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VSAAAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAHPDLTPGPISAMLFRTRAARRHRALAMVRTRA ELIDALQAMIDRYEHPALIRTDPAAIRRRIGYVFPGQGGQRPGMGQLFYESVPAFRAEVDRCAQAFEAQS CGSPRNYLLDKNFQDDGSAGIVQPALFTQMAALAAMWRSFGIAPNVTIGHSQGEVAAAYVSGTITLEDAV RVIGIRAHAADEFAAADYAMAIVAADRETCEDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTE GGTFARVIRVRYPAHTSLIHDGADKLRAAIQDQLQHPSFVDTDIDCLGATLGAPITSELPVGDYWFWNLR NIVRFDKAIAAAVQRDVETFVELAEHPTLQLAIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLA QLAVHDLNYPWECLRAEPDGAQALPLLDFPNTRMNEIRLWLPYDEVLPRRQPPSVSVAPAAPSVPDATAD TTPARLLVEEWVRLSQRSLTPPRVVGIVDPTGACAQLATAMTAAAHQAGATARVVNGENDGTGADVNTLV ILLPETPKLDGRAAAAEVGGFFSNRAWWPGVDTGVTDCWLVTVGGEAATAADGPPDPVHAAASAGFRSIG AEHPGVGFRHLDLPAGATAQDWAHPIVAALHTANEPELAYRDGAFYAKRIVAGEGAVVHGAGACPEHVLI IGGTGNLGLEFCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTRCDVGDPAAVSRLAAQH RSTPADLIIHAAVAYASVEFSDITTDDADNALYAKVVGIGQVLDAFPRTDGCRIVLCSSARATIGGRGQV MYAAANRMLDAMAHRLRAEGLDCVSVQWGQWTVHFDLDASSMAQLAAIGVIPMPPAEAIALGMQRLGRNA IVAAFDFDRARPVLETFGYGPLVSELLSPVSETAAPAEPADLPGRLSNLLAAAIGAERAERIDTSVPMVA LGLDSLQALELRRRVKAEFDHELEVSDLLGGASIADVLAQLGSR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3695 | mbtD | - | 100% (1024) | polyketide synthase MbtD |
M. marinum M | MMAR_1775 | ppsB | 6e-58 | 25.38% (1064) | phenolpthiocerol synthesis type-I polyketide synthase PpsB |
M. marinum M | MMAR_1776 | ppsA | 2e-55 | 24.85% (1010) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2402c | mbtD | 1e-137 | 32.63% (1039) | polyketide synthetase MBTD (polyketide synthase) |
M. gilvum PYR-GCK | Mflv_2695 | - | 1e-136 | 34.86% (1027) | acyl transferase region |
M. tuberculosis H37Rv | Rv2381c | mbtD | 1e-137 | 32.63% (1039) | polyketide synthetase MBTD (polyketide synthase) |
M. leprae Br4923 | MLBr_02356 | - | 3e-53 | 25.14% (1038) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_2119c | - | 0.0 | 54.17% (1008) | putative polyketide synthase MbtD |
M. avium 104 | MAV_2012 | - | 1e-136 | 34.23% (1037) | MbtD protein |
M. smegmatis MC2 155 | MSMEG_4512 | - | 1e-129 | 33.46% (1034) | polyketide synthetase mbtd |
M. thermoresistible (build 8) | TH_3022 | - | 1e-100 | 34.79% (802) | PUTATIVE acyl transferase domain protein |
M. ulcerans Agy99 | MUL_3638 | mbtD | 0.0 | 99.12% (1024) | polyketide synthase MbtD |
M. vanbaalenii PYR-1 | Mvan_3846 | - | 1e-139 | 33.98% (1036) | acyl transferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 MRTAFSRISGMTTQQRAALIEEFTKLSRIAVAEPIAVVGIGCRFPGDVTG MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 PDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGGFVSDI MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 AGFDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGNSRTGV MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 MIGVYFNEYQSMLASSLENVDAYSGTGNAHSITVGRISYLLGLRGPSLAV MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 DTACSSSLVAVHLACQSLRLRETDLVLAGGVSITLRPETQIAISAWGLLS MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 PHGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDLVLAVVRGSAVNQ MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 DGRSNGVTAPNTAAQCDVITDALRSSDVAPESVNYVESHGTGTVLGDPIE MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 FEALAATYGRGESACALGAVKTNLGHLEAAAGIAGFIKTVLAVQRGQIPP MMAR_3695|M.marinum_M -------------------------------------------------- MUL_3638|M.ulcerans_Agy99 -------------------------------------------------- MAB_2119c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_4512|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2402c|M.bovis_AF2122/97 -------------------------------------------------- Rv2381c|M.tuberculosis_H37Rv -------------------------------------------------- TH_3022|M.thermoresistible__bu -------------------------------------------------- Mflv_2695|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2012|M.avium_104 -------------------------------------------------- MLBr_02356|M.leprae_Br4923 NLHFSQWNPAIDAASTRFFVPTENSSWPISDGQAGPRRAAVSSFGLGGTN MMAR_3695|M.marinum_M -----------MSAAAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAH MUL_3638|M.ulcerans_Agy99 -----------MSAAAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAH MAB_2119c|M.abscessus_ATCC_199 ----------------------------------MLRREASALLAYVADH MSMEG_4512|M.smegmatis_MC2_155 ------------MMTDGTLCDHRVPVVLSAHAEDLIAHDATAILRYLDGR Mvan_3846|M.vanbaalenii_PYR-1 -------------MSAGRLPDGRVAVPLSAHHEALVSATARDILGHLQ-R Mb2402c|M.bovis_AF2122/97 -------------MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERF Rv2381c|M.tuberculosis_H37Rv -------------MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERF TH_3022|M.thermoresistible__bu ---------MTPITRANSWPDGRIPVLLSAHAEDLLRADARALLDYLDRE Mflv_2695|M.gilvum_PYR-GCK -----------------MLPDGRIPVLLSAHAEELIGEDARRLLGFLD-- MAV_2012|M.avium_104 ------------MMPTHGLPDGRIPVLLSSHDPELIRRDAAAILEYLDRI MLBr_02356|M.leprae_Br4923 AHVVIEQGPELTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWVEGP : * : : MMAR_3695|M.marinum_M --PDLTPGPISAMLFRTRAARRHRALAMVRTRAELIDALQAMIDRYEHPA MUL_3638|M.ulcerans_Agy99 --PDLTPGPISAMLFRTRAARRHRALAMVRTRAELIDALQAMIDRYEHPA MAB_2119c|M.abscessus_ATCC_199 --PRIAPNRIAGMIFRTRVARRYRALATVENHDQLVAALRTVVAGTEHPL MSMEG_4512|M.smegmatis_MC2_155 --TDTAPSDVAYTLLRTRRLRRHRAVIRAGGLDELTAGLRALADGDDHPL Mvan_3846|M.vanbaalenii_PYR-1 --NPSEPGQVAAQLVRTRRLRRHRAIVRAGDRDELAAGLQAVADDRDHPL Mb2402c|M.bovis_AF2122/97 --PATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPL Rv2381c|M.tuberculosis_H37Rv --PATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPL TH_3022|M.thermoresistible__bu --PAAAVXXXX------------RAVIRAADRTELADGLRAVADGAEHRL Mflv_2695|M.gilvum_PYR-GCK --SAPEVDAVAATLLRVRRRNRHRAVVRAADRSELADALSALAAGQEHPL MAV_2012|M.avium_104 GESTEATGAVAATLLRLRRVRRHRALLRAADRAELAAGLAAIARGEEHAL MLBr_02356|M.leprae_Br4923 G-AEVALADVAHTLNHHRSRHAKFGTVVARDRIQAVAGLRALAAGKQAPG . . : .* :: : MMAR_3695|M.marinum_M LIRTDPA--AIRRRIGYVFPGQGGQRPGMGQLFYESVPAFRAEVDRCAQA MUL_3638|M.ulcerans_Agy99 LIRTDPA--AIRRRIGYVFPGQGGQRPGMGQLFYESVPAFRAEVDRCAQA MAB_2119c|M.abscessus_ATCC_199 VVRNSEP--ATARRHGFVFPGQGGQRPGMGRLFYDAFPSFRAEVERCADL MSMEG_4512|M.smegmatis_MC2_155 VTRAAAPQPGSRRRVAFVFPGQGSQWPSMGVEAYR-LDDYRAEVDRCAAA Mvan_3846|M.vanbaalenii_PYR-1 VARSAG-RAGAR--TAFVFPGQGSQWPGMGGEAYRLLPVYRAEADRLTEA Mb2402c|M.bovis_AF2122/97 IARSSL---GSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA Rv2381c|M.tuberculosis_H37Rv IARSSL---GSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA TH_3022|M.thermoresistible__bu VARSDH---STAPRLAFVFPGQGSQWPGMGAAAYRQFAEYRAGVDACAAA Mflv_2695|M.gilvum_PYR-GCK VSRSAEP---DAHRRAFVYPGQGNQWPAMGAEAYRTLRDYRQAADVCAAA MAV_2012|M.avium_104 ITRSAR---TTPPRIAFVFPGQGNQWQAMGADAYRRLPAYREAADRCAQA MLBr_02356|M.leprae_Br4923 VVGQQDG--TPGSGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPV : :*:.*:*.: .