For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAAFPISLDNLIESVRGMHPDGTALDHLSDAMLLAGRLSDHADALIGHFVDQARRSGASWSEIGSSMGVS KQAAQKRFVPSVRMFSRFTDRARRSVVGAAGFALADGTPITVDHLLAGAISDPKGLAAVIVAQAGITADA LGIPERPAPDYDAVAPTLSTAEFDGDAQEALEATLHIALRLGHNFIGTEHLLLAILSGHTDTSRRLSELG LNAVVAEEQVTRLLGEILQGRTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3938 | - | - | 100% (233) | putative Clp protease subunit |
| M. abscessus ATCC 19977 | MAB_0546 | - | 2e-14 | 36.36% (143) | ATP-dependent Clp protease ATP-binding subunit |
| M. abscessus ATCC 19977 | MAB_4265c | - | 4e-06 | 22.30% (139) | chaperone ClpB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2686 | clpX' | 2e-44 | 51.72% (203) | ATP-dependent protease ATP-binding subunit ClpX' |
| M. gilvum PYR-GCK | Mflv_3907 | - | 2e-45 | 50.00% (240) | Clp N terminal domain-containing protein |
| M. tuberculosis H37Rv | Rv2667 | clpC2 | 2e-44 | 51.72% (203) | ATP-dependent protease ATP-binding subunit ClpC2 |
| M. leprae Br4923 | MLBr_00235 | clpC | 3e-15 | 37.06% (143) | putative ATP-dependent Clp protease |
| M. marinum M | MMAR_2048 | clpC2 | 8e-44 | 46.25% (240) | ATP-dependent protease ATP-binding subunit ClpC2 |
| M. avium 104 | MAV_3559 | - | 7e-43 | 50.73% (205) | putative ATP-dependent Clp protease ATP-binding subunit |
| M. smegmatis MC2 155 | MSMEG_2792 | - | 1e-42 | 47.06% (221) | Clp amino terminal domain-containing protein |
| M. thermoresistible (build 8) | TH_4139 | - | 4e-41 | 44.49% (236) | PUTATIVE ATP-dependent protease ATP-binding subunit ClpC2 |
| M. ulcerans Agy99 | MUL_3301 | clpC2 | 3e-41 | 45.00% (240) | ATP-dependent protease ATP-binding subunit ClpC2 |
| M. vanbaalenii PYR-1 | Mvan_2497 | - | 8e-41 | 49.06% (212) | Clp N terminal domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKSLD
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 SLGISLEAVRSQVEDIIGQGQQAPSGHIPFTPRAKKVLELSLREALQLGH
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 NYIGTEHILLGLIREGEGVAAQVLVKLGAELTRVRQQVIQLLSGYQGKEA
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 AEAGTGGRGGESGSPSTSLVLDQFGRNLTAAAMESKLDPVIGREKEIERV
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 MQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTL
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 DLGSLVAGSRYRGDFEERLKKVLKEINTRGDIILFIDELHTLVGAGAAEG
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 AIDAASILKPKLARGELQTIGATTLDEYRKYIEKDAALERRFQPVQVGEP
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 TVEHTIEILKGLRDRYEAHHRVSITDSAMVAAATLADRYINDRFLPDKAI
Mb2686|M.bovis_AF2122/97 --------MPEPTPTAYPVRLDELINAIKRVHSD----------------
Rv2667|M.tuberculosis_H37Rv --------MPEPTPTAYPVRLDELINAIKRVHSD----------------
MMAR_2048|M.marinum_M --------MAESTKITYPVRLDELIDAIKQVHTN----------------
MUL_3301|M.ulcerans_Agy99 --------MADPTKITYPVRLDELIDAIKQVHTN----------------
MAV_3559|M.avium_104 --------MSEPIRIAHSVRLDELIDAIKTTHPD----------------
TH_4139|M.thermoresistible__bu --------MTEPTRITAPVRLDDLINAITTVHSE----------------
