For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ERMRIRAAGISATDPHARLPLPLARDEIRYLGTTFNDLLQRLQDALERERQFVSDAGHELRTPLAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2998A | - | - | 100% (67) | hypothetical protein Rv2998A |
| M. tuberculosis H37Rv | Rv0601c | - | 2e-13 | 53.62% (69) | two component sensor kinase |
| M. tuberculosis H37Rv | Rv0982 | mprB | 1e-07 | 40.30% (67) | two component sensor kinase MprB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3023c | - | 1e-33 | 100.00% (67) | hypothetical protein Mb3023c |
| M. gilvum PYR-GCK | Mflv_1888 | - | 4e-08 | 40.30% (67) | integral membrane sensor signal transduction histidine kinase |
| M. leprae Br4923 | MLBr_00175 | - | 4e-08 | 40.30% (67) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 8e-07 | 51.06% (47) | putative two component sensor kinase |
| M. marinum M | MMAR_4528 | mprB | 7e-08 | 41.79% (67) | two-component sensor kinase MprB |
| M. avium 104 | MAV_3405 | - | 4e-12 | 46.27% (67) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_5487 | - | 4e-08 | 41.79% (67) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 4e-08 | 40.30% (67) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_4700 | mprB | 5e-08 | 41.79% (67) | two component sensor kinase MprB |
| M. vanbaalenii PYR-1 | Mvan_3840 | - | 8e-09 | 52.00% (50) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 ---------------MFSGGP---RACRIEGVHLGISARSAAVAAIVVFC
MSMEG_5487|M.smegmatis_MC2_155 MASATCCGKRLRSEMAFPPNS-WRPTGPLPTSSLSLRWRVMMLAMSMVAL
TH_2428|M.thermoresistible__bu ----------MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLLAMSMVAM
Mflv_1888|M.gilvum_PYR-GCK MAGD-------PNTATWPPQP--PGPPPPPASSISLRWRVMLLAMSMAVI
MMAR_4528|M.marinum_M -------------MVGFRRGP---RAPLRATSSLSLRWRVMLLAMSMVAM
MUL_4700|M.ulcerans_Agy99 -------------MVGFRRGP---RAPLRATSSLSLRWRVMLLAMSMVAM
MLBr_00175|M.leprae_Br4923 -------------MVRFAWRR---RASLRATSSLSLRWRVMLLAMSMVAM
Mvan_3840|M.vanbaalenii_PYR-1 ------------------------MTPRSPARRSTIRWRLTVLYGSAFFI
MAB_2582|M.abscessus_ATCC_1997 -----------------------------MNRFLNTQLDEQVRDAGNRSV
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 ALTVAGAGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNALLT
MSMEG_5487|M.smegmatis_MC2_155 VVVLMAVAVYAVVSRALYDDLDNQLHSRARLLI--ESGSLAADPGKAIEG
TH_2428|M.thermoresistible__bu VVVLMSIALYAVVSRALYNDIDNQLHSRARLLI--ESGSLAADPGRAIEG
Mflv_1888|M.gilvum_PYR-GCK PVVLMGVAGYAVVSRALYDDIDDQLRTRAQMLI--ESGSLDADPGKAIEG
MMAR_4528|M.marinum_M VVVLMSFAVYAVISAALYSDIDNQLQSRAQLLI--ASGSLAADPGKAIEG
MUL_4700|M.ulcerans_Agy99 VVVLMSFAVYAVISAALYSDIDNQLQSRAQLLI--ASGSLAADPGKAIEG
MLBr_00175|M.leprae_Br4923 VVVLMAFAVYVVISAALYSDIDNQLQSRAQLLI--ASGSLAADPGKAIEG
