For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRSVLEANWFYWALSVAVGLPIGLVLLTELHNTLARHGSYLARPVSLLRNYILPLAALLILLVKGSEISA EATPVRIVATGFGFVVIILLLSGLNATLFQGAPEGSWRKRIPSIFLDVARFALIAVGVGMIMAYVWGANV GGLFTALGVTSIVLGLALQNAVGQIISGLLLLFEQPFQLGDWLDTPSARGRVVEVNWRATHIDTGGGLQI MPNSVLAGASFTNLSRPEAAHSLSVTTTFGVSDSPDAVCALLTRVATQLPQRRAGAAPKAIPLGAGEYKT SIPLRTPADDSAARAVFLRWLWYAARRAELHLDGETDDFSTPERLTKAVRQMAPTLRLSHTEQQEVLNHS ALVRFGADEIIQEAGEIPTRMSFIVSGRVGVSVAGDGDAVIPVRTLTENDFLGQTALTREGALASAHALT ETTVLQISREFLEELVAGNPLLLLELSRIIDDRRSAARAALTAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3579 | - | - | 100% (464) | transmembrane protein |
| M. smegmatis MC2 155 | MSMEG_1315 | - | 5e-07 | 30.39% (102) | transporter, small conductance mechanosensitive ion channel |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2460c | - | 1e-159 | 57.88% (463) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1046 | - | 9e-07 | 26.29% (213) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv2434c | - | 1e-159 | 57.88% (463) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1411 | - | 2e-08 | 28.47% (137) | putative mechanosensitive ion channel |
| M. marinum M | MMAR_3756 | - | 1e-154 | 57.24% (456) | hypothetical protein MMAR_3756 |
| M. avium 104 | MAV_3202 | - | 1e-157 | 58.32% (463) | transmembrane protein |
| M. thermoresistible (build 8) | TH_2299 | - | 1e-173 | 65.80% (459) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3699 | - | 1e-153 | 57.33% (457) | hypothetical protein MUL_3699 |
| M. vanbaalenii PYR-1 | Mvan_5784 | - | 1e-05 | 23.26% (215) | MscS mechanosensitive ion channel |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3579|M.smegmatis_MC2_155 -------MRSVLEANWFYWALSVAVGLPIGLVLLTELHNTLARHGSYLAR
TH_2299|M.thermoresistible__bu -------VSLALDGAWLYWAIGVAVGFPAALILLTELHDAMVRRNSIMAR
Mb2460c|M.bovis_AF2122/97 --------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLAR
Rv2434c|M.tuberculosis_H37Rv --------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLAR
MMAR_3756|M.marinum_M --------MNVLGASWFHWAVGIAIGVPVGLILLTELHNSLARRNSHLAR
MUL_3699|M.ulcerans_Agy99 --------MNVLGASWFHWAIGIAIGVPVDLILLTELHNSLARRNSHLAR
MAV_3202|M.avium_104 --------MSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRKHSPLAR
Mflv_1046|M.gilvum_PYR-GCK MDDTLELASATHVASAAAWIAGAVAIAYAVGLAISWLLQRLGRRSTLLHH
Mvan_5784|M.vanbaalenii_PYR-1 MDDAIEFTSATHLAVTAAWVAGAIGVAYVAGLAVSWLLQRLGRRSAVMHD
MAB_1411|M.abscessus_ATCC_1997 ----MSDLAIQLSESGRDWLIHRPVDIAIYVVLALAVRYVLHRAIDRLVQ
* : : * :
MSMEG_3579|M.smegmatis_MC2_155 PVSLLRNYILPLAALLILLVKGSEISAEATPVR-----------IVATGF
TH_2299|M.thermoresistible__bu PVQLLRNYLLPLAALLILLVQAVEVSTEATPVR-----------IVATAF
Mb2460c|M.bovis_AF2122/97 QASLLRNYLLPLGAVLLLLVKASEVPAEDPTVR-----------VLTTAF
Rv2434c|M.tuberculosis_H37Rv QASLLRNYLLPLGAVLLLLVKASEVPAEDPTVR-----------VLTTAF
MMAR_3756|M.marinum_M QVTLLRNFLLPLGALLLFLVKASQVPAGEGTVR-----------ILTTVF
MUL_3699|M.ulcerans_Agy99 QVTLLRNFLLPLGALLLFLVKASQVPAGEGTVR-----------ILTTVF
MAV_3202|M.avium_104 PAFLLRSYLIPLGALLVLLVNVARMPAQFTSVR-----------VLATAF
Mflv_1046|M.gilvum_PYR-GCK AAELTRMPLRATLVVIAASAAVRRTVDADTGWRGFVDHLLVITLIATITW
Mvan_5784|M.vanbaalenii_PYR-1 VAHLTRLPLRATLVVIAAGAAVRRTTDEQAVWRGWLDHALILALIATLTW
MAB_1411|M.abscessus_ATCC_1997 GARRPESAEHPRRQWWAFLRRGRDLGESD---------------RLDETA
. . .