** : . MMAR_3695|M.marinum_M FEAQSCGSPRNYLLDKNFQ----DDGSAGIVQPALFTQMAALAAMWRSFG MUL_3638|M.ulcerans_Agy99 FEAQACGSPRNYLLDKNFQ----DDGSAGIVQPALFTQMAALAAMWRSFD MAB_2119c|M.abscessus_ATCC_199 FDKQFGRSPLSYLLDDQLP----TNDSATVVQPALFTQMVGLAALWRTVG MSMEG_4512|M.smegmatis_MC2_155 FEAAGAASPLDYLLAHPDSGVSTNDFSQVQIQGAQFVHGVALARVWRSHG Mvan_3846|M.vanbaalenii_PYR-1 FLAAGLTSPLPFLTADTDG----EPVSQYDLQAAQFVHSVALAAVWRSCG Mb2402c|M.bovis_AF2122/97 FAAAGVDSPLPYLIAPPGT-DERQAFCEIEIEGAQFVHAVALAEVWRSCG Rv2381c|M.tuberculosis_H37Rv FAAAGVDSPLPYLIAPPGT-DERQAFCEIEIEGAQFVHAVALAEVWRSCG TH_3022|M.thermoresistible__bu FTAAGAPAPLRYLTTP----DDPESFCETEVEGAQFTHAVALARMWRHHG Mflv_2695|M.gilvum_PYR-GCK FTAAGAPSPLRYLTDAAAV-----TGSQVEAQAAQFTHAVALTAVWRAHG MAV_2012|M.avium_104 FVAAGFPSPLPYLVSPDEQ-----SWTRPEIQGAQFTHAVALAEAWRCFG MLBr_02356|M.leprae_Br4923 FVVHAGFSLHDVLANGKEL------VGIEQIQLGLIGMQLTLTELWRSYG * : * : . : *: ** . MMAR_3695|M.marinum_M IAPNVTIGHSQGEVAAAYVSGTITLEDAVRVIGIRAHAADEFAAADYAMA MUL_3638|M.ulcerans_Agy99 IPPNVTIGHSQGEVAAAYVSGTITLEDAVRVIGIRAHAADEFAAADYAMA MAB_2119c|M.abscessus_ATCC_199 VTPRAVVGHSQGEIAGAYVSGVMSLDDAVTVVGTRAGIADEFPADDYAMA MSMEG_4512|M.smegmatis_MC2_155 VVPDITVGHSLGEIGAAYVAGAITLPEAVAIVIARATVLDRLTGP-YRVA Mvan_3846|M.vanbaalenii_PYR-1 IVPDLTVGHSLGEVAAAYVAETVTLVDAVTVLAARAAAIEAIPGD-NGVA Mb2402c|M.bovis_AF2122/97 VLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGR-YAVA Rv2381c|M.tuberculosis_H37Rv VLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGR-YAVA TH_3022|M.thermoresistible__bu VLPDITVGHSLGEVGAAYIAGAITLADAVSVVIARAGVVDRLPGR-YAVA Mflv_2695|M.gilvum_PYR-GCK VAPDMTVGHSLGEVAAAHVAGAITLAEAAAVVIARATVLEGLADG-YRMA MAV_2012|M.avium_104 VLPEMAIGHSLGEVAAAYVAEAISLPDAVALVVARATVVDRLTGR-YAMA MLBr_02356|M.leprae_Br4923 VQPDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQ-GGMA : * .:*** **:..* :: :: :. : *: :. :* MMAR_3695|M.marinum_M IVAADRETCEDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTEG MUL_3638|M.ulcerans_Agy99 IVAADREACEDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTEG MAB_2119c|M.abscessus_ATCC_199 VIATDRDTCEELLARNSGWAELSVINSPSMVGISGQRETVHQIVEHLIED MSMEG_4512|M.smegmatis_MC2_155 VLGITPEQAAEVIAETPGWLELSVVNSPSSVAVSGETGAVAAAVRTVAAR Mvan_3846|M.vanbaalenii_PYR-1 VLGVDATEAAELIAATGGWLELSAVNAQNSVAVSGERSAVAAIAAAARAR Mb2402c|M.bovis_AF2122/97 ALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSS Rv2381c|M.tuberculosis_H37Rv ALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSS TH_3022|M.thermoresistible__bu VLGVDADAARDVIASTPGWLELSVVNAPSSVAVSGDRDAVSAAVARVREQ Mflv_2695|M.gilvum_PYR-GCK VLGLTPEDAQSLIESVPGWLELAVVNAASSVGVSGERDAVDALLAQASSR MAV_2012|M.avium_104 VLGAGAADAESLLATTPGWVEVSAVNGPASTVVAGDHDAVAAAVRLAQQR MLBr_02356|M.leprae_Br4923 LLELDAVETEALIVDYS-QVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQ : :: :: *. . ::* : MMAR_3695|M.marinum_M GTFARVIRVRYPAHTSLIHDGADKLRAAIQDQLQHPSFVDTDIDCLGATL MUL_3638|M.ulcerans_Agy99 GTFARVIRVRYPAHTSLIHDGADKLRAAIQDQLQHPSFVDTDIDCLGATL MAB_2119c|M.abscessus_ATCC_199 GVFARVIPVRYPAHTSMIASIGAQIRHALTENLDAGEFTVSEIDCIGATL MSMEG_4512|M.smegmatis_MC2_155 GAFAKEIEMWFPAHTTALDG----VRADLDALLPAGRFAETPVQFIGSAT Mvan_3846|M.vanbaalenii_PYR-1 GRFAKELAMSFPAHTTAMET----QREQLVRRLPTSVFADSPVQFVGSAT Mb2402c|M.bovis_AF2122/97 GHFARGITVGFPVHTSVLES----LRDELCEQLPDSEFMEAPVQFIGGTT Rv2381c|M.tuberculosis_H37Rv GHFARGITVGFPVHTSVLES----LRDELCEQLPDSEFMEAPVQFIGGTT TH_3022|M.thermoresistible__bu GRFAREITVGFPVHTSILEP----LRDDLLRNLPQAEFADSPVQFIGAAT Mflv_2695|M.gilvum_PYR-GCK GVFARSVTMAFPAHTSLLDG----LRADFVRLLAPARFQQTAIPFLGSAT MAV_2012|M.avium_104 EIFAHQLFVDYPGHTSALRP----LRAALAELTPQSAFRDSPIRFIGSTR MLBr_02356|M.leprae_Br4923 NRFASRVNIEVAPHNPAMDA----LQPQMRSELADVAPRTPTIPILSTTY ** : : . *.. : : : . : :. : MMAR_3695|M.marinum_M GAPITSELPVGDYWFWNLRNIVRFDKAIAAAVQRDVETFVELAEHPTLQL MUL_3638|M.ulcerans_Agy99 GAPITSELPVGDYCFWNLRNIVRFDKAIAAAVQRDVETFVELAEHPTLQL MAB_2119c|M.abscessus_ATCC_199 GTAISPEMPVDQYWFWNLRNAVRFDRAVATAAAAHVDTFVELAEHPTLQL MSMEG_4512|M.smegmatis_MC2_155 