Mvan_3840|M.vanbaalenii_PYR-1 AGAVLICLMYVFLQQSLHNRPAGAQGVVSQFLD--DRG------------
MAB_2582|M.abscessus_ATCC_1997 VLFELGPPPPLSLPRPLANGWRPTDGPGPAFLD---------APGQSIGM
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 TDQRVVATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSG
MSMEG_5487|M.smegmatis_MC2_155 TAYSDVNAMLVIPGRSIYTANQQGQTLPLGEPEKD--VISGELLMSLRTA
TH_2428|M.thermoresistible__bu TAYSDVNAMLVNPGRSIYTANQQGEALPLGEPERQ--VLSGELVMSLRTA
Mflv_1888|M.gilvum_PYR-GCK TAYSDMNAMFYIPGRSKYTAKQQGQTLPVGRPEQD--VMDGTLWMSLRTV
MMAR_4528|M.marinum_M TAYSDVNAMLVNPGRSIYTANQPGQTLPVGAPEKA--VIHGDLFLSRRTV
MUL_4700|M.ulcerans_Agy99 TAYSDVNAMLVNPGRSIYTANQPGQTLPVGAPEKA--VIHGDLFLSRRTV
MLBr_00175|M.leprae_Br4923 TAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKA--VIRGELFMSQRTA
Mvan_3840|M.vanbaalenii_PYR-1 ------------------------------VRNRP--VVEGLLRAVATES
MAB_2582|M.abscessus_ATCC_1997 VGAVAVNGHVTEAARITADGSRERLSPQACREVEG--LLQQSTSTVDLDH
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 DDMRVSGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVAVA
MSMEG_5487|M.smegmatis_MC2_155 NHQRVLAVHLANGS---SLLISKSLAPTVQVLRRLGTVLLIVGGIGVAVA
TH_2428|M.thermoresistible__bu DQQRVLAIHLSNGS---SLLISKSLAPTMEVLRRLGTVLLIVGGIGVAVA
Mflv_1888|M.gilvum_PYR-GCK EHQRVLAVHLASGN---SLLLSKSLAPTGQVLKRLGTVLLIVGGIGVVVA
MMAR_4528|M.marinum_M SDQRVLAIHLPNGS---SLLISKSLKPTEAVMTKLRAVLLIVGGVGVAVA
MUL_4700|M.ulcerans_Agy99 SDQRVLAIHLPNGS---SLLISKSLKPTEAVMTKLRAVLLIVGGVGVAVA
MLBr_00175|M.leprae_Br4923 SDQRILAIHLPNDS---SLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVA
Mvan_3840|M.vanbaalenii_PYR-1 ERE------------------------RQDTLRAMLTWSFVSLGVVGVVA
MAB_2582|M.abscessus_ATCC_1997 AGLYRLVTMPTNGG--AVIVTGLPAEGVGQTLSSVFGIICVVGAAALITA
Rv2998A|M.tuberculosis_H37Rv --------------MERMRIRAAGISATDPHA----------RLPLPLAR
Mb3023c|M.bovis_AF2122/97 --------------MERMRIRAAGISATDPHA----------RLPLPLAR
MAV_3405|M.avium_104 AGATYWLVRRSLKSVDAIRARVADISASDLAE----------RVPVPDGR
MSMEG_5487|M.smegmatis_MC2_155 AIAGGAVARAGLRPVGRLTEAAERVARTDDLR----------PIPVVG-S
TH_2428|M.thermoresistible__bu AIAGGMVARAGLRPVSRLTEAAERVARTDDLR----------PIPVVG-S
Mflv_1888|M.gilvum_PYR-GCK AIAGGMVARAGLRPVARLTQAAERVARTDDLH----------PIPVVG-N
MMAR_4528|M.marinum_M AVAGGMVTRAGLRPVGRLTEAAERVARTDDLR----------PIPVFG-S
MUL_4700|M.ulcerans_Agy99 AVAGGMVTRAGLRPVGRLTEAAERVARTDDLR----------PIPVFG-S
MLBr_00175|M.leprae_Br4923 AVAGGMVTRAGLRPVGRLTEAAERVARTDDLR----------PIPVFG-S
Mvan_3840|M.vanbaalenii_PYR-1 GGFGWLMAGRALAPLQDVTATARRVADRNLHE----------RIALDGPD
MAB_2582|M.abscessus_ATCC_1997 IGAGIVIIRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTH
: : . :: : :.