Mflv_3907|M.gilvum_PYR-GCK --------MSDAAKISRPVRLDDLIEVITRVHDE----------------
Mvan_2497|M.vanbaalenii_PYR-1 --------MNDS-KISHPVRLDDLIDVIKQVHDE----------------
MSMEG_2792|M.smegmatis_MC2_155 --------MVEHAKITNPVRLDDLIDGIKHAHTE----------------
MAB_3938|M.abscessus_ATCC_1997 -------------MAAFPISLDNLIESVRGMHPDGT--------------
MLBr_00235|M.leprae_Br4923 DLIDEAGARMRIRRMTAPPDLREFDEKIAEARREKESAIDAQDFEKAASL
: . * :: : : : :
Mb2686|M.bovis_AF2122/97 -----------------------VLDQLSDAVLAAEHLG-----------
Rv2667|M.tuberculosis_H37Rv -----------------------VLDQLSDAVLAAEHLG-----------
MMAR_2048|M.marinum_M -----------------------ALDQLTDAVLAAEHLG-----------
MUL_3301|M.ulcerans_Agy99 -----------------------ALGQLTDAVLAAEHLG-----------
MAV_3559|M.avium_104 -----------------------VLDQLADAVLAAEHLG-----------
TH_4139|M.thermoresistible__bu -----------------------PLEQLATAVLTAEALG-----------
Mflv_3907|M.gilvum_PYR-GCK -----------------------PLDQLTDAVLAAEALD-----------
Mvan_2497|M.vanbaalenii_PYR-1 -----------------------PLEQLTDAVLAAEALG-----------
MSMEG_2792|M.smegmatis_MC2_155 -----------------------PLEQLTDAVIAADALG-----------
MAB_3938|M.abscessus_ATCC_1997 -----------------------ALDHLSDAMLLAGRLS-----------
MLBr_00235|M.leprae_Br4923 RDREKQLVAQRAEREKQWRSGDLDVIAEVDDEQIAEVLGNWTGIPVFKLT
: * *.
Mb2686|M.bovis_AF2122/97 ------------EIADHLIG-----HFVDQARR-----------------
Rv2667|M.tuberculosis_H37Rv ------------EIADHLIG-----HFVDQARR-----------------
MMAR_2048|M.marinum_M ------------EIADHLIG-----HFVDQARR-----------------
MUL_3301|M.ulcerans_Agy99 ------------EIADHLIG-----HFVDQARG-----------------
MAV_3559|M.avium_104 ------------EVADHLIG-----HFVDQARR-----------------
TH_4139|M.thermoresistible__bu ------------DLADHLIG-----HFVDQARR-----------------
Mflv_3907|M.gilvum_PYR-GCK ------------DVADHLIG-----HFVDQARR-----------------
Mvan_2497|M.vanbaalenii_PYR-1 ------------EVADHLIG-----HFVDQARR-----------------
MSMEG_2792|M.smegmatis_MC2_155 ------------EIADHLIG-----HFVDQARR-----------------
MAB_3938|M.abscessus_ATCC_1997 ------------DHADALIG-----HFVDQARR-----------------
MLBr_00235|M.leprae_Br4923 EAETTRLLRMEEELHKRIIGQEDAVKAVSKAIRRTRAGLKDPKRPSGSFI
: . :** : *.:*
Mb2686|M.bovis_AF2122/97 ----SGASWSDIGKSMG------------VTKQAAQKRFVPRA---EATT
Rv2667|M.tuberculosis_H37Rv ----SGASWSDIGKSMG------------VTKQAAQKRFVPRA---EATT
MMAR_2048|M.marinum_M ----SGASWTDIGKSMG------------VTKQAAQKRFVPRA---EATT
MUL_3301|M.ulcerans_Agy99 ----SGASWTDIGKSMG------------VTKQAAQKRFVLRA---EATT
MAV_3559|M.avium_104 ----SGASWTDIGKSMG------------VSKQAAQKRFVPR----EATI
TH_4139|M.thermoresistible__bu ----SGASWTDIGRSMG------------VSKQAAKKRFVPKT---GTAP
Mflv_3907|M.gilvum_PYR-GCK ----SGASWTEIGKCMG------------VTKQAAQKRFVPKTP-TDTAA
Mvan_2497|M.vanbaalenii_PYR-1 ----SGASWTEIGKCMG------------VTKQAAQKRFVPKTP-TDTGA
MSMEG_2792|M.smegmatis_MC2_155 ----SGASWTEIGKCMG------------VTKQAAQKRFVPKVPDFDPTA
MAB_3938|M.abscessus_ATCC_1997 ----SGASWSEIGSSMG------------VSKQAAQKRFVPSVR------
