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TMFARPTIPVAAAASDISAPAQPARGKPQQRPPSWSPRNWPVRWKVFTIALLPLVVAMVLAGLRVEAAMA STSGLRLVAARAEMIPAITKYMSALDVAVLASSTGHDVEGAQKNFTARKYELQTRLADTDVIADVRSGVN TLLNGGQALLDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQE ILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDPAVALVNNPEL LHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVLR DGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVDELHTRALLLAGEETRLRLLVNEMFE TMSRRSRSLVDQQLSVIDQLERNEEDPARLDSLFRLDHLAARLRRNSANLLVLAGAQITRDHREPVPLST VISAAVSEVEDYRRVDIARVPDCAVVGAAAGGVIHLLAELIDNALRYSSPTTPVRVAAAIGSEGSVLLRI SDSGLGMTDADRRMANMRLRAGGEVTPDSARHMGLFVVGRLAGRHGIRVGLRGPVTGEQGTGTTAEVYLP LAVLEGTAPAQPPKPRVFAIKPPCPEPAAADPTDVPAAIGPLPPVTLLPRRTPGSSGIADVPAQPMQQRR RELKTPWWEDRFQQEPKQPPAPEPRPAPPPAKPAPPAGPVDDDVIYRRMLSEMVGDPHELAHSPDLDWKS VWDHGWSAAAEAADKPVQSRTDYGLPVREPGARLVPGAAVPEGPDREHPGAALASNGGLHPGRAPRHAAA VRDPDAVRASISSHFGGVRTGRSHARESSQGPNQQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3365c | - | - | 100% (876) | hypothetical protein Rv3365c |
| M. tuberculosis H37Rv | Rv3876 | - | 1e-09 | 27.63% (257) | hypothetical protein Rv3876 |
| M. tuberculosis H37Rv | Rv0982 | mprB | 2e-09 | 23.16% (367) | two component sensor kinase MprB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3400c | - | 0.0 | 100.00% (876) | hypothetical protein Mb3400c |
| M. gilvum PYR-GCK | Mflv_4889 | - | 0.0 | 51.48% (845) | integral membrane sensor signal transduction histidine kinase |
| M. leprae Br4923 | MLBr_00175 | - | 1e-09 | 22.80% (364) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_1077 | - | 1e-09 | 25.66% (343) | two component sensor kinase MprB |
| M. marinum M | MMAR_1165 | - | 0.0 | 69.04% (914) | putative regultory protein |
| M. avium 104 | MAV_4331 | - | 0.0 | 64.64% (956) | hypothetical protein MAV_4331 |
| M. smegmatis MC2 155 | MSMEG_1637 | - | 0.0 | 47.17% (935) | periplasmic sensor signal transduction histidine kinase |
| M. thermoresistible (build 8) | TH_3044 | - | 1e-174 | 51.99% (629) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_2850 | - | 0.0 | 68.71% (914) | putative regultory protein |
| M. vanbaalenii PYR-1 | Mvan_1536 | - | 0.0 | 49.54% (874) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3365c|M.tuberculosis_H37Rv MTMFARPTIPVAAAASDISAPAQPARGKPQQRPPSWSPRNWPVRWKVFTI
Mb3400c|M.bovis_AF2122/97 MTMFARPTIPVAAAASDISAPAQPARGKPQQRPPSWSPRNWPVRWKVFTI
MMAR_1165|M.marinum_M MTMFARPTTPVEAAPG--APVASGAESAPPKRPPAWSLGNWPVGWKVVAI
MUL_2850|M.ulcerans_Agy99 MTMFARLTTPVEAAPG--APVASGAESAPPKRPPAWSLGNWPVGWKVVAI
MAV_4331|M.avium_104 MTMFSRPAEPAAAEAP--GPAPLGGGAVPAKRPPAWSLSNWPVRWKVLAI
Mflv_4889|M.gilvum_PYR-GCK ----------------------MARSLRPDQRPSRWAPPNWPVRVKVLAL
Mvan_1536|M.vanbaalenii_PYR-1 -----------------------MNDTRSVKRPAPLALSNWPVRVKVLAI
MSMEG_1637|M.smegmatis_MC2_155 ------------------------------------------MSRKVLAI
