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MTPRSPARRSTIRWRLTVLYGSAFFIAGAVLICLMYVFLQQSLHNRPAGAQGVVSQFLDDRGVRNRPVVE GLLRAVATESERERQDTLRAMLTWSFVSLGVVGVVAGGFGWLMAGRALAPLQDVTATARRVADRNLHERI ALDGPDDEIKELADTFDAMLDRLDRAFESQRRFVANASHELRTPLAINRTLIEVALEDPEVAESTRTLGR TLLDVNLRNERLIDGLLVLASSDQQLRHRSRVDLGEVTGRALTTVAGFARAAGIRIDSDLPQAHVHGDAA LLERLAQNLIDNALRYNVPEDGWVSVTVGTQDGFATLRVENSGPVVAAAEIPGLFEPFRRLAAADRVAES PAPGRGAGLGLSIVRSVAVAHGGDVRAEARPAGGLDVAVTLTACQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3840 | - | - | 100% (395) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_4843 | - | 2e-26 | 34.35% (294) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5174 | - | 4e-26 | 31.96% (341) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1008 | mprB | 4e-26 | 33.22% (304) | two component sensor kinase MprB |
| M. gilvum PYR-GCK | Mflv_1582 | - | 2e-27 | 31.55% (355) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0982 | mprB | 7e-26 | 33.22% (304) | two component sensor kinase MprB |
| M. leprae Br4923 | MLBr_00175 | - | 2e-24 | 31.27% (307) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_1077 | - | 4e-27 | 33.33% (309) | two component sensor kinase MprB |
| M. marinum M | MMAR_4941 | phoR | 2e-29 | 32.65% (340) | two-component system response phosphate sensor kinase, PhoR |
| M. avium 104 | MAV_3405 | - | 3e-38 | 37.54% (293) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_5870 | - | 9e-28 | 33.04% (339) | sensor histidine kinase PhoR |
| M. thermoresistible (build 8) | TH_4550 | - | 7e-71 | 41.18% (391) | PUTATIVE putative integral membrane sensor signal transduction |
| M. ulcerans Agy99 | MUL_0464 | phoR | 1e-29 | 32.65% (340) | two component system response phosphate sensor kinase, PhoR |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3840|M.vanbaalenii_PYR-1 -----------------------MTPRSPARRSTIRWRLTVLYGSAFFIA
TH_4550|M.thermoresistible__bu --------------------------------VSLRGRITIMSAAVSCAA
Mflv_1582|M.gilvum_PYR-GCK MSSASPDERSNLNNGDVAGRRRYLRRGVPLRVALVAATLLLVACGLLASG
MSMEG_5870|M.smegmatis_MC2_155 -----------MNRG---------RRGIPLRVGLVAAALVLVACGLLASG
MMAR_4941|M.marinum_M -----------MAER--------LPRAVPLRVGLVAATLALVLCGLLASG
MUL_0464|M.ulcerans_Agy99 -----------MAER--------LPRAVQLRVGLVAATLALVLCGLLASG
MAV_3405|M.avium_104 --MFSGGPRACRIEG----------VHLGISARSAAVAAIVVFCALTVAG
Mb1008|M.bovis_AF2122/97 --MWWFRRRDR-------APLRATSS-LSLRWRVMLLAMSMVAMVVVLMS
Rv0982|M.tuberculosis_H37Rv --MWWFRRRDR-------APLRATSS-LSLRWRVMLLAMSMVAMVVVLMS
MLBr_00175|M.leprae_Br4923 --MVRFAWRRR-------ASLRATSS-LSLRWRVMLLAMSMVAMVVVLMA
MAB_1077|M.abscessus_ATCC_1997 MSTLRMPRRMRDSSTAIFTPLRATSSSVSLRWRVMLLAMSMVAMVVVLMA
:: .