ADVVTTGTDFADYWYTNLRTTVRFDQAVARAARRGARIFVELSAHPALLF Mvan_3846|M.vanbaalenii_PYR-1 GQLVRAGTEFGAYWYANLRNTIRFDQAVQTAIGLGAGVYVELSAHPSLLF Mb2402c|M.bovis_AF2122/97 GDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLF Rv2381c|M.tuberculosis_H37Rv GDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLF TH_3022|M.thermoresistible__bu GDVVPAGTGFGPYWYGNLRHLVRFDRAFQTALRCGARTFVELSAHPSLLF Mflv_2695|M.gilvum_PYR-GCK GEAVPPETDFADYWFANLRNTVRFDRAAAAAVRAGANLFVEMSAHPALLF MAV_2012|M.avium_104 GAEVAATTDYASYWYENLCSTVRFDLAVQCARSCGADAFVELSAHPSLLY MLBr_02356|M.leprae_Br4923 ADLGSCPVFDAQHWATNMRNPVHFQQAIMTAG-TDHRTFIEISAHPLLTQ . : *: ::*: * * ::*:: ** * MMAR_3695|M.marinum_M AIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLAQLAVHDLNYPW MUL_3638|M.ulcerans_Agy99 AIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLAQLAVHDLNYPW MAB_2119c|M.abscessus_ATCC_199 ALRENLAALGSE---RTACVVGTSHRNATDLGEFTANLAKIAVHDLDYNW MSMEG_4512|M.smegmatis_MC2_155 NMGELLEST------RGVVLVGSGRRDEPLPERLADNVITVALADAGYRW Mvan_3846|M.vanbaalenii_PYR-1 AVEDGIERVG----AAAAVLVGSGHRDESVPDRLSANIVTAAAADPAYRW Mb2402c|M.bovis_AF2122/97 AIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYPW Rv2381c|M.tuberculosis_H37Rv AIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYPW TH_3022|M.thermoresistible__bu AMSELLG-------DTPATLLGSTRRDEPIAETFTANLAAAAVSDPGYDW Mflv_2695|M.gilvum_PYR-GCK SLGQSAG---------DALTVGSGRRDAPLVETLSAGIATVAAHDAEFPW MAV_2012|M.avium_104 PLSGIID-------DESAVIVGSGHRDRPITESLSASMAAVATADPGYRW MLBr_02356|M.leprae_Br4923 AITDTLHG-------TRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTP : :*: .* : .: . . MMAR_3695|M.marinum_M ECLRAEPDGAQA--LPLLDFPNTRMNEIRLWLPYDEVLPRRQPP--SVSV MUL_3638|M.ulcerans_Agy99 ECLRAEPDGAQA--LPMLDFPNTRMNEIRLWLPYDEVLPRRQPP--SVSV MAB_2119c|M.abscessus_ATCC_199 DALRTEAPDRVS--LPLRDFPNVQNNDIPLWLSYRADTSGVAVPKQPIVT MSMEG_4512|M.smegmatis_MC2_155 RDQLGDCHA------VLPDFPFAPMRAEHLWAQPDPLPP----------- Mvan_3846|M.vanbaalenii_PYR-1 GDLLTGEPE------PLFGFPGAPMRAEHLWAEPEPLPV----------- Mb2402c|M.bovis_AF2122/97 GDLGGDPLDGD---VDLSGFPNAPMRAVPMWAHPEPLPP----------- Rv2381c|M.tuberculosis_H37Rv GDLGGDPLDGD---VDLSGFPNAPMRAVPMWAHPEPLPP----------- TH_3022|M.thermoresistible__bu RAVTPAGPD------RLTGFPNAPMRAIPMWATAAPRRIGRAGG------ Mflv_2695|M.gilvum_PYR-GCK HDVIDTTRP------ALRGFPNAPMRSVHLWALPQPLPA----------- MAV_2012|M.avium_104 SETVPTRNQ-----PALHGFPNAPMRATHLWAAPDRVTEAAP-------- MLBr_02356|M.leprae_Br4923 HPAEPHVTIPSTPWQHTRHWITTPLASTTALQHLDRNRVTTHATG-IGNT : . MMAR_3695|M.marinum_M APAAPSVPDATADTTPARLLVEEWVRLSQ----RSLTPPRVVGIVDPTGA MUL_3638|M.ulcerans_Agy99 APAAPSVPDATADTTPARLLVEEWVRLSQ----RSLTPPRVVGIVDPTGA MAB_2119c|M.abscessus_ATCC_199 PEAERRVEMGNDSRAYPRLLREAWAKVTR----RSMMPPRSYAFIDGTGD MSMEG_4512|M.smegmatis_MC2_155 -------------VTGLTVAAEQWHQVAV--PEVSG--HHRIAVVGLDS- Mvan_3846|M.vanbaalenii_PYR-1 -------------APGLTVTTETWRQRRP--RRVSAKVSRRVAVIESGS- Mb2402c|M.bovis_AF2122/97 -------------VSGLTIAVERWERMVP--STPVAGRHRHLAVLDLGA- Rv2381c|M.tuberculosis_H37Rv -------------VSGLTIAVERWERMVP--STPVAGRHRHLAVLDLGA- TH_3022|M.thermoresistible__bu --------VRGEEAPGLRIAAEVWEPVAAQPGPASAATPVPVALLELGD- Mflv_2695|M.gilvum_PYR-GCK -------------PPSLTLATEAWEPHRP---AERGLALRRTAVLDLAGP MAV_2012|M.avium_104 -------------RPRLTVAVEDWRHTTS-------PTTPTAADLGFAG- MLBr_02356|M.leprae_Br4923 ELDDWIYQLDWPTRPLTSEPGATWASSGSWLVVSDAGLSDELARLVVLAD . * . : MMAR_3695|M.marinum_M CAQLATAMTAAAHQAGATARVVNGENDGTGADVNTLVILLPETPKLDGRA MUL_3638|M.ulcerans_Agy99 CAQLATAMTAAAHQAGATARVVNGENDGTGADVNTLVILLPETPKLDGRA MAB_2119c|M.abscessus_ATCC_199 AGALVEALRDSAPNFGSSARIVTGTDESGIGDADTVVIVLPSPALLDDHE MSMEG_4512|M.smegmatis_MC2_155 