TH_3044|M.thermoresistible__bu MTVFSQLRKSDGTNRD-----VEPPAPDPIKKPSRWALTNWPVRWKVFAI
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MAB_1077|M.abscessus_ATCC_1997 --------------------------------------------------
Rv3365c|M.tuberculosis_H37Rv ALLPLVVAMVLAGLRVEAAMASTSGLRLVAARAEMIPAITKYMSALDVAV
Mb3400c|M.bovis_AF2122/97 ALLPLVVAMVLAGLRVEAAMASTSGLRLVAARAEMIPAITKYMSALDVAV
MMAR_1165|M.marinum_M AVVPLLLAMVLGGLRIHGGMANSSGLRLADARADVIPAITKYMSALDVAL
MUL_2850|M.ulcerans_Agy99 AVVPLLLAMVLGGLRIHGGMANSSGLRLADARADVIPAITKYMSALDVAL
MAV_4331|M.avium_104 VLVPLMLATVFGVLRIHGAMANAAGLRLAAARADVVPAITKYMSALDVAL
Mflv_4889|M.gilvum_PYR-GCK VTVPLVLACVFGGLRISASTVEARELAHAADRAQMVPAVVDYMAALQNAM
Mvan_1536|M.vanbaalenii_PYR-1 VVVPLLLACVFGGLRIYSSATEAAELRHAAQRADMVPAVVDYMAALEAAM
MSMEG_1637|M.smegmatis_MC2_155 VLVPLILAATFGGLRIYASVTEAADLRLAADRAELIPDINNYMAALEGVL
TH_3044|M.thermoresistible__bu VLVPLLLIATFAGLRVYSGVAENAELRRAVDRAEVIPPVVDYMAALEEAM
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MAB_1077|M.abscessus_ATCC_1997 --------------------------------------------------
Rv3365c|M.tuberculosis_H37Rv LASSTGHDVEGAQKNFTARKYELQTRLADTDVIADVRSGVNTLLNGGQAL
Mb3400c|M.bovis_AF2122/97 LASSTGHDVEGAQKNFTARKYELQTRLADTDVIADVRSGVNTLLNGGQAL
MMAR_1165|M.marinum_M LASSTGRDVEGPKKNFAARKNELQTRLANTNVLSDVRSGVNSVLNGGQAL
MUL_2850|M.ulcerans_Agy99 LASSTGRDVEGPKKNFAARKNELQTRLANTNVLSDVRSGVNSVLNGGQAL
MAV_4331|M.avium_104 LAGSAGRDAEGAKKNYEARKNELQTRLGDTDVTDDVRAGVNNLLDTGQML
Mflv_4889|M.gilvum_PYR-GCK VTAGGGGNPAAALGEFDFRKAELSRVLEGADVDDSVRLATNTLLEYGQNL
Mvan_1536|M.vanbaalenii_PYR-1 VTATEGGDARQALTVFESRRTGLQHLLDVTPVDDGVRLATNTLIDFGQNL
MSMEG_1637|M.smegmatis_MC2_155 VASSGAGDGQAALATFDSRKSELQQRVDSTDVLGDVREAVGTMLDKGQTL
TH_3044|M.thermoresistible__bu VAATTGRETQPALARFDERKTELRERAEQGEIVPDVRAAVDTLLDGGQDL
MLBr_00175|M.leprae_Br4923 -----------------MVRFAWRRRAS-------LRATSS-LSLRWR--
MAB_1077|M.abscessus_ATCC_1997 ---------------MSTLRMPRRMRDSSTAIFTPLRATSSSVSLRWR--
: :* . : :
Rv3365c|M.tuberculosis_H37Rv LDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRA
Mb3400c|M.bovis_AF2122/97 LDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRA
MMAR_1165|M.marinum_M LDQTLANTISLRDRVTAYVPLLLTAEDAINASVRVDNEQIRAEVQGLSRA
MUL_2850|M.ulcerans_Agy99 LDQTLANTSSLRDRVTAYVPLLLTAEDAINASVRVDNEQIRAEVQGLSRA
MAV_4331|M.avium_104 VNKVAEGSLGLRERVTFYAPILLTAENVINASVRVDDERIRAQAQGLSRA
Mflv_4889|M.gilvum_PYR-GCK LDRIGAAEMNLRTQVMTFGPLLITAQTALTGSVGSDEDSVRTEADVLSRA
Mvan_1536|M.vanbaalenii_PYR-1 IDKISADAIDLRTRVMTYAPLLITSETAITGLVGADDERVRSDADTLSRA
MSMEG_1637|M.smegmatis_MC2_155 VDASMANTVGLRQRILDYAPLLLTAEAAVTGSTHSADQRVQTEAEALGRA
TH_3044|M.thermoresistible__bu INKVMSNVVDLRQRVTAYAPLLLTAETAITGSARDDAPGVQRKAEALSRA
MLBr_00175|M.leprae_Br4923 VMLLAMSMVAMVVVLMAFAVYVVISAALYS--------DIDNQLQSRAQL
MAB_1077|M.abscessus_ATCC_1997 VMLLAMSMVAMVVVLMAVASYLLVSTALYR--------DVDKQLNDRANL
: : : :: : : . : ..
