.0 | 77.97% (472) | monooxygenase, flavin-binding family protein |
| M. thermoresistible (build 8) | TH_1149 | - | 0.0 | 76.26% (455) | MONOOXYGENASE ETHA |
| M. ulcerans Agy99 | MUL_5026 | ethA | 0.0 | 65.30% (487) | monooxygenase EthA |
| M. vanbaalenii PYR-1 | Mvan_5683 | - | 0.0 | 71.08% (491) | hypothetical protein Mvan_5683 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3884c|M.bovis_AF2122/97 -----MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTW
Rv3854c|M.tuberculosis_H37Rv -----MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTW
MMAR_5404|M.marinum_M -----MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRAAMGGTW
MUL_5026|M.ulcerans_Agy99 -----MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRAAMGGTW
MLBr_00065|M.leprae_Br4923 MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKRAGMGGTW
MSMEG_6440|M.smegmatis_MC2_155 -----MTEHFDVVIVGAGISGISTAWHLQDRCPTKSYVILERRANIGGTW
Mflv_0962|M.gilvum_PYR-GCK -----MSDHFDVVIVGAGISGISTAWHLQQRCPDKSYVILERRENIGGTW
MAV_0175|M.avium_104 ---------------------MSAAWHLQNRCPTKSYAILERRADLGGTW
TH_1149|M.thermoresistible__bu ---VVMTEHLDVLIVGAGISGISAAWHLQDRCPSKSYAILERRDNLGGTW
Mvan_5683|M.vanbaalenii_PYR-1 -----MTEFVDVVIVGAGISGISAAWHLQDRCPGKSYVILERRDNLGGTW
MAB_0103|M.abscessus_ATCC_1997 -----MSEHFDVLIVGAGISGISAAWHIQDRCPTKTYAVLEARDDMGGTW
:*:***:*:*** *:*.:** * :****
Mb3884c|M.bovis_AF2122/97 DLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGID
Rv3854c|M.tuberculosis_H37Rv DLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGID
MMAR_5404|M.marinum_M DLFRYPGIRSDSDMHTLGFRFRPWTERQAIADGKPILEYVKGTAAMYGID
MUL_5026|M.ulcerans_Agy99 ELFRYPGIRSDSDMHTLGFRFRPWTERQAIADGKPILEYVKGTAAMYGID
MLBr_00065|M.leprae_Br4923 DLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKPILEYIKSTAVMHGID
MSMEG_6440|M.smegmatis_MC2_155 DLFKYPGIRSDSDMFTLGFRFKPWTSAKSIADGPSIWNYINEAAQENGID
Mflv_0962|M.gilvum_PYR-GCK DLFKYPGIRSDSDMFTLGFRFKPWPSARSIADGPSIWNYINEAAQENGID
MAV_0175|M.avium_104 DLFKYPGIRSDSDMFTLGFRFKPWRSAKSIADGASIKAYIKEAAVENRIE
TH_1149|M.thermoresistible__bu DLFKYPGIRSDSDMFTLGFRFKPWTDPKAIADGPDILAYLKETAEEFGID
Mvan_5683|M.vanbaalenii_PYR-1 DLFKYPGIRSDSDMFTLGFRFKPWTSDKAIADGPDIMAYLNETVAEYGID
MAB_0103|M.abscessus_ATCC_1997 NLFKYPGIRSDSDMYTLGFRFSPWNDSRTLADGPSILDYVHKTAANAGID
:**:**********.****** ** :::*** * *:: :. *:
Mb3884c|M.bovis_AF2122/97 RHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDE
Rv3854c|M.tuberculosis_H37Rv RHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDE
MMAR_5404|M.marinum_M KHIRLNQKVISADWSNAQNRWTLQIESNGATSAVTCSFLFLCSGYYNYDQ
