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AGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVYHATFTDASRLKAGQKVRIAGVPVGSV KAVKLNPDHSIDVAFAIDRSYTLYSSTRAVIRYENLVGDRFLEITSGPGELRKLPPGGTINVAHTQPALD LDALLGGLRPVLKGFDADKINTITSAVIELLQGQGGPLANVLADTGAFSAALGARDQLIGEVITNLNAVL ATVDAKSAQFSASVDQLQQLVSGLAKNRDPIAGAISPLASTTTDLTELLRNSRRPLQGILENARPLATEL DNRKAEVNNDIEQLGEDYLRLSALGSYGAFFNIYFCSVTIKINGPAGSDILLPIGGQPDPSKGRCAFAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3498c | mce4B | - | 100% (350) | MCE-FAMILY PROTEIN MCE4B |
| M. tuberculosis H37Rv | Rv1967 | mce3B | 5e-66 | 38.69% (336) | MCE-family protein MCE3B |
| M. tuberculosis H37Rv | Rv0170 | mce1B | 2e-57 | 36.76% (340) | MCE-family protein MCE1B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3528c | mce4B | 0.0 | 100.00% (350) | MCE-family protein MCE4B |
| M. gilvum PYR-GCK | Mflv_1557 | - | 1e-132 | 66.67% (342) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02590 | mce1B | 2e-63 | 41.04% (346) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4152c | - | 1e-129 | 65.78% (339) | MCE-family protein |
| M. marinum M | MMAR_4986 | mce4B | 1e-175 | 87.43% (350) | MCE-family protein Mce4B |
| M. avium 104 | MAV_0658 | - | 1e-169 | 84.00% (350) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_5899 | - | 1e-137 | 69.55% (335) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_1936 | - | 1e-133 | 68.36% (335) | MCE-FAMILY PROTEIN MCE4B |
| M. ulcerans Agy99 | MUL_4061 | mce4B | 1e-174 | 86.86% (350) | MCE-family protein Mce4B |
| M. vanbaalenii PYR-1 | Mvan_5201 | - | 1e-130 | 68.06% (335) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3498c|M.tuberculosis_H37Rv MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVYHATFT
Mb3528c|M.bovis_AF2122/97 MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVYHATFT
MMAR_4986|M.marinum_M MASGGMPSHRSMVIKVSVFGVVMLVVAAALVVVFGDFRFGPTNVYHATFT
MUL_4061|M.ulcerans_Agy99 MASGGMPSHRSMVIKVSVFGVVMLVLAAALVVVFGDFRFGPTNVYHATFT
MAV_0658|M.avium_104 MAGSGMPSHRSMVIKVSIFAAAMLLVSAGLVVVFGDFRFGPESTYHATFV
Mflv_1557|M.gilvum_PYR-GCK -----MNRERRTLVSVSIFTVVMLMVAASLIVVFGEFRFAAEDKYRATFT