Rv3365c|M.tuberculosis_H37Rv VGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAG
Mb3400c|M.bovis_AF2122/97 VGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAG
MMAR_1165|M.marinum_M VGARGQMTLQEILVTRGAEAPEAQLRNSMITLAGTEPSTLFGMTEVLGVG
MUL_2850|M.ulcerans_Agy99 VGARGQMTLQEILVTRGVEAPEAQLRNSMITLAGTGPSTLFGMTEVLGVG
MAV_4331|M.avium_104 VGARGQMTMQKILVTRGAELPEPQLRTSMATLAGTEPSTLFGMSEVLGAG
Mflv_4889|M.gilvum_PYR-GCK VGARGQMAMQDMLVTRGGELPEPLLRSAMVTLAGTEPATVTAMGTFLGGA
Mvan_1536|M.vanbaalenii_PYR-1 VGARGQMAMQRMLVNSGAELPEPLLRSAMVTIAGTEPATVTAMGGYLGGA
MSMEG_1637|M.smegmatis_MC2_155 IGARGQMTIQEMMVNRGAEEPEPVLRKSMITMAGTEPSTVAALTKVLGSA
TH_3044|M.thermoresistible__bu VGARGQMTMQEMSVTSGGYLPEPELRTSLITLAGTEPSTINGMIAYLGND
MLBr_00175|M.leprae_Br4923 LIASGSLAADPGKAIEGTAYS---DVNAMLVNPGHSIYTANQPGQTLPVG
MAB_1077|M.abscessus_ATCC_1997 LIGSGLLSVDPRRAIEGTAYSA--DVNAKLIFPGLITFSATQQGQTIPYG
: . * :: : . * . .: .* : :
Rv3365c|M.tuberculosis_H37Rv SPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTT
Mb3400c|M.bovis_AF2122/97 SPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTT
MMAR_1165|M.marinum_M SPDAKTLHQQMVTRMAIISDPDSVLAGNPQLLQSIQITRGIAEQVINDAT
MUL_2850|M.ulcerans_Agy99 SPDAKTLHQQMVTRMAIISDPDSVLAGNPQLLQSIQITRGIAEQVINDAT
MAV_4331|M.avium_104 SPEAKTLQQQMVSRMAIMSDPASVLVDNPDLLRSIQTTDDIADQVIKNTT
Mflv_4889|M.gilvum_PYR-GCK SDRADALRSQMVRRMSLLSDPAVVLVGNPELLMSQKITADIAQSLINRIA
Mvan_1536|M.vanbaalenii_PYR-1 TEQASTLRSEMVKRMALLSEPTTALVGNPELLASQKITGDIAAGLIAQTT
MSMEG_1637|M.smegmatis_MC2_155 SDDATTLRDEMVKRMAIMANPGIPLVGNPVLLESLENTRKIAEQIITDNT
TH_3044|M.thermoresistible__bu SQQAATLRTEMVRRMSMMSDPAVPLAANPELLGSQQVTRSVADAMIAELA
MLBr_00175|M.leprae_Br4923 TAEKAVIRGELFMSQRTASD-----------------QRILAIHLPNDSS
MAB_1077|M.abscessus_ATCC_1997 TPEQAVTRGDLQQSLRTVNH-----------------QRVLALRLDNGST
: : :: . :* : :
Rv3365c|M.tuberculosis_H37Rv EAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVL
Mb3400c|M.bovis_AF2122/97 EAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVL
MMAR_1165|M.marinum_M ESVTKAVQARASARRDAAIRDTVFVLGAILVAVVVVLLVARALVRPLRQL
MUL_2850|M.ulcerans_Agy99 ESVTKAVQARASARRDAAIRDTVLVLGAILVAVVVVLLVARALVRPLRQL
MAV_4331|M.avium_104 ASVTKSVHAQAAERRNSAILDTALVLAAIVIALAVVLLVARALVRPLRTL
Mflv_4889|M.gilvum_PYR-GCK DEIPARVSRQADDARTAAIRDSVLVGAAILVALILVLWVARSLVRPLRTL
