For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
IGRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPADEHFKPVYNPWDQRLCAVPD ADMFKAIRDGRASVVTEAIDTFTENGIRLQSGRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVA FKGFLLSDVSNFAGPHGRTRAHHLLSAAARSHADPAAAGRRSPLADLKVLREGPVDDDHLRFTTSASASR LTVKRITRSTPWN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3741c | - | - | 100% (224) | POSSIBLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv3854c | ethA | 3e-42 | 38.46% (247) | monooxygenase ETHA |
| M. tuberculosis H37Rv | Rv3083 | - | 2e-34 | 45.34% (161) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3767c | - | 1e-127 | 100.00% (224) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0962 | - | 1e-38 | 47.53% (162) | monooxygenase, flavin-binding family protein |
| M. leprae Br4923 | MLBr_00065 | - | 3e-40 | 48.15% (162) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2654 | - | 3e-46 | 51.85% (162) | putative monooxygenase |
| M. marinum M | MMAR_5279 | - | 2e-73 | 57.53% (259) | monooxygenase-like flavoprotein |
| M. avium 104 | MAV_4576 | - | 2e-33 | 42.53% (174) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_6440 | - | 3e-36 | 44.85% (165) | monooxygenase, flavin-binding family protein |
| M. thermoresistible (build 8) | TH_1149 | - | 1e-37 | 46.91% (162) | MONOOXYGENASE ETHA |
| M. ulcerans Agy99 | MUL_4352 | - | 1e-73 | 57.53% (259) | monooxygenase-like flavoprotein |
| M. vanbaalenii PYR-1 | Mvan_5683 | - | 1e-36 | 43.83% (162) | hypothetical protein Mvan_5683 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0962|M.gilvum_PYR-GCK --------------MSDHFDVVIVGAGISGISTAWHLQQRCPDKSYVILE
MSMEG_6440|M.smegmatis_MC2_155 --------------MTEHFDVVIVGAGISGISTAWHLQDRCPTKSYVILE
TH_1149|M.thermoresistible__bu ------------VVMTEHLDVLIVGAGISGISAAWHLQDRCPSKSYAILE
Mvan_5683|M.vanbaalenii_PYR-1 --------------MTEFVDVVIVGAGISGISAAWHLQDRCPGKSYVILE
MLBr_00065|M.leprae_Br4923 ---------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILE
MAV_4576|M.avium_104 MTVTPQEAADHGAAEADYFDVLIVGAGISGIDAAYRITERNPQLSYAILE
MAB_2654|M.abscessus_ATCC_1997 --------MTTSAPRPDYYDVVIIGAGISGIGAAAYLTREFPKKKVVLLE
Rv3741c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3767c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M ----------MNSSSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVE
MUL_4352|M.ulcerans_Agy99 ----------MNSSSIEHVDVLIVGAGISGIGAAYYLQEHQPAKTFAIVE
Mflv_0962|M.gilvum_PYR-GCK RRENIGGTWDLFKYPGIRSDSDMFTLGFRFKPWPSARSIADGPSIWNYIN
MSMEG_6440|M.smegmatis_MC2_155 RRANIGGTWDLFKYPGIRSDSDMFTLGFRFKPWTSAKSIADGPSIWNYIN
TH_1149|M.thermoresistible__bu RRDNLGGTWDLFKYPGIRSDSDMFTLGFRFKPWTDPKAIADGPDILAYLK
Mvan_5683|M.vanbaalenii_PYR-1 RRDNLGGTWDLFKYPGIRSDSDMFTLGFRFKPWTSDKAIADGPDIMAYLN
MLBr_00065|M.leprae_Br4923 KRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIADGKPILEYIK
MAV_4576|M.avium_104 RRARIGGTWDLFRYPGVRSDSSIFTLSFPFEPWTRKEGVADGVHIREYLT
MAB_2654|M.abscessus_ATCC_1997 GRGALGGTWDLFRYPGIRSDSDLHTFAYEFKSWRHKNAIADAPLILDYLK
Rv3741c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3767c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M ARNDIGGTWDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLR
MUL_4352|M.ulcerans_Agy99 ARNDIGGTWDLFRYPGIRSDSDLHTFSYEFKAWENEKAIASAGAIMSYLR
Mflv_0962|M.gilvum_PYR-GCK EAAQENGIDKHIRVKHQVLAANWSDAENRWELTVDH---DGEQK--QITC
MSMEG_6440|M.smegmatis_MC2_155 EAAQENGIDKHIRTNHRVLGADWSDAENRWTITVEA---DGEQK--QITA
TH_1149|M.thermoresistible__bu ETAEEFGIDEHIRYRHRVVSANWSDPDNKWILQVER---DGEQV--EMTC
Mvan_5683|M.vanbaalenii_PYR-1 ETVAEYGIDKHIRYGQNVKSADWSDADNRWTVRVDR---AGEEV--EISA
MLBr_00065|M.leprae_Br4923 STAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVEN---NGTPR--MISC
MAV_4576|M.avium_104 ATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDGERK--LYRA
MAB_2654|M.abscessus_ATCC_1997 ETVDEYGLADIIKYRHNVIAAAWSSDDAEWVLTVDVTDPDGSVRSEVIKA
Rv3741c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3767c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M ETVAENSLARAIRFGHKVIEAAWSTRDARWRVTIERLYSGERVT---MSC
MUL_4352|M.ulcerans_Agy99 ETVAENSLARAIRFGHKVIESAWSTRDARWRVTIERLCSGERVT---MSC
Mflv_0962|M.gilvum_PYR-GCK SFLSVCSGYYNYDQGYSPEFPGADDFAGQIIHPQHWPEDLDYTGKRIVVI
MSMEG_6440|M.smegmatis_MC2_155 SFLSVCSGYYNYDQGYSPEFPGADDFAGQIIHPQHWPEDLDYAGKKIVVI
TH_1149|M.thermoresistible__bu SFLFACSGYYNYDEGYSPEFPGADDFEGTIVHPQHWPEDLDYAGKRIVVI
Mvan_5683|M.vanbaalenii_PYR-1 RYLMACSGYYNYDEGYSPDFPGSEDFEGTLIHPQHWPEDLDYAGKRIVVI
MLBr_00065|M.leprae_Br4923 SFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVI
MAV_4576|M.avium_104 RFLFFGSGYYNYDEGYTPDFPGIEEFTGTVVHPQHWPEDLDYTGKKVVVI
MAB_2654|M.abscessus_ATCC_1997 GWVYAGTGYYRYDKAYTPEFEGREEFEGDIIHPQFWPEGYDHSGKNIVVI
Rv3741c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3767c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5279|M.marinum_M EWFFCASGYYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLII
MUL_4352|M.ulcerans_Agy99 EWFFCASGYYRYDEGYTPEFPGRERFAGQVVHPQQWPENLDYRGKRVLII
Mflv_0962|M.gilvum_PYR-GCK GSGATAVTLIPSLVAGG--AGHVTMLQRSPTYIGSLPLVDPIAEKANKYL
MSMEG_6440|M.smegmatis_MC2_155 GSGATAVTLIPSLVNGG--AAHVTMLQRSPTYIGSLPLVDPVAEKTNKYL
TH_1149|M.thermoresistible__bu GSGATAVTLIPALAETG--AGHVTMLQRSPTYIGSLPLVDPIAVKVNKYL
Mvan_5683|M.vanbaalenii_PYR-1 GSGATAVTLIPALANSG--AGHVTMLQRSPTFIAALPDVDPFTVATNKRL
MLBr_00065|M.leprae_Br4923 GSGATAVTLVPALANSG--AKHVTMLQRSPTYIVSQPAKDKIAARLNRWL
MAV_4576|M.avium_104 GSGATAVTLLPSLSDR---AAKVTMLQRSPTYLISASKYGKVAAVARKVL
MAB_2654|M.abscessus_ATCC_1997 GSGATAITLIPSMLKGDDAAEHVTMLQRTPTYIMSMPRTDALSLKLTRLL
Rv3741c|M.tuberculosis_H37Rv ------------------------------------------------MI
