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EQHTLLQREESPRSPAAPSLRRLGGSRHITHWDPEDLGAWEAGNKGIARRNLLWSVVTVHLGYSVWTLWP VLELLMPQDVYGFSTSDKFLLGTIATLFGAFLRMPYALASAIFGGRNWATFSAIVLLIPAIGTTVLLTHP GLPLWPYLVCAALTGLGGGNFASSMSNANAFYPHRLKGSALGIAGGVGNLGVPAIQLVGLLAIATVGERK PYLVCALYVVLVAIAVIGVSLFMNNVEQHRVQVNRLRPIVSAVLSTRDTWLLSLLYLGTFGSFIGFSFVF GQVLQTNFLACGQSPARATLHAVELAFVGPLLAAVARIYGGRLADRVGGSRLTLIVFVAMTLAAGLLISA STLEGRHVGQHRGATMVGYFVCFVALFVLSGLGNGSVYKMIPTIFEACSRSLDLSEAERRDWSRIISGVV IGFVAAFGALGGVGINMALRESYLSTGSGTDAFWIFMMCYAAAAVLTWKVYDRRTVTDMGMLQAALVRQP ASTPAELIGPRTQSDRFSGCSISA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2329c | narK1 | - | 100% (515) | PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK1 (NITRITE FACILITATOR 1) |
| M. tuberculosis H37Rv | Rv0261c | narK3 | e-172 | 62.63% (463) | integral membrane nitrite extrusion protein NarK3 |
| M. tuberculosis H37Rv | Rv0267 | narU | 6e-73 | 37.04% (467) | integral membrane nitrite extrusion protein NarU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2356c | narK1 | 0.0 | 100.00% (515) | nitrite extrusion protein 1 NarK1 |
| M. gilvum PYR-GCK | Mflv_3015 | - | 1e-134 | 52.53% (455) | nitrite extrusion protein |
| M. leprae Br4923 | MLBr_00844 | narK | 0.0 | 69.06% (488) | putative nitrite extrusion protein |
| M. abscessus ATCC 19977 | MAB_3523c | - | 1e-135 | 51.06% (470) | integral membrane nitrite extrusion protein NarK3 |
| M. marinum M | MMAR_3637 | narK1 | 0.0 | 74.31% (506) | integral membrane nitrite extrusion protein NarK1 |
| M. avium 104 | MAV_4899 | - | 1e-159 | 58.61% (459) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0433 | - | 1e-170 | 62.72% (448) | nitrite extrusion protein |
| M. thermoresistible (build 8) | TH_0644 | narK2 | 3e-07 | 25.51% (196) | POSSIBLE NITRATE/NITRITE TRANSPORTER NARK2 |
| M. ulcerans Agy99 | MUL_3265 | narK3 | 1e-158 | 58.59% (454) | integral membrane nitrite extrusion protein NarK3 |
| M. vanbaalenii PYR-1 | Mvan_3492 | - | 2e-71 | 35.61% (469) | nitrite transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3015|M.gilvum_PYR-GCK ------------------------------MTWAFTGVMAKRTRDIDTWD
MAB_3523c|M.abscessus_ATCC_199 -----------------------------MANNTATAPIARRGRWIENWD
Rv2329c|M.tuberculosis_H37Rv MEQHTLLQREESPRSP----------------AAPSLRRLGGSRHITHWD
Mb2356c|M.bovis_AF2122/97 MEQHTLLQREESPRSP----------------AAPSLRRLGGSRHITHWD
MMAR_3637|M.marinum_M MEQQMLLQREESQGSPGR--------------SNAVTRRWGGSRHISHWD
MLBr_00844|M.leprae_Br4923 MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACRISHWD
MAV_4899|M.avium_104 ---------------------------------------MGRDHRITDWN
MUL_3265|M.ulcerans_Agy99 ---------------------------------------MGRSRHIAHWD
MSMEG_0433|M.smegmatis_MC2_155 ------------------------------------MPTLLKPKRITNWD
