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NVLGASWFHWAIGIAIGVPVDLILLTELHNSLARRNSHLARQVTLLRNFLLPLGALLLFLVKASQVPAGE GTVRILTTVFGFLVLVLLLSALNATVFASAPQDSWRKRLPTIFLDVARFALIGIGLAMILSYVWGVRVGG IFTALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTGLRITP NSVLATTAFTNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATVALGGAEYRTTV RIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDSYSTPQRVQDALRAVSPELKLSLLDQQSLAPYAKV VRYGTDETVQQAGVVPKGMSFIIAGSVRLMVTPADGPAVVVGTLGKGVFLGVTALTRQPNPGGAVALEEV TVLDIDREYLERIVMSKPALLQELGRLIDEQQMKVRQVTQRERVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3699 | - | - | 100% (466) | hypothetical protein MUL_3699 |
| M. ulcerans Agy99 | MUL_3697 | - | e-170 | 64.57% (460) | hypothetical protein MUL_3697 |
| M. ulcerans Agy99 | MUL_2773 | - | 2e-07 | 25.60% (250) | hypothetical protein MUL_2773 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2460c | - | 0.0 | 74.57% (464) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1046 | - | 2e-07 | 24.19% (248) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv2434c | - | 0.0 | 74.57% (464) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1411 | - | 4e-06 | 26.83% (164) | putative mechanosensitive ion channel |
| M. marinum M | MMAR_3756 | - | 0.0 | 98.50% (466) | hypothetical protein MMAR_3756 |
| M. avium 104 | MAV_3202 | - | 1e-161 | 60.99% (464) | transmembrane protein |
| M. smegmatis MC2 155 | MSMEG_3579 | - | 1e-153 | 57.33% (457) | transmembrane protein |
| M. thermoresistible (build 8) | TH_2299 | - | 1e-153 | 56.83% (461) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_3795 | - | 1e-06 | 27.09% (203) | MscS mechanosensitive ion channel |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3699|M.ulcerans_Agy99 --------MNVLGASWFHWAIGIAIGVPVDLILLTELHNSLARRNSHLAR
MMAR_3756|M.marinum_M --------MNVLGASWFHWAVGIAIGVPVGLILLTELHNSLARRNSHLAR
Mb2460c|M.bovis_AF2122/97 --------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLAR
Rv2434c|M.tuberculosis_H37Rv --------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLAR
MAV_3202|M.avium_104 --------MSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRKHSPLAR
MSMEG_3579|M.smegmatis_MC2_155 -------MRSVLEANWFYWALSVAVGLPIGLVLLTELHNTLARHGSYLAR
TH_2299|M.thermoresistible__bu -------VSLALDGAWLYWAIGVAVGFPAALILLTELHDAMVRRNSIMAR
MAB_1411|M.abscessus_ATCC_1997 ----MSDLAIQLSESGRDWLIHRPVDIAIYVVLALAVRYVLHRAIDRLVQ
Mvan_3795|M.vanbaalenii_PYR-1 --MDVSLLAFEWTDTSRHWLIEVPIRIVAYLTVALVIRFVVHRMIDRATT
Mflv_1046|M.gilvum_PYR-GCK MDDTLELASATHVASAAAWIAGAVAIAYAVGLAISWLLQRLGRRSTLLHH
* : *
MUL_3699|M.ulcerans_Agy99 QVTLLRNFLLPLGALLLFLVKASQVPAGEGTVRILTTVFGFLVLVLLLSA
MMAR_3756|M.marinum_M QVTLLRNFLLPLGALLLFLVKASQVPAGEGTVRILTTVFGFLVLVLLLSA
Mb2460c|M.bovis_AF2122/97 QASLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSL
Rv2434c|M.tuberculosis_H37Rv QASLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSL
MAV_3202|M.avium_104 PAFLLRSYLIPLGALLVLLVNVARMPAQFTSVRVLATAFGFVVVVLLLSG