Mvan_5201|M.vanbaalenii_PYR-1 -----MR--DKTLINVGVFTVAMLLVAAMLVVVFGEFRFASEDKYHATFT
MSMEG_5899|M.smegmatis_MC2_155 -----MHR-DRTMLKVGIFTMVMLLVAAGLVVVFGEFRFAAGQSYHATFS
TH_1936|M.thermoresistible__bu ------------MIKVVVFTIAMVLVAAGLVVVFGEFRFASGRTYHATFT
MAB_4152c|M.abscessus_ATCC_199 -----MKR--ATQIKVIVFTVVMLLVAAGLIITFGEFRFGSGKRYHAMFS
MLBr_02590|M.leprae_Br4923 ------MKLTGTVVRLSIFSLVLLLFTVMIIVVFGQMRFGRTNGYTAEFT
: : :* .:::.:. :::.**::**. * * *
Rv3498c|M.tuberculosis_H37Rv DASRLKAGQKVRIAGVPVGSVKAVKLNPDHS-IDVAFAIDRSYTLYSSTR
Mb3528c|M.bovis_AF2122/97 DASRLKAGQKVRIAGVPVGSVKAVKLNPDHS-IDVAFAIDRSYTLYSSTR
MMAR_4986|M.marinum_M NASRLKAGQKVRIAGVPVGSVKAVDLNPDNT-IDVAFAIDRAYTMYSSTR
MUL_4061|M.ulcerans_Agy99 NASRLKAGQKVRIAGVPVGSVKAVDLNPDNT-IDVAFAIDRAYTMYSSTR
MAV_0658|M.avium_104 DVSRLKAGQKVRIAGVPVGAVEAVKLNRDNT-IDVTFGVDKRYTLYSSTR
Mflv_1557|M.gilvum_PYR-GCK DASRLKTGQDVRIAGIPVGTVEGLSLNPDNS-VEVEFTVNERYQLYTSTK
Mvan_5201|M.vanbaalenii_PYR-1 DASRLKAGQDVRIAGVPVGTVEGLTLNPDNT-VDVAFTVNDRYQLYTSTK
MSMEG_5899|M.smegmatis_MC2_155 EASRLKAGQDVRIAGVPVGTVKSVKLNPDNT-VDVGFDVNKRYQLYTSSR
TH_1936|M.thermoresistible__bu DASRLETGDDVRIAGVPVGTVKSVKLNEDNT-VDVSFDVNKRYQLYTSTR
MAB_4152c|M.abscessus_ATCC_199 TASDLRSGQKVRIAGVPVGRVKNVSLNRDNS-VEVTFDVDSKYQLYSSSR
MLBr_02590|M.leprae_Br4923 NISGLRTGQFVRASGVEVGKVNSVALINGGTRVRVKFNVDRSVPLYQSTT
* *.:*: ** :*: ** *: : * . : : * * :: :* *:
Rv3498c|M.tuberculosis_H37Rv AVIRYENLVGDRFLEITSGPGE--LRKLPPGGTINVAHTQPALDLDALLG
Mb3528c|M.bovis_AF2122/97 AVIRYENLVGDRFLEITSGPGE--LRKLPPGGTINVAHTQPALDLDALLG
MMAR_4986|M.marinum_M AVIRYENLVGDRYLEITSGPGE--LRKLPPGGTINAEHTQPALDLDALLG
MUL_4061|M.ulcerans_Agy99 AVIRYENLVGDRYLEITSGPDE--LRKLPPGGTINAEHTQPALDLDALLG
MAV_0658|M.avium_104 AVIRYENLVGDRYLEITSGPGE--LRKLPAGGTINSQHTQPALDLDALLG
Mflv_1557|M.gilvum_PYR-GCK AVIRYENLVGDRYLEITSGPGD--LVKLPPGGTV--VNTEPALDLDALLG
Mvan_5201|M.vanbaalenii_PYR-1 AVVRYENLVGDRYLEITSGPGD--LVKLPKGGTI--THTEPALDLDALLG
MSMEG_5899|M.smegmatis_MC2_155 AVVRYENLVGDRYLEITSGPGE--LRKLAPGGTLGLQNTQPALDLDALLG
TH_1936|M.thermoresistible__bu ALIRYENLVGDRYLEIASGPGE--LKKLPPGGRIPQTNTQPALDLDALLG