MLBr_00235|M.leprae_Br4923 FAGPSGVGKTELSKALANFLFGDDDALIQIDMGEFHDRFTASRLFGAPPG
**.. :::. .:. : :.**.
Mb2686|M.bovis_AF2122/97 LDSNQGFRRFTPRAR---------NAVVAAQNAAHGAASSEITPDHLLLG
Rv2667|M.tuberculosis_H37Rv LDSNQGFRRFTPRAR---------NAVVAAQNAAHGAASSEITPDHLLLG
MMAR_2048|M.marinum_M LDPEQGFGRFTPRAR---------SAVVAAQNAAHQGANDEITPDHLLLG
MUL_3301|M.ulcerans_Agy99 LDPEQGFGRFTPRAR---------SAVVAAQNAAHQGANDEITPDHLLLG
MAV_3559|M.avium_104 LDPGQGFQRFTPRAR---------GAVVAAQNAAHQAGNREITPDHLLIG
TH_4139|M.thermoresistible__bu LDPHDGFNRFTPRAR---------NVVVGAQNRAHDAGNPEIGPEHLLLG
Mflv_3907|M.gilvum_PYR-GCK LDPDAGFSRFTERAR---------AAVVHAQNEAHAAGNGEIAPAHLVLG
Mvan_2497|M.vanbaalenii_PYR-1 LDPDAGFSRFTPRAR---------AVIVEAQNKAHDAGNPEILPAHLILG
MSMEG_2792|M.smegmatis_MC2_155 LNPEEGFGRFTPRAR---------NVIVVAHNLAHDARNAEITPDHLLLG
MAB_3938|M.abscessus_ATCC_1997 -----MFSRFTDRAR---------RSVVGAAGFALADGTP-ITVDHLLAG
MLBr_00235|M.leprae_Br4923 YVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQEIYNSLLQVLEDGRLTDG
::* :.* : * : :* *
Mb2686|M.bovis_AF2122/97 VLTDPAALATALLQQQEIDIATLR----TAVTLPPAVTEPPQP-------
Rv2667|M.tuberculosis_H37Rv VLTDPAALATALLQQQEIDIATLR----TAVTLPPAVTEPPQP-------
MMAR_2048|M.marinum_M VLADPAALATALLRMQAIDTEALR----ASVRLPAATGETPAL-------
MUL_3301|M.ulcerans_Agy99 VLADPAALATALLRMQAIDTEALR----ASVRLPAATGETPAL-------
MAV_3559|M.avium_104 VLSDPAALATVLLRLQHVDTDALRDAATASIAALRADGDPPAL-------
TH_4139|M.thermoresistible__bu MLDDADALAVRLIDAQGVDPVSLR----GAIRLPDRSADVPKL-------
Mflv_3907|M.gilvum_PYR-GCK LFSDPSGLAAQLVAAQGIALDGIR----DRIVLPARSEDVPAL-------
Mvan_2497|M.vanbaalenii_PYR-1 MFADPTGLAARLVAGQGVDLAAVA----DHITLPARVDGVPAL-------
MSMEG_2792|M.smegmatis_MC2_155 LFADTEGLAAKLLAGQGVDADAVR----AAVTLPPSTGEAAAL-------
MAB_3938|M.abscessus_ATCC_1997 AISDPKGLAAVIVAQAGITADALG---IPERPAPDYDAVAPTLST-----
MLBr_00235|M.leprae_Br4923 QGRTVDFKNTVLIFTSNLGTSDISKPVGLGFTQGSGENDYERMKQKVNDE
. :: : :
Mb2686|M.bovis_AF2122/97 ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHLLLA
Rv2667|M.tuberculosis_H37Rv ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHLLLA
MMAR_2048|M.marinum_M ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHMLLA
MUL_3301|M.ulcerans_Agy99 ----------------IPFSGPARKVLELTFREALRLGHNYIGTEHMLLA
MAV_3559|M.avium_104 ----------------IPFSGPARKVLELTVREALRLGHNYVGTEHQLLA
TH_4139|M.thermoresistible__bu ----------------IPFNAAARKVLELTVREALRLGHNYVGTEHILLA