MSMEG_3579|M.smegmatis_MC2_155 PVSLLRNYILPLAALLILLVKGSEISAEATPVRIVATGFGFVVIILLLSG
TH_2299|M.thermoresistible__bu PVQLLRNYLLPLAALLILLVQAVEVSTEATPVRIVATAFSFAVLILLLSG
MAB_1411|M.abscessus_ATCC_1997 GARRPESAEHPRRQWWAFLRRGRDLGESDRLDETARLPARTRTLRGRAQD
Mvan_3795|M.vanbaalenii_PYR-1 SRTR-----------------------KDKDAAGARTPPLVRKLRDRVPS
Mflv_1046|M.gilvum_PYR-GCK AAELTRMPLRATLVVIAASAAVRRTVDADTGWRGFVDHLLVITLIATITW
:
MUL_3699|M.ulcerans_Agy99 LNATVFASAPQDSW---------------------RKRLPTIFLDVARFA
MMAR_3756|M.marinum_M LNATVFASAPQDSW---------------------RKRLPTIFLDVARFA
Mb2460c|M.bovis_AF2122/97 LNATLFQGAPQQSW---------------------RKRLPAIFVDVARFA
Rv2434c|M.tuberculosis_H37Rv LNATLFQGAPQQSW---------------------RKRLPAIFVDVARFA
MAV_3202|M.avium_104 LNATIFEGAPEGSW---------------------RQRVPGIFLDVTRFV
MSMEG_3579|M.smegmatis_MC2_155 LNATLFQGAPEGSW---------------------RKRIPSIFLDVARFA
TH_2299|M.thermoresistible__bu LNATLFHGAPEDTW---------------------RKRIPTIFVDVARFA
MAB_1411|M.abscessus_ATCC_1997 PARDARRRKRRAQR---------------------AQTLGSVLKSAVSFL
Mvan_3795|M.vanbaalenii_PYR-1 SASSEQVIARRQQR---------------------AQTIGSVLKSTVSIV
Mflv_1046|M.gilvum_PYR-GCK TIASLVRVAERQAISRFAGGDEGLTDADRHRRKIKTQVLTLRRIAVAIIV
. : : .. :
MUL_3699|M.ulcerans_Agy99 LIGIGLAMILSYVWGVRVGGIFTALGVTSVVIGLMLQNSVGQIVSGLFML
MMAR_3756|M.marinum_M LIGIGLAMILSYVWGVRVGGIFTALGVTSVVIGLMLQNSVGQIVSGLFML
Mb2460c|M.bovis_AF2122/97 LIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFML
Rv2434c|M.tuberculosis_H37Rv LIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFML
MAV_3202|M.avium_104 LIGVGLAVIFSYVWGVRVGGLFTALGVTSVVIGLMLQNSVGQIVSGLFML
MSMEG_3579|M.smegmatis_MC2_155 LIAVGVGMIMAYVWGANVGGLFTALGVTSIVLGLALQNAVGQIISGLLLL
TH_2299|M.thermoresistible__bu LIAVGLALILAYIWGANVGGLFTALGVSSIVLGLALQNAVGQIVSGLLVL
MAB_1411|M.abscessus_ATCC_1997 VL-VWVILQSLAILGVNVAPFIASAGIVGVALGFGAQNLVRDFITGIFML
Mvan_3795|M.vanbaalenii_PYR-1 LL-VWVVLAVLNVLGVNIAPFIASAGVVGLAIGFGAQNLVRDFVTGVFML
Mflv_1046|M.gilvum_PYR-GCK MLGAAAALMTFPAFSDIGKTVFASAGVLTVVAGLAAQTSLGSVFAGIQIA
:: : . .::: *: :. *: *. : ...:*: :
MUL_3699|M.ulcerans_Agy99 FEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTG-LRITPNSVLATTAF
MMAR_3756|M.marinum_M FEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTG-LRITPNSVLATTAF
Mb2460c|M.bovis_AF2122/97 FEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAF
Rv2434c|M.tuberculosis_H37Rv FEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAF
MAV_3202|M.avium_104 FEQPFRIGDWLDTPAARGRIVEANWRSVHIQTGHG-LQITPNSVLATTSF
MSMEG_3579|M.smegmatis_MC2_155 FEQPFQLGDWLDTPSARGRVVEVNWRATHIDTGGG-LQIMPNSVLAGASF
TH_2299|M.thermoresistible__bu FEQPFQIGDWVDTPSARGKVVEVNWRATHIDTGGG-LRVIPNSELADASF
MAB_1411|M.abscessus_ATCC_1997 FEDQYGVGDVVDVGDAVGTVESVGLRITTVRDLQGTLWYVRNGGIARVG-
Mvan_3795|M.vanbaalenii_PYR-1 LEDQYGVGDTVDLGEAVGEVESVGLRITTVRDIDGTLWYVRNGEIARVG-
Mflv_1046|M.gilvum_PYR-GCK FSDAIRVGDVVVLEEEWGRIEEITLTYVVVHLWDERRLVLPCTYFTSTPF
:.: :.* : * : . . : :: .