Mb3767c|M.bovis_AF2122/97 ------------------------------------------------MI
MMAR_5279|M.marinum_M GSGATAVTLVPAMAETAG---HVTMLQRSPTYIIPVPSKDRIANTLPKLV
MUL_4352|M.ulcerans_Agy99 GSGATAVTLVPAMAETAG---HVTMLQRSPTYIIPVPSKDRIANTLPKLV
:
Mflv_0962|M.gilvum_PYR-GCK PGSLAHFVNRWKAISFSTLQYQLSQRFPKYMRKTLMTMAQRRLPEGYDVE
MSMEG_6440|M.smegmatis_MC2_155 PKNLAHFVNRWKAIAFSTAQYQLARKFPNYMRKTLMTMAQRRLPEGFDVQ
TH_1149|M.thermoresistible__bu PPKMASVVNRWKAIIFSTFQYQLSRKFPNYMRRTLMRMAERRLPPGYDVE
Mvan_5683|M.vanbaalenii_PYR-1 PAKVAYVLNRWKSILQQSVQYQVARKFPDFFRKQLLTMAKHRLPEGYDVN
MLBr_00065|M.leprae_Br4923 PDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPKGYDVQ
MAV_4576|M.avium_104 PRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPPGYAVD
MAB_2654|M.abscessus_ATCC_1997 GERRGYLATRWKNVLLDWVVVELMTRFPKAARRLIRHLNTKELPAGFDVD
Rv3741c|M.tuberculosis_H37Rv GRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPAD
Mb3767c|M.bovis_AF2122/97 GRDRAYAVTRRKDIAKQRLVWRLCQRYPRAARRLIRHLNAKQLAAGYPAD
MMAR_5279|M.marinum_M GRKRAYALTRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGYPVD
MUL_4352|M.ulcerans_Agy99 GRKRAYALTRKKNVAKQRLVWHFCQRYPGAARRVIRHLNARLLPTGYPVD
. * . : * * : . *. *: .:
Mflv_0962|M.gilvum_PYR-GCK KHFGPRYNPWDERLCLAPNGDLFKTIRAGKADVVTDTIDRFTETGIRLNS
MSMEG_6440|M.smegmatis_MC2_155 KHFGPRYNPWDERLCLAPNGDLFKTIRAGKADVVTDTIAKFTETGIKLTS
TH_1149|M.thermoresistible__bu KHFGPRYNPWDERLCLAPNGDLFRAIRHGKADVVTDTIDTFTKTGIRLTS
Mvan_5683|M.vanbaalenii_PYR-1 KHFNPRYNPWDERVCLAPNGDLFKTIRAGKADVVTDTIERFTKTGIQLAS
MLBr_00065|M.leprae_Br4923 KHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIRLKS
MAV_4576|M.avium_104 IHFKPRYNPWDQRMCLIPDADLYNAITAGRADVVTDHIDHFDATGIALRS
MAB_2654|M.abscessus_ATCC_1997 RHFNPPYDPWDQRLCLAPDGDFFTSIREGRASVVTDRIRRFTKNGIELES
Rv3741c|M.tuberculosis_H37Rv EHFKPVYNPWDQRLCAVPDADMFKAIRDGRASVVTEAIDTFTENGIRLQS
Mb3767c|M.bovis_AF2122/97 EHFKPVYNPWDQRLCAVPDADMFKAIRDGRASVVTEAIDTFTENGIRLQS
MMAR_5279|M.marinum_M EHFRPDYNPWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQS
MUL_4352|M.ulcerans_Agy99 EHFRPDYNPWDQRLCAVPDADMFQAIRDGRASVVTDQIETFTERGIRLQS
** * *:**::*:* *:.*:: :* * ..:**: * * ** * *
Mflv_0962|M.gilvum_PYR-GCK GEELAADIIITATGLNMQLFGGATATRNGEPIDLTKTMTYKGLMLSGVPN
MSMEG_6440|M.smegmatis_MC2_155 GEELTADIIITATGLNMQLFGGASLTRNGQEVDLTETMTYKGLMLSGVPN
TH_1149|M.thermoresistible__bu GTELEADIIITATGLNLQLFGGAEIKRNGQPVELTETMAYKGMMLSGMPN
Mvan_5683|M.vanbaalenii_PYR-1 GRHLDADIIVTATGLNLQLFGGATISRNGEAIELNDTMAYKGMLLTDMPN
MLBr_00065|M.leprae_Br4923 GNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMMLSGLPN
MAV_4576|M.avium_104 GAHLDADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHMLEDVPN
MAB_2654|M.abscessus_ATCC_1997 GEELPADVIVTATGLNMRLFGGVDLTVDGRPIDLSSSVVYRGLLLSGLPN
Rv3741c|M.tuberculosis_H37Rv GRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSN
Mb3767c|M.bovis_AF2122/97 GRELAADISITATGLNLLAFGGINLSVDGVAVDVAEKVAFKGFLLSDVSN
MMAR_5279|M.marinum_M GRELEADIIVTATGLNLLAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPN
MUL_4352|M.ulcerans_Agy99 GRELEADIIVTATGLNLLAFGGIGLSVDGEPVDVSQKVAFKGFLLSDVPN
* .* **: :*****:: :** . :* :. . . ::. :* .:.*
Mflv_0962|M.gilvum_PYR-GCK MAITFGYTNASWTLKADLVSEFICRLLNYMDDNGFDRVEAQHPGDSVEEK
MSMEG_6440|M.smegmatis_MC2_155 MAITFGYTNASWTLKADLVSEFICRVLNYMDDNGFDRVEPQHPGDAVDAL
TH_1149|M.thermoresistible__bu MAFTIGYTNASWTLKADLVSEFVCRVLNHMDEHGYDVVEPQHPGDSVEER
Mvan_5683|M.vanbaalenii_PYR-1 LAFTIGYTNASWTLKADLVSEFFCRIINYMDANSYDRVEPRHPGSSVDER
MLBr_00065|M.leprae_Br4923 MIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYPGSDVEER
MAV_4576|M.avium_104 LFWCVGYTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNEPMTEK
MAB_2654|M.abscessus_ATCC_1997 WMMAIGYTKSSWTLKISLLGKSLIELLHHMDTHGYDTVAP-YAAEGVGTR
Rv3741c|M.tuberculosis_H37Rv FAGPHGRT------------------------------RAHHLLS-AAAR
Mb3767c|M.bovis_AF2122/97 FAGPHGRT------------------------------RAHHLLS-AAAR
MMAR_5279|M.marinum_M FAYVFGYTNSSWTLKVGLVCEHFCRLLAHMDANGHNICRPHAPAS-MPTR
MUL_4352|M.ulcerans_Agy99 FAYVFGYTNSSWTLKVGLVCEHFCRLLAHMDANGHNICRPHAPAS-MPTR
* * .
Mflv_0962|M.gilvum_PYR-GCK PFMDFSPGYFRRAMDTLPKSGSEAPWR--LKQNYFIDLRTIRYGKVDEES
MSMEG_6440|M.smegmatis_MC2_155 PFMDFNPGYFRRAMDSLPKSGSRAPWR--LKQNYFFDLRMIRYDKVDEES
TH_1149|M.thermoresistible__bu PLLDFTPGYVLRALDRLPPPXXXRMWWTRCRRSRFAAGPPAWRSTTRRRS
Mvan_5683|M.vanbaalenii_PYR-1 PLMDFTPGYVLRALDYLPKAGSRAPWR--LKQNYLMDLQLIRRGKVDDEA
MLBr_00065|M.leprae_Br4923 PFMDFTPGYVLRSLDALPKQGSRTPWR--LNQNYLRDIRLIRRGKVADEG
MAV_4576|M.avium_104 PSWDINAGYVLRSVHALPKSGTKRPWN--VRQNYLADAIDYRFDRI-EEA
MAB_2654|M.abscessus_ATCC_1997 SILDLDAGYMQRSKHSLPRQGDAMPWQ---MRNVFLEDRKMYRGSIIDDN
Rv3741c|M.tuberculosis_H37Rv -------SHADPAAAGRRSP--------------LADLKVLREGPVDDDH
Mb3767c|M.bovis_AF2122/97 -------SHADPAAAGRRSP--------------LADLKVLREGPVDDDH
MMAR_5279|M.marinum_M PLLEITAGYVKRAAAAFPHQGTEGPWR--TCMDYRADRATLREGPVDDDH
MUL_4352|M.ulcerans_Agy99 PLLEITAGYVKRAAAAFPHQGTEGPWR--TCMDYRADRATLREGPVDDDH
.: : .
Mflv_0962|M.gilvum_PYR-GCK LRFTK---------------HGAPVALSS--------
MSMEG_6440|M.smegmatis_MC2_155 LHFTK---------------HRAAVSASSS-------
TH_1149|M.thermoresistible__bu SRPRP---------------GRWGSTGCG--------
Mvan_5683|M.vanbaalenii_PYR-1 LAFSR---------------HPAQVTASA--------
MLBr_00065|M.leprae_Br4923 LLFAK---------------KTTPVTV----------
MAV_4576|M.avium_104 MVFGR---------------AADRAALAG--------
MAB_2654|M.abscessus_ATCC_1997 LHFSSRLERELKDSGSNSPDRRTQISRASSGGATS--
Rv3741c|M.tuberculosis_H37Rv LRFTTS-------------ASASRLTVKRITRSTPWN
Mb3767c|M.bovis_AF2122/97 LRFTTS-------------ASASRLTVKRITRSTPWN
MMAR_5279|M.marinum_M LQFSAS-------------AAADTPPLALTG------
MUL_4352|M.ulcerans_Agy99 LQFSAS-------------AAADTPPLALTG------
.