MSMEG_3579|M.smegmatis_MC2_155 GFVVIILLLSGLNATLFQGAPE-----GSWRKRIPSIFLDVAR-----FA
TH_2299|M.thermoresistible__bu SFAVLILLLSGLNATLFHGAPE-----DTWRKRIPTIFVDVAR-----FA
Mb2460c|M.bovis_AF2122/97 GFLVLVLLLSLLNATLFQGAPQ-----QSWRKRLPAIFVDVAR-----FA
Rv2434c|M.tuberculosis_H37Rv GFLVLVLLLSLLNATLFQGAPQ-----QSWRKRLPAIFVDVAR-----FA
MMAR_3756|M.marinum_M GFLVLVLLLSALNATVFASAPQ-----DSWRKRLPTIFLDVAR-----FA
MUL_3699|M.ulcerans_Agy99 GFLVLVLLLSALNATVFASAPQ-----DSWRKRLPTIFLDVAR-----FA
MAV_3202|M.avium_104 GFVVVVLLLSGLNATIFEGAPE-----GSWRQRVPGIFLDVTR-----FV
Mflv_1046|M.gilvum_PYR-GCK TIASLVRVAERQAISRFAGGDEGLTDADRHRRKIKTQVLTLRRIAVAIIV
Mvan_5784|M.vanbaalenii_PYR-1 VLVSLVRVVERQVIARFAGGDEGLTDADRHRRKIKTQVTVLRRLVVALVV
MAB_1411|M.abscessus_ATCC_1997 RLPARTRTLRGRAQDPARDARR----RKRRAQRAQTLGSVLKS---AVSF
: .. . :: :
MSMEG_3579|M.smegmatis_MC2_155 LIAVGVGMIMAYVWGANVGGLFTALGVTSIVLGLALQNAVGQIISGLLLL
TH_2299|M.thermoresistible__bu LIAVGLALILAYIWGANVGGLFTALGVSSIVLGLALQNAVGQIVSGLLVL
Mb2460c|M.bovis_AF2122/97 LIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFML
Rv2434c|M.tuberculosis_H37Rv LIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFML
MMAR_3756|M.marinum_M LIGIGLAMILSYVWGVRVGGIFTALGVTSVVIGLMLQNSVGQIVSGLFML
MUL_3699|M.ulcerans_Agy99 LIGIGLAMILSYVWGVRVGGIFTALGVTSVVIGLMLQNSVGQIVSGLFML
MAV_3202|M.avium_104 LIGVGLAVIFSYVWGVRVGGLFTALGVTSVVIGLMLQNSVGQIVSGLFML
Mflv_1046|M.gilvum_PYR-GCK MLGAAAALMTFPAFSDIGKTVFASAGVLTVVAGLAAQTSLGSVFAGIQIA
Mvan_5784|M.vanbaalenii_PYR-1 VLGAAAALMTFPSFSDIGKTLFASAGVLTVVAGLAAQTSLGSVFAGIQIA
MAB_1411|M.abscessus_ATCC_1997 LVLVWVILQSLAILGVNVAPFIASAGIVGVALGFGAQNLVRDFITGIFML
:: : . .::: *: :. *: *. : ...:*: :
MSMEG_3579|M.smegmatis_MC2_155 FEQPFQLGDWLDTPSARGRVVEVNWRATHIDTGGG-LQIMPNSVLAGASF
TH_2299|M.thermoresistible__bu FEQPFQIGDWVDTPSARGKVVEVNWRATHIDTGGG-LRVIPNSELADASF
Mb2460c|M.bovis_AF2122/97 FEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAF
Rv2434c|M.tuberculosis_H37Rv FEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAF
MMAR_3756|M.marinum_M FEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTG-LRITPNSVLATTAF
MUL_3699|M.ulcerans_Agy99 FEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTG-LRITPNSVLATTAF
MAV_3202|M.avium_104 FEQPFRIGDWLDTPAARGRIVEANWRSVHIQTGHG-LQITPNSVLATTSF
Mflv_1046|M.gilvum_PYR-GCK FSDAIRVGDVVVLEEEWGRIEEITLTYVVVHLWDERRLVLPCTYFTSTPF