MUL_5026|M.ulcerans_Agy99 KHIRLNQKVISADWSNAQNRWTLQIESNGAMSAVTCSFLFLCSGYYNYDQ
MLBr_00065|M.leprae_Br4923 KYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLCSGYYNYEQ
MSMEG_6440|M.smegmatis_MC2_155 KHIRTNHRVLGADWSDAENRWTITVEADGEQKQITASFLSVCSGYYNYDQ
Mflv_0962|M.gilvum_PYR-GCK KHIRVKHQVLAANWSDAENRWELTVDHDGEQKQITCSFLSVCSGYYNYDQ
MAV_0175|M.avium_104 PHIRYRHRVVAADWSDADNRWTVTVEHDGQRSEITCSFLFACTGYYNYDE
TH_1149|M.thermoresistible__bu EHIRYRHRVVSANWSDPDNKWILQVERDGEQVEMTCSFLFACSGYYNYDE
Mvan_5683|M.vanbaalenii_PYR-1 KHIRYGQNVKSADWSDADNRWTVRVDRAGEEVEISARYLMACSGYYNYDE
MAB_0103|M.abscessus_ATCC_1997 GHVRYRQKVVGAAWNTETQQWTVEVDHDGKTIEYTCSFLFCCSGYYDYDQ
::* :.* .* *. ::* : :: * :. :* *:***:*::
Mb3884c|M.bovis_AF2122/97 GYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALA
Rv3854c|M.tuberculosis_H37Rv GYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALA
MMAR_5404|M.marinum_M GYTPNFAGAQDFAGSIIHPQHWPEDLDYDGKNVVVIGSGATAVTLVPALA
MUL_5026|M.ulcerans_Agy99 GYTPNFAGAQDFAGSIIHPQHWPEDLDYDGKNVVVIGSGASAVTLVPALA
MLBr_00065|M.leprae_Br4923 GYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATAVTLVPALA
MSMEG_6440|M.smegmatis_MC2_155 GYSPEFPGADDFAGQIIHPQHWPEDLDYAGKKIVVIGSGATAVTLIPSLV
Mflv_0962|M.gilvum_PYR-GCK GYSPEFPGADDFAGQIIHPQHWPEDLDYTGKRIVVIGSGATAVTLIPSLV
MAV_0175|M.avium_104 GYSPTFPGAEDFGGTIVHPQHWPEDLDYAGKRIVVIGSGATAITLIPALV
TH_1149|M.thermoresistible__bu GYSPEFPGADDFEGTIVHPQHWPEDLDYAGKRIVVIGSGATAVTLIPALA
Mvan_5683|M.vanbaalenii_PYR-1 GYSPDFPGSEDFEGTLIHPQHWPEDLDYAGKRIVVIGSGATAVTLIPALA
MAB_0103|M.abscessus_ATCC_1997 GYSPEFPGVADFKGTVVHPQHWPEDLDYKGKKVVVIGSGATAVTLVPAMA
**:* * * ** * ::*********** .*.:*******:*:**:*::.
Mb3884c|M.bovis_AF2122/97 DSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLR
Rv3854c|M.tuberculosis_H37Rv DSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLR
MMAR_5404|M.marinum_M NSGAKHVTMLQRSPTYIVSQPERDSIAERLNRWLPENMAYAMVRWKNVLR
MUL_5026|M.ulcerans_Agy99 NSGAKHVTMLQRSPTYIVSQPERDSIAERLNRWLPENMAYAMVRWKNVLR
MLBr_00065|M.leprae_Br4923 NSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPDKYAYTAVRWKNILR
MSMEG_6440|M.smegmatis_MC2_155 NGGAAHVTMLQRSPTYIGSLPLVDPVAEKTNKYLPKNLAHFVNRWKAIAF
Mflv_0962|M.gilvum_PYR-GCK AGGAGHVTMLQRSPTYIGSLPLVDPIAEKANKYLPGSLAHFVNRWKAISF
MAV_0175|M.avium_104 NSGAGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMANRWKAIAF
TH_1149|M.thermoresistible__bu ETGAGHVTMLQRSPTYIGSLPLVDPIAVKVNKYLPPKMASVVNRWKAIIF
Mvan_5683|M.vanbaalenii_PYR-1 NSGAGHVTMLQRSPTFIAALPDVDPFTVATNKRLPAKVAYVLNRWKSILQ
MAB_0103|M.abscessus_ATCC_1997 P-DTGHITMLQRSPTYIMSLPNENPIINGLRKILPPKVAYPIARWINIGQ