Mvan_3492|M.vanbaalenii_PYR-1 ----MTVTDSESTGALAT--------------AAPAPERHRGKHWIDDWR
TH_0644|M.thermoresistible__bu --------------------------------------------------
Mflv_3015|M.gilvum_PYR-GCK PEDVQAWEGTGGKAPGKEIAKRNLIWSIVAEHVGFSVWSIWSVMVLFMPQ
MAB_3523c|M.abscessus_ATCC_199 PEDVVAWD-NG----GAKIARRNLIWSVVAEHVGFSVWSIWSVMVLFMPQ
Rv2329c|M.tuberculosis_H37Rv PEDLGAWEAGN-----KGIARRNLLWSVVTVHLGYSVWTLWPVLELLMPQ
Mb2356c|M.bovis_AF2122/97 PEDLGAWEAGN-----KGIARRNLLWSVVTVHLGYSVWTLWPVLELLMPQ
MMAR_3637|M.marinum_M AEDLVAWEAGN-----KRIARRNLLWSVVTVHLGYSVWTLWPVLVLFMPE
MLBr_00844|M.leprae_Br4923 PEDQAAWEAGN-----KTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPK
MAV_4899|M.avium_104 PEDAAAWEAGN-----KRIARRNLLCTIAGDHVAFSIWTLWPVMALFMPA
MUL_3265|M.ulcerans_Agy99 PEDVQAWEAGN-----KAIARRNLVFSIATMHVGFSIWTLWSVMVLFMPQ
MSMEG_0433|M.smegmatis_MC2_155 PEDVAAWEAGN-----KYVARRNLIWSVVAEHIGFSIWSIWSVMVLFMPE
Mvan_3492|M.vanbaalenii_PYR-1 PEDPEFWATTG-----KPVARRNLIFSIFAEHIGFSVWLLWSIVVVQMTA
TH_0644|M.thermoresistible__bu --------------------MIGPLSTTYAVDISLS--------------
. : : .:. *
Mflv_3015|M.gilvum_PYR-GCK DVYG--------IDAAGKFYLVAVPTLVGAFMRIPYTIAPARFGGRNWTI
MAB_3523c|M.abscessus_ATCC_199 NVYH--------IDAAGKFFLVAMPTLVGAVLRLPYTFATAWFGGRNWTV
Rv2329c|M.tuberculosis_H37Rv DVYG--------FSTSDKFLLGTIATLFGAFLRMPYALASAIFGGRNWAT
Mb2356c|M.bovis_AF2122/97 DVYG--------FSTSDKFLLGTIATLFGAFLRMPYALASAIFGGRNWAT
MMAR_3637|M.marinum_M NVYG--------FSAGDKFLLDMVATLVGAGLRIPYSVATTVFGGRNWAT
MLBr_00844|M.leprae_Br4923 DVYG--------FSAGDKFLLATTATLVGACLRVPYSLATALFGGRNWAI
MAV_4899|M.avium_104 AVYG--------FSAGDKLLLGAVATLVGGCARIPYTLGIAAFGGRKWTT
MUL_3265|M.ulcerans_Agy99 SVYG--------ISAANKLLLGATATLVGGCVRIPYVMATARFGGRNWAT
MSMEG_0433|M.smegmatis_MC2_155 AVYG--------FSAGDKFLLGATATLVGSCLRIPYTLATATFGGRNWTV
Mvan_3492|M.vanbaalenii_PYR-1 GADGSPAASGFALTTTQALWLVAVPSGVGAFLRLPYTFAVPVFGGRNWTV
TH_0644|M.thermoresistible__bu --------------SAEASMLVATPILVGAVGRIVVGSLTDRYGGR--AM
: * . .*. *: :*** :
Mflv_3015|M.gilvum_PYR-GCK VSALLLLIPTVLAYYYMKNPAS-YTTYMVIAAFAGLGGGNFASSMTNINA
MAB_3523c|M.abscessus_ATCC_199 FSALVLAVPTALTLYFMAHPETSYTTFMIVAAVAGFGGGNFASSMTNINA
Rv2329c|M.tuberculosis_H37Rv FSAIVLLIPAIGTTVLLTHPGLPLWPYLVCAALTGLGGGNFASSMSNANA
Mb2356c|M.bovis_AF2122/97 FSAIVLLIPAIGTTVLLTHPGLPLWPYLVCAALTGLGGGNFASSMSNANA
MMAR_3637|M.marinum_M FSAAVLLLPVVGTMVLLLHPGLPLWPYLVCAALSGLGGGNFAASMSNANA
MLBr_00844|M.leprae_Br4923 FSVMVLLIPTIATMVLLAHPGLPLWPYLACAALTGLGGGNFAASMTNANA
MAV_4899|M.avium_104 FSAVVLLIPTVGTIVLLANPGLPLWLFVLCAALTGLGGGNYAASLANVNA
MUL_3265|M.ulcerans_Agy99 FSSLVLLVPTVGAIVLLANPGLPLWPYLVCAALSGVGGGNYSASLANVEA
MSMEG_0433|M.smegmatis_MC2_155 FSALVLLIPTVMTVVLMANPGLPLWPYLVCAALAGFGGGNFASSMTNINA
Mvan_3492|M.vanbaalenii_PYR-1 ISALLLLIPCLGLAWAVSNPDINFAVLLLIAATAGFGGGNFASSMANISF
TH_0644|M.thermoresistible__bu FIAITLASIVPVLAVGAAGAAGSYPLLLVFGFFLGIAGTIFAVGIPFANN
. * . : . *..* :: .:. .