Mvan_3840|M.vanbaalenii_PYR-1 GAVLICLMYVFLQ----------------------------------QSL
TH_4550|M.thermoresistible__bu AALLLAITYALVD----------------------------------LQL
Mflv_1582|M.gilvum_PYR-GCK IAVTTIMQHSLMNRVDDTLLDASRGWAQVPRRLPTITVDDPNPARPPSDF
MSMEG_5870|M.smegmatis_MC2_155 IAVTSIMRHTEVSRIDQTLLDASRSWAQAPRRAPTTPLEGPNPARPPSNF
MMAR_4941|M.marinum_M VAVTSILRHSLVSRIDSTLLEASRTWAQASWRHSMPSVEGPDPARPPSKF
MUL_0464|M.ulcerans_Agy99 VAVTSILRHSLVSRIDSTLLEASRTWAQASWRHSMPSVEGPDPARPPSKF
MAV_3405|M.avium_104 AGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNALLTTDQRVV
Mb1008|M.bovis_AF2122/97 FAVYAVISAALYSDIDNQLQSRAQLLIASG-SLAADPGKAIEGTAYS-DV
Rv0982|M.tuberculosis_H37Rv FAVYAVISAALYSDIDNQLQSRAQLLIASG-SLAADPGKAIEGTAYS-DV
MLBr_00175|M.leprae_Br4923 FAVYVVISAALYSDIDNQLQSRAQLLIASG-SLAADPGKAIEGTAYS-DV
MAB_1077|M.abscessus_ATCC_1997 VASYLLVSTALYRDVDKQLNDRANLLIGSG-LLSVDPRRAIEGTAYSADV
. : .
Mvan_3840|M.vanbaalenii_PYR-1 HNRPAGAQGVVSQFLDDRGVR-NRPVVE----------------------
TH_4550|M.thermoresistible__bu SRR--GPVVMRRSPPDTAPAEPTGPEVS----------------------
Mflv_1582|M.gilvum_PYR-GCK YVRGIDPDGHVWMLINDREAEPELPADNNVGPEPRTVG--SVDHSDVQWR
MSMEG_5870|M.smegmatis_MC2_155 YVRGFDEDGRTWIAVNDREAEPALPENNDVGPVPVTVG--SIDKSNVEWR
MMAR_4941|M.marinum_M YVRSISPDGRAMTAINDRNAEPALPADNDVGSDPTTLP--SVNGSNIEWR
MUL_0464|M.ulcerans_Agy99 YVRSISPDGRAMTAINDRNAEPALPADNDVGSDPTTLP--SVNGSNIEWR
MAV_3405|M.avium_104 ATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRVS
Mb1008|M.bovis_AF2122/97 NAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMS-----RRTTADQ
Rv0982|M.tuberculosis_H37Rv NAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMS-----RRTTADQ
MLBr_00175|M.leprae_Br4923 NAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMS-----QRTASDQ
MAB_1077|M.abscessus_ATCC_1997 NAKLIFPGLITFSATQQGQTIPYGTPEQAVTRGDLQQS-----LRTVNHQ
. . .
Mvan_3840|M.vanbaalenii_PYR-1 --------GLLRAVATESERERQDTLRAMLTWSFVSLGVVGVVAGGFGWL
TH_4550|M.thermoresistible__bu --------GVAAWMDRHRAELQEAATNSLLLYGAVAMAAVTALAAVVAWL
Mflv_1582|M.gilvum_PYR-GCK AMTVRGLRGELTTVAIDLS-DVKSTMRSLVYTQVGIGAAVLLVLGIAGYA
MSMEG_5870|M.smegmatis_MC2_155 AMTVRGPNGELTTVAIDLS-EVQSSVRALVWSQVGIGAAVLLVLGVVGYV
MMAR_4941|M.marinum_M AVSVHGPQGGLTTVAIDLS-DVQHTVRSLVWLQIGIGAGVLVVVGLAGFA
MUL_0464|M.ulcerans_Agy99 AVSVHGPQGGLTTVAIDLS-DVQHTVRSLVWLQIGIGAGVLVVVGLAGFA
MAV_3405|M.avium_104 GQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVAVAAGATYW
Mb1008|M.bovis_AF2122/97 RVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVAGGM
Rv0982|M.tuberculosis_H37Rv RVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVAGGM
MLBr_00175|M.leprae_Br4923 RILAIHLPNDSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGGM
MAB_1077|M.abscessus_ATCC_1997 RVLALRLDNGSTLIMAKSLDPTDTVLRRLGWVLLIVGGVGVAVAAAAGAM
. : . : : .