MAB_4152c|M.abscessus_ATCC_199 AIIRYENLVGDRYLEITAGPGE--LHKLPDGGTLDKEHTQPALDLDALLG
MLBr_02590|M.leprae_Br4923 AQIRYLDLIGNRYLELKHGEGQGSEKIMPAGGLIPLSRTSPALDLDALIG
* :** :*:*:*:**: * .: :. ** : .*.********:*
Rv3498c|M.tuberculosis_H37Rv GLRPVLKGFDADKINTITSAVIELLQGQGGPLANVLADTGAFSAALGARD
Mb3528c|M.bovis_AF2122/97 GLRPVLKGFDADKINTITSAVIELLQGQGGPLANVLADTGAFSAALGARD
MMAR_4986|M.marinum_M GLRPVLKGLDADKVNTVTGAVIELLQGQGGALANVLADTSAFSTALARRD
MUL_4061|M.ulcerans_Agy99 GLRPVLKGLDADKVNTVTGAVIELLQGQGGALANVLADTSAFSTALARRD
MAV_0658|M.avium_104 GLRPVLKGLDADKVNTISSAVIQLLQGQGGALSNVLADTSAFTSALGQRD
Mflv_1557|M.gilvum_PYR-GCK GLKPVVKGLDGAKVNEISSAVIELLQGEGGALAAMLSSTSAFTQNLAARD
Mvan_5201|M.vanbaalenii_PYR-1 GLKPVVKGLDGAKINEISNAVIELLQGEGGALSAMLSNTSAFTQNLAARD
MSMEG_5899|M.smegmatis_MC2_155 GLRPVLKGLDGAKINEVSNAVIEMLQGQGGALANMLTSTSAFTQNLAARD
TH_1936|M.thermoresistible__bu GLRPVLKGLEGHKVNEISTAVIQALQGQGGALSELLANTGSFTQRLADRY
MAB_4152c|M.abscessus_ATCC_199 GLRPVLKGFDAAKVNEISNAFIQILQGQGGTLSQLLGDTSSFTSGLAERD
MLBr_02590|M.leprae_Br4923 GFKPLFRALDPDKINTIASAIVAAFQGQGGTINDILDQTAQLTTAIGERD
*::*:.:.:: *:* :: *.: :**:**.: :* .*. :: :. *
Rv3498c|M.tuberculosis_H37Rv QLIGEVITNLNAVLATVDAKSAQFSASVDQLQQLVSGLAKNRDPIAGAIS
Mb3528c|M.bovis_AF2122/97 QLIGEVITNLNAVLATVDAKSAQFSASVDQLQQLVSGLAKNRDPIAGAIS
MMAR_4986|M.marinum_M QLIGDTITNLNSVLATVDQRSAQFSASVDQLQQLITGLAENKDVIAGAIP
MUL_4061|M.ulcerans_Agy99 QLIGDTITNLNSVLATVDQRSAQFSASVDQLQQLITGLAENKDVIAGAIP
MAV_0658|M.avium_104 QLIGDVINNLNTVLTTVDQRSAQFSASVDQLQQLITGLAKHKDDIAGAIP
Mflv_1557|M.gilvum_PYR-GCK QLIGDVITNLNTVLGTVDEKGAEFDASVDQLQKLITGLAEGRDPIAGAIG
Mvan_5201|M.vanbaalenii_PYR-1 QLIGDVINNLNTVLGTVDEKGAEFNASVDQLQKLITGLAEGRDPIAGAIG
MSMEG_5899|M.smegmatis_MC2_155 QLISDVIANLNTVLGTVDEKGAQFDASVDQLQQLITGLAENKDPIAGAIE
TH_1936|M.thermoresistible__bu YVINDVITHLNAVVGTLDEKSAEFDASVDQLQQLITGLAEGRDPIAGALP
MAB_4152c|M.abscessus_ATCC_199 QLIGDVINHLNEVLATVDSKSTQFSSSVDQLQQLISGLAQQRDVVAGALP
MLBr_02590|M.leprae_Br4923 QAIGEVVKNLNVVLDTTVRHRKEFDQTVNNLEILITGLKDHGDQLAGSFA
*.:.: :** *: * : :*. :*::*: *::** . * :**::
Rv3498c|M.tuberculosis_H37Rv PLASTTTDLTELLRNSRRPLQGILENARPLATELDNRKAEVNNDIEQLGE
