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VRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDYLTRRPQRTGEDHCPLTHDDY RRFLAGKPDGVADFLAARGIRLPPGSPTDLTDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVA GVRVAAHTSHRNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANPGRCVVIDSCQ TGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGR RPAVFLDFDGTLSDIVERPEAATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFE LVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVHYRNVADDSVDNLIAAVRRLG HAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGI VVRHNEHGDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDPWTLVFHGYDPGQERLREALCAVGNGY LGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGCTVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELL SYRQTFDLRRATLTRSLRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDGGVHN TLVDRYRQLSSQHLTTAEIEVLADSVLLRTQTSQSGIAIAVAARSTLWRDGQRVDAQYRVARDTNRGGHD IQVTLSAGQSVTLEKVATIFTSRDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNT EELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLSLRMPKVARSLLDYRYR RLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQLHLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTG DRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNVMAVWVI LRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFHDGVISQFEGYSELAELDWDHYRHRYG NIQRLDRILEAEGDSVNNYQASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGS TLSAVVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLV LSPQWPEALGPLEFPFVYRRHQLSLRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2006 | otsB1 | - | 100% (1327) | PROBABLE TREHALOSE-6-PHOSPHATE PHOSPHATASE OTSB1 (TREHALOSE-PHOSPHATASE) (TPP) |
| M. tuberculosis H37Rv | Rv3372 | otsB2 | 1e-98 | 56.64% (339) | trehalose 6-phosphate phosphatase |
| M. tuberculosis H37Rv | Rv3401 | - | 1e-49 | 26.98% (782) | hypothetical protein Rv3401 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2029 | otsB1 | 0.0 | 99.85% (1327) | trehalose-6-phosphate phosphatase OtsB1 |
| M. gilvum PYR-GCK | Mflv_4989 | - | 0.0 | 60.70% (1140) | HAD family hydrolase |
| M. leprae Br4923 | MLBr_00414 | otsB2 | 1e-106 | 52.70% (408) | putative trehalose-6-phosphate phosphatase |
| M. abscessus ATCC 19977 | MAB_0578c | - | 2e-20 | 32.13% (249) | putative trehalose phosphatase |
| M. marinum M | MMAR_2257 | otsB1 | 0.0 | 59.09% (1193) | trehalose-6-phosphate phosphatase OtsB1 |
| M. avium 104 | MAV_4338 | - | 2e-97 | 53.89% (373) | glycosyl hydrolase |
| M. smegmatis MC2 155 | MSMEG_3954 | - | 0.0 | 62.95% (861) | trehalose 6-phosphate phosphorylase |
| M. thermoresistible (build 8) | TH_1155 | - | 0.0 | 58.79% (961) | trehalose 6-phosphate phosphorylase |
| M. ulcerans Agy99 | MUL_0921 | otsB2 | 1e-101 | 58.16% (337) | trehalose-6-phosphate phosphatase OtsB2 |
| M. vanbaalenii PYR-1 | Mvan_4107 | - | 0.0 | 59.40% (1192) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY
Mb2029|M.bovis_AF2122/97 MRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDY
MMAR_2257|M.marinum_M ----------MKSFTIDPRRHDGVIFVLDGDGHEQS-IWEPTV-------
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 ---------MKLPVTIDPRYHDAVLLDLDGALTSEAPLFGPTV-------
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK -----------MPVFIDPRHHDAVIFEVDDPVADEVALSASQG-------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv LTRRPQRTGEDHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDL
Mb2029|M.bovis_AF2122/97 LTRRPQRTGEDHCPLTHDDYRRFLAGKPDSVADFLAARGIRLPPGSPTDL
MMAR_2257|M.marinum_M --------------------------------------------------
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH
Mb2029|M.bovis_AF2122/97 TDDTVYGLQNLERQTFLQLLNTGVPEGKSIASFARRLQVAGVRVAAHTSH
MMAR_2257|M.marinum_M -------------------------------ALARKLWQVGVGTAVYSPT
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 -------------------------------DLARKLQSIGVAAAAYSSN
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK -------------------------------DLARRLTAAGIGVGCAES-
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP
Mb2029|M.bovis_AF2122/97 RNYGHTLDATGLAEVFAVFVDGAVTAELGLPAEPNPAGLIETAKRLGANP
MMAR_2257|M.marinum_M DESVRVLDAAGLSEPEQVSAP-----PQASRAKPYCVGLSAAAAKLGAAV
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 GQCRQALKAAGIDDLFGVCID-GMEGDRGTAEKPDPAVLLEAARRIGARP
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK ------------------------------------AMLRETARRLGVHP
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA
Mb2029|M.bovis_AF2122/97 GRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSGADAVVADLAA
MMAR_2257|M.marinum_M QRLAVVAGMDGGVEAARECGFAFVIGFDRDGRAEELLRRGADVVAADLAE
TH_1155|M.thermoresistible__bu --------------------------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 QRCVVVENSAAGVAAGRAGGFALVVGIDGTEVADELTRHGADVVLAGLAD
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK GRCVVVAGGEAGVRTARAGGFALIVGIDRAERAEDLRSCGADVVVPDLVA
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE
Mb2029|M.bovis_AF2122/97 VTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE
MMAR_2257|M.marinum_M VTVRTGDERLSQCPNALDSYGQVIGMVAGRQLFVCMDYDGTLSEIVSEPD
TH_1155|M.thermoresistible__bu ------------LSNALASYGLLIGIVANRQPVVFCRFDGAL----ADRD
Mvan_4107|M.vanbaalenii_PYR-1 IAVRTGDRRISELPNALASYGQLIGITSARESMLFLDYDGTLSPIVSDPA
MSMEG_3954|M.smegmatis_MC2_155 ---------------------------------MEHHTDAAQDDVVTDDE
Mflv_4989|M.gilvum_PYR-GCK VTVRDGYRRMSELADALQSYGEIVPLAETRTPVVLLDFDGTLSDIVGDPD
MAB_0578c|M.abscessus_ATCC_199 --------MVSAQDLPVELRRALSEVARTPRLLVASDYDGTIAPLVNNPD
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv AATLVDGAAEALRALA--AQCPVAVISGRDLADVRNRVKVDGLWLAGSHG
Mb2029|M.bovis_AF2122/97 AATLVDGAAEALRALA--AQCPVAVISGRDLADVRNRVKVDGLWLAGSHG
MMAR_2257|M.marinum_M AATLVDGAAEALAHLS--TQCPVAILSGRDLTDIRDRVGVPGIWYAGSHG
TH_1155|M.thermoresistible__bu TATLVDGAAAALRKLA--SLCPVAVISGREVSELRARVGVDGLWYAGGHG
Mvan_4107|M.vanbaalenii_PYR-1 AARLVEGADEALELVS--KVCPVAILSGRDLADVSARVGTPGVWYAGSHG
MSMEG_3954|M.smegmatis_MC2_155 DRRPIADLPDALDHFD--EIR--------DLLAFRN--------------
Mflv_4989|M.gilvum_PYR-GCK TAALVPGARSVLDALA--ARCPVAVVSGRALADIRDRIGVPGIWYAGSHG
MAB_0578c|M.abscessus_ATCC_199 HARPHPESTTALRALAGLPSTTSALISGRALRDLATLSRLPSEVHLVGSH
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv FELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVA
Mb2029|M.bovis_AF2122/97 FELVAPDGSHHQNAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVA
MMAR_2257|M.marinum_M FELIAPDGTHHQHEAAAAAVDVLASAAKDLRHELAQIPGVSVEHKRFGVA
TH_1155|M.thermoresistible__bu REVVAPDGSHHRFDG-----------------------------------
Mvan_4107|M.vanbaalenii_PYR-1 FELTSPDGAYHCNDAAAVFVPVLEEAAAELNKTLAQIAGVRVEHKRFAVA
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK FELCSPDGGIQENEAGLEIVRVLAGALAEVRERVGAVDGVLIEDKRFSIA
MAB_0578c|M.abscessus_ATCC_199 GSEFDAGFVHAIDG------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv VHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKAL
Mb2029|M.bovis_AF2122/97 VHYRNVADDSVDNLIAAVRRLGHAAGLRVTTGRKVVELRPDIAWDKGKAL
MMAR_2257|M.marinum_M VHYRNVAREHVAQVIATTHRYRREYGLRVTSGRKVVELRPDIDWDKGAAL
TH_1155|M.thermoresistible__bu -----------------------------------------TDWDPGAAL
Mvan_4107|M.vanbaalenii_PYR-1 VHYREVAPEQVSEIVSATHQLGARRGLRVTSGRMLVELRPDLDWDKGTTL
MSMEG_3954|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4989|M.gilvum_PYR-GCK VHYRNVAAESVDEVVTAVRNIAQCNGLRADGGRRVVELKPDTGWHKGRAV
MAB_0578c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv DWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEH
Mb2029|M.bovis_AF2122/97 DWIGERLGPAEVGPDLRLPIYIGDDLTDEDAFDAVRFTGVGIVVR-HNEH
MMAR_2257|M.marinum_M AWIRSLIF----EDSRVLPMYVGDDLTDEDAFDALRFSGVGIVVR-HDED
TH_1155|M.thermoresistible__bu TSIRARMG----RPEPVLPIYVGSELADEAAFDVLRLDGVSVVVH-HLGA
Mvan_4107|M.vanbaalenii_PYR-1 AWIRDRID----PSGSLLPIYIGDDLTDEDAFDAVRFDGIGIVVG-HDED
MSMEG_3954|M.smegmatis_MC2_155 --------------PASLPVFIG-NPADDSAFRTVRRDGIGIVVVTHAED
Mflv_4989|M.gilvum_PYR-GCK EWILDRID----GDELLLPVYIGDDLTDEDGFDAVRLRGIGVAVR-SAES
MAB_0578c|M.abscessus_ATCC_199 -----------------DAKALLKTIATKLSAIAAEYPGVAIELKPASVA
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv GDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQ
Mb2029|M.bovis_AF2122/97 GDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDP-WTLVFHGYDPGQ
MMAR_2257|M.marinum_M GDRPTAANFTLRNPNEVRDFVRRGAGWLAHAHETQSRGWTFTFEGYDPPN
TH_1155|M.thermoresistible__bu ADRPTGAQFRLDGAEEVCEFLRRGGNWIAYQRQTSNEAWTFSYRGYDPRQ
Mvan_4107|M.vanbaalenii_PYR-1 GDRKTAANFTLQSPEQVREFIQRGSRWLAYKHQVSGEAWDYVFDGYDPQN
MSMEG_3954|M.smegmatis_MC2_155 EKRSTTATFRLDSPGAAATFRHR-LAQEADRPTSIDPGWVLTFDGYDPAN
Mflv_4989|M.gilvum_PYR-GCK GDRRSAARFALDSPAAVCAFLARLSDQLAVEQDLTNDPWTLTFGGYLPED
MAB_0578c|M.abscessus_ATCC_199 LHVRNAS-----EEDADAALRQALSVANGWGAQVTEGKKVLEFAVIPTDK
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv ERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGC
Mb2029|M.bovis_AF2122/97 ERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGC
MMAR_2257|M.marinum_M EKLREALCTVGNGYFATRGAAPESKAGQVHYPGTYAGGVFNRLDDLIGGT
TH_1155|M.thermoresistible__bu EKLREALCTVGNGYFATRGAAPEARAGQVHYPGTYAAGVFNRLDDVVDGR
Mvan_4107|M.vanbaalenii_PYR-1 EKLREALCTVGNGYFATRGAAPESKAGQVHYPGTYAAGVYNRLVDNVSGT
MSMEG_3954|M.smegmatis_MC2_155 ERFREALCTLGNGYFATRGCAPEAPAGRFHYPGTYVAGIYNRLTDEIAGH
Mflv_4989|M.gilvum_PYR-GCK ERLREALCTLGNGYLATRGAAPECDASRLHYPATYVAGIYNRLFDEIAGT
MAB_0578c|M.abscessus_ATCC_199 GQALDILRHQEGATAAVFFGDDVTDEKAFKRLHGPDVGVKVGDGETLAGY
MLBr_00414|M.leprae_Br4923 -----------------------------------MPVTIDPRRHSAA--
MUL_0921|M.ulcerans_Agy99 -----------------------------------MSVTIDPRRH-----
MAV_4338|M.avium_104 -------------------------------MGESGPVVIDPRRH-----
Rv2006|M.tuberculosis_H37Rv TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS
Mb2029|M.bovis_AF2122/97 TVDNESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRS
MMAR_2257|M.marinum_M RTAHESLVNLPNWLPLTFRIDGGDWFDVDAVTLLSYRQTLDLRGAVLTRE
TH_1155|M.thermoresistible__bu VTAHESMVNLPNWLPLTFRIEGGPWFDVDAVTLLDYRQTLDLRGAVLTRE
Mvan_4107|M.vanbaalenii_PYR-1 EIDNESLVNLPNWLALTFRVDHGDWFDIDAVTVLSYRQTLDLRGAVLTRQ
MSMEG_3954|M.smegmatis_MC2_155 RTDNESLVNLPNWLALTFRFDDGPWLDVDDTDLQSYQQTLDLRRGVLTRQ
Mflv_4989|M.gilvum_PYR-GCK TVDNESLVNLPNWLPVTFRVDGGAWFDIDAVEFTSYVTTLDLRRATLTRE
MAB_0578c|M.abscessus_ATCC_199 RIPDTESVGT----ALAFLLEERRTWLLGGHATPIERLTMLANSRTIALV
.: .