Mflv_3907|M.gilvum_PYR-GCK ----------------VPFDGRAKKALELTFRHALRLGHNYIGTEHLLLA
Mvan_2497|M.vanbaalenii_PYR-1 ----------------IPFDTRAKKALELTFRQALRLGHNYVGTEHLLLA
MSMEG_2792|M.smegmatis_MC2_155 ----------------IPFDTAAKKALELTFRQALRLGHNYIGTEHILLA
MAB_3938|M.abscessus_ATCC_1997 ----------------AEFDGDAQEALEATLHIALRLGHNFIGTEHLLLA
MLBr_00235|M.leprae_Br4923 LKKHFRPEFLNRIDDIIVFHQLSRDEIIRMVDLMISRVANQLKVKDMTLE
* ::. : . : * : .:. *
Mb2686|M.bovis_AF2122/97 LLE-LEDGDGPLHRSGVDKSRAEADLITTLASLTGANAAGATDAGATDAG
Rv2667|M.tuberculosis_H37Rv LLE-LEDGDGPLHRSGVDKSRAEADLITTLASLTGANAAGATDAGATDAG
MMAR_2048|M.marinum_M LLE-LEDGAGPLHRSGVEKSRAEADLSSALESLTGHGPDSRPGKS-----
MUL_3301|M.ulcerans_Agy99 LLE-LEDGAGPLHRSGVEKSRAEADLSSALESLTGHGPDGRPGKS-----
MAV_3559|M.avium_104 LLE-LEDGDGLLHRGGVDKERVEVDLIRALESLGSGKNVGAGEDG-----
TH_4139|M.thermoresistible__bu LLE-HEDGEGPLHTAGITKDRTERDLVRILDSLTPKR-------------
Mflv_3907|M.gilvum_PYR-GCK LYE-EEDADGVLHGVGIDAERFERDLRQALDGLPGT--------------
Mvan_2497|M.vanbaalenii_PYR-1 LYE-EEDDDGVLHGLGIDFDRFERELREALEAFSGQ--------------
MSMEG_2792|M.smegmatis_MC2_155 LVD-AEDGDGPLHRLGVDAERFEADLRTALEPFMTKPAE-----------
MAB_3938|M.abscessus_ATCC_1997 ILSGHTDTSRRLSELGLNAVVAEEQVTRLLGEILQGRTP-----------
MLBr_00235|M.leprae_Br4923 LTN---KAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPG
: . . * *. : :
Mb2686|M.bovis_AF2122/97 --------------------------------------------------
Rv2667|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2048|M.marinum_M --------------------------------------------------
MUL_3301|M.ulcerans_Agy99 --------------------------------------------------
MAV_3559|M.avium_104 --------------------------------------------------
TH_4139|M.thermoresistible__bu --------------------------------------------------
Mflv_3907|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2497|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2792|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3938|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00235|M.leprae_Br4923 QVVTVDVDNWDGEGPGEDVKFTFTGIRKPSTEPDLAKAGVHSAGGPEPVE
Mb2686|M.bovis_AF2122/97 -
Rv2667|M.tuberculosis_H37Rv -
MMAR_2048|M.marinum_M -
MUL_3301|M.ulcerans_Agy99 -
MAV_3559|M.avium_104 -
TH_4139|M.thermoresistible__bu -
Mflv_3907|M.gilvum_PYR-GCK -
Mvan_2497|M.vanbaalenii_PYR-1 -
MSMEG_2792|M.smegmatis_MC2_155 -
MAB_3938|M.abscessus_ATCC_1997 -
MLBr_00235|M.leprae_Br4923 Q