Rv2998A|M.tuberculosis_H37Rv DEIRYLGTTFNDLLQRLQDAL-------ERERQFVSDAGHELRTPLAS--
Mb3023c|M.bovis_AF2122/97 DEIRYLGTTFNDLLQRLQDAL-------ERERQFVSDAGHELRTPLAS--
MAV_3405|M.avium_104 DEIAALAVTMNEMLSRLEAGH-------RAQQRFVGDASHELRSPLTTII
MSMEG_5487|M.smegmatis_MC2_155 DELARLTEAFNMMLRALAESR-------ERQARLVSDAGHELRTPLTSLR
TH_2428|M.thermoresistible__bu DELARLTEAFNMMLRALAESR-------ERQARLVADAGHELRTPLTSLR
Mflv_1888|M.gilvum_PYR-GCK DELARLTETFNMMLRALTESR-------DRQSRLVADAGHELRTPLTSLR
MMAR_4528|M.marinum_M DELARLTEAFNLMLRALAESR-------ERQARLVSDAGHELRTPLTSLR
MUL_4700|M.ulcerans_Agy99 DELARLTEAFNLMLRALAESR-------ERQARLVSDAGHELRTPLTSLR
MLBr_00175|M.leprae_Br4923 DELARLTEAFNLMLRALAESR-------ERQARLVTDAGHELRTPLTSLR
Mvan_3840|M.vanbaalenii_PYR-1 DEIKELADTFDAMLDRLDRAF-------ESQRRFVANASHELRTPLAINR
MAB_2582|M.abscessus_ATCC_1997 TELGQLGAALNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAIS
*: * ::: :* : . ::* :*.****:**:
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 SGLEVAEAHPE-----LLDAELAVN--TLLPEAHRMRALIDDLLLLARAD
MSMEG_5487|M.smegmatis_MC2_155 TNVELLMAAQEPGAPPLPEDEMAGLRADVIAQIEELSTLVGDLVDLTRED
TH_2428|M.thermoresistible__bu TNVELLMASQQPGAPGLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDD
Mflv_1888|M.gilvum_PYR-GCK TNVELLMSSMKPGAPRIPEEDMDDLRSDVIGQIEELSTLVGDLVDLTRDE
MMAR_4528|M.marinum_M TNVELLMASMEPGAPRLPEQEMVGLREDVVAQIEELSTLVGDLVDLTRGD
MUL_4700|M.ulcerans_Agy99 TNVELLMASMEPGAPRLPEQEMVGLREDVVAQIEELSTLVGDLVDLTRGD
MLBr_00175|M.leprae_Br4923 TNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDD
Mvan_3840|M.vanbaalenii_PYR-1 TLIEVALEDPE------VAESTRTLGRTLLDVNLRNERLIDGLLVLASSD
MAB_2582|M.abscessus_ATCC_1997 GYAELARRNHD-----ALPTDVAHAMSRVQSEAARMTELVEDLLLLARLD
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 ERNLLRRKELVALDDLAEAEAARVR---RDADCAVHTDIRPARLLADPAA
MSMEG_5487|M.smegmatis_MC2_155 AG--GITPEPVDMADVIDRSLERVR--RRRNDIEFDVDVIGWQVFGDAQG
TH_2428|M.thermoresistible__bu AG--GVIHEPVDIADVVDRSLERVR--RRRNDIDFDIEVVPWQVYGDAAG
Mflv_1888|M.gilvum_PYR-GCK AG--NAVHDTVEMSEVIERSLERVR--RRRNDIEFHVEITPWQVYGDAAG
MMAR_4528|M.marinum_M AG--VVVHEPVDMAEVVDRSLERVR--RRRNDIHFDVDVVGWQVYGDAAG
MUL_4700|M.ulcerans_Agy99 AG--VVVHEPVDMAEVVDRSLERVR--RRRNDIHFDVDVVGWQVYGDAAG
MLBr_00175|M.leprae_Br4923 AG--QVVHEPIDMSEVLYRSLERVR--RRRNDIHFDVQAIGWQIYGDAAG
Mvan_3840|M.vanbaalenii_PYR-1 QQ--LRHRSRVDLGEVTGRALTTVAGFARAAGIRIDSDLPQAHVHGDAAL
MAB_2582|M.abscessus_ATCC_1997 SGR-PLAQEPVDLSRLVVDAASDAHIAASEHRWLLNLPEDPVIVCGDTPR
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 MTRMIRNLVDNAVRHAVS---CVAIEVGSRDGTAVLTVGDDGPGIPPAQR
MSMEG_5487|M.smegmatis_MC2_155 LGRAVLNLLDNAAKWSPPGGRVGVRLHQVDHMHAEIVVSDQGPGIPPEER