Mflv_3015|M.gilvum_PYR-GCK FYPQRLKGWALGLNAGGGNIGVPVIQLIGLMVIAAVGNTRPEIVCAIYLV
MAB_3523c|M.abscessus_ATCC_199 FYPQRFKGWALGLNAGGGNIGVPVIQVIGLLVIATVGNRSPHWVAAIYLV
Rv2329c|M.tuberculosis_H37Rv FYPHRLKGSALGIAGGVGNLGVPAIQLVGLLAIATVGERKPYLVCALYVV
Mb2356c|M.bovis_AF2122/97 FYPHRLKGSALGIAGGVGNLGVPAIQLVGLLAIATVGERKPYLVCALYVV
MMAR_3637|M.marinum_M FYPHRLKGSALGIAGGIGNLGVPAIQLMGLLIIAVAGEGKPYLICALYSV
MLBr_00844|M.leprae_Br4923 FYPHRLKGAAFGLAGGAGNLGVSVIQVVGMLVIASVGDRKPYIVCGLYVV
MAV_4899|M.avium_104 FYPQRLKGAAMAVNAGVANLGVAVIQLVGLLVLATAGHQAPYWVCAVYLV
MUL_3265|M.ulcerans_Agy99 FYPQRLKGVALGLTGGIGNLGVTAIQAVGLLVLATAGHEAPYWVCAVYLV
MSMEG_0433|M.smegmatis_MC2_155 FYPQRLKGWALGLNAGGGNIGVPMIQLVGLFVIATAGNRAPYWVCAVYLV
Mvan_3492|M.vanbaalenii_PYR-1 FYPESEKGWALGLNAAGGNIGVAVAQKIIPVVVTLGAGVALSLAGLFYIP
TH_0644|M.thermoresistible__bu WYAPSRRGFATGVFG-MGMVGTALSAFFTPRFVESFG---LFTTHVIIAV
:*. :* * .: . . :*.. . : . .
Mflv_3015|M.gilvum_PYR-GCK AISGAAVGAALFMDNLRNQKSNFGALV----EAMRFKHSWVMSFLYIGTF
MAB_3523c|M.abscessus_ATCC_199 LIAFAAVGAALFMDNLADQKTDGRSLI----DVMKYRDSWIIAFLYIGTF
Rv2329c|M.tuberculosis_H37Rv LVAIAVIGVSLFMNNVEQHRVQVNRLRPIVSAVLSTRDTWLLSLLYLGTF
Mb2356c|M.bovis_AF2122/97 LVAIAVIGVSLFMNNVEQHRVQVNRLRPIVSAVLSTRDTWLLSLLYLGTF
MMAR_3637|M.marinum_M FLAIAAIGVALSMNNVAQHRVKARHMRPIVTTVLANRDTYLLSLLYLGTF
MLBr_00844|M.leprae_Br4923 LLIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLALLYLASF
MAV_4899|M.avium_104 FLAAVAIAAAMFMDDIN-HGTQLSTMR----SILFERDTHVISLLYIATF
MUL_3265|M.ulcerans_Agy99 LIAIAGLGAALFMENLT-HVIEVGHVR----SVLAVPDTWSVSFLYMCAS
MSMEG_0433|M.smegmatis_MC2_155 ALAVAGLGAALYMDNLEHHKIDLGAMK----AILGERDTWIISLLYIGTF
Mvan_3492|M.vanbaalenii_PYR-1 FTVAAAVCAFLFMNNLTEAKADVKPVW----ESLRHADTWIMSLLYIGTF
TH_0644|M.thermoresistible__bu ALGLTALLCLVAMHDSPDFTPNTERVLPKLKAAARLPVTWEMSILYAIVF
. : : *.: : : :::**
Mflv_3015|M.gilvum_PYR-GCK GSFIGFSFAFGQVLQINYLAG--------GDTPAQASLHAAQIAFLGPLL
MAB_3523c|M.abscessus_ATCC_199 GSFIGFSFAFGQVLQLNFLAGLAHSGVTPAQAAAQASLHAAQIAFIGPLL
Rv2329c|M.tuberculosis_H37Rv GSFIGFSFVFGQVLQTNFLAC--------GQSPARATLHAVELAFVGPLL
Mb2356c|M.bovis_AF2122/97 GSFIGFSFVFGQVLQTNFLAC--------GQSPARATLHAVELAFVGPLL
MMAR_3637|M.marinum_M GSFIGFSFAFGQVLQTNFMAI--------GEHAAQATLHAAELAFLGPLL