Mvan_1536|M.vanbaalenii_PYR-1 EDIPAAVARQADDARTAAIRDAALVGAAILVALILVTLVARSMVRPLRTL
MSMEG_1637|M.smegmatis_MC2_155 SAIPAAVEAEAADARNDAIRDSVLVALAVISALVVVLLVARSLVRPLRTL
TH_3044|M.thermoresistible__bu TTIPDEVRQAADDQRTAAIRDTVLVLLAIAVAAVVVLLVARSLVRPLRTL
MLBr_00175|M.leprae_Br4923 LLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRL
MAB_1077|M.abscessus_ATCC_1997 LIMAKSLDPTDTVLRRLGWVLLIVGGVGVAVAAAAGAMVAGTGLRPVARL
:. : . .: * *: : : *: *
Rv3365c|M.tuberculosis_H37Rv RDGALKVAHTDLDGEIAAVRAG-DEPIPEPLAVYTTEEIGQVAHAVDELH
Mb3400c|M.bovis_AF2122/97 RDGALKVAHTDLDGEIAAVRAG-DEPIPEPLAVYTTEEIGQVAHAVDELH
MMAR_1165|M.marinum_M RDGALKVAHTDLEGEIAKVRAG-AEPIPEPLPVYTTEEIGQVAHAVDELH
MUL_2850|M.ulcerans_Agy99 RDGALKVAHTDLEGEIAKVREG-AEPIPEPLPVYTTEEIGQVAHAVDELH
MAV_4331|M.avium_104 RDGALKVAHTDLEEEIAHVKAGGAEPIPAPLPVYTTEEIGQVAHAVDELH
Mflv_4889|M.gilvum_PYR-GCK RDSALRVAHDDLGREVERVRDDGKEFAVDPIPVHTTEEVGQVAHAVDELH
Mvan_1536|M.vanbaalenii_PYR-1 RDSALKVAHEDLPREVEHVRSDGKEFPVQPIPVHTTEEVGQVAHAVDELH
MSMEG_1637|M.smegmatis_MC2_155 RDGALKVAHEDLAKEIERVRAGGEPGPITPLPVYTSEEVGQVAHAVDELH
TH_3044|M.thermoresistible__bu RDSALKVAHGDLARELDQVRETGELPEVEPIAVHTTEEIGQVAHAVDELH
MLBr_00175|M.leprae_Br4923 TEAAERVARTD---------------DLRPIPVFGSDELARLTEAFNLML
MAB_1077|M.abscessus_ATCC_1997 TDAAERVARTD---------------DLRPIAVTGSDELARLTISFNTML
:.* :**: * *:.* ::*:.::: :.: :
Rv3365c|M.tuberculosis_H37Rv TRALLLAGEETRLRLLVNEMFETMSRRSRSLVDQQLSVIDQLERNEEDPA
Mb3400c|M.bovis_AF2122/97 TRALLLAGEETRLRLLVNEMFETMSRRSRSLVDQQLSVIDQLERNEEDPA
MMAR_1165|M.marinum_M AQVLVLAGDEARLRSLVNDMFETMSRRSRSLVDQQLSLIDGLERNEEDPE
MUL_2850|M.ulcerans_Agy99 AQVLVLAGDEARLRSLVNDMFETMSRRSRSLVDQQLSLIDGLERNEEDPD
MAV_4331|M.avium_104 TQALLLAGDEARLRLLVNDMFETMSRRSRSLVDQQLALIDRLERNEDNPE
Mflv_4889|M.gilvum_PYR-GCK QQALVLAGAQARLQLQVTDMFETLSRRNRSLVEQQLSLIDGLERDEEDPD
Mvan_1536|M.vanbaalenii_PYR-1 QQAVMLAGEQARLQLQVTDMFETLSRRNRSLVDQQLSLIDRLERDEEDPD
MSMEG_1637|M.smegmatis_MC2_155 EQAVFLAGEQAQLQLQVADMFETLSRRSRSLVDQQLSLIDELERNEDDPQ
TH_3044|M.thermoresistible__bu EQAVFLAGEQTRLQMQISDMFETLSRRSRSLVDQQLALIDQLERNEEDPQ
MLBr_00175|M.leprae_Br4923 RALAESRERQARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQE
MAB_1077|M.abscessus_ATCC_1997 RALAESRDRQARLVTDAGHELRTPLTSLRTNTELLMAAMQPGAPRLPDEE