Mvan_5784|M.vanbaalenii_PYR-1 FSDAIRVGDIVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTYFTDTPF
MAB_1411|M.abscessus_ATCC_1997 FEDQYGVGDVVDVGDAVGTVESVGLRITTVRDLQGTLWYVRNG--GIARV
*.: :.* : * : . . : : .
MSMEG_3579|M.smegmatis_MC2_155 TNLSRPEAAHSLSVTTTFGVSDSPDAVCALLTRVATQLPQRRAGAAPKAI
TH_2299|M.thermoresistible__bu TNLSRPPGTHTITVPTVFAGGDAPDQVCAMLTRVAANLPQLLPGAEPSAA
Mb2460c|M.bovis_AF2122/97 TNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATI
Rv2434c|M.tuberculosis_H37Rv TNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATI
MMAR_3756|M.marinum_M TNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATV
MUL_3699|M.ulcerans_Agy99 TNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATV
MAV_3202|M.avium_104 TNLSRPPGGHQLTLTATFSETDPPDRVCALLRRVADALPQRRPDAVAAAV
Mflv_1046|M.gilvum_PYR-GCK QNWTRNATELLGTAELDVDFTVPFDQMRAELDRLLRANPLWDG-------
Mvan_5784|M.vanbaalenii_PYR-1 QNWTRNATELLGTAELDVDFTVPFDAMRAELDRMLHANDKWDG-------
MAB_1411|M.abscessus_ATCC_1997 GNFSQDYAVAFLQIPLSYSADVDLACTIALEA------------------
* :: *
MSMEG_3579|M.smegmatis_MC2_155 PLGAGEYKTSIPLRTPADDSAARAVFLRWLWYAARRAELHLDGETDDFST
TH_2299|M.thermoresistible__bu PAGRGEYRTSIPLRTPADDATARSTFLRWVWYAARRAGLHLDRSTDDFVT
Mb2460c|M.bovis_AF2122/97 ARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFST
Rv2434c|M.tuberculosis_H37Rv ARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFST
MMAR_3756|M.marinum_M ALGGAEYRTTVRIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDTFST
MUL_3699|M.ulcerans_Agy99 ALGGAEYRTTVRIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDSYST
MAV_3202|M.avium_104 PAGGGEYHVTIGLTSPADDSAAQATLLRWLWYGARREGLRLDGAEDDIST
Mflv_1046|M.gilvum_PYR-GCK -------RVGVLQVTDAVEGRVRVRMLVSASNAGQLFDLRCDVREGMVAW
Mvan_5784|M.vanbaalenii_PYR-1 -------RVGVLQVTDAVEGLVRVRMLVSAPNAGALFDLRCDIREGMVAW
MAB_1411|M.abscessus_ATCC_1997 ------AREAVAEEALRDDVIGAPEMLGIDGITADAISLRLTVAVRAN--
: : : : :* . *
MSMEG_3579|M.smegmatis_MC2_155 PERLTKAVRQMA-PTLRLSHTEQQEVLNHSALVRFGADEIIQEAGEIPTR
TH_2299|M.thermoresistible__bu TERLTTALAAIA-PALRLSEAEQQDLLPRAGIARYGAGEPIQVAGEVPSH
Mb2460c|M.bovis_AF2122/97 AERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMG
Rv2434c|M.tuberculosis_H37Rv AERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMG
MMAR_3756|M.marinum_M PQRVQDALRAVS-PELKLSLLDQQSLAPYAKVVRYGTDETVQQAGVVPKG
