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VERMRIRAAGISATDPHARLPLPLARDEIRYLGTTFNDLLQRLQDALERERQFVSDAGHELRTPLAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3023c | - | - | 100% (67) | hypothetical protein Mb3023c |
| M. bovis AF2122 / 97 | Mb0617c | - | 2e-13 | 53.62% (69) | two component sensor kinase |
| M. bovis AF2122 / 97 | Mb1008 | mprB | 1e-07 | 40.30% (67) | two component sensor kinase MprB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1888 | - | 4e-08 | 40.30% (67) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0601c | - | 2e-13 | 53.62% (69) | two component sensor kinase |
| M. leprae Br4923 | MLBr_00175 | - | 4e-08 | 40.30% (67) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_2582 | - | 8e-07 | 51.06% (47) | putative two component sensor kinase |
| M. marinum M | MMAR_4528 | mprB | 7e-08 | 41.79% (67) | two-component sensor kinase MprB |
| M. avium 104 | MAV_3405 | - | 4e-12 | 46.27% (67) | hypothetical protein MAV_3405 |
| M. smegmatis MC2 155 | MSMEG_5487 | - | 4e-08 | 41.79% (67) | sensor histidine kinase |
| M. thermoresistible (build 8) | TH_2428 | - | 4e-08 | 40.30% (67) | PUTATIVE integral membrane sensor signal transduction histidine |
| M. ulcerans Agy99 | MUL_4700 | mprB | 5e-08 | 41.79% (67) | two component sensor kinase MprB |
| M. vanbaalenii PYR-1 | Mvan_3840 | - | 8e-09 | 52.00% (50) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5487|M.smegmatis_MC2_155 MASATCCGKRLRSEMAFPPNS-WRPTGPLPTSSLSLRWRVMMLAMSMVAL
TH_2428|M.thermoresistible__bu ----------MTFAQPYPPSPPQRQATSQPASSLSLRWRVMLLAMSMVAM
Mflv_1888|M.gilvum_PYR-GCK MAGD-------PNTATWPPQP--PGPPPPPASSISLRWRVMLLAMSMAVI
MMAR_4528|M.marinum_M -------------MVGFRRGP---RAPLRATSSLSLRWRVMLLAMSMVAM
MUL_4700|M.ulcerans_Agy99 -------------MVGFRRGP---RAPLRATSSLSLRWRVMLLAMSMVAM
MLBr_00175|M.leprae_Br4923 -------------MVRFAWRR---RASLRATSSLSLRWRVMLLAMSMVAM
Mvan_3840|M.vanbaalenii_PYR-1 ------------------------MTPRSPARRSTIRWRLTVLYGSAFFI
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 -------------MFSGGPRACRIEGVHLGISARSAAVAAIVVFCALTVA
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------MALVLA
MAB_2582|M.abscessus_ATCC_1997 -----------------------------MNRFLNTQLDEQVRDAGNRSV
MSMEG_5487|M.smegmatis_MC2_155 VVVLMAVAVYAVVSRALYDDLDNQLHSRARLLIESGSLAADPGKAIEGTA
TH_2428|M.thermoresistible__bu VVVLMSIALYAVVSRALYNDIDNQLHSRARLLIESGSLAADPGRAIEGTA
Mflv_1888|M.gilvum_PYR-GCK PVVLMGVAGYAVVSRALYDDIDDQLRTRAQMLIESGSLDADPGKAIEGTA
MMAR_4528|M.marinum_M VVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTA
MUL_4700|M.ulcerans_Agy99 VVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTA
MLBr_00175|M.leprae_Br4923 VVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTA
Mvan_3840|M.vanbaalenii_PYR-1 AGAVLICLMYVFLQQSLHNRPAGAQGVVSQFLDDRG--------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 GAGLDAILYRSLLSGVDYAAAERVRDIAKALQSDSREELDNALLTTDQRV
Rv0601c|M.tuberculosis_H37Rv AAG----------------------AVTVVQFRDAAHEAD----------
MAB_2582|M.abscessus_ATCC_1997 VLFELGPPPPLSLPRPLANGWRPTDGPGPAFLDAPGQSIGMVG-------
MSMEG_5487|M.smegmatis_MC2_155 YSDVNAMLVIPGRSIYTANQQGQTLPLGEPEKDVISG--ELLMSLRTANH
TH_2428|M.thermoresistible__bu YSDVNAMLVNPGRSIYTANQQGEALPLGEPERQVLSG--ELVMSLRTADQ
Mflv_1888|M.gilvum_PYR-GCK YSDMNAMFYIPGRSKYTAKQQGQTLPVGRPEQDVMDG--TLWMSLRTVEH
MMAR_4528|M.marinum_M YSDVNAMLVNPGRSIYTANQPGQTLPVGAPEKAVIHG--DLFLSRRTVSD
MUL_4700|M.ulcerans_Agy99 YSDVNAMLVNPGRSIYTANQPGQTLPVGAPEKAVIHG--DLFLSRRTVSD
MLBr_00175|M.leprae_Br4923 YSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRG--ELFMSQRTASD
Mvan_3840|M.vanbaalenii_PYR-1 ----------------------------VRNRPVVEG--LLRAVATESER
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 VATQLIGPDGSVVKRSGSAPATPLVPTADFDFTLRRGLPDDAVSGDDMRV
Rv0601c|M.tuberculosis_H37Rv -------PDG-----------------------ALRGLTDDITAD-----
MAB_2582|M.abscessus_ATCC_1997 -AVAVNGHVTEAARITADGSRERLSPQACREVEGLLQQSTSTVDLDHAGL
MSMEG_5487|M.smegmatis_MC2_155 QRVLAVHLANGSSLLISKSLAPTVQVLRRLGTVLLIVGGIGVAVAAIAGG
TH_2428|M.thermoresistible__bu QRVLAIHLSNGSSLLISKSLAPTMEVLRRLGTVLLIVGGIGVAVAAIAGG
Mflv_1888|M.gilvum_PYR-GCK QRVLAVHLASGNSLLLSKSLAPTGQVLKRLGTVLLIVGGIGVVVAAIAGG
MMAR_4528|M.marinum_M QRVLAIHLPNGSSLLISKSLKPTEAVMTKLRAVLLIVGGVGVAVAAVAGG
MUL_4700|M.ulcerans_Agy99 QRVLAIHLPNGSSLLISKSLKPTEAVMTKLRAVLLIVGGVGVAVAAVAGG
MLBr_00175|M.leprae_Br4923 QRILAIHLPNDSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVAGG
Mvan_3840|M.vanbaalenii_PYR-1 E---------------------RQDTLRAMLTWSFVSLGVVGVVAGGFGW
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 SGQKVATRSGVYTVLVGGGSEAVEATARTLAILLATTAPVIVAVAAGATY
Rv0601c|M.tuberculosis_H37Rv -----------------------------LVRELVTILPIVLVIAAVAAY
MAB_2582|M.abscessus_ATCC_1997 YRLVTMPTNGGAVIVTGLPAEGVGQTLSSVFGIICVVGAAALITAIGAGI
MSMEG_5487|M.smegmatis_MC2_155 AVARAGLRPVGRLTEAAERVART----------DDLRPIPVVG-SDELAR
TH_2428|M.thermoresistible__bu MVARAGLRPVSRLTEAAERVART----------DDLRPIPVVG-SDELAR
Mflv_1888|M.gilvum_PYR-GCK MVARAGLRPVARLTQAAERVART----------DDLHPIPVVG-NDELAR
MMAR_4528|M.marinum_M MVTRAGLRPVGRLTEAAERVART----------DDLRPIPVFG-SDELAR
MUL_4700|M.ulcerans_Agy99 MVTRAGLRPVGRLTEAAERVART----------DDLRPIPVFG-SDELAR
MLBr_00175|M.leprae_Br4923 MVTRAGLRPVGRLTEAAERVART----------DDLRPIPVFG-SDELAR
Mvan_3840|M.vanbaalenii_PYR-1 LMAGRALAPLQDVTATARRVADR----------NLHERIALDGPDDEIKE
Mb3023c|M.bovis_AF2122/97 ---------MERMRIRAAGISAT----------DPHARLPLPLARDEIRY
MAV_3405|M.avium_104 WLVRRSLKSVDAIRARVADISAS----------DLAERVPVPDGRDEIAA
Rv0601c|M.tuberculosis_H37Rv LLSRAALRPVDRIRAAAQTLTTTPHP-------DTDAPLPVPPTDDEIAW