MLBr_00844|M.leprae_Br4923 GSFIGFSFAFGQVLETNFVAG--------GQSTAQAALHAAELAFIGPTL
MAV_4899|M.avium_104 GSWIGFSFAFGQVMQVNFLEN--------GESAKHAALHAAQLAFIGPLL
MUL_3265|M.ulcerans_Agy99 GSFIGFAFVFGQVLQFNLLAG--------GQSTAQASLHAAEIAFVGPLL
MSMEG_0433|M.smegmatis_MC2_155 GSFIGFAFAFGQVLQINFISG--------GQTPAQASLHAAQIAFIGPLL
Mvan_3492|M.vanbaalenii_PYR-1 GSFIGYSAAFPTLLKAVFDRG----------------DIALMWAFLGAGI
TH_0644|M.thermoresistible__bu GGFVAFSNYLPTYXPSSPACT----------------------------I
*.::.:: : :
Mflv_3015|M.gilvum_PYR-GCK GSISRPFGGKLADRVGGGRITLYVFVAMIF-AAGVLVATGVMDDAAAGAP
MAB_3523c|M.abscessus_ATCC_199 GSLARPFGGWLSDRTGGGKISLYAFIAMIF-GAGILVAAGTISDRGAGAP
Rv2329c|M.tuberculosis_H37Rv AAVARIYGGRLADRVGGSRLTLIVFVAMTL-AAGLLISASTLEGRHVGQ-
Mb2356c|M.bovis_AF2122/97 AAVARIYGGRLADRVGGSRLTLIVFVAMTL-AAGLLISASTLEGRHVGQ-
MMAR_3637|M.marinum_M AAVARIYGGRLADRLGGSRITLVVFVAMTV-VAGLLISASSLEGRHSGP-
MLBr_00844|M.leprae_Br4923 AAVARFWGGRLADRLGGSRVTLVVFGAMVF-AAGLLGVLGIIEGSRVCP-
MAV_4899|M.avium_104 GSVARIYGGRLADRVGGSRVTLGVLAAMTL-AAGLLVIVSTVDDQHAGA-
MUL_3265|M.ulcerans_Agy99 GSLARIVGGKLGDRFGGGRVTLGVFVAMIL-SAALLVAVNTHADLNHGAG
MSMEG_0433|M.smegmatis_MC2_155 GSLSRVYGGKLADRIGGGRVTLAVFAGMIL-GAGLLVAVSTVSDGSSEA-
Mvan_3492|M.vanbaalenii_PYR-1 GSVARPLGGKLSDRVGGARITAVSFAMLAIGAAGALWSVQAKN-------
TH_0644|M.thermoresistible__bu TTCTSTPPPRHSTRFG----------------------------------
: : . * *
Mflv_3015|M.gilvum_PYR-GCK ---TSAQMIGYVAGFILLFILSGLGNGSTYKMIPSIFEAKAQGRDDLDKE
MAB_3523c|M.abscessus_ATCC_199 ---SGSIMTAYVIGFIILFVVSGIGNGSVYKMIPSVFAAKARSAG-LDET
Rv2329c|M.tuberculosis_H37Rv --HRGATMVGYFVCFVALFVLSGLGNGSVYKMIPTIFEACSRSLDLSEAE
Mb2356c|M.bovis_AF2122/97 --HRGATMVGYFVCFVALFVLSGLGNGSVYKMIPTIFEACSRSLDLSEAE
MMAR_3637|M.marinum_M --MRGATMTGYFVCFIALFVLAGLGNGSVYKMIPTIFAACGRSLDHGPSA
MLBr_00844|M.leprae_Br4923 --IRGVMMASYFAGFITLFILSGLGNGSVYKMIPTIFEACSHSLGINDDE
MAV_4899|M.avium_104 ---HSVSMIGYVVGFMVLFILSGMGNGSVFKLIPSVYEARSRGRDTSEDE
MUL_3265|M.ulcerans_Agy99 GRMTAATLIGYVSGFIALFIFCGMGKGTVFELIPSIFAERSQHLDISDMQ
MSMEG_0433|M.smegmatis_MC2_155 --ATGLMMSGYVVGFIALFLLSGIGNGSVYKMIPSIFEARSHSLDVSEDE
Mvan_3492|M.vanbaalenii_PYR-1 -------MPVFFIAFMFLFVATGIGNGSTYRMISKIFRVKGEDAGGDPLT
TH_0644|M.thermoresistible__bu ---------------------SGPGRSGPAGSWPMCSPPRNPVTTAGSGR
* *.. .