:::* . :.* *: .: :: : :
Rv3365c|M.tuberculosis_H37Rv RLDSLFRLDHLAARLRRNSANLLVLAGAQITRDHREPVPLSTVISAAVSE
Mb3400c|M.bovis_AF2122/97 RLDSLFRLDHLAARLRRNSANLLVLAGAQITRDHREPVPLSTVISAAVSE
MMAR_1165|M.marinum_M RLDTLFRLDHLAARLRRNSANLLVLAGAQISRDHREPVPLLTVISAAVSE
MUL_2850|M.ulcerans_Agy99 RLDTLFRLDHLAARLRRNSANLLVLAGAQISRDHREPVPLLTVISAAVSE
MAV_4331|M.avium_104 RLDNLFRLDHLAARLRRNSANLLVLAGAKLARDQRDPVPLATVINAAVSE
Mflv_4889|M.gilvum_PYR-GCK RLQSLFQLDHLAARMRRNGANLLVLAGARISHDRAEPVAVAAIVNAAASE
Mvan_1536|M.vanbaalenii_PYR-1 RLESLFRLDHLAARMRRNGSNLMVLAGAQISRERAESVPVTALVNAAASE
MSMEG_1637|M.smegmatis_MC2_155 RLNSLFRLDHLAARMRRNGANLLVLSGAKVTREKSEPVAVATVINAAASE
TH_3044|M.thermoresistible__bu RLQNLFRLDHLAARMRRNGANLLVLAGAKVPREQAAPMPVASLIHAAASE
MLBr_00175|M.leprae_Br4923 MADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDMSEVLYRSLER
MAB_1077|M.abscessus_ATCC_1997 MQALQQDVIAQIEELSTLVGDLVDLARGDGADIVHEPVDMVEVVEGTLER
: .: .:*: *: .: : :: : ..
Rv3365c|M.tuberculosis_H37Rv VEDYRRVDIARVPDC--AVVGAAAGGVIHLLAELIDNALRYSSPTTPVRV
Mb3400c|M.bovis_AF2122/97 VEDYRRVDIARVPDC--AVVGAAAGGVIHLLAELIDNALRYSSPTTPVRV
MMAR_1165|M.marinum_M VEDYRRVETGGVADC--TVIGAAAGAVIHLLAELIDNALNYSPPTAPVRV
MUL_2850|M.ulcerans_Agy99 VEDYRRVETGGVADC--TVIGAAAGAVIHLLAELIDNALNYSPPTAPVRV
MAV_4331|M.avium_104 VEDYRRVEIAGLPEC--SLLGAAAGGAIHLFAELIDNALRYSPPTTSARV
Mflv_4889|M.gilvum_PYR-GCK VEEYPRIVTGDLPDS--EVAASAAGDLVHLLAELLDNGLRYSPPHTQVRV
Mvan_1536|M.vanbaalenii_PYR-1 VEDYTRIVTTGLPDG--EVDGVVAGDLVHLLAELLDNALRYSPPTTEVRV
MSMEG_1637|M.smegmatis_MC2_155 VEDYTRVVTSDVADA--DVVGSAAGDLIHLLAELLDNALRYSPPTSQVRV
TH_3044|M.thermoresistible__bu VEDYTRIVMTTVPDS--EVHGSVAGDLVHILAELLDNALRYSPPTAQVRV
MLBr_00175|M.leprae_Br4923 VRRRRNDIHFDVQAIGWQIYGDAAG-LSRAVLNLMDNAAKWSPSGGRVVV
MAB_1077|M.abscessus_ATCC_1997 VRRRRNDIEFDVVMQPWQVYGDAAG-LSRAVLNLLDNAAKWSPSGTAVSV
*. . : : . .** : . :*:**. .:*.. . *
Rv3365c|M.tuberculosis_H37Rv AAAIGSEGSVLLRISDSGLGMTDADRRMANMRLRAGGEVTP----DSARH
Mb3400c|M.bovis_AF2122/97 AAAIGSEGSVLLRISDSGLGMTDADRRMANMRLRAGGEVTP----DSARH
MMAR_1165|M.marinum_M SAVRGSEGGVLLRIADSGLGMTESDRRMANMRLHAGVEVTP----ANARH
MUL_2850|M.ulcerans_Agy99 SAVRGSEGGVLLRIADSGLGMTESDRRMANMRLHSGGEVTP----ANARH
MAV_4331|M.avium_104 SASRGGDGGVVVRIADSGLGMNDADRRIANMRLQAGGDANPDPHPENARH