MAB_2582|M.abscessus_ATCC_1997 VIIRRQLDPLSQVATAAQEVAELELHRGEVNLPTPIIDVASNRTHTELGQ
: : . :: :. *:
MSMEG_5487|M.smegmatis_MC2_155 LTEAFNMMLRALAESR-------ERQARLVSDAGHELRTPLTSLRTNVEL
TH_2428|M.thermoresistible__bu LTEAFNMMLRALAESR-------ERQARLVADAGHELRTPLTSLRTNVEL
Mflv_1888|M.gilvum_PYR-GCK LTETFNMMLRALTESR-------DRQSRLVADAGHELRTPLTSLRTNVEL
MMAR_4528|M.marinum_M LTEAFNLMLRALAESR-------ERQARLVSDAGHELRTPLTSLRTNVEL
MUL_4700|M.ulcerans_Agy99 LTEAFNLMLRALAESR-------ERQARLVSDAGHELRTPLTSLRTNVEL
MLBr_00175|M.leprae_Br4923 LTEAFNLMLRALAESR-------ERQARLVTDAGHELRTPLTSLRTNVEL
Mvan_3840|M.vanbaalenii_PYR-1 LADTFDAMLDRLDRAF-------ESQRRFVANASHELRTPLAINRTLIEV
Mb3023c|M.bovis_AF2122/97 LGTTFNDLLQRLQDAL-------ERERQFVSDAGHELRTPLAS-------
MAV_3405|M.avium_104 LAVTMNEMLSRLEAGH-------RAQQRFVGDASHELRSPLTTIISGLEV
Rv0601c|M.tuberculosis_H37Rv LATTLNTMLTRLQRAL-------AHEQQFVADASHELRTPLALLTTELEL
MAB_2582|M.abscessus_ATCC_1997 LGAALNRMLERIDDALSARHVSETRVRQFVADASHELRTPLAAISGYAEL
* ::: :* : . ::* :*.****:**:
MSMEG_5487|M.smegmatis_MC2_155 LMAAQEPGAPPLPEDEMAGLRADVIAQIEELSTLVGDLVDLTREDAG-GI
TH_2428|M.thermoresistible__bu LMASQQPGAPGLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDDAG-GV
Mflv_1888|M.gilvum_PYR-GCK LMSSMKPGAPRIPEEDMDDLRSDVIGQIEELSTLVGDLVDLTRDEAG-NA
MMAR_4528|M.marinum_M LMASMEPGAPRLPEQEMVGLREDVVAQIEELSTLVGDLVDLTRGDAG-VV
MUL_4700|M.ulcerans_Agy99 LMASMEPGAPRLPEQEMVGLREDVVAQIEELSTLVGDLVDLTRGDAG-VV
MLBr_00175|M.leprae_Br4923 LIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAG-QV
Mvan_3840|M.vanbaalenii_PYR-1 ALEDPE------VAESTRTLGRTLLDVNLRNERLIDGLLVLASSDQQ-LR
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 AEAHPELLDAELAVNTLLPEAHRMRALIDDLL-----LLARADERNL-LR
Rv0601c|M.tuberculosis_H37Rv RCAGPDPPTS----------------------------------------
MAB_2582|M.abscessus_ATCC_1997 ARRNHDALPTDVAHAMSR-----VQSEAARMTELVEDLLLLARLDSGRPL
MSMEG_5487|M.smegmatis_MC2_155 TPEPVDMADVIDRSLERVR--RRRNDIEFDVDVIGWQVFGDAQGLGRAVL
TH_2428|M.thermoresistible__bu IHEPVDIADVVDRSLERVR--RRRNDIDFDIEVVPWQVYGDAAGLSRAVM
Mflv_1888|M.gilvum_PYR-GCK VHDTVEMSEVIERSLERVR--RRRNDIEFHVEITPWQVYGDAAGLGRAVL
MMAR_4528|M.marinum_M VHEPVDMAEVVDRSLERVR--RRRNDIHFDVDVVGWQVYGDAAGLSRAAL
MUL_4700|M.ulcerans_Agy99 VHEPVDMAEVVDRSLERVR--RRRNDIHFDVDVVGWQVYGDAAGLSRAAL
MLBr_00175|M.leprae_Br4923 VHEPIDMSEVLYRSLERVR--RRRNDIHFDVQAIGWQIYGDAAGLSRAVL
Mvan_3840|M.vanbaalenii_PYR-1 HRSRVDLGEVTGRALTTVAGFARAAGIRIDSDLPQAHVHGDAALLERLAQ
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 RKELVALDDLAEAEAARVR---RDADCAVHTDIRPARLLADPAAMTRMIR
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2582|M.abscessus_ATCC_1997 AQEPVDLSRLVVDAASDAHIAASEHRWLLNLPEDPVIVCGDTPRLHQVVA
MSMEG_5487|M.smegmatis_MC2_155 NLLDNAAKWSPPGGRVGVRLHQVDHMHAEIVVSDQGPGIPPEERRLVFER
TH_2428|M.thermoresistible__bu NLLDNAAKWSPSGGRVGVRLTQVDPVHAELVVSDHGPGIPPQERRLVFER
Mflv_1888|M.gilvum_PYR-GCK NLLDNAAKWSPPGGGVWVRLRQLDQLTAEVVVSDLGPGIPPAERELVFER
MMAR_4528|M.marinum_M NLMDNAAKWSPPGGRVGIRLRQLDPSHAELVVSDNGPGISPQERRLVFER
MUL_4700|M.ulcerans_Agy99 NLMDNAAKWSPPGGRVGIRLRQLDPSHAELVVSDNGPGISPQERRLVFER
MLBr_00175|M.leprae_Br4923 NLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFER
Mvan_3840|M.vanbaalenii_PYR-1 NLIDNALRYNVPEDGWVSVTVGTQDGFATLRVENSGPVVAAAEIPGLFEP
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 NLVDNAVRHAVS---CVAIEVGSRDGTAVLTVGDDGPGIPPAQRSRVFER
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2582|M.abscessus_ATCC_1997 NLLSNCRIHTPPGTTVTVTLRS-DGNSTYLTVADDGPGIPAGQQNEIFER
MSMEG_5487|M.smegmatis_MC2_155 FYRSDAARAMPGS-------GLGLAIVQQVVLKHGGALRIDETVPGGNPP
TH_2428|M.thermoresistible__bu FYRSTTARSMPGS-------GLGLAIVKQVVLKHGGTLRVEDTVPGGQPP
Mflv_1888|M.gilvum_PYR-GCK FFRSTTARAMPGS-------GLGLAIVKQVVLKHGGSLRVEDTVPGGEPP
MMAR_4528|M.marinum_M FYRSTSARAMPGS-------GLGLAIVKQVVLNHGGSLRIEDTVPGGQPP
MUL_4700|M.ulcerans_Agy99 FYRSTSARAMPGS-------GLGLAIVKQVVLNHGGSLRIEDTVPGGQPP
MLBr_00175|M.leprae_Br4923 FYRSTTARSLPGS-------GLGLAIVKQVVINHGGLLRVEDTAPGVQPP
Mvan_3840|M.vanbaalenii_PYR-1 FRRLAAADRVAESPAPGRGAGLGLSIVRSVAVAHGGDVRAEARPAGGLDV
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 FVRLDTDRARSGGGA-----GLGLAIVAEVVAAHGGTVTIGDRPGGGTTL
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2582|M.abscessus_ATCC_1997 FARGDTSRSRRAG-----STGLGLAIAAAVIKAHHGEIRVN-SVAGETVF
MSMEG_5487|M.smegmatis_MC2_155 GASVHMLLPGQRIP---------------------DPGATRSAEGFVDDR
TH_2428|M.thermoresistible__bu GTSIHVVLPGRPLSGVPPASQEPQ-------PPQHAPGADPHAPTQTGND
Mflv_1888|M.gilvum_PYR-GCK GTSVHVVLPG-------------------------RPSANLARGGE----
MMAR_4528|M.marinum_M GTAICMLLPGRPMPDSAYPAAPDD--------KKTEPVDTRGANGANSRG
MUL_4700|M.ulcerans_Agy99 GTAICMLLPGRPMPDSAYPAAPDD--------KKTEPVDTRGANGANSRG
MLBr_00175|M.leprae_Br4923 GTSIYVLLPGRPMPVSAYSTLADQDMGEANFQDKIGPAVQVSGKSANFRD
Mvan_3840|M.vanbaalenii_PYR-1 AVTLTACQ------------------------------------------
Mb3023c|M.bovis_AF2122/97 --------------------------------------------------
MAV_3405|M.avium_104 TVALPQHPAQHSSR------------------------------------
Rv0601c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2582|M.abscessus_ATCC_1997 TITLPTAGTQHGAFTEKLP-------------------------------
MSMEG_5487|M.smegmatis_MC2_155 GGHTVATE-------
TH_2428|M.thermoresistible__bu AVQSVFTAENK----
Mflv_1888|M.gilvum_PYR-GCK ---------------
MMAR_4528|M.marinum_M SANVISVDSQSARAR
MUL_4700|M.ulcerans_Agy99 SANVISVDSQSARAR
MLBr_00175|M.leprae_Br4923 SAHVISVDYQSARAR
Mvan_3840|M.vanbaalenii_PYR-1 ---------------
Mb3023c|M.bovis_AF2122/97 ---------------
MAV_3405|M.avium_104 ---------------
Rv0601c|M.tuberculosis_H37Rv ---------------
MAB_2582|M.abscessus_ATCC_1997 ---------------