MLBr_00414|M.leprae_Br4923 -LFDLDAVVTDTPLDSTVTLVRQLQGIGVGTAVFSTNRNSQGVLTATGLD
MUL_0921|M.ulcerans_Agy99 -----DAVLFDTALNSTQALVRQLQQARVGTATFASG-------------
MAV_4338|M.avium_104 -----DAVLFGVGDALGSALASQLGQIGVGTAAIAAD-------------
Rv2006|M.tuberculosis_H37Rv LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG
Mb2029|M.bovis_AF2122/97 LRFRDAGGRVTTMTQERFASMNRPNLVALQTRIESENWSGTVDFRSLVDG
MMAR_2257|M.marinum_M LTFRDDAGRTSSVTQHRFVSMNQAHVAALQTTIVGHDWSGTIEIRSTIDG
TH_1155|M.thermoresistible__bu LRFRDNAGRTTSVTQQRFVAMHTAHIAALETTLVAEDWSGTVDVRSTLDG
Mvan_4107|M.vanbaalenii_PYR-1 VRFRDHAGRTSSLTQRRFVAMHLPHAGALETTVVAEDWSGTIEFRSTVDG
MSMEG_3954|M.smegmatis_MC2_155 FRFCDKAGRVATVTQHRLVAMHLPHLAMLQTMVTAENFSGTVEFRSEIDG
Mflv_4989|M.gilvum_PYR-GCK FVMRDQAGRITRIRQRRLVAMHRPHVAAMATTVRAENWSGRLQLRSVLDG
MAB_0578c|M.abscessus_ATCC_199 TPTGDVTWMCHPEPDSAAVFAHLLGGPEAGHFTIGPARSALP----LGQK
. .
MLBr_00414|M.leprae_Br4923 HLFPVHVDGLASGKVTILVAAANRLMAQPGRCVVVAVDAAGITAARYG--
MUL_0921|M.ulcerans_Agy99 -------GGGHDAAIQALIESADRVGARPGRCVVITADAASVAAARDS--
MAV_4338|M.avium_104 ----------------DPAAAADRLRVRPGRCVVVAGDPAAVEAARAA--
Rv2006|M.tuberculosis_H37Rv GVHNTLVDRYRQLSSQHLTTAEIEVLA-DSVLLRTQTSQSGIAIAVAARS
Mb2029|M.bovis_AF2122/97 GVHNTLVDRYRQLSSQHLTTAEIEVLA-DSVLLRTQTSQSGIAIAVAARS
MMAR_2257|M.marinum_M NVRNSGVERYRNLASNHLQGLQKAVLSENSVSMAVETTQSKIPVAVAART
TH_1155|M.thermoresistible__bu DVRNGLVERYRDLRGDHLESLGKSALTGDSVLLSVRTNQSRIPIAMAART
Mvan_4107|M.vanbaalenii_PYR-1 NVTNSLVERYRDLANEHLDSADTQELSNNSVLLTMQTNQSRIPIAMAARN
MSMEG_3954|M.smegmatis_MC2_155 AVTNSLVERYRDLSNVHLVGHEKRSLTADSLLLTAHTCQSHIRVAVALRN
Mflv_4989|M.gilvum_PYR-GCK GVENLGVERYRALSSRHLTVDAMRELSRDAVLLQTHTGESQIQIAVAARH
MAB_0578c|M.abscessus_ATCC_199 YIDSTMTVETRWASLQVTDYLAHDEVPGRTDLIRVVTGEADAVVTFAPR-
: : :
MLBr_00414|M.leprae_Br4923 ----------------------GFALVLGLVIGEDQTGHRDTLRNSGADT
MUL_0921|M.ulcerans_Agy99 ----------------------GFALVIG----VDQAGHRDALPDHGADT
MAV_4338|M.avium_104 ----------------------GFALVIG---LAPDGRDGDGLRAAGADA
Rv2006|M.tuberculosis_H37Rv TLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDA
Mb2029|M.bovis_AF2122/97 TLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQSVTLEKVATIFTSRDA
MMAR_2257|M.marinum_M SLWRADEPVAATYRLLDEEFEIGHEIFTEAKLGQPLTVEKIVTLVSGLDV
TH_1155|M.thermoresistible__bu TAWRDGDPVSAGYRLVDEESEIGHQITTGLSRGQRLTVEKVVALSTGRDV
Mvan_4107|M.vanbaalenii_PYR-1 TVWRDGEPVPAAFALFDQGAEIGHDIAVHLSAGDAVTLEKVVTVYTGRDV
MSMEG_3954|M.smegmatis_MC2_155 TVWRGDSPARADYTLVDDRRRAGHVISCYIEAGQPVTLEKAVSVATSRDH
Mflv_4989|M.gilvum_PYR-GCK RVT-GGEPESVDQRVFRDDCRIGHDIEVVVTAGQAVTLEKVIAVYTGRDH
MAB_0578c|M.abscessus_ATCC_199 ------------------------PEFGQAPVQLVAEADGLRVLGTNDPI
. .