Mflv_4889|M.gilvum_PYR-GCK SAVPTDNNGLVIEVSDTGLGMTEADLRVANMRLESGGEVNP----YTARH
Mvan_1536|M.vanbaalenii_PYR-1 SAVPTGNNGLVIEVSDTGLGMTESDLRVANTRLESGGEVNP----YTARH
MSMEG_1637|M.smegmatis_MC2_155 SAVFAGNGALVIEVADVGLGMTESDLRVANIRLKSGGEVNP----YTARH
TH_3044|M.thermoresistible__bu SAGHADTGALVIEVSDAGLGMSESDLRMANARLESXX-------------
MLBr_00175|M.leprae_Br4923 TMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYRSTTARS----LPGSG
MAB_1077|M.abscessus_ATCC_1997 RLAQVDAAHAELVISDHGPGIPPAERDLVFERFYRATPARG----MPGSG
. : ::* * *: : :. *:
Rv3365c|M.tuberculosis_H37Rv MGLFVVGRLAGRHGIRVGLRGPVT-----GEQGTGTTAEVYLPLAVLEG-
Mb3400c|M.bovis_AF2122/97 MGLFVVGRLAGRHGIRVGLRGPVT-----GEQGTGTTAEVYLPLAVLEG-
MMAR_1165|M.marinum_M MGLFVVGRLAARHGIRVGLRGPST-----GEAGGGTTAEVYLPRTVLVDG
MUL_2850|M.ulcerans_Agy99 MGLFVVGRLAARHGIRVGLRGPST-----GEAGGGTTAEVYLPRTVLVDG
MAV_4331|M.avium_104 LGLFVVGRIAAWHGMRVGLRGPAA-----NESGSGTTAEVYLPPTVLAG-
Mflv_4889|M.gilvum_PYR-GCK MGLFVVSRLAAQHGLVARLRSTVA-----GQPDSGTTAGVYIPARLLVR-
Mvan_1536|M.vanbaalenii_PYR-1 MGLFVVGRLAASHGLVVRLRSTVA-----GEPDSGTTAGVYIPARLLIH-
MSMEG_1637|M.smegmatis_MC2_155 MGLFVVGRLADQHGLVVRLRSTIP-----DEPGSGTTAGVYVPAQLLVT-
TH_3044|M.thermoresistible__bu ----XAGRRCPGRAPTPRVGCRAH-----TCPHCGSRA---PPAQ-----
MLBr_00175|M.leprae_Br4923 LGLAIVKQVVINHGGLLRVEDTAP-----GVQPPGTSIYVLLPG------
MAB_1077|M.abscessus_ATCC_1997 LGLAIVKQVVLKHGGAIKVEETDPGAVIDGEPAPGTSMHVLLPG------
. : :. : *: *
Rv3365c|M.tuberculosis_H37Rv ----TAPAQPPKPRVFA---IKPPCPEPAAA------DPTDVPAAIGP--
Mb3400c|M.bovis_AF2122/97 ----TAPAQPPKPRVFA---IKPPCPEPAAA------DPTDVPAAIGP--
MMAR_1165|M.marinum_M QRPGPAAGQPPQRRAVV---VRPPSSEPAPAPDAAGSAPTGDSTAVPP--
MUL_2850|M.ulcerans_Agy99 QRPGSAAGQPPQRSAFV---VRPPSSEPAPAPDAAGSAPTGDSTAVPP--
MAV_4331|M.avium_104 -RVVAEPSGPRHIRAVSSPSAKLASAIAAPAEEGGRHDGTQQPAARGTRN
Mflv_4889|M.gilvum_PYR-GCK ---RA----APPVQARD---VRPAAPAPAP-------TPAPAPAP-PPPP
Mvan_1536|M.vanbaalenii_PYR-1 ---TA----PAQYGGRD---DEPVPADAHAGIATALALEVPAGVPREAPA
MSMEG_1637|M.smegmatis_MC2_155 ---EAGTAGTPAFDQFD---AQPEDAATAPGHPTGYPNVVSLDTRFVTTG
TH_3044|M.thermoresistible__bu ---------PPGSEQQG---GEPPVEHLTVG-------------------
MLBr_00175|M.leprae_Br4923 ---------------------RPMPVSAYS--------------------
MAB_1077|M.abscessus_ATCC_1997 ---------------------RPGPIVR----------------------
.
Rv3365c|M.tuberculosis_H37Rv -----LPPVTLLPRRTPGSSGIADVP---AQPMQQ----RRRELKTPWWE
Mb3400c|M.bovis_AF2122/97 -----LPPVTLLPRRTPGSSGIADVP---AQPMQQ----RRRELKTPWWE
MMAR_1165|M.marinum_M -----LPPVSLLPRRNPGSSGIADVPG--QQPEQQQPPRRRRELKTPWWE
MUL_2850|M.ulcerans_Agy99 -----LPPVSLLPRRNPGSSGIADVPG--QQPEQQQPPRRRRELKTPWWE
MAV_4331|M.avium_104 TGDASTPPVTLLPRRNPGSSGIADVAAVPAPPAEPQPRRQRRELATPWWE
Mflv_4889|M.gilvum_PYR-GCK APVVP--PADVLPQRRP---------------EPPPPVEPP---------
Mvan_1536|M.vanbaalenii_PYR-1 AAAGP--ATDLLPQRRPGASGIVETP----AETPVAPIETPVATSVAVVT
MSMEG_1637|M.smegmatis_MC2_155 SEHDDDLAAGLLPQRNPGASGISEMPGVFAEPEPAAEVSGDAQGEWPQQW
TH_3044|M.thermoresistible__bu ------IADGVHQRAQP---------------QHPAPVTGER--------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MAB_1077|M.abscessus_ATCC_1997 --------------------------------------------------
Rv3365c|M.tuberculosis_H37Rv DR----------FQQEPKQPPAP-------------------------EP
Mb3400c|M.bovis_AF2122/97 DR----------FQQEPKQPPAP-------------------------EP
MMAR_1165|M.marinum_M TA----------QPAGQPEQAAPQ----QSDTAAFFARRSPAAGAGPDEP
MUL_2850|M.ulcerans_Agy99 TA----------QPAGRPEQAAPQ----QSDTAAFFARRSPAAGAGPDEP
MAV_4331|M.avium_104 ASPAPRPAPEPQQPAPEPQQPAPRPARAASDTSAFFAARPRTETPPETPP
Mflv_4889|M.gilvum_PYR-GCK -------------PPVETPP------------------------PVETP-
Mvan_1536|M.vanbaalenii_PYR-1 PAATPVAAVTPVAPPVETPPARSEVAAFFSPRPQ----------PTETNG
MSMEG_1637|M.smegmatis_MC2_155 PAPQEAAAPEEVAPQANGRPTDTSSFFASRAQAAGGTQNGAQVNGVHLDG
TH_3044|M.thermoresistible__bu --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MAB_1077|M.abscessus_ATCC_1997 --------------------------------------------------
Rv3365c|M.tuberculosis_H37Rv RPAPPPAK-----------------PAPPAGPVDDDVIYRRMLSEMVGDP
Mb3400c|M.bovis_AF2122/97 RPAPPPAK-----------------PAPPAGPVDDDVIYRRMLSEMVGDP
MMAR_1165|M.marinum_M APSVKPGP-----------------PSALADPARDDSIYQKMLSEMTSDP
MUL_2850|M.ulcerans_Agy99 APSVKPGP-----------------PSVPADPVRDDSIYQKMLSEMTSDP
MAV_4331|M.avium_104 EAPPKPAPKPK--------PEASIPPAASTGPADDDVIYRRMLSEMLGDP
Mflv_4889|M.gilvum_PYR-GCK --RPGHAD-----------------------IDHDDTIYQKMLSEWLVDP
Mvan_1536|M.vanbaalenii_PYR-1 HARHAAAD-----------------------SDPDDAIYQKMLSEWLVDP
MSMEG_1637|M.smegmatis_MC2_155 AHTNGAANGTADSFTGFFGSSDDQLDQREPAGDPGDSIYQSMVSEFAIDP
TH_3044|M.thermoresistible__bu --------------------------------------FGGLDVQFAVEG
MLBr_00175|M.leprae_Br4923 -----------------------------------TLADQDMGEANFQDK
MAB_1077|M.abscessus_ATCC_1997 ---------------------------------------PNMGDTAGRRN