Mb3528c|M.bovis_AF2122/97 PLASTTTDLTELLRNSRRPLQGILENARPLATELDNRKAEVNNDIEQLGE
MMAR_4986|M.marinum_M PLASTTTDLTELLKNSRRPLQGLLENARPLATELDNRKDEVNNDVEQLGE
MUL_4061|M.ulcerans_Agy99 PLASTTTDLTELLKNSRRPLQGLLENARPLATELDNRKDEVNNDVEQLGE
MAV_0658|M.avium_104 PLASTTTDLTELLQNSRRPLQGVLENTRPLATELDNRKAEVNNDVEQLGE
Mflv_1557|M.gilvum_PYR-GCK PLATAENDLTEMLETSRRPIQGVIENVRPFAQRMDERKADVNKVIEPLAE
Mvan_5201|M.vanbaalenii_PYR-1 PLATAENDLTAMLEASRRPVQGVIENVRPFAQRMDERKGDVNKVIEPLAE
MSMEG_5899|M.smegmatis_MC2_155 PLASAESDLTEMLEKSRRPVQGVIENVRPMAGRMDERKDDINKVIEPLAE
TH_1936|M.thermoresistible__bu PLASAENDLTDMLRNGRRPVQGVLENLRPLATEIDNRKEEVNRVIEPLAE
MAB_4152c|M.abscessus_ATCC_199 PLASTASSLESVLKDTRPYIKGTIEQARQLATRVDERKADVNVVVENLAE
MLBr_02590|M.leprae_Br4923 HISNAAGTVANLLAEDHALLHKSINYLDGIQQPLIDQRLQLEDYLHKLPT
::.: : :* : :: :: : : ::: ::: :. *
Rv3498c|M.tuberculosis_H37Rv DYLRLS-ALGSYGAFFNIYFCSVTIKINGPAGSDILLPIGGQPDPSKGRC
Mb3528c|M.bovis_AF2122/97 DYLRLS-ALGSYGAFFNIYFCSVTIKINGPAGSDILLPIGGQPDPSKGRC
MMAR_4986|M.marinum_M DYLRLA-ALGSYGAFFNIYFCTVTIKINGPAGSDILIPMGGQPDPSKGRC
MUL_4061|M.ulcerans_Agy99 DYLRLA-ALGSYGAFFNIYFCTVTIKINGPAGSDILIPMGGQPDPSKGRC
MAV_0658|M.avium_104 DYLRLA-ALGAYGSFFNIYFCSVTIKINGPAGSDILLPLGGQVDPSKGRC
Mflv_1557|M.gilvum_PYR-GCK NYLRLN-ALGAYGSFFNIFYCSTRLKINGPAGSDILVPFGGPPDPSKGRC
Mvan_5201|M.vanbaalenii_PYR-1 NYLRLN-ALGAYGSFFNIFYCSTRLKINGPAGSDILVPFGGPPDPSKGRC
MSMEG_5899|M.smegmatis_MC2_155 NYLRLN-ALGAYGSFFNIFYCSVRLKVNGPAGSDILIPFGGPPDPSKGRC
TH_1936|M.thermoresistible__bu NYLRLQ-SLGAYGAYFNIFYCSTRIKINGPAGSDILIPFGGPPDPSKGRC
MAB_4152c|M.abscessus_ATCC_199 NYLRLN-ALGAYGSFFNIYYCSIRIKVNGPVGTDWLIPFGGPPDPSKGRC
MLBr_02590|M.leprae_Br4923 VLNQIGRTIGSYGDFVNFYSCDITLKINGLQPGGPVRTVRLFQQP-TGRC
:: ::*:** :.*:: * :*:** . : .. :* .***
Rv3498c|M.tuberculosis_H37Rv AFAK-
Mb3528c|M.bovis_AF2122/97 AFAK-
MMAR_4986|M.marinum_M AFAK-
MUL_4061|M.ulcerans_Agy99 AFAK-
MAV_0658|M.avium_104 AFVK-
Mflv_1557|M.gilvum_PYR-GCK SEDG-
Mvan_5201|M.vanbaalenii_PYR-1 AEVE-
MSMEG_5899|M.smegmatis_MC2_155 SENG-
TH_1936|M.thermoresistible__bu SEDG-
MAB_4152c|M.abscessus_ATCC_199 AFKNE
MLBr_02590|M.leprae_Br4923 TPQ--
: