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MPEPTPTAYPVRLDELINAIKRVHSDVLDQLSDAVLAAEHLGEIADHLIGHFVDQARRSGASWSDIGKSM GVTKQAAQKRFVPRAEATTLDSNQGFRRFTPRARNAVVAAQNAAHGAASSEITPDHLLLGVLTDPAALAT ALLQQQEIDIATLRTAVTLPPAVTEPPQPIPFSGPARKVLELTFREALRLGHNYIGTEHLLLALLELEDG DGPLHRSGVDKSRAEADLITTLASLTGANAAGATDAGATDAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2667 | clpC2 | - | 100% (252) | POSSIBLE ATP-DEPENDENT PROTEASE ATP-BINDING SUBUNIT CLPC2 |
| M. tuberculosis H37Rv | Rv3596c | clpC1 | 9e-21 | 38.61% (158) | ATP-dependent protease ATP-binding subunit ClpC1 |
| M. tuberculosis H37Rv | Rv0384c | clpB | 4e-07 | 30.91% (110) | endopeptidase ATP binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2686 | clpX' | 1e-141 | 100.00% (252) | ATP-dependent protease ATP-binding subunit ClpX' |
| M. gilvum PYR-GCK | Mflv_3907 | - | 1e-73 | 59.83% (239) | Clp N terminal domain-containing protein |
| M. leprae Br4923 | MLBr_00235 | clpC | 4e-21 | 38.61% (158) | putative ATP-dependent Clp protease |
| M. abscessus ATCC 19977 | MAB_3938 | - | 3e-44 | 51.72% (203) | putative Clp protease subunit |
| M. marinum M | MMAR_2048 | clpC2 | 1e-105 | 82.13% (235) | ATP-dependent protease ATP-binding subunit ClpC2 |
| M. avium 104 | MAV_3559 | - | 7e-96 | 72.91% (251) | putative ATP-dependent Clp protease ATP-binding subunit |
| M. smegmatis MC2 155 | MSMEG_2792 | - | 2e-80 | 63.83% (235) | Clp amino terminal domain-containing protein |
| M. thermoresistible (build 8) | TH_4139 | - | 8e-83 | 64.41% (236) | PUTATIVE ATP-dependent protease ATP-binding subunit ClpC2 |
| M. ulcerans Agy99 | MUL_3301 | clpC2 | 1e-103 | 79.58% (240) | ATP-dependent protease ATP-binding subunit ClpC2 |
| M. vanbaalenii PYR-1 | Mvan_2497 | - | 9e-75 | 60.78% (232) | Clp N terminal domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLD
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 SLGISLEAVRSQVEDIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGH
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 NYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEA
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 AEAGTGGRGGESGSPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERV
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 MQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTL
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 DLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEG
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 AIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEP
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 TVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
Mflv_3907|M.gilvum_PYR-GCK --------MSDAAKISRPVRLDDLIEVITRVHDE----------------
Mvan_2497|M.vanbaalenii_PYR-1 --------MNDS-KISHPVRLDDLIDVIKQVHDE----------------
MSMEG_2792|M.smegmatis_MC2_155 --------MVEHAKITNPVRLDDLIDGIKHAHTE----------------
Rv2667|M.tuberculosis_H37Rv --------MPEPTPTAYPVRLDELINAIKRVHSD----------------
Mb2686|M.bovis_AF2122/97 --------MPEPTPTAYPVRLDELINAIKRVHSD----------------
MMAR_2048|M.marinum_M --------MAESTKITYPVRLDELIDAIKQVHTN----------------
MUL_3301|M.ulcerans_Agy99 --------MADPTKITYPVRLDELIDAIKQVHTN----------------
MAV_3559|M.avium_104 --------MSEPIRIAHSVRLDELIDAIKTTHPD----------------
TH_4139|M.thermoresistible__bu --------MTEPTRITAPVRLDDLINAITTVHSE----------------
MAB_3938|M.abscessus_ATCC_1997 -------------MAAFPISLDNLIESVRGMHPDGT--------------
MLBr_00235|M.leprae_Br4923 DLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASL
: . * :: : : : :
Mflv_3907|M.gilvum_PYR-GCK -----------------------PLDQLTDAVLAAEALD-----------
Mvan_2497|M.vanbaalenii_PYR-1 -----------------------PLEQLTDAVLAAEALG-----------
MSMEG_2792|M.smegmatis_MC2_155 -----------------------PLEQLTDAVIAADALG-----------
Rv2667|M.tuberculosis_H37Rv -----------------------VLDQLSDAVLAAEHLG-----------
Mb2686|M.bovis_AF2122/97 -----------------------VLDQLSDAVLAAEHLG-----------
MMAR_2048|M.marinum_M -----------------------ALDQLTDAVLAAEHLG-----------
MUL_3301|M.ulcerans_Agy99 -----------------------ALGQLTDAVLAAEHLG-----------
MAV_3559|M.avium_104 -----------------------VLDQLADAVLAAEHLG-----------
TH_4139|M.thermoresistible__bu -----------------------PLEQLATAVLTAEALG-----------
MAB_3938|M.abscessus_ATCC_1997 -----------------------ALDHLSDAMLLAGRLS-----------
MLBr_00235|M.leprae_Br4923 RDREKQLVAQRAEREKQWRSGDLDVIAEVDDEQIAEVLGNWTGIPVFKLT
: * *.