ECAVAGHLRDAAERI-------EGVEVVAPAAADTLLVVAPMISENDPVL Mvan_3846|M.vanbaalenii_PYR-1 GTAISRSLRQAIDRR-------ADLSVAGAADADLAIVVAPTFAGADAAG Mb2402c|M.bovis_AF2122/97 HRALAQTLCAAIDSH-------PDTELSAARDAELILVIAPDFEHTDAVR Rv2381c|M.tuberculosis_H37Rv HRALAQTLCAAIDSH-------PDTELSAARDAELILVIAPDFEHTDAVR TH_3022|M.thermoresistible__bu TGRLGGWLRELLGNR-------PDVVLVGPEAAEVAVVAAPESDTAAPEA Mflv_2695|M.gilvum_PYR-GCK RGGLGDLLRDAVDHH-------PGMVSTPVHDADLVLAVAPNLGDPDVRE MAV_2012|M.avium_104 AHPMTRRLADAAAAQ-------GGCRVVAPGEAEIVAIVAPELDQLDAVA MLBr_02356|M.leprae_Br4923 PASRVEYLAPSALDHDVS---TLHDLHNALRGVDNVLYAPSVSTESVDPV : .: . MMAR_3695|M.marinum_M AAAEVGGFFSN--RAWWPGVDTGVTDCWLVTVGGEAATAADGPPDPVHAA MUL_3638|M.ulcerans_Agy99 AAAEVGGFFSN--RAWWPGVDTGVTDCWLVTVGGEAATAADGPPDPVHAA MAB_2119c|M.abscessus_ATCC_199 AADAVARFFGN--RTWWPRLSSTVTGCWLVTVGGEQAIADDGPAHPVHAA MSMEG_4512|M.smegmatis_MC2_155 AGEELGRRIDEGLLRYPDLLTETTRDVWLVTGRGEHVPVDRDGSLPVGAA Mvan_3846|M.vanbaalenii_PYR-1 CVNELSGAIDTGLLGYADTFGPRCRDVWLVTVGAENVTAEDPAPDLGQAG Mb2402c|M.bovis_AF2122/97 AAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAA Rv2381c|M.tuberculosis_H37Rv AAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAA TH_3022|M.thermoresistible__bu GVAAITELVRAGGLRYPAAPGPHCRDVWLVTVGAEQVHPDDPVAPV-PAA Mflv_2695|M.gilvum_PYR-GCK SVAALTALIDDGLLRYPDDVGTDCRDLWLVTTAAEQLTG-DPTPRPAQAA MAV_2012|M.avium_104 AVEQIGAREDAGLPDYRGLIGPRCRAVWLLTVRAEHVDGDDDQACVAQAA MLBr_02356|M.leprae_Br4923 DPESGYRLFHAVRRLAAAMVAGTSKPKLVVVTRNAQPVAVGERANPAHAV ::. . * MMAR_3695|M.marinum_M ASAGFRSIGAEHPGVGFRHLDLPAG--------ATAQDWAHPIVAALHTA MUL_3638|M.ulcerans_Agy99 ASAGFRSIGAEHPDVGFRHLDLPAG--------ATAQDWAHPIVAALHTA MAB_2119c|M.abscessus_ATCC_199 IAAGFRCMGTEHPGIAFRHLDLTSD--------IASPDKADNILAALQSA MSMEG_4512|M.smegmatis_MC2_155 VAAMHRSIAFEHPDQNFRQLDVPMGL--------DTEAAVTAVAAMVTGT Mvan_3846|M.vanbaalenii_PYR-1 VAALHRCIGFEHPDQSFHHLDLPAG----------ATDALGAVDVMVDGA Mb2402c|M.bovis_AF2122/97 LAAMHRSIGFEHPEQTFSHLDLPS-------WDLDPVLGVSVITAVLRGF Rv2381c|M.tuberculosis_H37Rv LAAMHRSIGFEHPEQTFSHLDLPS-------WDLDPVLGVSVITAVLRGF TH_3022|M.thermoresistible__bu VAAMHRSLGLENPQIPFHHLDLEQGVGSDTARDTDPAVAALLMDAVLSAT Mflv_2695|M.gilvum_PYR-GCK LAAMHRSIGFEYPDRAFRHLDLPPVV-------LDEAAASAALDAVLGGG MAV_2012|M.avium_104 LAAMHRSIGFEFPDQAFGHVDLPHR-------DVDAATAYAIIEVLLAEP MLBr_02356|M.leprae_Br4923 LWGFGRTLALEHPEIWGSVIDLDASMP----PELAARCILDEVASQDEKD . * :. * * :*: : MMAR_3695|M.marinum_M NEPELAYRDGAF-------YAKRIVAG-EGAVVHGAG-ACPEHVLIIGGT MUL_3638|M.ulcerans_Agy99 NEPELAYRDGAF-------YAKRIVAG-EGAVVHGAG-ACPEHVLIIGGT MAB_2119c|M.abscessus_ATCC_199 GESELALRADGM-------YAKRVLDIDQDGDESSRV-VAPAHVVITGGT MSMEG_4512|M.smegmatis_MC2_155 T--DLALRCDVADGPGTTLWRRGMRDASAAAAPWP--TGVLDDVVITGGT Mvan_3846|M.vanbaalenii_PYR-1 G--ELALRRDGQ------VYERTLGDDTSTAPPWDLSSGTLDNVVITGGS Mb2402c|M.bovis_AF2122/97 G--ETALRGSVN---GYTLFERTLADAPAVPNWSLDS-GVLDDVVVTGGA Rv2381c|M.tuberculosis_H37Rv G--ETALRGSVN---GYTLFERTLADAPAVPNWSLDS-GVLDDVVVTGGA TH_3022|M.thermoresistible__bu GGGGLAIRTTGA---GAVLYRRGLRDVPAPP--PLDRPGLLDEVVITGGA Mflv_2695|M.gilvum_PYR-GCK D--DLALRDIDG---MPAVFARTEHETVTTPESWADDPGALDHVVITGGS MAV_2012|M.avium_104 A--EVALRGEQS----PRRHVRTFRAHHESADRPLDD-AALEHVVITGGS MLBr_02356|M.leprae_Br4923 REDQVVYRACLR------RAPRLQRRTASAVSSVKLSSGQDTTQLVIGAT . * : :: *.: MMAR_3695|M.marinum_M GNLGLEFCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTR MUL_3638|M.ulcerans_Agy99 GNLGLESCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTR MAB_2119c|M.abscessus_ATCC_199 GKLGQEFCEHYARMGTRQITLISRSGETDAVTGRLDAIRRSTGAKVRALP MSMEG_4512|M.smegmatis_MC2_155 GAVGLQFARRLAALGARRIVLLSRNG---IEGNRVDEL--PLGVEIVAPR