:
Rv3365c|M.tuberculosis_H37Rv HELAHSPDLDWKSVWDHGWSAAAEAADKPVQSR-TDYGLPVREPGARLVP
Mb3400c|M.bovis_AF2122/97 HELAHSPDLDWKSVWDHGWSAAAEAADKPVQSR-TDYGLPVREPGARLVP
MMAR_1165|M.marinum_M HELANSADLDWRSVWDRGWSAAAEAQDTPVQSR-TDHGLPVRTPGARLVP
MUL_2850|M.ulcerans_Agy99 HELANSADLDWRSVWDRGWSAAAEAQETPVQSR-TDHGLPVRTPGARLVP
MAV_4331|M.avium_104 HDLVNSPDLDWQSVWDRGWTLAAAAEDKPVESHTTDHGLPVRTPGARLVP
Mflv_4889|M.gilvum_PYR-GCK HELSHSSDLNWKSVWDNGWSAAEAADAAPVRHR-TPEGLPVRRPGARLIP
Mvan_1536|M.vanbaalenii_PYR-1 HELSHSTDLNWKSVWDHGWSAAEAAEAAPVLDH-TAEGLPVRRPGARLVP
MSMEG_1637|M.smegmatis_MC2_155 TTHARSADLDWQTVWEKGWSVAAAAQDAPVDRH-TEEGLPMRTPGARLVP
TH_3044|M.thermoresistible__bu VALVHR----------AGVVAGLPAEHGDQVGQ-QAGGLRQRQPDG----
MLBr_00175|M.leprae_Br4923 IGPAVQVSGKSANFRDSAHVISVDYQSARAR-------------------
MAB_1077|M.abscessus_ATCC_1997 SGP-------------NAREISVDSQSVPAAWRPS---------------
. .
Rv3365c|M.tuberculosis_H37Rv GAAVPEGPDREHPGAALASN--------------------GGLHPGRAPR
Mb3400c|M.bovis_AF2122/97 GAAVPEGPDREHPGAALASN--------------------GGLHPGRAPR
MMAR_1165|M.marinum_M GAADSDEPNQDEADRPPASD--------------------RGLPPDQPAQ
MUL_2850|M.ulcerans_Agy99 GAADSDEPTQDEADRPPASD--------------------RGLPPDQPAQ
MAV_4331|M.avium_104 GGAHG---AAAEPDDEPGLN--------------------GRSPAPRRPQ
Mflv_4889|M.gilvum_PYR-GCK G------------------------------------------HADTENG
Mvan_1536|M.vanbaalenii_PYR-1 G------------------------------------------HANGEP-
MSMEG_1637|M.smegmatis_MC2_155 GGVAAAAGRTNGANGHHHSDLNGGVNGEIHGNDNGAEAVASANEADNGMF
TH_3044|M.thermoresistible__bu --------------------------------------------------
MLBr_00175|M.leprae_Br4923 --------------------------------------------------
MAB_1077|M.abscessus_ATCC_1997 --------------------------------------------------
Rv3365c|M.tuberculosis_H37Rv HAAAVRDPDAVRASISSHFGGVRTGRSHARESSQGPNQQ
Mb3400c|M.bovis_AF2122/97 HAAAVRDPDAVRASISSHFGGVRTGRSHARESSQGPNQQ
MMAR_1165|M.marinum_M HTAAMRDPNAVRASMSSHFGGVHTGRAHAHRASQEPDQQ
MUL_2850|M.ulcerans_Agy99 HTAAMRDPNAVRASMSSHFGGVHTGRAHAHRASQEPDQQ
MAV_4331|M.avium_104 HAAVARDPEAVRASFSSHFGGVRTGRSHARESSEGPDQQ
Mflv_4889|M.gilvum_PYR-GCK HPLPVRDPDAVRASLGGHFGGVHAGRRHAREAAGDDR--
Mvan_1536|M.vanbaalenii_PYR-1 VASAGRDPEAVRNSIGSHFGGVHAGRLRAQETGGADFP-
MSMEG_1637|M.smegmatis_MC2_155 AAFKPRDPEAVRASISSHFGGVHAGRSHARETRGTDNE-
TH_3044|M.thermoresistible__bu -------VPAVDQPLP-------AGT-------------
MLBr_00175|M.leprae_Br4923 ---------------------------------------
MAB_1077|M.abscessus_ATCC_1997 ---------------------------------------