Mflv_3907|M.gilvum_PYR-GCK ------------DVADHLIG-----HFVDQARR-----------------
Mvan_2497|M.vanbaalenii_PYR-1 ------------EVADHLIG-----HFVDQARR-----------------
MSMEG_2792|M.smegmatis_MC2_155 ------------EIADHLIG-----HFVDQARR-----------------
Rv2667|M.tuberculosis_H37Rv ------------EIADHLIG-----HFVDQARR-----------------
Mb2686|M.bovis_AF2122/97 ------------EIADHLIG-----HFVDQARR-----------------
MMAR_2048|M.marinum_M ------------EIADHLIG-----HFVDQARR-----------------
MUL_3301|M.ulcerans_Agy99 ------------EIADHLIG-----HFVDQARG-----------------
MAV_3559|M.avium_104 ------------EVADHLIG-----HFVDQARR-----------------
TH_4139|M.thermoresistible__bu ------------DLADHLIG-----HFVDQARR-----------------
MAB_3938|M.abscessus_ATCC_1997 ------------DHADALIG-----HFVDQARR-----------------
MLBr_00235|M.leprae_Br4923 EAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFI
: . :** : *.:*
Mflv_3907|M.gilvum_PYR-GCK ----SGASWTEIGKCMG------------VTKQAAQKRFVPKTP-TDTAA
Mvan_2497|M.vanbaalenii_PYR-1 ----SGASWTEIGKCMG------------VTKQAAQKRFVPKTP-TDTGA
MSMEG_2792|M.smegmatis_MC2_155 ----SGASWTEIGKCMG------------VTKQAAQKRFVPKVPDFDPTA
Rv2667|M.tuberculosis_H37Rv ----SGASWSDIGKSMG------------VTKQAAQKRFVPRA---EATT
Mb2686|M.bovis_AF2122/97 ----SGASWSDIGKSMG------------VTKQAAQKRFVPRA---EATT
MMAR_2048|M.marinum_M ----SGASWTDIGKSMG------------VTKQAAQKRFVPRA---EATT
MUL_3301|M.ulcerans_Agy99 ----SGASWTDIGKSMG------------VTKQAAQKRFVLRA---EATT
MAV_3559|M.avium_104 ----SGASWTDIGKSMG------------VSKQAAQKRFVPR----EATI
TH_4139|M.thermoresistible__bu ----SGASWTDIGRSMG------------VSKQAAKKRFVPKT---GTAP
MAB_3938|M.abscessus_ATCC_1997 ----SGASWSEIGSSMG------------VSKQAAQKRFVPSVR------
MLBr_00235|M.leprae_Br4923 FAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPG
**.. :::. .:. : :.**.
Mflv_3907|M.gilvum_PYR-GCK LDPDAGFSRFTERAR---------AAVVHAQNEAHAAGNGEIAPAHLVLG
Mvan_2497|M.vanbaalenii_PYR-1 LDPDAGFSRFTPRAR---------AVIVEAQNKAHDAGNPEILPAHLILG
MSMEG_2792|M.smegmatis_MC2_155 LNPEEGFGRFTPRAR---------NVIVVAHNLAHDARNAEITPDHLLLG
Rv2667|M.tuberculosis_H37Rv LDSNQGFRRFTPRAR---------NAVVAAQNAAHGAASSEITPDHLLLG
Mb2686|M.bovis_AF2122/97 LDSNQGFRRFTPRAR---------NAVVAAQNAAHGAASSEITPDHLLLG
MMAR_2048|M.marinum_M LDPEQGFGRFTPRAR---------SAVVAAQNAAHQGANDEITPDHLLLG
MUL_3301|M.ulcerans_Agy99 LDPEQGFGRFTPRAR---------SAVVAAQNAAHQGANDEITPDHLLLG
MAV_3559|M.avium_104 LDPGQGFQRFTPRAR---------GAVVAAQNAAHQAGNREITPDHLLIG
TH_4139|M.thermoresistible__bu LDPHDGFNRFTPRAR---------NVVVGAQNRAHDAGNPEIGPEHLLLG
MAB_3938|M.abscessus_ATCC_1997 -----MFSRFTDRAR---------RSVVGAAGFALADGTP-ITVDHLLAG
MLBr_00235|M.leprae_Br4923 YVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDG
::* :.* : * : :* *
Mflv_3907|M.gilvum_PYR-GCK LFSDPSGLAAQLVAAQGIALDGIR----DRIVLPARSEDVPAL-------
Mvan_2497|M.vanbaalenii_PYR-1 MFADPTGLAARLVAGQGVDLAAVA----DHITLPARVDGVPAL-------
MSMEG_2792|M.smegmatis_MC2_155 LFADTEGLAAKLLAGQGVDADAVR----AAVTLPPSTGEAAAL-------