Mvan_3846|M.vanbaalenii_PYR-1 GAIGLSFARFLAARGARRIVLLSRRG---AGPAPLDN----LGAEIIAPA Mb2402c|M.bovis_AF2122/97 GAIGMHYARYLAEHGARRIVLLSRRA---ADQATVAMLRKQHGTVIVSPP Rv2381c|M.tuberculosis_H37Rv GAIGMHYARYLAEHGARRIVLLSRRA---ADQATVAMLRKQHGTVIVSPP TH_3022|M.thermoresistible__bu GAIGLHYARQLARRGAKRIVLLSRRP---VDPAELAALAAPTGAEVLSVS Mflv_2695|M.gilvum_PYR-GCK GTVGQHYARHLAERGARRITLLSRHG---AKGS------AAGGPGVQTVC MAV_2012|M.avium_104 GAIGLHYARYCLQRGARNLTLLSRNG---IEAAVLRELTGSHDARVSAPR MLBr_02356|M.leprae_Br4923 GNIGPHLIRQLAAMGATTIVAVSRNP--STRLLELDKNLAATGTNLISVA * :* *: :. :** : MMAR_3695|M.marinum_M CDVGDPAAVS--------------------------------------RL MUL_3638|M.ulcerans_Agy99 CDVGDPAAVS--------------------------------------RL MAB_2119c|M.abscessus_ATCC_199 CDVTDTAAVT--------------------------------------AL MSMEG_4512|M.smegmatis_MC2_155 CDLTDIPRVR--------------------------------------DV Mvan_3846|M.vanbaalenii_PYR-1 CDLRDPRQLA--------------------------------------AT Mb2402c|M.bovis_AF2122/97 CDITDPTQLS--------------------------------------AI Rv2381c|M.tuberculosis_H37Rv CDITDPTQLS--------------------------------------AI TH_3022|M.thermoresistible__bu CDLTDPDAVXXXXVRAVLTAAERAHRHGGDPREVLWQAWHRSGLQRRWLA Mflv_2695|M.gilvum_PYR-GCK CDVTDPVALA--------------------------------------VA MAV_2012|M.avium_104 CDITDRAAVT--------------------------------------EA MLBr_02356|M.leprae_Br4923 ADATDPTAMT--------------------------------------AL .* * : MMAR_3695|M.marinum_M AAQHRSTP------------------ADLIIHAAVAYASV---------- MUL_3638|M.ulcerans_Agy99 AAQHRSTP------------------ADLIIHAAVAYASV---------- MAB_2119c|M.abscessus_ATCC_199 ADQLRDTP------------------ADLIVHAAVDYSDT---------- MSMEG_4512|M.smegmatis_MC2_155 AAEFGGQG------------------ASLIVHAAATATIA---------- Mvan_3846|M.vanbaalenii_PYR-1 VAEFAGGP------------------ASLIIHAAGTATFA---------- Mb2402c|M.bovis_AF2122/97 AAEYGGVG------------------ASLIVHAAGSVISG---------- Rv2381c|M.tuberculosis_H37Rv AAEYGGVG------------------ASLIVHAAGSVISG---------- TH_3022|M.thermoresistible__bu ASERGGVAGVQADRDLDAVTAFFDAAEQYVARTAGATLRGLIDHLTTLGP Mflv_2695|M.gilvum_PYR-GCK AAEFGGDG------------------ATLVIHAAGTAQFA---------- MAV_2012|M.avium_104 AARYAGSG------------------ATLLIHTAGIAQAR---------- MLBr_02356|M.leprae_Br4923 FDRFGVDLP-----------------PLEGIYLAAFAGRP---------V . * MMAR_3695|M.marinum_M EFSDITTDDADNALYAK-------------------------------VV MUL_3638|M.ulcerans_Agy99 EFSDITTDDADNALYAK-------------------------------VV MAB_2119c|M.abscessus_ATCC_199 PLSEVTTNKFQDALRAK-------------------------------VI MSMEG_4512|M.smegmatis_MC2_155 AGSALTGAAAQATFTAK-------------------------------LA Mvan_3846|M.vanbaalenii_PYR-1 NRADITGAALADMAGAK-------------------------------II Mb2402c|M.bovis_AF2122/97 TAPGVTSAAVVDNFAAK-------------------------------VL Rv2381c|M.tuberculosis_H37Rv TAPGVTSAAVVDNFAAK-------------------------------VL TH_3022|M.thermoresistible__bu AAPARDQSARRDAVAVLSAHAALDREWDLVVIAGLQDGLWPNTVPRGGVL Mflv_2695|M.gilvum_PYR-GCK EHDTLSAAAFADTAAAK-------------------------------VE MAV_2012|M.avium_104 SRTDLTGADVAAVCAAK-------------------------------VR MLBr_02356|M.leprae_Br4923 LLSDMTDNDVVAMFRPK--------------------------------L MMAR_3695|M.marinum_M GIGQVLDAFP---------------RTDGCRIVLCSSARATIGGRGQVMY MUL_3638|M.ulcerans_Agy99 GIGQVLDAFP---------------RTDGCRIVLCSSARATIGGRGQVMY MAB_2119c|M.abscessus_ATCC_199 GISNVLDTVP---------------RTDSCRVMLCSSLAATIGGKGQLMY MSMEG_4512|M.smegmatis_MC2_155 GIENVLAAWP---------------VRPDARILLCSSVSGLWGGHGHAAY Mvan_3846|M.vanbaalenii_PYR-1 GLEALTRTWP---------------IRDDARILLCSSVTGVWGGKGVGGY Mb2402c|M.bovis_AF2122/97 