MUL_3699|M.ulcerans_Agy99 TNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATV
MMAR_3756|M.marinum_M TNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATV
Mb2460c|M.bovis_AF2122/97 TNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATI
Rv2434c|M.tuberculosis_H37Rv TNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATI
MAV_3202|M.avium_104 TNLSRPPGGHQLTLTATFSETDPPDRVCALLRRVADALPQRRPDAVAAAV
MSMEG_3579|M.smegmatis_MC2_155 TNLSRPEAAHSLSVTTTFGVSDSPDAVCALLTRVATQLPQRRAGAAPKAI
TH_2299|M.thermoresistible__bu TNLSRPPGTHTITVPTVFAGGDAPDQVCAMLTRVAANLPQLLPGAEPSAA
MAB_1411|M.abscessus_ATCC_1997 -NFSQDYAVAFLQIPLSYSAD-----------------------------
Mvan_3795|M.vanbaalenii_PYR-1 -NMSQEYAVARIEVPVALTAD-----------------------------
Mflv_1046|M.gilvum_PYR-GCK QNWTRNATELLGTAELDVDFTVPFDQMRAELDRLLRANP-----------
* ::
MUL_3699|M.ulcerans_Agy99 ALGGAEYRTTVRIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDSYST
MMAR_3756|M.marinum_M ALGGAEYRTTVRIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDTFST
Mb2460c|M.bovis_AF2122/97 ARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFST
Rv2434c|M.tuberculosis_H37Rv ARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFST
MAV_3202|M.avium_104 PAGGGEYHVTIGLTSPADDSAAQATLLRWLWYGARREGLRLDGAEDDIST
MSMEG_3579|M.smegmatis_MC2_155 PLGAGEYKTSIPLRTPADDSAARAVFLRWLWYAARRAELHLDGETDDFST
TH_2299|M.thermoresistible__bu PAGRGEYRTSIPLRTPADDATARSTFLRWVWYAARRAGLHLDRSTDDFVT
MAB_1411|M.abscessus_ATCC_1997 ---------------------------------------------VDLAC
Mvan_3795|M.vanbaalenii_PYR-1 ---------------------------------------------VDRAE
Mflv_1046|M.gilvum_PYR-GCK -------------------------------------------LWDGRVG
MUL_3699|M.ulcerans_Agy99 PQRVQDALRAVS-PELKLSLLDQQSLAPYAKVVRYGTDETVQQAGVVPKG
MMAR_3756|M.marinum_M PQRVQDALRAVS-PELKLSLLDQQSLAPYAKVVRYGTDETVQQAGVVPKG
Mb2460c|M.bovis_AF2122/97 AERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMG
Rv2434c|M.tuberculosis_H37Rv AERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMG
MAV_3202|M.avium_104 PERIERALRMVVAPALRLGPPDQQALVSHARIVRYGADEIVEHAGRVPEK
MSMEG_3579|M.smegmatis_MC2_155 PERLTKAVRQMA-PTLRLSHTEQQEVLNHSALVRFGADEIIQEAGEIPTR
TH_2299|M.thermoresistible__bu TERLTTALAAIA-PALRLSEAEQQDLLPRAGIARYGAGEPIQVAGEVPSH
MAB_1411|M.abscessus_ATCC_1997 TIALEAAREAVAEEALRDDVIGAPEMLGIDGIT----------ADAISLR
Mvan_3795|M.vanbaalenii_PYR-1 QVAHEAAQEAVADPALAGKVIGEPEMLGVQELS----------PDLIKLR
Mflv_1046|M.gilvum_PYR-GCK VLQVTDAVEGRVRVRMLVSASNAGQLFDLRCDVREGMVAWLQRTNPGAMP
* : : ..