Mvan_3840|M.vanbaalenii_PYR-1 MAGRALAPLQDVTATARRVADR-----NLHERIALDGPDDEIKELADTFD
TH_4550|M.thermoresistible__bu VAGRVLSPLHRVTATARRISRAPALSSGLRERIQLAGPADEVKDLADTFD
Mflv_1582|M.gilvum_PYR-GCK VVHRSLRPLSEVEQTAAAIAAG-----QLDRRVPERDPRTEVGRLSLALN
MSMEG_5870|M.smegmatis_MC2_155 VVHRSLRPLVEVERTAAAIAAG-----QLDRRVPERDPRTEVGRLSSALN
MMAR_4941|M.marinum_M VVQRSLRPLSEVEQTAAAIASG-----QLDRRVPERDPRTEVGQLSLAMN
MUL_0464|M.ulcerans_Agy99 VVQRSLRPLSEVEQTAAAIASG-----QLDRRVPERDPRTEVGQLSLAMN
MAV_3405|M.avium_104 LVRRSLKSVDAIRARVADISAS-----DLAERVPVPDGRDEIAALAVTMN
Mb1008|M.bovis_AF2122/97 VTRAGLRPVGRLTEAAERVART-----DDLRPIPVFGS-DELARLTEAFN
Rv0982|M.tuberculosis_H37Rv VTRAGLRPVGRLTEAAERVART-----DDLRPIPVFGS-DELARLTEAFN
MLBr_00175|M.leprae_Br4923 VTRAGLRPVGRLTEAAERVART-----DDLRPIPVFGS-DELARLTEAFN
MAB_1077|M.abscessus_ATCC_1997 VAGTGLRPVARLTDAAERVART-----DDLRPIAVTGS-DELARLTISFN
:. * .: : . :: . : . *: *: :::
Mvan_3840|M.vanbaalenii_PYR-1 AMLDRLDRAFESQR--------------RFVANASHELRTPLAINRTLIE
TH_4550|M.thermoresistible__bu QMLCRLDRAFAGQR--------------RFVGDASHELRTPVAVSRAMIE
Mflv_1582|M.gilvum_PYR-GCK GMLAQIQHAMALSESSAEKARSSEDRMRRFITDASHELRTPLTTIR-GFA
MSMEG_5870|M.smegmatis_MC2_155 GMLAQIQRAVAASEASAEQARSSEDRMRRFITDASHELRTPLTTIR-GFA
MMAR_4941|M.marinum_M GMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIR-GFA
MUL_0464|M.ulcerans_Agy99 GMLSQIQVALAASEDSAEKARSSEERMRRFITDASHELRTPLTTIR-GFA
MAV_3405|M.avium_104 EMLSRLEAGHRAQQ--------------RFVGDASHELRSPLTTIISGLE
Mb1008|M.bovis_AF2122/97 LMLRALAESRERQA--------------RLVTDAGHELRTPLTSLRTNVE
Rv0982|M.tuberculosis_H37Rv LMLRALAESRERQA--------------RLVTDAGHELRTPLTSLRTNVE
MLBr_00175|M.leprae_Br4923 LMLRALAESRERQA--------------RLVTDAGHELRTPLTSLRTNVE
MAB_1077|M.abscessus_ATCC_1997 TMLRALAESRDRQA--------------RLVTDAGHELRTPLTSLRTNTE
** : . . *:: :*.****:*::
Mvan_3840|M.vanbaalenii_PYR-1 VALE-DPEVAE-----STRTLGRTLLDVNLRNERLIDGLLVLASSDQQ--
TH_4550|M.thermoresistible__bu LAMRRNPGSPE-----LIR-LGTDLLEVNERLERLITGLLALTNAENG--
Mflv_1582|M.gilvum_PYR-GCK ELYR--QGAAR-----DVEMLMGRIKSESRRMGLLVEDLLLLARLDAQRP
MSMEG_5870|M.smegmatis_MC2_155 ELYR--QGAAR-----DIEMLMGRIESESRRMGLLVEDLLLLARLDAQRP
MMAR_4941|M.marinum_M ELYR--QGAAR-----DVAMLLSRIESEASRMGLLVDDLLTLARLDVQRP
MUL_0464|M.ulcerans_Agy99 ELYR--QGAAR-----DVAMLLSRIESEASRMGLLVDDLLTLARLDVQRP
MAV_3405|M.avium_104 VAEA--HPELL-----DAELAVNTLLPEAHRMRALIDDLLLLARADERNL