MLBr_00414|M.leprae_Br4923 VVADLGEVIVRTGDR--RMSELPDALQTL-------------GLTDDLTA
MUL_0921|M.ulcerans_Agy99 VLADLDEVRVRAGDR--HMSELPDALQAL-------------GRPDGLTV
MAV_4338|M.avium_104 VIAELEQITVRTGDR--RMSQLPDASQALT------------GGADGLAG
Rv2006|M.tuberculosis_H37Rv ATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRL
Mb2029|M.bovis_AF2122/97 ATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNTEELRL
MMAR_2257|M.marinum_M ATSHPAIGAERRLGRQGRFAEICDAHRIAWSHLWERLSIEFSNHTEELRV
TH_1155|M.thermoresistible__bu GSSEPSESAERILERQGRFGEIRAAHTVAWAHLWRRLSIEFEDHTDELRV
Mvan_4107|M.vanbaalenii_PYR-1 AISEPGVNAQRWVTRLGRFDELLDGHRTAWTHLWERLSIDFDDFTDELRI
MSMEG_3954|M.smegmatis_MC2_155 ATCEAANEATRRLQWVDRYHDVQQAHTTAWGQLWERFDVDIGGRTDELRT
Mflv_4989|M.gilvum_PYR-GCK GMSGPVTAAEREIAGADTFDRLEDGHRLAWAHLWERFNIDMGHDPNLLRL
MAB_0578c|M.abscessus_ATCC_199 VLRAPGVTWTIGADDQTATATISPANGPIILELRCGTEDLGENPTSEPEL
: ..
MLBr_00414|M.leprae_Br4923 RQPAVFFDFDGTLSDIVDDPDSARPVPGATEALQK-------------LA
MUL_0921|M.ulcerans_Agy99 PRPAVFFDFDGTLSEIVDDPDAATPTAGAVAALQQ-------------LA
MAV_4338|M.avium_104 RHPAVFFDFDGTLSDIVDDPDAARPVAGATAALTR-------------LA
Rv2006|M.tuberculosis_H37Rv VRLHLLHLLQ-TISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLS
Mb2029|M.bovis_AF2122/97 VRLHLLHLLQ-TISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLS
MMAR_2257|M.marinum_M LRLHLLHLLQ-TVSYNSADLDVGVPARGLHGEAYRGHIFWDELFIFPVLN
TH_1155|M.thermoresistible__bu MRLHLLHLLQ-TVSPHSADLDIGPPARGLHGEAYRGHIFWDELFIFPVLN
Mvan_4107|M.vanbaalenii_PYR-1 LRLHLLHLLQ-TVSLNTADLDAGVPARGLHGEAYRGHIFWDELFIFPVLN
MSMEG_3954|M.smegmatis_MC2_155 VRLHLLHTLQ-TLSPHVRDLDIGVPARGLTGEAYRGHIFWDELFVAPVVS
Mflv_4989|M.gilvum_PYR-GCK VRLHQLHLLQ-TLSPHTADLDVGVPARGLHGEAYRGHVFWDELFVFPVLN
MAB_0578c|M.abscessus_ATCC_199 RERAESYWRDWAQTLTLPERKPGLMKR--SALTLRGLVHAESGAILAAAT
. . : : : : . . :
MLBr_00414|M.leprae_Br4923 THCPVAILS-----------GRDLADVIKRIGVPGIWYSGSHGFEST---
MUL_0921|M.ulcerans_Agy99 AQCPVAILS-----------GRDLADVSQRVGLPGIWYAGSHGFELT---
MAV_4338|M.avium_104 ARCPVAVLS-----------GRDLADVTKRVGVPGIWYAGSHGFELT---
Rv2006|M.tuberculosis_H37Rv LRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQL
Mb2029|M.bovis_AF2122/97 LRMPKVARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQL
MMAR_2257|M.marinum_M LRLPAVTRSLLLYRYRRLLEAQRAAKLAGYRGAMYPWQSGSDGREESPEQ
TH_1155|M.thermoresistible__bu LRFPMITRSLLQYRYRRLPEARRAARLAGYRGAIFPWQSGSDGREESPEL
Mvan_4107|M.vanbaalenii_PYR-1 LRAPMITRSLLGYRYRRLPEARHAARAAGHSGAMFPWQSGSDGREESQRL
MSMEG_3954|M.smegmatis_MC2_155 LRRPALTRALLAYRHRRLPEARRAARDAGFTGAMFPWQSGSNGREESPAL
Mflv_4989|M.gilvum_PYR-GCK MRLPKVTRSLLLYRYRRLPEARRAAAEAGYAGAMFPWQSGSDGREESQRL
MAB_0578c|M.abscessus_ATCC_199 TSLPEDIGGIRNWDYR--YCWLRDASMTASALVALGSLSEAEGLLGWLHR
* . * : :.*
MLBr_00414|M.leprae_Br4923 ---------APDGT---HHQNDAAEATIPILEQAATQLRDQLGPIPGVMV
MUL_0921|M.ulcerans_Agy99 ---------APDGT---HHQNEAAAAAIPVLEQAAAQLRDRLGSIPGVMV
MAV_4338|M.avium_104 ---------APDGS---HHQNDDAAAAIPVLAQAAGRLSDELGTIPGVVV
Rv2006|M.tuberculosis_H37Rv HLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLV
Mb2029|M.bovis_AF2122/97 HLNPRSGRWTPDPSDRAHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLV
MMAR_2257|M.marinum_M HLNPRSGRWIPDASHRAHHIGIAVAYNVWQFYQVTGDLAFMIDYGTEMMA
TH_1155|M.thermoresistible__bu HLNPRSGRWNSDPSHRAHHIGIAIAYNVWQFYQVTGDLAYLIDHGAELLV
Mvan_4107|M.vanbaalenii_PYR-1 HLNPRSGRWNPDASARAHHIGIAVAYSAWKFYQVTGDLAYLIDYGAELIA
MSMEG_3954|M.smegmatis_MC2_155 HLNPRSGRWNPDPSALAHHVGLAVAYNIWQYYQVTDDLEYLIDYGAETLL
Mflv_4989|M.gilvum_PYR-GCK HLNPRSGRWNPDASARAHHVGLAIAFNIWQHYQVTGDIGFLIDYGAEMLV
MAB_0578c|M.abscessus_ATCC_199 VLEHLPGPDRLHPLYTLAGTALPPEAVIDSLPGYAGSRPVRVGNAANSQV
. : :. .
MLBr_00414|M.leprae_Br4923 EHKRFGVAVHYRNVARDR-------------------------------V
MUL_0921|M.ulcerans_Agy99 EHKRFGVATHYRNAARNR-------------------------------V
MAV_4338|M.avium_104 EHKRFGVAVHYRNAARDR-------------------------------V
Rv2006|M.tuberculosis_H37Rv EIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNV
Mb2029|M.bovis_AF2122/97 EIARFWVGLAKLDDSRGRYLIRGVIGPDEFHSGYPGNEYDGIDNNAYTNV
MMAR_2257|M.marinum_M EIARFWVSRATYDAERDRYHIKGVIGPDEFHSGYPDRPYDGVDDNAYTNV
TH_1155|M.thermoresistible__bu EIARFWVSRAEFDTRRGRYRIRGVIGPDEFHAGYPDRPFDGVDDNAYTNV
Mvan_4107|M.vanbaalenii_PYR-1 EVARFFVSLASYDEDRERFGIKGVIGPDEFHSGYPEAPYDGIDNNAYTNV
MSMEG_3954|M.smegmatis_MC2_155 EIARFWAGLALFSRERGRYVIPGVIGPDEFHTGYPGRLYDGIDNNAYTNV
Mflv_4989|M.gilvum_PYR-GCK EITKFWVSAANLDPHRDRYVIRGVIGPDEFHSGYPGREYDGVDNNAYTNL
MAB_0578c|M.abscessus_ATCC_199 QLDVFGPVVELIHDLSHARKHLG---------------------------
: *
MLBr_00414|M.leprae_Br4923 NEVAVAVRTAGQRNALRVTTGREVIELR----------------------
MUL_0921|M.ulcerans_Agy99 GKIAAVVRAAGQRDGLRVTTGREVIELH----------------------
MAV_4338|M.avium_104 GEVAAAVRAAGRHDALRVTTGREVIELR----------------------
Rv2006|M.tuberculosis_H37Rv MAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFH
Mb2029|M.bovis_AF2122/97 MAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERDQWDDVSRRMFVPFH
MMAR_2257|M.marinum_M MAAWVILRAIDALLLMPLPNRLDLYEKLALTEEELAQWDHVSRRMFVPFH
TH_1155|M.thermoresistible__bu MAVWVILRALEALNLIPLPNRIDVREKLNLTAAELAQWDDVSRRMYVPFH
Mvan_4107|M.vanbaalenii_PYR-1 MAVWVIMRAIDALNLLPLPNRLDLLEALGLHNEELAHWDDVSRRMYVPFH
MSMEG_3954|M.smegmatis_MC2_155 MAVWVILRALDALDAMPLADRTALLERLGLHGDELDKWEDVSHRMFVPFH
Mflv_4989|M.gilvum_PYR-GCK MAVWVIVRTLEALERLPLSYRLALLETVGVGDEDLAHWEDVSRRMFVPFH
MAB_0578c|M.abscessus_ATCC_199 HSDPLTDADWNLVSDMVLAVERRWYEPDHG--------------------
: :. *
MLBr_00414|M.leprae_Br4923 -------------PDIDWDKGKTLHWVIDRLHHAGTQV-----------G
MUL_0921|M.ulcerans_Agy99 -------------PDIDWDKGKTLRWVIDHLPDQ---------------R
MAV_4338|M.avium_104 -------------PDLDWDKGKTLHWVIEHLRRS---------------G
Rv2006|M.tuberculosis_H37Rv DGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQ
Mb2029|M.bovis_AF2122/97 DGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQASKQ
MMAR_2257|M.marinum_M DGVISQFDGYEQLAELDWDAYRQRYGNIQRLDRILEAEDDDVNRYRASKQ
TH_1155|M.thermoresistible__bu DGIISQFEGYGELAELDWDGYRRRYGNIQRLDRILEAEGDDVNRYKASKQ
Mvan_4107|M.vanbaalenii_PYR-1 DGVISQFEGYGDLADLDWDRLRRQYGNIQRLDRILEAENDDVNRYKASKQ
MSMEG_3954|M.smegmatis_MC2_155 NGVISQFEGYESLVELDWDRYRHEYGNIQRLDRILEAENDNVNRYKASKQ
Mflv_4989|M.gilvum_PYR-GCK DGVITQFEGYDRLRELDWEAYRNRYDDLQRLDRILEAEGDSVNNYRAGKQ
MAB_0578c|M.abscessus_ATCC_199 ------------IWEIRGNPRHHVYSKVMCWVTVDR-------------A
:: : : :
MLBr_00414|M.leprae_Br4923 SASLMPICLG-----DDITDEDAFDAVRHTDVGGIPIVVRHTEDGNRATA
MUL_0921|M.ulcerans_Agy99 AAPLVPIYLG-----DDITDEDAFDAVGP---NGVAIMVRHNEDGDRATA
MAV_4338|M.avium_104 SGALTPVYLG-----DDITDEDAFDAVRGGPVQGVPILVRHNDDGDRATA
Rv2006|M.tuberculosis_H37Rv ADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSA
Mb2029|M.bovis_AF2122/97 ADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSA
MMAR_2257|M.marinum_M ADALMLLYLLSADELGELLDRLGYHMERDQIPEMVDYYMARTSHGSTLSA
TH_1155|M.thermoresistible__bu ADALMLLYLLSADELRELLGHLGYRFTAEQIPGMVDYYLARTSHGSTLSA
Mvan_4107|M.vanbaalenii_PYR-1 ADALMLLYLLSADELREILDRLGYRFLPEQVPKMVDYYLARTSHGSTLSG
MSMEG_3954|M.smegmatis_MC2_155 ADVLMLFYLLSADEIRELLARLGYRFTPKQIPETVDYYLSRTSHGSTLSA
Mflv_4989|M.gilvum_PYR-GCK ADTLMLFYLLSADELYELFDRLGYNFAPEQIPATIDYYQKRTSHGSTLSA
MAB_0578c|M.abscessus_ATCC_199 VKLAEEFERAAPSSWAALRDEIAAEVIEKGWNESVNSYTAAY-DGTDLDA
. : . . : .* .