GLAQMIELWP---------------LRPDVRTLLCSSVMGVWGGHGVVAY Rv2381c|M.tuberculosis_H37Rv GLAQMIELWP---------------LRPDVRTLLCSSVMGVWGGHGVVAY TH_3022|M.thermoresistible__bu ATQQLVDVLDGVADGSDPVVSRRAPLLAEERRLLIAAMGRARSRLLVTAV Mflv_2695|M.gilvum_PYR-GCK GLFRIAEAWP---------------RRPGARMLVCSSVSGLWGGRGHAAY MAV_2012|M.avium_104 GLALMADVWP---------------LRPDCRILACSSVFGVWGGYHHAAY MLBr_02356|M.leprae_Br4923 DVASLLHRLS--------------LKQPVKYFLLFSSISGLIGSRWLAHY : : :: . MMAR_3695|M.marinum_M AAAN----RMLDAMAHRLRAEGLDCVSVQWG------------------- MUL_3638|M.ulcerans_Agy99 AAAN----RMLDAMAHRLRAEGLDCVSVQWG------------------- MAB_2119c|M.abscessus_ATCC_199 AAGN----RMLDVLASTRRASGLDCTSIQWG------------------- MSMEG_4512|M.smegmatis_MC2_155 AAAN----RLLDVMAERLRSEGRRCTAVRWG------------------- Mvan_3846|M.vanbaalenii_PYR-1 AAAN----RMLDVMAARLGADGRNCTAVRFG------------------- Mb2402c|M.bovis_AF2122/97 SAAN----RLLDVMAAQLRAQGRHCVAVKWG------------------- Rv2381c|M.tuberculosis_H37Rv SAAN----RLLDVMAAQLRAQGRHCVAVKWG------------------- TH_3022|M.thermoresistible__bu DSDDGDESLLPSPFCAELAALATEPEAATPAPLPAPRVLTAAALVGRLRS Mflv_2695|M.gilvum_PYR-GCK AAAN----RLVDVTAAQMRAEGIRCAAVRFG------------------- MAV_2012|M.avium_104 AASN----RMLDVLATQLRARGLDCTAIRWG------------------- MLBr_02356|M.leprae_Br4923 TATS----AFLDILGYARRLVGLPATVVAWG------------------- : . : . . . MMAR_3695|M.marinum_M -QWTVH-------FDLDASSMAQLAAIGVIPMPPAEAIALGMQRLG---- MUL_3638|M.ulcerans_Agy99 -QWTVH-------FDLDASSMAQLAAIGVIPMPPAEAIALGMQRLG---- MAB_2119c|M.abscessus_ATCC_199 -QWTVH-------LDLGDAGIAKLAAAGVHPMRPADALAVGMGHHH---- MSMEG_4512|M.smegmatis_MC2_155 -LWPG-------AGIIDADEITRVERSGLRAMAPDRAVDTALQDFA---- Mvan_3846|M.vanbaalenii_PYR-1 -LWEG-------SGIVDAAEIARVERTGLRQMKPELAVEASLCDFP---- Mb2402c|M.bovis_AF2122/97 -LWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF----- Rv2381c|M.tuberculosis_H37Rv -LWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF----- TH_3022|M.thermoresistible__bu VVCAAPDTVDDEVRAGAATQLARLAAAGVPGADPAQWYAMTPLSTGEPLW Mflv_2695|M.gilvum_PYR-GCK -LFGT--------GIVDEESVNLIGRSGLVPLDPDDAVAASLRDLP---- MAV_2012|M.avium_104 -LWQD-------AGVVAGSEIARTERSGLVAMDPRRALQASLHRYE---- MLBr_02356|M.leprae_Br4923 -LWKS-------LADAQQDATQVSAESGLQPMTDDVAIGALPLVMSP--- *: MMAR_3695|M.marinum_M ----------------------------------------RNAIVAAFDF MUL_3638|M.ulcerans_Agy99 ----------------------------------------RNAIVAAFNF MAB_2119c|M.abscessus_ATCC_199 ----------------------------------------GNTLVGAFDL MSMEG_4512|M.smegmatis_MC2_155 ----------------------------------------GDPLVFSADA Mvan_3846|M.vanbaalenii_PYR-1 ----------------------------------------RDPLVLAADR Mb2402c|M.bovis_AF2122/97 ---------------------------------------TVDPLVFAADA Rv2381c|M.tuberculosis_H37Rv ---------------------------------------TVDPLVFAADA TH_3022|M.thermoresistible__bu DGPGQSVTLSPSTLQTLVDCPLRWLLERHGGTDGRDVRSTVGSLVHALAA Mflv_2695|M.gilvum_PYR-GCK ----------------------------------------GDPIVYSADR MAV_2012|M.avium_104 ----------------------------------------SDPLIFDADF MLBr_02356|M.leprae_Br4923 -------------------------------------DAPVHSVVAAADW .:: MMAR_3695|M.marinum_M DRAR--------------------------------PVLETFGYGPLVS- MUL_3638|M.ulcerans_Agy99 DRAR--------------------------------PVLETFGYGPLVS- MAB_2119c|M.abscessus_ATCC_199 TQAR--------------------------------AMLGVFGYGPLLS- MSMEG_4512|M.smegmatis_MC2_155 QR------------------------------------LALFLGTDA--- Mvan_3846|M.vanbaalenii_PYR-1 DR------------------------------------MRMFFGEKP--- Mb2402c|M.bovis_AF2122/97 AR------------------------------------LQMLLDSRQ--- Rv2381c|M.tuberculosis_H37Rv