.: *:********:* : * : . .: ** * ** :
Mb3884c|M.bovis_AF2122/97 QAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCL
Rv3854c|M.tuberculosis_H37Rv QAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCL
MMAR_5404|M.marinum_M QAAVYGACRKWPRRMRKNFMGLAQRQLPEGYDVRKHFGPHYNPWDQRLCL
MUL_5026|M.ulcerans_Agy99 QAAVYGACRKWPRRMRKNFMGLAQRQLPEGYDVRKHFGPHYNPWDQRLCL
MLBr_00065|M.leprae_Br4923 QSALYGACQKWPQRMRNILLGHVARRLPKGYDVQKHFGPHYNPWEQRLCL
MSMEG_6440|M.smegmatis_MC2_155 STAQYQLARKFPNYMRKTLMTMAQRRLPEGFDVQKHFGPRYNPWDERLCL
Mflv_0962|M.gilvum_PYR-GCK STLQYQLSQRFPKYMRKTLMTMAQRRLPEGYDVEKHFGPRYNPWDERLCL
MAV_0175|M.avium_104 STFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYNVWDERLCL
TH_1149|M.thermoresistible__bu STFQYQLSRKFPNYMRRTLMRMAERRLPPGYDVEKHFGPRYNPWDERLCL
Mvan_5683|M.vanbaalenii_PYR-1 QSVQYQVARKFPDFFRKQLLTMAKHRLPEGYDVNKHFNPRYNPWDERVCL
MAB_0103|M.abscessus_ATCC_1997 LIFSYQASRKFPRAARRIIMQQAKLQLPKGFDYKTHFGPKYNPWDERLCV
* .:: * *. :: :** *:* ..**.*:** *::*:*:
Mb3884c|M.bovis_AF2122/97 VPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLN
Rv3854c|M.tuberculosis_H37Rv VPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLN
MMAR_5404|M.marinum_M VPNGDLFRAIRHGQVDVVTDTIDRFTPTGIRLNSGQQLPADIIVTATGLN
MUL_5026|M.ulcerans_Agy99 VPNGDLFRAIRHGQVDVVTDTIDRFTPTGIRLNSGQQLPADIIVTATGLN
MLBr_00065|M.leprae_Br4923 VPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKSGNELRADIIVTATGLN
MSMEG_6440|M.smegmatis_MC2_155 APNGDLFKTIRAGKADVVTDTIAKFTETGIKLTSGEELTADIIITATGLN
Mflv_0962|M.gilvum_PYR-GCK APNGDLFKTIRAGKADVVTDTIDRFTETGIRLNSGEELAADIIITATGLN
MAV_0175|M.avium_104 APDGDFFRTIRHGKADVVTDTIDRFTTTGIRLNSGEELPADIIVTATGLN
TH_1149|M.thermoresistible__bu APNGDLFRAIRHGKADVVTDTIDTFTKTGIRLTSGTELEADIIITATGLN
Mvan_5683|M.vanbaalenii_PYR-1 APNGDLFKTIRAGKADVVTDTIERFTKTGIQLASGRHLDADIIVTATGLN
MAB_0103|M.abscessus_ATCC_1997 VPNGDLYKAIRKGKADIVTDHIETFDETGIKLKSGKHLDADIIITATGLN
.*:**::::** * .::*** * * ***:* ** .* ****:******
Mb3884c|M.bovis_AF2122/97 LQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKA
Rv3854c|M.tuberculosis_H37Rv LQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKA
MMAR_5404|M.marinum_M LQLFGGAAVTVDGESVDLTKAMAYKGMMLSGLPNMAYTVGYTNASWTLKA
MUL_5026|M.ulcerans_Agy99 LQLFGGAAVTVDGESVDLTKAMAYKGMMLSGLPNMAYTVGYTNASWTLKA
MLBr_00065|M.leprae_Br4923 LQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKA
MSMEG_6440|M.smegmatis_MC2_155 MQLFGGASLTRNGQEVDLTETMTYKGLMLSGVPNMAITFGYTNASWTLKA
Mflv_0962|M.gilvum_PYR-GCK MQLFGGATATRNGEPIDLTKTMTYKGLMLSGVPNMAITFGYTNASWTLKA
MAV_0175|M.avium_104 MQLLGGVTPTRNGDPVDLTSLMTYKGLMFSGMPNFAITFGYTNASWTLKA