MLBr_00414|M.leprae_Br4923 ALFTLDSP-----MHVSEFTERLARQLSDTQR------------------
MUL_0921|M.ulcerans_Agy99 ALFALESP-----ARVAEFTGRLASQLSTLG-------------------
MAV_4338|M.avium_104 ALFALDSP-----ARAAEFTERLADQLERGEG------------------
Rv2006|M.tuberculosis_H37Rv VVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDL
Mb2029|M.bovis_AF2122/97 VVHAWVLARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDL
MMAR_2257|M.marinum_M AVHGWVLARANRDRALEFFQQVLESDVADIQGGTTAEGVHLAAMAGSVDF
TH_1155|M.thermoresistible__bu VVHAWVLARANRDRAMEYFERVLKSDVADIQGGTTAEGIHLAAMAGSVDL
Mvan_4107|M.vanbaalenii_PYR-1 VVHTWVLARANRNRALEFFQQALKSDVSDIQGGTTSEGIHLAAMAGTVDL
MSMEG_3954|M.smegmatis_MC2_155 VVHSWVLARGHREQAMEFFVQALNSDVADIQGGTTAEGIHLAAMAGSVDL
Mflv_4989|M.gilvum_PYR-GCK VVHSWVLARGDRREAMHYFRRVLASDVVDIQRGTTAEGIHLAAMAGSIDL
MAB_0578c|M.abscessus_ATCC_199 ATLYIGLSGLIDPTDPRFTATVIATEAELRSGATVYRYHRDDCLPGGEGG
. . : :
MLBr_00414|M.leprae_Br4923 --------------------------------------------------
MUL_0921|M.ulcerans_Agy99 --------------------------------------------------
MAV_4338|M.avium_104 --------------------------------------------------
Rv2006|M.tuberculosis_H37Rv LQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRISGRSATL
Mb2029|M.bovis_AF2122/97 PQRCYSGLELRDDRLVLSPQWPEALGPLEFPFVYRRHQLSLRISGRSATL
MMAR_2257|M.marinum_M VQRCFTGLEIRADRIVLSPHWPEYLGALGFPIHYRGNHLHLRVSGKGAEI
TH_1155|M.thermoresistible__bu VQRCFTGLETRSDRIVLSPNWPESLGALGFPIRYRGHQMYVRVSGRGAEI
Mvan_4107|M.vanbaalenii_PYR-1 MQRCFTGLETRSNRIILSPYWPESLGVLAIPIHYRGLHLHLRVSGKGVII
MSMEG_3954|M.smegmatis_MC2_155 LQRCFTGLETRGDRLVLGPCWPEALGVLSFRMYYRGHNLHLRVSGRTASV
Mflv_4989|M.gilvum_PYR-GCK LQRCFTGLELRRDRIVVGPMWPEPLGRLAFTFRYRGHRLRLTVLGRSSTL
MAB_0578c|M.abscessus_ATCC_199 FHLCAAWLVEAYLLIGARSQAELLFDQLVKATGPTGLLSEEYDPVAERSL
MLBr_00414|M.leprae_Br4923 ---------------------------------
MUL_0921|M.ulcerans_Agy99 ---------------------------------
MAV_4338|M.avium_104 ---------------------------------
Rv2006|M.tuberculosis_H37Rv TAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR
Mb2029|M.bovis_AF2122/97 TAESGDAEPIEVECRGHVQRLRCGHTIEVGCSR
MMAR_2257|M.marinum_M SVEPRDVPPVEVECHGRVERLLPGSTVRFS---
TH_1155|M.thermoresistible__bu SVAPRDLPPVAVECNGRVQRLEPGTTVRFT---
Mvan_4107|M.vanbaalenii_PYR-1 SVDPRDAAGIEVECRGQVVQLMPGTTVRFPG--
MSMEG_3954|M.smegmatis_MC2_155 ISAIGSAAPITLECRGRTWQLCAGTTIDVG---
Mflv_4989|M.gilvum_PYR-GCK SAEPSEASPILVECRGQAQTLVAGGTVEFTR--
MAB_0578c|M.abscessus_ATCC_199 GNHPQAYSHIGLLRCAALLS-------------