AR------------------------------------LQMLLDSRQ--- TH_3022|M.thermoresistible__bu GRYRTEGQLLAELERVWDQLPFESRWYADNELSRHRAMLQTFMRWRERTR Mflv_2695|M.gilvum_PYR-GCK AR------------------------------------LQIFRDDPAP-- MAV_2012|M.avium_104 ER------------------------------------LQVFFESQG--- MLBr_02356|M.leprae_Br4923 PLLAAAYQTRG--------------------------VLRMVDDLLPAPG : . MMAR_3695|M.marinum_M ------------------------------ELLS---PVS----ETAAPA MUL_3638|M.ulcerans_Agy99 ------------------------------ELLS---PVS----ETAAPA MAB_2119c|M.abscessus_ATCC_199 ------------------------------ELEDNGGPVAPAETTRPAPV MSMEG_4512|M.smegmatis_MC2_155 -------------------------------DTGTGREATHAAQHRDAGP Mvan_3846|M.vanbaalenii_PYR-1 -------------------------------VEKPGEADTGAGPASMAPP Mb2402c|M.bovis_AF2122/97 -------------------------------FERYEGPTDPNLTIVDAVR Rv2381c|M.tuberculosis_H37Rv -------------------------------FERYEGPTDPNLTIVDAVR TH_3022|M.thermoresistible__bu RELTEVAAEIAVDGVLVDGADTTPEIRVRGRLDRLERDADGRLVVVDLKT Mflv_2695|M.gilvum_PYR-GCK --------------------------------PTATSPASGGDTTAVVLA MAV_2012|M.avium_104 -------------------------------MPMPFSDTPTRDDEAAAAP MLBr_02356|M.leprae_Br4923 ------------------------------EVLMQESEFRKALRTCQAER MMAR_3695|M.marinum_M EP--------ADLPGRLSNLLAAAIGAERAERIDTSVPMVALGLDSLQAL MUL_3638|M.ulcerans_Agy99 EP--------ADLPGRLSNLLAAAIGAERAERIDTSVPMVALGLDSLQAL MAB_2119c|M.abscessus_ATCC_199 VS--------ENRSGHLVQLLAEVIGADHADSIDTAMPMVAMGLDSLQAL MSMEG_4512|M.smegmatis_MC2_155 P----ADAEHHDTGAAVRIALAAVLKLADTTGLDLDASLLDLGVDSLLAL Mvan_3846|M.vanbaalenii_PYR-1 --------------DAVRTQLAAVLD-VDAAALDLDSPLFDLGVDSLLAL Mb2402c|M.bovis_AF2122/97 ------------------TQLAAVLGIPQAGEVNLQESLFDLGVDSMLAL Rv2381c|M.tuberculosis_H37Rv ------------------TQLAAVLGIPQAGEVNLQESLFDLGVDSMLAL TH_3022|M.thermoresistible__bu GKSPVTKNDAQRHAQLAMYQLAVAAGLLPAGDIPGGGRLVYLGRPTGGGA Mflv_2695|M.gilvum_PYR-GCK -------------------ELTSVLGIEPAG-VDLDASLLDMGVDSLLAL MAV_2012|M.avium_104 AG--------KPLAEVVRAELAATLHLGDSVSIDPSASLIDLGVDSLLAL MLBr_02356|M.leprae_Br4923 RHN--------MLFDHVSALVAKAMGLLPAETLDPSAGFFQLGMDSLMSV :: . : : :. :* : . MMAR_3695|M.marinum_M ELRRR----VKAEFDHELEVSDLLGGASIADVLAQLGSR----------- MUL_3638|M.ulcerans_Agy99 ELRRR----VKAEFDHELEVSDLLGGASIADVLAQLGSR----------- MAB_2119c|M.abscessus_ATCC_199 EFRRR----VQAELDFELPVQDLLGGASVDHVIDALTAQSR--------- MSMEG_4512|M.smegmatis_MC2_155 DLRKK----LKKTTGRSVPLATLLGGVTATELIEHLER------------ Mvan_3846|M.vanbaalenii_PYR-1 DLRKR----LKRLTGHTVPLATLLGGITGADLIAGLS------------- Mb2402c|M.bovis_AF2122/97 DLRNR----LKRSIGATVSLATLMGDITGDGLVAKLEDADER-----SHT Rv2381c|M.tuberculosis_H37Rv DLRNR----LKRSIGATVSLATLMGDITGDGLVAKLEDADER-----SHT TH_3022|M.thermoresistible__bu TEREQDPLTPETAAGWRDTVAQAADATRGPRFAARINDGCAHCPVRFSCP Mflv_2695|M.gilvum_PYR-GCK DLRKR----LRRATGRSVPLAAMLGGMTGAELITGLDD-----------E MAV_2012|M.avium_104 DLRKR----LRRTVGNSVPVARMLGGITVAELVDALRADATGGPVVPPTI MLBr_02356|M.leprae_Br4923 TLQRA----LSDSLGEFLPASVVFDYPTVYSLTDYLATILPEFLEPEAPS :. . . . : MMAR_3695|M.marinum_M ---------------------------- MUL_3638|M.ulcerans_Agy99 ---------------------------- MAB_2119c|M.abscessus_ATCC_199 ---------------------------- MSMEG_4512|M.smegmatis_MC2_155 PEKETFSRD------------------- Mvan_3846|M.vanbaalenii_PYR-1 -EKVNTSSD------------------- Mb2402c|M.bovis_AF2122/97 AQKVDISRD------------------- Rv2381c|M.tuberculosis_H37Rv AQKVDISRD------------------- TH_3022|M.thermoresistible__bu AQAAQAGSERP----------------- Mflv_2695|M.gilvum_PYR-GCK PQRNEIPA-------------------- MAV_2012|M.avium_104 QRTGAVSGAHPSKLAMLERLDS------ MLBr_02356|M.leprae_Br4923 GRTTADAYDEFTESELLDQLSERLRGTQ