TH_2428|M.thermoresistible__bu LSRAVMNLLDNAAKWSPSGGRVGVRLTQVDPVHAELVVSDHGPGIPPQER
Mflv_1888|M.gilvum_PYR-GCK LGRAVLNLLDNAAKWSPPGGGVWVRLRQLDQLTAEVVVSDLGPGIPPAER
MMAR_4528|M.marinum_M LSRAALNLMDNAAKWSPPGGRVGIRLRQLDPSHAELVVSDNGPGISPQER
MUL_4700|M.ulcerans_Agy99 LSRAALNLMDNAAKWSPPGGRVGIRLRQLDPSHAELVVSDNGPGISPQER
MLBr_00175|M.leprae_Br4923 LSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQER
Mvan_3840|M.vanbaalenii_PYR-1 LERLAQNLIDNALRYNVPEDGWVSVTVGTQDGFATLRVENSGPVVAAAEI
MAB_2582|M.abscessus_ATCC_1997 LHQVVANLLSNCRIHTPPGTTVTVTLRS-DGNSTYLTVADDGPGIPAGQQ
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 SRVFERFVRLDTDRARSGGGA-----GLGLAIVAEVVAAHGGTVTIGDRP
MSMEG_5487|M.smegmatis_MC2_155 RLVFERFYRSDAARAMPGS-------GLGLAIVQQVVLKHGGALRIDETV
TH_2428|M.thermoresistible__bu RLVFERFYRSTTARSMPGS-------GLGLAIVKQVVLKHGGTLRVEDTV
Mflv_1888|M.gilvum_PYR-GCK ELVFERFFRSTTARAMPGS-------GLGLAIVKQVVLKHGGSLRVEDTV
MMAR_4528|M.marinum_M RLVFERFYRSTSARAMPGS-------GLGLAIVKQVVLNHGGSLRIEDTV
MUL_4700|M.ulcerans_Agy99 RLVFERFYRSTSARAMPGS-------GLGLAIVKQVVLNHGGSLRIEDTV
MLBr_00175|M.leprae_Br4923 RLVFERFYRSTTARSLPGS-------GLGLAIVKQVVINHGGLLRVEDTA
Mvan_3840|M.vanbaalenii_PYR-1 PGLFEPFRRLAAADRVAESPAPGRGAGLGLSIVRSVAVAHGGDVRAEARP
MAB_2582|M.abscessus_ATCC_1997 NEIFERFARGDTSRSRRAG-----STGLGLAIAAAVIKAHHGEIRVN-SV
Rv2998A|M.tuberculosis_H37Rv --------------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 GGGTTLTVALPQHPAQHSSR------------------------------
MSMEG_5487|M.smegmatis_MC2_155 PGGNPPGASVHMLLPGQRIP---------------------DPGATRSAE
TH_2428|M.thermoresistible__bu PGGQPPGTSIHVVLPGRPLSGVPPASQEPQ-------PPQHAPGADPHAP
Mflv_1888|M.gilvum_PYR-GCK PGGEPPGTSVHVVLPG-------------------------RPSANLARG
MMAR_4528|M.marinum_M PGGQPPGTAICMLLPGRPMPDSAYPAAPDD--------KKTEPVDTRGAN
MUL_4700|M.ulcerans_Agy99 PGGQPPGTAICMLLPGRPMPDSAYPAAPDD--------KKTEPVDTRGAN
MLBr_00175|M.leprae_Br4923 PGVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGK
Mvan_3840|M.vanbaalenii_PYR-1 AGGLDVAVTLTACQ------------------------------------
MAB_2582|M.abscessus_ATCC_1997 AGETVFTITLPTAGTQHGAFTEKLP-------------------------
Rv2998A|M.tuberculosis_H37Rv ---------------------
Mb3023c|M.bovis_AF2122/97 ---------------------
MAV_3405|M.avium_104 ---------------------
MSMEG_5487|M.smegmatis_MC2_155 GFVDDRGGHTVATE-------
TH_2428|M.thermoresistible__bu TQTGNDAVQSVFTAENK----
Mflv_1888|M.gilvum_PYR-GCK GE-------------------
MMAR_4528|M.marinum_M GANSRGSANVISVDSQSARAR
MUL_4700|M.ulcerans_Agy99 GANSRGSANVISVDSQSARAR
MLBr_00175|M.leprae_Br4923 SANFRDSAHVISVDYQSARAR
Mvan_3840|M.vanbaalenii_PYR-1 ---------------------
MAB_2582|M.abscessus_ATCC_1997 ---------------------