Mflv_3015|M.gilvum_PYR-GCK G---KAAWSRAMSGALIGFAGAVGALGGVFINVVLRASYVGDAKSATAAF
MAB_3523c|M.abscessus_ATCC_199 -------WSRTMSGALIGVAGAIGALGGVAINLVLRASYLSAAKSATMAF
Rv2329c|M.tuberculosis_H37Rv ----RRDWSRIISGVVIGFVAAFGALGGVGINMALRESYLSTG-SGTDAF
Mb2356c|M.bovis_AF2122/97 ----RRDWSRIISGVVIGFVAAFGALGGVGINMALRESYLSTG-SGTDAF
MMAR_3637|M.marinum_M GGLDHRDRPRVISGVVIGFVSALGALGGVGINLALRESFVATG-TTTDAF
MLBr_00844|M.leprae_Br4923 ----CRDWSRVISGVVIGFVAEVGALGGVGIDLALRESYLNTG-GVTAAF
MAV_4899|M.avium_104 ----RRQWARAMAGSLIGICSAVGAFGGVAINLALRQSYLSTG-TETSAY
MUL_3265|M.ulcerans_Agy99 ----RRQWARIVSGALIGFAGSVGALGGVGINLALRQSYVHSG-TETPAF
MSMEG_0433|M.smegmatis_MC2_155 ----RRHWSRSMSGALIGFAGAVGALGGVGINMALRQSYLSSG-SATTAF
Mvan_3492|M.vanbaalenii_PYR-1 -----MLHMRRQAAGALGIISSVGAFGGFIVPLAYAWSKSQFG-NIQPAL
TH_0644|M.thermoresistible__bu -----SAITRRSRGHWIGVRSTR------------SHPMCRCGCSTAAAC
* . :*. . . . *
Mflv_3015|M.gilvum_PYR-GCK WVFLAFYVVCAFVTWFVFLRLQ------EHRAHSGEHIGRTSAPVPVG--
MAB_3523c|M.abscessus_ATCC_199 WVFLVFYVICAAVTWYAYVRRP------MTVSVP--AISSSKNEVAV---
Rv2329c|M.tuberculosis_H37Rv WIFMMCYAAAAVLTWKVYDRRTVTDMGMLQAALVRQPASTPAELIGPRTQ
Mb2356c|M.bovis_AF2122/97 WIFMMCYAAAAVLTWKVYDRRTVTDMGMLQAALVRQPASTPAELIGPRTQ
MMAR_3637|M.marinum_M WLFMVFYAGAAALTWKVYVRRPVVGIQALPPAIAPQPAPAAAELLGS---
MLBr_00844|M.leprae_Br4923 WIFMLCYAAAGVLTWKMYVCRP------LPGNLHDEAANAFAASVGASRT
MAV_4899|M.avium_104 WTFMASYVVAAIMTWLVYVR--------RPVT-APGVSLPETQAARL---
MUL_3265|M.ulcerans_Agy99 WAFLVCYLCAAALTWARYVRPR------SPVASAPRKPNEDPQLSGAAA-
MSMEG_0433|M.smegmatis_MC2_155 WTFLAFYVLASVVTWFCYVRRP-------AAMPVTGTERHAPAIAG----
Mvan_3492|M.vanbaalenii_PYR-1 QFYVGFFIVLLGVTWFFYMRKG-----------------TRMAQAGV---
TH_0644|M.thermoresistible__bu CGR-----------------------------------------------
Mflv_3015|M.gilvum_PYR-GCK -----------
MAB_3523c|M.abscessus_ATCC_199 -----------
Rv2329c|M.tuberculosis_H37Rv SDRFSGCSISA
Mb2356c|M.bovis_AF2122/97 SDRFSGCSISA
MMAR_3637|M.marinum_M -----------
MLBr_00844|M.leprae_Br4923 HRG--------
MAV_4899|M.avium_104 -----------
MUL_3265|M.ulcerans_Agy99 -----------
MSMEG_0433|M.smegmatis_MC2_155 -----------
Mvan_3492|M.vanbaalenii_PYR-1 -----------
TH_0644|M.thermoresistible__bu -----------