Mb1008|M.bovis_AF2122/97 LLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAG--
Rv0982|M.tuberculosis_H37Rv LLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAG--
MLBr_00175|M.leprae_Br4923 LLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAG--
MAB_1077|M.abscessus_ATCC_1997 LLMAAMQPGAPRLPDEEMQALQQDVIAQIEELSTLVGDLVDLARGDGA--
: . *: .*: *: :
Mvan_3840|M.vanbaalenii_PYR-1 -LRHRSRVDLGEVTGRALTTVAGFARAAGIRIDSDLPQAHVHGDAALLER
TH_4550|M.thermoresistible__bu -VIDAHTVDLADVAGHAAAQLAGTARARSVEVDTTLSEAVTRGDATLLER
Mflv_1582|M.gilvum_PYR-GCK LEHRRVDLLALASDTVHDAQSIAPKRRIRMEVFDGPGTPEVLGDEARLRQ
MSMEG_5870|M.smegmatis_MC2_155 LERRRVDLLALATDAVHDAQSIAPKRRVKMEVFDGPGTPEVLGDEARLRQ
MMAR_4941|M.marinum_M LERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQ
MUL_0464|M.ulcerans_Agy99 LERNRVDLLVLAADAVHDARAIDRKRAITVEVLEGPGTPEVLGDEPRLRQ
MAV_3405|M.avium_104 LRRK----ELVALDDLAEAEAARVRRDADCAVHTDIRPARLLADPAAMTR
Mb1008|M.bovis_AF2122/97 ---EVVHEPVDMADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSR
Rv0982|M.tuberculosis_H37Rv ---EVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSR
MLBr_00175|M.leprae_Br4923 ---QVVHEPIDMSEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSR
MAB_1077|M.abscessus_ATCC_1997 ---DIVHEPVDMVEVVEGTLERVRRRRNDIEFDVVMQPWQVYGDAAGLSR
: * . .* . : :
Mvan_3840|M.vanbaalenii_PYR-1 LAQNLIDNALRYNVPEDGWVSVTVG-TQDGFATLRVENSGPVVAAAEIPG
TH_4550|M.thermoresistible__bu LAHNLIENAVKYSGDDSPRVVVTTGSLSDSQVFLRVSNNGEPIRDEDLPT
Mflv_1582|M.gilvum_PYR-GCK VLSNLVANALQH-TPESAGVTVRVG-TADDTAIVEVCDEGPGMTGEDAQR
MSMEG_5870|M.smegmatis_MC2_155 VIGNLVANAVQH-TPETAGITVRVG-TDGDNAVLEVCDEGPGMSQEDARR
MMAR_4941|M.marinum_M VLSNLVGNALQH-TPDSADVTVRVG-TAGQNAVLEVADKGPGMPAEDAAR
MUL_0464|M.ulcerans_Agy99 VLSNLVGNALQH-TPDSADVTVRVG-TAGENAVLEVADKGPGMPAEDAAR
MAV_3405|M.avium_104 MIRNLVDNAVRH-AVS--CVAIEVG-SRDGTAVLTVGDDGPGIPPAQRSR
Mb1008|M.bovis_AF2122/97 MALNLMDNAAKW-SPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRL
Rv0982|M.tuberculosis_H37Rv MALNLMDNAAKW-SPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRL
MLBr_00175|M.leprae_Br4923 AVLNLMDNAAKW-SPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRL
MAB_1077|M.abscessus_ATCC_1997 AVLNLLDNAAKW-SPSGTAVSVRLAQVDAAHAELVISDHGPGIPPAERDL
**: ** : : : . : : : * : :
Mvan_3840|M.vanbaalenii_PYR-1 LFEPFRRLAAADRVAESPAPGRGAGLGLSIVRSVAVAHGGDVRAEARPA-