MUL_3699|M.ulcerans_Agy99 PQRVQDALRAVS-PELKLSLLDQQSLAPYAKVVRYGTDETVQQAGVVPKG
MAV_3202|M.avium_104 PERIERALRMVVAPALRLGPPDQQALVSHARIVRYGADEIVEHAGRVPEK
Mflv_1046|M.gilvum_PYR-GCK LQRTN------------PGAMPRTRIEHRTDADTARGDAAVPVPGRS---
Mvan_5784|M.vanbaalenii_PYR-1 LQRTN------------PCALPRKRIEHHNDS-RRHGEATEAPVGRP---
MAB_1411|M.abscessus_ATCC_1997 ------------------AQWAVERELRRRILIAFDENGIRPLYLDG---
MSMEG_3579|M.smegmatis_MC2_155 MSFIVSGRVGVSVAGDGDAVIPVRTLTENDFLGQTALTREGALASAHALT
TH_2299|M.thermoresistible__bu MTFVVRGRVRVVAPLADGSAVEVRIAGPGDFLGQSTLTREPVSTSAYAVD
Mb2460c|M.bovis_AF2122/97 ITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
Rv2434c|M.tuberculosis_H37Rv ITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
MMAR_3756|M.marinum_M MSFIIAGSVRLMVTPADGPAVAVGTLGKGAFLGVTALTRQPNPGGAVALE
MUL_3699|M.ulcerans_Agy99 MSFIIAGSVRLMVTPADGPAVVVGTLGKGVFLGVTALTRQPNPGGAVALE
MAV_3202|M.avium_104 MTFLLAGGVRLTATAPDGSVVAVGGLDEGSFLGVTALTRQPNLADAQAVA
Mflv_1046|M.gilvum_PYR-GCK ------------------------QADSGLFSGSIAADRRNRDLTWAHDA
Mvan_5784|M.vanbaalenii_PYR-1 ------------------------QAESGLFSGSAAAERRGRAMSGAR--
MAB_1411|M.abscessus_ATCC_1997 -------------------------LSSGTVETLEKASR-----------
. . *
MSMEG_3579|M.smegmatis_MC2_155 ETTVLQISREFLEELVAGNPLLLLELSRIIDDRRSAARAALTAD------
TH_2299|M.thermoresistible__bu EVTVVELERTVLEDLVTRKPVLLQDIGRAIEERRLMARRAVTTQR-----
Mb2460c|M.bovis_AF2122/97 EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPA
Rv2434c|M.tuberculosis_H37Rv EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPA
MMAR_3756|M.marinum_M EVTVLDIDREYLERIVMSKPALLQELGRLIDERQMKVRQVTQRERVA---
MUL_3699|M.ulcerans_Agy99 EVTVLDIDREYLERIVMSKPALLQELGRLIDEQQMKVRQVTQRERVA---
MAV_3202|M.avium_104 EVTALEIDREHLVELVTGKPLLLQDLGRTIDERRALVHRAVTAEPTPSRE
Mflv_1046|M.gilvum_PYR-GCK R-------------------------------------------------
Mvan_5784|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1411|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3579|M.smegmatis_MC2_155 -----------
TH_2299|M.thermoresistible__bu -----------
Mb2460c|M.bovis_AF2122/97 AAGEHRGPARR
Rv2434c|M.tuberculosis_H37Rv AAGEHRGPARR
MMAR_3756|M.marinum_M -----------
MUL_3699|M.ulcerans_Agy99 -----------
MAV_3202|M.avium_104 PVS--------
Mflv_1046|M.gilvum_PYR-GCK -----------
Mvan_5784|M.vanbaalenii_PYR-1 -----------
MAB_1411|M.abscessus_ATCC_1997 -----------