MUL_3699|M.ulcerans_Agy99 MSFIIAGSVRLMVTPADGPAVVVGTLGKGVFLGVTALTRQPNPGGAVALE
MMAR_3756|M.marinum_M MSFIIAGSVRLMVTPADGPAVAVGTLGKGAFLGVTALTRQPNPGGAVALE
Mb2460c|M.bovis_AF2122/97 ITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
Rv2434c|M.tuberculosis_H37Rv ITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
MAV_3202|M.avium_104 MTFLLAGGVRLTATAPDGSVVAVGGLDEGSFLGVTALTRQPNLADAQAVA
MSMEG_3579|M.smegmatis_MC2_155 MSFIVSGRVGVSVAGDGDAVIPVRTLTENDFLGQTALTREGALASAHALT
TH_2299|M.thermoresistible__bu MTFVVRGRVRVVAPLADGSAVEVRIAGPGDFLGQSTLTREPVSTSAYAVD
MAB_1411|M.abscessus_ATCC_1997 LTVAVRANAQWAVERELRRRILIAFDENG---------------------
Mvan_3795|M.vanbaalenii_PYR-1 MTVKVRPNAQWAVQRKLRRAILRAYDEHG---------------------
Mflv_1046|M.gilvum_PYR-GCK RTRIEHRTDADTARGDAAVPVPGRSQADSG--------------------
: . : .
MUL_3699|M.ulcerans_Agy99 EVTVLDIDREYLERIVMSKPALLQELGRLIDEQQMKVRQVTQRERVA---
MMAR_3756|M.marinum_M EVTVLDIDREYLERIVMSKPALLQELGRLIDERQMKVRQVTQRERVA---
Mb2460c|M.bovis_AF2122/97 EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPA
Rv2434c|M.tuberculosis_H37Rv EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPA
MAV_3202|M.avium_104 EVTALEIDREHLVELVTGKPLLLQDLGRTIDERRALVHRAVTAEPTPSRE
MSMEG_3579|M.smegmatis_MC2_155 ETTVLQISREFLEELVAGNPLLLLELSRIIDDRRSAARAALTAD------
TH_2299|M.thermoresistible__bu EVTVVELERTVLEDLVTRKPVLLQDIGRAIEERRLMARRAVTTQR-----
MAB_1411|M.abscessus_ATCC_1997 ------IRPLYLDGLSSGTVETLEKASR----------------------
Mvan_3795|M.vanbaalenii_PYR-1 ------IDLPYPGGR-----MQVAAASE----------------------
Mflv_1046|M.gilvum_PYR-GCK ------LFSGSIAADRRNRDLTWAHDAR----------------------
: ..
MUL_3699|M.ulcerans_Agy99 -----------
MMAR_3756|M.marinum_M -----------
Mb2460c|M.bovis_AF2122/97 AAGEHRGPARR
Rv2434c|M.tuberculosis_H37Rv AAGEHRGPARR
MAV_3202|M.avium_104 PVS--------
MSMEG_3579|M.smegmatis_MC2_155 -----------
TH_2299|M.thermoresistible__bu -----------
MAB_1411|M.abscessus_ATCC_1997 -----------
Mvan_3795|M.vanbaalenii_PYR-1 -----------
Mflv_1046|M.gilvum_PYR-GCK -----------