TH_4550|M.thermoresistible__bu LFEPFRRLTRDTRAS-------GAGLGLSIAAAIVQAHQGTIEATARPD-
Mflv_1582|M.gilvum_PYR-GCK VFERFYRADSSRARA-----SGGTGLGLSIVDSLVYAHGGRVSVTTAPG-
MSMEG_5870|M.smegmatis_MC2_155 VFERFYRADTSRTRA-----SGGTGLGLSIVDSLVYAHGGTVKVTTALG-
MMAR_4941|M.marinum_M VFERFYRTDSSRARA-----SGGTGLGLSIVHSLVKAHGGDVTLTTAPG-
MUL_0464|M.ulcerans_Agy99 VFERFYRTDSSRARA-----SGGTGLGLSIVHSLVKAHGGDVTLTTAPG-
MAV_3405|M.avium_104 VFERFVRLDTDRARS-----GGGAGLGLAIVAEVVAAHGGTVTIGDRPG-
Mb1008|M.bovis_AF2122/97 VFERFYRSASARALP-------GSGLGLAIVKQVVLNHGGLLRIEDTDP-
Rv0982|M.tuberculosis_H37Rv VFERFYRSASARALP-------GSGLGLAIVKQVVLNHGGLLRIEDTDP-
MLBr_00175|M.leprae_Br4923 VFERFYRSTTARSLP-------GSGLGLAIVKQVVINHGGLLRVEDTAP-
MAB_1077|M.abscessus_ATCC_1997 VFERFYRATPARGMP-------GSGLGLAIVKQVVLKHGGAIKVEETDPG
:** * * . *:****:*. :. * * :
Mvan_3840|M.vanbaalenii_PYR-1 --------GGLDVAVTLTACQ-----------------------------
TH_4550|M.thermoresistible__bu --------GGLTVEVVLPAPAAARP-------------------------
Mflv_1582|M.gilvum_PYR-GCK --------CGCRFTVRLPRVTDERLREEQATDERLREEQMPAP-------
MSMEG_5870|M.smegmatis_MC2_155 --------KGSRFTVSLPRIADLPARL-----------------------
MMAR_4941|M.marinum_M --------EGCCFRVTLPRVSEAAVELTEPVS------------------
MUL_0464|M.ulcerans_Agy99 --------EGCCFRVTLPRVSEAAVELTEPVS------------------
MAV_3405|M.avium_104 --------GGTTLTVALPQHPAQHSSR-----------------------
Mb1008|M.bovis_AF2122/97 ----GGQPPGTSIYVLLPGRRMPIP---QLPGATAGAR------------
Rv0982|M.tuberculosis_H37Rv ----GGQPPGTSIYVLLPGRRMPIP---QLPGATAGAR------------
MLBr_00175|M.leprae_Br4923 ----GVQPPGTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQV
MAB_1077|M.abscessus_ATCC_1997 AVIDGEPAPGTSMHVLLPGRPGPIVR--PNMGDTAGRR------------
* . * *.
Mvan_3840|M.vanbaalenii_PYR-1 ----------------------------
TH_4550|M.thermoresistible__bu ----------------------------
Mflv_1582|M.gilvum_PYR-GCK EHAGEESRGEQTDVPVSATAPTPP----
MSMEG_5870|M.smegmatis_MC2_155 ----------------------------
MMAR_4941|M.marinum_M ----------------------------
MUL_0464|M.ulcerans_Agy99 ----------------------------
MAV_3405|M.avium_104 ----------------------------
Mb1008|M.bovis_AF2122/97 STDIENSRGSANVISVESQSTRAT----
Rv0982|M.tuberculosis_H37Rv STDIENSRGSANVISVESQSTRAT----
MLBr_00175|M.leprae_Br4923 SGKSANFRDSAHVISVDYQSARAR----
MAB_1077|M.abscessus_ATCC_1997 -----NSGPNAREISVDSQSVPAAWRPS