Rv2667|M.tuberculosis_H37Rv VLTDPAALATALLQQQEIDIATLR----TAVTLPPAVTEPPQP-------
Mb2686|M.bovis_AF2122/97 VLTDPAALATALLQQQEIDIATLR----TAVTLPPAVTEPPQP-------
MMAR_2048|M.marinum_M VLADPAALATALLRMQAIDTEALR----ASVRLPAATGETPAL-------
MUL_3301|M.ulcerans_Agy99 VLADPAALATALLRMQAIDTEALR----ASVRLPAATGETPAL-------
MAV_3559|M.avium_104 VLSDPAALATVLLRLQHVDTDALRDAATASIAALRADGDPPAL-------
TH_4139|M.thermoresistible__bu MLDDADALAVRLIDAQGVDPVSLR----GAIRLPDRSADVPKL-------
MAB_3938|M.abscessus_ATCC_1997 AISDPKGLAAVIVAQAGITADALG---IPERPAPDYDAVAPTLST-----
MLBr_00235|M.leprae_Br4923 QGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDE
. :: : :
Mflv_3907|M.gilvum_PYR-GCK ----------------VPFDGRAKKALELTFRHALRLGHNYIGTEHLLLA
Mvan_2497|M.vanbaalenii_PYR-1 ----------------IPFDTRAKKALELTFRQALRLGHNYVGTEHLLLA
MSMEG_2792|M.smegmatis_MC2_155 ----------------IPFDTAAKKALELTFRQALRLGHNYIGTEHILLA
Rv2667|M.tuberculosis_H37Rv ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHLLLA
Mb2686|M.bovis_AF2122/97 ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHLLLA
MMAR_2048|M.marinum_M ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHMLLA
MUL_3301|M.ulcerans_Agy99 ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHMLLA
MAV_3559|M.avium_104 ----------------IPFSGPARKVLELTVREALRLGHNYVGTEHQLLA
TH_4139|M.thermoresistible__bu ----------------IPFNAAARKVLELTVREALRLGHNYVGTEHILLA
MAB_3938|M.abscessus_ATCC_1997 ----------------AEFDGDAQEALEATLHIALRLGHNFIGTEHLLLA
MLBr_00235|M.leprae_Br4923 LKKHFRPEFLNRIDDIIVFHQLSRDEIIRMVDLMISRVANQLKVKDMTLE
* ::. : . : * : .:. *
Mflv_3907|M.gilvum_PYR-GCK LYE-EEDADGVLHGVGIDAERFERDLRQALDGLPGT--------------
Mvan_2497|M.vanbaalenii_PYR-1 LYE-EEDDDGVLHGLGIDFDRFERELREALEAFSGQ--------------
MSMEG_2792|M.smegmatis_MC2_155 LVD-AEDGDGPLHRLGVDAERFEADLRTALEPFMTKPAE-----------
Rv2667|M.tuberculosis_H37Rv LLE-LEDGDGPLHRSGVDKSRAEADLITTLASLTGANAAGATDAGATDAG
Mb2686|M.bovis_AF2122/97 LLE-LEDGDGPLHRSGVDKSRAEADLITTLASLTGANAAGATDAGATDAG
MMAR_2048|M.marinum_M LLE-LEDGAGPLHRSGVEKSRAEADLSSALESLTGHGPDSRPGKS-----
MUL_3301|M.ulcerans_Agy99 LLE-LEDGAGPLHRSGVEKSRAEADLSSALESLTGHGPDGRPGKS-----
MAV_3559|M.avium_104 LLE-LEDGDGLLHRGGVDKERVEVDLIRALESLGSGKNVGAGEDG-----
TH_4139|M.thermoresistible__bu LLE-HEDGEGPLHTAGITKDRTERDLVRILDSLTPKR-------------
MAB_3938|M.abscessus_ATCC_1997 ILSGHTDTSRRLSELGLNAVVAEEQVTRLLGEILQGRTP-----------
MLBr_00235|M.leprae_Br4923 LTN---KAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPG
: . . * *. : :
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 QVVTVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVE
Mflv_3907|M.gilvum_PYR-GCK -
Mvan_2497|M.vanbaalenii_PYR-1 -
MSMEG_2792|M.smegmatis_MC2_155 -
Rv2667|M.tuberculosis_H37Rv -
Mb2686|M.bovis_AF2122/97 -
MMAR_2048|M.marinum_M -
MUL_3301|M.ulcerans_Agy99 -
MAV_3559|M.avium_104 -
TH_4139|M.thermoresistible__bu -
MAB_3938|M.abscessus_ATCC_1997 -
MLBr_00235|M.leprae_Br4923 Q