TH_1149|M.thermoresistible__bu LQLFGGAEIKRNGQPVELTETMAYKGMMLSGMPNMAFTIGYTNASWTLKA
Mvan_5683|M.vanbaalenii_PYR-1 LQLFGGATISRNGEAIELNDTMAYKGMLLTDMPNLAFTIGYTNASWTLKA
MAB_0103|M.abscessus_ATCC_1997 LKFFSGVIPTVDGVPVDLPAQTVYKGAMLTGIPNMAFTIGYTNASWTLKA
::::.*. . :* ::: *** :::.:**: *.***********
Mb3884c|M.bovis_AF2122/97 DLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDE
Rv3854c|M.tuberculosis_H37Rv DLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDE
MMAR_5404|M.marinum_M DLVSEFVCRLLNYMDANDYDSVVVERPGSDVQECPFMEFTPGYVLRVIDE
MUL_5026|M.ulcerans_Agy99 DLVSEFVCRLLNYMDANDYESVVVERPGSDVQECPFMEFTPGYVLRVIDE
MLBr_00065|M.leprae_Br4923 DLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDA
MSMEG_6440|M.smegmatis_MC2_155 DLVSEFICRVLNYMDDNGFDRVEPQHPGDAVDALPFMDFNPGYFRRAMDS
Mflv_0962|M.gilvum_PYR-GCK DLVSEFICRLLNYMDDNGFDRVEAQHPGDSVEEKPFMDFSPGYFRRAMDT
MAV_0175|M.avium_104 DLVSEFVCRLLNYMDAKGFDFVEPQHPGEDVDALPFMDFTPGYFRRSMHL
TH_1149|M.thermoresistible__bu DLVSEFVCRVLNHMDEHGYDVVEPQHPGDSVEERPLLDFTPGYVLRALDR
Mvan_5683|M.vanbaalenii_PYR-1 DLVSEFFCRIINYMDANSYDRVEPRHPGSSVDERPLMDFTPGYVLRALDY
MAB_0103|M.abscessus_ATCC_1997 DLVSEYVSRLLNYMDENGYVTAVPELADETLEKQPFMDFTPGYVLRALDE
*****:..*::*:*: :.: . . ... :: *:::*.***. * :.
Mb3884c|M.bovis_AF2122/97 LPKQGSRTPWR--LNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV----
Rv3854c|M.tuberculosis_H37Rv LPKQGSRTPWR--LNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV----
MMAR_5404|M.marinum_M LPKQGSRKPWR--LNQNYLRDIHLIRRGKIDDEGLRFAKKPVAVPV----
MUL_5026|M.ulcerans_Agy99 LPKQGSRKPWR--LNQDYLRDIHLIRRGKIDDEGLRFAKKPVAVPV----
MLBr_00065|M.leprae_Br4923 LPKQGSRTPWR--LNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV----
MSMEG_6440|M.smegmatis_MC2_155 LPKSGSRAPWR--LKQNYFFDLRMIRYDKVDEESLHFTKHRAAVSASSS-
Mflv_0962|M.gilvum_PYR-GCK LPKSGSEAPWR--LKQNYFIDLRTIRYGKVDEESLRFTKHGAPVALSS--
MAV_0175|M.avium_104 LPKSGSRAPWR--LKQNYFFDMRTIRRGRVDDEGLKFAKKRAPVAV----
TH_1149|M.thermoresistible__bu LPPPXXXRMWWTRCRRSRFAAGPPAWRSTTRRRSSRPRPGRWGSTGCG--
Mvan_5683|M.vanbaalenii_PYR-1 LPKAGSRAPWR--LKQNYLMDLQLIRRGKVDDEALAFSRHPAQVTASA--
MAB_0103|M.abscessus_ATCC_1997 LPKQGNKHPWR--LKQNYAYDIGMMRRSRVT-EGMRFGRKKTAAAPASES
** * .:. . ..
Mb3884c|M.bovis_AF2122/97 -----
Rv3854c|M.tuberculosis_H37Rv -----
MMAR_5404|M.marinum_M -----
MUL_5026|M.ulcerans_Agy99 -----
MLBr_00065|M.leprae_Br4923 -----
MSMEG_6440|M.smegmatis_MC2_155 -----
Mflv_0962|M.gilvum_PYR-GCK -----
MAV_0175|M.avium_104 -----
TH_1149|M.thermoresistible__bu -----
Mvan_5683|M.vanbaalenii_PYR-1 -----
MAB_0103|M.abscessus_ATCC_1997 VAVNS